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3. Safety and efficacy of arimoclomol for inclusion body myositis: a multicentre, randomised, double-blind, placebo-controlled trial

Author

Dimachkie, Mazen, Statland, Jeffrey, Pasnoor, Mamatha, Jawdat, Omar, Heim, Andrew, Ciersdorff, Ali, Sasidharan, Sandhya, Currence, Melissa, Levine, Todd, Otutoa, Rebecca, Cooper, Angelina, Mozaffar, Tahseen, Habib, Ali, Cauchi, Jonathan, Ung, Shannon, Mathew, Veena, Hernandez, Isela, Gibson, Summer, Bromberg, Mark, Mahoney, Kyle, Neate, Crystal, Janecki, Teresa, Papadakis, Mike, Freimer, Miriam, Kaschalk, MacKenzie, Heintzman, Sarah, Wicklund, Matthew, Baines, Brenna, Vareldzis, Alexa, Hyslop, Emily, Blume, Brianna, Ciafaloni, Emma, Luebbe, Elizabeth, Eichinger, Katy, Martens, William, Gregory, Stephanie, Janciuras, Joanne, Amato, Anthony, Doughty, Christopher, Roe, Kristen, Flynn, Patricia, Russo, Emily, Lloyd, Thomas, Albayda, Jemima, Tiniakou, Eleni, Thomas, Simone, Jones, Sarah, Solorzano, Guillermo, Elliott, Matthew, Burns, Ted, Crowell, Allison, Eggleston, Deborah, Wagoner, Mary, Shaibani, Aziz, Oates, Chantae, Machado, Pedro, Hanna, Michael, Greensmith, Linda, Ahmed, Mhoriam, Vivekanandam, Vinojini, Appleby, Matthew, Ransley, George, Eshun, Edwin Eshun, Skorupinska, Iwona, Germain, Louise, Laxa, Ana Marie, Pontes, Joana Roca, Bellin, Anna, Anifowoshe, Dolapo, Machado, Pedro M, McDermott, Michael P, Blaettler, Thomas, Sundgreen, Claus, Amato, Anthony A, Gibson, Summer B, Jones, Sarah M, Levine, Todd D, Lloyd, Thomas E, Shaibani, Aziz I, Rosholm, Anders, Carstensen, Tim Dehli, Bonefeld, Karen, Jørgensen, Anders Nørkær, Phonekeo, Karina, Heim, Andrew J, Herbelin, Laura, Barohn, Richard J, Hanna, Michael G, and Dimachkie, Mazen M

Published
2023
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4. Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial

Author

Thornton, Charles A, Moxley, Richard Thomas, III, Eichinger, Katy, Heatwole, Chad, Mignon, Laurence, Arnold, W David, Ashizawa, Tetsuo, Day, John W, Dent, Gersham, Tanner, Matthew K, Duong, Tina, Greene, Ericka P, Herbelin, Laura, Johnson, Nicholas E, King, Wendy, Kissel, John T, Leung, Doris G, Lott, Donovan J, Norris, Daniel A, Pucillo, Evan M, Schell, Wendy, Statland, Jeffrey M, Stinson, Nikia, Subramony, Sub H, Xia, Shuting, Bishop, Kathie M, and Bennett, C Frank

Published
2023
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5. Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial

Author

Statland, Jeffrey M, Moore, Dan, Wang, Yunxia, Walsh, Maureen, Mozaffar, Tahseen, Elman, Lauren, Nations, Sharon P, Mitsumoto, Hiroshi, Fernandes, J Americo, Saperstein, David, Hayat, Ghazala, Herbelin, Laura, Karam, Chafic, Katz, Jonathan, Wilkins, Heather M, Agbas, Abdulbaki, Swerdlow, Russell H, Santella, Regina M, Dimachkie, Mazen M, Barohn, Richard J, and Consortium, The Rasagiline Investigators of the Muscle Study Group and Western ALS

Subjects
Clinical Research, Clinical Trials and Supportive Activities, ALS, Neurodegenerative, Neurosciences, Brain Disorders, Rare Diseases, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Neurological, Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, DNA-Binding Proteins, Double-Blind Method, Female, Humans, Indans, Male, Middle Aged, Neuroprotective Agents, Outcome Assessment, Health Care, Quality of Life, Retrospective Studies, Severity of Illness Index, Treatment Outcome, United States, Young Adult, amyotrophic lateral sclerosis, biomarker, MAO-B inhibitor, motor neuron disease, randomized, controlled clinical trial, rasagiline, Rasagiline Investigators of the Muscle Study Group and Western ALS Consortium, Medical and Health Sciences, Neurology & Neurosurgery
Abstract

Rasagiline is a monoamine oxidase B (MAO-B) inhibitor with possible neuroprotective effects in patients with amyotrophic lateral sclerosis (ALS). We performed a randomized, double-blind, placebo-controlled trial of 80 ALS participants with enrichment of the placebo group with historical controls (n = 177) at 10 centers in the United States. Participants were randomized in a 3:1 ratio to 2 mg/day rasagiline or placebo. The primary outcome was average slope of decline on the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary measures included slow vital capacity, survival, mitochondrial and molecular biomarkers, and adverse-event reporting. There was no difference in the average 12-month ALSFRS-R slope between rasagiline and the mixed placebo and historical control cohorts. Rasagiline did not show signs of drug-target engagement in urine and blood biomarkers. Rasagiline was well tolerated with no serious adverse events. Rasagiline did not alter disease progression compared with controls over 12 months of treatment. Muscle Nerve 59:201-207, 2019.

Published
2019

6. A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis.

Author

Pasnoor, Mamatha, He, Jianghua, Herbelin, Laura, Burns, Ted M, Nations, Sharon, Bril, Vera, Wang, Annabel K, Elsheikh, Bakri H, Kissel, John T, Saperstein, David, Shaibani, J Aziz, Jackson, Carlayne, Swenson, Andrea, Howard, James F, Goyal, Namita, David, William, Wicklund, Matthew, Pulley, Michael, Becker, Mara, Mozaffar, Tahseen, Benatar, Michael, Pazcuzzi, Robert, Simpson, Ericka, Rosenfeld, Jeffrey, Dimachkie, Mazen M, Statland, Jeffrey M, Barohn, Richard J, and Methotrexate in MG Investigators of the Muscle Study Group

Subjects
Methotrexate in MG Investigators of the Muscle Study Group, Humans, Myasthenia Gravis, Methotrexate, Prednisone, Receptors, Cholinergic, Immunosuppressive Agents, Autoantibodies, Treatment Outcome, Severity of Illness Index, Area Under Curve, Double-Blind Method, Adult, Aged, Aged, 80 and over, Middle Aged, Canada, United States, Female, Male, Clinical Trials and Supportive Activities, Rare Diseases, Autoimmune Disease, Neurosciences, Clinical Research, Orphan Drug, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveTo determine the steroid-sparing effect of methotrexate (MTX) in patients with symptomatic generalized myasthenia gravis (MG).MethodsWe performed a 12-month multicenter, randomized, double-blind, placebo-controlled trial of MTX 20 mg orally every week vs placebo in 50 acetylcholine receptor antibody-positive patients with MG between April 2009 and August 2014. The primary outcome measure was the prednisone area under the dose-time curve (AUDTC) from months 4 to 12. Secondary outcome measures included 12-month changes of the Quantitative Myasthenia Gravis Score, the Myasthenia Gravis Composite Score, Manual Muscle Testing, the Myasthenia Gravis Quality of Life, and the Myasthenia Gravis Activities of Daily Living.ResultsFifty-eight patients were screened and 50 enrolled. MTX did not reduce the month 4-12 prednisone AUDTC when compared to placebo (difference MTX - placebo: -488.0 mg, 95% confidence interval -2,443.4 to 1,467.3, p = 0.26); however, the average daily prednisone dose decreased in both groups. MTX did not improve secondary measures of MG compared to placebo over 12 months. Eight participants withdrew during the course of the study (1 MTX, 7 placebo). There were no serious MTX-related adverse events. The most common adverse event was nonspecific pain (19%).ConclusionsWe found no steroid-sparing benefit of MTX in MG over 12 months of treatment, despite being well-tolerated. This study demonstrates the challenges of conducting clinical trials in MG, including difficulties with recruitment, participants improving on prednisone alone, and the need for a better understanding of outcome measure variability for future clinical trials.Classification of evidenceThis study provides Class I evidence that for patients with generalized MG MTX does not significantly reduce the prednisone AUDTC over 12 months of therapy.

Published
2016

7. Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study

Author

Mazia, Claudio Gabriel, Wilken, Miguel, Barroso, Fabio, Saba, Juliet, Rugiero, Marcelo, Bettini, Mariela, Chaves, Marcelo, Vidal, Gonzalo, Garcia, Alejandra Dalila, De Bleecker, Jan, Van den Abeele, Guy, de Koning, Kathy, De Mey, Katrien, Mercelis, Rudy, Mahieu, Délphine, Wagemaekers, Linda, Van Damme, Philip, Depreitere, Annelies, Schotte, Caroline, Smetcoren, Charlotte, Stevens, Olivier, Van Daele, Sien, Vandenbussche, Nicolas, Vanhee, Annelies, Verjans, Sarah, Vynckier, Jan, D'Hondt, Ann, Tilkin, Petra, Alves de Siqueira Carvalho, Alzira, Dias Brockhausen, Igor, Feder, David, Ambrosio, Daniel, César, Pamela, Melo, Ana Paula, Martins Ribeiro, Renata, Rocha, Rosana, Bezerra Rosa, Bruno, Veiga, Thabata, da Silva, Luiz Augusto, Santos Engel, Murilo, Gonçalves Geraldo, Jordana, Ananias Morita, Maria da Penha, Nogueira Coelho, Erica, Paiva, Gabriel, Pozo, Marina, Prando, Natalia, Martineli Torres, Debora Dada, Butinhao, Cristiani Fernanda, Duran, Gustavo, Gomes da Silva, Tamires Cristina, Otavio Maia Gonçalves, Luiz, Pazetto, Lucas Eduardo, Fialho, Tomás Augusto Suriane, Renata Cubas Volpe, Luciana, Souza Duca, Luciana, Souza Bulle Oliveira, Acary, Amaral Andrade, Ana Carolina, Annes, Marcelo, Duarte Silva, Liene, Cavalcante Lino, Valeria, Pinto, Wladimir, Assis, Natália, Carrara, Fernanda, Miranda, Carolina, Souza, Iandra, Fernandes, Patricia, Siddiqi, Zaeem, Phan, Cecile, Narayan, Jeffrey, Blackmore, Derrick, Mallon, Ashley, Roderus, Rikki, Watt, Elizabeth, Junkerova, Jana, Kurkova, Barbora, Reguliova, Katarina, Zapletalova, Olga, Pitha, Jiri, Novakova, Iveta, Tyblova, Michaela, Jurajdova, Ivana, Wolfova, Marcela, Andersen, Henning, Harbo, Thomas, Vinge, Lotte, Krogh, Susanne, Mogensen, Anita, Vissing, John, Højgaard, Joan, Witting, Nanna, Mette Ostergaard Autzen, Anne, Pedersen, Jane, Eralinna, Juha-Pekka, Laaksonen, Mikko, Oksaranta, Olli, Harrison, Tuula, Eriksson, Jaana, Rozsa, Csilla, Horvath, Melinda, Lovas, Gabor, Matolcsi, Judit, Szabo, Gyorgyi, Jakab, Gedeonne, Szabadosne, Brigitta, Antonini, Giovanni, Di Pasquale, Antonella, Garibaldi, Matteo, Morino, Stefania, Troili, Fernanda, Fionda, Laura, Filla, Allessandro, Costabile, Teresa, Marano, Enrico, Saccà, Francesco, Fasanaro, Angiola, Marsili, Angela, Puorro, Giorgia, Mantegazza, Renato, Antozzi, Carlo, Bonanno, Silvia, Camera, Giorgia, Locatelli, Alberta, Maggi, Lorenzo, Pasanisi, Maria, Campanella, Angela, Evoli, Amelia, Alboini, Paolo Emilio, D'Amato, Valentina, Iorio, Raffaele, Kanai, Tetsuya, Kawaguchi, Naoki, Mori, Masahiro, Kaneko, Yoko, Kanzaki, Akiko, Kobayashi, Eri, Masaki, Katsuhisa, Matsuse, Dai, Matsushita, Takuya, Uehara, Taira, Shimpo, Misa, Jingu, Maki, Kikutake, Keiko, Nakamura, Yumiko, Sano, Yoshiko, Nagane, Yuriko, Kamegamori, Ikuko, Tsuda, Tomoko, Fujii, Yuko, Futono, Kazumi, Ozawa, Yukiko, Mizugami, Aya, Saito, Yuka, Morikawa, Miyuki, Samukawa, Makoto, Kamakura, Sachiko, Miyawaki, Eriko, Mitazaki, Teiichiro, Motomura, Masakatsu, Mukaino, Akihiro, Yoshimura, Shunsuke, Asada, Shizuka, Yoshida, Seiko, Amamoto, Shoko, Kobashikawa, Tomomi, Koga, Megumi, Maeda, Yasuko, Takada, Kazumi, Takada, Mihoko, Tsurumaru, Masako, Yamashita, Yumi, Akiyama, Tetsuya, Narikawa, Koichi, Tano, Ohito, Tsukita, Kenichi, Kurihara, Rikako, Meguro, Fumie, Fukuda, Yusuke, Sato, Miwako, Funaka, Soichiro, Kawamura, Tomohiro, Makamori, Masayuki, Takahashi, Masanori, Taichi, Namie, Hasuike, Tomoya, Higuchi, Eriko, Kobayashi, Hisako, Osakada, Kaori, Tsuda, Emiko, Shimohama, Shun, Hayashi, Takashi, Hisahara, Shin, Kawamata, Jun, Murahara, Takashi, Saitoh, Masaki, Suzuki, Shuichiro, Yamamoto, Daisuke, Ishiyama, Yoko, Ishiyama, Naoko, Noshiro, Mayuko, Takeyama, Rumi, Uwasa, Kaori, Yasuda, Ikuko, van der Kooi, Anneke, de Visser, Marianne, Gibson, Tamar, Casasnovas, Carlos, Alberti Aguilo, Maria Antonia, Homedes-Pedret, Christian, Julia Palacios, Natalia, Diez Porras, Laura, Velez Santamaria, Valentina, Lazaro, Ana, Diez Tejedor, Exuperio, Gomez Salcedo, Pilar, Fernandez-Fournier, Mireya, Lopez Ruiz, Pedro, Rodriguez de Rivera, Francisco Javier, Sastre, Maria, Gamez, Josep, Sune, Pilar, Salvado, Maria, Gili, Gisela, Mazuela, Gonzalo, Illa, Isabel, Cortes Vicente, Elena, Diaz-Manera, Jordi, Querol Gutierrez, Luis Antonio, Rojas Garcia, Ricardo, Vidal, Nuria, Arribas-Ibar, Elisabet, Piehl, Fredrik, Hietala, Albert, Bjarbo, Lena, Sengun, Ihsan, Meherremova, Arzu, Ozcelik, Pinar, Balkan, Bengu, Tuga, Celal, Ugur, Muzeyyen, Erdem-Ozdamar, Sevim, Bekircan-Kurt, Can Ebru, Acar, Nazire Pinar, Yilmaz, Ezgi, Caliskan, Yagmur, Orsel, Gulsah, Efendi, Husnu, Aydinlik, Seda, Cavus, Hakan, Kutlu, Ayse, Becerikli, Gulsah, Semiz, Cansu, Tun, Ozlem, Terzi, Murat, Dogan, Baki, Onar, Musa Kazim, Sen, Sedat, Kirbas Cavdar, Tugce, Veske, Adife, Norwood, Fiona, Dimitriou, Aikaterini, Gollogly, Jakit, Mahdi-Rogers, Mohamed, Seddigh, Arshira, Sokratous, Giannis, Maier, Gal, Sohail, Faisal, Jacob, Saiju, Sadalage, Girija, Torane, Pravin, Brown, Claire, Shah, Amna, Sathasivam, Sivakumar, Arndt, Heike, Davies, Debbie, Watling, Dave, Amato, Anthony, Cochrane, Thomas, Salajegheh, Mohammed, Roe, Kristen, Amato, Katherine, Toska, Shirli, Wolfe, Gil, Silvestri, Nicholas, Patrick, Kara, Zakalik, Karen, Katz, Jonathan, Miller, Robert, Engel, Marguerite, Forshew, Dallas, Bravver, Elena, Brooks, Benjamin, Plevka, Sarah, Burdette, Maryanne, Cunningham, Scott, Sanjak, Mohammad, Kramer, Megan, Nemeth, Joanne, Schommer, Clara, Tierney, Scott, Juel, Vern, Guptill, Jeffrey, Hobson-Webb, Lisa, Massey, Janice, Beck, Kate, Carnes, Donna, Loor, John, Anderson, Amanda, Pascuzzi, Robert, Bodkin, Cynthia, Kincaid, John, Snook, Riley, Guingrich, Sandra, Micheels, Angela, Chaudhry, Vinay, Corse, Andrea, Mosmiller, Betsy, Kelley, Andrea, Ho, Doreen, Srinivasan, Jayashri, Vytopil, Michal, Jara, Jordan, Ventura, Nicholas, Scala, Stephanie, Carter, Cynthia, Donahue, Craig, Herbert, Carol, Weiner, Elaine, Alam, Sharmeen, McKinnon, Jonathan, Haar, Laura, McKinnon, Naya, Alcon, Karan, McKenna, Kaitlyn, Sattar, Nadia, Daniels, Kevin, Jeffery, Dennis, Freimer, Miriam, Hoyle, Joseph Chad, Kissel, John, Agriesti, Julie, Chelnick, Sharon, Mezache, Louisa, Pineda, Colleen, Muharrem, Filiz, Karam, Chafic, Khoury, Julie, Marburger, Tessa, Kaur, Harpreet, Dimitrova, Diana, Gilchrist, James, Agrawal, Brajesh, Elsayed, Mona, Kohlrus, Stephanie, Andoin, Angela, Darnell, Taylor, Golden, Laura, Lokaitis, Barbara, Seelback, Jenna, Muppidi, Srikanth, Goyal, Neelam, Sakamuri, Sarada, So, Yuen T., Paulose, Shirley, Pol, Sabrina, Welsh, Lesly, Bhavaraju-Sanka, Ratna, Tobon Gonzales, Alejandro, Dishman, Lorraine, Jones, Floyd, Gonzalez, Anna, Padilla, Patricia, Saklad, Amy, Silva, Marcela, Kazamel, Mohamed, Alsharabati, Mohammad, Lu, Liang, Nozaki, Kenkichi, Mumfrey-Thomas, Sandi, Woodall, Amy, Mozaffar, Tahseen, Cash, Tiyonnoh, Goyal, Namita, Roy, Gulmohor, Mathew, Veena, Maqsood, Fatima, Minton, Brian, Jones, H. James, Rosenfeld, Jeffrey, Garcia, Rebekah, Echevarria, Laura, Garcia, Sonia, Pulley, Michael, Aranke, Shachie, Berger, Alan Ross, Shah, Jaimin, Shabbir, Yasmeen, Smith, Lisa, Varghese, Mary, Gutmann, Laurie, Gutmann, Ludwig, Jerath, Nivedita, Nance, Christopher, Swenson, Andrea, Olalde, Heena, Kressin, Nicole, Sieren, Jeri, Barohn, Richard, Dimachkie, Mazen, Glenn, Melanie, McVey, April, Pasnoor, Mamatha, Statland, Jeffery, Wang, Yunxia, Liu, Tina, Emmons, Kelley, Jenci, Nicole, Locheke, Jerry, Fondaw, Alex, Johns, Kathryn, Rico, Gabrielle, Walsh, Maureen, Herbelin, Laura, Hafer-Macko, Charlene, Kwan, Justin, Zilliox, Lindsay, Callison, Karen, Young, Valerie, DiSanzo, Beth, Naunton, Kerry, Benatar, Michael, Bilsker, Martin, Sharma, Khema, Cooley, Anne, Reyes, Eliana, Michon, Sara-Claude, Sheldon, Danielle, Steele, Julie, Howard Jr, James, Chopra, Manisha, Traub, Rebecca, Vu, Tuan, Katzin, Lara, McClain, Terry, Harvey, Brittany, Hart, Adam, Huynh, Kristin, Beydoun, Said, Chilingaryan, Amaiak, Doan, Victor, Droker, Brian, Gong, Hui, Karimi, Sanaz, Lin, Frank, Pokala, Krishna, Shah, Akshay, Tran, Anh, Akhter, Salma, Malekniazi, Ali, Tandan, Rup, Hehir, Michael, Waheed, Waqar, Lucy, Shannon, Weiss, Michael, Distad, Jane, Strom, Susan, Downing, Sharon, Kim, Bryan, Nowak, Richard, Dicapua, Daniel, Keung, Benison, Kumar, Aditya, Patwa, Huned, Robeson, Kimberly, Yang, Irene, Nye, Joan, Vu, Hong, Murai, Hiroyuki, Uzawa, Akiyuki, Suzuki, Yasushi, Imai, Tomihiro, Shiraishi, Hirokazu, Suzuki, Hidekazu, Okumura, Meinoshin, O’Brien, Fanny, Wang, Jing-Jing, Fujita, Kenji P., and Utsugisawa, Kimiaki

Published
2019
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8. Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

Author

Cutter, Gary, Aban, Inmaculada, Minisman, Greg, Feese, Michelle, Kuo, Hui-Chien, Newsom-Davis, John, Wolfe, Gil, Kaminski, Henry, Jaretzki, Alfred, Sonett, Joshua, Mazia, Claudio, Saluto, Valeria, Rosenberg, Moises, Alvarez, Valeria, Rey, Lisa, King, John, Butzkueven, Helmut, Goldblatt, John, Carey, John, Pollard, John, Reddel, Stephen, Handel, Nicholas, McCaughan, Brian, Pallot, Linda, Waddington-Cruz, Márcia, Novis, Ricardo, Boasquevisque, Carlos, Dias-Tosta, Elza, Morato-Fernandez, Rubens, Ximenes, Manoel, Werneck, Lineu, Scola, Rosana, Soltoski, Paulo, Chalk, Colin, Moore, Fraser, Mulder, David, Wadup, Lisa, Oger, Joel, Mezei, Michele, Evans, Kenneth, Jiwa, Theresa, Schaffar, Anne, White, Chris, Toth, Cory, Gelfand, Gary, Wood, Susan, Pringle, Elizabeth, Zwicker, Jocelyn, Maziak, Donna, Shamji, Farid, Sundaresan, Sudhir, Seely, Andrew, Cea, Gabriel, Verduga, Renato, Aguayo, Alberto, Jander, Sebastian, Zickler, Philipp, Klein, Michael, Marx, Alexander, Ströbel, Philipp, Weis, Cleo-Aron, Melms, Arthur, Bischof, Felix, Aebert, Hermann, Ziemer, Gerhard, Nix, Wilfred, Thümler, Björn, Wilhem-Schwenkmezger, Thomas, Mayer, Eckhard, Schalke, Berthold, Pöschel, Peter, Hieber, Gisela, Wiebe, Karsten, Antonini, Giovanni, Clemenzi, Alessandro, Ceschin, Vanessa, Rendina, Erino, Venuta, Federico, Morino, Stefania, Bucci, Elisabetta, Durelli, Luca, Tavella, Alessia, Clerico, Marinella, Contessa, Giulia, Borasio, Piero, Evoli, Amelia, Servidei, Serenella, Granone, Pierluigi, Mantegazza, Renato, Berta, Emilia, Novellino, Lorenzo, Spinelli, Luisa, Motomura, Masakatsu, Matsuo, Hidenori, Nagayasu, Takeshi, Yoshikawa, Hiroaki, Takamori, Masaharu, Oda, Makoto, Matsumoto, Isao, Furukawa, Yutaka, Noto, Daisuke, Motozaki, Yuko, Iwasa, Kazuo, Yanase, Daisuke, Garcia Ramos, Guillermo, Cacho, Bernardo, de la Garza, Lorenzo, Kostera-Pruszczyk, Anne, Lipowska, Marta, Kwiecinski, Hubert, Potulska-Chromik, Anna, Orlowski, Tadeusz, Silva, Ana, Feijo, Marta, Freitas, António, Heckmann, Jeannine, Frost, Andrew, Pan, Edward, Tucker, Lawrence, Rossouw, Johan, Drummond, Fiona, Illa, Isabel, Diaz, Jorge, Leon, Carlos, Yeh, Jiann-Horng, Chiu, Hou-Chang, Hsieh, Yei-San, Witoonpanich, Rawiphan, Tunlayadechanont, Supoch, Attanavanich, Sukasom, Verschuuren, Jan, Straathof, Chiara, Titulaer, Maarten, Versteegh, Michel, Pels, Arda, Krum, Yvonne, Buckley, Camilla, Leite, M. Isabel, Vincent, Angela, Hilton-Jones, David, Ratnatunga, Chandi, Farrugia, Maria, Petty, Richard, Overell, James, Kirk, Alan, Gibson, Andrew, McDermott, Chris, Hopkinson, David, Lecky, Bryan, Watling, David, Marshall, Dot, Saminaden, Sam, Davies, Deborah, Dougan, Charlotte, Sathasivam, Siva, Page, Richard, Sussman, Jon, Ealing, John, Krysiak, Peter, Amato, Anthony, Salajegheh, Mohammad, Jaklitsch, Michael, Roe, Kristen, Ashizawa, Tetsuo, Smith, Robert Glenn, Zwischenberg, Joseph, Stanton, Penny, Barboi, Alexandru, Jaradeh, Safwan, Tisol, William, Gasparri, Mario, Haasler, George, Yellick, Mary, Dennis, Cedric, Barohn, Richard, Pasnoor, Mamatha, Dimachkie, Mazen, McVey, April, Gronseth, Gary, Dick, Arthur, Kramer, Jeffrey, Currence, Melissa, Herbelin, Laura, Belsh, Jerry, Li, George, Langenfeld, John, Mertz, Mary Ann, Benatar, Michael, Harrison, Taylor, Force, Seth, Usher, Sharon, Beydoun, Said, Lin, Frank, DeMeester, Steve, Akhter, Salem, Malekniazi, Ali, Avenido, Gina, Crum, Brian, Milone, Margherita, Cassivi, Stephen, Fisher, Janet, Ciafaloni, Emma, Heatwole, Chad, Watson, Thomas, Hilbert, James, Smirnow, Alexis, Distad, B. Jane, Weiss, Michael, Wood, Douglas, Haug, Joanna, Ernstoff, Raina, Cao, Jingyang, Chmielewski, Gary, Welsh, Robert, Duris, Robin, Gutmann, Laurie, Pawar, Gauri, Graeber, Geoffrey Marc, Altemus, Patricia, Nance, Christopher, Gutmann, Ludwig, Jackson, Carlayne, Grogan, Patrick, Calhoon, John, Kittrell, Pamela, Myers, Deborah, Hayat, Ghazala, Naunheim, Keith, Eller, Susan, Holzemer, Eve, Katirji, Bashar, Alshekhlee, Amer, Robke, Jason, Karlinchak, Brenda, Katz, Jonathan, Miller, Robert, Roan, Ralph, Forshew, Dallas, Kissel, John, Elsheikh, Bakri, Ross, Patrick, Chelnick, Sharon, Lewis, Richard, Acsadi, Agnes, Baciewicz, Frank, Masse, Stacey, Massey, Janice, Juel, Vern, Onaitis, Mark, Lowe, James, Lipscomb, Bernadette, Mozaffar, Tahseen, Thai, Gaby, Milliken, Jeffrey, Martin, Veronica, Karayan, Ronnie, Muley, Suraj, Parry, Gareth, Shumway, Sara, Oh, Shin, Claussen, Gwen, Lu, Liang, Cerfolio, Robert, Young, Angela, Morgan, Marla, Pascuzzi, Robert, Kincaid, John, Kesler, Kenneth, Guingrich, Sandy, Michaels, Angi, Phillips, Lawrence, Burns, Ted, Jones, David, Fischer, Cindy, Pulley, Michael, Berger, Alan, D'Agostino, Harry, Smith, Lisa, Rivner, Michael, Pruitt, Jerry, Landolfo, Kevin, Hillman, Demetric, Shaibani, Aziz, Sermas, Angelo, Ruel, Ross, Ismail, Farah, Sivak, Mark, Goldstein, Martin, Camunas, Jorge, Bratton, Joan, Tandan, Rup, Panitch, Hill, Leavitt, Bruce, Jones, Marilee, Muppidi, Srikanth, Vernino, Steven, Nations, Sharon, Meyer, Dan, Gorham, Nina, Wolfe, Gil I, Kaminski, Henry J, Aban, Inmaculada B, Cea, J Gabriel, Heckmann, Jeannine M, King, John O, Beydoun, Said R, Chalk, Colin H, Barboi, Alexandru C, Amato, Anthony A, Shaibani, Aziz I, Lecky, Bryan R F, Pulley, Michael T, Rivner, Michael H, Kostera-Pruszczyk, Anna, Pascuzzi, Robert M, Jackson, Carlayne E, Verschuuren, Jan J G M, Massey, Janice M, Kissel, John T, Werneck, Lineu C, Barohn, Richard J, Silvestri, Nicholas J, Conwit, Robin, Sonett, Joshua R, Jaretzki, Alfred, III, and Cutter, Gary R

Published
2019
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9. Safety and efficacy of arimoclomol for inclusion body myositis: a multicentre, randomised, double-blind, placebo-controlled trial

Author

Machado, Pedro M, primary, McDermott, Michael P, additional, Blaettler, Thomas, additional, Sundgreen, Claus, additional, Amato, Anthony A, additional, Ciafaloni, Emma, additional, Freimer, Miriam, additional, Gibson, Summer B, additional, Jones, Sarah M, additional, Levine, Todd D, additional, Lloyd, Thomas E, additional, Mozaffar, Tahseen, additional, Shaibani, Aziz I, additional, Wicklund, Matthew, additional, Rosholm, Anders, additional, Carstensen, Tim Dehli, additional, Bonefeld, Karen, additional, Jørgensen, Anders Nørkær, additional, Phonekeo, Karina, additional, Heim, Andrew J, additional, Herbelin, Laura, additional, Barohn, Richard J, additional, Hanna, Michael G, additional, Dimachkie, Mazen M, additional, Dimachkie, Mazen, additional, Statland, Jeffrey, additional, Pasnoor, Mamatha, additional, Jawdat, Omar, additional, Heim, Andrew, additional, Ciersdorff, Ali, additional, Sasidharan, Sandhya, additional, Currence, Melissa, additional, Levine, Todd, additional, Otutoa, Rebecca, additional, Cooper, Angelina, additional, Habib, Ali, additional, Cauchi, Jonathan, additional, Ung, Shannon, additional, Mathew, Veena, additional, Hernandez, Isela, additional, Gibson, Summer, additional, Bromberg, Mark, additional, Mahoney, Kyle, additional, Neate, Crystal, additional, Janecki, Teresa, additional, Papadakis, Mike, additional, Kaschalk, MacKenzie, additional, Heintzman, Sarah, additional, Baines, Brenna, additional, Vareldzis, Alexa, additional, Hyslop, Emily, additional, Blume, Brianna, additional, Luebbe, Elizabeth, additional, Eichinger, Katy, additional, Martens, William, additional, Gregory, Stephanie, additional, Janciuras, Joanne, additional, Amato, Anthony, additional, Doughty, Christopher, additional, Roe, Kristen, additional, Flynn, Patricia, additional, Russo, Emily, additional, Lloyd, Thomas, additional, Albayda, Jemima, additional, Tiniakou, Eleni, additional, Thomas, Simone, additional, Jones, Sarah, additional, Solorzano, Guillermo, additional, Elliott, Matthew, additional, Burns, Ted, additional, Crowell, Allison, additional, Eggleston, Deborah, additional, Wagoner, Mary, additional, Shaibani, Aziz, additional, Oates, Chantae, additional, Machado, Pedro, additional, Hanna, Michael, additional, Greensmith, Linda, additional, Ahmed, Mhoriam, additional, Vivekanandam, Vinojini, additional, Appleby, Matthew, additional, Ransley, George, additional, Eshun, Edwin Eshun, additional, Skorupinska, Iwona, additional, Germain, Louise, additional, Laxa, Ana Marie, additional, Pontes, Joana Roca, additional, Bellin, Anna, additional, and Anifowoshe, Dolapo, additional

Published
2023
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10. Database Evaluation for Muscle and Nerve Diseases - DEMAND: An academic neuromuscular coding system

Author

Pasnoor, Mamatha, primary, Khan, Saud, additional, Jackson, Carlayne E., additional, Kissel, John, additional, Wolfe, Gil I., additional, Nations, Sharon P., additional, Trivedi, Jaya R., additional, Singer, Mike A., additional, Elliott, Jeffrey L., additional, Vernino, Steven, additional, Mummaneni, Reddiah Babu, additional, Herbelin, Laura, additional, Saperstein, David S., additional, Gronseth, Gary, additional, McVey, April L., additional, Dimachkie, Mazen M., additional, and Barohn, Richard J., additional

Published
2023
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11. Phase 2 trial in acetylcholine receptor antibody‐positive myasthenia gravis of transition from intravenous to subcutaneous immunoglobulin: The MGSCIg study

Author

Pasnoor, Mamatha, primary, Bril, Vera, additional, Levine, Todd, additional, Trivedi, Jaya, additional, Silvestri, Nicholas J., additional, Phadnis, Milind, additional, Katzberg, Hans D., additional, Saperstein, David S., additional, Wolfe, Gil I., additional, Herbelin, Laura, additional, Higgs, Kiley, additional, Heim, Andrew J., additional, Statland, Jeffrey M., additional, Barohn, Richard J., additional, and Dimachkie, Mazen M., additional

Published
2023
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15. Episodic Ataxia Type 1: Natural History and Effect on Quality of Life.

Author

Graves, Tracey D., Griggs, Robert C., Bundy, Brian N., Jen, Joanna C., Baloh, Robert W., Hanna, Michael G., the CINCH Investigators, Jen, Joanna J., Amato, Anthony A., Barohn, Richard J., Hahn, Angelika F., Hart, Kimberly, Herr, Barbara, Wang, Yunxia, Salajegheh, Mohammad, Puwanant, Araya, Rajakalendran, Sanjeev, Cha, Yoon-Hee, Krischer, Jeffrey, and Herbelin, Laura

Subjects
INTERACTIVE voice response (Telecommunication), NATURAL history, SPINOCEREBELLAR ataxia, CLUSTER headache, ATAXIA, QUALITY of life
Abstract

Episodic ataxia type 1 (EA1) is a rare autosomal potassium channelopathy, due to mutations in KCNA1. Patients have childhood onset of intermittent attacks of ataxia, dizziness or imbalance. In order to quantify the natural history of EA1, its effect on quality of life and in preparation for future clinical trials, we set up an international multi-centre study of EA1. We recruited thirty-three participants with EA1: twenty-three completed 1-year follow-up and eighteen completed 2-year follow-up. There was very little accumulation of disability or impairment over the course of the 2 years of the study. The outcome measures of ataxia (SARA and functional rating of ataxia) and the activities of daily living scale were largely stable over time. Self-reported health-related quality of life (SF-36) scores were lower across all domains than controls, in keeping with a chronic condition. Physical subdomain scores appeared to deteriorate over time, which seems to be driven by the female participants in the study. This is an interesting finding and warrants further study. Attacks of EA1 reported by participants in real time via an interactive voice response system showed that symptoms were not stereotyped; however, attack duration and frequency was stable between individuals. This large prospective study is the first ever completed in subjects with EA1. We document the natural history of the disorder over 2 years. These data will enable the development of outcome measures for clinical trials of treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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18. A Randomized, Double-Blind, Placebo-Controlled Study of Arimoclomol in Patients with Inclusion Body Myositis (S23.010)

Author

Machado, Pedro, primary, Barohn, Richard, additional, McDermott, Michael, additional, Blaetter, Thomas, additional, Lloyd, Thomas, additional, Shaibani, Aziz, additional, Freimer, Miriam, additional, Amato, Anthony, additional, Ciafaloni, Emma, additional, Jones, Sarah, additional, Mozaffar, Tahseen, additional, Gibson, Summer, additional, Wicklund, Matthew, additional, Levine, Todd, additional, Sundgreen, Claus, additional, Carstensen, Thomas, additional, Bonefeld, Karen, additional, J⊘rgensen, Anders N⊘rkær, additional, Phonekeo, Karina, additional, Heim, Andrew, additional, Herbelin, Laura, additional, Hanna, Michael, additional, and Dimachkie, Mazen, additional

Published
2022
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22. Safety of aerobic exercise in people with diabetic peripheral neuropathy: single-group clinical trial

Author

Kluding, Patricia M., Pasnoor, Mamatha, Singh, Rupali, D'Silva, Linda J., Yoo, Min, Billinger, Sandra A., LeMaster, Joseph W., Dimachkie, Mazen M., Herbelin, Laura, and Wright, Douglas E.

Subjects
Polyneuropathies -- Causes of -- Care and treatment -- Research, Aerobic exercises -- Health aspects -- Research, Type 2 diabetes -- Complications and side effects -- Care and treatment -- Research, Health
Abstract

Background. Exercise is recommended for people with diabetes, but little is known about exercise in people with diabetic peripheral neuropathy (DPN). Objective. The primary purpose of this preliminary study was to examine adverse events (AEs) during moderate-intensity, supervised aerobic exercise in people with DPN. The secondary purpose was to examine changes in fatigue, aerobic fitness, and other outcomes after intervention. Design. This was a single-group preliminary study. Setting. The setting was an academic medical center. Participants. Participants were 18 people who were sedentary and had type 2 diabetes and peripheral neuropathy (mean age=58.1 years, SD=5). Intervention. The intervention was a supervised 16-week aerobic exercise program (3 times per week at 50% to >70% oxygen uptake reserve). Measurements. Adverse events were categorized as related or unrelated to the study, anticipated or unanticipated, and serious or not serious. Outcomes included fatigue (Multidimensional Fatigue Inventory), cardiovascular fitness (peak oxygen uptake), body composition (dual-energy x-ray absorptiometry), sleep quality, plasma metabolic markers, and peripheral vascular function. Results. During the study, 57 nonserious AEs occurred. Improvements were found in general fatigue (mean change = -3.5; 95% confidence interval [95% CI] = -1.3, -5.3), physical fatigue (mean change = -3.1; 95% CI = -1.2, -5.0), peak oxygen uptake (mean change = 1.1 mL x [kg.sup.-1]-min 95% CI=0.2, 1.9), total body fat (mean change = -1%; 95% CI= -0.3, -1.7), fat mass (mean change= -1,780 g; 95% CI = -616.2, -2,938.7), and peripheral blood flow (mean change = 2.27%; 95% CI=0.6, 4.0). Limitations. This was a small-scale, uncontrolled study. A future randomized controlled trial is needed to fully assess the effects of exercise on the outcomes. Conclusions. This study provides new support for supervised aerobic exercise in people with DPN. However, it is important for physical therapists to carefully prescribe initial exercise intensity and provide close monitoring and education to address the anticipated AEs as people who are sedentary and have DPN begin an exercise program., Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes, with lower limb pain and sensory loss caused by slow peripheral nerve degeneration. The most common form [...]

Published
2015
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23. Phase II Study of Arimoclomol in IBM FDA-OOPD

Author

Dimachkie, Mazen M., primary, Hanna, Michael, additional, Machado, Pedro, additional, Herbelin, Laura, additional, Pasnoor, Mamatha, additional, Jawdat, Omar, additional, McVey, April, additional, Statland, Jeffery, additional, Glenn, Melanie D., additional, Greensmith, Linda, additional, Martens, Bill, additional, Tawil, Rabi, additional, McDermott, Michael, additional, and Barohn, Richard J., additional

Published
2021
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24. Abstracts from the ASENT 2008 Annual Meeting March 6–8, 2008

Author

VanDenburgh, Amanda, Shah, Manasee V., Hua, S., Abu-Shakra, S., Wagg, Jon, Khariton, Tatiana, Beddingfield, F. C., Brin, M. F., Herr, Barbara E., Hart, Kimberly A., McDermott, Michael, Griggs, Robert C., Herbelin, Laura, Barohn, Richard, Loane, David J., Byrnes, Kimberly R., Stoica, Bogdan A., Pajoohesh-Ganji, Ahdeah, Faden, Alan I., Nahab, Fatta, Wittevrongel, Loretta, Hallett, Mark, Li, Ingrid, Brady, Linda, Driscoll, Jamie, Guyer, Mark, Yao, Yong, Almeida, Luis, Maia, Joana, Soares-da-Silva, Patricio, Rocha, Jose Francisco, Lopes, Carlos, Nunes, Teresa, Machado, Rita, Costa, Raquel, Torrão, Leonel, Loureiro, Ana-Isabel, Vaz-da-Silva, Manuel, Wright, Lyndon, Falcão, Amilcar, Coelho, Rui, Albino-Teixeira, Antonio, Cusack, Noel, Hurtt, Mark, Katner, Simon, Torchia, John, Solomon, Bruce, Guinn, Robyn, Rohde, Candace, Thorne, Christine, Cusack, Noel J., Aungst, Bruce, Venkatarangan, Lata, Behrens, Davette, Brown, Foster, Meltzer, Peter, Bakshi, Rohit, Neema, Mohit, Healy, Brian C., Liptak, Zsuzsanna, Betensky, Rebecca A., Buckle, Guy J., Gauthier, Susan A., Stankiewicz, James, Meier, Dominik, Egorova, Svetlana, Arora, Ashish, Guss, Zachary D., Glanz, Bonnie I., Khoury, Samia J., Guttmann, Charles R. G., Weiner, Howard L., Guss, Jason G., and CINCH Study Group

Published
2008
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25. Books to Read Before You Graduate High School

Author

Barohn, Richard J., primary, Freeman, Joshua, additional, Kissel, John, additional, Wallis, Marc, additional, Katz, Jonathan, additional, Levine, Todd, additional, Saperstein, Dave, additional, Jawdat, Omar, additional, Barohn, Joel, additional, Ensrud, Erik R., additional, Gorson, Kenneth, additional, Herbelin, Laura, additional, Swerdlow, Russel, additional, Burns, Jeff, additional, Jackson, Carlayne, additional, and Dubinsky, Richard, additional

Published
2021
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30. A quantitative measure of handgrip myotonia in non-dystrophic myotonia

Author

Statland, Jeffrey M., Bundy, Brian N., Wang, Yunxia, Trivedi, Jaya R., Raja Rayan, Dipa, Herbelin, Laura, Donlan, Merideth, McLin, Rhonda, Eichinger, Katy J., Findlater, Karen, Dewar, Liz, Pandya, Shree, Martens, William B., Venance, Shannon L., Matthews, Emma, Amato, Anthony A., Hanna, Michael G., Griggs, Robert C., and Barohn, Richard J.

Published
2012
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34. Amyloid Myopathy as an Inclusion Body Myositis Mimic

Author

Heim, Andrew, primary, Hamasaki, Anai, additional, Dimachkie, Mazen, additional, Pasnoor, Mamatha, additional, Jawdat, Omar, additional, Statland, Jeffrey, additional, Jacobson, Ryan, additional, Distad, Barbara, additional, Weiss, Michael, additional, Glenn, Melanie, additional, Gallagher, Gary, additional, Camelo-Piragua, Sandra, additional, and Herbelin, Laura, additional

Published
2020
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35. Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS

Author

Benatar, Michael, primary, Zhang, Lanyu, additional, Wang, Lily, additional, Granit, Volkan, additional, Statland, Jeffrey, additional, Barohn, Richard, additional, Swenson, Andrea, additional, Ravits, John, additional, Jackson, Carlayne, additional, Burns, Ted M., additional, Trivedi, Jaya, additional, Pioro, Erik P., additional, Caress, James, additional, Katz, Jonathan, additional, McCauley, Jacob L., additional, Rademakers, Rosa, additional, Malaspina, Andrea, additional, Ostrow, Lyle W., additional, Wuu, Joanne, additional, Hussain, Sumaira, additional, Cooley, Anne, additional, Li, Yindi, additional, Wallace, Marielle, additional, Steele, Julie, additional, Hernandez, Jessica P, additional, Medina, Jessica, additional, Paredes, Maria Elena, additional, Manso, Ashley, additional, Ravelo, Natalia, additional, Levy, Wendy, additional, Whitehead, Patrice, additional, Zuchner, Stephan, additional, Pasnoor, Mamatha, additional, Jawdat, Omar, additional, Jabari, Duaa, additional, Farmakidis, Constantine, additional, Glenn, Melanie, additional, Dimachkie, Mazen M, additional, Herbelin, Laura, additional, Tanui, Hellen, additional, Anderson, Sherri, additional, Walker, Michaela, additional, Liu, Tina, additional, McCally, Ayla, additional, Heim, Andrew, additional, Currence, Melissa, additional, Harness, Yolanda, additional, Sieren, Jeri, additional, Gibson, Emilee, additional, Gutierrez, Gil, additional, Bussey, Danielle, additional, Previte, Rose, additional, Kittrell, Pamella, additional, Joshi, Amruta, additional, Conger, Amy, additional, Hastings, Debbie, additional, Caristo, Irys, additional, Marandi, Mozhdeh, additional, Carty, Simon, additional, Taylor, J Paul, additional, Wu, Gang, additional, Rampersaud, Evadnie, additional, Schule, Rebecca, additional, and Blitterswijk, Marka van, additional

Published
2020
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38. Magnetic resonance imaging correlates with electrical impedance myography in facioscapulohumeral muscular dystrophy

Author

Hamel, Johanna, primary, Lee, Phil, additional, Glenn, Melanie D., additional, Burka, Tekalign, additional, Choi, In‐Young, additional, Friedman, Seth D., additional, Shaw, Dennis W. W., additional, McCalley, Ayla, additional, Herbelin, Laura, additional, Dimachkie, Mazen M., additional, Lemmers, Richard, additional, Maarel, Silvère M., additional, Barohn, Richard J., additional, Tawil, Rabi, additional, and Statland, Jeffrey M., additional

Published
2020
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39. CLINICAL FINDINGS IN MUSK-ANTIBODY POSITIVE MYASTHENIA GRAVIS: A U.S. EXPERIENCE

Author

PASNOOR, MAMATHA, WOLFE, GIL I., NATIONS, SHARON, TRIVEDI, JAYA, BAROHN, RICHARD J., HERBELIN, LAURA, MCVEY, APRIL, DIMACHKIE, MAZEN, KISSEL, JOHN, WALSH, RONAN, AMATO, ANTHONY, MOZAFFAR, TAHSEEN, HUNGS, MARCEL, CHUI, LUIS, GOLDSTEIN, JONATHAN, NOVELLA, STEVEN, BURNS, TED, PHILLIPS, LAWRENCE, CLAUSSEN, GWENDOLYN, YOUNG, ANGELA, BERTORINI, TULIO, and OH, SHIN

Published
2010
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41. Long-term safety and efficacy of eculizumab in generalized myasthenia gravis

Author

Muppidi, Srikanth, Utsugisawa, Kimiaki, Benatar, Michael, Murai, Hiroyuki, Barohn, Richard J., Illa, Isabel, Jacob, Saiju, Vissing, John, Burns, Ted M., Kissel, John T., Nowak, Richard J., Andersen, Henning, Casasnovas, Carlos, de Bleecker, Jan L., Vu, Tuan H., Mantegazza, Renato, O'Brien, Fanny L., Wang, Jing Jing, Fujita, Kenji P., Howard, James F., Mazia, Claudio Gabriel, Wilken, Miguel, Barroso, Fabio, Saba, Juliet, Rugiero, Marcelo, Bettini, Mariela, Chaves, Marcelo, Vidal, Gonzalo, Garcia, Alejandra Dalila, van den Abeele, Guy, de Koning, Kathy, de Mey, Katrien, Mercelis, Rudy, Mahieu, D. lphine, Wagemaekers, Linda, van Damme, Philip, Depreitere, Annelies, Schotte, Caroline, Smetcoren, Charlotte, Stevens, Olivier, van Daele, Sien, Vandenbussche, Nicolas, Vanhee, Annelies, Verjans, Sarah, Vynckier, Jan, D'Hondt, Ann, Tilkin, Petra, Alves de Siqueira Carvalho, Alzira, Dias Brockhausen, Igor, Feder, David, Ambrosio, Daniel, César, Pamela, Melo, Ana Paula, Martins Ribeiro, Renata, Rocha, Rosana, Bezerra Rosa, Bruno, Veiga, Thabata, da Silva, Luiz Augusto, Santos Engel, Murilo, Gonçalves Geraldo, Jordana, Ananias Morita, Maria da Penha, Nogueira Coelho, Erica, Paiva, Gabriel, Pozo, Marina, Prando, Natalia, Martineli Torres, Debora Dada, Butinhao, Cristiani Fernanda, Duran, Gustavo, Gomes da Silva, Tamires Cristina, Otavio Maia Gonçalves, Luiz, Pazetto, Lucas Eduardo, Fialho, Tomás Augusto Suriane, Renata Cubas Volpe, Luciana, Souza Duca, Luciana, Gheller Friedrich, Maurício André, Guerreiro, Alexandre, Mohr, Henrique, Pereira Martins, Maurer, da Cruz Pacheco, Daiane, Ferreira, Luciana, Macagnan, Ana Paula, Pinto, Graziela, de Cassia Santos, Aline, Souza Bulle Oliveira, Acary, Amaral Andrade, Ana Carolina, Annes, Marcelo, Duarte Silva, Liene, Cavalcante Lino, Valeria, Pinto, Wladimir, Assis, Natália, Carrara, Fernanda, Miranda, Carolina, Souza, Iandra, Fernandes, Patricia, Siddiqi, Zaeem, Phan, Cecile, Narayan, Jeffrey, Blackmore, Derrick, Mallon, Ashley, Roderus, Rikki, Watt, Elizabeth, Vohanka, Stanislav, Bednarik, Josef, Chmelikova, Magda, Cierny, Marek, Toncrova, Stanislava, Junkerova, Jana, Kurkova, Barbora, Reguliova, Katarina, Zapletalova, Olga, Pitha, Jiri, Novakova, Iveta, Tyblova, Michaela, Jurajdova, Ivana, Wolfova, Marcela, Harbo, Thomas, Vinge, Lotte, Krogh, Susanne, Mogensen, Anita, Højgaard, Joan, Witting, Nanna, Ostergaard Autzen, Anne, Pedersen, Jane, Eralinna, Juha-Pekka, Laaksonen, Mikko, Oksaranta, Olli, Harrison, Tuula, Eriksson, Jaana, Rozsa, Csilla, Horvath, Melinda, Lovas, Gabor, Matolcsi, Judit, Szabo, Gyorgyi, Jakab, Gedeonne, Szabadosne, Brigitta, Vecsei, Laszlo, Dezsi, Livia, Varga, Edina, Konyane, Monika, Antonini, Giovanni, di Pasquale, Antonella, Garibaldi, Matteo, Morino, Stefania, Troili, Fernanda, Fionda, Laura, Filla, Allessandro, Costabile, Teresa, Marano, Enrico, Saccà, Francesco, Fasanaro, Angiola, Marsili, Angela, Puorro, Giorgia, Antozzi, Carlo, Bonanno, Silvia, Camera, Giorgia, Locatelli, Alberta, Maggi, Lorenzo, Pasanisi, Maria, Campanella, Angela, Evoli, Amelia, Alboini, Paolo Emilio, D'Amato, Valentina, Iorio, Raffaele, Inghilleri, Maurizio, Frasca, Vittorio, Giacomelli, Elena, Gori, Maria, Lopergolo, Diego, Onesti, Emanuela, Gabriele, Maria, Uzawa, Akiyuki, Kanai, Tetsuya, Kawaguchi, Naoki, Mori, Masahiro, Kaneko, Yoko, Kanzaki, Akiko, Kobayashi, Eri, Masaki, Katsuhisa, Matsuse, Dai, Matsushita, Takuya, Uehara, Taira, Shimpo, Misa, Jingu, Maki, Kikutake, Keiko, Nakamura, Yumiko, Sano, Yoshiko, Nagane, Yuriko, Kamegamori, Ikuko, Tsuda, Tomoko, Fujii, Yuko, Futono, Kazumi, Ozawa, Yukiko, Mizugami, Aya, Saito, Yuka, Suzuki, Hidekazu, Morikawa, Miyuki, Samukawa, Makoto, Kamakura, Sachiko, Miyawaki, Eriko, Shiraishi, Hirokazu, Mitazaki, Teiichiro, Motomura, Masakatsu, Mukaino, Akihiro, Yoshimura, Shunsuke, Asada, Shizuka, Yoshida, Seiko, Amamoto, Shoko, Kobashikawa, Tomomi, Koga, Megumi, Maeda, Yasuko, Takada, Kazumi, Takada, Mihoko, Tsurumaru, Masako, Yamashita, Yumi, Suzuki, Yasushi, Akiyama, Tetsuya, Narikawa, Koichi, Tano, Ohito, Tsukita, Kenichi, Kurihara, Rikako, Meguro, Fumie, Fukuda, Yusuke, Sato, Miwako, Okumura, Meinoshin, Funaka, Soichiro, Kawamura, Tomohiro, Makamori, Masayuki, Takahashi, Masanori, Taichi, Namie, Hasuike, Tomoya, Higuchi, Eriko, Kobayashi, Hisako, Osakada, Kaori, Imai, Tomihiro, Tsuda, Emiko, Shimohama, Shun, Hayashi, Takashi, Hisahara, Shin, Kawamata, Jun, Murahara, Takashi, Saitoh, Masaki, Suzuki, Shuichiro, Yamamoto, Daisuke, Ishiyama, Yoko, Ishiyama, Naoko, Noshiro, Mayuko, Takeyama, Rumi, Uwasa, Kaori, Yasuda, Ikuko, van der Kooi, Anneke, de Visser, Marianne, Gibson, Tamar, Kim, Byung-Jo, Lee, Chang Nyoung, Koo, Yong Seo, Seok, Hung Youl, Kang, Hoo Nam, Ra, HyeJin, Kim, Byoung Joon, Cho, Eun Bin, Choi, MiSong, Lee, HyeLim, Min, Ju-Hong, Seok, Jinmyoung, Lee, JiEun, Koh, Da Yoon, Kwon, JuYoung, Park, SangAe, Choi, Eun Hwa, Hong, Yoon-Ho, Ahn, So-Hyun, Koo, Dae Lim, Lim, Jae-Sung, Shin, Chae Won, Hwang, Ji Ye, Kim, Miri, Kim, Seung Min, Jeong, Ha-Neul, Jung, JinWoo, Kim, Yool-hee, Lee, Hyung Seok, Shin, Ha Young, Hwang, Eun Bi, Shin, Miju, Alberti Aguilo, Maria Antonia, Homedes-Pedret, Christian, Julia Palacios, Natalia, Diez Porras, Laura, Velez Santamaria, Valentina, Lazaro, Ana, Diez Tejedor, Exuperio, Gomez Salcedo, Pilar, Fernandez-Fournier, Mireya, Lopez Ruiz, Pedro, Rodriguez de Rivera, Francisco Javier, Sastre, Maria, Gamez, Josep, Sune, Pilar, Salvado, Maria, Gili, Gisela, Mazuela, Gonzalo, Cortes Vicente, Elena, Diaz-Manera, Jordi, Querol Gutierrez, Luis Antonio, Rojas Garcia, Ricardo, Vidal, Nuria, Arribas-Ibar, Elisabet, Piehl, Fredrik, Hietala, Albert, Bjarbo, Lena, Sengun, Ihsan, Meherremova, Arzu, Ozcelik, Pinar, Balkan, Bengu, Tuga, Celal, Ugur, Muzeyyen, Erdem-Ozdamar, Sevim, Bekircan-Kurt, Can Ebru, Acar, Nazire Pinar, Yilmaz, Ezgi, Caliskan, Yagmur, Orsel, Gulsah, Efendi, Husnu, Aydinlik, Seda, Cavus, Hakan, Kutlu, Ayse, Becerikli, Gulsar, Semiz, Cansu, Tun, Ozlem, Terzi, Murat, Dogan, Baki, Onar, Musa Kazim, Sen, Sedat, Kirbas Cavdar, Tugce, Veske, Adife, Norwood, Fiona, Dimitriou, Aikaterini, Gollogly, Jakit, Mahdi-Rogers, Mohamed, Seddigh, Arshira, Sokratous, Giannis, Maier, Gal, Sohail, Faisal, Sadalage, Girija, Torane, Pravin, Brown, Claire, Shah, Amna, Sathasivam, Sivakumar, Arndt, Heike, Davies, Debbie, Watling, Dave, Amato, Anthony, Cochrane, Thomas, Salajegheh, Mohammed, Roe, Kristen, Amato, Katherine, Toska, Shirli, Wolfe, Gil, Silvestri, Nicholas, Patrick, Kara, Zakalik, Karen, Katz, Jonathan, Miller, Robert, Engel, Marguerite, Forshew, Dallas, Bravver, Elena, Brooks, Benjamin, Plevka, Sarah, Burdette, Maryanne, Cunningham, Scott, Sanjak, Mohammad, Kramer, Megan, Nemeth, Joanne, Schommer, Clara, Tierney, Scott, Juel, Vern, Guptill, Jeffrey, Hobson-Webb, Lisa, Massey, Janice, Beck, Kate, Carnes, Donna, Loor, John, Anderson, Amanda, Pascuzzi, Robert, Bodkin, Cynthia, Kincaid, John, Snook, Riley, Guingrich, Sandra, Micheels, Angela, Chaudhry, Vinay, Corse, Andrea, Mosmiller, Betsy, Kelley, Andrea, Ho, Doreen, Srinivasan, Jayashri, Vytopil, Michal, Jara, Jordan, Ventura, Nicholas, Scala, Stephanie, Carter, Cynthia, Donahue, Craig, Herbert, Carol, Weiner, Elaine, Alam, Sharmeen, McKinnon, Jonathan, Haar, Laura, McKinnon, Naya, Alcon, Karan, McKenna, Kaitlyn, Sattar, Nadia, Daniels, Kevin, Jeffery, Dennis, Freimer, Miriam, Hoyle, Joseph Chad, Agriesti, Julie, Chelnick, Sharon, Mezache, Louisa, Pineda, Colleen, Muharrem, Filiz, Karam, Chafic, Khoury, Julie, Marburger, Tessa, Kaur, Harpreet, Dimitrova, Diana, Gilchrist, James, Agrawal, Brajesh, Elsayed, Mona, Kohlrus, Stephanie, Andoin, Angela, Darnell, Taylor, Golden, Laura, Lokaitis, Barbara, Seelback, Jenna, Goyal, Neelam, Sakamuri, Sarada, So, Yuen T., Paulose, Shirley, Pol, Sabrina, Welsh, Lesly, Bhavaraju-Sanka, Ratna, Tobon Gonzales, Alejandro, Dishman, Lorraine, Jones, Floyd, Gonzalez, Anna, Padilla, Patricia, Saklad, Amy, Silva, Marcela, Nations, Sharon, Trivedi, Jaya, Hopkins, Steve, Kazamel, Mohamed, Alsharabati, Mohammad, Lu, Liang, Nozaki, Kenkichi, Mumfrey-Thomas, Sandi, Woodall, Amy, Mozaffar, Tahseen, Cash, Tiyonnoh, Goyal, Namita, Roy, Gulmohor, Mathew, Veena, Maqsood, Fatima, Minton, Brian, Jones, H. James, Rosenfeld, Jeffrey, Garcia, Rebekah, Echevarria, Laura, Garcia, Sonia, Pulley, Michael, Aranke, Shachie, Berger, Alan Ross, Shah, Jaimin, Shabbir, Yasmeen, Smith, Lisa, Varghese, Mary, Gutmann, Laurie, Gutmann, Ludwig, Jerath, Nivedita, Nance, Christopher, Swenson, Andrea, Olalde, Heena, Kressin, Nicole, Sieren, Jeri, Dimachkie, Mazen, Glenn, Melanie, McVey, April, Pasnoor, Mamatha, Statland, Jeffery, Wang, Yunxia, Liu, Tina, Emmons, Kelley, Jenci, Nicole, Locheke, Jerry, Fondaw, Alex, Johns, Kathryn, Rico, Gabrielle, Walsh, Maureen, Herbelin, Laura, Hafer-Macko, Charlene, Kwan, Justin, Zilliox, Lindsay, Callison, Karen, Young, Valerie, DiSanzo, Beth, Naunton, Kerry, Bilsker, Martin, Sharma, Khema, Cooley, Anne, Reyes, Eliana, Michon, Sara-Claude, Sheldon, Danielle, Steele, Julie, Chopra, Manisha, Traub, Rebecca, Katzin, Lara, McClain, Terry, Harvey, Brittany, Hart, Adam, Huynh, Kristin, Beydoun, Said, Chilingaryan, Amaiak, Doan, Victor, Droker, Brian, Gong, Hui, Karimi, Sanaz, Lin, Frank, Pokala, Krishna, Shah, Akshay, Tran, Anh, Akhter, Salma, Malekniazi, Ali, Tandan, Rup, Hehir, Michael, Waheed, Waqar, Lucy, Shannon, Weiss, Michael, Distad, Jane, Strom, Susan, Downing, Sharon, Kim, Bryan, Bertorini, Tulio, Arnold, Thomas, Hendersen, Kendrick, Pillai, Rekha, Liu, Ye, Wheeler, Lauren, Hewlett, Jasmine, Vanderhook, Mollie, Dicapua, Daniel, Keung, Benison, Kumar, Aditya, Patwa, Huned, Robeson, Kimberly, Yang, Irene, Nye, Joan, Vu, Hong, Muppidi, S., Utsugisawa, K., Benatar, M., Murai, H., Barohn, R. J., Illa, I., Jacob, S., Vissing, J., Burns, T. M., Kissel, J. T., Nowak, R. J., Andersen, H., Casasnovas, C., de Bleecker, J. L., Vu, T. H., Mantegazza, R., O'Brien, F. L., Wang, J. J., Fujita, K. P., Howard, J. F., Mazia, C. G., Wilken, M., Barroso, F., Saba, J., Rugiero, M., Bettini, M., Chaves, M., Vidal, G., Garcia, A. D., Van den Abeele, G., de Koning, K., De Mey, K., Mercelis, R., Mahieu, D., Wagemaekers, L., Van Damme, P., Depreitere, A., Schotte, C., Smetcoren, C., Stevens, O., Van Daele, S., Vandenbussche, N., Vanhee, A., Verjans, S., Vynckier, J., D'Hondt, A., Tilkin, P., Alves de Siqueira Carvalho, A., Dias Brockhausen, I., Feder, D., Ambrosio, D., Cesar, P., Melo, A. P., Martins Ribeiro, R., Rocha, R., Bezerra Rosa, B., Veiga, T., da Silva, L. A., Santos Engel, M., Goncalves Geraldo, J., Ananias Morita, M. D. P., Nogueira Coelho, E., Paiva, G., Pozo, M., Prando, N., Martineli Torres, D. D., Butinhao, C. F., Duran, G., Gomes da Silva, T. C., Otavio Maia Goncalves, L., Pazetto, L. E., Fialho, T. A. S., Renata Cubas Volpe, L., Souza Duca, L., Gheller Friedrich, M. A., Guerreiro, A., Mohr, H., Pereira Martins, M., da Cruz Pacheco, D., Ferreira, L., Macagnan, A. P., Pinto, G., de Cassia Santos, A., Souza Bulle Oliveira, A., Amaral Andrade, A. C., Annes, M., Duarte Silva, L., Cavalcante Lino, V., Pinto, W., Assis, N., Carrara, F., Miranda, C., Souza, I., Fernandes, P., Siddiqi, Z., Phan, C., Narayan, J., Blackmore, D., Mallon, A., Roderus, R., Watt, E., Vohanka, S., Bednarik, J., Chmelikova, M., Cierny, M., Toncrova, S., Junkerova, J., Kurkova, B., Reguliova, K., Zapletalova, O., Pitha, J., Novakova, I., Tyblova, M., Jurajdova, I., Wolfova, M., Harbo, T., Vinge, L., Krogh, S., Mogensen, A., Hojgaard, J., Witting, N., Ostergaard Autzen, A., Pedersen, J., Eralinna, J. -P., Laaksonen, M., Oksaranta, O., Harrison, T., Eriksson, J., Rozsa, C., Horvath, M., Lovas, G., Matolcsi, J., Szabo, G., Jakab, G., Szabadosne, B., Vecsei, L., Dezsi, L., Varga, E., Konyane, M., Antonini, G., Di Pasquale, A., Garibaldi, M., Morino, S., Troili, F., Fionda, L., Filla, A., Costabile, T., Marano, E., Sacca, F., Fasanaro, A., Marsili, A., Puorro, G., Antozzi, C., Bonanno, S., Camera, G., Locatelli, A., Maggi, L., Pasanisi, M., Campanella, A., Evoli, A., Alboini, P. E., D'Amato, V., Iorio, R., Inghilleri, M., Frasca, V., Giacomelli, E., Gori, M., Lopergolo, D., Onesti, E., Gabriele, M., Uzawa, A., Kanai, T., Kawaguchi, N., Mori, M., Kaneko, Y., Kanzaki, A., Kobayashi, E., Masaki, K., Matsuse, D., Matsushita, T., Uehara, T., Shimpo, M., Jingu, M., Kikutake, K., Nakamura, Y., Sano, Y., Nagane, Y., Kamegamori, I., Tsuda, T., Fujii, Y., Futono, K., Ozawa, Y., Mizugami, A., Saito, Y., Suzuki, H., Morikawa, M., Samukawa, M., Kamakura, S., Miyawaki, E., Shiraishi, H., Mitazaki, T., Motomura, M., Mukaino, A., Yoshimura, S., Asada, S., Yoshida, S., Amamoto, S., Kobashikawa, T., Koga, M., Maeda, Y., Takada, K., Takada, M., Tsurumaru, M., Yamashita, Y., Suzuki, Y., Akiyama, T., Narikawa, K., Tano, O., Tsukita, K., Kurihara, R., Meguro, F., Fukuda, Y., Sato, M., Okumura, M., Funaka, S., Kawamura, T., Makamori, M., Takahashi, M., Taichi, N., Hasuike, T., Higuchi, E., Kobayashi, H., Osakada, K., Imai, T., Tsuda, E., Shimohama, S., Hayashi, T., Hisahara, S., Kawamata, J., Murahara, T., Saitoh, M., Suzuki, S., Yamamoto, D., Ishiyama, Y., Ishiyama, N., Noshiro, M., Takeyama, R., Uwasa, K., Yasuda, I., van der Kooi, A., de Visser, M., Gibson, T., Kim, B. -J., Lee, C. N., Koo, Y. S., Seok, H. Y., Kang, H. N., Ra, H., Kim, B. J., Cho, E. B., Choi, M., Lee, H., Min, J. -H., Seok, J., Lee, J., Koh, D. Y., Kwon, J., Park, S., Choi, E. H., Hong, Y. -H., Ahn, S. -H., Koo, D. L., Lim, J. -S., Shin, C. W., Hwang, J. Y., Kim, M., Kim, S. M., Jeong, H. -N., Jung, J., Kim, Y. -H., Lee, H. S., Shin, H. Y., Hwang, E. B., Shin, M., Alberti Aguilo, M. A., Homedes-Pedret, C., Julia Palacios, N., Diez Porras, L., Velez Santamaria, V., Lazaro, A., Diez Tejedor, E., Gomez Salcedo, P., Fernandez-Fournier, M., Lopez Ruiz, P., Rodriguez de Rivera, F. J., Sastre, M., Gamez, J., Sune, P., Salvado, M., Gili, G., Mazuela, G., Cortes Vicente, E., Diaz-Manera, J., Querol Gutierrez, L. A., Rojas Garcia, R., Vidal, N., Arribas-Ibar, E., Piehl, F., Hietala, A., Bjarbo, L., Sengun, I., Meherremova, A., Ozcelik, P., Balkan, B., Tuga, C., Ugur, M., Erdem-Ozdamar, S., Bekircan-Kurt, C. E., Acar, N. P., Yilmaz, E., Caliskan, Y., Orsel, G., Efendi, H., Aydinlik, S., Cavus, H., Kutlu, A., Becerikli, G., Semiz, C., Tun, O., Terzi, M., Dogan, B., Onar, M. K., Sen, S., Kirbas Cavdar, T., Veske, A., Norwood, F., Dimitriou, A., Gollogly, J., Mahdi-Rogers, M., Seddigh, A., Sokratous, G., Maier, G., Sohail, F., Sadalage, G., Torane, P., Brown, C., Shah, A., Sathasivam, S., Arndt, H., Davies, D., Watling, D., Amato, A., Cochrane, T., Salajegheh, M., Roe, K., Amato, K., Toska, S., Wolfe, G., Silvestri, N., Patrick, K., Zakalik, K., Katz, J., Miller, R., Engel, M., Forshew, D., Bravver, E., Brooks, B., Plevka, S., Burdette, M., Cunningham, S., Sanjak, M., Kramer, M., Nemeth, J., Schommer, C., Tierney, S., Juel, V., Guptill, J., Hobson-Webb, L., Massey, J., Beck, K., Carnes, D., Loor, J., Anderson, A., Pascuzzi, R., Bodkin, C., Kincaid, J., Snook, R., Guingrich, S., Micheels, A., Chaudhry, V., Corse, A., Mosmiller, B., Kelley, A., Ho, D., Srinivasan, J., Vytopil, M., Jara, J., Ventura, N., Scala, S., Carter, C., Donahue, C., Herbert, C., Weiner, E., Alam, S., Mckinnon, J., Haar, L., Mckinnon, N., Alcon, K., Mckenna, K., Sattar, N., Daniels, K., Jeffery, D., Freimer, M., Hoyle, J. C., Agriesti, J., Chelnick, S., Mezache, L., Pineda, C., Muharrem, F., Karam, C., Khoury, J., Marburger, T., Kaur, H., Dimitrova, D., Gilchrist, J., Agrawal, B., Elsayed, M., Kohlrus, S., Andoin, A., Darnell, T., Golden, L., Lokaitis, B., Seelback, J., Goyal, N., Sakamuri, S., So, Y. T., Paulose, S., Pol, S., Welsh, L., Bhavaraju-Sanka, R., Tobon Gonzales, A., Dishman, L., Jones, F., Gonzalez, A., Padilla, P., Saklad, A., Silva, M., Nations, S., Trivedi, J., Hopkins, S., Kazamel, M., Alsharabati, M., Lu, L., Nozaki, K., Mumfrey-Thomas, S., Woodall, A., Mozaffar, T., Cash, T., Roy, G., Mathew, V., Maqsood, F., Minton, B., Jones, H. J., Rosenfeld, J., Garcia, R., Echevarria, L., Garcia, S., Pulley, M., Aranke, S., Berger, A. 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Subjects
0301 basic medicine, Male, Pediatrics, Exacerbation, Physiology, Heart Diseases/chemically induced, Myasthenia Gravis/drug therapy, 030105 genetics & heredity, THERAPY, DOUBLE-BLIND, 0302 clinical medicine, Quality of life, Monoclonal, Activities of Daily Living, Medicine and Health Sciences, Functional ability, Longitudinal Studies, Humanized, Angioedema/chemically induced, MG-ADL, QMG, Eculizumab, Middle Aged, myasthenia gravi, 3. Good health, Treatment Outcome, Antibodies, Monoclonal, Humanized/therapeutic use, Meningococcal Infections/epidemiology, Disease Progression, Female, eculizumab, Life Sciences & Biomedicine, COMPLEMENT INHIBITOR ECULIZUMAB, medicine.drug, Adult, medicine.medical_specialty, MG-QOL15, Heart Diseases, Clinical Neurology, Meningococcal Vaccines, Antibodies, Monoclonal, Humanized, Placebo, Antibodies, ACETYLCHOLINE-RECEPTOR, Complement Inactivating Agents/therapeutic use, 03 medical and health sciences, Cellular and Molecular Neuroscience, Refractory, Physiology (medical), Injection Site Reaction/epidemiology, Myasthenia Gravis, medicine, Aspergillosis, Aspergillosis/epidemiology, Humans, Muscle Strength, Angioedema, myasthenia gravis, Science & Technology, business.industry, MGC, Neurosciences, Meningococcal Vaccines/therapeutic use, medicine.disease, Interim analysis, Complement Inactivating Agents, Injection Site Reaction, Meningococcal Infections, Quality of Life, Myasthenia gravis, ANTIBODY, Neurosciences & Neurology, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

INTRODUCTION: Eculizumab is effective and well tolerated in patients with antiacetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG; REGAIN; NCT01997229). We report an interim analysis of an open-label extension of REGAIN, evaluating eculizumab's long-term safety and efficacy. METHODS: Eculizumab (1,200 mg every 2 weeks for 22.7 months [median]) was administered to 117 patients. RESULTS: The safety profile of eculizumab was consistent with REGAIN; no cases of meningococcal infection were reported during the interim analysis period. Myasthenia gravis exacerbation rate was reduced by 75% from the year before REGAIN (P

Published
2019
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44. Rasagiline for Amyotrophic Lateral Sclerosis: a Randomized Controlled Trial

Author

Statland, Jeffrey M, Moore, Dan, Wang, Yunxia, Walsh, Maureen, Mozaffar, Tahseen, Elman, Lauren, Nations, Sharon, Mitsumoto, Hiroshi, Fernandes, J Americo, Saperstein, David, Hayat, Ghazala, Herbelin, Laura, Karam, Chafic, Katz, Jonathan, Wilkins, Heather M., Agbas, Abdulbaki, Swerdlow, Russell H., Santella, Regina M., Dimachkie, Mazen M., and Barohn, Richard J.

Subjects
Adult, Aged, 80 and over, Male, Amyotrophic Lateral Sclerosis, Middle Aged, Severity of Illness Index, Article, United States, DNA-Binding Proteins, Young Adult, Neuroprotective Agents, Treatment Outcome, Double-Blind Method, Indans, Outcome Assessment, Health Care, Quality of Life, Humans, Female, Aged, Retrospective Studies
Abstract

INTRODUCTION: Rasagiline is an MAO-B inhibitor with possible neuroprotective effects in patients with amyotrophic lateral sclerosis (ALS). METHODS: We performed a randomized, double-blind, placebo-controlled trial of 80 ALS participants with enrichment of the placebo group with historical controls (n=177) at 10 centers in the United States. Participants were randomized in a 3:1 ratio to 2 mg rasagiline daily or placebo. The primary outcome was the average slope of decline of the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary measures included slow vital capacity, survival, mitochondrial and molecular biomarkers, and adverse event reporting. RESULTS: There was no difference in the average 12 months ALSFRS-R slope between rasagiline and the mixed placebo and historical control cohorts. Rasagiline did not show signs of drug-target engagement in urine and blood biomarkers. Rasagiline was well tolerated with no serious adverse events. DISCUSSION: Rasagiline did not alter disease progression compared to controls over 12 months of treatment. Clinicaltrials.gov identifier: NCT01786603.

Published
2018

45. Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study

Author

Murai, Hiroyuki, primary, Uzawa, Akiyuki, additional, Suzuki, Yasushi, additional, Imai, Tomihiro, additional, Shiraishi, Hirokazu, additional, Suzuki, Hidekazu, additional, Okumura, Meinoshin, additional, O’Brien, Fanny, additional, Wang, Jing-Jing, additional, Fujita, Kenji P., additional, Utsugisawa, Kimiaki, additional, Mazia, Claudio Gabriel, additional, Wilken, Miguel, additional, Barroso, Fabio, additional, Saba, Juliet, additional, Rugiero, Marcelo, additional, Bettini, Mariela, additional, Chaves, Marcelo, additional, Vidal, Gonzalo, additional, Garcia, Alejandra Dalila, additional, De Bleecker, Jan, additional, Van den Abeele, Guy, additional, de Koning, Kathy, additional, De Mey, Katrien, additional, Mercelis, Rudy, additional, Mahieu, Délphine, additional, Wagemaekers, Linda, additional, Van Damme, Philip, additional, Depreitere, Annelies, additional, Schotte, Caroline, additional, Smetcoren, Charlotte, additional, Stevens, Olivier, additional, Van Daele, Sien, additional, Vandenbussche, Nicolas, additional, Vanhee, Annelies, additional, Verjans, Sarah, additional, Vynckier, Jan, additional, D'Hondt, Ann, additional, Tilkin, Petra, additional, Alves de Siqueira Carvalho, Alzira, additional, Dias Brockhausen, Igor, additional, Feder, David, additional, Ambrosio, Daniel, additional, César, Pamela, additional, Melo, Ana Paula, additional, Martins Ribeiro, Renata, additional, Rocha, Rosana, additional, Bezerra Rosa, Bruno, additional, Veiga, Thabata, additional, da Silva, Luiz Augusto, additional, Santos Engel, Murilo, additional, Gonçalves Geraldo, Jordana, additional, Ananias Morita, Maria da Penha, additional, Nogueira Coelho, Erica, additional, Paiva, Gabriel, additional, Pozo, Marina, additional, Prando, Natalia, additional, Martineli Torres, Debora Dada, additional, Butinhao, Cristiani Fernanda, additional, Duran, Gustavo, additional, Gomes da Silva, Tamires Cristina, additional, Otavio Maia Gonçalves, Luiz, additional, Pazetto, Lucas Eduardo, additional, Fialho, Tomás Augusto Suriane, additional, Renata Cubas Volpe, Luciana, additional, Souza Duca, Luciana, additional, Souza Bulle Oliveira, Acary, additional, Amaral Andrade, Ana Carolina, additional, Annes, Marcelo, additional, Duarte Silva, Liene, additional, Cavalcante Lino, Valeria, additional, Pinto, Wladimir, additional, Assis, Natália, additional, Carrara, Fernanda, additional, Miranda, Carolina, additional, Souza, Iandra, additional, Fernandes, Patricia, additional, Siddiqi, Zaeem, additional, Phan, Cecile, additional, Narayan, Jeffrey, additional, Blackmore, Derrick, additional, Mallon, Ashley, additional, Roderus, Rikki, additional, Watt, Elizabeth, additional, Junkerova, Jana, additional, Kurkova, Barbora, additional, Reguliova, Katarina, additional, Zapletalova, Olga, additional, Pitha, Jiri, additional, Novakova, Iveta, additional, Tyblova, Michaela, additional, Jurajdova, Ivana, additional, Wolfova, Marcela, additional, Andersen, Henning, additional, Harbo, Thomas, additional, Vinge, Lotte, additional, Krogh, Susanne, additional, Mogensen, Anita, additional, Vissing, John, additional, Højgaard, Joan, additional, Witting, Nanna, additional, Mette Ostergaard Autzen, Anne, additional, Pedersen, Jane, additional, Eralinna, Juha-Pekka, additional, Laaksonen, Mikko, additional, Oksaranta, Olli, additional, Harrison, Tuula, additional, Eriksson, Jaana, additional, Rozsa, Csilla, additional, Horvath, Melinda, additional, Lovas, Gabor, additional, Matolcsi, Judit, additional, Szabo, Gyorgyi, additional, Jakab, Gedeonne, additional, Szabadosne, Brigitta, additional, Antonini, Giovanni, additional, Di Pasquale, Antonella, additional, Garibaldi, Matteo, additional, Morino, Stefania, additional, Troili, Fernanda, additional, Fionda, Laura, additional, Filla, Allessandro, additional, Costabile, Teresa, additional, Marano, Enrico, additional, Saccà, Francesco, additional, Fasanaro, Angiola, additional, Marsili, Angela, additional, Puorro, Giorgia, additional, Mantegazza, Renato, additional, Antozzi, Carlo, additional, Bonanno, Silvia, additional, Camera, Giorgia, additional, Locatelli, Alberta, additional, Maggi, Lorenzo, additional, Pasanisi, Maria, additional, Campanella, Angela, additional, Evoli, Amelia, additional, Alboini, Paolo Emilio, additional, D'Amato, Valentina, additional, Iorio, Raffaele, additional, Kanai, Tetsuya, additional, Kawaguchi, Naoki, additional, Mori, Masahiro, additional, Kaneko, Yoko, additional, Kanzaki, Akiko, additional, Kobayashi, Eri, additional, Masaki, Katsuhisa, additional, Matsuse, Dai, additional, Matsushita, Takuya, additional, Uehara, Taira, additional, Shimpo, Misa, additional, Jingu, Maki, additional, Kikutake, Keiko, additional, Nakamura, Yumiko, additional, Sano, Yoshiko, additional, Nagane, Yuriko, additional, Kamegamori, Ikuko, additional, Tsuda, Tomoko, additional, Fujii, Yuko, additional, Futono, Kazumi, additional, Ozawa, Yukiko, additional, Mizugami, Aya, additional, Saito, Yuka, additional, Morikawa, Miyuki, additional, Samukawa, Makoto, additional, Kamakura, Sachiko, additional, Miyawaki, Eriko, additional, Mitazaki, Teiichiro, additional, Motomura, Masakatsu, additional, Mukaino, Akihiro, additional, Yoshimura, Shunsuke, additional, Asada, Shizuka, additional, Yoshida, Seiko, additional, Amamoto, Shoko, additional, Kobashikawa, Tomomi, additional, Koga, Megumi, additional, Maeda, Yasuko, additional, Takada, Kazumi, additional, Takada, Mihoko, additional, Tsurumaru, Masako, additional, Yamashita, Yumi, additional, Akiyama, Tetsuya, additional, Narikawa, Koichi, additional, Tano, Ohito, additional, Tsukita, Kenichi, additional, Kurihara, Rikako, additional, Meguro, Fumie, additional, Fukuda, Yusuke, additional, Sato, Miwako, additional, Funaka, Soichiro, additional, Kawamura, Tomohiro, additional, Makamori, Masayuki, additional, Takahashi, Masanori, additional, Taichi, Namie, additional, Hasuike, Tomoya, additional, Higuchi, Eriko, additional, Kobayashi, Hisako, additional, Osakada, Kaori, additional, Tsuda, Emiko, additional, Shimohama, Shun, additional, Hayashi, Takashi, additional, Hisahara, Shin, additional, Kawamata, Jun, additional, Murahara, Takashi, additional, Saitoh, Masaki, additional, Suzuki, Shuichiro, additional, Yamamoto, Daisuke, additional, Ishiyama, Yoko, additional, Ishiyama, Naoko, additional, Noshiro, Mayuko, additional, Takeyama, Rumi, additional, Uwasa, Kaori, additional, Yasuda, Ikuko, additional, van der Kooi, Anneke, additional, de Visser, Marianne, additional, Gibson, Tamar, additional, Casasnovas, Carlos, additional, Alberti Aguilo, Maria Antonia, additional, Homedes-Pedret, Christian, additional, Julia Palacios, Natalia, additional, Diez Porras, Laura, additional, Velez Santamaria, Valentina, additional, Lazaro, Ana, additional, Diez Tejedor, Exuperio, additional, Gomez Salcedo, Pilar, additional, Fernandez-Fournier, Mireya, additional, Lopez Ruiz, Pedro, additional, Rodriguez de Rivera, Francisco Javier, additional, Sastre, Maria, additional, Gamez, Josep, additional, Sune, Pilar, additional, Salvado, Maria, additional, Gili, Gisela, additional, Mazuela, Gonzalo, additional, Illa, Isabel, additional, Cortes Vicente, Elena, additional, Diaz-Manera, Jordi, additional, Querol Gutierrez, Luis Antonio, additional, Rojas Garcia, Ricardo, additional, Vidal, Nuria, additional, Arribas-Ibar, Elisabet, additional, Piehl, Fredrik, additional, Hietala, Albert, additional, Bjarbo, Lena, additional, Sengun, Ihsan, additional, Meherremova, Arzu, additional, Ozcelik, Pinar, additional, Balkan, Bengu, additional, Tuga, Celal, additional, Ugur, Muzeyyen, additional, Erdem-Ozdamar, Sevim, additional, Bekircan-Kurt, Can Ebru, additional, Acar, Nazire Pinar, additional, Yilmaz, Ezgi, additional, Caliskan, Yagmur, additional, Orsel, Gulsah, additional, Efendi, Husnu, additional, Aydinlik, Seda, additional, Cavus, Hakan, additional, Kutlu, Ayse, additional, Becerikli, Gulsah, additional, Semiz, Cansu, additional, Tun, Ozlem, additional, Terzi, Murat, additional, Dogan, Baki, additional, Onar, Musa Kazim, additional, Sen, Sedat, additional, Kirbas Cavdar, Tugce, additional, Veske, Adife, additional, Norwood, Fiona, additional, Dimitriou, Aikaterini, additional, Gollogly, Jakit, additional, Mahdi-Rogers, Mohamed, additional, Seddigh, Arshira, additional, Sokratous, Giannis, additional, Maier, Gal, additional, Sohail, Faisal, additional, Jacob, Saiju, additional, Sadalage, Girija, additional, Torane, Pravin, additional, Brown, Claire, additional, Shah, Amna, additional, Sathasivam, Sivakumar, additional, Arndt, Heike, additional, Davies, Debbie, additional, Watling, Dave, additional, Amato, Anthony, additional, Cochrane, Thomas, additional, Salajegheh, Mohammed, additional, Roe, Kristen, additional, Amato, Katherine, additional, Toska, Shirli, additional, Wolfe, Gil, additional, Silvestri, Nicholas, additional, Patrick, Kara, additional, Zakalik, Karen, additional, Katz, Jonathan, additional, Miller, Robert, additional, Engel, Marguerite, additional, Forshew, Dallas, additional, Bravver, Elena, additional, Brooks, Benjamin, additional, Plevka, Sarah, additional, Burdette, Maryanne, additional, Cunningham, Scott, additional, Sanjak, Mohammad, additional, Kramer, Megan, additional, Nemeth, Joanne, additional, Schommer, Clara, additional, Tierney, Scott, additional, Juel, Vern, additional, Guptill, Jeffrey, additional, Hobson-Webb, Lisa, additional, Massey, Janice, additional, Beck, Kate, additional, Carnes, Donna, additional, Loor, John, additional, Anderson, Amanda, additional, Pascuzzi, Robert, additional, Bodkin, Cynthia, additional, Kincaid, John, additional, Snook, Riley, additional, Guingrich, Sandra, additional, Micheels, Angela, additional, Chaudhry, Vinay, additional, Corse, Andrea, additional, Mosmiller, Betsy, additional, Kelley, Andrea, additional, Ho, Doreen, additional, Srinivasan, Jayashri, additional, Vytopil, Michal, additional, Jara, Jordan, additional, Ventura, Nicholas, additional, Scala, Stephanie, additional, Carter, Cynthia, additional, Donahue, Craig, additional, Herbert, Carol, additional, Weiner, Elaine, additional, Alam, Sharmeen, additional, McKinnon, Jonathan, additional, Haar, Laura, additional, McKinnon, Naya, additional, Alcon, Karan, additional, McKenna, Kaitlyn, additional, Sattar, Nadia, additional, Daniels, Kevin, additional, Jeffery, Dennis, additional, Freimer, Miriam, additional, Hoyle, Joseph Chad, additional, Kissel, John, additional, Agriesti, Julie, additional, Chelnick, Sharon, additional, Mezache, Louisa, additional, Pineda, Colleen, additional, Muharrem, Filiz, additional, Karam, Chafic, additional, Khoury, Julie, additional, Marburger, Tessa, additional, Kaur, Harpreet, additional, Dimitrova, Diana, additional, Gilchrist, James, additional, Agrawal, Brajesh, additional, Elsayed, Mona, additional, Kohlrus, Stephanie, additional, Andoin, Angela, additional, Darnell, Taylor, additional, Golden, Laura, additional, Lokaitis, Barbara, additional, Seelback, Jenna, additional, Muppidi, Srikanth, additional, Goyal, Neelam, additional, Sakamuri, Sarada, additional, So, Yuen T., additional, Paulose, Shirley, additional, Pol, Sabrina, additional, Welsh, Lesly, additional, Bhavaraju-Sanka, Ratna, additional, Tobon Gonzales, Alejandro, additional, Dishman, Lorraine, additional, Jones, Floyd, additional, Gonzalez, Anna, additional, Padilla, Patricia, additional, Saklad, Amy, additional, Silva, Marcela, additional, Kazamel, Mohamed, additional, Alsharabati, Mohammad, additional, Lu, Liang, additional, Nozaki, Kenkichi, additional, Mumfrey-Thomas, Sandi, additional, Woodall, Amy, additional, Mozaffar, Tahseen, additional, Cash, Tiyonnoh, additional, Goyal, Namita, additional, Roy, Gulmohor, additional, Mathew, Veena, additional, Maqsood, Fatima, additional, Minton, Brian, additional, Jones, H. James, additional, Rosenfeld, Jeffrey, additional, Garcia, Rebekah, additional, Echevarria, Laura, additional, Garcia, Sonia, additional, Pulley, Michael, additional, Aranke, Shachie, additional, Berger, Alan Ross, additional, Shah, Jaimin, additional, Shabbir, Yasmeen, additional, Smith, Lisa, additional, Varghese, Mary, additional, Gutmann, Laurie, additional, Gutmann, Ludwig, additional, Jerath, Nivedita, additional, Nance, Christopher, additional, Swenson, Andrea, additional, Olalde, Heena, additional, Kressin, Nicole, additional, Sieren, Jeri, additional, Barohn, Richard, additional, Dimachkie, Mazen, additional, Glenn, Melanie, additional, McVey, April, additional, Pasnoor, Mamatha, additional, Statland, Jeffery, additional, Wang, Yunxia, additional, Liu, Tina, additional, Emmons, Kelley, additional, Jenci, Nicole, additional, Locheke, Jerry, additional, Fondaw, Alex, additional, Johns, Kathryn, additional, Rico, Gabrielle, additional, Walsh, Maureen, additional, Herbelin, Laura, additional, Hafer-Macko, Charlene, additional, Kwan, Justin, additional, Zilliox, Lindsay, additional, Callison, Karen, additional, Young, Valerie, additional, DiSanzo, Beth, additional, Naunton, Kerry, additional, Benatar, Michael, additional, Bilsker, Martin, additional, Sharma, Khema, additional, Cooley, Anne, additional, Reyes, Eliana, additional, Michon, Sara-Claude, additional, Sheldon, Danielle, additional, Steele, Julie, additional, Howard Jr, James, additional, Chopra, Manisha, additional, Traub, Rebecca, additional, Vu, Tuan, additional, Katzin, Lara, additional, McClain, Terry, additional, Harvey, Brittany, additional, Hart, Adam, additional, Huynh, Kristin, additional, Beydoun, Said, additional, Chilingaryan, Amaiak, additional, Doan, Victor, additional, Droker, Brian, additional, Gong, Hui, additional, Karimi, Sanaz, additional, Lin, Frank, additional, Pokala, Krishna, additional, Shah, Akshay, additional, Tran, Anh, additional, Akhter, Salma, additional, Malekniazi, Ali, additional, Tandan, Rup, additional, Hehir, Michael, additional, Waheed, Waqar, additional, Lucy, Shannon, additional, Weiss, Michael, additional, Distad, Jane, additional, Strom, Susan, additional, Downing, Sharon, additional, Kim, Bryan, additional, Nowak, Richard, additional, Dicapua, Daniel, additional, Keung, Benison, additional, Kumar, Aditya, additional, Patwa, Huned, additional, Robeson, Kimberly, additional, Yang, Irene, additional, Nye, Joan, additional, and Vu, Hong, additional

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2019
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46. Investigation of the psychometric properties of the inclusion body myositis functional rating scale with rasch analysis

Author

Ramdharry, Gita, primary, Morrow, Jasper, additional, Hudgens, Stacie, additional, Skorupinska, Iwona, additional, Gwathmey, Kelly, additional, Currence, Melissa, additional, Herbelin, Laura, additional, Jawdat, Omar, additional, Pasnoor, Mamatha, additional, Mcvey, April, additional, Barohn, Richard J., additional, Burns, Ted M., additional, Dimachkie, Mazen M., additional, Amato, Anthony A., additional, Hanna, Michael G., additional, and Machado, Pedro M., additional

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2019
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47. 2269-PUB: Early Attrition from a Randomized Lifestyle Modification Protocol

Author

REVERE, CATHY, primary, SMITH, A. GORDON, additional, KLUDING, PATRICIA, additional, MARCUS, ROBIN L., additional, DIMACHKIE, MAZEN, additional, VIVANCO, FELIX, additional, FOSTER-PALMER, STORMY C., additional, HAUER, PETER E., additional, APERGHIS, ADRIENNE B., additional, PASNOOR, MAMATHA, additional, STONEBRAKER, ANGELA, additional, HAWKS, ALEXIS N., additional, HERBELIN, LAURA, additional, and SINGLETON, J. ROBINSON, additional

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2019
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48. Subcutaneous Immunoglobulin in Myasthenia Gravis: Results of a North American Open Label Study (N4.002)

Author

Dimachkie, Mazen, primary, Bril, Vera, additional, Levine, Todd, additional, Trivedi, Jaya, additional, Silvestri, Nicholas, additional, Phadnis, Milind, additional, Saperstein, David, additional, Nations, Sharon, additional, Katzberg, Hans, additional, Wolfe, Gil, additional, Herbelin, Laura, additional, Higgs, Kiley, additional, Heim, Andrew, additional, McVey, April, additional, Rico, Gabrielle, additional, Statland, Jeffrey, additional, Barohn, Richard, additional, and Pasnoor, Mamatha, additional

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2019
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49. Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

Author

Wolfe, Gil I, primary, Kaminski, Henry J, additional, Aban, Inmaculada B, additional, Minisman, Greg, additional, Kuo, Hui-Chien, additional, Marx, Alexander, additional, Ströbel, Philipp, additional, Mazia, Claudio, additional, Oger, Joel, additional, Cea, J Gabriel, additional, Heckmann, Jeannine M, additional, Evoli, Amelia, additional, Nix, Wilfred, additional, Ciafaloni, Emma, additional, Antonini, Giovanni, additional, Witoonpanich, Rawiphan, additional, King, John O, additional, Beydoun, Said R, additional, Chalk, Colin H, additional, Barboi, Alexandru C, additional, Amato, Anthony A, additional, Shaibani, Aziz I, additional, Katirji, Bashar, additional, Lecky, Bryan R F, additional, Buckley, Camilla, additional, Vincent, Angela, additional, Dias-Tosta, Elza, additional, Yoshikawa, Hiroaki, additional, Waddington-Cruz, Márcia, additional, Pulley, Michael T, additional, Rivner, Michael H, additional, Kostera-Pruszczyk, Anna, additional, Pascuzzi, Robert M, additional, Jackson, Carlayne E, additional, Verschuuren, Jan J G M, additional, Massey, Janice M, additional, Kissel, John T, additional, Werneck, Lineu C, additional, Benatar, Michael, additional, Barohn, Richard J, additional, Tandan, Rup, additional, Mozaffar, Tahseen, additional, Silvestri, Nicholas J, additional, Conwit, Robin, additional, Sonett, Joshua R, additional, Jaretzki, Alfred, additional, Newsom-Davis, John, additional, Cutter, Gary R, additional, Cutter, Gary, additional, Aban, Inmaculada, additional, Feese, Michelle, additional, Wolfe, Gil, additional, Kaminski, Henry, additional, Sonett, Joshua, additional, Saluto, Valeria, additional, Rosenberg, Moises, additional, Alvarez, Valeria, additional, Rey, Lisa, additional, King, John, additional, Butzkueven, Helmut, additional, Goldblatt, John, additional, Carey, John, additional, Pollard, John, additional, Reddel, Stephen, additional, Handel, Nicholas, additional, McCaughan, Brian, additional, Pallot, Linda, additional, Novis, Ricardo, additional, Boasquevisque, Carlos, additional, Morato-Fernandez, Rubens, additional, Ximenes, Manoel, additional, Werneck, Lineu, additional, Scola, Rosana, additional, Soltoski, Paulo, additional, Chalk, Colin, additional, Moore, Fraser, additional, Mulder, David, additional, Wadup, Lisa, additional, Mezei, Michele, additional, Evans, Kenneth, additional, Jiwa, Theresa, additional, Schaffar, Anne, additional, White, Chris, additional, Toth, Cory, additional, Gelfand, Gary, additional, Wood, Susan, additional, Pringle, Elizabeth, additional, Zwicker, Jocelyn, additional, Maziak, Donna, additional, Shamji, Farid, additional, Sundaresan, Sudhir, additional, Seely, Andrew, additional, Cea, Gabriel, additional, Verduga, Renato, additional, Aguayo, Alberto, additional, Jander, Sebastian, additional, Zickler, Philipp, additional, Klein, Michael, additional, Weis, Cleo-Aron, additional, Melms, Arthur, additional, Bischof, Felix, additional, Aebert, Hermann, additional, Ziemer, Gerhard, additional, Thümler, Björn, additional, Wilhem-Schwenkmezger, Thomas, additional, Mayer, Eckhard, additional, Schalke, Berthold, additional, Pöschel, Peter, additional, Hieber, Gisela, additional, Wiebe, Karsten, additional, Clemenzi, Alessandro, additional, Ceschin, Vanessa, additional, Rendina, Erino, additional, Venuta, Federico, additional, Morino, Stefania, additional, Bucci, Elisabetta, additional, Durelli, Luca, additional, Tavella, Alessia, additional, Clerico, Marinella, additional, Contessa, Giulia, additional, Borasio, Piero, additional, Servidei, Serenella, additional, Granone, Pierluigi, additional, Mantegazza, Renato, additional, Berta, Emilia, additional, Novellino, Lorenzo, additional, Spinelli, Luisa, additional, Motomura, Masakatsu, additional, Matsuo, Hidenori, additional, Nagayasu, Takeshi, additional, Takamori, Masaharu, additional, Oda, Makoto, additional, Matsumoto, Isao, additional, Furukawa, Yutaka, additional, Noto, Daisuke, additional, Motozaki, Yuko, additional, Iwasa, Kazuo, additional, Yanase, Daisuke, additional, Garcia Ramos, Guillermo, additional, Cacho, Bernardo, additional, de la Garza, Lorenzo, additional, Kostera-Pruszczyk, Anne, additional, Lipowska, Marta, additional, Kwiecinski, Hubert, additional, Potulska-Chromik, Anna, additional, Orlowski, Tadeusz, additional, Silva, Ana, additional, Feijo, Marta, additional, Freitas, António, additional, Heckmann, Jeannine, additional, Frost, Andrew, additional, Pan, Edward, additional, Tucker, Lawrence, additional, Rossouw, Johan, additional, Drummond, Fiona, additional, Illa, Isabel, additional, Diaz, Jorge, additional, Leon, Carlos, additional, Yeh, Jiann-Horng, additional, Chiu, Hou-Chang, additional, Hsieh, Yei-San, additional, Tunlayadechanont, Supoch, additional, Attanavanich, Sukasom, additional, Verschuuren, Jan, additional, Straathof, Chiara, additional, Titulaer, Maarten, additional, Versteegh, Michel, additional, Pels, Arda, additional, Krum, Yvonne, additional, Leite, M. Isabel, additional, Hilton-Jones, David, additional, Ratnatunga, Chandi, additional, Farrugia, Maria, additional, Petty, Richard, additional, Overell, James, additional, Kirk, Alan, additional, Gibson, Andrew, additional, McDermott, Chris, additional, Hopkinson, David, additional, Lecky, Bryan, additional, Watling, David, additional, Marshall, Dot, additional, Saminaden, Sam, additional, Davies, Deborah, additional, Dougan, Charlotte, additional, Sathasivam, Siva, additional, Page, Richard, additional, Sussman, Jon, additional, Ealing, John, additional, Krysiak, Peter, additional, Amato, Anthony, additional, Salajegheh, Mohammad, additional, Jaklitsch, Michael, additional, Roe, Kristen, additional, Ashizawa, Tetsuo, additional, Smith, Robert Glenn, additional, Zwischenberg, Joseph, additional, Stanton, Penny, additional, Barboi, Alexandru, additional, Jaradeh, Safwan, additional, Tisol, William, additional, Gasparri, Mario, additional, Haasler, George, additional, Yellick, Mary, additional, Dennis, Cedric, additional, Barohn, Richard, additional, Pasnoor, Mamatha, additional, Dimachkie, Mazen, additional, McVey, April, additional, Gronseth, Gary, additional, Dick, Arthur, additional, Kramer, Jeffrey, additional, Currence, Melissa, additional, Herbelin, Laura, additional, Belsh, Jerry, additional, Li, George, additional, Langenfeld, John, additional, Mertz, Mary Ann, additional, Harrison, Taylor, additional, Force, Seth, additional, Usher, Sharon, additional, Beydoun, Said, additional, Lin, Frank, additional, DeMeester, Steve, additional, Akhter, Salem, additional, Malekniazi, Ali, additional, Avenido, Gina, additional, Crum, Brian, additional, Milone, Margherita, additional, Cassivi, Stephen, additional, Fisher, Janet, additional, Heatwole, Chad, additional, Watson, Thomas, additional, Hilbert, James, additional, Smirnow, Alexis, additional, Distad, B. Jane, additional, Weiss, Michael, additional, Wood, Douglas, additional, Haug, Joanna, additional, Ernstoff, Raina, additional, Cao, Jingyang, additional, Chmielewski, Gary, additional, Welsh, Robert, additional, Duris, Robin, additional, Gutmann, Laurie, additional, Pawar, Gauri, additional, Graeber, Geoffrey Marc, additional, Altemus, Patricia, additional, Nance, Christopher, additional, Gutmann, Ludwig, additional, Jackson, Carlayne, additional, Grogan, Patrick, additional, Calhoon, John, additional, Kittrell, Pamela, additional, Myers, Deborah, additional, Hayat, Ghazala, additional, Naunheim, Keith, additional, Eller, Susan, additional, Holzemer, Eve, additional, Alshekhlee, Amer, additional, Robke, Jason, additional, Karlinchak, Brenda, additional, Katz, Jonathan, additional, Miller, Robert, additional, Roan, Ralph, additional, Forshew, Dallas, additional, Kissel, John, additional, Elsheikh, Bakri, additional, Ross, Patrick, additional, Chelnick, Sharon, additional, Lewis, Richard, additional, Acsadi, Agnes, additional, Baciewicz, Frank, additional, Masse, Stacey, additional, Massey, Janice, additional, Juel, Vern, additional, Onaitis, Mark, additional, Lowe, James, additional, Lipscomb, Bernadette, additional, Thai, Gaby, additional, Milliken, Jeffrey, additional, Martin, Veronica, additional, Karayan, Ronnie, additional, Muley, Suraj, additional, Parry, Gareth, additional, Shumway, Sara, additional, Oh, Shin, additional, Claussen, Gwen, additional, Lu, Liang, additional, Cerfolio, Robert, additional, Young, Angela, additional, Morgan, Marla, additional, Pascuzzi, Robert, additional, Kincaid, John, additional, Kesler, Kenneth, additional, Guingrich, Sandy, additional, Michaels, Angi, additional, Phillips, Lawrence, additional, Burns, Ted, additional, Jones, David, additional, Fischer, Cindy, additional, Pulley, Michael, additional, Berger, Alan, additional, D'Agostino, Harry, additional, Smith, Lisa, additional, Rivner, Michael, additional, Pruitt, Jerry, additional, Landolfo, Kevin, additional, Hillman, Demetric, additional, Shaibani, Aziz, additional, Sermas, Angelo, additional, Ruel, Ross, additional, Ismail, Farah, additional, Sivak, Mark, additional, Goldstein, Martin, additional, Camunas, Jorge, additional, Bratton, Joan, additional, Panitch, Hill, additional, Leavitt, Bruce, additional, Jones, Marilee, additional, Muppidi, Srikanth, additional, Vernino, Steven, additional, Nations, Sharon, additional, Meyer, Dan, additional, and Gorham, Nina, additional

Published
2019
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