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1. Cerebral venous sinus thrombosis associated with cancer: analysis of the ACTION-CVT study.

Author

Vedovati, Maria, Shu, Liqi, Henninger, Nils, Zubair, Adeel, Heldner, Mirjam, Al Kasab, Sami, Siegler, James, Liebeskind, David, Antonenko, Kateryna, Yaghi, Shadi, and Paciaroni, Maurizio

Subjects
Cancer, Cerebral venous thrombosis, DOAC, Direct oral anticoagulants, Vitamin K antagonists, Humans, Neoplasms, Middle Aged, Male, Female, Sinus Thrombosis, Intracranial, Aged, Risk Factors, Adult, Hemorrhage, Recurrence, Venous Thromboembolism, Cohort Studies, Age Factors
Abstract

Nearly one fifth of patients with venous thromboembolism (VTE) have cancer. When both of these conditions occur, especially in cases of cerebral vein thrombosis (CVT), patient management is often challenging. The aim of this study was to compare the characteristics and event courses in patients affected by CVT with and without cancer. Consecutive patients with CVT from the ACTION-CVT cohort study were included if cancer status was reported. Risk factors as well as the clinical and radiological characteristics of patients were compared. Univariable and multivariable analyses were performed to assess variables associated with cancer. Kaplan-Meier method and log-rank test, logistic regression analysis, and propensity score matching were used to investigate any association between cancer-related CVT and study outcomes (primary outcome at 3-months: recurrent VTE or major hemorrhage; recurrent VTE; major hemorrhage; recanalization status; all-cause-death). Overall, 1,023 patients with CVT were included, of which 6.5% had cancer. Older age (adjusted odds ratio [aOR] 1.28 per decade increase; 95% confidence interval [CI] 1.08-1.52) and absence of headache (aOR 0.47; 95% CI 0.27-0.84) were independently associated with cancer. Patients with cancer had a higher risk of recurrent VTE or major hemorrhage (aOR 3.87; 95% CI 2.09-7.16), all-cause-death (aOR 7.56 95% CI 3.24-17.64), and major hemorrhage (aOR 3.70 95% CI 1.76-7.80). Recanalization rates, partial or complete, was not significantly different. CVT patients with cancer were more likely to be older, have no referred headache, and have worse outcomes compared to CVT patients without cancer.

Published
2024

2. Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study.

Author

Dmytriw, Adam, Musmar, Basel, Salim, Hamza, Ghozy, Sherief, Siegler, James, Kobeissi, Hassan, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh, Heit, Jeremy, Regenhardt, Robert, Cancelliere, Nicole, Bernstock, Joshua, Naamani, Kareem, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna, Puri, Ajit, Dyzmann, Christian, Kan, Peter, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas, Stapleton, Christopher, Rabinov, James, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard, Tan, Benjamin, Gopinathan, Anil, Martinez-Gutierrez, Juan, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina, Vagal, Achala, Adeeb, Nimer, Cuellar-Saenz, Hugo, Tjoumakaris, Stavropoula, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor, Möhlenbruch, Markus, Jesser, Jessica, Costalat, Vincent, Ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian, Hecker, Constantin, Kadirvel, Ramanathan, Killer-Oberpfalzer, Monika, Griessenauer, Christoph, Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David, Alexandru Radu, Răzvan, Alexandre, Andrea, Tancredi, Illario, Faizy, Tobias, Fahed, Robert, Weyland, Charlotte, Lubicz, Boris, Patel, Aman, Pereira, Vitor, and Guenego, Adrien

Subjects
AIS, MT, MeVo, Stroke, mechanical thrombectomy, perforation, Humans, Ischemic Stroke, Male, Retrospective Studies, Female, Aged, Middle Aged, Incidence, Thrombectomy, Treatment Outcome, Aged, 80 and over
Abstract

BACKGROUND: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO. METHODS: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed. RESULTS: The incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (p = 0.612). Patients with perforation had significantly worse outcomes, with lower rates of favorable angiographic outcomes (TICI 2c-3: 23% vs 58.9%, p

Published
2024

3. Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6

Author

Kühn, Anna Luisa, Puri, Ajit S., Salim, Hamza Adel, Musmar, Basel, Ghozy, Sherief, Siegler, James, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Sweid, Ahmad, Naamani, Kareem El, Hasan, Zuha, Gopinathan, Anil, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Dyzmann, Christian, Kan, Peter T., Singh, Jasmeet, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina, Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Fahed, Robert, Tancredi, Illario, Faizy, Tobias D., Weyland, Charlotte, Lubicz, Boris, Patel, Aman B., Pereira, Vitor Mendes, Guenego, Adrien, and Dmytriw, Adam A.

Published
2024
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4. First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.

Author

Radu, Răzvan, Costalat, Vincent, Fahed, Robert, Ghozy, Sherief, Siegler, James, Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh, Heit, Jeremy, Sweid, Ahmad, El Naamani, Kareem, Regenhardt, Robert, Diestro, Jose, Cancelliere, Nicole, Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna, Puri, Ajit, Dyzmann, Christian, Kan, Peter, Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Kyheng, Maéva, Marotta, Thomas, Stapleton, Christopher, Rabinov, James, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard, Tan, Benjamin, Martinez-Gutierrez, Juan, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula, Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Pedro Filipe, João, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor, Möhlenbruch, Markus, Jesser, Jessica, Tancredi, Illario, Ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph, Thomas, Ajith, Hsieh, Cheng-Yang, Liebeskind, David, Alexandre, Andrea, Faizy, Tobias, Weyland, Charlotte, Patel, Aman, Pereira, Vitor, Lubicz, Boris, Dmytriw, Adam, and Guenego, Adrien

Subjects
MeVO, Stroke, outcomes research, reperfusion, thrombectomy, Humans, Stroke, Brain Ischemia, Retrospective Studies, Thrombectomy, Treatment Outcome, Intracranial Hemorrhages
Abstract

INTRODUCTION: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce. PATIENTS AND METHODS: We conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0-2 at 3 months. RESULTS: Eight hundred thirty-six patients with a final mTICI ⩾ 2b were included in this analysis. FPE was observed in 302 patients (36.1%). In multivariable analysis, hypertension (aOR 1.55, 95% CI 1.10-2.20) and lower baseline NIHSS score (aOR 0.95, 95% CI 0.93-0.97) were independently associated with an FPE. Good outcomes were more common in the FPE versus non-FPE group (72.8% vs 52.8%), and FPE was independently associated with favorable outcome (aOR 2.20, 95% CI 1.59-3.05). 90-day mortality and intracranial hemorrhage (ICH) were significantly lower in the FPE group, 0.43 (95% CI, 0.25-0.72) and 0.55 (95% CI, 0.39-0.77), respectively. CONCLUSION: Over 2/3 of patients with MeVOs and FPE in our cohort had a favorable outcome at 90 days. FPE is independently associated with favorable outcomes, it may reduce the risk of any intracranial hemorrhage, and 3-month mortality.

Published
2024

5. Outcomes with General Anesthesia Compared to Conscious Sedation for Endovascular Treatment of Medium Vessel Occlusions: Results of an International Multicentric Study

Author

Radu, Răzvan Alexandru, Costalat, Vincent, Romoli, Michele, Musmar, Basel, Siegler, James E., Ghozy, Sherief, Khalife, Jane, Salim, Hamza, Shaikh, Hamza, Adeeb, Nimer, Cuellar-Saenz, Hugo H., Thomas, Ajith J., Kadirvel, Ramanathan, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Regenhardt, Robert W., Bernstock, Joshua D., Patel, Aman B., Rabinov, James D., Stapleton, Christopher J., Cancelliere, Nicole M., Marotta, Thomas R., Mendes Pereira, Vitor, El Naamani, Kareem, Amllay, Abdelaziz, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Meyer, Lukas, Fiehler, Jens, Faizy, Tobias D., Guerreiro, Helena, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Mounayer, Charbel, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard L. L., Tan, Benjamin YQ, Gopinathan, Anil, Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Chervak, Lina M., Vagal, Achala, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Alexandre, Andrea M., Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., YMD, Markus A., Jesser, Jessica, Weyland, Charlotte, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Aziz, Yasmin, Gory, Benjamin, Paul Stracke, Christian, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Hsieh, Cheng-Yang, Liebeskind, David S., Tancredi, Illario, Fahed, Robert, Lubicz, Boris, Essibayi, Muhammed Amir, Baker, Amanda, Altschul, David, Scarcia, Luca, Kalsoum, Erwah, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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6. Delayed Diagnosis in Cerebral Venous Thrombosis: Associated Factors and Clinical Outcomes.

Author

Bakradze, Ekaterina, Shu, Liqi, Henninger, Nils, Prabhakaran, Shyam, Siegler, James, De Marchis, Gian, Giles, James, Dittrich, Tolga, Heldner, Mirjam, Antonenko, Kateryna, Kam, Wayneho, Liebeskind, David, Simpkins, Alexis, Nguyen, Thanh, Yaghi, Shadi, and Liberman, Ava

Subjects
cerebral venous thrombosis, diagnostic error, venous thromboembolism, Humans, Delayed Diagnosis, Retrospective Studies, Venous Thrombosis, Intracranial Thrombosis, Headache, Risk Factors
Abstract

Background Identifying factors associated with delayed diagnosis of cerebral venous thrombosis (CVT) can inform future strategies for early detection. Methods and Results We conducted a retrospective cohort study including all participants from ACTION-CVT (Anticoagulation in the Treatment of Cerebral Venous Thrombosis) study who had dates of neurologic symptom onset and CVT diagnosis available. Delayed diagnosis was defined as CVT diagnosis occurring in the fourth (final) quartile of days from symptom onset. The primary study outcome was modified Rankin Scale score of ≤1 at 90 days; secondary outcomes included partial/complete CVT recanalization on last available imaging and modified Rankin Scale score of ≤2. Logistic regression analyses were used to identify independent variables associated with delayed diagnosis and to assess the association of delayed diagnosis and outcomes. A total of 935 patients were included in our study. Median time from symptom onset to diagnosis was 4 days (interquartile range, 1-10 days). Delayed CVT diagnosis (time to diagnosis >10 days) occurred in 212 patients (23%). Isolated headache (adjusted odds ratio [aOR], 2.36 [95% CI, 1.50-3.73]; P10 days after symptom onset. Delayed CVT diagnosis was associated with the symptom of isolated headache and was not associated with adverse clinical outcomes.

Published
2023

7. Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation

Author

Wang, Maud, Henkes, Hans, Ghozy, Sherief, Siegler, James E., Shaikh, Hamza, Khalife, Jane, Abdalkader, Mohamad, Klein, Piers, Nguyen, Thanh N., Heit, Jeremy J., Sweid, Ahmad, Naamani, Kareem El, Regenhardt, Robert W., Diestro, Jose Danilo Bengzon, Cancelliere, Nicole M., Amllay, Abdelaziz, Meyer, Lukas, Dusart, Anne, Bellante, Flavio, Forestier, Géraud, Rouchaud, Aymeric, Saleme, Suzana, Mounayer, Charbel, Fiehler, Jens, Kühn, Anna Luisa, Puri, Ajit S., Dyzmann, Christian, Kan, Peter T., Colasurdo, Marco, Marnat, Gaultier, Berge, Jérôme, Barreau, Xavier, Sibon, Igor, Nedelcu, Simona, Henninger, Nils, Weyland, Charlotte, Marotta, Thomas R., Stapleton, Christopher J., Rabinov, James D., Ota, Takahiro, Dofuku, Shogo, Yeo, Leonard LL., Tan, Benjamin Y. Q., Martinez-Gutierrez, Juan Carlos, Salazar-Marioni, Sergio, Sheth, Sunil, Renieri, Leonardo, Capirossi, Carolina, Mowla, Ashkan, Tjoumakaris, Stavropoula I., Jabbour, Pascal, Khandelwal, Priyank, Biswas, Arundhati, Clarençon, Frédéric, Elhorany, Mahmoud, Premat, Kevin, Valente, Iacopo, Pedicelli, Alessandro, Filipe, João Pedro, Varela, Ricardo, Quintero-Consuegra, Miguel, Gonzalez, Nestor R., Möhlenbruch, Markus A., Jesser, Jessica, Costalat, Vincent, ter Schiphorst, Adrien, Yedavalli, Vivek, Harker, Pablo, Chervak, Lina M., Aziz, Yasmin, Gory, Benjamin, Stracke, Christian Paul, Hecker, Constantin, Killer-Oberpfalzer, Monika, Griessenauer, Christoph J., Thomas, Ajith J., Hsieh, Cheng-Yang, Liebeskind, David S., Radu, Răzvan Alexandru, Alexandre, Andrea M., Tancredi, Illario, Faizy, Tobias D., Patel, Aman B., Pereira, Vitor Mendes, Fahed, Robert, Lubicz, Boris, Dmytriw, Adam A., and Guenego, Adrien

Published
2024
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9. Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial

Author

Lang, Adam Edward, de Havenon, Adam, Grory, Brian Mac, Henninger, Nils, Shu, Liqi, Furie, Karen L, Easton, J Donald, Kim, Anthony, Johnston, S Claiborne, and Yaghi, Shadi

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Prevention, Neurosciences, Stroke, Tobacco Smoke and Health, Brain Disorders, Tobacco, Clinical Research, Cancer, Good Health and Well Being, Humans, Aspirin, Clopidogrel, Hemorrhage, Ischemic Attack, Transient, Ischemic Stroke, Neoplasm Recurrence, Local, Platelet Aggregation Inhibitors, Smoking, Tobacco Smoking, tobacco, cigarettes, stroke, clopidogrel, Cardiovascular medicine and haematology, Public health
Abstract

BackgroundThe aim of this study was to determine the effect of smoking status on subsequent stroke risk in patients with minor ischemic stroke or TIA and to determine whether smoking modifies the effect of clopidogrel-based DAPT on subsequent stroke risk.MethodsThis was a post-hoc analysis of the Platelet Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) trial, which had a 90-day follow-up period. We used multivariable Cox regression and subgroup interaction analysis to determine the effect of smoking on the risk of subsequent ischemic stroke and major hemorrhage, respectively.ResultsData from 4877 participants enrolled in the POINT trial were analyzed. Among these, 1004 were current smokers and 3873 were non-smokers at the time of index event. Smoking was associated with a non-significant trend toward an increased risk of subsequent ischemic stroke during follow up (adjusted HR, 1.31 (95% CI, 0.97-1.78), p = 0.076). The effect of clopidogrel on ischemic stroke did not differ between non-smokers (HR, 0.74 (95% CI, 0.56-0.98), p = 0.03) and smokers (HR, 0.63 (95% CI, 0.37-1.05), p = 0.078), p for interaction = 0.572. Similarly, the effect of clopidogrel on major hemorrhage did not differ between non-smokers (hazard ratio, 1.67 (95% CI, 0.40-7.00), p = 0.481) and smokers (HR, 2.59 (95% CI, 1.08-6.21), p = 0.032), p for interaction = 0.613.ConclusionsIn this post-hoc analysis of the POINT trial we found that the effect of clopidogrel on reducing subsequent ischemic stroke as well as risk of major hemorrhage did not depend on smoking status, indicating that smokers benefit to a similar degree from DAPT as non-smokers.

Published
2023

10. Predictors of Recurrent Venous Thrombosis After Cerebral Venous Thrombosis: Analysis of the ACTION-CVT Study.

Author

Shu, Liqi, Bakradze, Ekaterina, Omran, Setareh, Giles, James, Amar, Jordan, Henninger, Nils, Elnazeir, Marwa, Liberman, Ava, Moncrieffe, Khadean, Rotblat, Jenny, Sharma, Richa, Cheng, Yee, Zubair, Adeel, Simpkins, Alexis, Li, Grace, Kung, Justin, Perez, Dezaray, Heldner, Mirjam, Scutelnic, Adrian, von Martial, Rascha, Siepen, Bernhard, Rothstein, Aaron, Khazaal, Ossama, Do, David, Al Kasab, Sami, Rahman, Line, Mistry, Eva, Kerrigan, Deborah, Lafever, Hayden, Nguyen, Thanh, Klein, Piers, Aparicio, Hugo, Frontera, Jennifer, Kuohn, Lindsey, Agarwal, Shashank, Stretz, Christoph, Kala, Narendra, ElJamal, Sleiman, Chang, Allison, Cutting, Shawna, Indraswari, Fransisca, de Havenon, Adam, Muddasani, Varsha, Wu, Teddy, Wilson, Duncan, Nouh, Amre, Asad, Daniyal, Qureshi, Abid, Moore, Justin, Khatri, Pooja, Aziz, Yasmin, Casteigne, Bryce, Khan, Muhib, Cheng, Yao, Grory, Brian, Weiss, Martin, Ryan, Dylan, Vedovati, Maria, Paciaroni, Maurizio, Siegler, James, Kamen, Scott, Yu, Siyuan, Guerrero, Christopher, Atallah, Eugenie, De Marchis, Gian, Brehm, Alex, Dittrich, Tolga, Psychogios, Marios, Alvarado-Dyer, Ronald, Kass-Hout, Tareq, Prabhakaran, Shyam, Honda, Tristan, Liebeskind, David, Furie, Karen, and Yaghi, Shadi

Subjects
Pregnancy, Humans, Female, Middle Aged, Male, Venous Thromboembolism, Risk Factors, Neoplasm Recurrence, Local, Intracranial Thrombosis, Venous Thrombosis, Antibodies, Antiphospholipid
Abstract

BACKGROUND AND OBJECTIVE: Cerebral venous thrombosis (CVT) is a rare cause of stroke carrying a nearly 4% risk of recurrence after 1 year. There are limited data on predictors of recurrent venous thrombosis in patients with CVT. In this study, we aim to identify those predictors. METHODS: This is a secondary analysis of the ACTION-CVT study which is a multicenter international study of consecutive patients hospitalized with a diagnosis of CVT over a 6-year period. Patients with cancer-associated CVT, CVT during pregnancy, or CVT in the setting of known antiphospholipid antibody syndrome were excluded per the ACTION-CVT protocol. The study outcome was recurrent venous thrombosis defined as recurrent venous thromboembolism (VTE) or de novo CVT. We compared characteristics between patients with vs without recurrent venous thrombosis during follow-up and performed adjusted Cox regression analyses to determine important predictors of recurrent venous thrombosis. RESULTS: Nine hundred forty-seven patients were included with a mean age of 45.2 years, 63.9% were women, and 83.6% had at least 3 months of follow-up. During a median follow-up of 308 (interquartile range 120-700) days, there were 5.05 recurrent venous thromboses (37 VTE and 24 de novo CVT) per 100 patient-years. Predictors of recurrent venous thrombosis were Black race (adjusted hazard ratio [aHR] 2.13, 95% CI 1.14-3.98, p = 0.018), history of VTE (aHR 3.40, 95% CI 1.80-6.42, p < 0.001), and the presence of one or more positive antiphospholipid antibodies (aHR 3.85, 95% CI 1.97-7.50, p < 0.001). Sensitivity analyses including events only occurring on oral anticoagulation yielded similar findings. DISCUSSION: Black race, history of VTE, and the presence of one or more antiphospholipid antibodies are associated with recurrent venous thrombosis among patients with CVT. Future studies are needed to validate our findings to better understand mechanisms and treatment strategies in patients with CVT.

Published
2022

13. External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis

Author

Klein, Piers, Shu, Liqi, Lindgren, Erik, de Winter, Maria A., Siegler, James E., Simpkins, Alexis N., Omran, Satareh Salehi, Heldner, Mirjam R., de Havenon, Adam, Abdalkader, Mohamad, al Kasab, Sami, Stretz, Christoph, Wu, Teddy Y., Wilson, Duncan, Asad, Syed Daniyal, Almallouhi, Eyad, Frontera, Jennifer, Kuohn, Lindsey, Rothstein, Aaron, Bakradze, Ekaterina, Henninger, Nils, Zubair, Adeel S., Sharma, Richa, Kerrigan, Deborah, Aziz, Yasmin, Mistry, Eva A., van Kammen, Mayte Sanchez, Tatlisumak, Turgut, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Jood, Katarina, Field, Thalia S., Yaghi, Shadi, Coutinho, Jonathan M., and Nguyen, Thanh N.

Published
2024
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15. Antiplatelet Use and Ischemic Stroke Risk in Minor Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the POINT Trial.

Author

Anadani, Mohammad, de Havenon, Adam, Henninger, Nils, Kuohn, Lindsey, Mac Grory, Brian, Furie, Karen, Johnston, S, Yaghi, Shadi, Kim, Anthony, and Easton, John Donald

Subjects
blood platelets, brain ischemia, ischemic attack, transient, ischemic stroke, stroke, Aged, Dual Anti-Platelet Therapy, Female, Humans, Ischemic Attack, Transient, Ischemic Stroke, Male, Middle Aged, Platelet Aggregation Inhibitors, Secondary Prevention
Abstract

BACKGROUND AND PURPOSE: Dual antiplatelet therapy has been shown to reduce the risk of recurrent stroke in patients with minor stroke or transient ischemic attack. However, whether the effect of dual antiplatelet therapy is modified by pretreatment antiplatelet status is unclear. METHODS: This is a post hoc analysis of the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke). Patients were divided into 2 groups based on pretreatment antiplatelet use. The primary outcome was ischemic stroke within 90 days of randomization. RESULTS: We included 4881 patients of whom 41% belonged to the no pretreatment antiplatelet. Ischemic stroke occurred in 6% and 5% in the antiplatelet pretreatment and no antiplatelet pretreatment, respectively. Antiplatelet pretreatment was not associated with the risk of ischemic stroke (adjusted hazard ratio, 1.05 [95% CI, 0.81-137]) or risk of major hemorrhage (hazard ratio, 1.10 [95% CI, 0.55-2.21]; P=0.794). The effect of dual antiplatelet therapy on recurrent ischemic stroke risk was not different in patients who were on antiplatelet before randomization (adjusted hazard ratio, 0.69 [95% CI, 0.50-0.94]) as opposed to those who were not (adjusted hazard ratio, 0.75 [95% CI, 0.50-1.12]), P for interaction = 0.685. CONCLUSIONS: In patients with minor stroke and high-risk transient ischemic attack, dual antiplatelet therapy reduces the risk of ischemic stroke regardless of premorbid antiplatelet use.

Published
2021

16. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study

Author

Yaghi, Shadi, Shu, Liqi, Mandel, Daniel, Leon Guerrero, Christopher R., Henninger, Nils, Muppa, Jayachandra, Affan, Muhammad, Ul Haq Lodhi, Omair, Heldner, Mirjam R., Antonenko, Kateryna, Seiffge, David, Arnold, Marcel, Salehi Omran, Setareh, Crandall, Ross, Lester, Evan, Lopez Mena, Diego, Arauz, Antonio, Nehme, Ahmad, Boulanger, Marion, Touze, Emmanuel, Sousa, Joao Andre, Sargento-Freitas, Joao, Barata, Vasco, Castro-Chaves, Paulo, Brito, Maria Teresa, Khan, Muhib, Mallick, Dania, Rothstein, Aaron, Khazaal, Ossama, Kaufmann, Josefin E., Engelter, Stefan T., Traenka, Christopher, Aguiar de Sousa, Diana, Soares, Mafalda, Rosa, Sara, Zhou, Lily W., Gandhi, Preet, Field, Thalia S., Mancini, Steven, Metanis, Issa, Leker, Ronen R., Pan, Kelly, Dantu, Vishnu, Baumgartner, Karl, Burton, Tina, Von Rennenberg, Regina, Nolte, Christian H., Choi, Richard, MacDonald, Jason, Bavarsad Shahripour, Reza, Guo, Xiaofan, Ghannam, Malik, Almajali, Mohammad, Samaniego, Edgar A., Sanchez, Sebastian, Rioux, Bastien, Zine-Eddine, Faycal, Poppe, Alexandre, Fonseca, Ana Catarina, Baptista, Maria Fortuna, Cruz, Diana, Romoli, Michele, De Marco, Giovanna, Longoni, Marco, Keser, Zafer, Griffin, Kim, Kuohn, Lindsey, Frontera, Jennifer, Amar, Jordan, Giles, James, Zedde, Marialuisa, Pascarella, Rosario, Grisendi, Ilaria, Nzwalo, Hipolito, Liebeskind, David S., Molaie, Amir, Cavalier, Annie, Kam, Wayneho, Mac Grory, Brian, Al Kasab, Sami, Anadani, Mohammad, Kicielinski, Kimberly, Eltatawy, Ali, Chervak, Lina, Chulluncuy-Rivas, Roberto, Aziz, Yasmin, Bakradze, Ekaterina, Tran, Thanh Lam, Rodrigo-Gisbert, Marc, Requena, Manuel, Saleh Velez, Faddi, Ortiz Gracia, Jorge, Mudassani, Varsha, de Havenon, Adam, Vishnu, Venugopalan Y., Yaddanapudi, Sridhara, Adams, Latasha, Browngoehl, Abigail, Ranasinghe, Tamra, Dunston, Randy, Lynch, Zachary, Penckofer, Mary, Siegler, James, Mayer, Silvia, Willey, Joshua, Zubair, Adeel, Cheng, Yee Kuang, Sharma, Richa, Marto, João Pedro, Mendes Ferreira, Vítor, Klein, Piers, Nguyen, Thanh N., Asad, Syed Daniyal, Sarwat, Zoha, Balabhadra, Anvesh, Patel, Shivam, Secchi, Thais, Martins, Sheila, Mantovani, Gabriel, Kim, Young Dae, Krishnaiah, Balaji, Elangovan, Cheran, Lingam, Sivani, Quereshi, Abid, Fridman, Sebastian, Alvarado, Alonso, Khasiyev, Farid, Linares, Guillermo, Mannino, Marina, Terruso, Valeria, Vassilopoulou, Sofia, Tentolouris, Vasilis, Martinez-Marino, Manuel, Carrasco Wall, Victor, Indraswari, Fransisca, El Jamal, Sleiman, Liu, Shilin, Alvi, Muhammad, Ali, Farman, Sarvath, Mohammed, Morsi, Rami Z., Kass-Hout, Tareq, Shi, Feina, Zhang, Jinhua, Sokhi, Dilraj, Said, Jamil, Simpkins, Alexis N., Gomez, Roberto, Sen, Shayak, Ghani, Mohammad, Elnazeir, Marwa, Xiao, Han, Kala, Narendra, Khan, Farhan, Stretz, Christoph, Mohammadzadeh, Nahid, Goldstein, Eric, and Furie, Karen

Published
2024
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17. Transcarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Study-Level Meta-Analysis

Author

Ghannam, Malik, AlMajali, Mohammad, Khasiyev, Farid, Dibas, Mahmoud, Al Qudah, Abdullah, AlMajali, Fawaz, Ghazaleh, Dana, Shah, Asghar, Fayad, Fayez H., Joudi, Kareem, Zaidat, Bashar, Childs, Christopher A., Levy, Bennett R., Abouainain, Yasmeen, Özdemir-van Brunschot, Denise M.D., Shu, Liqi, Goldstein, Eric D., Baig, Ammad A., Roeder, Hannah, Henninger, Nils, de Havenon, Adam, Levy, Elad I., Matouk, Charles, Derdeyn, Colin P., Leira, Enrique C., Chaturvedi, Seemant, and Yaghi, Shadi

Published
2024
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19. Carotid Stenosis and Recurrent Ischemic Stroke: A Post-Hoc Analysis of the POINT Trial.

Author

Yaghi, Shadi, de Havenon, Adam, Rostanski, Sara, Kvernland, Alexandra, Mac Grory, Brian, Furie, Karen L, Kim, Anthony S, Easton, J Donald, Johnston, S Claiborne, and Henninger, Nils

Subjects
Humans, Brain Ischemia, Carotid Stenosis, Recurrence, Aspirin, Platelet Aggregation Inhibitors, Retrospective Studies, Follow-Up Studies, Aged, Aged, 80 and over, Middle Aged, Female, Male, Stroke, Clopidogrel, Dual Anti-Platelet Therapy, aspirin, carotid stenosis, clopidogrel, ischemic stroke, proportional hazards models, Clinical Trials and Supportive Activities, Brain Disorders, Atherosclerosis, Clinical Research, Neurosciences, Prevention, Hematology, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeRandomized trials demonstrated the benefit of dual antiplatelet therapy in patients with minor ischemic stroke or high-risk transient ischemic attack. We sought to determine whether the presence of carotid stenosis was associated with increased risk of ischemic stroke and whether the addition of clopidogrel to aspirin was associated with more benefit in patients with versus without carotid stenosis.MethodsThis is a post-hoc analysis of the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke) that randomized patients with minor ischemic stroke or high-risk transient ischemic attack within 12 hours from last known normal to receive either clopidogrel plus aspirin or aspirin alone. The primary predictor was the presence of ≥50% stenosis in either cervical internal carotid artery. The primary outcome was ischemic stroke. We built Cox regression models to determine the association between carotid stenosis and ischemic stroke and whether the effect of clopidogrel was modified by ≥50% carotid stenosis.ResultsAmong 4881 patients enrolled POINT, 3941 patients met the inclusion criteria. In adjusted models, ≥50% carotid stenosis was associated with ischemic stroke risk (hazard ratio, 2.45 [95% CI, 1.68-3.57], P

Published
2021

21. Which Spreading Depolarizations Are Deleterious To Brain Tissue?

Author

Shuttleworth, C William, Andrew, R David, Akbari, Yama, Ayata, Cenk, Balu, Ramani, Brennan, KC, Boutelle, Martyn, Carlson, Andrew P, Dreier, Jens P, Fabricius, Martin, Farkas, Eszter, Foreman, Brandon, Helbok, Raimund, Henninger, Nils, Jewell, Sharon L, Jones, Stephen C, Kirov, Sergei A, Lindquist, Britta E, Maciel, Carolina B, Okonkwo, David, Reinhart, Katelyn M, Robertson, R Meldrum, Rosenthal, Eric S, Watanabe, Tomas, and Hartings, Jed A

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Brain Disorders, Animals, Brain, Brain Injuries, Cortical Spreading Depression, Electroencephalography, Humans, Migraine with Aura, Spreading depression, Spreading depolarization, Ischemia, Trauma, Subarachnoid hemorrhage, Neurology & Neurosurgery, Clinical sciences, Nursing
Abstract

Spreading depolarizations (SDs) are profound disruptions of cellular homeostasis that slowly propagate through gray matter and present an extraordinary metabolic challenge to brain tissue. Recent work has shown that SDs occur commonly in human patients in the neurointensive care setting and have established a compelling case for their importance in the pathophysiology of acute brain injury. The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in September of 2018 included a discussion session focused on the question of "Which SDs are deleterious to brain tissue?" iCSD is attended by investigators studying various animal species including invertebrates, in vivo and in vitro preparations, diseases of acute brain injury and migraine, computational modeling, and clinical brain injury, among other topics. The discussion included general agreement on many key issues, but also revealed divergent views on some topics that are relevant to the design of clinical interventions targeting SDs. A draft summary of viewpoints offered was then written by a multidisciplinary writing group of iCSD members, based on a transcript of the session. Feedback of all discussants was then formally collated, reviewed and incorporated into the final document. It is hoped that this report will stimulate collection of data that are needed to develop a more nuanced understanding of SD in different pathophysiological states, as the field continues to move toward effective clinical interventions.

Published
2020

25. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro

Author

Meijboom, Katharina E., Abdallah, Abbas, Fordham, Nicholas P., Nagase, Hiroko, Rodriguez, Tomás, Kraus, Carolyn, Gendron, Tania F., Krishnan, Gopinath, Esanov, Rustam, Andrade, Nadja S., Rybin, Matthew J., Ramic, Melina, Stephens, Zachary D., Edraki, Alireza, Blackwood, Meghan T., Kahriman, Aydan, Henninger, Nils, Kocher, Jean-Pierre A., Benatar, Michael, Brodsky, Michael H., Petrucelli, Leonard, Gao, Fen-Biao, Sontheimer, Erik J., Brown, Robert H., Zeier, Zane, and Mueller, Christian

Published
2022
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27. Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke

Author

Salim, Hamza, primary, Musmar, Basel, additional, Adeeb, Nimer, additional, Yedavalli, Vivek, additional, Lakhani, Dhairya, additional, Grewal, Sahibjot Singh, additional, El Naamani, Kareem, additional, Henninger, Nils, additional, Sundararajan, Sri Hari, additional, Kühn, Anna Luisa, additional, Khalife, Jane, additional, Ghozy, Sherief, additional, Scarcia, Luca, additional, Tan, Benjamin YQ, additional, Regenhardt, Robert W, additional, Heit, Jeremy J, additional, Cancelliere, Nicole M, additional, Bernstock, Joshua D, additional, Rouchaud, Aymeric, additional, Fiehler, Jens, additional, Sheth, Sunil, additional, Puri, Ajit S, additional, Dyzmann, Christian, additional, Colasurdo, Marco, additional, Barreau, Xavier, additional, Renieri, Leonardo, additional, Filipe, João Pedro, additional, Harker, Pablo, additional, Radu, Răzvan Alexandru, additional, Abdalkader, Mohamad, additional, Klein, Piers, additional, Marotta, Thomas R, additional, Spears, Julian, additional, Ota, Takahiro, additional, Mowla, Ashkan, additional, Jabbour, Pascal, additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Siegler, James E, additional, Nguyen, Thanh N, additional, Varela, Ricardo, additional, Baker, Amanda, additional, Essibayi, Muhammed Amir, additional, Altschul, David, additional, Gonzalez, Nestor R, additional, Möhlenbruch, Markus A, additional, Costalat, Vincent, additional, Gory, Benjamin, additional, Stracke, Christian Paul, additional, Aziz-Sultan, Mohammad Ali, additional, Hecker, Constantin, additional, Shaikh, Hamza, additional, Liebeskind, David S, additional, Pedicelli, Alessandro, additional, Alexandre, Andrea M, additional, Tancredi, Illario, additional, Faizy, Tobias D, additional, Kalsoum, Erwah, additional, Lubicz, Boris, additional, Patel, Aman B, additional, Pereira, Vitor Mendes, additional, Guenego, Adrien, additional, Dmytriw, Adam A, additional, Amllay, Abdelaziz, additional, Vagal, Achala, additional, ter Schiphorst, Adrien, additional, Thomas, Ajith J., additional, Gopinathan, Anil, additional, Dusart, Anne, additional, Capirossi, Carolina, additional, Mounayer, Charbel, additional, Weyland, Charlotte, additional, Hsieh, Cheng-Yang, additional, Griessenauer, Christoph J., additional, Stapleton, Christopher J., additional, Bellante, Flavio, additional, Marnat, Gaultier, additional, Forestier, Géraud, additional, Cuellar-Saenz, Hugo H., additional, Valente, Iacopo, additional, Sibon, Igor, additional, Rabinov, James D., additional, Berge, Jérôme, additional, Jesser, Jessica, additional, Carlos Martinez-Gutierrez, Juan, additional, Premat, Kevin, additional, Yeo, Leonard LL., additional, Chervak, Lina, additional, Meyer, Lukas, additional, Elhorany, Mahmoud, additional, and Quintero-Consuegra, Miguel, additional

Published
2024
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29. Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System

Author

Kvernland, Alexandra, Kumar, Arooshi, Yaghi, Shadi, Raz, Eytan, Frontera, Jennifer, Lewis, Ariane, Czeisler, Barry, Kahn, D. Ethan, Zhou, Ting, Ishida, Koto, Torres, Jose, Riina, Howard A., Shapiro, Maksim, Nossek, Erez, Nelson, Peter K., Tanweer, Omar, Gordon, David, Jain, Rajan, Dehkharghani, Seena, Henninger, Nils, de Havenon, Adam, Grory, Brian Mac, Lord, Aaron, and Melmed, Kara

Published
2021
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32. External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis

Author

MS Interne Geneeskunde, Klein, Piers, Shu, Liqi, Lindgren, Erik, de Winter, Maria A., Siegler, James E., Simpkins, Alexis N., Omran, Satareh Salehi, Heldner, Mirjam R., de Havenon, Adam, Abdalkader, Mohamad, al Kasab, Sami, Stretz, Christoph, Wu, Teddy Y., Wilson, Duncan, Asad, Syed Daniyal, Almallouhi, Eyad, Frontera, Jennifer, Kuohn, Lindsey, Rothstein, Aaron, Bakradze, Ekaterina, Henninger, Nils, Zubair, Adeel S., Sharma, Richa, Kerrigan, Deborah, Aziz, Yasmin, Mistry, Eva A., van Kammen, Mayte Sanchez, Tatlisumak, Turgut, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Jood, Katarina, Field, Thalia S., Yaghi, Shadi, Coutinho, Jonathan M., Nguyen, Thanh N., MS Interne Geneeskunde, Klein, Piers, Shu, Liqi, Lindgren, Erik, de Winter, Maria A., Siegler, James E., Simpkins, Alexis N., Omran, Satareh Salehi, Heldner, Mirjam R., de Havenon, Adam, Abdalkader, Mohamad, al Kasab, Sami, Stretz, Christoph, Wu, Teddy Y., Wilson, Duncan, Asad, Syed Daniyal, Almallouhi, Eyad, Frontera, Jennifer, Kuohn, Lindsey, Rothstein, Aaron, Bakradze, Ekaterina, Henninger, Nils, Zubair, Adeel S., Sharma, Richa, Kerrigan, Deborah, Aziz, Yasmin, Mistry, Eva A., van Kammen, Mayte Sanchez, Tatlisumak, Turgut, Krzywicka, Katarzyna, Aguiar de Sousa, Diana, Jood, Katarina, Field, Thalia S., Yaghi, Shadi, Coutinho, Jonathan M., and Nguyen, Thanh N.

Published
2024

34. Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation

Author

Yaghi, Shadi, Liberman, Ava L., Henninger, Nils, Grory, Brian Mac, Nouh, Amre, Scher, Erica, Giles, James, Liu, Angela, Nagy, Muhammad, Kaushal, Ashutosh, Azher, Idrees, Fakhri, Hiba, Espaillat, Kiersten Brown, Asad, Syed Daniyal, Pasupuleti, Hemanth, Martin, Heather, Tan, Jose, Veerasamy, Manivannan, Esenwa, Charles, Cheng, Natalie, Moncrieffe, Khadean, Moeini-Naghani, Iman, Siddu, Mithilesh, Trivedi, Tushar, Ishida, Koto, Frontera, Jennifer, Lord, Aaron, Furie, Karen, Keyrouz, Salah, de Havenon, Adam, Mistry, Eva, Leon Guerrero, Christopher R., and Khan, Muhib

Published
2020
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36. 12 versus 24 h bed rest after acute ischemic stroke thrombolysis: a preliminary experience

Author

Silver, Brian, Hamid, Tariq, Khan, Muhib, Di Napoli, Mario, Behrouz, Reza, Saposnik, Gustavo, Sarafin, Jo-Ann, Martin, Susan, Moonis, Majaz, Henninger, Nils, Goddeau, Richard, Jun-O'Connell, Adalia, Cutting, Shawna M., Saad, Ali, Yaghi, Shadi, Hall, Wiley, Muehlschlegel, Susanne, Carandang, Raphael, Osgood, Marcey, Thompson, Bradford B., Fehnel, Corey R., Wendell, Linda C., Potter, N. Stevenson, Gilchrist, James M., and Barton, Bruce

Published
2020
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37. Abstract WP268: Transcarotid Arterial Revascularization of Symptomatic Internal Carotid Artery Disease: A Systematic Review and Meta-Analysis

Author

Ghannam, Malik, primary, Almajali, Mohammad, additional, Al Qudah, Abdullah, additional, Khasiyev, Farid, additional, Dibas, Mahmoud, additional, Ghazaleh, Dana, additional, Roeder, Hannah, additional, Henninger, Nils, additional, de Havenon, Adam H, additional, Derdeyn, Colin P, additional, Leira, Enrique C, additional, Chaturvedi, Seemant, additional, and Yaghi, Shadi, additional

Published
2024
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38. Abstract TMP62: The Delayed Seizure CVT Score Predicts Delayed Seizure After Cerebral Venous Thrombosis - A Secondary Analysis of ACTION-CVT

Author

Stretz, Christoph, primary, Shu, Liqi, additional, Kala, Narendra S, additional, El JAMAL, SLEIMAN, additional, Heldner, Mirjam, additional, Bakradze, Ekaterina, additional, Sharma, Richa, additional, Zubair, Adeel, additional, Henninger, Nils, additional, Rothstein, Aaron, additional, Salehi Omran, Setareh, additional, Klein, Piers, additional, Nguyen, Thanh, additional, Kuohn, Lindsey, additional, Frontera, Jennifer, additional, Kerrigan, Deborah, additional, Al Kasab, Sami, additional, Aziz, Yasmin, additional, Wu, Teddy, additional, Siegler, James E, additional, Asad, Syed Daniyal, additional, Furie, Karen L, additional, and Yaghi, Shadi, additional

Published
2024
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39. Abstract TMP108: External Validation of the SI 2 NCAL 2 C Score for Mortality Following Cerebral Venous Thrombosis

Author

Klein, Piers, primary, Shu, Liqi, additional, Lindgren, Erik, additional, de Winter, Maria A, additional, Siegler, James E, additional, Simpkins, Alexis N, additional, Salehi Omran, Setareh, additional, Heldner, Mirjam, additional, de Havenon, Adam H, additional, Abdalkader, Mohamad, additional, Al Kasab, Sami, additional, Stretz, Christoph, additional, Wu, Teddy, additional, Wilson, Duncan, additional, Asad, Syed Daniyal, additional, Almallouhi, Eyad, additional, Frontera, Jennifer, additional, Kuohn, Lindsey, additional, Rothstein, Aaron, additional, Bakradze, Ekaterina, additional, Henninger, Nils, additional, Zubair, Adeel S, additional, Sharma, Richa, additional, Kerrigan, Deborah, additional, Aziz, Yasmin, additional, Mistry, Eva, additional, Sanchez van Kammen, Mayte, additional, Tatlisumak, Turgut, additional, Krzywicka, Katarzyna, additional, Aguiar De Sousa, Diana, additional, Jood, Katarina, additional, Field, Thalia S, additional, Yaghi, Shadi, additional, Coutinho, Jonathan M, additional, and Nguyen, Thanh N, additional

Published
2024
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40. Endovascular Therapy vs. Best Medical Management in Distal Medium Middle Cerebral Artery Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study

Author

Salim, Hamza A., primary, Yedavalli, Vivek, additional, Musmar, Basel, additional, Adeeb, Nimer, additional, Naamani, Kareem El, additional, Henninger, Nils, additional, Sundararajan, Sri Hari, additional, Kuhn, Anna Luisa, additional, Khalife, Jane, additional, Ghozy, Sherief, additional, Scarcia, Luca, additional, Tan, Benjamin YQ, additional, Heit, Jeremy J., additional, Regenhardt, Robert, additional, Cancelliere, Nicole M., additional, Bernstock, Joshua D., additional, Rouchaud, Aymeric, additional, Fiehler, Jens, additional, Sheth, Sunil A., additional, Essibayi, Muhammed Amir, additional, Puri, Ajit S., additional, Dyzmann, Christian, additional, Colasurdo, Marco, additional, Barreau, Xavier, additional, Renieri, Leonardo, additional, Filipe, João Pedro, additional, Harker, Pablo, additional, Radu, Răzvan Alexandru, additional, Marotta, Thomas R., additional, Spears, Julian, additional, Ota, Takahiro, additional, Mowla, Ashkan, additional, Jabbour, Pascal M., additional, Biswas, Arundhati, additional, Clarençon, Frédéric, additional, Siegler, James E., additional, Nguyen, Thanh N., additional, Varela, Ricardo, additional, Baker, Amanda, additional, Altschul, David, additional, Gonzalez, Nestor R., additional, Mohlenbruch, Markus, additional, Costalat, Vincent, additional, Gory, Benjamin, additional, Stracke, Christian Paul, additional, Aziz-Sultan, Ali, additional, Hecker, Constantin, additional, Shaikh, Hamza, additional, Liebeskind, David S., additional, Pedicelli, Alessandro, additional, Alexandre, Andrea M., additional, Tancredi, Illario, additional, Faizy, Tobias D., additional, Kalsoum, Erwah, additional, Lubicz, Boris, additional, Patel, Aman B., additional, Pereira, Vitor Mendes, additional, Guenego, Adrien, additional, and Dmytriw, Adam A., additional

Published
2024
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42. Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study

Author

Yaghi, Shadi, Shu, Liqi, Bakradze, Ekaterina, Salehi Omran, Setareh, Giles, James A., Amar, Jordan Y., Henninger, Nils, Elnazeir, Marwa, Liberman, Ava L., Moncrieffe, Khadean, Lu, Jenny, Sharma, Richa, Cheng, Yee, Zubair, Adeel S., Simpkins, Alexis N., Li, Grace T., Kung, Justin Chi, Perez, Dezaray, Heldner, Mirjam, Scutelnic, Adrian, Seiffge, David, Siepen, Bernhard, Rothstein, Aaron, Khazaal, Ossama, Do, David, Kasab, Sami Al, Rahman, Line Abdul, Mistry, Eva A., Kerrigan, Deborah, Lafever, Hayden, Nguyen, Thanh N., Klein, Piers, Aparicio, Hugo, Frontera, Jennifer, Kuohn, Lindsey, Agarwal, Shashank, Stretz, Christoph, Kala, Narendra, El Jamal, Sleiman, Chang, Alison, Cutting, Shawna, Xiao, Han, de Havenon, Adam, Muddasani, Varsha, Wu, Teddy, Wilson, Duncan, Nouh, Amre, Asad, Syed Daniyal, Qureshi, Abid, Moore, Justin, Khatri, Pooja, Aziz, Yasmin, Casteigne, Bryce, Khan, Muhib, Cheng, Yao, Mac Grory, Brian, Weiss, Martin, Ryan, Dylan, Vedovati, Maria Cristina, Paciaroni, Maurizio, Siegler, James E., Kamen, Scott, Yu, Siyuan, Leon Guerrero, Christopher R., Atallah, Eugenie, De Marchis, Gian Marco, Brehm, Alex, Dittrich, Tolga, Psychogios, Marios, Alvarado-Dyer, Ronald, Kass-Hout, Tareq, Prabhakaran, Shyam, Honda, Tristan, Liebeskind, David S., and Furie, Karen

Published
2022
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50. Anticoagulation Versus Antiplatelets in Spontaneous Cervical Artery Dissection: A Systematic Review and Meta-Analysis

Author

Yaghi, Shadi, Shu, Liqi, Fletcher, Lauren, Fayad, Fayez H., Shah, Asghar, Herning, Ana, Isho, Noail, Mansour, Perla, Joudi, Kareem, Zaidat, Bashar, Mahmoud, Noor A., Abdul Khalek, Feras, Xiao, Han, Goldstein, Eric, Ghannam, Malik, Siegler, James E., Salehi Omran, Setareh, Bakradze, Ekaterina, Nguyen, Thanh N., Keser, Zafer, Khan, Muhib, Bavarsad Shahripour, Reza, de Havenon, Adam, Henninger, Nils, Heldner, Mirjam R., Field, Thalia S., Aziz, Yasmin, Mistry, Eva A., Furie, Karen, Engelter, Stefan, and Markus, Hugh S.

Published
2024
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