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42 results on '"Hennis, A. J. M."'

1. Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction

Author

Jia, Guochong, Ping, Jie, Guo, Xingyi, Yang, Yaohua, Tao, Ran, Li, Bingshan, Ambs, Stefan, Barnard, Mollie E., Chen, Yu, Garcia-Closas, Montserrat, Gu, Jian, Hu, Jennifer J., Huo, Dezheng, John, Esther M., Li, Christopher I., Li, James L., Nathanson, Katherine L., Nemesure, Barbara, Olopade, Olufunmilayo I., Pal, Tuya, Press, Michael F., Sanderson, Maureen, Sandler, Dale P., Shu, Xiao-Ou, Troester, Melissa A., Yao, Song, Adejumo, Prisca O., Ahearn, Thomas, Brewster, Abenaa M., Hennis, Anselm J. M., Makumbi, Timothy, Ndom, Paul, O’Brien, Katie M., Olshan, Andrew F., Oluwasanu, Mojisola M., Reid, Sonya, Butler, Ebonee N., Huang, Maosheng, Ntekim, Atara, Qian, Huijun, Zhang, Haoyu, Ambrosone, Christine B., Cai, Qiuyin, Long, Jirong, Palmer, Julie R., Haiman, Christopher A., and Zheng, Wei

Published
2024
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2. Using genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes

Author

Ping, Jie, Jia, Guochong, Cai, Qiuyin, Guo, Xingyi, Tao, Ran, Ambrosone, Christine, Huo, Dezheng, Ambs, Stefan, Barnard, Mollie E., Chen, Yu, Garcia-Closas, Montserrat, Gu, Jian, Hu, Jennifer J., John, Esther M., Li, Christopher I., Nathanson, Katherine, Nemesure, Barbara, Olopade, Olufunmilayo I., Pal, Tuya, Press, Michael F., Sanderson, Maureen, Sandler, Dale P., Yoshimatsu, Toshio, Adejumo, Prisca O., Ahearn, Thomas, Brewster, Abenaa M., Hennis, Anselm J. M., Makumbi, Timothy, Ndom, Paul, O’Brien, Katie M., Olshan, Andrew F., Oluwasanu, Mojisola M., Reid, Sonya, Yao, Song, Butler, Ebonee N., Huang, Maosheng, Ntekim, Atara, Li, Bingshan, Troester, Melissa A., Palmer, Julie R., Haiman, Christopher A., Long, Jirong, and Zheng, Wei

Published
2024
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3. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Author

Wang, Anqi, Shen, Jiayi, Rodriguez, Alex A., Saunders, Edward J., Chen, Fei, Janivara, Rohini, Darst, Burcu F., Sheng, Xin, Xu, Yili, Chou, Alisha J., Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Plym, Anna, Sahimi, Ali, Hoffman, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Laisk, Triin, Figuerêdo, Jéssica, Muir, Kenneth, Ito, Shuji, Liu, Xiaoxi, Uchio, Yuji, Kubo, Michiaki, Kamatani, Yoichiro, Lophatananon, Artitaya, Wan, Peggy, Andrews, Caroline, Lori, Adriana, Choudhury, Parichoy P., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Borge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Andreas, Stroomberg, Hein V., Batra, Jyotsna, Chambers, Suzanne, Horvath, Lisa, Clements, Judith A., Tilly, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordstrom, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie, Cook, Michael B., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Koutros, Stella, Beane Freeman, Laura E., Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Butler, Ebonee N., Mohler, James L., Taylor, Jack A., Kogevinas, Manolis, Dierssen-Sotos, Trinidad, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Pilie, Patrick, Yu, Yao, Bohlender, Ryan J., Gu, Jian, Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Brenner, Hermann, Chen, Xuechen, Holleczek, Bernd, Schöttker, Ben, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine M., Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Abraham, Aswin, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer, Petrovics, Gyorgy, Casey, Graham, Wang, Ying, Tettey, Yao, Lachance, Joseph, Tang, Wei, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Yamoah, Kosj, Govindasami, Koveela, Chokkalingam, Anand P., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Diop, Halimatou, Gundell, Susan M., Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Kachuri, Linda, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Preuss, Michael H., Loos, Ruth J. F., Zawistowski, Matthew, Zöllner, Sebastian, Lu, Zeyun, Van Den Eeden, Stephen K., Easton, Douglas F., Ambs, Stefan, Edwards, Todd L., Mägi, Reedik, Rebbeck, Timothy R., Fritsche, Lars, Chanock, Stephen J., Berndt, Sonja I., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Gaziano, J. Michael, Justice, Amy C., Mancuso, Nick, Terao, Chikashi, Eeles, Rosalind A., Kote-Jarai, Zsofia, Madduri, Ravi K., Conti, David V., and Haiman, Christopher A.

Published
2023
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5. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V., Darst, Burcu F., Moss, Lilit C., Saunders, Edward J., Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R., Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Sahimi, Ali, Hoffmann, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R., Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A., Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Geybels, Milan S., Koutros, Stella, Freeman, Laura E. Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Fontham, Elizabeth T. H., Mohler, James, Taylor, Jack A., Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine, Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I., Van Den Eeden, Stephen K., Easton, Douglas F., Chanock, Stephen J., Cook, Michael B., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Eeles, Rosalind A., Kote-Jarai, Zsofia, and Haiman, Christopher A.

Published
2021
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6. Diabetes mortality: trends and multi-country analysis of the Americas from 2000 to 2019.

Author

Antini, Carmen, Caixeta, Roberta, Luciani, Silvana, and Hennis, Anselm J M

Subjects
TREND analysis, DIABETIC nephropathies, COVID-19, MEDICAL quality control, MORTALITY, DIABETES
Abstract

Background Diabetes has been increasing worldwide and is now among the 10 leading causes of death globally. Diabetic kidney disease (DKD), a complication of poorly managed diabetes, is related to high mortality risk. To better understand the situation in the Americas region, we evaluated diabetes and DKD mortality trends over the past 20 years. Methods We analysed diabetes and DKD mortality for 33 countries in the Americas from 2000 to 2019. Data were extracted from the World Health Organization (WHO) Global Health Estimates and the World Population Prospects, 2019 Revision, estimating annual age-standardized mortality rates (ASMR) and gaps in the distribution of diabetes and DKD mortality by sex and country. Trend analyses were based on the annual average percentage of change (AAPC). Results From 2000 to 2019, the overall mortality trend from diabetes in the Americas remained stable [AAPC: -0.2% (95% CI: -0.4%–0.0%]; however, it showed important differences by sex and by country over time. By contrast, DKD mortality increased 1.5% (1.3%–1.6%) per year, rising faster in men than women, with differences between countries. Central America, Mexico and the Latin Caribbean showed significant increases in mortality for both diseases, especially DKD. In contrast in North America, diabetes mortality decreased whereas DKD mortality increased. Conclusions The increase in DKD mortality is evidence of poorly controlled diabetes in the region. The lack of programmes on prevention of complications, self-care management and gaps in quality health care may explain this trend and highlight the urgent need to build more robust health systems based on primary care, prioritizing diabetes prevention and control. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry

Author

Darst, Burcu F., primary, Shen, Jiayi, additional, Madduri, Ravi K, additional, Rodriguez, Alexis A, additional, Xiao, Yukai, additional, Sheng, Xin, additional, Saunders, Edward J., additional, Dadaev, Tokhir, additional, Brook, Mark N, additional, Hoffmann, Thomas J, additional, Muir, Kenneth, additional, Wan, Peggy, additional, Le Marchand, Loic, additional, Wilkens, Lynne, additional, Wang, Ying, additional, Schleutker, Johanna, additional, MacInnis, Robert J, additional, Cybulski, Cezary, additional, Neal, David E, additional, Nordestgaard, Borge G, additional, Nielsen, Sune F, additional, Batra, Jyotsna, additional, Clements, Judith A, additional, Gronberg, Henrik, additional, Pashayan, Nora, additional, Travis, Ruth C, additional, Park, Jong Y, additional, Albanes, Demetrius, additional, Weinstein, Stephanie, additional, Mucci, Lorelei A, additional, Hunter, David J, additional, Penney, Kathryn L, additional, Tangen, Catherine M, additional, Hamilton, Robert J, additional, Parent, Marie-Elise, additional, Stanford, Janet L, additional, Koutros, Stella, additional, Wolk, Alicja, additional, Sorensen, Karina Dalsgaard, additional, Blot, William J, additional, Yeboah, Edward D, additional, Mensah, James E, additional, Lu, Yong-Jie, additional, Schaid, Daniel J, additional, Thibodeau, Stephen N, additional, West, Catharine ML, additional, Maier, Christiane, additional, Kibel, Adam S, additional, Cancel-Tassin, Geraldine, additional, Menegaux, Florence, additional, John, Esther M, additional, Grindedal, Eli Marie, additional, Khaw, Kay-Tee, additional, Ingles, Sue A, additional, Vega, Ana, additional, Rosenstein, Barry S, additional, Teixeira, Manuel R, additional, Kogevinas, Manolis, additional, Cannon-Albright, Lisa, additional, Huff, Chad, additional, Multigner, Luc, additional, Kaneva, Radka, additional, Leach, Robin J, additional, Brenner, Hermann, additional, Hsing, Ann W, additional, Kittles, Rick A, additional, Murphy, Adam B, additional, Logothetis, Christopher J, additional, Neuhausen, Susan L, additional, Isaacs, William B, additional, Nemesure, Barbara, additional, Hennis, Anselm J M, additional, Carpten, John, additional, Pandha, Hardev, additional, De Ruyck, Kim, additional, Xu, Jianfeng, additional, Razack, Azad, additional, Teo, Soo-Hwang, additional, Newcomb, Lisa F, additional, Fowke, Jay H, additional, Neslund-Dudas, Christine, additional, Rybicki, Benjamin A, additional, Gamulin, Marija, additional, Usmani, Nawaid, additional, Claessens, Frank, additional, Gago-Dominguez, Manuela, additional, Castelao, Jose Esteban, additional, Townsend, Paul A, additional, Crawford, Dana C, additional, Petrovics, Gyorgy, additional, Casey, Graham, additional, Roobol, Monique J, additional, Hu, Jennifer F, additional, Berndt, Sonja I, additional, Van Den Eeden, Stephen K, additional, Easton, Douglas F, additional, Chanock, Stephen J, additional, Cook, Michael B, additional, Wiklund, Fredrik, additional, Witte, John S, additional, Eeles, Rosalind A., additional, Kote-Jarai, Zsofia, additional, Watya, Stephen, additional, Gaziano, John Michael, additional, Justice, Amy C, additional, Conti, David V., additional, and Haiman, Christopher A., additional

Published
2023
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8. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V., Darst, Burcu F., Moss, Lilit C., Saunders, Edward J., Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R., Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Sahimi, Ali, Hoffmann, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R., Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A., Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Geybels, Milan S., Koutros, Stella, Freeman, Laura E. Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Fontham, Elizabeth T. H., Mohler, James, Taylor, Jack A., Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine, Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I., Van Den Eeden, Stephen K., Easton, Douglas F., Chanock, Stephen J., Cook, Michael B., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Eeles, Rosalind A., Kote-Jarai, Zsofia, and Haiman, Christopher A.

Published
2021
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11. Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions

Author

Han, Ying, Hazelett, Dennis J., Wiklund, Fredrik, Schumacher, Fredrick R., Stram, Daniel O., Berndt, Sonja I., Wang, Zhaoming, Rand, Kristin A., Hoover, Robert N., Machiela, Mitchell J., Yeager, Merideth, Burdette, Laurie, Chung, Charles C., Hutchinson, Amy, Yu, Kai, Xu, Jianfeng, Travis, Ruth C., Key, Timothy J., Siddiq, Afshan, Canzian, Federico, Takahashi, Atsushi, Kubo, Michiaki, Stanford, Janet L., Kolb, Suzanne, Gapstur, Susan M., Diver, W. Ryan, Stevens, Victoria L., Strom, Sara S., Pettaway, Curtis A., Al Olama, Ali Amin, Kote-Jarai, Zsofia, Eeles, Rosalind A., Yeboah, Edward D., Tettey, Yao, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P., Isaacs, William B., Chen, Constance, Lindstrom, Sara, Le Marchand, Loic, Giovannucci, Edward L., Pomerantz, Mark, Long, Henry, Li, Fugen, Ma, Jing, Stampfer, Meir, John, Esther M., Ingles, Sue A., Kittles, Rick A., Murphy, Adam B., Blot, William J., Signorello, Lisa B., Zheng, Wei, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Nemesure, Barbara, Carpten, John, Leske, M. Cristina, Wu, Suh-Yuh, Hennis, Anselm J. M., Rybicki, Benjamin A., Neslund-Dudas, Christine, Hsing, Ann W., Chu, Lisa, Goodman, Phyllis J., Klein, Eric A., Zheng, S. Lilly, Witte, John S., Casey, Graham, Riboli, Elio, Li, Qiyuan, Freedman, Matthew L., Hunter, David J., Gronberg, Henrik, Cook, Michael B., Nakagawa, Hidewaki, Kraft, Peter, Chanock, Stephen J., Easton, Douglas F., Henderson, Brian E., Coetzee, Gerhard A., Conti, David V., and Haiman, Christopher A.

Published
2015
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16. Educational Health Disparities in Cardiovascular Disease Risk Factors: Findings from Jamaica Health and Lifestyle Survey 2007–2008

Author

Ferguson, Trevor S., primary, Younger-Coleman, Novie O. M., additional, Tulloch-Reid, Marshall K., additional, Hambleton, Ian R., additional, Francis, Damian K., additional, Bennett, Nadia R., additional, McFarlane, Shelly R., additional, Bidulescu, Aurelian, additional, MacLeish, Marlene Y., additional, Hennis, Anselm J. M., additional, Wilks, Rainford J., additional, Harris, E. Nigel, additional, and Sullivan, Louis W., additional

Published
2017
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17. Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults

Author

Chu, Lisa, Goodman, Phyllis, Berndt, Sonja I., Ambrosone, Christine B., Monroe, Kristine R., Hsing, Ann W., Bandera, Elisa V., Carpten, John, Millikan, Robert C., Chen, Fang, He, Jing, Cai, Qiuyin, Kolb, Suzanne, Cheng, Iona, Murphy, Adam, Thomas, Venetta, Chanock, Stephen J., Blot, William J., Driver, W. Ryan, Casey, Graham, Ingles, Sue A., Kittles, Rick A., Leske, M. Cristina, Bernstein, Leslie, Nemesure, Barbara, John, Esther M., Zhang, Jianqi, Chen, Gary K., Hu, Jennifer J., Deming, Sandra L., Hayes, Richard B., and Hennis, Anselm J. M.

Abstract

Height has an extremely polygenic pattern of inheritance. Genome-wide association studies (GWAS) have revealed hundreds of common variants that are associated with human height at genome-wide levels of significance. However, only a small fraction of phenotypic variation can be explained by the aggregate of these common variants. In a large study of African-American men and women (n = 14,419), we genotyped and analyzed 966,578 autosomal SNPs across the entire genome using a linear mixed model variance components approach implemented in the program GCTA (Yang et al Nat Genet 2010), and estimated an additive heritability of 44.7% (se: 3.7%) for this phenotype in a sample of evidently unrelated individuals. While this estimated value is similar to that given by Yang et al in their analyses, we remain concerned about two related issues: (1) whether in the complete absence of hidden relatedness, variance components methods have adequate power to estimate heritability when a very large number of SNPs are used in the analysis; and (2) whether estimation of heritability may be biased, in real studies, by low levels of residual hidden relatedness. We addressed the first question in a semi-analytic fashion by directly simulating the distribution of the score statistic for a test of zero heritability with and without low levels of relatedness. The second question was addressed by a very careful comparison of the behavior of estimated heritability for both observed (self-reported) height and simulated phenotypes compared to imputation R2 as a function of the number of SNPs used in the analysis. These simulations help to address the important question about whether today's GWAS SNPs will remain useful for imputing causal variants that are discovered using very large sample sizes in future studies of height, or whether the causal variants themselves will need to be genotyped de novo in order to build a prediction model that ultimately captures a large fraction of the variability of height, and by implication other complex phenotypes. Our overall conclusions are that when study sizes are quite large (5,000 or so) the additive heritability estimate for height is not apparently biased upwards using the linear mixed model; however there is evidence in our simulation that a very large number of causal variants (many thousands) each with very small effect on phenotypic variance will need to be discovered to fill the gap between the heritability explained by known versus unknown causal variants. We conclude that today's GWAS data will remain useful in the future for causal variant prediction, but that finding the causal variants that need to be predicted may be extremely laborious.

Published
2015
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18. Prostate Cancer Susceptibility in Men of African Ancestry at 8q24

Author

Han, Ying, primary, Rand, Kristin A., additional, Hazelett, Dennis J., additional, Ingles, Sue A., additional, Kittles, Rick A., additional, Strom, Sara S., additional, Rybicki, Benjamin A., additional, Nemesure, Barbara, additional, Isaacs, William B., additional, Stanford, Janet L., additional, Zheng, Wei, additional, Schumacher, Fredrick R., additional, Berndt, Sonja I., additional, Wang, Zhaoming, additional, Xu, Jianfeng, additional, Rohland, Nadin, additional, Reich, David, additional, Tandon, Arti, additional, Pasaniuc, Bogdan, additional, Allen, Alex, additional, Quinque, Dominique, additional, Mallick, Swapan, additional, Notani, Dimple, additional, Rosenfeld, Michael G., additional, Jayani, Ranveer Singh, additional, Kolb, Suzanne, additional, Gapstur, Susan M., additional, Stevens, Victoria L., additional, Pettaway, Curtis A., additional, Yeboah, Edward D., additional, Tettey, Yao, additional, Biritwum, Richard B., additional, Adjei, Andrew A., additional, Tay, Evelyn, additional, Truelove, Ann, additional, Niwa, Shelley, additional, Chokkalingam, Anand P., additional, John, Esther M., additional, Murphy, Adam B., additional, Signorello, Lisa B., additional, Carpten, John, additional, Leske, M. Cristina, additional, Wu, Suh-Yuh, additional, Hennis, Anslem J. M., additional, Neslund-Dudas, Christine, additional, Hsing, Ann W., additional, Chu, Lisa, additional, Goodman, Phyllis J., additional, Klein, Eric A., additional, Zheng, S. Lilly, additional, Witte, John S., additional, Casey, Graham, additional, Lubwama, Alex, additional, Pooler, Loreall C., additional, Sheng, Xin, additional, Coetzee, Gerhard A., additional, Cook, Michael B., additional, Chanock, Stephen J., additional, Stram, Daniel O., additional, Watya, Stephen, additional, Blot, William J., additional, Conti, David V., additional, Henderson, Brian E., additional, and Haiman, Christopher A., additional

Published
2016
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21. Prevalence and phenotype of diabetes and prediabetes using fasting glucose vs HbA1c in a Caribbean population.

Author

Unwin, Nigel, Howitt, Christina, Rose, Angela M. C., Samuels, T. Alafia, Hennis, Anselm J. M., and Hambleton, Ian R.

Abstract

Background Both fasting plasma glucose (FPG) and HbA1c are recommended for the diagnosis of diabetes and prediabetes by the American Diabetes Association (ADA), and for diabetes by the World Health Organization. The ADA guidance is influential on clinical practice in many developing countries, including in the Caribbean and Latin America. We aimed to compare the prevalence and characteristics of individuals identified as having diabetes and prediabetes by FPG and HbA1c in a predominantly African ancestry Caribbean population. Methods A representative population-based sample of 1234 adults (≥25 years of age) resident in Barbados was recruited. Standard methods with appropriate quality control were used to collect data on height, weight, blood pressure, fasting lipids and history of diagnosed diabetes, and to measure fasting glucose and HbA1c. Those with previously diagnosed diabetes (n = 192) were excluded from the analyses. Diabetes was defined as: FPG ≥7.0 mmol/L or HbA1c ≥6.5%; prediabetes as: FPG ≥5.6 to <7mmol/L or HbA1c ≥5.7 to <6.5%. Results Complete data were available on 939 participants without previously diagnosed diabetes. The prevalence of undiagnosed diabetes was higher, but not significantly so, by HbA1c (4.9%, 95% CI 3.5, 6.8) vs FPG (3.5%, 2.4, 5.1). Overall 79 individuals had diabetes by either measure, but only 21 on both. The prevalence of prediabetes was higher by HbA1c compared to FPG: 41.7% (37.9, 45.6) vs 15.0% (12.8, 17.5). Overall 558 individuals had prediabetes by either measure, but only 107 on both. HbA1c, but not FPG, was significantly higher in women than men; and FPG, but not HbA1c, was significantly associated with raised triglycerides and low HDL cholesterol. Conclusion The agreement between FPG and HbA1c defined hyperglycaemia is poor. In addition, there are some differences in the phenotype of those identified, and HbA1c gives a much higher prevalence of prediabetes. The routine use of HbA1c for screening and diagnosis in this population would have major implications for clinical and public health policies and resources. Given the lack of robust evidence, particularly for prediabetes, on whether intervention in the individuals identified would improve outcomes, this approach to screening and diagnosis cannot be currently recommended for this population. [ABSTRACT FROM AUTHOR]

Published
2017
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22. Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults

Author

Chen, Fang, primary, He, Jing, additional, Zhang, Jianqi, additional, Chen, Gary K., additional, Thomas, Venetta, additional, Ambrosone, Christine B., additional, Bandera, Elisa V., additional, Berndt, Sonja I., additional, Bernstein, Leslie, additional, Blot, William J., additional, Cai, Qiuyin, additional, Carpten, John, additional, Casey, Graham, additional, Chanock, Stephen J., additional, Cheng, Iona, additional, Chu, Lisa, additional, Deming, Sandra L., additional, Driver, W. Ryan, additional, Goodman, Phyllis, additional, Hayes, Richard B., additional, Hennis, Anselm J. M., additional, Hsing, Ann W., additional, Hu, Jennifer J., additional, Ingles, Sue A., additional, John, Esther M., additional, Kittles, Rick A., additional, Kolb, Suzanne, additional, Leske, M. Cristina, additional, Millikan, Robert C., additional, Monroe, Kristine R., additional, Murphy, Adam, additional, Nemesure, Barbara, additional, Neslund-Dudas, Christine, additional, Nyante, Sarah, additional, Ostrander, Elaine A, additional, Press, Michael F., additional, Rodriguez-Gil, Jorge L., additional, Rybicki, Ben A., additional, Schumacher, Fredrick, additional, Stanford, Janet L., additional, Signorello, Lisa B., additional, Strom, Sara S., additional, Stevens, Victoria, additional, Van Den Berg, David, additional, Wang, Zhaoming, additional, Witte, John S., additional, Wu, Suh-Yuh, additional, Yamamura, Yuko, additional, Zheng, Wei, additional, Ziegler, Regina G., additional, Stram, Alexander H., additional, Kolonel, Laurence N., additional, Marchand, Loïc Le, additional, Henderson, Brian E., additional, Haiman, Christopher A., additional, and Stram, Daniel O., additional

Published
2015
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25. Leveraging population admixture to characterize the heritability of complex traits

Author

Zaitlen, Noah, primary, Pasaniuc, Bogdan, additional, Sankararaman, Sriram, additional, Bhatia, Gaurav, additional, Zhang, Jianqi, additional, Gusev, Alexander, additional, Young, Taylor, additional, Tandon, Arti, additional, Pollack, Samuela, additional, Vilhjálmsson, Bjarni J, additional, Assimes, Themistocles L, additional, Berndt, Sonja I, additional, Blot, William J, additional, Chanock, Stephen, additional, Franceschini, Nora, additional, Goodman, Phyllis G, additional, He, Jing, additional, Hennis, Anselm J M, additional, Hsing, Ann, additional, Ingles, Sue A, additional, Isaacs, William, additional, Kittles, Rick A, additional, Klein, Eric A, additional, Lange, Leslie A, additional, Nemesure, Barbara, additional, Patterson, Nick, additional, Reich, David, additional, Rybicki, Benjamin A, additional, Stanford, Janet L, additional, Stevens, Victoria L, additional, Strom, Sara S, additional, Whitsel, Eric A, additional, Witte, John S, additional, Xu, Jianfeng, additional, Haiman, Christopher, additional, Wilson, James G, additional, Kooperberg, Charles, additional, Stram, Daniel, additional, Reiner, Alex P, additional, Tang, Hua, additional, and Price, Alkes L, additional

Published
2014
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26. Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers

Author

Zheng, Y., primary, Ogundiran, T. O., additional, Falusi, A. G., additional, Nathanson, K. L., additional, John, E. M., additional, Hennis, A. J. M., additional, Ambs, S., additional, Domchek, S. M., additional, Rebbeck, T. R., additional, Simon, M. S., additional, Nemesure, B., additional, Wu, S.-Y., additional, Leske, M. C., additional, Odetunde, A., additional, Niu, Q., additional, Zhang, J., additional, Afolabi, C., additional, Gamazon, E. R., additional, Cox, N. J., additional, Olopade, C. O., additional, Olopade, O. I., additional, and Huo, D., additional

Published
2013
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29. Predicting the burden of acute myocardial infarction in a country with limited resources: combining data from routine sources.

Author

Rose, Angela M. C., Belgrave, Nico R. S., Maul, Lauren, Hennis, Anselm J. M., Delice, Rudy, and Hambleton, Ian R.

Subjects
DISEASE incidence, MYOCARDIAL infarction risk factors, BURDEN of care, CARDIOVASCULAR diseases, PATIENTS, SURVEILLANCE detection
Abstract

Background: Prior to implementation of a national surveillance system for cardiovascular disease in Barbados, a small island state with limited health resources, the national burden of acute myocardial infarction (MI) was unknown. Methods: We retrospectively estimated national acute MI incidence rates (IRs) per 100 000 during the decade before registry implementation (1999-2008), using easily accessible routine data from different sources, assessing changes over time through Poisson regression. Future events (2009-2013) were estimated using simple sensitivity analysis to incorporate prediction uncertainty. Model predictions were compared with actual IRs from initial years of the registry. Results: In 2000, crude IR was 85.5 (95% CI 74.9-97.2), rising to 92.1 (81.2-103.9) in 2008. Accounting for population ageing, the model anticipated IR of 115.9 in 2010 (99.7-132.1), vs actual crude IR 129.7 (115.9-144.6). Conclusions: Despite no electronic medical record system in Barbados, data were simple to collect, and provided a rough baseline for acute MI burden.We show that, in countries with small populations, limited resources and in absence of surveillance, national mortality statistics and routine hospital data can be combined to adequately model national estimates of acute MI incidence. This cheap and simple, yet fairly accurate method could be a key tool for other low-resource countries with ageing populations and increasing cardiovascular disease levels. [ABSTRACT FROM AUTHOR]

Published
2016
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30. Disparities in hypertension among black Caribbean populations: a scoping review by the U.S. Caribbean Alliance for Health Disparities Research Group (USCAHDR).

Author

Bidulescu, Aurelian, Francis, Damian K., Ferguson, Trevor S., Bennett, Nadia R., Hennis, Anselm J. M., Wilks, Rainford, Harris, Eon N., MacLeish, Marlene, and Sullivan, Louis W.

Subjects
HYPERTENSION epidemiology, BLACK people, HEALTH status indicators, HYPERTENSION, POPULATION geography, RACE, WHITE people, SYSTEMATIC reviews, LITERATURE reviews, SOCIOECONOMIC factors, THEMATIC analysis, HEALTH equity, CROSS-sectional method, DISEASE complications
Abstract

Background: Despite the large body of research on racial/ethnic disparities in health, there are limited data on health disparities in Caribbean-origin populations. This scoping review aimed to analyze and synthesize published and unpublished literature on the disparities in hypertension and its complications among Afro-Caribbean populations. Methods: A comprehensive protocol, including a thorough search strategy, was developed and used to identify potentially relevant studies. Identified studies were then screened for eligibility using pre-specified inclusion/exclusion criteria. An extraction form was developed to chart data and collate study characteristics including methods and main findings. Charted information was tagged by disparity indicators and thematic analysis performed. Disparity indicators evaluated include ethnicity, sex, socioeconomic status, disability, sexual orientation and geographic location. Gaps in the literature were identified and extrapolated into a gap map. Results: A total of 455 hypertension related records, published between 1972 and 2012, were identified and screened. Twenty-one studies met inclusion criteria for detailed analysis. The majority of studies were conducted in the United Kingdom and utilized a cross-sectional study design. Overall, studies reported a higher prevalence of hypertension among Caribbean blacks compared to West African blacks and Caucasians. Hypertension and its related complications were highest in persons with low socioeconomic status. Gap analysis showed limited research data reporting hypertension incidence by sex and socioeconomic status. No literature was found on disability status or sexual orientation as it relates to hypertension. Prevalence and morbidity were the most frequently reported outcomes. Conclusion: The literature on hypertension health disparities in Caribbean origin populations is limited. Future research should address these knowledge gaps and develop approaches to reduce them. [ABSTRACT FROM AUTHOR]

Published
2015
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31. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Author

Haiman, Christopher A, primary, Chen, Gary K, additional, Blot, William J, additional, Strom, Sara S, additional, Berndt, Sonja I, additional, Kittles, Rick A, additional, Rybicki, Benjamin A, additional, Isaacs, William B, additional, Ingles, Sue A, additional, Stanford, Janet L, additional, Diver, W Ryan, additional, Witte, John S, additional, Hsing, Ann W, additional, Nemesure, Barbara, additional, Rebbeck, Timothy R, additional, Cooney, Kathleen A, additional, Xu, Jianfeng, additional, Kibel, Adam S, additional, Hu, Jennifer J, additional, John, Esther M, additional, Gueye, Serigne M, additional, Watya, Stephen, additional, Signorello, Lisa B, additional, Hayes, Richard B, additional, Wang, Zhaoming, additional, Yeboah, Edward, additional, Tettey, Yao, additional, Cai, Qiuyin, additional, Kolb, Suzanne, additional, Ostrander, Elaine A, additional, Zeigler-Johnson, Charnita, additional, Yamamura, Yuko, additional, Neslund-Dudas, Christine, additional, Haslag-Minoff, Jennifer, additional, Wu, William, additional, Thomas, Venetta, additional, Allen, Glenn O, additional, Murphy, Adam, additional, Chang, Bao-Li, additional, Zheng, S Lilly, additional, Leske, M Cristina, additional, Wu, Suh-Yuh, additional, Ray, Anna M, additional, Hennis, Anselm J M, additional, Thun, Michael J, additional, Carpten, John, additional, Casey, Graham, additional, Carter, Erin N, additional, Duarte, Edder R, additional, Xia, Lucy Y, additional, Sheng, Xin, additional, Wan, Peggy, additional, Pooler, Loreall C, additional, Cheng, Iona, additional, Monroe, Kristine R, additional, Schumacher, Fredrick, additional, Le Marchand, Loic, additional, Kolonel, Laurence N, additional, Chanock, Stephen J, additional, Berg, David Van Den, additional, Stram, Daniel O, additional, and Henderson, Brian E, additional

Published
2011
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34. Disparities in cardiovascular disease among Caribbean populations: a systematic literature review.

Author

Francis, Damian K., Bennett, Nadia R., Ferguson, Trevor S., Hennis, Anselm J. M., Wilks, Rainford J., Harris, E. Nigel, MacLeish, Marlene M. Y., and Sullivan, Louis W.

Abstract

Background: Cardiovascular diseases (CVD) are the predominant cause of death globally. The large health disparities in the distribution of the burden of disease seen in developed and developing countries are of growing concern. Central to this concern is the poor outcome which is seen disproportionately in socially disadvantaged groups and racial/ethnic minorities. The aim of the study was to conduct a systematic literature review to investigate the nature of cardiovascular disease health disparities among Afro-Caribbean origin populations and identify current knowledge gaps. Methods: A systematic literature review including a detailed search strategy was developed to search MEDLINE and other research databases. Using an a priori protocol peer-reviewed publications and grey literature articles were retrieved and screened and relevant data extracted by two independent review authors. Thematic analysis was done according to CVD outcomes and measures of disparity including age, sex, ethnicity and socioeconomic status. Results: The search retrieved 665 articles of which 22 met the inclusion criteria. Most studies were conducted in the United Kingdom and centered on the prevalence of CVD by ethnicity, age and sex. An important sub-theme identified was the disparities in health service utilization/hospital admission. Coronary Heart Disease (CHD) and Peripheral Arterial Disease (PAD) were less prevalent among Afro-Caribbeans compared to Caucasian and South East Asian ethnic groups. The prevalence of CHD ranged from 0-7 % in Afro-Caribbean to 2-22 % in Caucasians. Strokes were more common among Afro-Caribbeans. There are inadequate data on morbidity and mortality from CVD, particularly across the socio-economic gradient, in Afro-Caribbean populations. Conclusions: There are important differences in morbidity and mortality from CVD across ethnic groups. Important knowledge gaps remain in understanding the social determinants of these disparities in CVD. More research exploring these gaps by varying disparity indicators needs to be undertaken. [ABSTRACT FROM AUTHOR]

Published
2015
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35. Disparities in diabetes mellitus among Caribbean populations: a scoping review.

Author

Bennett, Nadia R., Francis, Damian K., Ferguson, Trevor S., Hennis, Anselm J. M., Wilks, Rainford J., Harris, Eon Nigel, MacLeish, Marlene M. Y., and Sullivan, Louis W.

Subjects
DIABETES, MORTALITY, TREATMENT of diabetes, BLACK people, DATABASES, PEOPLE with diabetes, ETHNIC groups, HEALTH, HEALTH services accessibility, HEALTH status indicators, MEDICAL databases, INFORMATION storage & retrieval systems, RESEARCH methodology, MEDLINE, POPULATION, RACE, DATA analysis
Abstract

Background: Despite the large body of research on racial/ethnic disparities in health, there are limited data on health disparities in Caribbean origin populations. This review aims to analyze and synthesize published literature on the disparities in diabetes mellitus (DM) and its complications among Afro-Caribbean populations. Methods: A detailed protocol, including a comprehensive search strategy, was developed and used to identify potentially relevant studies. Identified studies were then screened for eligibility using pre-specified inclusion and exclusion criteria. An extraction form was developed to chart data and collate study characteristics including methods and main findings. Charted information was tagged by disparity indicators and thematic analysis performed. Disparity indicators evaluated include ethnicity, sex, age, socioeconomic status, disability and geographic location. Gaps in the literature were identified and extrapolated into a gap map. Results: A total of 1009 diabetes related articles/manuscripts, published between 1972 and 2013, were identified and screened. Forty-three studies met inclusion criteria for detailed analysis. Most studies were conducted in the United Kingdom, Trinidad and Tobago and Jamaica, and used a cross-sectional study design. Overall, studies reported a higher prevalence of DM among Caribbean Blacks compared to West African Blacks and Caucasians but lower when compared to South Asian origin groups. Morbidity from diabetes-related complications was highest in persons with low socioeconomic status. Gap analysis showed limited research data reporting diabetes incidence by sex and socioeconomic status. No published literature was found on disability status or sexual orientation as it relates to diabetes burden or complications. Prevalence and morbidity were the most frequently reported outcomes. Conclusion: Literature on diabetes health disparities in Caribbean origin populations is limited. Future research should address these knowledge gaps and develop approaches to reduce them. [ABSTRACT FROM AUTHOR]

Published
2015
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36. Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Author

Gusev, Alexander, Shi, Huwenbo, Kichaev, Gleb, Pomerantz, Mark, Li, Fugen, Long, Henry W., Ingles, Sue A., Kittles, Rick A., Strom, Sara S., Rybicki, Benjamin A., Nemesure, Barbara, Isaacs, William B., Zheng, Wei, Pettaway, Curtis A., Yeboah, Edward D., Tettey, Yao, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P., John, Esther M., Murphy, Adam B., Signorello, Lisa B., Carpten, John, Leske, M. Cristina, Wu, Suh-Yuh, Hennis, Anslem J. M., Neslund-Dudas, Christine, Hsing, Ann W., Chu, Lisa, Goodman, Phyllis J., Klein, Eric A., Witte, John S., Casey, Graham, Kaggwa, Sam, Cook, Michael B., Stram, Daniel O., Blot, William J., Eeles, Rosalind A., Easton, Douglas, Kote-Jarai, ZSofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G., Southey, Melissa C., Fitzgerald, Liesel M., Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Henderson, Brian E., Schleutker, Johanna, Wahlfors, Tiina, Tammela, Teuvo L. J., Nordestgaard, Børge G., Key, Tim J., Travis, Ruth C., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Pharoah, Paul, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L., Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S., Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa, Teerlink, Craig, Brenner, Hermann, Dieffenbach, Aida K., Arndt, Volker, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Spurdle, Amanda, Clements, Judith A., Teixeira, Manuel R., Pandha, Hardev, Michael, Agnieszka, Paulo, Paula, Maia, Sofia, Kierzek, Andrzej, Cook, Margaret, Guy, Michelle, Govindasami, Koveela, Leongamornlert, Daniel, Sawyer, Emma J., Wilkinson, Rosemary, Saunders, Edward J., Tymrakiewicz, Malgorzata, Dadaev, Tokhir, Morgan, Angela, Fisher, Cyril, Hazel, Steve, Livni, Naomi, Lophatananon, Artitaya, Pedersen, John, Hopper, John L., Adolfson, Jan, Stattin, Paer, Johansson, Jan-Erik, Cavalli-Bjoerkman, Carin, Karlsson, Ami, Broms, Michael, Auvinen, Anssi, Kujala, Paula, Maeaettaenen, Liisa, Murtola, Teemu, Taari, Kimmo, Weischer, Maren, Nielsen, Sune F., Klarskov, Peter, Roder, Andreas, Iversen, Peter, Wallinder, Hans, Gustafsson, Sven, Cox, Angela, Brown, Paul, George, Anne, Marsden, Gemma, Lane, Athene, Davis, Michael, Tillmans, Lori, Riska, Shaun, Wang, Liang, Rinckleb, Antje, Lubiski, Jan, Stegmaier, Christa, Pow-Sang, Julio, Park, Hyun, Radlein, Selina, Rincon, Maria, Haley, James, Zachariah, Babu, Kachakova, Darina, Popov, Elenko, Mitkova, Atanaska, Vlahova, Aleksandrina, Dikov, Tihomir, Christova, Svetlana, Heathcote, Peter, Wood, Glenn, Malone, Greg, Saunders, Pamela, Eckert, Allison, Yeadon, Trina, Kerr, Kris, Collins, Angus, Turner, Megan, Srinivasan, Srilakshmi, Kedda, Mary-Anne, Alexander, Kimberly, Omara, Tracy, Wu, Huihai, Henrique, Rui, Pinto, Pedro, Santos, Joana, Barros-Silva, Joao, Conti, David V., Albanes, Demetrius, Berg, Christine, Berndt, Sonja I., Campa, Daniele, Crawford, E. David, Diver, W. Ryan, Gapstur, Susan M., Gaziano, J. Michael, Giovannucci, Edward, Hoover, Robert, Hunter, David J., Johansson, Mattias, Kraft, Peter, Le Marchand, Loic, Lindström, Sara, Navarro, Carmen, Overvad, Kim, Riboli, Elio, Siddiq, Afshan, Stevens, Victoria L., Trichopoulos, Dimitrios, Vineis, Paolo, Yeager, Meredith, Trynka, Gosia, Raychaudhuri, Soumya, Schumacher, Frederick R., Price, Alkes L., Freedman, Matthew L., Haiman, Christopher A., and Pasaniuc, Bogdan

Abstract

Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.

Published
2016
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37. Systemic lupus erythematosus in an African Caribbean population: Incidence, clinical manifestations, and survival in the Barbados National Lupus Registry.

Author

Flower, Cindy, Hennis, Anselm J. M., Hambleton, Ian R., Nicholson, George D., and Liang, Matthew H.

Abstract

Objective To assess the epidemiology, clinical features, and outcomes of systemic lupus erythematosus (SLE) in the predominantly African Caribbean population of Barbados. Methods A national registry of all patients diagnosed with SLE was established in 2007. Complete case ascertainment was facilitated by collaboration with the island's sole rheumatology service, medical practitioners, and the lupus advocacy group. Informed consent was required for inclusion. Results Between January 1, 2000 and December 31, 2009, there were 183 new cases of SLE (98% African Caribbean) affecting 172 women and 11 men for unadjusted annual incidence rates of 12.21 (95% confidence interval [95% CI] 10.46-14.18) and 0.84 (95% CI 0.42-1.51) per 100,000 person-years, respectively. Excluding pediatric cases (ages <18 years), the unadjusted incidence rate among women was 15.14 per 100,000 person-years. The principal presenting manifestations were arthritis (84%), nephritis (47%), pleuritis (41.5%), malar rash (36.4%), and discoid lesions (33.1%). Antinuclear antibody positivity was 95%. The overall 5-year survival rate was 79.9% (95% CI 69.6-87.1), decreasing to 68% in patients with nephritis. A total of 226 persons with SLE were alive at the end of the study for point prevalences of 152.6 (95% CI 132.8-174.5) and 10.1 (95% CI 5.4-17.2) per 100,000 among women and men, respectively. Conclusion Rates of SLE in Barbadian women are among the highest reported to date, with clinical manifestations similar to African American women and high mortality. Further study of this population and similar populations of West African descent might assist our understanding of environmental, genetic, and health care issues underpinning disparities in SLE. [ABSTRACT FROM AUTHOR]

Published
2012
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38. Prostate Cancer Incidence and Mortality in Barbados,West Indies.

Author

Hennis, Anselm J. M., Hambleton, Ian R., Wu, Suh-Yuh, Skeete, Desiree H. A., Nemesure, Barbara, and Leske, M. Cristina

Subjects
*PROSTATE cancer, *DISEASE incidence, *CANCER-related mortality, CANCER histopathology
Abstract

We describe prostate cancer incidence and mortality in Barbados, West Indies. We ascertained all histologically confirmed cases of prostate cancer during the period July 2002 to December 2008 and reviewed each death registration citing prostate cancer over a 14-year period commencing January 1995. There were 1101 new cases for an incidence rate of 160.4 (95% Confidence Interval: 151.0-170.2) per 100,000 standardized to the US population. Comparable rates in African-American and White American men were 248.2 (95% CI: 246.0-250.5) and 158.0 (95% CI: 157.5-158.6) per 100,000, respectively. Prostate cancer mortality rates in Barbados ranged from 63.2 to 101.6 per 100,000, compared to 51.1 to 78.8 per 100,000 among African Americans. Prostate cancer risks are lower in Caribbean-origin populations than previously believed, while mortality rates appeared to be higher than reported in African-American men. Studies in Caribbean populations may assist understanding of disparities among Africanorigin populations with shared heredity. [ABSTRACT FROM AUTHOR]

Published
2011
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39. Nutritional composition of the commonly consumed composite dishes for the Barbados National Cancer Study.

Author

Sharma, Sangita, Harris, Rachel, Cao, Xia, Hennis, Anselm J. M., Leske, M. Cristina, and Wu, Suh-Yuh

Subjects
NUTRITION, RECIPES (Non-food), PROSTATE, BREAST cancer
Abstract

Primary Objective: To provide, for the first time, the calculated nutritional composition of 32 composite dishes commonly consumed in Barbados to enable dietary intake to be calculated from a Quantitative Food Frequency Questionnaire developed specifically for this population to determine associations between diet and risk of prostate and breast cancer.Methods and Procedures: Weighed recipes were collected in up to six different households for each of the 32 composite dishes. The average nutritional composition for these composite dishes was calculated using the US Department of Agriculture National Nutrient Database.Main Outcomes and Results: One hundred and fifty-two weighed recipes were collected for 32 composite dishes: five were fish based, two were ground beef dishes, two were chicken based, two were offal based, two were lamb dishes, one was pork based, three were rice based, three were commonly consumed home-made drinks, and the remaining were miscellaneous items.Conclusions: A total of 152 weighed recipes were collected and we provide, for the first time, nutritional composition data for 32 commonly consumed food and drink items in Barbados. Such data are essential for assessing nutrient intake and determining associations between diet and prostate and breast cancer in the Barbados National Cancer Study. [ABSTRACT FROM AUTHOR]

Published
2007
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40. Dietary intake and development of a quantitative food-frequency questionnaire for the Barbados National Cancer Study.

Author

Sharma S, Cao X, Harris R, Hennis AJ, Leske MC, Wu SY, Barbados National Cancer Study Group, Sharma, Sangita, Cao, Xia, Harris, Rachel, Hennis, Anselm J M, Leske, M Cristina, and Wu, Suh-Yuh

Abstract

Objective: To develop a quantitative food-frequency questionnaire (QFFQ) for the Barbados National Cancer Study (BNCS) that will permit examination of associations of diet with breast and prostate cancer.Design: Population intake data from the year 2000 Barbados Food Consumption and Anthropometric Surveys (BFCAS 2000) were used to derive a list of foods consumed by the population. A 192-item draft QFFQ was developed from this list.Setting: Barbados, West Indies provides an ideal environment to understand cancer risk in African-origin populations, with high relevance to African-Americans. The BNCS is a population-based case-control study examining risk factors for breast and prostate cancer in such populations.Subjects: A total of 1600 persons, 18 years and older, completed a 24-hour recall in the BFCAS 2000. Fifty of 63 randomly selected residents (79% response rate) gave additional updated information on foods consumed.Results: The 50 participants provided a one-time 24-hour recall and completed the draft QFFQ. The final instrument contains 148 items: breads, cakes, cereals = 17; rice, pastas, noodles = 8; dairy = 10; meat, fish, poultry = 42; fruit = 16; vegetables = 26; soft drinks = 14; alcoholic beverages = 5; others = 10. Additional questions include supplement use and food preparation methods such as grilling.Conclusion: The final instrument is concise, complete and the most up-to-date for assessing the food and nutrient intake of African-origin Barbadians and the associations with breast and prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2007
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41. Explanations for the high risk of diabetes-related amputation in a Caribbean population of black african descent and potential for prevention.

Author

Hennis, Anselm J. M., Fraser, Henry S., Jonnalagaoda, Ramesh, Fuller, John, Chaturvedi, Nish, and Jonnalagadda, Ramesh

Subjects
*DIABETES, *LEG amputation, *AMPUTATION, *DISEASE risk factors, *PERIPHERAL vascular diseases
Abstract

Objective: Diabetes-related lower-extremity amputation (LEA) rates are elevated in blacks compared with whites in the U.S., but are lower in African Caribbeans in the U.K., whereas anecdotal reports suggest high rates in the Caribbean. We aimed to establish the incidence and risk factors for diabetes-related LEA in a Caribbean population.Research Design and Methods: We conducted an incident and prospective case-control study of case patients (individuals with diabetes having a LEA) and community-based control subjects (individuals with diabetes without a LEA) in Barbados, West Indies. Participants completed an interview and examination of risk factors for amputation, including footwear use.Results: The overall 1-year incidence of LEA (n = 223) was 173 per 10(5) population and 936 per 10(5) population with diabetes (557 per 10(5) for minor amputation and 379 per 10(5) for major amputation). Women had higher amputation rates than those reported in the Global Lower Extremity Amputation Study, apart from the U.S. Navajo population. Independent risk factors for all diabetes-related LEAs were poor footwear (odds ratio [OR] 2.71 [95% CI 1.23-5.97]), elevated GHb (1.40 per percent increase [1.26-1.57]), peripheral neuropathy (1.05 per volt increase [1.03-1.08]), and peripheral vascular disease.Conclusions: Diabetes LEA rates in Barbados are among the highest in the world. Inadequate footwear independently tripled amputation risk. Education of professionals and patients, particularly about footwear and foot care, coupled with improved diabetes clinical care, is key to reducing amputation risk in this population. [ABSTRACT FROM AUTHOR]

Published
2004
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42. Integrated approach for noncommunicable disease management in the Americas.

Author

Luciani, Silvana, Agurto, Irene, Holder, Reynaldo, Caixeta, Roberta, and Hennis, Anselm J. M.

Subjects
*DISEASE management, *MEDICAL care, *GLYCEMIC control, *NON-communicable diseases, *HYPERTENSION in women, *INTEGRATED health care delivery
Abstract

An overview of an integrated approach to improve noncommunicable disease (NCD) management is presented, along with tools on integrating NCD management as part of health system strengthening in the Americas. The study is based on an analysis of Pan American Health Organization/World Health Organization (PAHO/WHO) data and publicly available information on NCD care and capacity, disruptions in NCD services, and guidance on NCD management. Gaps in NCD care are highlighted, in which an estimated 43.0% of men and 28.0% of women with hypertension in Latin America remain undiagnosed; and for those with diabetes, 32.8% in Central and South America are undiagnosed. Yet, only 17/35 countries (49%) in the Americas report having evidence-based national guidelines for NCD management through a primary care approach and only 7/35 countries (20%) report provision of drug therapy, including glycaemic control for eligible persons. To improve NCD management, an integrated approach is needed to coordinate and deliver care across the levels of the health system. This includes increasing primary care capacity and competencies to address multiple chronic conditions, and integration with other complementary programs to avoid missing opportunities for NCD diagnosis and management. An integrated approach to NCD management, and implementation of available tools, should be part of rebuilding health systems after the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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