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148 results on '"Herdener M"'

1. Clinical potential of methylphenidate in the treatment of cocaine addiction: a review of the current evidence

Author

Dürsteler KM, Berger EM, Strasser J, Caflisch C, Mutschler J, Herdener M, and Vogel M

Subjects
Public aspects of medicine, RA1-1270
Abstract

Kenneth M Dürsteler,1,2 Eva-Maria Berger,1 Johannes Strasser,1 Carlo Caflisch,2 Jochen Mutschler,2 Marcus Herdener,2 Marc Vogel1 1Center for Addictive Disorders, Psychiatric University Clinics Basel, Basel, Switzerland; 2Center for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland Background: Cocaine use continues to be a public health problem, yet there is no proven effective pharmacotherapy for cocaine dependence. A promising approach to treating cocaine dependence may be agonist-replacement therapy, which is already used effectively in the treatment of opioid and tobacco dependence. The replacement approach for cocaine dependence posits that administration of a long-acting stimulant medication should normalize the neurochemical and behavioral perturbations resulting from chronic cocaine use. One potential medication to be substituted for cocaine is methylphenidate (MPH), as this stimulant possesses pharmacobehavioral properties similar to those of cocaine. Aim: To provide a qualitative review addressing the rationale for the use of MPH as a cocaine substitute and its clinical potential in the treatment of cocaine dependence. Methods: We searched MEDLINE for clinical studies using MPH in patients with cocaine abuse/dependence and screened the bibliographies of the articles found for pertinent literature. Results: MPH, like cocaine, increases synaptic dopamine by inhibiting dopamine reuptake. The discriminative properties, reinforcing potential, and subjective effects of MPH and cocaine are almost identical and, importantly, MPH has been found to substitute for cocaine in animals and human volunteers under laboratory conditions. When taken orally in therapeutic doses, its abuse liability, however, appears low, which is especially true for extended-release MPH preparations. Though there are promising data in the literature, mainly from case reports and open-label studies, the results of randomized controlled trials have been disappointing so far and do not corroborate the use of MPH as a substitute for cocaine dependence in patients without attention deficit hyperactivity disorder. Conclusion: Clinical studies evaluating MPH substitution for cocaine dependence have provided inconsistent findings. However, the negative findings may be explained by specific study characteristics, among them dosing, duration of treatment, or sample size. This needs to be considered when discussing the potential of MPH as replacement therapy for cocaine dependence. Finally, based on the results, we suggest possible directions for future research. Keywords: agonist replacement, dependence, substitution

Published
2015

7. N-acetylcysteine modulates prefrontal response to cocaine cues

Author

Engeli, E., primary, Preller, K.H., additional, Rieser, N.M., additional, Klar, J., additional, Zoelch, N., additional, Hock, A., additional, Staempfli, P., additional, Hulka, L.M., additional, Kirschner, M., additional, Seifritz, E., additional, Quednow, B.B., additional, and Herdener, M., additional

Published
2023
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12. Kokain

Author

Quednow, Boris B, Herdener, M, University of Zurich, Soyka, M, Batra, A, Heinz, A, Moggi, F, and Walter, M

Subjects
10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 610 Medicine & health
Published
2018

13. Cannabis use in Switzerland 2015–2045: A population survey based model

Author

Vogel, Marc, Nordt, C; https://orcid.org/0000-0002-1156-152X, Bitar, Raoul, Boesch, Lukas, Walter, M, Dürsteler, Kenneth M, Herdener, Marcus; https://orcid.org/0000-0001-5830-1971, Vogel, M ( Marc ), Nordt, C ( C ), Bitar, R ( Raoul ), Boesch, L ( Lukas ), Walter, M ( M ), Dürsteler, K M ( Kenneth M ), Herdener, M ( Marcus ), Nordt, Carlos, Walter, Marc, Seifritz, Erich, Herdener, Marcus, Vogel, Marc, Nordt, C; https://orcid.org/0000-0002-1156-152X, Bitar, Raoul, Boesch, Lukas, Walter, M, Dürsteler, Kenneth M, Herdener, Marcus; https://orcid.org/0000-0001-5830-1971, Vogel, M ( Marc ), Nordt, C ( C ), Bitar, R ( Raoul ), Boesch, L ( Lukas ), Walter, M ( M ), Dürsteler, K M ( Kenneth M ), Herdener, M ( Marcus ), Nordt, Carlos, Walter, Marc, Seifritz, Erich, and Herdener, Marcus

Abstract

Background Alternative cannabis regulation models are discussed and implemented worldwide. A baseline scenario under the assumption of no policy or market changes may prove useful to forecast cannabis use and treatment demand and evaluate changes in legislation. Methods Based on data of the Continuous Rolling Survey of Addictive Behaviours and Related Risks on cannabis use, age, gender and nationality from 2011 to 2015, we used general estimating equation analysis to model lifetime and 30-days prevalence from 2015 to 2045 in Switzerland accounting for demographic trends. Results Lifetime prevalence of cannabis use is projected to grow from 28.3% (CI 95% 27.8–28.8) in 2015 to 42.0% (CI 95% 41.0–43.0) in 2045. 30-days prevalence would increase slightly from 2.70% (CI 95% 2.53–2.88) to 3.39% (CI 95% 3.11–3.66). Due to population growth, absolute numbers with past 30-day cannabis use are estimated to increase from 202,784 (CI 95% 189,534–216,035) to 314,302 (CI 95% 288,504–340,100). Among those aged under 30 years no substantial change in lifetime and 30-days prevalence of cannabis use is projected. Larger changes are estimated to occur in the age group 30+. The mean age of past 30-day cannabis users would increase for men with Swiss nationality from 30.3 to 38.7 years. Discussion Population-based survey data and demographic projections can be used to develop baseline scenarios of future cannabis use. Assuming no changes in cannabis legislation, growing absolute numbers of users will likely increase treatment demand. Cannabis use is estimated to increase among the group aged >30 years, which is currently underrepresented in clinical treatment and research. Our findings highlight the need for prospective baseline scenarios to evaluate the impact of legislative changes on cannabis use. Moreover, in Switzerland effective prevention and treatment interventions for cannabis use disorders are required even if cannabis legislation remains unchanged.

Published
2019

15. Kokain

Author

Soyka, M, Batra, A, Heinz, A, Moggi, F, Walter, M, Soyka, M ( M ), Batra, A ( A ), Heinz, A ( A ), Moggi, F ( F ), Walter, M ( M ), Quednow, Boris B; https://orcid.org/0000-0001-7933-2865, Herdener, M, Soyka, M, Batra, A, Heinz, A, Moggi, F, Walter, M, Soyka, M ( M ), Batra, A ( A ), Heinz, A ( A ), Moggi, F ( F ), Walter, M ( M ), Quednow, Boris B; https://orcid.org/0000-0001-7933-2865, and Herdener, M

Published
2018

16. Endogenous cortisol in keratinized matrices: systematic determination of baseline cortisol levels in hair and the influence of sex, age and hair color

Author

Binz, T M; https://orcid.org/0000-0001-6783-1202, Rietschel, L, Streit, F, Hofmann, M, Gehrke, J, Herdener, M, Quednow, B B; https://orcid.org/0000-0001-7933-2865, Martin, N G, Rietschel, M, Kraemer, T, Baumgartner, M R; https://orcid.org/0000-0002-0979-931X, Binz, T M; https://orcid.org/0000-0001-6783-1202, Rietschel, L, Streit, F, Hofmann, M, Gehrke, J, Herdener, M, Quednow, B B; https://orcid.org/0000-0001-7933-2865, Martin, N G, Rietschel, M, Kraemer, T, and Baumgartner, M R; https://orcid.org/0000-0002-0979-931X

Published
2018

31. Neural correlates of pre-attentive processing of pattern deviance in professional musicians

Author

Habermeyer, B, Herdener, M, Esposito, F, Hilti, C C, Klarhöfer, M, Di Salle, F, Wetzel, S, Scheffler, K, University of Zurich, and Habermeyer, B

Subjects
2728 Neurology (clinical), Radiological and Ultrasound Technology, Neurology, Radiology Nuclear Medicine and imaging, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 2808 Neurology, Clinical Neurology, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, Anatomy, 2702 Anatomy, 3614 Radiological and Ultrasound Technology
Published
2009
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36. Jazz drummers recruit language-specific areas for the processing of rhythmic structure

Author

Herdener, M, Humbel, T, Esposito, F, Habermeyer, B, Cattapan-Ludewig, K, Seifritz, E, Herdener, M, Humbel, T, Esposito, F, Habermeyer, B, Cattapan-Ludewig, K, and Seifritz, E

Abstract

Rhythm is a central characteristic of music and speech, the most important domains of human communication using acoustic signals. Here, we investigated how rhythmical patterns in music are processed in the human brain, and, in addition, evaluated the impact of musical training on rhythm processing. Using fMRI, we found that deviations from a rule-based regular rhythmic structure activated the left planum temporale together with Broca's area and its right-hemispheric homolog across subjects, that is, a network also crucially involved in the processing of harmonic structure in music and the syntactic analysis of language. Comparing the BOLD responses to rhythmic variations between professional jazz drummers and musical laypersons, we found that only highly trained rhythmic experts show additional activity in left-hemispheric supramarginal gyrus, a higher-order region involved in processing of linguistic syntax. This suggests an additional functional recruitment of brain areas usually dedicated to complex linguistic syntax processing for the analysis of rhythmical patterns only in professional jazz drummers, who are especially trained to use rhythmical cues for communication.

Published
2014

40. Coding of melodic gestalt in human auditory cortex

Author

Schindler, A, Herdener, M, Bartels, A, Schindler, A, Herdener, M, and Bartels, A

Abstract

The perception of a melody is invariant to the absolute properties of its constituting notes, but depends on the relation between them—the melody's relative pitch profile. In fact, a melody's “Gestalt” is recognized regardless of the instrument or key used to play it. Pitch processing in general is assumed to occur at the level of the auditory cortex. However, it is unknown whether early auditory regions are able to encode pitch sequences integrated over time (i.e., melodies) and whether the resulting representations are invariant to specific keys. Here, we presented participants different melodies composed of the same 4 harmonic pitches during functional magnetic resonance imaging recordings. Additionally, we played the same melodies transposed in different keys and on different instruments. We found that melodies were invariantly represented by their blood oxygen level–dependent activation patterns in primary and secondary auditory cortices across instruments, and also across keys. Our findings extend common hierarchical models of auditory processing by showing that melodies are encoded independent of absolute pitch and based on their relative pitch profile as early as the primary auditory cortex.

Published
2013

46. Behandlung der Kokainabhängigkeit.

Author

Herdener, M., Oppliger, R., Stohler, R., and Caflisch, C.

Subjects
*COCAINE abuse, *DRUG abuse treatment, *DISEASE prevalence, *PHARMACOLOGY, *PSYCHOTHERAPISTS
Abstract

Estimates assume approximately 100 000 occasional and 11 000 addicted cocaine consumers in Switzerland. Although there is no established «standard Treatment», helpful pharmacological and psychotherapeutic treatment strategies for cocaine addiction and its consequences exist. A selection of the most relevant treatment options is presented in this review. Their application should be embedded within an individualized treatment plan, which usually includes several of the therapeutic elements presented hereafter, depending on the patient's current situation. The treatment of patients with cocaine dependence might encompass longer periods and multiple sequences of treatment in out- or inpatient setting, yet it is promising. [ABSTRACT FROM AUTHOR]

Published
2012
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49. Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction

Author

Niklaus Zoelch, Andreas Hock, Etna J.E. Engeli, Fabrizio Esposito, Erich Seifritz, Carlos Nordt, Anke Henning, Lea M. Hulka, Matthias Kirschner, Markus R. Baumgartner, Milan Scheidegger, Boris B. Quednow, Marcus Herdener, Engeli, E. J. E., Zoelch, N., Hock, A., Nordt, C., Hulka, L. M., Kirschner, M., Scheidegger, M., Esposito, F., Baumgartner, M. R., Henning, A., Seifritz, E., Quednow, B. B., Herdener, M., University of Zurich, and Engeli, Etna J E

Subjects
0301 basic medicine, media_common.quotation_subject, Drug-Seeking Behavior, 2804 Cellular and Molecular Neuroscience, Glutamic Acid, Craving, 610 Medicine & health, Self Administration, Nucleus accumbens, Pharmacology, Nucleus Accumbens, 03 medical and health sciences, Glutamatergic, Basal (phylogenetics), 2738 Psychiatry and Mental Health, Cellular and Molecular Neuroscience, Cocaine-Related Disorders, 0302 clinical medicine, Glutamate homeostasis, Cocaine, mental disorders, 1312 Molecular Biology, Medicine, Animals, Homeostasis, Humans, 10237 Institute of Biomedical Engineering, 10064 Neuroscience Center Zurich, Molecular Biology, media_common, business.industry, Addiction, Glutamate receptor, 10218 Institute of Legal Medicine, Psychiatry and Mental health, 030104 developmental biology, Potential biomarkers, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 10076 Center for Integrative Human Physiology, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Cocaine addiction is characterized by overwhelming craving for the substance, which drives its escalating use despite adverse consequences. Animal models suggest a disrupted glutamate homeostasis in the nucleus accumbens to underlie addiction-like behavior. After chronic administration of cocaine, rodents show decreased levels of accumbal glutamate, whereas drug-seeking reinstatement is associated with enhanced glutamatergic transmission. However, due to technical obstacles, the role of disturbed glutamate homeostasis for cocaine addiction in humans remains only partially understood, and accordingly, no approved pharmacotherapy exists. Here, we applied a tailored proton magnetic resonance spectroscopy protocol that allows glutamate quantification within the human nucleus accumbens. We found significantly reduced basal glutamate concentrations in the nucleus accumbens in cocaine-addicted (N = 26) compared with healthy individuals (N = 30), and increased glutamate levels during cue-induced craving in cocaine-addicted individuals compared with baseline. These glutamatergic alterations, however, could not be significantly modulated by a short-term challenge of N-acetylcysteine (2400 mg/day on 2 days). Taken together, our findings reveal a disturbed accumbal glutamate homeostasis as a key neurometabolic feature of cocaine addiction also in humans. Therefore, we suggest the glutamatergic system as a promising target for the development of novel pharmacotherapies, and in addition, as a potential biomarker for a personalized medicine approach in addiction.

Published
2021
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50. Jazz Drummers Recruit Language-Specific Areas for the Processing of Rhythmic Structure

Author

Marcus Herdener, Fabrizio Esposito, Benedikt Habermeyer, Erich Seifritz, Thierry Humbel, Katja Cattapan-Ludewig, Cognitive Neuroscience, RS: FPN CN 1, University of Zurich, and Herdener, M

Subjects
2805 Cognitive Neuroscience, Adult, Male, Periodicity, Cognitive Neuroscience, Planum temporale, neuroplasticity, 2804 Cellular and Molecular Neuroscience, 610 Medicine & health, Musical, 10056 Clinic for Clinical and Social Psychiatry Zurich West (former), behavioral disciplines and activities, Functional Laterality, Young Adult, Cellular and Molecular Neuroscience, Rhythm, Supramarginal gyrus, Image Processing, Computer-Assisted, Humans, auditory processing, Human communication, Language, Brain Mapping, Communication, training, business.industry, Musical syntax, fMRI, Brain, Middle Aged, Magnetic Resonance Imaging, Syntax, humanities, Oxygen, Acoustic Stimulation, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Auditory Perception, Jazz, Psychology, business, Music, Psychomotor Performance
Abstract

Rhythm is a central characteristic of music and speech, the most important domains of human communication using acoustic signals. Here, we investigated how rhythmical patterns in music are processed in the human brain, and, in addition, evaluated the impact of musical training on rhythm processing. Using fMRI, we found that deviations from a rule-based regular rhythmic structure activated the left planum temporale together with Broca's area and its right-hemispheric homolog across subjects, that is, a network also crucially involved in the processing of harmonic structure in music and the syntactic analysis of language. Comparing the BOLD responses to rhythmic variations between professional jazz drummers and musical laypersons, we found that only highly trained rhythmic experts show additional activity in left-hemispheric supramarginal gyrus, a higher-order region involved in processing of linguistic syntax. This suggests an additional functional recruitment of brain areas usually dedicated to complex linguistic syntax processing for the analysis of rhythmical patterns only in professional jazz drummers, who are especially trained to use rhythmical cues for communication.

Published
2017
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