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6. Stroke Care during the COVID-19 Pandemic: International Expert Panel Review.

Author

Venketasubramanian, Narayanaswamy, Anderson, Craig, Ay, Hakan, Aybek, Selma, Brinjikji, Waleed, de Freitas, Gabriel, Del Brutto, Oscar, Fassbender, Klaus, Fujimura, Miki, Goldstein, Larry, Haberl, Roman, Hankey, Graeme, Heiss, Wolf-Dieter, Lestro Henriques, Isabel, Kase, Carlos, Kim, Jong, Koga, Masatoshi, Kokubo, Yoshihiro, Kuroda, Satoshi, Lee, Kiwon, Lee, Tsong-Hai, Liebeskind, David, Lip, Gregory, Meairs, Stephen, Medvedev, Roman, Mehndiratta, Man, Mohr, Jay, Nagayama, Masao, Pantoni, Leonardo, Papanagiotou, Panagiotis, Parrilla, Guillermo, Pastori, Daniele, Pendlebury, Sarah, Pettigrew, Luther, Renjen, Pushpendra, Rundek, Tatjana, Schminke, Ulf, Shinohara, Yukito, Tang, Wai, Toyoda, Kazunori, Wartenberg, Katja, Wasay, Mohammad, and Hennerici, Michael

Subjects
Coronavirus disease 2019, Management, Review, Stroke, Angiotensin Receptor Antagonists, COVID-19, Heparin, Low-Molecular-Weight, Humans, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Stroke
Abstract

BACKGROUND: Coronavirus disease 2019 (COVID-19) has placed a tremendous strain on healthcare services. This study, prepared by a large international panel of stroke experts, assesses the rapidly growing research and personal experience with COVID-19 stroke and offers recommendations for stroke management in this challenging new setting: modifications needed for prehospital emergency rescue and hyperacute care; inpatient intensive or stroke units; posthospitalization rehabilitation; follow-up including at-risk family and community; and multispecialty departmental developments in the allied professions. SUMMARY: The severe acute respiratory syndrome coronavirus 2 uses spike proteins binding to tissue angiotensin-converting enzyme (ACE)-2 receptors, most often through the respiratory system by virus inhalation and thence to other susceptible organ systems, leading to COVID-19. Clinicians facing the many etiologies for stroke have been sobered by the unusual incidence of combined etiologies and presentations, prominent among them are vasculitis, cardiomyopathy, hypercoagulable state, and endothelial dysfunction. International standards of acute stroke management remain in force, but COVID-19 adds the burdens of personal protections for the patient, rescue, and hospital staff and for some even into the postdischarge phase. For pending COVID-19 determination and also for those shown to be COVID-19 affected, strict infection control is needed at all times to reduce spread of infection and to protect healthcare staff, using the wealth of well-described methods. For COVID-19 patients with stroke, thrombolysis and thrombectomy should be continued, and the usual early management of hypertension applies, save that recent work suggests continuing ACE inhibitors and ARBs. Prothrombotic states, some acute and severe, encourage prophylactic LMWH unless bleeding risk is high. COVID-19-related cardiomyopathy adds risk of cardioembolic stroke, where heparin or warfarin may be preferable, with experience accumulating with DOACs. As ever, arteritis can prove a difficult diagnosis, especially if not obvious on the acute angiogram done for clot extraction. This field is under rapid development and may generate management recommendations which are as yet unsettled, even undiscovered. Beyond the acute management phase, COVID-19-related stroke also forces rehabilitation services to use protective precautions. As with all stroke patients, health workers should be aware of symptoms of depression, anxiety, insomnia, and/or distress developing in their patients and caregivers. Postdischarge outpatient care currently includes continued secondary prevention measures. Although hoping a COVID-19 stroke patient can be considered cured of the virus, those concerned for contact safety can take comfort in the increasing use of telemedicine, which is itself a growing source of patient-physician contacts. Many online resources are available to patients and physicians. Like prior challenges, stroke care teams will also overcome this one. Key Messages: Evidence-based stroke management should continue to be provided throughout the patient care journey, while strict infection control measures are enforced.

Published
2021

14. A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants

Author

Marano, Roberto B.M., Fernandes, Telma, Manaia, Célia M., Nunes, Olga, Morrison, Donald, Berendonk, Thomas U., Kreuzinger, Norbert, Tenson, Tanel, Corno, Gianluca, Fatta-Kassinos, Despo, Merlin, Christophe, Topp, Edward, Jurkevitch, Edouard, Henn, Leonie, Scott, Andrew, Heß, Stefanie, Slipko, Katarzyna, Laht, Mailis, Kisand, Veljo, Di Cesare, Andrea, Karaolia, Popi, Michael, Stella G., Petre, Alice L., Rosal, Roberto, Pruden, Amy, Riquelme, Virginia, Agüera, Ana, Esteban, Belen, Luczkiewicz, Aneta, Kalinowska, Agnieszka, Leonard, Anne, Gaze, William H., Adegoke, Anthony A., Stenstrom, Thor A., Pollice, Alfieri, Salerno, Carlo, Schwermer, Carsten U., Krzeminski, Pawel, Guilloteau, Hélène, Donner, Erica, Drigo, Barbara, Libralato, Giovanni, Guida, Marco, Bürgmann, Helmut, Beck, Karin, Garelick, Hemda, Tacão, Marta, Henriques, Isabel, Martínez-Alcalá, Isabel, Guillén-Navarro, Jose M., Popowska, Magdalena, Piotrowska, Marta, Quintela-Baluja, Marcos, Bunce, Joshua T., Polo-López, Maria I., Nahim–Granados, Samira, Pons, Marie-Noëlle, Milakovic, Milena, Udikovic-Kolic, Nikolina, Ory, Jérôme, Ousmane, Traore, Caballero, Pilar, Oliver, Antoni, Rodriguez-Mozaz, Sara, Balcazar, Jose L., Jäger, Thomas, Schwartz, Thomas, Yang, Ying, Zou, Shichun, Lee, Yunho, Yoon, Younggun, Herzog, Bastian, Mayrhofer, Heidrun, Prakash, Om, Nimonkar, Yogesh, Heath, Ester, Baraniak, Anna, Abreu-Silva, Joana, Choudhury, Manika, Munoz, Leonardo P., Krizanovic, Stela, Brunetti, Gianluca, Maile-Moskowitz, Ayella, Brown, Connor, and Cytryn, Eddie

Published
2020
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18. List of Contributors

Author

Aguilera, Ángeles, primary, Alhasawi, Azhar, additional, Amaro, Francisco, additional, Appanna, Varun, additional, Appanna, Vasu, additional, Baraúna, Rafael A., additional, Bazzicalupo, Marco, additional, Behera, Pratiksha, additional, Bhadury, Punyasloke, additional, Bharagava, Ram N., additional, Bhattacharyya, Maitree, additional, Bisht, Satpal S., additional, Brown, Damon, additional, Cameron, Karen, additional, Capes, Melinda D., additional, Chatterjee, Shruti, additional, Checcucci, Alice, additional, Danquah, Michael K., additional, DasSarma, Priya, additional, DasSarma, Shiladitya, additional, de Francisco, Patricia, additional, De Mandal, Surajit, additional, de Souza, Yuri Pinheiro Alves, additional, Demeter, Marc, additional, Desai, Chirayu, additional, Dhakar, Kusum, additional, Díaz, Silvia, additional, diCenzo, George C., additional, dos Santos, Lays T., additional, Furtak, Karolina, additional, Gałązka, Anna, additional, Genuário, Diego B., additional, Ghosh, Anwesha, additional, Gillet, Sébastien, additional, González-Toril, Elena, additional, Govil, Tanvi, additional, Gupta, Abhishek, additional, Gupta, Bhumika, additional, Gupta, Sanjay, additional, Gutiérrez, Juan-Carlos, additional, Henriques, Isabel, additional, Jagadeesan, Sasikumar, additional, Jain, Kunal, additional, Joshi, Amaraja, additional, Junge, Karen, additional, Kavamura, Vanessa N., additional, Kazy, Sufia K., additional, Khan, Atif, additional, Kulkarni, Snehal, additional, Kumar, N. Senthil, additional, Kumari, Khushbu, additional, Lawarée, Emeline, additional, Legendre, Félix, additional, Madamwar, Datta, additional, Martín-González, Ana, additional, Matroule, Jean-Yves, additional, Melo, Itamar S., additional, Mengoni, Alessio, additional, Mishra, Avinash, additional, Mishra, Samir R., additional, Mohapatra, Madhusmita, additional, Mulla, Sikandar I., additional, Nayak, Tanmaya, additional, Nema, Vijay, additional, Nunn, Brook, additional, Pal, Siddhartha, additional, Panda, Amrita K., additional, Panda, Ananta N., additional, Panigrahi, Satyanarayan, additional, Perrin, Elena, additional, Pinheiro, Juliana C., additional, Pramanik, Arnab, additional, Purchase, Diane, additional, Raina, Vishakha, additional, Rao, Toleti Subba, additional, Rastogi, Gurdeep, additional, Rathinam, Navanietha K., additional, Raval, Ishan H., additional, Ray, Lopamudra, additional, Rosado, Alexandre Soares, additional, Roy, Ajoy, additional, Salem, David R., additional, Sani, Rajesh K., additional, Santos, Suikinai N., additional, Sar, Pinaki, additional, Sarethy, Indira P., additional, Sarkar, Jayeeta, additional, Sarkar, Keka, additional, Saxena, Gaurav, additional, Sen, Samya, additional, Sengupta, Sohan, additional, Sharma, Shilpi, additional, Silva, Artur, additional, Singh, Prachi, additional, Srivastava, Nidhi, additional, Suar, Mrutyunjay, additional, Takami, Hideto, additional, Tewari, Sakshi, additional, Tiwari, Onkar, additional, Turner, Raymond J., additional, Vaz, Marcelo G.M.V., additional, Velraj, Parthiban, additional, Wolińska, Agnieszka, additional, and Yousuf, Basit, additional

Published
2019
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25. New insights into the role of constitutive bacterial rhizobiome and phenolic compounds in two Pinus spp. with contrasting susceptibility to pine pitch canker

Author

Leitão, Frederico, Pinto, Glória, Amaral, Joana, Monteiro, Pedro, Henriques, Isabel, Leitão, Frederico, Pinto, Glória, Amaral, Joana, Monteiro, Pedro, and Henriques, Isabel

Abstract

The rhizobiome is being increasingly acknowledged as a key player in plant health and breeding strategies. The pine pitch canker (PPC), caused by the fungus Fusarium circinatum, affects pine species with varying susceptibility degrees. Our aims were to explore the bacterial rhizobiome of a susceptible (Pinus radiata) and a resistant (Pinus pinea) species together with other physiological traits, and to analyze shifts upon F. circinatum inoculation. Pinus seedlings were stem inoculated with F. circinatum spores and needle gas exchange and antioxidant-related parameters were analyzed in non-inoculated and inoculated plants. Rhizobiome structure was evaluated through 16S rRNA gene massive parallel sequencing. Species (non-inoculated plants) harbored distinct rhizobiomes (<40% similarity), where P. pinea displayed a rhizobiome with increased abundance of taxa described in suppressive soils, displaying plant growth promoting (PGP) traits and/or anti-fungal activity. Plants of this species also displayed higher levels of phenolic compounds. F. circinatum induced slight changes in the rhizobiome of both species and a negative impact in photosynthetic-related parameters in P. radiata. We concluded that the rhizobiome of each pine species is distinct and higher abundance of bacterial taxa associated to disease protection was registered for the PPC-resistant species. Furthermore, differences in the rhizobiome are paralleled by a distinct content in phenolic compounds, which are also linked to plants’ resistance against PPC. This study unveils a species-specific rhizobiome and provides insights to exploit the rhizobiome for plant selection in nurseries and for rhizobiome-based plant-growth-promoting strategies, boosting environmentally friendly disease control strategies.

Published
2022

26. Microbial Associations of Abyssal Gorgonians and Anemones (>4,000 m Depth) at the Clarion-Clipperton Fracture Zone

Author

Quintanilla, Elena, Rodrigues, Clara F., Henriques, Isabel, Hilário, Ana, Quintanilla, Elena, Rodrigues, Clara F., Henriques, Isabel, and Hilário, Ana

Abstract

Deep coral-dominated communities play paramount roles in benthic environments by increasing their complexity and biodiversity. Coral-associated microbes are crucial to maintain fitness and homeostasis at the holobiont level. However, deep-sea coral biology and their associated microbiomes remain largely understudied, and less from remote and abyssal environments such as those in the Clarion-Clipperton Fracture Zone (CCZ) in the tropical Northeast (NE) Pacific Ocean. Here, we study microbial-associated communities of abyssal gorgonian corals and anemones (>4,000 m depth) in the CCZ; an area harboring the largest known global reserve of polymetallic nodules that are commercially interesting for the deep-sea nodule mining. Coral samples (n = 25) belonged to Isididae and Primnoidae families, while anemones (n = 4) to Actinostolidae family. Significant differences in bacterial community compositions were obtained between these three families, despite sharing similar habitats. Anemones harbored bacterial microbiomes composed mainly of Hyphomicrobiaceae, Parvibaculales, and Pelagibius members. Core microbiomes of corals were mainly dominated by different Spongiibacteraceae and Terasakiellaceae bacterial members, depending on corals’ taxonomy. Moreover, the predicted functional profiling suggests that deep-sea corals harbor bacterial communities that allow obtaining additional energy due to the scarce availability of nutrients. This study presents the first report of microbiomes associated with abyssal gorgonians and anemones and will serve as baseline data and crucial insights to evaluate and provide guidance on the impacts of deep-sea mining on these key abyssal communities.

Published
2022
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34. Additional file 2 of Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?

Author

Rocha, Jaqueline, Ferreira, Catarina, Mil-Homens, Dalila, Busquets, Antonio, Fialho, Ars��nio M., Henriques, Isabel, Gomila, Margarita, and Manaia, C��lia M.

Abstract

Additional file 2. Figure S1. Genetic environment of tellurium (ter) resistance-related genes. Blue arrows indicate the genes related to tellurium resistance and yellow arrows refer to hypothetical proteins; Figure S2. Genetic environment of arsenic (ars), copper (pco) and silver (sil) resistance-related genes. Blue arrows indicate genes related to resistance to arsenic, copper and arsenic metals, yellow arrows refer to hypothetical proteins; Figure S3. Genetic context of mercury (mer) resistance-related genes. Blue arrows indicate the genes related to mercury resistance and yellow arrows refer to hypothetical proteins; Figure S4. Genetic environment of yersiniabactin virulence locus. Blue arrows indicate genes related to yersiniabactin virulence and yellow arrows refer to hypothetical proteins.

Published
2022
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35. Mcr-1 and [bla.sub.KPC_3] in Escherichia coli sequence Type 744 after meropenem and colistin therapy, Portugal

Author

Tacao, Marta, Tavares, Rafael dos Santos, Teixeira, Pedro, Roxo, Ines, Ramalheira, Elmano, Ferreira, Sonia, and Henriques, Isabel

Subjects
Pneumonia -- Drug therapy -- Genetic aspects, Escherichia coli -- Genetic aspects -- Research, Meropenem -- Dosage and administration, Health
Abstract

The emergence of the mcr-1 gene (1) and reports on its global dissemination (2) unveiled the danger of plasmid-associated colistin resistance. In July 2016, a 70-yearold woman was admitted to [...]

Published
2017

41. Report and Comparative Genomics of an NDM-5-Producing Escherichia coli in a Portuguese Hospital: Complex Class 1 Integrons as Important Players in bla NDM Spread.

Author

Tavares, Rafael D. S., Tacão, Marta, Ramalheira, Elmano, Ferreira, Sónia, and Henriques, Isabel

Subjects
INTEGRONS, COMPARATIVE genomics, HORIZONTAL gene transfer, ESCHERICHIA coli, GENOMICS, DISEASE resistance of plants
Abstract

Background: New Delhi metallo-beta-lactamase (NDM) has been spreading across the globe, but the causes of its success are poorly understood. We characterized a blaNDM-5-positive Escherichia coli strain from a Portuguese hospital and conducted comparative genomic analyses to understand the role of clonal background and horizontal gene transfer in blaNDM-5 dissemination. Methods: After blaNDM PCR screening and genome sequencing, Ec355340 was subjected to mating, transformation, and plasmid curing assays and MICs determination for several antibiotics. Comparison with data compiled from public databases was performed. Results: blaNDM-5 was in a complex integron co-located in a FIB-FII plasmid (pEc355340_NDM-5). The mating assays were unsuccessful, but plasmid transformation into a susceptible host led to resistance to all beta-lactams and to sulfamethoxazole-trimethoprim. The profile of virulence genes (n = 73) was compatible with extraintestinal pathogenesis. An analysis of genomes from public databases suggested that blaNDM-5 has rarely been associated with ST156 strains (such as Ec355340), while is has frequently been found on strains of the ST10 clonal complex. However, ST156 may play a role in the co-spreading of blaNDM and mcr genes. Regardless, comparative genomics confirmed the presence of blaNDM in similar complex integrons in plasmids (48/100 plasmids most similar to pEc355340_NDM-5) and ST156 genomes (20/41 blaNDM-positive genomes). Conclusions: blaNDM-5 and other blaNDM variants were more frequently associated to complex integrons than previously reported and, therefore, these platforms may be important drivers in their dissemination. The identification of blaNDM-5 for the first time in Portugal could be a game-changer in the current Portuguese antibiotic resistance scenario, as this gene encodes a higher-level resistance phenotype, and its spread may be facilitated due to the association with complex integrons. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Gut and faecal bacterial community of the terrestrial isopod Porcellionides pruinosus: potential use for monitoring exposure scenarios

Author

Oliveira, Jacinta M.M., Henriques, Isabel, Read, Daniel S., Gweon, Hyun S., Morgado, Rui G., Peixoto, Sara, Correia, António, Soares, Amadeu M.V.M., Loureiro, Susana, Oliveira, Jacinta M.M., Henriques, Isabel, Read, Daniel S., Gweon, Hyun S., Morgado, Rui G., Peixoto, Sara, Correia, António, Soares, Amadeu M.V.M., and Loureiro, Susana

Abstract

This work aimed to characterize the gut and faeces bacterial communities (BC) of Porcellionides pruinosus using high-throughput sequencing. Isopods were collected from the field and kept in laboratory conditions similar to those normally applied in ecotoxicology tests. Faeces and purged guts of isopods (n = 3 × 30) were analysed by pyrosequencing the V3-V4 region of 16 S rRNA encoding gene. Results showed that gut and faecal BCs were dominated by Proteobacteria, particularly by an OTU (Operational Taxonomic Unit) affiliated to genus Coxiella. Diversity and richness values were statistically higher for faecal BC, mainly due to the occurrence of several low-abundance phylotypes. These results may reflect faecal carriage of bacterial groups that cannot settle in the gut. BCs of P. pruinosus comprised: (1) common members of the soil microbiota, (2) bacterial symbionts, (3) bacteria related to host metabolic/ecological features, and (4) bacterial etiological agents. Comparison of BC of this isopod species with the BC from other invertebrates revealed common bacterial groups across taxa. The baseline information provided by this work will assist the design and data interpretation of future ecotoxicological or biomonitoring assays where the analysis of P. pruinosus BC should be included as an additional indicator.

Published
2021

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