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Your search keyword '"Herczeg, Iván T."' showing total 4 results
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4 results on '"Herczeg, Iván T."'

1. Local and systemic responses to SARS-CoV-2 infection in children and adults

Author

Yoshida, Masahiro, Worlock, Kaylee B., Huang, Ni, Lindeboom, Rik G. H., Butler, Colin R., Kumasaka, Natsuhiko, Dominguez Conde, Cecilia, Mamanova, Lira, Bolt, Liam, Richardson, Laura, Polanski, Krzysztof, Madissoon, Elo, Barnes, Josephine L., Allen-Hyttinen, Jessica, Kilich, Eliz, Jones, Brendan C., de Wilton, Angus, Wilbrey-Clark, Anna, Sungnak, Waradon, Pett, J. Patrick, Weller, Juliane, Prigmore, Elena, Yung, Henry, Mehta, Puja, Saleh, Aarash, Saigal, Anita, Chu, Vivian, Cohen, Jonathan M., Cane, Clare, Iordanidou, Aikaterini, Shibuya, Soichi, Reuschl, Ann-Kathrin, Herczeg, Iván T., Argento, A. Christine, Wunderink, Richard G., Smith, Sean B., Poor, Taylor A., Gao, Catherine A., Dematte, Jane E., Reynolds, Gary, Haniffa, Muzlifah, Bowyer, Georgina S., Coates, Matthew, Clatworthy, Menna R., Calero-Nieto, Fernando J., Göttgens, Berthold, O’Callaghan, Christopher, Sebire, Neil J., Jolly, Clare, De Coppi, Paolo, Smith, Claire M., Misharin, Alexander V., Janes, Sam M., Teichmann, Sarah A., Nikolić, Marko Z., and Meyer, Kerstin B.

Published
2022
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2. Early human lung immune cell development and its role in epithelial cell fate

Author

Barnes, Josephine L., primary, Yoshida, Masahiro, additional, He, Peng, additional, Worlock, Kaylee B., additional, Lindeboom, Rik G.H., additional, Suo, Chenqu, additional, Pett, J. Patrick, additional, Wilbrey-Clark, Anna, additional, Dann, Emma, additional, Mamanova, Lira, additional, Richardson, Laura, additional, Polanski, Krzysztof, additional, Pennycuick, Adam, additional, Allen-Hyttinen, Jessica, additional, Herczeg, Iván T., additional, Arzili, Romina, additional, Hynds, Robert E., additional, Teixeira, Vitor H., additional, Haniffa, Muzlifah, additional, Lim, Kyungtae, additional, Sun, Dawei, additional, Rawlins, Emma L., additional, Oliver, Amanda J., additional, Lyons, Paul A., additional, Marioni, John C., additional, Ruhrberg, Christiana, additional, Tuong, Zewen Kelvin, additional, Clatworthy, Menna R., additional, Reading, James L., additional, Janes, Sam M., additional, Teichmann, Sarah A., additional, Meyer, Kerstin B., additional, and Nikolić, Marko Z., additional

Published
2023
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3. Early human lung immune cell development and its role in epithelial cell fate

Author

Barnes, Josephine L., primary, He, Peng, additional, Yoshida, Masahiro, additional, Worlock, Kaylee B., additional, Lindeboom, Rik G.H., additional, Suo, Chenqu, additional, Pett, J. Patrick, additional, Wilbrey-Clark, Anna, additional, Dann, Emma, additional, Mamanova, Lira, additional, Richardson, Laura, additional, Oliver, Amanda J., additional, Pennycuick, Adam, additional, Allen-Hyttinen, Jessica, additional, Herczeg, Iván T., additional, Hynds, Robert E., additional, Teixeira, Vitor H., additional, Haniffa, Muzlifah, additional, Lim, Kyungtae, additional, Sun, Dawei, additional, Rawlins, Emma L., additional, Polanski, Krzysztof, additional, Lyons, Paul A., additional, Marioni, John C., additional, Tuong, Zewen Kelvin, additional, Clatworthy, Menna R., additional, Reading, James L., additional, Janes, Sam M., additional, Teichmann, Sarah A., additional, Meyer, Kerstin B., additional, and Nikolić, Marko Z., additional

Published
2022
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4. Local and systemic responses to SARS-CoV-2 infection in children and adults

Author

Gottgens, Berthold, Yoshida, Masahiro, Worlock, Kaylee, Yoshida, Masahiro [0000-0002-3521-5322], Worlock, Kaylee B [0000-0002-5656-7634], Lindeboom, Rik GH [0000-0002-3660-504X], Kumasaka, Natsuhiko [0000-0002-3557-0375], Dominguez Conde, Cecilia [0000-0002-8684-4655], Mamanova, Lira [0000-0003-1463-8622], Bolt, Liam [0000-0001-7293-0774], Richardson, Laura [0000-0002-8075-3816], Polanski, Krzysztof [0000-0002-2586-9576], Barnes, Josephine L [0000-0001-9938-3176], Allen-Hyttinen, Jessica [0000-0003-4644-0362], Jones, Brendan C [0000-0002-2637-8859], Sungnak, Waradon [0000-0002-0136-4960], Pett, J Patrick [0000-0002-5249-444X], Weller, Juliane [0000-0002-1310-6168], Prigmore, Elena [0000-0001-8870-0316], Chu, Vivian [0000-0003-1376-1186], Cohen, Jonathan M [0000-0003-1004-5598], Cane, Clare [0000-0002-3545-768X], Shibuya, Soichi [0000-0002-4274-1312], Herczeg, Iván T [0000-0003-1281-3634], Wunderink, Richard G [0000-0002-8527-4195], Gao, Catherine A [0000-0001-5576-3943], Reynolds, Gary [0000-0002-8142-8708], Haniffa, Muzlifah [0000-0002-3927-2084], Bowyer, Georgina S [0000-0002-2058-4045], Calero-Nieto, Fernando J [0000-0003-3358-8253], Göttgens, Berthold [0000-0001-6302-5705], Jolly, Clare [0000-0002-4603-2281], De Coppi, Paolo [0000-0002-1659-0207], Smith, Claire M [0000-0002-8913-0009], Misharin, Alexander V [0000-0003-2879-3789], Janes, Sam M [0000-0002-6634-5939], Teichmann, Sarah A [0000-0002-6294-6366], Nikolić, Marko Z [0000-0001-6304-6848], Meyer, Kerstin B [0000-0001-5906-1498], and Apollo - University of Cambridge Repository

Subjects
Cambridge Stem Cell Institute
Abstract

It is not fully understood why COVID-19 is typically milder in children To examine differences in response to SARS-CoV-2 infection in children and adults, we analysed paediatric and adult COVID-19 patients and healthy controls (total n=93) using single-cell multi-omic profiling of matched nasal, tracheal, bronchial and blood samples. In healthy paediatric airways, we observed cells already in an interferon-activated state, that upon SARS-CoV-2 infection was further induced especially in airway immune cells. We postulate that higher paediatric innate interferon-responses restrict viral replication and disease progression. The systemic response in children was characterised by increases in naive lymphocytes and a depletion of natural killer cells, while in adults cytotoxic T cells and interferon-stimulated subpopulations were significantly increased. We provide evidence that dendritic cells initiate interferon signaling in early infection, and identify novel epithelial cell states that associate with COVID-19 and age. Our matching nasal and blood data showed a strong interferon response in the airways with the induction of systemic interferon-stimulated populations, which were massively reduced in paediatric patients. Together, we provide several mechanisms that explain the milder clinical syndrome observed in children.

Published
2022

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