1,896 results on '"Henning, J. A."'
Search Results
2. A Measurement of Gravitational Lensing of the Cosmic Microwave Background Using SPT-3G 2018 Data
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Pan, Z., Bianchini, F., Wu, W. L. K., Ade, P. A. R., Ahmed, Z., Anderes, E., Anderson, A. J., Ansarinejad, B., Archipley, M., Aylor, K., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Benabed, K., Bender, A. N., Benson, B. A., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Camphuis, E., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Chichura, P. M., Cho, H. -M., Chou, T. -L., Cliche, J. -F., Coerver, A., Crawford, T. M., Cukierman, A., Daley, C., de Haan, T., Denison, E. V., Dibert, K. R., Ding, J., Dobbs, M. A., Doussot, A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fichman, K., Foster, A., Fu, J., Galli, S., Gambrel, A. E., Gardner, R. W., Ge, F., Goeckner-Wald, N., Gualtieri, R., Guidi, F., Guns, S., Gupta, N., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Huang, N., Irwin, K. D., Jeong, O., Jonas, M., Jones, A., Kéruzoré, F., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Levy, K., Lowitz, A. E., Lu, C., Maniyar, A., Menanteau, F., Meyer, S. S., Michalik, D., Millea, M., Montgomery, J., Nadolski, A., Nakato, Y., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Paschos, P., Pearson, J., Posada, C. M., Prabhu, K., Quan, W., Raghunathan, S., Rahimi, M., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Ruhl, J. E., Sayre, J. T., Schiappucci, E., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Takakura, S., Tandoi, C., Thompson, K. L., Thorne, B., Trendafilova, C., Tucker, C., Umilta, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., Young, M. R., and Zebrowski, J. A.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a measurement of gravitational lensing over 1500 deg$^2$ of the Southern sky using SPT-3G temperature data at 95 and 150 GHz taken in 2018. The lensing amplitude relative to a fiducial Planck 2018 $\Lambda$CDM cosmology is found to be $1.020\pm0.060$, excluding instrumental and astrophysical systematic uncertainties. We conduct extensive systematic and null tests to check the robustness of the lensing measurements, and report a minimum-variance combined lensing power spectrum over angular multipoles of $50
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- 2023
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3. Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors
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Ng, Martin Y., Wang, Huanchen, Zhang, Haibo, Prucker, Isabel, Perera, Lalith, Goncharova, Ekaterina, Wamiru, Antony, Jessen, Henning J., Stanley, Robin E., Shears, Stephen B., Luo, Ji, O'Keefe, Barry R., and Wilson, Brice A.P.
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- 2025
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4. Inositol pyrophosphate catabolism by three families of phosphatases regulates plant growth and development.
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Florian Laurent, Simon M Bartsch, Anuj Shukla, Felix Rico-Resendiz, Daniel Couto, Christelle Fuchs, Joël Nicolet, Sylvain Loubéry, Henning J Jessen, Dorothea Fiedler, and Michael Hothorn
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Genetics ,QH426-470 - Abstract
Inositol pyrophosphates (PP-InsPs) are nutrient messengers whose cellular levels are precisely regulated. Diphosphoinositol pentakisphosphate kinases (PPIP5Ks) generate the active signaling molecule 1,5-InsP8. PPIP5Ks harbor phosphatase domains that hydrolyze PP-InsPs. Plant and Fungi Atypical Dual Specificity Phosphatases (PFA-DSPs) and NUDIX phosphatases (NUDTs) are also involved in PP-InsP degradation. Here, we analyze the relative contributions of the three different phosphatase families to plant PP-InsP catabolism. We report the biochemical characterization of inositol pyrophosphate phosphatases from Arabidopsis and Marchantia polymorpha. Overexpression of different PFA-DSP and NUDT enzymes affects PP-InsP levels and leads to stunted growth phenotypes in Arabidopsis. nudt17/18/21 knock-out mutants have altered PP-InsP pools and gene expression patterns, but no apparent growth defects. In contrast, Marchantia polymorpha Mppfa-dsp1ge, Mpnudt1ge and Mpvip1ge mutants display severe growth and developmental phenotypes and associated changes in cellular PP-InsP levels. Analysis of Mppfa-dsp1geand Mpvip1ge mutants supports a role for PP-InsPs in Marchantia phosphate signaling, and additional functions in nitrate homeostasis and cell wall biogenesis. Simultaneous elimination of two phosphatase activities enhanced the observed growth phenotypes. Taken together, PPIP5K, PFA-DSP and NUDT inositol pyrophosphate phosphatases regulate growth and development by collectively shaping plant PP-InsP pools.
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- 2024
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5. Asteroid Measurements at Millimeter Wavelengths with the South Pole Telescope
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Chichura, P. M., Foster, A., Patel, C., Ossa-Jaen, N., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Archipley, M., Austermann, J. E., Avva, J. S., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Beall, J. A., Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Chiang, H. C., Cho, H. -M., Chou, T-L., Citron, R., Cliche, J. -F., Crawford, T. M., Crites, A. T., Cukierman, A., Daley, C. M., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gallicchio, J., Gambrel, A. E., Gardner, R. W., George, E. M., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., de Haan, T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Lu, C., Marrone, D. P., McMahon, J. J., Meyer, S. S., Michalik, D., Millea, M., Mocanu, L. M., Montgomery, J., Moran, C. Corbett, Nadolski, A., Natoli, T., Nguyen, H., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Patil, S., Pearson, J., Phadke, K. A., Posada, C. M., Prabhu, K., Pryke, C., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Schiappucci, E., Shirokoff, E., Sievers, C., Smecher, G., Sobrin, J. A., Springmann, A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present the first measurements of asteroids in millimeter wavelength (mm) data from the South Pole Telescope (SPT), which is used primarily to study the cosmic microwave background (CMB). We analyze maps of two $\sim270$ deg$^2$ sky regions near the ecliptic plane, each observed with the SPTpol camera $\sim100$ times over one month. We subtract the mean of all maps of a given field, removing static sky signal, and then average the mean-subtracted maps at known asteroid locations. We detect three asteroids$\text{ -- }$(324) Bamberga, (13) Egeria, and (22) Kalliope$\text{ -- }$with signal-to-noise ratios (S/N) of 11.2, 10.4, and 6.1, respectively, at 2.0 mm (150 GHz); we also detect (324) Bamberga with S/N of 4.1 at 3.2 mm (95 GHz). We place constraints on these asteroids' effective emissivities, brightness temperatures, and light curve modulation amplitude. Our flux density measurements of (324) Bamberga and (13) Egeria roughly agree with predictions, while our measurements of (22) Kalliope suggest lower flux, corresponding to effective emissivities of $0.66 \pm 0.11$ at 2.0 mm and $<0.47$ at 3.2mm. We predict the asteroids detectable in other SPT datasets and find good agreement with detections of (772) Tanete and (1093) Freda in recent data from the SPT-3G camera, which has $\sim10 \times$ the mapping speed of SPTpol. This work is the first focused analysis of asteroids in data from CMB surveys, and it demonstrates we can repurpose historic and future datasets for asteroid studies. Future SPT measurements can help constrain the distribution of surface properties over a larger asteroid population., Comment: 21 pages, 9 figures
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- 2022
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6. Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase
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Shreya Ghosh, Ana M. Sanchez, Beate Schwer, Isabel Prucker, Nikolaus Jork, Henning J. Jessen, and Stewart Shuman
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inositol pyrophosphatase ,inorganic polyphosphatase ,Nudix hydrolase ,phosphate homeostasis ,Schizosaccharomyces pombe ,Microbiology ,QR1-502 - Abstract
ABSTRACT Inositol pyrophosphate 1,5-IP8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1, pho84, and tgp1, via its action as an agonist of precocious termination of transcription of the upstream lncRNAs that repress PHO mRNA synthesis. 1,5-IP8 levels are dictated by a balance between the Asp1 N-terminal kinase domain that converts 5-IP7 to 1,5-IP8 and three inositol pyrophosphatases—the Asp1 C-terminal domain (a histidine acid phosphatase), Siw14 (a cysteinyl-phosphatase), and Aps1 (a Nudix enzyme). In this study, we report the biochemical and genetic characterization of Aps1 and an analysis of the effects of Asp1, Siw14, and Aps1 mutations on cellular inositol pyrophosphate levels. We find that Aps1’s substrate repertoire embraces inorganic polyphosphates, 5-IP7, 1-IP7, and 1,5-IP8. Aps1 displays a ~twofold preference for hydrolysis of 1-IP7 versus 5-IP7 and aps1∆ cells have twofold higher levels of 1-IP7 vis-à-vis wild-type cells. While neither Aps1 nor Siw14 is essential for growth, an aps1∆ siw14∆ double mutation is lethal on YES medium. This lethality is a manifestation of IP8 toxicosis, whereby excessive 1,5-IP8 drives derepression of tgp1, leading to Tgp1-mediated uptake of glycerophosphocholine. We were able to recover an aps1∆ siw14∆ mutant on ePMGT medium lacking glycerophosphocholine and to suppress the severe growth defect of aps1∆ siw14∆ on YES by deleting tgp1. However, the severe growth defect of an aps1∆ asp1-H397A strain could not be alleviated by deleting tgp1, suggesting that 1,5-IP8 levels in this double-pyrophosphatase mutant exceed a threshold beyond which overzealous termination affects other genes, which results in cytotoxicity.IMPORTANCERepression of the fission yeast PHO genes tgp1, pho1, and pho84 by lncRNA-mediated interference is sensitive to changes in the metabolism of 1,5-IP8, a signaling molecule that acts as an agonist of precocious lncRNA termination. 1,5-IP8 is formed by phosphorylation of 5-IP7 and catabolized by inositol pyrophosphatases from three distinct enzyme families: Asp1 (a histidine acid phosphatase), Siw14 (a cysteinyl phosphatase), and Aps1 (a Nudix hydrolase). This study entails a biochemical characterization of Aps1 and an analysis of how Asp1, Siw14, and Aps1 mutations impact growth and inositol pyrophosphate pools in vivo. Aps1 catalyzes hydrolysis of inorganic polyphosphates, 5-IP7, 1-IP7, and 1,5-IP8 in vitro, with a ~twofold preference for 1-IP7 over 5-IP7. aps1∆ cells have twofold higher levels of 1-IP7 than wild-type cells. An aps1∆ siw14∆ double mutation is lethal because excessive 1,5-IP8 triggers derepression of tgp1, leading to toxic uptake of glycerophosphocholine.
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- 2024
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7. Control of a chemical chaperone by a universally conserved ATPase
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Hong Jiang, Martin Milanov, Gabriela Jüngert, Larissa Angebauer, Clara Flender, Eva Smudde, Fabian Gather, Tanja Vogel, Henning J. Jessen, and Hans-Georg Koch
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Applied sciences ,Biotechnology ,Medical biochemistry ,Science - Abstract
Summary: The universally conserved YchF/Ola1 ATPases regulate stress response pathways in prokaryotes and eukaryotes. Deletion of YchF/Ola1 leads to increased resistance against environmental stressors, such as reactive oxygen species, while their upregulation is associated with tumorigenesis in humans. The current study shows that in E. coli, the absence of YchF stimulates the synthesis of the alternative sigma factor RpoS by a transcription-independent mechanism. Elevated levels of RpoS then enhance the transcription of major stress-responsive genes. In addition, the deletion of ychF increases the levels of polyphosphate kinase, which in turn boosts the production of the evolutionary conserved and ancient chemical chaperone polyphosphate. This potentially provides a unifying concept for the increased stress resistance in bacteria and eukaryotes upon YchF/Ola1 deletion. Intriguingly, the simultaneous deletion of ychF and the polyphosphate-degrading enzyme exopolyphosphatase causes synthetic lethality in E. coli, demonstrating that polyphosphate production needs to be fine-tuned to prevent toxicity.
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- 2024
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8. Optimizing treatment management of trastuzumab deruxtecan in clinical practice of breast cancer
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Rugo, HS, Bianchini, G, Cortes, J, Henning, J-W, and Untch, M
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Clinical Trials and Supportive Activities ,Breast Cancer ,Patient Safety ,Clinical Research ,Cancer ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Alopecia ,Antibodies ,Monoclonal ,Humanized ,Breast Neoplasms ,Camptothecin ,Fatigue ,Female ,Humans ,Immunoconjugates ,Lung Diseases ,Interstitial ,Nausea ,Neutropenia ,Trastuzumab ,Ventricular Dysfunction ,Left ,Vomiting ,trastuzumab deruxtecan ,adverse event ,breast cancer ,nausea ,vomiting ,interstitial lung disease - Abstract
IntroductionThe antibody-drug conjugate trastuzumab deruxtecan (T-DXd) targets human epidermal growth factor receptor 2 (HER2) and has been evaluated in patients with HER2-positive unresectable/metastatic breast cancer in the phase II DESTINY-Breast01 trial (NCT03248492; DS8201-A-U201) and the randomized phase III DESTINY-Breast03 trial (NCT03529110; DS8201-A-U302). Approximately 20 additional studies are ongoing in breast cancer, including HER2-low breast cancer, and other solid tumor types within the DESTINY trial program. T-DXd has demonstrated a generally manageable safety profile, with low-grade hematologic and gastrointestinal adverse events (AEs) among the most common; interstitial lung disease (ILD)/pneumonitis has been observed in patients receiving T-DXd and can be severe. This review discusses the management of common AEs and AEs of special interest in patients with HER2-positive unresectable/metastatic breast cancer, including nausea and vomiting, neutropenia, infusion-related reactions, alopecia, fatigue, ILD/pneumonitis, and left ventricular dysfunction.MethodsExpert opinions, institutional protocols, and strategies to help optimize AE management and maximize the potential benefits of T-DXd in patients with breast cancer from five oncologists treating patients with T-DXd in North America and Europe are discussed.ResultsProphylaxis for nausea and vomiting and proactive management of ILD/pneumonitis are especially important in treating patients with T-DXd. Management strategies for other T-DXd-related AEs of interest (e.g. neutropenia, infusion-related reactions, alopecia, fatigue, and left ventricular dysfunction) are also discussed.ConclusionsThis review provides context for understanding the usage, monitoring, and management practices of other health care providers and institutions with experience using T-DXd to help with safe and effective management of T-DXd-related AEs, particularly since the duration of T-DXd treatment may be quite long. Proper management of T-DXd-related AEs will allow optimal exposure and benefit from T-DXd and will help avoid premature discontinuation or improper dose reductions.
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- 2022
9. The Design and Integrated Performance of SPT-3G
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Sobrin, J. A., Anderson, A. J., Bender, A. N., Benson, B. A., Dutcher, D., Foster, A., Goeckner-Wald, N., Montgomery, J., Nadolski, A., Rahlin, A., Ade, P. A. R., Ahmed, Z., Anderes, E., Archipley, M., Austermann, J. E., Avva, J. S., Aylor, K., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Benabed, K., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Cho, H. -M., Chou, T. -L., Cliche, J. -F., Crawford, T. M., Cukierman, A., Daley, C., de Haan, T., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gambrel, A. E., Gardner, R. W., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Lu, C., Meyer, S. S., Michalik, D., Millea, M., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Prabhu, K., Quan, W., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Saliwanchik, B., Sayre, J. T., Schiappucci, E., Shirokoff, E., Smecher, G., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
SPT-3G is the third survey receiver operating on the South Pole Telescope dedicated to high-resolution observations of the cosmic microwave background (CMB). Sensitive measurements of the temperature and polarization anisotropies of the CMB provide a powerful dataset for constraining cosmology. Additionally, CMB surveys with arcminute-scale resolution are capable of detecting galaxy clusters, millimeter-wave bright galaxies, and a variety of transient phenomena. The SPT-3G instrument provides a significant improvement in mapping speed over its predecessors, SPT-SZ and SPTpol. The broadband optics design of the instrument achieves a 430 mm diameter image plane across observing bands of 95 GHz, 150 GHz, and 220 GHz, with 1.2 arcmin FWHM beam response at 150 GHz. In the receiver, this image plane is populated with 2690 dual-polarization, tri-chroic pixels (~16000 detectors) read out using a 68X digital frequency-domain multiplexing readout system. In 2018, SPT-3G began a multiyear survey of 1500 deg$^{2}$ of the southern sky. We summarize the unique optical, cryogenic, detector, and readout technologies employed in SPT-3G, and we report on the integrated performance of the instrument., Comment: 25 pages, 11 figures. Accepted for publication in ApJS
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- 2021
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10. Fused Deposition Modeling of Chemically Resistant Microfluidic Chips in Polyvinylidene Fluoride
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Christof Rein, Leonhard Hambitzer, Zahra Soraya, Han Zhang, Henning J. Jessen, Frederik Kotz-Helmer, and Bastian E. Rapp
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3D printing ,additive manufacturing ,fused deposition modeling ,microfluidics ,polyvinylidene fluoride ,lab-on-a-chip ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
Fused deposition modeling (FDM) is well suited for microfluidic prototyping due to its low investment cost and a wide range of accessible materials. Nevertheless, most commercial FDM materials exhibit low chemical and thermal stability. This reduces the scope of applications and limits their use in research and development, especially for on-chip chemical synthesis. In this paper, we present FDM fabrication of microfluidic chips with polyvinylidene fluoride (PVDF) for applications that require high thermal or chemical resistance. Embedded microchannels with a minimum channel width and heights of ~200 µm × 200 µm were fabricated, and the resistance against common solvents was analyzed. A procedure was developed to increase the optical transmission to result in translucent components by printing on glass. Chips for fluid mixing were printed, as well as microreactors that were packed with a catalytically active phase and used for acetal deprotection with a conversion of more than 99%. By expanding the use of fluorinated polymers to FDM printing, previously challenging microfluidic applications will be conducted with ease at the lab scale.
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- 2024
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11. Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8
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Li, Xingyao, Kirkpatrick, Regan B., Wang, Xiaodong, Tucker, Charles J., Shukla, Anuj, Jessen, Henning J., Wang, Huanchen, Shears, Stephen B., and Gu, Chunfang
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- 2024
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12. Structures of 3-acetylpyridine adenine dinucleotide and ADP-ribose bound to the electron input module of respiratory complex I
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Wohlwend, Daniel, Mérono, Luca, Bucka, Sarah, Ritter, Kevin, Jessen, Henning J., and Friedrich, Thorsten
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- 2024
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13. Performance and characterization of the SPT-3G digital frequency-domain multiplexed readout system using an improved noise and crosstalk model
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Montgomery, J., Ade, P. A. R., Ahmed, Z., Anderes, E., Anderson, A. J., Archipley, M., Avva, J. S., Aylor, K., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Cho, H. -M., Chou, T. -L., Cliche, J. -F., Crawford, T. M., Cukierman, A., Daley, C., de Haan, T., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Elleflot, T., Everett, W., Feng, C., Ferguson, K. R., Foster, A., Fu, J., Galli, S., Gambrel, A. E., Gardner, R. W., Goeckner-Wald, N., Groh, J. C., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holzapfel, W. L., Hood, J. C., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Lu, C., Meyer, S. S., Michalik, D., Millea, M., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Prabhu, K., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Sayre, J. T., Schiappucci, E., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The third generation South Pole Telescope camera (SPT-3G) improves upon its predecessor (SPTpol) by an order of magnitude increase in detectors on the focal plane. The technology used to read out and control these detectors, digital frequency-domain multiplexing (DfMUX), is conceptually the same as used for SPTpol, but extended to accommodate more detectors. A nearly 5x expansion in the readout operating bandwidth has enabled the use of this large focal plane, and SPT-3G performance meets the forecasting targets relevant to its science objectives. However, the electrical dynamics of the higher-bandwidth readout differ from predictions based on models of the SPTpol system due to the higher frequencies used, and parasitic impedances associated with new cryogenic electronic architecture. To address this, we present an updated derivation for electrical crosstalk in higher-bandwidth DfMUX systems, and identify two previously uncharacterized contributions to readout noise, which become dominant at high bias frequency. The updated crosstalk and noise models successfully describe the measured crosstalk and readout noise performance of SPT-3G. These results also suggest specific changes to warm electronics component values, wire-harness properties, and SQUID parameters, to improve the readout system for future experiments using DfMUX, such as the LiteBIRD space telescope., Comment: Accepted to the Journal of Astronomical Telescopes, Instruments, and Systems
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- 2021
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14. Constraints on $\Lambda$CDM Extensions from the SPT-3G 2018 $EE$ and $TE$ Power Spectra
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Balkenhol, L., Dutcher, D., Ade, P. A. R., Ahmed, Z., Anderes, E., Anderson, A. J., Archipley, M., Avva, J. S., Aylor, K., Barry, P. S., Thakur, R. Basu, Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Cho, H. -M., Chou, T. -L., Cliche, J. -F., Crawford, T. M., Cukierman, A., Daley, C., de Haan, T., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Everett, W., Feng, C., Ferguson, K. R., Foster, A., Fu, J., Galli, S., Gambrel, A. E., Gardner, R. W., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Lu, C., Meyer, S. S., Michalik, D., Millea, M., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Prabhu, K., Quan, W., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Sayre, J. T., Schiappucci, E., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present constraints on extensions to the $\Lambda$CDM cosmological model from measurements of the $E$-mode polarization auto-power spectrum and the temperature-$E$-mode cross-power spectrum of the cosmic microwave background (CMB) made using 2018 SPT-3G data. The extensions considered vary the primordial helium abundance, the effective number of relativistic degrees of freedom, the sum of neutrino masses, the relativistic energy density and mass of a sterile neutrino, and the mean spatial curvature. We do not find clear evidence for any of these extensions, from either the SPT-3G 2018 dataset alone or in combination with baryon acoustic oscillation and \textit{Planck} data. None of these model extensions significantly relax the tension between Hubble-constant, $H_0$, constraints from the CMB and from distance-ladder measurements using Cepheids and supernovae. The addition of the SPT-3G 2018 data to \textit{Planck} reduces the square-root of the determinants of the parameter covariance matrices by factors of $1.3 - 2.0$ across these models, signaling a substantial reduction in the allowed parameter volume. We also explore CMB-based constraints on $H_0$ from combined SPT, \textit{Planck}, and ACT DR4 datasets. While individual experiments see some indications of different $H_0$ values between the $TT$, $TE$, and $EE$ spectra, the combined $H_0$ constraints are consistent between the three spectra. For the full combined datasets, we report $H_0 = 67.49 \pm 0.53\,\mathrm{km\,s^{-1}\,Mpc^{-1}}$, which is the tightest constraint on $H_0$ from CMB power spectra to date and in $4.1\,\sigma$ tension with the most precise distance-ladder-based measurement of $H_0$. The SPT-3G survey is planned to continue through at least 2023, with existing maps of combined 2019 and 2020 data already having $\sim3.5\times$ lower noise than the maps used in this analysis., Comment: Submitted to PRD; 19 pages, 7 figures
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- 2021
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15. Detection of Galactic and Extragalactic Millimeter-Wavelength Transient Sources with SPT-3G
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Guns, S., Foster, A., Daley, C., Rahlin, A., Whitehorn, N., Ade, P. A. R., Ahmed, Z., Anderes, E., Anderson, A. J., Archipley, M., Avva, J. S., Aylor, K., Balkenhol, L., Barry, P. S., Thakur, R. Basu, Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Cho, H. -M., Chou, T. -L., Cliche, J. -F., Crawford, T. M., Cukierman, A., de Haan, T., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Feng, C., Ferguson, K. R., Fu, J., Galli, S., Gambrel, A. E., Gardner, R. W., Goeckner-Wald, N., Gualtieri, R., Gupta, N., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Lu, C., Marrone, D. P., Meyer, S. S., Michalik, D., Millea, M., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Pearson, J., Phadke, K. A., Posada, C. M., Prabhu, K., Quan, W., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Sayre, J. T., Schiappucci, E., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Vieira, J. D., Wang, G., Wu, W. L. K., Yefremenko, V., Yoon, K. W., Young, M. R., and Zhang, L.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
High-angular-resolution cosmic microwave background experiments provide a unique opportunity to conduct a survey of time-variable sources at millimeter wavelengths, a population which has primarily been understood through follow-up measurements of detections in other bands. Here we report the first results of an astronomical transient survey with the South Pole Telescope (SPT) using the SPT-3G camera to observe 1500 square degrees of the southern sky. The observations took place from March to November 2020 in three bands centered at 95, 150, and 220 GHz. This survey yielded the detection of fifteen transient events from sources not previously detected by the SPT. The majority are associated with variable stars of different types, expanding the number of such detected flares by more than a factor of two. The stellar flares are unpolarized and bright, in some cases exceeding 1 Jy, and have durations from a few minutes to several hours. Another population of detected events last for 2--3 weeks and appear to be extragalactic in origin. Though data availability at other wavelengths is limited, we find evidence for concurrent optical activity for two of the stellar flares. Future data from SPT-3G and forthcoming instruments will provide real-time detection of millimeter-wave transients on timescales of minutes to months., Comment: 14 pages, 9 figures; accepted to ApJ 5/27
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- 2021
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16. Measurements of the E-Mode Polarization and Temperature-E-Mode Correlation of the CMB from SPT-3G 2018 Data
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Dutcher, D., Balkenhol, L., Ade, P. A. R., Ahmed, Z., Anderes, E., Anderson, A. J., Archipley, M., Avva, J. S., Aylor, K., Barry, P. S., Thakur, R. Basu, Benabed, K., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Bouchet, F. R., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Chaubal, P., Chen, G., Cho, H. -M., Chou, T. -L., Cliche, J. -F., Crawford, T. M., Cukierman, A., Daley, C., de Haan, T., Denison, E. V., Dibert, K., Ding, J., Dobbs, M. A., Everett, W., Feng, C., Ferguson, K. R., Foster, A., Fu, J., Galli, S., Gambrel, A. E., Gardner, R. W., Goeckner-Wald, N., Gualtieri, R., Guns, S., Gupta, N., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Hivon, E., Holder, G. P., Holzapfel, W. L., Hood, J. C., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Lu, C., Meyer, S. S., Michalik, D., Millea, M., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Prabhu, K., Quan, W., Raghunathan, S., Rahlin, A., Reichardt, C. L., Riebel, D., Riedel, B., Rouble, M., Ruhl, J. E., Sayre, J. T., Schiappucci, E., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Thorne, B., Tucker, C., Umilta, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present measurements of the $E$-mode ($EE$) polarization power spectrum and temperature-$E$-mode ($TE$) cross-power spectrum of the cosmic microwave background using data collected by SPT-3G, the latest instrument installed on the South Pole Telescope. This analysis uses observations of a 1500 deg$^2$ region at 95, 150, and 220 GHz taken over a four month period in 2018. We report binned values of the $EE$ and $TE$ power spectra over the angular multipole range $300 \le \ell < 3000$, using the multifrequency data to construct six semi-independent estimates of each power spectrum and their minimum-variance combination. These measurements improve upon the previous results of SPTpol across the multipole ranges $300 \le \ell \le 1400$ for $EE$ and $300 \le \ell \le 1700$ for $TE$, resulting in constraints on cosmological parameters comparable to those from other current leading ground-based experiments. We find that the SPT-3G dataset is well-fit by a $\Lambda$CDM cosmological model with parameter constraints consistent with those from Planck and SPTpol data. From SPT-3G data alone, we find $H_0 = 68.8 \pm 1.5 \mathrm{km\,s^{-1}\,Mpc^{-1}}$ and $\sigma_8 = 0.789 \pm 0.016$, with a gravitational lensing amplitude consistent with the $\Lambda$CDM prediction ($A_L = 0.98 \pm 0.12$). We combine the SPT-3G and the Planck datasets and obtain joint constraints on the $\Lambda$CDM model. The volume of the 68% confidence region in six-dimensional $\Lambda$CDM parameter space is reduced by a factor of 1.5 compared to Planck-only constraints, with only slight shifts in central values. We note that the results presented here are obtained from data collected during just half of a typical observing season with only part of the focal plane operable, and that the active detector count has since nearly doubled for observations made with SPT-3G after 2018.
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- 2021
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17. Optimal CMB Lensing Reconstruction and Parameter Estimation with SPTpol Data
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Millea, M., Daley, C. M., Chou, T-L., Anderes, E., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Goeckner-Wald, N., Guns, S., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., McMahon, J. J., Meyer, S. S., Mocanu, L. M., Montgomery, J., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Smecher, G., Stark, A. A., Thorne, B., Tucker, C., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We perform the first simultaneous Bayesian parameter inference and optimal reconstruction of the gravitational lensing of the cosmic microwave background (CMB), using 100 deg$^2$ of polarization observations from the SPTpol receiver on the South Pole Telescope. These data reach noise levels as low as 5.8 $\mu$K-arcmin in polarization, which are low enough that the typically used quadratic estimator (QE) technique for analyzing CMB lensing is significantly sub-optimal. Conversely, the Bayesian procedure extracts all lensing information from the data and is optimal at any noise level. We infer the amplitude of the gravitational lensing potential to be $A_\phi\,{=}\,0.949\,{\pm}\,0.122$ using the Bayesian pipeline, consistent with our QE pipeline result, but with 17\% smaller error bars. The Bayesian analysis also provides a simple way to account for systematic uncertainties, performing a similar job as frequentist "bias hardening," and reducing the systematic uncertainty on $A_\phi$ due to polarization calibration from almost half of the statistical error to effectively zero. Finally, we jointly constrain $A_\phi$ along with $A_{\rm L}$, the amplitude of lensing-like effects on the CMB power spectra, demonstrating that the Bayesian method can be used to easily infer parameters both from an optimal lensing reconstruction and from the delensed CMB, while exactly accounting for the correlation between the two. These results demonstrate the feasibility of the Bayesian approach on real data, and pave the way for future analysis of deep CMB polarization measurements with SPT-3G, Simons Observatory, and CMB-S4, where improvements relative to the QE can reach 1.5 times tighter constraints on $A_\phi$ and 7 times lower effective lensing reconstruction noise., Comment: 27 pages, 14 figures, accompanying software package available at https://cosmicmar.com/CMBLensing.jl
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- 2020
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18. A Demonstration of Improved Constraints on Primordial Gravitational Waves with Delensing
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BICEP/Keck, Collaborations, SPTpol, Ade, P. A. R., Ahmed, Z., Amiri, M., Anderson, A. J., Austermann, J. E., Avva, J. S., Barkats, D., Thakur, R. Basu, Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bischoff, C. A., Bleem, L. E., Bock, J. J., Boenish, H., Bullock, E., Buza, V., Carlstrom, J. E., Chang, C. L., Cheshire IV, J. R., Chiang, H. C., Chou, T-L., Citron, R., Connors, J., Moran, C. Corbett, Cornelison, J., Crawford, T. M., Crites, A. T., Crumrine, M., Cukierman, A., de Haan, T., Dierickx, M., Dobbs, M. A., Duband, L., Everett, W., Fatigoni, S., Filippini, J. P., Fliescher, S., Gallicchio, J., George, E. M., Germaine, T. St., Goeckner-Wald, N., Goldfinger, D. C., Grayson, J., Gupta, N., Hall, G., Halpern, M., Halverson, N. W., Harrison, S., Henderson, S., Henning, J. W., Hildebrandt, S. R., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Hui, H., Irwin, K. D., Kang, J., Karkare, K. S., Karpel, E., Kefeli, S., Kernasovskiy, S. A., Knox, L., Kovac, J. M., Kuo, C. L., Lau, K., Lee, A. T., Leitch, E. M., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Megerian, K. G., Meyer, S. S., Millea, M., Mocanu, L. M., Moncelsi, L., Montgomery, J., Nadolski, A., Namikawa, T., Natoli, T., Netterfield, C. B., Nguyen, H. T., Nibarger, J. P., Noble, G., Novosad, V., O'Brient, R., Ogburn IV, R. W., Omori, Y., Padin, S., Palladino, S., Patil, S., Prouve, T., Pryke, C., Racine, B., Reichardt, C. L., Reintsema, C. D., Richter, S., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Schillaci, A., Schmitt, B. L., Schwarz, R., Sheehy, C. D., Sievers, C., Smecher, G., Soliman, A., Stark, A. A., Steinbach, B., Sudiwala, R. V., Teply, G. P., Thompson, K. L., Tolan, J. E., Tucker, C., Turner, A. D., Umiltà, C., Veach, T., Vieira, J. D., Vieregg, A. G., Wandui, A., Wang, G., Weber, A. C., Whitehorn, N., Wiebe, D. V., Willmert, J., Wong, C. L., Wu, W. L. K., Yang, H., Yefremenko, V., Yoon, K. W., Young, E., Yu, C., Zeng, L., and Zhang, C.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a constraint on the tensor-to-scalar ratio, $r$, derived from measurements of cosmic microwave background (CMB) polarization $B$-modes with "delensing," whereby the uncertainty on $r$ contributed by the sample variance of the gravitational lensing $B$-modes is reduced by cross-correlating against a lensing $B$-mode template. This template is constructed by combining an estimate of the polarized CMB with a tracer of the projected large-scale structure. The large-scale-structure tracer used is a map of the cosmic infrared background derived from Planck satellite data, while the polarized CMB map comes from a combination of South Pole Telescope, BICEP/Keck, and Planck data. We expand the BICEP/Keck likelihood analysis framework to accept a lensing template and apply it to the BICEP/Keck data set collected through 2014 using the same parametric foreground modelling as in the previous analysis. From simulations, we find that the uncertainty on $r$ is reduced by $\sim10\%$, from $\sigma(r)$= 0.024 to 0.022, which can be compared with a $\sim26\%$ reduction obtained when using a perfect lensing template. Applying the technique to the real data, the constraint on $r$ is improved from $r_{0.05} < 0.090$ to $r_{0.05} < 0.082$ (95\% C.L.). This is the first demonstration of improvement in an $r$ constraint through delensing., Comment: 23 pages, 11 figures; match published version
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- 2020
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19. Searching for Anisotropic Cosmic Birefringence with Polarization Data from SPTpol
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Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Balkenhol, L., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology - Abstract
We present a search for anisotropic cosmic birefringence in 500 deg$^2$ of southern sky observed at 150 GHz with the SPTpol camera on the South Pole Telescope. We reconstruct a map of cosmic polarization rotation anisotropies using higher-order correlations between the observed cosmic microwave background (CMB) $E$ and $B$ fields. We then measure the angular power spectrum of this map, which is found to be consistent with zero. The non-detection is translated into an upper limit on the amplitude of the scale-invariant cosmic rotation power spectrum, $L(L+1)C_L^{\alpha\alpha}/2\pi < 0.10 \times 10^{-4}$ rad$^2$ (0.033 deg$^2$, 95% C.L.). This upper limit can be used to place constraints on the strength of primordial magnetic fields, $B_{1 \rm Mpc} < 17 {\rm nG} $ (95% C.L.), and on the coupling constant of the Chern-Simons electromagnetic term $g_{a\gamma} < 4.0 \times 10^{-2}/H_I $ (95% C.L.), where $H_I$ is the inflationary Hubble scale. For the first time, we also cross-correlate the CMB temperature fluctuations with the reconstructed rotation angle map, a signal expected to be non-vanishing in certain theoretical scenarios, and find no detectable signal. We perform a suite of systematics and consistency checks and find no evidence for contamination., Comment: 17 pages, 7 figures - new subsection on non-Gaussian foregrounds, conclusions unchanged - updated to match published version on PRD
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- 2020
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20. The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function
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Haykir, Betül, Moser, Seraina Olivia, Pastor-Arroyo, Eva Maria, Schnitzbauer, Udo, Radvanyi, Zsuzsa, Prucker, Isabel, Qiu, Danye, Fiedler, Dorothea, Saiardi, Adolfo, Jessen, Henning J., Hernando, Nati, and Wagner, Carsten A.
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- 2024
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21. Handbuch des Veranstaltungsrechts
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Bisges, Marcel, primary, Bahr, Henning J., additional, Bisges, Marcel, additional, Eigler, Knut, additional, Engel, Ruben, additional, Klein, Dennis, additional, Krause, Elina, additional, Lerach, Mark, additional, Mielke, Reinhard, additional, Miras, Antonio, additional, Müller, Carsten M., additional, Pahn, Boris, additional, Reitmaier, Martin, additional, and Renner, Cornelius, additional
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- 2023
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22. An Update on Polyphosphate In Vivo Activities
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Robert Schoeppe, Moritz Waldmann, Henning J. Jessen, and Thomas Renné
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polyphosphate ,energy metabolism ,exopolyphosphatase ,contact activation ,Microbiology ,QR1-502 - Abstract
Polyphosphate (polyP) is an evolutionary ancient inorganic molecule widespread in biology, exerting a broad range of biological activities. The intracellular polymer serves as an energy storage pool and phosphate/calcium ion reservoir with implications for basal cellular functions. Metabolisms of the polymer are well understood in procaryotes and unicellular eukaryotic cells. However, functions, regulation, and association with disease states of the polymer in higher eukaryotic species such as mammalians are just beginning to emerge. The review summarises our current understanding of polyP metabolism, the polymer’s functions, and methods for polyP analysis. In-depth knowledge of the pathways that control polyP turnover will open future perspectives for selective targeting of the polymer.
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- 2024
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23. An Improved Measurement of the Secondary Cosmic Microwave Background Anisotropies from the SPT-SZ + SPTpol Surveys
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Reichardt, C. L., Patil, S., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Baxter, E., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Chou, T. L., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Luong-Van, D., McMahon, J. J., Mehl, J., Meyer, S. S., Millea, M., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Sievers, C., Smecher, G., Spieler, H. G., Staniszewski, Z., Stark, A. A., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Williamson, R., Wu, W. L. K., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report new measurements of millimeter-wave power spectra in the angular multipole range $2000 \le \ell \le 11,000$ (angular scales $5^\prime \gtrsim \theta \gtrsim 1^\prime$). By adding 95 and 150\,GHz data from the low-noise 500 deg$^2$ SPTpol survey to the SPT-SZ three-frequency 2540 deg$^2$ survey, we substantially reduce the uncertainties in these bands. These power spectra include contributions from the primary cosmic microwave background, cosmic infrared background, radio galaxies, and thermal and kinematic Sunyaev-Zel'dovich (SZ) effects. The data favor a thermal SZ (tSZ) power at 143\,GHz of $D^{\rm tSZ}_{3000} = 3.42 \pm 0.54~ \mu {\rm K}^2$ and a kinematic SZ (kSZ) power of $D^{\rm kSZ}_{3000} = 3.0 \pm 1.0~ \mu {\rm K}^2$. This is the first measurement of kSZ power at $\ge 3\,\sigma$. We study the implications of the measured kSZ power for the epoch of reionization, finding the duration of reionization to be $\Delta z_{re} = 1.0^{+1.6}_{-0.7}$ ($\Delta z_{re}< 4.1$ at 95% confidence), when combined with our previously published tSZ bispectrum measurement., Comment: Submitted to ApJ, 16 pages. (revised portions of the introduction and description of bandpower estimation)
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- 2020
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24. Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
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Bennett, Ryan P., Yoluç, Yasemin, Salter, Jason D., Ripp, Alexander, Jessen, Henning J., Kaiser, Stefanie M., and Smith, Harold C.
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- 2023
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25. Broadband, millimeter-wave antireflection coatings for large-format, cryogenic aluminum oxide optics
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Nadolski, A., Vieira, J. D., Sobrin, J. A., Kofman, A. M., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Avva, J. S., Thakur, R. Basu, Bender, A. N., Benson, B. A., Bryant, L., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cheshire IV, J. R., Chesmore, G. E., Cliche, J. F., Cukierman, A., de Haan, T., Dierickx, M., Ding, J., Dutcher, D., Everett, W., Farwick, J., Ferguson, K. R., Florez, L., Foster, A., Fu, J., Gallicchio, J., Gambrel, A. E., Gardner, R. W., Groh, J. C., Guns, S., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Harris, R. J., Henning, J. W., Holzapfel, W. L., Howe, D., Huang, N., Irwin, K. D., Jeong, O., Jonas, M., Jones, A., Korman, M., Kovac, J., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Lowitz, A. E., McMahon, J., Meier, J., Meyer, S. S., Michalik, D., Montgomery, J., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Paschos, P., Pearson, J., sada, C. M. Po, Quan, W., Rahlin, A., Riebel, D., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Tandoi, C., Thompson, K. L., Tucker, C., Vanderlinde, K., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present two prescriptions for broadband (~77 - 252 GHz), millimeter-wave antireflection coatings for cryogenic, sintered polycrystalline aluminum oxide optics: one for large-format (700 mm diameter) planar and plano-convex elements, the other for densely packed arrays of quasi-optical elements, in our case 5 mm diameter half-spheres (called "lenslets"). The coatings comprise three layers of commercially-available, polytetrafluoroethylene-based, dielectric sheet material. The lenslet coating is molded to fit the 150 mm diameter arrays directly while the large-diameter lenses are coated using a tiled approach. We review the fabrication processes for both prescriptions then discuss laboratory measurements of their transmittance and reflectance. In addition, we present the inferred refractive indices and loss tangents for the coating materials and the aluminum oxide substrate. We find that at 150 GHz and 300 K the large-format coating sample achieves (97 +/- 2)% transmittance and the lenslet coating sample achieves (94 +/- 3)% transmittance., Comment: 19 pages, 11 figures; submitted 05 Dec 2019, accepted 26 Feb 2020
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- 2019
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26. Particle Physics with the Cosmic Microwave Background with SPT-3G
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Avva, J. S., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Aylor, K., Thakur, R. Basu, Bender, A. N., Benson, B. A., Bleem, L. E., Bocquet, S., Bryant, L., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Crawford, T. M., Cukierman, A., de Haan, T., Ding, J., Dobbs, M. A., Dodelson, S., Dutcher, D., Everett, W., Ferguson, K. R., Foster, A., Gallicchio, J., Gambrel, A. E., Gardner, R. W., Groh, J. C., Guns, S., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Holder, G. P., Holzapfel, W. L., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Quan, W., Raghunathan, S., Rahlin, A., Reichardt, C. L., Riebel, D., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The cosmic microwave background (CMB) encodes information about the content and evolution of the universe. The presence of light, weakly interacting particles impacts the expansion history of the early universe, which alters the temperature and polarization anisotropies of the CMB. In this way, current measurements of the CMB place interesting constraints on the neutrino energy density and mass, as well as on the abundance of other possible light relativistic particle species. We present the status of an on-going 1500 sq. deg. survey with the SPT-3G receiver, a new mm-wavelength camera on the 10-m diameter South Pole Telescope (SPT). The SPT-3G camera consists of 16,000 superconducting transition edge sensors, a 10x increase over the previous generation camera, which allows it to map the CMB with an unprecedented combination of sensitivity and angular resolution. We highlight projected constraints on the abundance of sterile neutrinos and the sum of the neutrino masses for the SPT-3G survey, which could help determine the neutrino mass hierarchy., Comment: 6 pages, 2 figures, TAUP 2019
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- 2019
27. Constraints on Cosmological Parameters from the 500 deg$^2$ SPTpol Lensing Power Spectrum
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Bianchini, F., Wu, W. L. K., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chaubal, P., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present cosmological constraints based on the cosmic microwave background (CMB) lensing potential power spectrum measurement from the recent 500 deg$^2$ SPTpol survey, the most precise CMB lensing measurement from the ground to date. We fit a flat $\Lambda$CDM model to the reconstructed lensing power spectrum alone and in addition with other data sets: baryon acoustic oscillations (BAO) as well as primary CMB spectra from Planck and SPTpol. The cosmological constraints based on SPTpol and Planck lensing band powers are in good agreement when analysed alone and in combination with Planck full-sky primary CMB data. With weak priors on the baryon density and other parameters, the CMB lensing data alone provide a 4\% constraint on $\sigma_8\Omega_m^{0.25} = 0.0593 \pm 0.025$.. Jointly fitting with BAO data, we find $\sigma_8=0.779 \pm 0.023$, $\Omega_m = 0.368^{+0.032}_{-0.037}$, and $H_0 = 72.0^{+2.1}_{-2.5}\,\text{km}\,\text{s}^{-1}\,\text{Mpc}^{-1} $, up to $2\,\sigma$ away from the central values preferred by Planck lensing + BAO. However, we recover good agreement between SPTpol and Planck when restricting the analysis to similar scales. We also consider single-parameter extensions to the flat $\Lambda$CDM model. The SPTpol lensing spectrum constrains the spatial curvature to be $\Omega_K = -0.0007 \pm 0.0025$ and the sum of the neutrino masses to be $\sum m_{\nu} < 0.23$ eV at 95\% C.L. (with Planck primary CMB and BAO data), in good agreement with the Planck lensing results. With the differences in the $S/N$ of the lensing modes and the angular scales covered in the lensing spectra, this analysis represents an important independent check on the full-sky Planck lensing measurement., Comment: 16 pages, 8 figures, 3 tables, updated to match the version published on ApJ
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28. Measurements of B-mode Polarization of the Cosmic Microwave Background from 500 Square Degrees of SPTpol Data
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Sayre, J. T., Reichardt, C. L., Henning, J. W., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., McMahon, J. J., Meyer, S. S., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Padin, S., Patil, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Schaffer, K. K., Sievers, C., Smecher, G., Stark, A. A., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report a B-mode power spectrum measurement from the cosmic microwave background (CMB) polarization anisotropy observations made using the SPTpol instrument on the South Pole Telescope. This work uses 500 deg$^2$ of SPTpol data, a five-fold increase over the last SPTpol B-mode release. As a result, the bandpower uncertainties have been reduced by more than a factor of two, and the measurement extends to lower multipoles: $52 < \ell < 2301$. Data from both 95 and 150 GHz are used, allowing for three cross-spectra: 95 GHz x 95 GHz, 95 GHz x 150 GHz, and 150 GHz x 150 GHz. B-mode power is detected at very high significance; we find $P(BB < 0) = 5.8 \times 10^{-71}$, corresponding to a $18.1 \sigma$ detection of power. An upper limit is set on the tensor-to-scalar ratio, $r < 0.44$ at 95% confidence (the expected $1 \sigma$ constraint on $r$ given the measurement uncertainties is 0.22). We find the measured B-mode power is consistent with the Planck best-fit $\Lambda$CDM model predictions. Scaling the predicted lensing B-mode power in this model by a factor Alens, the data prefer Alens = $1.17 \pm 0.13$. These data are currently the most precise measurements of B-mode power at $\ell > 320$., Comment: 16 pages, 4 figures, Submitted to PRD
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29. The SPTpol Extended Cluster Survey
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Bleem, L. E., Bocquet, S., Stalder, B., Gladders, M. D., Ade, P. A. R., Allen, S. W., Anderson, A. J., Annis, J., Ashby, M. L. N., Austermann, J. E., Avila, S., Avva, J. S., Bayliss, M., Beall, J. A., Bechtol, K., Bender, A. N., Benson, B. A., Bertin, E., Bianchini, F., Blake, C., Brodwin, M., Brooks, D., Buckley-Geer, E., Burke, D. L., Carlstrom, J. E., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Chang, C. L., Chiang, H. C., Citron, R., Moran, C. Corbett, Costanzi, M., Crawford, T. M., Crites, A. T., da Costa, L. N., de Haan, T., De Vicente, J., Desai, S., Diehl, H. T., Dietrich, J. P., Dobbs, M. A., Eifler, T. F., Everett, W., Flaugher, B., Floyd, B., Frieman, J., Gallicchio, J., García-Bellido, J., George, E. M., Gerdes, D. W., Gilbert, A., Gruen, D., Gruendl, R. A., Gschwend, J., Gupta, N., Gutierrez, G., Halverson, N. W., Harrington, N., Henning, J. W., Heymans, C., Holder, G. P., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., James, D. J., Jeltema, T., Joudaki, S., Khullar, G., Klein, M., Knox, L., Kuropatkin, N., Lee, A. T., Li, D., Lidman, C., Lowitz, A., MacCrann, N., Mahler, G., Maia, M. A. G., Marshall, J. L., McDonald, M., McMahon, J. J., Melchior, P., Menanteau, F., Meyer, S. S., Miquel, R., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Padin, S., Palmese, A., Parkinson, D., Patil, S., Paz-Chinchón, F., Plazas, A. A., Pryke, C., Ramachandra, N. S., Reichardt, C. L., González, J. D. Remolina, Romer, A. K., Roodman, A., Ruhl, J. E., Rykoff, E. S., Saliwanchik, B. R., Sanchez, E., Saro, A., Sayre, J. T., Schaffer, K. K., Schrabback, T., Serrano, S., Sharon, K., Sievers, C., Smecher, G., Smith, M., Soares-Santos, M., Stark, A. A., Story, K. T., Suchyta, E., Tarle, G., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Weller, J., Whitehorn, N., Wu, W. L. K., Yefremenko, V., and Zhang, Y.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We describe the observations and resultant galaxy cluster catalog from the 2770 deg$^2$ SPTpol Extended Cluster Survey (SPT-ECS). Clusters are identified via the Sunyaev-Zel'dovich (SZ) effect, and confirmed with a combination of archival and targeted follow-up data, making particular use of data from the Dark Energy Survey (DES). With incomplete followup we have confirmed as clusters 244 of 266 candidates at a detection significance $\xi \ge 5$ and an additional 204 systems at $4<\xi<5$. The confirmed sample has a median mass of $M_{500c} \sim {4.4 \times 10^{14} M_\odot h_{70}^{-1}}$, a median redshift of $z=0.49$, and we have identified 44 strong gravitational lenses in the sample thus far. Radio data are used to characterize contamination to the SZ signal; the median contamination for confirmed clusters is predicted to be $\sim$1% of the SZ signal at the $\xi>4$ threshold, and $<4\%$ of clusters have a predicted contamination $>10\% $ of their measured SZ flux. We associate SZ-selected clusters, from both SPT-ECS and the SPT-SZ survey, with clusters from the DES redMaPPer sample, and find an offset distribution between the SZ center and central galaxy in general agreement with previous work, though with a larger fraction of clusters with significant offsets. Adopting a fixed Planck-like cosmology, we measure the optical richness-to-SZ-mass ($\lambda-M$) relation and find it to be 28% shallower than that from a weak-lensing analysis of the DES data---a difference significant at the 4 $\sigma$ level---with the relations intersecting at $\lambda=60$ . The SPT-ECS cluster sample will be particularly useful for studying the evolution of massive clusters and, in combination with DES lensing observations and the SPT-SZ cluster sample, will be an important component of future cosmological analyses., Comment: 49 pages, 14 figures, 10 tables. Minor changes to match accepted version in ApJS
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30. Performance of Al-Mn Transition-Edge Sensor Bolometers in SPT-3G
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Anderson, A. J., Ade, P. A. R., Ahmed, Z., Avva, J. S., Barry, P. S., Thakur, R. Basu, Bender, A. N., Benson, B. A., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cho, H. -M., Cliche, J. F., Cukierman, A., de Haan, T., Denison, E. V., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Ferguson, K. R., Foster, A., Fu, J., Gallicchio, J., Gambrel, A. E., Gardner, R. W., Gilbert, A., Groh, J. C., Guns, S., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Holzapfel, W. L., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Quan, W., Rahlin, A., Riebel, D., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
SPT-3G is a polarization-sensitive receiver, installed on the South Pole Telescope, that measures the anisotropy of the cosmic microwave background (CMB) from degree to arcminute scales. The receiver consists of ten 150~mm-diameter detector wafers, containing a total of 16,000 transition-edge sensor (TES) bolometers observing at 95, 150, and 220 GHz. During the 2018-2019 austral summer, one of these detector wafers was replaced by a new wafer fabricated with Al-Mn TESs instead of the Ti/Au design originally deployed for SPT-3G. We present the results of in-lab characterization and on-sky performance of this Al-Mn wafer, including electrical and thermal properties, optical efficiency measurements, and noise-equivalent temperature. In addition, we discuss and account for several calibration-related systematic errors that affect measurements made using frequency-domain multiplexing readout electronics., Comment: 9 pages, 5 figures, submitted to the Journal of Low Temperature Physics: LTD18 Special Edition
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31. On-sky performance of the SPT-3G frequency-domain multiplexed readout
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Bender, A. N., Anderson, A. J., Avva, J. S., Ade, P. A. R., Ahmed, Z., Barry, P. S., Thakur, R. Basu, Benson, B. A., Bryant, L., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cho, H. -M., Cliche, J. F., Cukierman, A., de Haan, T., Denison, E. V., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Ferguson, K. R., Foster, A., Fu, J., Gallicchio, J., Gambrel, A. E., Gardner, R. W., Gilbert, A., Groh, J. C., Guns, S., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Holzapfel, W. L., Howe, D., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Paschos, P., Pearson, J., Posada, C. M., Quan, W., Rahlin, A., Riebel, D., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Stephen, J., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
Frequency-domain multiplexing (fMux) is an established technique for the readout of large arrays of transition edge sensor (TES) bolometers. Each TES in a multiplexing module has a unique AC voltage bias that is selected by a resonant filter. This scheme enables the operation and readout of multiple bolometers on a single pair of wires, reducing thermal loading onto sub-Kelvin stages. The current receiver on the South Pole Telescope, SPT-3G, uses a 68x fMux system to operate its large-format camera of $\sim$16,000 TES bolometers. We present here the successful implementation and performance of the SPT-3G readout as measured on-sky. Characterization of the noise reveals a median pair-differenced 1/f knee frequency of 33 mHz, indicating that low-frequency noise in the readout will not limit SPT-3G's measurements of sky power on large angular scales. Measurements also show that the median readout white noise level in each of the SPT-3G observing bands is below the expectation for photon noise, demonstrating that SPT-3G is operating in the photon-noise-dominated regime., Comment: 9 pages, 5 figures submitted to the Journal of Low Temperature Physics: LTD18 Special Edition
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32. Galaxy Clusters Selected via the Sunyaev-Zel'dovich Effect in the SPTpol 100-Square-Degree Survey
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Huang, N., Bleem, L. E., Stalder, B., Ade, P. A. R., Allen, S. W., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bocquet, S., Brodwin, M., Carlstrom, J. E., Chang, C. L., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Floyd, B., Gallicchio, J., George, E. M., Gilbert, A., Gladders, M. D., Guns, S., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hrubes, J. D., Hubmayr, J., Irwin, K. D., Khullar, G., Knox, L., Lee, A. T., Li, D., Lowitz, A., McDonald, M., McMahon, J. J., Meyer, S. S., Mocanu, L. M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Saro, A., Sayre, J. T., Schaffer, K. K., Sharon, K., Sievers, C., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a catalog of galaxy cluster candidates detected in 100 square degrees surveyed with the SPTpol receiver on the South Pole Telescope. The catalog contains 89 candidates detected with a signal-to-noise ratio greater than 4.6. The candidates are selected using the Sunyaev-Zel'dovich effect at 95 and 150 GHz. Using both space- and ground-based optical and infrared telescopes, we have confirmed 81 candidates as galaxy clusters. We use these follow-up images and archival images to estimate photometric redshifts for 66 galaxy clusters and spectroscopic observations to obtain redshifts for 13 systems. An additional 2 galaxy clusters are confirmed using the overdensity of near-infrared galaxies only, and are presented without redshifts. We find that 15 candidates (18% of the total sample) are at redshift of $z \geq 1.0$, with a maximum confirmed redshift of $z_{\rm{max}} = 1.38 \pm 0.10$. We expect this catalog to contain every galaxy cluster with $M_{500c} > 2.6 \times 10^{14} M_\odot h^{-1}_{70}$ and $z > 0.25$ in the survey area. The mass threshold is approximately constant above $z = 0.25$, and the complete catalog has a median mass of approximately $ M_{500c} = 2.7 \times 10^{14} M_\odot h^{-1}_{70}$. Compared to previous SPT works, the increased depth of the millimeter-wave data (11.2 and 6.5 $\mu$K-arcmin at 95 and 150 GHz, respectively) makes it possible to find more galaxy clusters at high redshift and lower mass., Comment: 21 pages, 7 figures, associated data available at http://pole.uchicago.edu/public/data/sptsz-clusters. V2 was accepted to the AJ, and includes minor changes requested by the reviewer
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33. A Detection of CMB-Cluster Lensing using Polarization Data from SPTpol
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Raghunathan, S., Patil, S., Baxter, E., Benson, B. A., Bleem, L. E., Crawford, T. M., Holder, G. P., McClintock, T., Reichardt, C. L., Varga, T. N., Whitehorn, N., Ade, P. A. R., Allam, S., Anderson, A. J., Austermann, J. E., Avila, S., Avva, J. S., Bacon, D., Beall, J. A., Bender, A. N., Bianchini, F., Bocquet, S., Brooks, D., Burke, D. L., Carlstrom, J. E., Carretero, J., Castander, F. J., Chang, C. L., Chiang, H. C., Citron, R., Costanzi, M., Crites, A. T., da Costa, L. N., Desai, S., Diehl, H. T., Dietrich, J. P., Dobbs, M. A., Doel, P., Everett, S., Evrard, A. E., Feng, C., Flaugher, B., Fosalba, P., Frieman, J., Gallicchio, J., García-Bellido, J., Gaztanaga, E., George, E. M., Giannantonio, T., Gilbert, A., Gruendl, R. A., Gschwend, J., Gupta, N., Gutierrez, G., de Haan, T., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Jeltema, T., Kind, M. Carrasco, Knox, L., Kuropatkin, N., Lahav, O., Lee, A. T., Li, D., Lima, M., Lowitz, A., Maia, M. A. G., Marshall, J. L., McMahon, J. J., Melchior, P., Menanteau, F., Meyer, S. S., Miquel, R., Mocanu, L. M., Mohr, J. J., Montgomery, J., Moran, C. Corbett, Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G., Novosad, V., Ogando, R. L. C., Padin, S., Plazas, A. A., Pryke, C., Rapetti, D., Romer, A. K., Roodman, A., Rosell, A. Carnero, Rozo, E., Ruhl, J. E., Rykoff, E. S., Saliwanchik, B. R., Sanchez, E., Sayre, J. T., Scarpine, V., Schaffer, K. K., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Sievers, C., Smecher, G., Smith, M., Soares-Santos, M., Stark, A. A., Story, K. T., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, C., Vanderlinde, K., Veach, T., De Vicente, J., Vieira, J. D., Vikram, V., Wang, G., Wu, W. L. K., Yefremenko, V., and Zhang, Y.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report the first detection of gravitational lensing due to galaxy clusters using only the polarization of the cosmic microwave background (CMB). The lensing signal is obtained using a new estimator that extracts the lensing dipole signature from stacked images formed by rotating the cluster-centered Stokes $Q/U$ map cutouts along the direction of the locally measured background CMB polarization gradient. Using data from the SPTpol 500 deg$^{2}$ survey at the locations of roughly 18,000 clusters with richness $\lambda \ge 10$ from the Dark Energy Survey (DES) Year-3 full galaxy cluster catalog, we detect lensing at $4.8\sigma$. The mean stacked mass of the selected sample is found to be $(1.43 \pm 0.4)\ \times 10^{14}\ {\rm M_{\odot}}$ which is in good agreement with optical weak lensing based estimates using DES data and CMB-lensing based estimates using SPTpol temperature data. This measurement is a key first step for cluster cosmology with future low-noise CMB surveys, like CMB-S4, for which CMB polarization will be the primary channel for cluster lensing measurements., Comment: 10 pages, 3 figures, 1 table; typos fixed; accepted for publication in PRL
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- 2019
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34. Fractional Polarisation of Extragalactic Sources in the 500-square-degree SPTpol Survey
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Gupta, N., Reichardt, C. L., Ade, P. A. R., Anderson, A. J., Archipley, M., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Feng, C., Gallicchio, J., George, E. M., Gilbert, A., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hou, Z., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Luong-Van, D., Marrone, D. P., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Mocanu, L. M., Mohr, J. J., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Sievers, C., Smecher, G., Staniszewski, Z., Stark, A. A., Story, K. T., Switzer, E. R., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., Williamson, R., Wu, W. L. K., Yefremenko, V., and Zhang, L.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We study the polarisation properties of extragalactic sources at 95 and 150 GHz in the SPTpol 500 deg$^2$ survey. We estimate the polarised power by stacking maps at known source positions, and correct for noise bias by subtracting the mean polarised power at random positions in the maps. We show that the method is unbiased using a set of simulated maps with similar noise properties to the real SPTpol maps. We find a flux-weighted mean-squared polarisation fraction $\langle p^2 \rangle= [8.9\pm1.1] \times 10^{-4}$ at 95 GHz and $[6.9\pm1.1] \times 10^{-4}$ at 150~GHz for the full sample. This is consistent with the values obtained for a sub-sample of active galactic nuclei. For dusty sources, we find 95 per cent upper limits of $\langle p^2 \rangle_{\rm 95}<16.9 \times 10^{-3}$ and $\langle p^2 \rangle_{\rm 150}<2.6 \times 10^{-3}$. We find no evidence that the polarisation fraction depends on the source flux or observing frequency. The 1-$\sigma$ upper limit on measured mean squared polarisation fraction at 150 GHz implies that extragalactic foregrounds will be subdominant to the CMB E and B mode polarisation power spectra out to at least $\ell\lesssim5700$ ($\ell\lesssim4700$) and $\ell\lesssim5300$ ($\ell\lesssim3600$), respectively at 95 (150) GHz., Comment: 10 pages, 5 figures
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- 2019
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35. A Measurement of the Cosmic Microwave Background Lensing Potential and Power Spectrum from 500 deg$^2$ of SPTpol Temperature and Polarization Data
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Wu, W. L. K., Mocanu, L. M., Ade, P. A. R., Anderson, A. J., Austermann, J. E., Avva, J. S., Beall, J. A., Bender, A. N., Benson, B. A., Bianchini, F., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Chiang, H. C., Citron, R., Moran, C. Corbett, Crawford, T. M., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W., Gallicchio, J., George, E. M., Gilbert, A., Gupta, N., Halverson, N. W., Harrington, N., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Hou, Z., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., Knox, L., Lee, A. T., Li, D., Lowitz, A., Manzotti, A., McMahon, J. J., Meyer, S. S., Millea, M., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Noble, G. I., Novosad, V., Omori, Y., Padin, S., Patil, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Saliwanchik, B. R., Sayre, J. T., Schaffer, K. K., Sievers, C., Simard, G., Smecher, G., Stark, A. A., Story, K. T., Tucker, C., Vanderlinde, K., Veach, T., Vieira, J. D., Wang, G., Whitehorn, N., and Yefremenko, V.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a measurement of the cosmic microwave background (CMB) lensing potential using 500 deg$^2$ of 150 GHz data from the SPTpol receiver on the South Pole Telescope. The lensing potential is reconstructed with signal-to-noise per mode greater than unity at lensing multipoles $L \lesssim 250$, using a quadratic estimator on a combination of CMB temperature and polarization maps. We report measurements of the lensing potential power spectrum in the multipole range of $100< L < 2000$ from sets of temperature-only, polarization-only, and minimum-variance estimators. We measure the lensing amplitude by taking the ratio of the measured spectrum to the expected spectrum from the best-fit $\Lambda$CDM model to the $\textit{Planck}$ 2015 TT+lowP+lensing dataset. For the minimum-variance estimator, we find $A_{\rm{MV}} = 0.944 \pm 0.058{\rm (Stat.)}\pm0.025{\rm (Sys.)}$; restricting to only polarization data, we find $A_{\rm{POL}} = 0.906 \pm 0.090 {\rm (Stat.)} \pm 0.040 {\rm (Sys.)}$. Considering statistical uncertainties alone, this is the most precise polarization-only lensing amplitude constraint to date (10.1 $\sigma$), and is more precise than our temperature-only constraint. We perform null tests and consistency checks and find no evidence for significant contamination., Comment: 18 pages, 8 figures; updated to match published version
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- 2019
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36. Consistency of cosmic microwave background temperature measurements in three frequency bands in the 2500-square-degree SPT-SZ survey
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Mocanu, L. M., Crawford, T. M., Aylor, K., Benson, B. A., Bleem, L. E., Carlstrom, J. E., Chang, C. L., Cho, H-M., Chown, R., Crites, A. T., de Haan, T., Dobbs, M. A., Everett, W. B., George, E. M., Halverson, N. W., Harrington, N. L., Henning, J. W., Holder, G. P., Holzapfel, W. L., Hou, Z., Hrubes, J. D., Knox, L., Lee, A. T., Luong-Van, D., Marrone, D. P., McMahon, J. J., Meyer, S. S., Millea, M., Mohr, J. J., Natoli, T., Omori, Y., Padin, S., Pryke, C., Reichardt, C. L., Ruhl, J. E., Sayre, J. T., Schaffer, K. K., Shirokoff, E., Staniszewski, Z., Stark, A. A., Story, K. T., Vanderlinde, K., Vieira, J. D., Williamson, R., and Wu, W. L. K.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present an internal consistency test of South Pole Telescope (SPT) measurements of the cosmic microwave background (CMB) temperature anisotropy using three-band data from the SPT-SZ survey. These measurements are made from observations of ~2500 deg^2 of sky in three frequency bands centered at 95, 150, and 220 GHz. We combine the information from these three bands into six semi-independent estimates of the CMB power spectrum (three single-frequency power spectra and three cross-frequency spectra) over the multipole range 650 < l < 3000. We subtract an estimate of foreground power from each power spectrum and evaluate the consistency among the resulting CMB-only spectra. We determine that the six foreground-cleaned power spectra are consistent with the null hypothesis, in which the six cleaned spectra contain only CMB power and noise. A fit of the data to this model results in a chi-squared value of 236.3 for 235 degrees of freedom, and the probability to exceed this chi-squared value is 46%., Comment: 21 pages, 4 figures, current version matches version published in JCAP
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- 2019
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37. H2O2 selectively damages the binuclear iron-sulfur cluster N1b of respiratory complex I
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Strotmann, Lisa, Harter, Caroline, Gerasimova, Tatjana, Ritter, Kevin, Jessen, Henning J., Wohlwend, Daniel, and Friedrich, Thorsten
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- 2023
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38. Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase
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Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, and Stewart Shuman
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inositol pyrophosphates ,inorganic polyphosphate ,pyrophosphatase ,Schizosaccharomyces pombe ,transcription termination ,Microbiology ,QR1-502 - Abstract
ABSTRACT Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,5-IP8 and two pyrophosphatases—the Asp1 pyrophosphatase domain (histidine acid phosphatase family) and the Aps1 pyrophosphatase enzyme (Nudix family)—that hydrolyze the β-phosphates of 1,5-IP8. Here, we characterize S. pombe Siw14 (SpSiw14), a cysteinyl-phosphatase family member and a homolog of Saccharomyces cerevisiae Siw14, as a third fission yeast pyrophosphatase implicated in inositol pyrophosphate catabolism. We find that SpSiw14’s substrate repertoire embraces inorganic pyrophosphate, inorganic polyphosphate, and the inositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8, in addition to the generic substrate p-nitrophenylphosphate. Genetic analyses revealed that (i) elimination of the SpSiw14 protein or inactivation of the SpSiw14 pyrophosphatase by the C189S mutation had no effect on S. pombe growth but was lethal in the absence of Aps1 and (ii) the synthetic lethality of siw14∆ aps1∆ depended on the synthesis of 1,5-IP8 by the Asp1 kinase. We conclude that SpSiw14 and Aps1 pyrophosphatases have essential but redundant functions in fission yeast, and that their synthetic lethality is a consequence of the toxic effects of too much 1,5-IP8. Suppression of siw14∆ aps1∆ lethality by loss-of-function mutations of components of the fission yeast 3′-processing/termination machinery fortifies the case for overzealous transcription termination as the basis for 1,5-IP8 toxicosis. IMPORTANCE The inositol pyrophosphate signaling molecule 1,5-IP8 modulates fission yeast phosphate homeostasis via its action as an agonist of RNA 3′-processing and transcription termination. Cellular 1,5-IP8 levels are determined by a balance between the activities of the inositol polyphosphate kinase Asp1 and several inositol pyrophosphatase enzymes. Here, we characterize Schizosaccharomyces pombe Siw14 (SpSiw14) as a cysteinyl-phosphatase-family pyrophosphatase enzyme capable of hydrolyzing the phosphoanhydride substrates inorganic pyrophosphate, inorganic polyphosphate, and inositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8. Genetic analyses implicate SpSiw14 in 1,5-IP8 catabolism in vivo, insofar as: loss of SpSiw14 activity is lethal in the absence of the Nudix-type inositol pyrophosphatase enzyme Aps1; and siw14∆ aps1∆ lethality depends on synthesis of 1,5-IP8 by the Asp1 kinase. Suppression of siw14∆ aps1∆ lethality by loss-of-function mutations of 3′-processing/termination factors points to precocious transcription termination as the cause of 1,5-IP8 toxicosis.
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- 2023
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39. Design and Bolometer Characterization of the SPT-3G First-year Focal Plane
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Everett, W., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Austermann, J. E., Avva, J. S., Thakur, R. Basu, Bender, A. N., Benson, B. A., Carlstrom, J. E., Carter, F. W., Cecil, T., Chang, C. L., Cliche, J. F., Cukierman, A., Denison, E. V., de Haan, T., Ding, J., Dobbs, M. A., Dutcher, D., Foster, A., Gannon, R. N., Gilbert, A., Groh, J. C., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Holzapfel, W. L., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Khaire, T., Kofman, A. M., Korman, M., Kubik, D., Kuhlmann, S., Kuo, C. L., Lee, A. T., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Pearson, J., Posada, C. M., Rahlin, A., Ruhl, J. E., Saunders, L. J., Sayre, J. T., Shirley, I., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Story, K. T., Suzuki, A., Tang, Q. Y., Thompson, K. L., Tucker, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
During the austral summer of 2016-17, the third-generation camera, SPT-3G, was installed on the South Pole Telescope, increasing the detector count in the focal plane by an order of magnitude relative to the previous generation. Designed to map the polarization of the cosmic microwave background, SPT-3G contains ten 6-in-hexagonal modules of detectors, each with 269 trichroic and dual-polarization pixels, read out using 68x frequency-domain multiplexing. Here we discuss design, assembly, and layout of the modules, as well as early performance characterization of the first-year array, including yield and detector properties., Comment: Conference proceeding for Low Temperature Detectors 2017. Accepted for publication: 27 August 2018
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- 2019
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40. Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system
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Ito, Masatoshi, Fujii, Natsuko, Kohara, Saori, Hori, Shuho, Tanaka, Masayuki, Wittwer, Christopher, Kikuchi, Kenta, Iijima, Takatoshi, Kakimoto, Yu, Hirabayashi, Kenichi, Kurotaki, Daisuke, Jessen, Henning J., Saiardi, Adolfo, and Nagata, Eiichiro
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- 2023
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41. Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
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Qin, Ning, Li, Lingyun, Ji, Xu, Pereira, Rui, Chen, Yu, Yin, Shile, Li, Chaokun, Wan, Xiaozhen, Qiu, Danye, Jiang, Junfeng, Luo, Hao, Zhang, Yueping, Dong, Genlai, Zhang, Yiming, Shi, Shuobo, Jessen, Henning J., Xia, Jianye, Chen, Yun, Larsson, Christer, Tan, Tianwei, Liu, Zihe, and Nielsen, Jens
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- 2023
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42. Mass Calibration of Optically Selected DES clusters using a Measurement of CMB-Cluster Lensing with SPTpol Data
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Raghunathan, S., Patil, S., Baxter, E., Benson, B. A., Bleem, L. E., Chou, T. L., Crawford, T. M., Holder, G. P., McClintock, T., Reichardt, C. L., Rozo, E., Varga, T. N., Abbott, T. M. C., Ade, P. A. R., Allam, S., Anderson, A. J., Annis, J., Austermann, J. E., Avila, S., Beall, J. A., Bechtol, K., Bender, A. N., Bernstein, G., Bertin, E., Bianchini, F., Bleem, L., Brooks, D., Burke, D. L., Carlstrom, J. E., Carretero, J., Chang, C. L., Chiang, H. C., Cho, H-M., Citron, R., Crites, A. T., Cunha, C. E., da Costa, L. N., Davis, C., Desai, S., Diehl, H. T., Dietrich, J. P., Dobbs, M. A., Doel, P., Eifler, T. F., Everett, W., Evrard, A. E., Flaugher, B., Fosalba, P., Frieman, J., Gallicchio, J., García-Bellido, J., Gaztanaga, E., George, E. M., Gilbert, A., Gruendl, R. A., Gruen, D., Gschwend, J., Gupta, N., Gutierrez, G., de Haan, T., Halverson, N. W., Harrington, N., Hartley, W. G., Henning, J. W., Hilton, G. C., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hou, Z., Hoyle, B., Hrubes, J. D., Huang, N., Hubmayr, J., Irwin, K. D., James, D. J., Jeltema, T., Kim, A. G., Kind, M. Carrasco, Knox, L., Kovacs, A., Kuehn, K., Kuropatkin, N., Lee, A. T., Lima, M., Li, T. S., Maia, M. A. G., Marshall, J. L., McMahon, J. J., Melchior, P., Menanteau, F., Meyer, S. S., Miller, C. J., Miquel, R., Mocanu, L., Montgomery, J., Nadolski, A., Natoli, T., Nibarger, J. P., Novosad, V., Padin, S., Plazas, A. A., Pryke, C., Rapetti, D., Romer, A. K., Rosell, A. Carnero, Ruhl, J. E., Saliwanchik, B. R., Sanchez, E., Sayre, J. T., Scarpine, V., Schaffer, K. K., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Smecher, G., Smith, R. C., Soares-Santos, M., Sobreira, F., Stark, A. A., Story, K. T., Suchyta, E., Swanson, M. E. C., Tarle, G., Thomas, D., Tucker, C., Vanderlinde, K., De Vicente, J., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., and Zhang, Y.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We use cosmic microwave background (CMB) temperature maps from the 500 deg$^{2}$ SPTpol survey to measure the stacked lensing convergence of galaxy clusters from the Dark Energy Survey (DES) Year-3 redMaPPer (RM) cluster catalog. The lensing signal is extracted through a modified quadratic estimator designed to be unbiased by the thermal Sunyaev-Zel{'}dovich (tSZ) effect. The modified estimator uses a tSZ-free map, constructed from the SPTpol 95 and 150 GHz datasets, to estimate the background CMB gradient. For lensing reconstruction, we employ two versions of the RM catalog: a flux-limited sample containing 4003 clusters and a volume-limited sample with 1741 clusters. We detect lensing at a significance of 8.7$\sigma$(6.7$\sigma$) with the flux(volume)-limited sample. By modeling the reconstructed convergence using the Navarro-Frenk-White profile, we find the average lensing masses to be $M_{200m}$ = ($1.62^{+0.32}_{-0.25}$ [stat.] $\pm$ 0.04 [sys.]) and ($1.28^{+0.14}_{-0.18}$ [stat.] $\pm$ 0.03 [sys.]) $\times\ 10^{14}\ M_{\odot}$ for the volume- and flux-limited samples respectively. The systematic error budget is much smaller than the statistical uncertainty and is dominated by the uncertainties in the RM cluster centroids. We use the volume-limited sample to calibrate the normalization of the mass-richness scaling relation, and find a result consistent with the galaxy weak-lensing measurements from DES (Mcclintock et al. 2018)., Comment: 19 pages, 6 figures, published in ApJ
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- 2018
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43. Year two instrument status of the SPT-3G cosmic microwave background receiver
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Bender, A. N., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Avva, J. S., Aylor, K., Barry, P. S., Thakur, R. Basu, Benson, B. A., Bleem, L. S., Bocquet, S., Byrum, K., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cho, H. -M., Cliche, J. F., Crawford, T. M., Cukierman, A., de Haan, T., Denison, E. V., Ding, J., Dobbs, M. A., Dodelson, S., Dutcher, D., Everett, W., Foster, A., Gallicchio, J., Gilbert, A., Groh, J. C., Guns, S. T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Hilton, G. C., Holder, G. P., Holzapfel, W. L., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Knox, L., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Leitch, E. M., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Pearson, J., Posada, C. M., Quan, W., Raghunathan, S., Rahlin, A., Reichardt, C. L., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vale, L. R., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Wu, W. L. K., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Experiment - Abstract
The South Pole Telescope (SPT) is a millimeter-wavelength telescope designed for high-precision measurements of the cosmic microwave background (CMB). The SPT measures both the temperature and polarization of the CMB with a large aperture, resulting in high resolution maps sensitive to signals across a wide range of angular scales on the sky. With these data, the SPT has the potential to make a broad range of cosmological measurements. These include constraining the effect of massive neutrinos on large-scale structure formation as well as cleaning galactic and cosmological foregrounds from CMB polarization data in future searches for inflationary gravitational waves. The SPT began observing in January 2017 with a new receiver (SPT-3G) containing $\sim$16,000 polarization-sensitive transition-edge sensor bolometers. Several key technology developments have enabled this large-format focal plane, including advances in detectors, readout electronics, and large millimeter-wavelength optics. We discuss the implementation of these technologies in the SPT-3G receiver as well as the challenges they presented. In late 2017 the implementations of all three of these technologies were modified to optimize total performance. Here, we present the current instrument status of the SPT-3G receiver., Comment: 21 pages, 9 Figures, Presented at SPIE Astronomical Telescopes + Instrumentation 2018
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- 2018
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44. Characterization and performance of the second-year SPT-3G focal plane
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Dutcher, D., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Avva, J. S., Thakur, R. Basu, Bender, A. N., Benson, B. A., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cliche, J. F., Cukierman, A., de Haan, T., Ding, J., Dobbs, M. A., Everett, W., Foster, A., Gallicchio, J., Gilbert, A., Groh, J. C., Guns, S. T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Holzapfel, W. L., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Khaire, T. S., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Pearson, J., Posada, C. M., Quan, W., Rahlin, A., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M. R.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The third-generation instrument for the 10-meter South Pole Telescope, SPT-3G, was first installed in January 2017. In addition to completely new cryostats, secondary telescope optics, and readout electronics, the number of detectors in the focal plane has increased by an order of magnitude from previous instruments to ~16,000. The SPT-3G focal plane consists of ten detector modules, each with an array of 269 trichroic, polarization-sensitive pixels on a six-inch silicon wafer. Within each pixel is a broadband, dual-polarization sinuous antenna; the signal from each orthogonal linear polarization is divided into three frequency bands centered at 95, 150, and 220 GHz by in-line lumped element filters and transmitted via superconducting microstrip to Ti/Au transition-edge sensor (TES) bolometers. Properties of the TES film, microstrip filters, and bolometer island must be tightly controlled to achieve optimal performance. For the second year of SPT-3G operation, we have replaced all ten wafers in the focal plane with new detector arrays tuned to increase mapping speed and improve overall performance. Here we discuss the TES superconducting transition temperature and normal resistance, detector saturation power, bandpasses, optical efficiency, and full array yield for the 2018 focal plane., Comment: 13 pages, 11 figures
- Published
- 2018
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45. Design and characterization of the SPT-3G receiver
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Sobrin, J. A., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Avva, J. S., Thakur, R. Basu, Bender, A. N., Benson, B. A., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cliche, J. F., Cukierman, A., de Haan, T., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Foster, A., Gallichio, J., Gilbert, A., Groh, J. C., Guns, S. T., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Holzapfel, W. L., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Khaire, T. S., Kofman, A. M., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. L., Lee, A. T., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Nadolski, A., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Pearson, J., Posada, C. M., Quan, W., Rahlin, A., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Stark, A. A., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vanderlinde, K., Vieira, J. D., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The SPT-3G receiver was commissioned in early 2017 on the 10-meter South Pole Telescope (SPT) to map anisotropies in the cosmic microwave background (CMB). New optics, detector, and readout technologies have yielded a multichroic, high-resolution, low-noise camera with impressive throughput and sensitivity, offering the potential to improve our understanding of inflationary physics, astroparticle physics, and growth of structure. We highlight several key features and design principles of the new receiver, and summarize its performance to date., Comment: Conference Presentation at SPIE Astronomical Telescopes + Instrumentation 2018, conference 10708
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- 2018
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46. Broadband anti-reflective coatings for cosmic microwave background experiments
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Nadolski, A., Kofman, A. M., Vieira, J. D., Ade, P. A. R., Ahmed, Z., Anderson, A. J., Avva, J. S., Thakur, R. Basu, Bender, A. N., Benson, B. A., Carlstrom, J. E., Carter, F. W., Cecil, T. W., Chang, C. L., Cliche, J. F., Cukierman, A., de Haan, T., Ding, J., Dobbs, M. A., Dutcher, D., Everett, W., Foster, A., Fu, J., Gallicchio, J., Gilbert, A., Groh, J. C., Guns, S. T., Guyser, R., Halverson, N. W., Harke-Hosemann, A. H., Harrington, N. L., Henning, J. W., Holzapfel, W. L., Huang, N., Irwin, K. D., Jeong, O. B., Jonas, M., Jones, A., Khaire, T. S., Korman, M., Kubik, D. L., Kuhlmann, S., Kuo, C. -L., Lee, A. T., Lowitz, A. E., Meyer, S. S., Michalik, D., Montgomery, J., Natoli, T., Nguyen, H., Noble, G. I., Novosad, V., Padin, S., Pan, Z., Pearson, J., Posada, C. M., Quan, W., Rahlin, A., Ruhl, J. E., Sayre, J. T., Shirokoff, E., Smecher, G., Sobrin, J. A., Stark, A. A., Story, K. T., Suzuki, A., Thompson, K. L., Tucker, C., Vanderlinde, K., Wang, G., Whitehorn, N., Yefremenko, V., Yoon, K. W., and Young, M. R.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The desire for higher sensitivity has driven ground-based cosmic microwave background (CMB) experiments to employ ever larger focal planes, which in turn require larger reimaging optics. Practical limits to the maximum size of these optics motivates the development of quasi-optically-coupled (lenslet-coupled), multi-chroic detectors. These detectors can be sensitive across a broader bandwidth compared to waveguide-coupled detectors. However, the increase in bandwidth comes at a cost: the lenses (up to $\sim$700 mm diameter) and lenslets ($\sim$5 mm diameter, hemispherical lenses on the focal plane) used in these systems are made from high-refractive-index materials (such as silicon or amorphous aluminum oxide) that reflect nearly a third of the incident radiation. In order to maximize the faint CMB signal that reaches the detectors, the lenses and lenslets must be coated with an anti-reflective (AR) material. The AR coating must maximize radiation transmission in scientifically interesting bands and be cryogenically stable. Such a coating was developed for the third generation camera, SPT-3G, of the South Pole Telescope (SPT) experiment, but the materials and techniques used in the development are general to AR coatings for mm-wave optics. The three-layer polytetrafluoroethylene-based AR coating is broadband, inexpensive, and can be manufactured with simple tools. The coating is field tested; AR coated focal plane elements were deployed in the 2016-2017 austral summer and AR coated reimaging optics were deployed in 2017-2018., Comment: 13 pages, 5 figures
- Published
- 2018
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- View/download PDF
47. Veranstaltungszivilrecht
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Bisges, Marcel, primary, Bahr, Henning J., additional, Bisges, Marcel, additional, Eigler, Knut, additional, Engel, Ruben, additional, Klein, Dennis, additional, Krause, Elina, additional, Lerach, Mark, additional, Mielke, Reinhard, additional, Miras, Antonio, additional, Müller, Carsten M., additional, Pahn, Boris, additional, Reitmaier, Martin, additional, and Renner, Cornelius, additional
- Published
- 2023
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- View/download PDF
48. Einführung
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Bisges, Marcel, primary, Bahr, Henning J., additional, Bisges, Marcel, additional, Eigler, Knut, additional, Engel, Ruben, additional, Klein, Dennis, additional, Krause, Elina, additional, Lerach, Mark, additional, Mielke, Reinhard, additional, Miras, Antonio, additional, Müller, Carsten M., additional, Pahn, Boris, additional, Reitmaier, Martin, additional, and Renner, Cornelius, additional
- Published
- 2023
- Full Text
- View/download PDF
49. Öffentlich-rechtliche Vorschriften
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Bisges, Marcel, primary, Bahr, Henning J., additional, Bisges, Marcel, additional, Eigler, Knut, additional, Engel, Ruben, additional, Klein, Dennis, additional, Krause, Elina, additional, Lerach, Mark, additional, Mielke, Reinhard, additional, Miras, Antonio, additional, Müller, Carsten M., additional, Pahn, Boris, additional, Reitmaier, Martin, additional, and Renner, Cornelius, additional
- Published
- 2023
- Full Text
- View/download PDF
50. The zwicky transient facility: Science objectives
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Graham, MJ, Kulkarni, SR, Bellm, EC, Adams, SM, Barbarino, C, Blagorodnova, N, Bodewits, D, Bolin, B, Brady, PR, Cenko, SB, Chang, CK, Coughlin, MW, Kishalay De, K, Eadie, G, Farnham, TL, Feindt, U, Franckowiak, A, Fremling, C, Gezari, S, Ghosh, S, Goldstein, DA, Golkhou, VZ, Goobar, A, Ho, AYQ, Huppenkothen, D, Ivezić, Ž, Jones, RL, Juric, M, Kaplan, DL, Kasliwal, MM, Kelley, MSP, Kupfer, T, Lee, CD, Lin, HW, Lunnan, R, Mahabal, AA, Miller, AA, Ngeow, CC, Nugent, P, Ofek, EO, Prince, TA, Rauch, L, Van Roestel, J, Schulze, S, Singer, LP, Sollerman, J, Taddia, F, Yan, L, Ye, QZ, Yu, PC, Barlow, T, Bauer, J, Beck, R, Belicki, J, Biswas, R, Brinnel, V, Brooke, T, Bue, B, Bulla, M, Burruss, R, Connolly, A, Cromer, J, Cunningham, V, Dekany, R, Delacroix, A, Desai, V, Duev, DA, Feeney, M, Flynn, D, Frederick, S, Gal-Yam, A, Giomi, M, Groom, S, Hacopians, E, Hale, D, Helou, G, Henning, J, Hover, D, Hillenbrand, LA, Howell, J, Hung, T, Imel, D, Ip, WH, Jackson, E, Kaspi, S, Kaye, S, Kowalski, M, Kramer, E, Kuhn, M, Landry, W, Laher, RR, Mao, P, Masci, FJ, Monkewitz, S, Murphy, P, Nordin, J, Patterson, MT, Penprase, B, Porter, M, and Rebbapragada, U
- Subjects
(stars:) supernovae: general ,surveys ,(galaxies:) quasars: general ,astro-ph.IM ,astro-ph.HE ,Astronomy & Astrophysics ,Astronomical and Space Sciences - Abstract
The Zwicky Transient Facility (ZTF), a public–private enterprise, is a new time-domain survey employing a dedicated camera on the Palomar 48-inch Schmidt telescope with a 47 deg2 field of view and an 8 second readout time. It is well positioned in the development of time-domain astronomy, offering operations at 10% of the scale and style of the Large Synoptic Survey Telescope (LSST) with a single 1-m class survey telescope. The public surveys will cover the observable northern sky every three nights in g and r filters and the visible Galactic plane every night in g and r. Alerts generated by these surveys are sent in real time to brokers. A consortium of universities that provided funding (“partnership”) are undertaking several boutique surveys. The combination of these surveys producing one million alerts per night allows for exploration of transient and variable astrophysical phenomena brighter than r∼20.5 on timescales of minutes to years. We describe the primary science objectives driving ZTF, including the physics of supernovae and relativistic explosions, multi-messenger astrophysics, supernova cosmology, active galactic nuclei, and tidal disruption events, stellar variability, and solar system objects.
- Published
- 2019
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