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Creative economy is the area of knowledge that explores the intangible and symbolic aspects and feeds on creative talents, individually and/or collectively organized, in order to produce creative goods and services. This type of economy has its own dynamics, and it disturbs the traditional economic models. This study investigated creative economy comprehensively and aims to analyze the critical factors inherent in the dynamics of creative economy for regional development, considering the helix model of innovation (quintuple helix innovation model), aligned with entrepreneurship and innovation. To this end, the methodology used was systematized exploratory research, treated within three dimensions – the economic-financial, the socio-anthropological, and the techno-innovative. The conclusion of the study was the identification of fifteen critical factors, the direct creative economy relationship with the quintuple helix innovation model in all its helixes, as well as its “Mode 3” of the dynamics of knowledge generation, creation, and dissemination. The study also highlighted the importance of creative economy as one of the “engines” of regional development, in an economic, financial, social, technological, and sustainable way, driven by the government, its networks, and its actors.

The talent and artistic characteristics of these entrepreneurs can create ecosystems of cultural innovation, as there is an effervescent creativity that can and should be used in favor of the territory. This connection can mitigate psychological and social problems, activating community belonging and offering visibility to culture makers. This study aims to investigate the contributions of microenterprises in the field of culture to regional development in the metropolitan region of Rio de Janeiro. These developments contribute to the economic and social balance of the territory; leveraging existing cultural resources, offering belonging and income to the local community. A systematic review was carried out divided into two stages, first in the formation of the bibliographic portfolio and in the results extracted from the procedure, then the connection between regional development and culture was analyzed. Three indexed databases were used, the Web of Science, SciELO and Scopus, with the search period between 2001 and 2021, which underwent 102 articles after the eligibility process. It was noticed that the link between the keywords “cultural entrepreneurship” and “regional development” was little interned in magazines that were more protective of the debate in the world; however, there was an important scientific gap for the academic debate, such as the transversality that culture is capable of generate from your products and services. [ABSTRACT FROM AUTHOR]