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3. Serum and tissue levels of cefoxitin in perioperative prophylaxis.

Author

Herlitz, V., Langmaack, H., Metzger, M., and Daschner, F. D.

Abstract

In 31 patients, the antibiotic concentrations in serum, muscle and fat at various times after intravenous bolus injections of 2 g cefoxitin were determined by an agar diffusion method. The serum levels were described by a two-compartment open model, and the tissue levels were described by a one-compartment model. The attainable concentrations were compared with the inhibitory action on various pathogenic organisms, and suggestions are given as to the dosage in perioperative antibiotic prophylaxis. [ABSTRACT FROM PUBLISHER]

Published
1980

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