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Your search keyword '"Henke, David M."' showing total 16 results
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16 results on '"Henke, David M."'

1. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

Author

Nair, Amritha, Chung, Hsiang-Ching, Sun, Tingting, Tyagi, Siddhartha, Dobrolecki, Lacey E, Dominguez-Vidana, Rocio, Kurley, Sarah J, Orellana, Mayra, Renwick, Alexander, Henke, David M, Katsonis, Panagiotis, Schmitt, Earlene, Chan, Doug W, Li, Hui, Mao, Sufeng, Petrovic, Ivana, Creighton, Chad J, Gutierrez, Carolina, Dubrulle, Julien, Stossi, Fabio, Tyner, Jeffrey W, Lichtarge, Olivier, Lin, Charles Y, Zhang, Bing, Scott, Kenneth L, Hilsenbeck, Susan G, Sun, Jinpeng, Yu, Xiao, Osborne, C Kent, Schiff, Rachel, Christensen, James G, Shields, David J, Rimawi, Mothaffar F, Ellis, Matthew J, Shaw, Chad A, Lewis, Michael T, and Westbrook, Thomas F

Subjects
Cell receptors -- Health aspects, Esterases -- Health aspects, Gene mutation -- Health aspects, Breast cancer -- Genetic aspects -- Development and progression -- Care and treatment, Gene expression -- Health aspects, Biological sciences, Health
Abstract

Author(s): Amritha Nair [1, 2]; Hsiang-Ching Chung [1, 2, 3]; Tingting Sun [1, 2]; Siddhartha Tyagi [1, 2]; Lacey E Dobrolecki [4]; Rocio Dominguez-Vidana [1, 2, 3]; Sarah J Kurley [...]

Published
2018
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4. Evidence for Feasibility of Fetal Trophoblastic Cell-Based Noninvasive Prenatal Testing

Author

Breman, Amy M., Chow, Jennifer C., U’Ren, Lance, Normand, Elizabeth A., Qdaisat, Sadeem, Zhao, Li, Henke, David M., Chen, Rui, Shaw, Chad A., Jackson, Laird, Yang, Yaping, Vossaert, Liesbeth, Needham, Rachel H. V., Chang, Elizabeth J., Campton, Daniel, Werbin, Jeffrey L., Seubert, Ron C., Van den Veyver, Ignatia B., Stilwell, Jackie L., Kaldjian, Eric P., and Beaudet, Arthur L.

Published
2017
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5. Proposal for Human Respiratory Syncytial Virus Nomenclature below the Species Level

Author

Salimi, Vahid, primary, Viegas, Mariana, additional, Trento, Alfonsina, additional, Agoti, Charles N., additional, Anderson, Larry J., additional, Avadhanula, Vasanthi, additional, Bahl, Justin, additional, Bont, Louis, additional, Brister, J. Rodney, additional, Cane, Patricia A., additional, Galiano, Mónica, additional, Graham, Barney S., additional, Hatcher, Eneida L., additional, Hellferscee, Orienka, additional, Henke, David M., additional, Hirve, Siddhivinayak, additional, Jackson, Sandra, additional, Keyaerts, Els, additional, Kragten-Tabatabaie, Leyla, additional, Lindstrom, Stephen, additional, Nauwelaers, Inne, additional, Nokes, D. James, additional, Openshaw, Peter J., additional, Peret, Teresa C., additional, Piedra, Pedro A., additional, Ramaekers, Kaat, additional, Rector, Annabel, additional, Trovão, Nídia Sequeira, additional, von Gottberg, Anne, additional, Zambon, Maria, additional, Zhang, Wenqing, additional, Williams, Thomas C., additional, Barr, Ian G., additional, and Buchholz, Ursula J., additional

Published
2021
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6. Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients

Author

Ye, Xunyan, primary, Iwuchukwu, Obinna P., additional, Avadhanula, Vasanthi, additional, Aideyan, Letisha O., additional, McBride, Trevor J., additional, Henke, David M., additional, Patel, Kirtida D., additional, Piedra, Felipe-Andres, additional, Angelo, Laura S., additional, Shah, Dimpy P., additional, Chemaly, Roy F., additional, and Piedra, Pedro A., additional

Published
2021
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7. Proposal for Human Respiratory Syncytial Virus Nomenclature below the Species Level

Author

CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Salimi, Vahid, Viegas, Mariana, Trento, Alfonsina, Agoti, Charles N, Anderson, Larry J, Avadhanula, Vasanthi, Bahl, Justin, Bont, Louis, Brister, J Rodney, Cane, Patricia A, Galiano, Mónica, Graham, Barney S, Hatcher, Eneida L, Hellferscee, Orienka, Henke, David M, Hirve, Siddhivinayak, Jackson, Sandra, Keyaerts, Els, Kragten-Tabatabaie, Leyla, Lindstrom, Stephen, Nauwelaers, Inne, Nokes, D James, Openshaw, Peter J, Peret, Teresa C, Piedra, Pedro A, Ramaekers, Kaat, Rector, Annabel, Trovão, Nídia Sequeira, von Gottberg, Anne, Zambon, Maria, Zhang, Wenqing, Williams, Thomas C, Barr, Ian G, Buchholz, Ursula J, CTI Bont, Infectieziekten onderzoek1 (Bont), Child Health, Infection & Immunity, Salimi, Vahid, Viegas, Mariana, Trento, Alfonsina, Agoti, Charles N, Anderson, Larry J, Avadhanula, Vasanthi, Bahl, Justin, Bont, Louis, Brister, J Rodney, Cane, Patricia A, Galiano, Mónica, Graham, Barney S, Hatcher, Eneida L, Hellferscee, Orienka, Henke, David M, Hirve, Siddhivinayak, Jackson, Sandra, Keyaerts, Els, Kragten-Tabatabaie, Leyla, Lindstrom, Stephen, Nauwelaers, Inne, Nokes, D James, Openshaw, Peter J, Peret, Teresa C, Piedra, Pedro A, Ramaekers, Kaat, Rector, Annabel, Trovão, Nídia Sequeira, von Gottberg, Anne, Zambon, Maria, Zhang, Wenqing, Williams, Thomas C, Barr, Ian G, and Buchholz, Ursula J

Published
2021

9. Design tools for MPRA experiments

Author

Ghazi, Andrew R, primary, Chen, Edward S, additional, Henke, David M, additional, Madan, Namrata, additional, Edelstein, Leonard C, additional, and Shaw, Chad A, additional

Published
2018
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10. The association between anterior nares and nasopharyngeal microbiota in infants hospitalized for bronchiolitis

Author

Luna, Pamela N., primary, Hasegawa, Kohei, additional, Ajami, Nadim J., additional, Espinola, Janice A., additional, Henke, David M., additional, Petrosino, Joseph F., additional, Piedra, Pedro A., additional, Sullivan, Ashley F., additional, Camargo, Carlos A., additional, Shaw, Chad A., additional, and Mansbach, Jonathan M., additional

Published
2018
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14. Evidence for feasibility of fetal trophoblastic cell‐based noninvasive prenatal testing

Author

Breman, Amy M., primary, Chow, Jennifer C., additional, U'Ren, Lance, additional, Normand, Elizabeth A., additional, Qdaisat, Sadeem, additional, Zhao, Li, additional, Henke, David M., additional, Chen, Rui, additional, Shaw, Chad A., additional, Jackson, Laird, additional, Yang, Yaping, additional, Vossaert, Liesbeth, additional, Needham, Rachel H. V., additional, Chang, Elizabeth J., additional, Campton, Daniel, additional, Werbin, Jeffrey L., additional, Seubert, Ron C., additional, Van den Veyver, Ignatia B., additional, Stilwell, Jackie L., additional, Kaldjian, Eric P., additional, and Beaudet, Arthur L., additional

Published
2016
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16. The association between anterior nares and nasopharyngeal microbiota in infants hospitalized for bronchiolitis

Author

Luna, Pamela N., Hasegawa, Kohei, Ajami, Nadim J., Espinola, Janice A., Henke, David M., Petrosino, Joseph F., Piedra, Pedro A., Sullivan, Ashley F., Camargo, Carlos A., Shaw, Chad A., and Mansbach, Jonathan M.

Subjects
Microbiota, Bronchiolitis, Asthma, Nasopharynx, Anterior nares
Abstract

Background: The airway microbiome is a subject of great interest for the study of respiratory disease. Anterior nare samples are more accessible than samples from deeper within the nasopharynx. However, the correlation between the microbiota found in the anterior nares and the microbiota found within the nasopharynx is unknown. We assessed the anterior nares and nasopharyngeal microbiota to determine (1) the relation of the microbiota from these two upper airway sites and (2) if associations were maintained between the microbiota from these two sites and two bronchiolitis severity outcomes. Results: Among 815 infants hospitalized at 17 US centers for bronchiolitis with optimal 16S rRNA gene sequence reads from both nasal swab and nasopharyngeal aspirate samples, there were strong intra-individual correlations in the microbial communities between the two sample types, especially relating to Haemophilus and Moraxella genera. By contrast, we found a high abundance of Staphylococcus genus in the nasal swabs—a pattern not found in the nasopharyngeal samples and not informative when predicting the dominant nasopharyngeal genera. While these disparities may have been due to sample processing differences (i.e., nasal swabs were mailed at ambient temperature to emulate processing of future parent collected swabs while nasopharyngeal aspirates were mailed on dry ice), a previously reported association between Haemophilus-dominant nasopharyngeal microbiota and the increased severity of bronchiolitis was replicated utilizing the nasal swab microbiota and the same outcome measures: intensive care use (adjusted OR 6.43; 95% CI 2.25–20.51; P < 0.001) and hospital length-of-stay (adjusted OR 4.31; 95% CI, 1.73–11.11; P = 0.002). Additionally, Moraxella-dominant nasopharyngeal microbiota was previously identified as protective against intensive care use, a result that was replicated when analyzing the nasal swab microbiota (adjusted OR 0.30; 95% CI, 0.11–0.64; P = 0.01). Conclusions: While the microbiota of the anterior nares and the nasopharynx are distinct, there is considerable overlap between the bacterial community compositions from these two anatomic sites. Despite processing differences between the samples, these results indicate that microbiota severity associations from the nasopharynx are recapitulated in the anterior nares, suggesting that nasal swab samples not only are effective sample types, but also can be used to detect microbial risk markers. Electronic supplementary material The online version of this article (10.1186/s40168-017-0385-0) contains supplementary material, which is available to authorized users.

Published
2018
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