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21 results on '"Hennies, Steffen"'

11. MRI versus 68Ga-PSMA PET/CT for gross tumour volume delineation in radiation treatment planning of primary prostate cancer

Author

Zamboglou, Constantinos, primary, Wieser, Gesche, additional, Hennies, Steffen, additional, Rempel, Irene, additional, Kirste, Simon, additional, Soschynski, Martin, additional, Rischke, Hans Christian, additional, Fechter, Tobias, additional, Jilg, Cordula A., additional, Langer, Mathias, additional, Meyer, Philipp T., additional, Bock, Michael, additional, and Grosu, Anca-Ligia, additional

Published
2015
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12. Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy

Author

Dröge, Leif Hendrik, primary, Weber, Hanne Elisabeth, additional, Guhlich, Manuel, additional, Leu, Martin, additional, Conradi, Lena-Christin, additional, Gaedcke, Jochen, additional, Hennies, Steffen, additional, Herrmann, Markus Karl, additional, Rave-Fränk, Margret, additional, and Wolff, Hendrik Andreas, additional

Published
2015
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13. MRI versus Ga-PSMA PET/CT for gross tumour volume delineation in radiation treatment planning of primary prostate cancer.

Author

Zamboglou, Constantinos, Wieser, Gesche, Hennies, Steffen, Rempel, Irene, Kirste, Simon, Soschynski, Martin, Rischke, Hans, Fechter, Tobias, Jilg, Cordula, Langer, Mathias, Meyer, Philipp, Bock, Michael, and Grosu, Anca-Ligia

Subjects
PROSTATE-specific membrane antigen, PROSTATE cancer, MAGNETIC resonance imaging, RADIOTHERAPY, DIAGNOSIS
Abstract

Purpose: Multiparametric magnetic resonance imaging (mpMRI) is widely used in radiation treatment planning of primary prostate cancer (PCA). Focal dose escalation to the dominant intraprostatic lesions (DIPL) may lead to improved PCA control. Prostate-specific membrane antigen (PSMA) is overexpressed in most PCAs. Ga-labelled PSMA inhibitors have demonstrated promising results in detection of PCA with PET/CT. The aim of this study was to compare Ga-PSMA PET/CT with MRI for gross tumour volume (GTV) definition in primary PCA. Methods: This retrospective study included 22 patients with primary PCA analysed after Ga-PSMA PET/CT and mpMRI. GTVs were delineated on MR images by two radiologists (GTV-MRIrad) and two radiation oncologists separately. Both volumes were merged leading to GTV-MRIint. GTVs based on PET/CT were delineated by two nuclear medicine physicians in consensus (GTV-PET). Laterality (left, right, and left and right prostate lobes) on mpMRI, PET/CT and pathological analysis after biopsy were assessed. Results: Mean GTV-MRIrad, GTV-MRIint and GTV-PET were 5.92, 3.83 and 11.41 cm, respectively. GTV-PET was significant larger then GTV-MRIint ( p = 0.003). The MRI GTVs GTV-MRIrad and GTV-MRIint showed, respectively, 40 % and 57 % overlap with GTV-PET. GTV-MRIrad and GTV-MRIint included the SUVmax of GTV-PET in 12 and 11 patients (54.6 % and 50 %), respectively. In nine patients (47 %), laterality on mpMRI, PET/CT and histopathology after biopsy was similar. Conclusion: Ga-PSMA PET/CT and mpMRI provided concordant results for delineation of the DIPL in 47 % of patients (40 % - 54 % of lesions). GTV-PET was significantly larger than GTV-MRIint. Ga-PSMA PET/CT may have a role in radiation treatment planning for focal radiation to the DIPL. Exact correlation of PET and MRI images with histopathology is needed. [ABSTRACT FROM AUTHOR]

Published
2016
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17. Comparison of the Micronucleus and Chromosome Aberration Techniques for the Documentationof Cytogenetic Damage in Radiochemotherapy-Treated Patients with Rectal Cancer

Author

Wolff*, Hendrik Andreas, primary, Hennies, Steffen, additional, Herrmann, Markus Karl Alfred, additional, Rave-Fränk, Margret, additional, Eickelmann, David, additional, Virsik, Patricia, additional, Jung, Klaus, additional, Schirmer, Markus, additional, Ghadimi, Michael, additional, Hess, Clemens Friedrich, additional, Hermann, Robert Michael, additional, and Christiansen, Hans, additional

Published
2010
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18. High-Grade Acute Organ Toxicity During Preoperative Radiochemotherapy as Positive Predictor for Complete Histopathologic Tumor Regression in Multimodal Treatment of Locally Advanced Rectal Cancer*

Author

Wolff, Hendrik Andreas, primary, Gaedcke, Jochen, additional, Jung, Klaus, additional, Hermann, Robert Michael, additional, Rothe, Hilka, additional, Schirmer, Markus, additional, Liersch, Torsten, additional, Herrmann, Markus Karl Alfred, additional, Hennies, Steffen, additional, Rave-Fränk, Margret, additional, Hess, Clemens Friedrich, additional, and Christiansen, Hans, additional

Published
2009
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19. Nasopharyngeal carcinoma in adults: treatment results after long-term follow-up with special reference to adjuvant interferon-beta in undifferentiated carcinomas

Author

Wolff, Hendrik Andreas, primary, Rödel, Ralph M. W., additional, Gunawan, Bastian, additional, Overbeck, Tobias, additional, Herrmann, Markus K. A., additional, Hennies, Steffen, additional, Hille, Andrea, additional, Vorwerk, Hilke, additional, Matthias, Christoph, additional, Hess, Clemens F., additional, and Christiansen, Hans, additional

Published
2009
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20. Comparison of the micronucleus and chromosome aberration techniques for the documentation of cytogenetic damage in radiochemotherapy-treated patients with rectal cancer.

Author

Wolff*, Hendrik, Hennies, Steffen, Herrmann, Markus, Rave-Fränk, Margret, Eickelmann, David, Virsik, Patricia, Jung, Klaus, Schirmer, Markus, Ghadimi, Michael, Hess, Clemens, Hermann, Robert, Christiansen, Hans, Wolff, Hendrik Andreas, Herrmann, Markus Karl Alfred, Rave-Fränk, Margret, Hess, Clemens Friedrich, and Hermann, Robert Michael

Abstract

Copyright of Strahlentherapie und Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011
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21. Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy

Author

Dröge, Leif Hendrik, Weber, Hanne Elisabeth, Guhlich, Manuel, Leu, Martin, Conradi, Lena-Christin, Gaedcke, Jochen, Hennies, Steffen, Herrmann, Markus Karl, Rave-Fränk, Margret, and Wolff, Hendrik Andreas

Subjects
Adult, Male, 3D conformal radiotherapy, Cancer Research, Kaplan-Meier Estimate, Preoperative Care, Genetics, Humans, Rectal cancer, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Acute toxicity, Rectal Neoplasms, Volumetric modulated arc therapy, Chemoradiotherapy, Middle Aged, Combined Modality Therapy, Tumor regression grading, Treatment Outcome, Oncology, Female, Radiotherapy, Intensity-Modulated, Radiotherapy, Conformal, Late toxicity, Research Article
Abstract

Background Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). In a single-center retrospective analysis, we tested whether these advantages may translate into significant clinical benefits. We compared VMAT to conventional 3D conformal radiotherapy (3DCRT) in patients, homogeneously treated according to the control arm of the CAO/ARO/AIO-04 trial. Methods CRT consisted of pelvic irradiation with 50.4/1.8Gy by VMAT (n = 81) or 3DCRT (n = 107) and two cycles of 5-fluorouracil. Standardized total mesorectal excision surgery was performed within 4–6 weeks. The tumor regression grading (TRG) was assessed by the Dworak score. Acute and late toxicity were evaluated via the Common Terminology Criteria for Adverse Events and the Late effects of normal tissues scale, respectively. Side effects greater than or equal to grade 3 were considered high-grade. Results Median follow-up was 18.3 months in the VMAT group and 61.5 months in the 3DCRT group with no differences in TRG between them (p = 0.1727). VMAT treatment substantially reduced high-grade acute and late toxicity, with 5 % versus 20 % (p = 0.0081) and 6 % vs. 22 % (p = 0.0039), respectively. With regard to specific organs, differences were found in skin reaction (p = 0.019) and proctitis (p = 0.0153). Conclusions VMAT treatment in preoperative CRT for LARC showed the potential to substantially reduce high-grade acute and late toxicity. Importantly, we could demonstrate that VMAT irradiation did not impair short-term oncological results. We conclude, that the reduced toxicity after VMAT irradiation may pave the way for more efficient systemic therapies, and hopefully improved patient survival in the multimodal treatment of LARC. Electronic supplementary material The online version of this article (doi:10.1186/s12885-015-1812-x) contains supplementary material, which is available to authorized users.

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