426 results on '"Hennig D"'
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2. Existence, stability and spatio-temporal dynamics of time-quasiperiodic solutions on a finite background in discrete nonlinear Schrödinger models
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Charalampidis, E.G., James, G., Cuevas-Maraver, J., Hennig, D., Karachalios, N.I., and Kevrekidis, P.G.
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- 2024
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3. Verification of the code DYN3D for calculations of neutron flux fluctuations
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Viebach, M., Lange, C., Kliem, S., Demazière, C., Rohde, U., Hennig, D., and Hurtado, A.
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- 2022
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4. Cooperative surmounting of bottlenecks
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Hennig, D., Mulhern, C., Schimansky-Geier, L., Tsironis, G. P., and Hänggi, P.
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Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
The physics of activated escape of objects out of a metastable state plays a key role in diverse scientific areas involving chemical kinetics, diffusion and dislocation motion in solids, nucleation, electrical transport, motion of flux lines superconductors, charge density waves, and transport processes of macromolecules, to name but a few. The underlying activated processes present the multidimensional extension of the Kramers problem of a single Brownian particle. In comparison to the latter case, however, the dynamics ensuing from the interactions of many coupled units can lead to intriguing novel phenomena that are not present when only a single degree of freedom is involved. In this review we report on a variety of such phenomena that are exhibited by systems consisting of chains of interacting units in the presence of potential barriers. In the first part we consider recent developments in the case of a deterministic dynamics driving cooperative escape processes of coupled nonlinear units out of metastable states. The ability of chains of coupled units to undergo spontaneous conformational transitions can lead to a self-organised escape. The mechanism at work is that the energies of the units become re-arranged, while keeping the total energy conserved, in forming localised energy modes that in turn trigger the cooperative escape. We present scenarios of significantly enhanced noise-free escape rates if compared to the noise-assisted case. The second part deals with the collective directed transport of systems of interacting particles overcoming energetic barriers in periodic potential landscapes. Escape processes in both time-homogeneous and time-dependent driven systems are considered for the emergence of directed motion. It is shown that ballistic channels immersed in the associated high-dimensional phase space are the source for the directed long-range transport.
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- 2015
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5. Nonlinear response of a linear chain to weak driving
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Hennig, D., Mulhern, C., Burbanks, A. D., and Schimansky-Geier, L.
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Nonlinear Sciences - Pattern Formation and Solitons - Abstract
We study the escape of a chain of coupled units over the barrier of a metastable potential. It is demonstrated that a very weak external driving field with suitably chosen frequency suffices to accomplish speedy escape. The latter requires the passage through a transition state the formation of which is triggered by permanent feeding of energy from a phonon background into humps of localised energy and elastic interaction of the arising breather solutions. In fact, cooperativity between the units of the chain entailing coordinated energy transfer is shown to be crucial for enhancing the rate of escape in an extremely effective and low-energy cost way where the effect of entropic localisation and breather coalescence conspire.
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- 2013
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6. From collective periodic running states to completely chaotic synchronised states in coupled particle dynamics
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Hennig, D., Burbanks, A. D., Osbaldestin, A. H., and Mulhern, C.
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Condensed Matter - Statistical Mechanics - Abstract
We consider the damped and driven dynamics of two interacting particles evolving in a symmetric and spatially periodic potential. The latter is exerted to a time-periodic modulation of its inclination. Our interest is twofold: Firstly we deal with the issue of chaotic motion in the higher-dimensional phase space. To this end a homoclinic Melnikov analysis is utilised assuring the presence of transverse homoclinic orbits and homoclinic bifurcations for weak coupling allowing also for the emergence of hyperchaos. In contrast, we also prove that the time evolution of the two coupled particles attains a completely synchronised (chaotic) state for strong enough coupling between them. The resulting `freezing of dimensionality' rules out the occurrence of hyperchaos. Secondly we address coherent collective particle transport provided by regular periodic motion. A subharmonic Melnikov analysis is utilised to investigate persistence of periodic orbits. For directed particle transport mediated by rotating periodic motion we present exact results regarding the collective character of the running solutions entailing the emergence of a current. We show that coordinated energy exchange between the particles takes place in such a manner that they are enabled to overcome - one particle followed by the other - consecutive barriers of the periodic potential resulting in collective directed motion.
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- 2011
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7. Directed current in the Holstein system
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Hennig, D., Burbanks, A. D., and Osbaldestin, A. H.
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Condensed Matter - Other Condensed Matter ,Quantum Physics - Abstract
We propose a mechanism to rectify charge transport in the semiclassical Holstein model. It is shown that localised initial conditions, associated with a polaron solution, in conjunction with a nonreversion symmetric static electron on-site potential constitute minimal prerequisites for the emergence of a directed current in the underlying periodic lattice system. In particular, we demonstrate that for unbiased spatially localised initial conditions, violation of parity prevents the existence of pairs of counter-propagating trajectories, thus allowing for a directed current despite the time-reversibility of the equations of motion. Occurrence of long-range coherent charge transport is demonstrated.
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- 2010
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8. Emergence of continual directed flow in Hamiltonian systems
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Hennig, D., Burbanks, A. D., Mulhern, C., and Osbaldestin, A. H.
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Condensed Matter - Statistical Mechanics - Abstract
We propose a minimal model for the emergence of a directed flow in autonomous Hamiltonian systems. It is shown that internal breaking of the spatio-temporal symmetries, via localised initial conditions, that are unbiased with respect to the transporting degree of freedom, and transient chaos conspire to form the physical mechanism for the occurrence of a current. Most importantly, after passage through the transient chaos, trajectories perform solely regular transporting motion so that the resulting current is of continual ballistic nature. This has to be distinguished from the features of transport reported previously for driven Hamiltonian systems with mixed phase space where transport is determined by intermittent behaviour exhibiting power-law decay statistics of the duration of regular ballistic periods.
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- 2010
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9. Directed transport of two interacting particles in a washboard potential
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Hennig, D., Burbanks, A. D., and Osbaldestin, A. H.
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Condensed Matter - Statistical Mechanics - Abstract
We study the conservative and deterministic dynamics of two nonlinearly interacting particles evolving in a one-dimensional spatially periodic washboard potential. A weak tilt of the washboard potential is applied biasing one direction for particle transport. However, the tilt vanishes asymptotically in the direction of bias. Moreover, the total energy content is not enough for both particles to be able to escape simultaneously from an initial potential well; to achieve transport the coupled particles need to interact cooperatively. For low coupling strength the two particles remain trapped inside the starting potential well permanently. For increased coupling strength there exists a regime in which one of the particles transfers the majority of its energy to the other one, as a consequence of which the latter escapes from the potential well and the bond between them breaks. Finally, for suitably large couplings, coordinated energy exchange between the particles allows them to achieve escapes -- one particle followed by the other -- from consecutive potential wells resulting in directed collective motion. The key mechanism of transport rectification is based on the asymptotically vanishing tilt causing a symmetry breaking of the non-chaotic fraction of the dynamics in the mixed phase space. That is, after a chaotic transient, only at one of the boundaries of the chaotic layer do resonance islands appear. The settling of trajectories in the ballistic channels associated with transporting islands provides long-range directed transport dynamics of the escaping dimer.
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- 2009
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10. Delayed feedback induced directed inertia particle transport in a washboard potential
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Hennig, D., Schimansky-Geier, L., and Hänggi, P.
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Condensed Matter - Statistical Mechanics - Abstract
We consider motion of an underdamped Brownian particle in a washboard potential that is subjected to an unbiased time-periodic external field. While in the limiting deterministic system in dependence of the strength and phase of the external field directed net motion can exist, for a finite temperature the net motion averages to zero. Strikingly, with the application of an additional time-delayed feedback term directed particle motion can be accomplished persisting up to fairly high levels of the thermal noise. In detail, there exist values of the feedback strength and delay time for which the feedback term performs oscillations that are phase locked to the time-periodic external field. This yields an effective biasing rocking force promoting periods of forward and backward motion of distinct duration, and thus directed motion. In terms of phase space dynamics we demonstrate that with applied feedback desymmetrization of coexisting attractors takes place leaving the ones supporting either positive or negative velocities as the only surviving ones. Moreover, we found parameter ranges for which in the presence of thermal noise the directed transport is enhanced compared to the noise-less case.
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- 2009
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11. Resonance-like phenomena of the mobility of a chain of nonlinear coupled oscillators in a two-dimensional periodic potential
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Martens, S., Hennig, D., Fugmann, S., and Schimansky-Geier, L.
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Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
We study the Langevin dynamics of a two-dimensional discrete oscillator chain absorbed on a periodic substrate and subjected to an external localized point force. Going beyond the commonly used harmonic bead-spring model, we consider a nonlinear Morse interaction between the next-nearest-neighbors. We focus interest on the activation of directed motion instigated by thermal fluctuations and the localized point force. In this context the local transition states are identified and the corresponding activation energies are calculated. As a novel feature it is found that the transport of the chain in point force direction is determined by stepwise escapes of a single unit or segments of the chain due to the existence of multiple locally stable attractors. The non-vanishing net current of the chain is quantitatively assessed by the value of the mobility of the center of mass. It turns out that the latter as a function of the ratio of the competing length scales of the system, that is the period of the substrate potential and the equilibrium distance between two chain units, shows a resonance behavior. More precisely there exist a set of optimal parameter values maximizing the mobility. Interestingly, the phenomenon of negative resistance is found, i.e. the mobility possesses a minimum at a finite value of the strength of the thermal fluctuations for a given overcritical external driving force., Comment: 25 pages, 12 figures
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- 2008
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12. Surmounting collectively oscillating bottlenecks
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Hennig, D., Schimansky-Geier, L., and Hänggi, P.
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Condensed Matter - Statistical Mechanics ,Nonlinear Sciences - Chaotic Dynamics ,Nonlinear Sciences - Pattern Formation and Solitons - Abstract
We study the collective escape dynamics of a chain of coupled, weakly damped nonlinear oscillators from a metastable state over a barrier when driven by a thermal heat bath in combination with a weak, globally acting periodic perturbation. Optimal parameter choices are identified that lead to a drastic enhancement of escape rates as compared to a pure noise-assisted situation. We elucidate the speed-up of escape in the driven Langevin dynamics by showing that the time-periodic external field in combination with the thermal fluctuations triggers an instability mechanism of the stationary homogeneous lattice state of the system. Perturbations of the latter provided by incoherent thermal fluctuations grow because of a parametric resonance, leading to the formation of spatially localized modes (LMs). Remarkably, the LMs persist in spite of continuously impacting thermal noise. The average escape time assumes a distinct minimum by either tuning the coupling strength and/or the driving frequency. This weak ac-driven assisted escape in turn implies a giant speed of the activation rate of such thermally driven coupled nonlinear oscillator chains.
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- 2008
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13. Slowly rocking symmetric, spatially periodic Hamiltonians: The role of escape and the emergence of giant transient directed transport
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Hennig, D., Schimansky-Geier, L., and Hänggi, P.
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Nonlinear Sciences - Chaotic Dynamics - Abstract
The nonintegrable Hamiltonian dynamics of particles placed in a symmetric, spatially periodic potential and subjected to a periodically varying field is explored. Such systems can exhibit a rich diversity of unusual transport features. In particular, depending on the setting of the initial phase of the drive, the possibility of a giant transient directed transport in a symmetric, space-periodic potential when driven with an adiabatically varying field arises. Here, we study the escape scenario and corresponding mean escape times of particles from a trapping region with the subsequent generation of a transient directed flow of an ensemble of particles. It is shown that for adiabatically slow inclination modulations the unidirectional flow proceeds over giant distances. The direction of escape and, hence, of the flow is entirely governed whether the periodic force, modulating the inclination of the potential, starts out initially positive or negative. In the phase space, this transient directed flow is associated with a long-lasting motion taking place within ballistic channels contained in the non-uniform chaotic layer. We demonstrate that for adiabatic modulations all escaping particles move ballistically into the same direction, leading to a giant directed current.
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- 2008
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14. Self-organized escape of oscillator chains in nonlinear potentials
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Hennig, D., Fugmann, S., Schimansky-Geier, L., and Hänggi, P.
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Condensed Matter - Statistical Mechanics - Abstract
We present the noise free escape of a chain of linearly interacting units from a metastable state over a cubic on-site potential barrier. The underlying dynamics is conservative and purely deterministic. The mutual interplay between nonlinearity and harmonic interactions causes an initially uniform lattice state to become unstable, leading to an energy redistribution with strong localization. As a result a spontaneously emerging localized mode grows into a critical nucleus. By surpassing this transition state, the nonlinear chain manages a self-organized, deterministic barrier crossing. Most strikingly, these noise-free, collective nonlinear escape events proceed generally by far faster than transitions assisted by thermal noise when the ratio between the average energy supplied per unit in the chain and the potential barrier energy assumes small values.
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- 2007
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15. Quantum Diffusion in Polaron Model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers
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Yamada, H., Starikov, E. B., and Hennig, D.
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Condensed Matter - Soft Condensed Matter - Abstract
We numerically investigate quantum diffusion of an electron in a model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers with fluctuation of the parameters due to the impact of colored noise. The randomness is introduced by fluctuations of distance between two consecutive bases along the stacked base pairs. We demonstrate that in the model the decay time of the correlation can control the spread of the electronic wavepacket. Furthermore it is shown that in a motional narrowing regime the averaging over fluctuation causes ballistic propagation of the wavepacket, and in the adiabatic regime the electronic states are affected by localization., Comment: 17pages, 8figures
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- 2007
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16. Modeling the thermal evolution of enzyme-created bubbles in DNA
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Hennig, D., Archilla, J. F. R., and Romero, J. M.
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Quantitative Biology - Biomolecules ,Nonlinear Sciences - Pattern Formation and Solitons - Abstract
The formation of bubbles in nucleic acids (NAs) are fundamental in many biological processes such as DNA replication, recombination, telomeres formation, nucleotide excision repair, as well as RNA transcription and splicing. These precesses are carried out by assembled complexes with enzymes that separate selected regions of NAs. Within the frame of a nonlinear dynamics approach we model the structure of the DNA duplex by a nonlinear network of coupled oscillators. We show that in fact from certain local structural distortions there originate oscillating localized patterns, that is radial and torsional breathers, which are associated with localized H-bond deformations, being reminiscent of the replication bubble. We further study the temperature dependence of these oscillating bubbles. To this aim the underlying nonlinear oscillator network of the DNA duplex is brought in contact with a heat bath using the Nos$\rm{\acute{e}}$-Hoover-method. Special attention is paid to the stability of the oscillating bubbles under the imposed thermal perturbations. It is demonstrated that the radial and torsional breathers, sustain the impact of thermal perturbations even at temperatures as high as room temperature. Generally, for nonzero temperature the H-bond breathers move coherently along the double chain whereas at T=0 standing radial and torsional breathers result., Comment: 19 pages, 7 figures
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- 2004
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17. Moving breathers in bent DNA with realistic parameters
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Cuevas, J., Starikov, E. B., Archilla, J. F. R., and Hennig, D.
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Nonlinear Sciences - Pattern Formation and Solitons ,Quantitative Biology - Biomolecules - Abstract
Recent papers have considered moving breathers (MBs) in DNA models including long range interaction due to the dipole moments of the hydrogen bonds. We have recalculated the value of the charge transfer when hydrogen bonds stretch using quantum chemical methods which takes into account the whole nucleoside pairs. We explore the consequences of this value on the properties of MBs, including the range of frequencies for which they exist and their effective masses. They are able to travel through bending points with fairly large curvatures provided that their kinetic energy is larger than a minimum energy which depends on the curvature. These energies and the corresponding velocities are also calculated in function of the curvature., Comment: 4 pages and 4 figures
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- 2004
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18. Thermal stability of charge transport in poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers
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Hennig, D., Archilla, J. F. R., Dorignac, J., and Starikov, E. B.
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Nonlinear Sciences - Pattern Formation and Solitons - Abstract
This paper has been withdrawn due to some inconsistency of the results discovered after the submission. We apologize for it., Comment: This paper has been withdrawn
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- 2003
19. Charge transport in poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers
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Hennig, D., Starikov, E. B., Archilla, J. F. R., and Palmero, F.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter - Soft Condensed Matter ,Nonlinear Sciences - Adaptation and Self-Organizing Systems ,Quantitative Biology - Biomolecules - Abstract
We investigate the charge transport in synthetic DNA polymers built up from single types of base pairs. In the context of a polaron-like model, for which an electronic tight-binding system and bond vibrations of the double helix are coupled, we present estimates for the electron-vibration coupling strengths utilizing a quantum-chemical procedure. Subsequent studies concerning the mobility of polaron solutions, representing the state of a localized charge in unison with its associated helix deformation, show that the system for poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers, respectively possess quantitatively distinct transport properties. While the former supports unidirectionally moving electron breathers attributed to highly efficient long-range conductivity the breather mobility in the latter case is comparatively restrained inhibiting charge transport. Our results are in agreement with recent experimental results demonstrating that poly(dG)-poly(dC) DNA molecules acts as a semiconducting nanowire and exhibits better conductance than poly(dA)-poly(dT) ones., Comment: 11 pages, 5 figures
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- 2003
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20. Effect of base-pair inhomogeneities on charge transport along DNA mediated by twist and radial polarons
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Palmero, F., Archilla, J. F. R., Hennig, D., and Romero, F. R.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter - Soft Condensed Matter ,Quantitative Biology - Biomolecules - Abstract
Some recent results for a three--dimensional, semi--classical, tight--binding model for DNA show that there are two types of polarons, named radial and twist polarons, that can transport charge along the DNA molecule. However, the existence of two types of base pairs in real DNA, makes it crucial to find out if charge transport also exist in DNA chains with different base pairs. In this paper we address this problem in its simple case, an homogeneous chain except for a single different base pair, what we call a base-pair inhomogeneity, and its effect on charge transport. Radial polarons experience either reflection or trapping. However, twist polarons are good candidates for charge transport along real DNA. This transport is also very robust with respect to weak parametric and diagonal disorder., Comment: 21 pages, 10 figures
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- 2003
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21. Stretching and relaxation dynamics in double stranded DNA
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Hennig, D. and Archilla, J. F. R.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter - Soft Condensed Matter ,Quantitative Biology - Biomolecules - Abstract
We study numerically the mechanical stability and elasticity properties of duplex DNA molecules within the frame of a network model incorporating microscopic degrees of freedom related with the arrangement of the base pairs. We pay special attention to the opening-closing dynamics of double-stranded DNA molecules which are forced into non-equilibrium conformations. Mechanical stress imposed at one terminal end of the DNA molecule brings it into a partially opened configuration. We examine the subsequent relaxation dynamics connected with energy exchange processes between the various degrees of freedom and structural rearrangements leading to complete recombination to the double-stranded conformation. The similarities and differences between the relaxation dynamics for a planar ladder-like DNA molecule and a twisted one are discussed in detail. In this way we show that the attainment of a quasi-equilibrium regime proceeds faster in the case of the twisted DNA form than for its thus less flexible ladder counterpart. Furthermore we find that the velocity of the complete recombination of the DNA molecule is lower than the velocity imposed by the forcing unit which is in compliance with the experimental observations for the opening-closing cycle of DNA molecules., Comment: 21 pages, 9 figures
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- 2003
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22. Multi-site H-bridge breathers in a DNA--shaped double strand
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Hennig, D. and Archilla, J. F. R.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter ,Nonlinear Sciences - Adaptation and Self-Organizing Systems ,Quantitative Biology - Biomolecules - Abstract
We investigate the formation process of nonlinear vibrational modes representing broad H-bridge multi--site breathers in a DNA--shaped double strand. Within a network model of the double helix we take individual motions of the bases within the base pair plane into account. The resulting H-bridge deformations may be asymmetric with respect to the helix axis. Furthermore the covalent bonds may be deformed distinctly in the two backbone strands. Unlike other authors that add different extra terms we limit the interaction to the hydrogen bonds within each base pair and the covalent bonds along each strand. In this way we intend to make apparent the effect of the characteristic helicoidal structure of DNA. We study the energy exchange processes related with the relaxation dynamics from a non-equilibrium conformation. It is demonstrated that the twist-opening relaxation dynamics of a radially distorted double helix attains an equilibrium regime characterized by a multi-site H-bridge breather., Comment: 27 pages and 10 figures
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- 2003
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23. Nonlinear charge transport mechanism in periodic and disordered DNA
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Hennig, D., Archilla, J. F. R., and Agarwal, J.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter - Soft Condensed Matter - Abstract
We study a model for polaron-like charge transport mechanism along DNA molecules with emphasis on the impact of parametrical and structural disorder. Our model Hamiltonian takes into account the coupling of the charge carrier to two different kind of modes representing fluctuating twist motions of the base pairs and H-bond distortions within the double helix structure of $\lambda-$DNA. Localized stationary states are constructed with the help of a nonlinear map approach for a periodic double helix and in the presence of intrinsic static parametrical and/or structural disorder reflecting the impact of ambient solvent coordinates. It is demonstrated that charge transport is mediated by moving polarons respectively breather compounds carrying not only the charge but causing also local temporal deformations of the helix structure through the traveling torsion and bond breather components illustrating the interplay of structure and function in biomolecules., Comment: 23 pages, 13 figures
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- 2003
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24. Nonlinear charge transport in DNA mediated by twist modes
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Palmero, F., Archilla, J. F. R., Hennig, D., and Romero, F. R.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter - Soft Condensed Matter ,Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
Recent works on localized charge transport along DNA, based on a three--dimensional, tight--binding model (Eur. Phys. J. B 30:211, 2002; Phys. D 180:256, 2003), suggest that charge transport is mediated by the coupling of the radial and electron variables. However, these works are based on a linear approximation of the distances among nucleotides, which forces for consistency the assumption that the parameter $\alpha$, that describes the coupling between the transfer integral and the distance between nucleotides is fairly small. In the present letter we perform an improvement of the model which allows larger values of $\alpha$, showing that there exist two very different regimes. Particulary, for large $\alpha$, the conclusions of the previous works are reversed and charge transport can be produced only by the coupling with the twisting modes., Comment: 15 pages, 6 figures
- Published
- 2003
25. Charge transport in a nonlinear, three--dimensional DNA model with disorder
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Archilla, J. F. R., Hennig, D., and Agarwal, J.
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Nonlinear Sciences - Pattern Formation and Solitons ,Condensed Matter - Soft Condensed Matter ,Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
We study the transport of charge due to polarons in a model of DNA which takes in account its 3D structure and the coupling of the electron wave function with the H--bond distortions and the twist motions of the base pairs. Perturbations of the ground states lead to moving polarons which travel long distances. The influence of parametric and structural disorder, due to the impact of the ambient, is considered, showing that the moving polarons survive to a certain degree of disorder. Comparison of the linear and tail analysis and the numerical results makes possible to obtain further information on the moving polaron properties., Comment: 9 pages, 2 figures. Proceedings of the conference on "Localization and energy transfer in nonlinear systems", June 17-21, 2002, San Lorenzo de El Escorial, Madrid, Spain. To be published
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- 2002
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26. Nonlinear chains inside walls
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Hennig, D. and Mulhern, C.
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- 2014
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27. Anharmonicity and Soliton-Mediated Transport: Thermal Solitons, Solectrons and Electric Transport in Nonlinear Conducting Lattices
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Ebeling, W., Velarde, M. G., Chetverikov, A. P., Hennig, D., Russo, Nino, editor, Antonchenko, Victor Ya., editor, and Kryachko, Eugene S., editor
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- 2009
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28. From strong chaos via weak chaos to regular behaviour: Optimal interplay between chaos and order
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Hennig, D., Mulhern, C., and Burbanks, A.D.
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- 2013
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29. Investigation of global and regional BWR instabilities with a four heated-channel Reduced Order Model
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Dykin, V., Demazière, C., Lange, C., and Hennig, D.
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- 2013
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30. Investigation of local BWR instabilities with a four heated-channel Reduced Order Model
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Dykin, V., Demazière, C., Lange, C., and Hennig, D.
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- 2013
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31. Dynamics of vibrational dissociation of a pseudo-cluster
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Hennig, D., Gabriel, H., and Peyrard, M., editor
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- 1995
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32. CLIP-170, a Cytoplasmic Linker Protein Mediating Interaction of Endosomes with Microtubules
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Scheel, J., Rickard, J. E., Pierre, P., Hennig, D., Karecla, P. I., Pepperkok, R., Joggerst-Thomalla, B., Sawyer, A., Parton, R. G., Kreis, T. E., Morré, D. James, editor, Howell, Kathryn E., editor, and Bergeron, John J. M., editor
- Published
- 1993
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33. Archivierung
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Plettenberg, H. D., Hennig, D., Lange, Lothar, editor, Seifert, Wolf, editor, Jaeger, Halvor, editor, and Klingmann, Ingrid, editor
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- 1992
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34. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
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Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, 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- Abstract
Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo
- Published
- 2019
35. Directing particle transport in a two-dimensional periodic potential landscape
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Hennig, D., Burbanks, A.D., and Osbaldestin, A.H.
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- 2010
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36. Collective transport of coupled particles
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Hennig, D. and Mulhern, C.
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- 2012
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37. Implications of heterogeneous inputs and connectivity on the synchronization in excitable networks
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Hennig, D. and Schimansky-Geier, L.
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- 2008
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38. Deterministic escape of a dimer over an anharmonic potential barrier
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Fugmann, S., Hennig, D., Martens, S., and Schimansky-Geier, L.
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- 2008
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39. Collective escape processes in many-particle systems
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Fugmann, S., Hennig, D., Schimansky-Geier, L., and Sokolov, I.M.
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- 2010
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40. Avalanches in a nonlinear oscillator chain in a periodic potential
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Hennig, D., Burbanks, A.D., and Osbaldestin, A.H.
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- 2010
- Full Text
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41. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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A, Pagett K, Pogson A, Price R, Price D, Procter K, Pye M, Redfearn H, Rewbury J, Ryding A, Sattar N, Sharp A, Shaw P, Simpson H, Smith W, Squire I, Storey R, Teenan M, Thomas H, Townend J, Trevelyan J, Wakeling J, Walukiewicz P, Wilkinson S, Zaman A, Acevedo L, Benton J, Abbate A, Aboufakher R, Acampora M, Acampora D, Aceto L, Acevedo B, Acheatel R, Adams M, Adams A, Ahmad I, Ahmed SH, Aish B, Akyea-Djamson A, Al Joundi T, Alcide P, Alfieri A, Alfonso T, Alfrey A, Allen J, Alllison DC, Almaliky T, Amos A, Angiolillo D, Antolick A, Ara M, Aragorn L, Arevalo S, Armas E, Arthur A, Asafu-Adjaye N, Ashcom T, Ashford M, Aslam A, Ather N, Atieh M, Aull L, Ayala M, Azizad M, Backer T, Baehl S, Bailey S, Bair S, Baker C, Ballmajo M, Pieretti HB, Baquero A, Barnett S, Baron S, Bartkowiak A, Bashir K, Beall K, Beauregard LA, Sarah S, Beckett L, Belejchak P, Bendelow T, Bender D, Benjamin S, Berdoff R, Berger V, Bergeron P, Berk M, Bernstein M, Binns Y, Bitzer V, Blahey M, Bloch S, Bluemel J, Boffetti P, Boley K, Bonner J, Boudreaux R, Boulanger K, Bradley A, Bramlet D, Bredlau C, Briggs S, Brousalis L, Brown S, Brown C, Buchannan C, Burke W, Burley T, Burton C, Burtt D, Byars W, Caballero-Valiente B, Carr K, Halliwell TC, Castillo J, Cei L, Cerda L, Chambers J, Chamblee T, Chattin W, Chee L, Chen YC, Cherlin R, Cheung D, Chiodi L, Christensen L, Christenson S, Cislowski D, Clavier-Firmin C, Colfer H, Colvin T, Cosgrove N, Covert C, Cox B, Cox R, Craig W, Crandall L, Crepps K, Cromer M, Cruz H, Cruz H, Cruz M, Cucher F, Damron M, Dave K, Dave B, Davis M, Davis B, Dawkins-Hughes S, Dean J, Debnam S, Defosse C, Dehning M, Dela Llana A, Dellorso M, Denham D, Desalle D, Dettmer M, Dhawan M, Diago M, Dicken T, Diederich C, Diederich M, Diehl R, Digangi D, Diller P, Dimattia M, Dodds G, Doggett J, Donahue K, Doughty L, Dragutksy B, Dreese M, Dunhurst F, Dunn D, Dutka C, Earl J, Eaton C, Eaves W, Ebeling K, Eder F, Edgerton L, Edillo C, Edwards J, Edwards T, Einhorn D, El Hafi S, 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Hodnett P, Hoffman M, Hogan C, Holmes Z, Rees DH, Hotchkiss D, Huang P, Humbert J, Hutchens E, Iachini K, Ibarra M, Igbokidi O, Ilahi T, Imbrognio M, Ipp E, Iteld B, Jacques G, Jafri A, Jafry B, Jardula M, Jefferson D, Jenkins R, Johnson E, Johnson J, Jones S, Kawahara M, Kelehan S, Kelly R, Kendall T, Kereiakes D, Khan M, Khan S, Kick J, Kimmel M, King T, King A, Kirkland S, Kissel S, Kitchens D, Klein P, Klugherz B, Korban E, Koren M, Korte M, Kostis J, Kotek L, Kozak M, Kreutter F, Kusnick B, Labovitz R, Lail J, Lamance J, Lamas G, Lambert J, Lambert C, Landzberg J, Langdon J, Lavoie W, Ledger G, Lee T, Lee K, Lehman R, Leimbach W, Lennard M, Lepor N, Lester F, Levin P, Levinson L, Lewis D, Lillo J, Link L, Long C, Longaker R, Lorch G, Lucksinger G, Lynd S, Rhudy JM, Madder R, Magness K, Maheshwari A, Alan A, Malek M, Maletz L, Malhotra V, Malhotra S, Mandviwala M, Mani CK, Manuel J, Marchelletta N, Marshall L, Marsters M, Martin L, Martinez E, Mavromatis K, Maynard R, Mays M, Mays 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M., Everett, B. M., Thuren, T., Macfadyen, J. G., Chang, W. H., Ballantyne, C., FONSECA E PIRES, CARLOS EDUARDO, Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Rossi, P. R. F., Troquay, R. P. T., Libby, P., Glynn R., J, CANTOS Trial, Group, Perrone, Filardi, P, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
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0301 basic medicine ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,c-reactive protein ,Randomized controlled trial ,law ,Cardiovascular Disease ,middle aged ,double-blind method ,antibodies ,Myocardial infarction ,humans ,Stroke ,interleukin-1beta ,biology ,Antibodies, Monoclonal ,drug ,General Medicine ,Lipid ,Aged ,anti-inflammatory agents ,monoclonal ,humanized ,atherosclerosis ,cardiovascular diseases ,dose-response relationship ,female ,incidence ,infections ,lipids ,male ,myocardial infarction ,neutropenia ,secondary prevention ,stroke ,Anti-Inflammatory Agent ,aged ,Editorial ,Atherosclerosi ,Monoclonal ,Human ,medicine.drug ,medicine.medical_specialty ,Neutropenia ,Antibodies, Monoclonal, Humanized ,Infections ,Placebo ,antibodies, monoclonal ,dose-response relationship, drug ,infection ,medicine (all) ,03 medical and health sciences ,Internal medicine ,medicine ,Dose-Response Relationship, Drug ,business.industry ,Antiinflammatory Therapy, Canakinumab, for Atherosclerotic Disease ,C-reactive protein ,medicine.disease ,Surgery ,Canakinumab ,030104 developmental biology ,biology.protein ,business - Abstract
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.)
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- 2017
42. Localization properties of electronic states in a polaron model of poly(dG)-poly(dC) and poly(dA)-poly(dT) DNA polymers
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Yamada, H., Starikov, E. B., Hennig, D., and Archilla, J. F. R.
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- 2005
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43. Charge Transport in Poly(dG)–Poly(dC) and Poly(dA)–Poly(dT) DNA Polymers
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Hennig, D., Starikov, E. B., Archilla, J. F. R., and Palmero, F.
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- 2004
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44. Formation and propagation of oscillating bubbles in DNA initiated by structural distortions
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Hennig, D.
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- 2004
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45. Control of electron transfer in disordered DNA under the impact of viscous damping and an external periodic field
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Hennig, D.
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- 2002
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46. Enhanced energy transport in polypeptide chains under the influence of the pulsating protein matrix
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Hennig, D.
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- 2001
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47. Next-nearest neighbor interaction and localized solutions of polymer chains
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Hennig, D.
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- 2001
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48. List of Contributors
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Amari, Shinji, primary, Archilla, J.F.R., additional, Beratan, David N., additional, Bickelhaupt, F. Matthias, additional, Bredenberg, Johan, additional, Bulla, Ralf, additional, Calzolari, Arrigo, additional, Chuman, Hiroshi, additional, Claiden, Peter, additional, Cox, Daniel L., additional, Cramer, Tobias, additional, Crawshaw, Jane, additional, Cuniberti, Gianaurelio, additional, Dahlberg, Martin, additional, Davies, Owen R., additional, Elliott, James, additional, Endres, Robert G., additional, Fedorov, Dmitri G., additional, Felice, Rosa Di, additional, Fischer, B., additional, Fukuzawa, Kaori, additional, Gao, Yi Qin, additional, Gordon, Heather L., additional, Goto, Hitoshi, additional, Guerra, Célia Fonseca, additional, Gutierrez, Rafael, additional, Hamada, Michiaki, additional, Hennig, D., additional, Hübsch, Arnd, additional, Inadomi, Yuichi, additional, Inagaki, Yuichiro, additional, Inglesfield, John E., additional, Ito, Masakatsu, additional, Kamakura, Toshiyuki, additional, Karplus, Martin, additional, Kitaura, Kazuo, additional, Koslowski, Thorsten, additional, Kundrotas, Petras J., additional, Kurita, Noriyuki, additional, Laaksonen, Aatto, additional, Lakhno, Victor D., additional, Lee, K.H., additional, Lewis, J.P., additional, Lin, Jianping, additional, Lohikoski, Raimo A., additional, Mark, Pekka, additional, Marsh, R., additional, Merlitz, H., additional, Mochizuki, Yuji, additional, Nagashima, Umpei, additional, Nakajima, Yoshihiro, additional, Nakano, Tatsuya, additional, Nakayama, Naofumi, additional, Natsume, Takayuki, additional, Nilsson, Lennart, additional, Nishikawa, Takeshi, additional, Obata, Sigeaki, additional, Pinak, Miroslav, additional, Popovic, Dragan M., additional, Quenneville, Jason, additional, Quintilla, Aina, additional, Römer, R.A., additional, Rothstein, Stuart M., additional, Sato, Mitsuhisa, additional, Schmitz, Matthias, additional, Schug, A., additional, Sengoku, Yasuo, additional, Singh, Rajiv R.P., additional, Skourtis, Spiros S., additional, Starikov, Evgeni B., additional, Stuchebrukhov, Alexei A., additional, Tanaka, Shigenori, additional, Tavan, Paul, additional, Utz, Nadine, additional, Verma, A., additional, Voityuk, Alexander A., additional, Wang, H., additional, Watanabe, Toshio, additional, Wenzel, Wolfgang, additional, Windle, Alan, additional, and Yang, Wei, additional
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- 2006
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49. Polaronic charge transport mechanism in DNA
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Hennig, D., primary and Archilla, J.F.R., additional
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- 2006
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50. Natural circulation and stability performance of BWRs (NACUSP)
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Aguirre, C., Caruge, D., Castrillo, F., Dominicus, G., Geutjes, A.J., Saldo, V., van der Hagen, T.H.J.J., Hennig, D., Huggenberger, M., Ketelaar, K.C.J., Manera, A., Munoz-Cobo, J.L., Prasser, H.-M., Rohde, U., Royer, E., and Yadigaroglu, G.
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- 2005
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Catalog
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