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* Problem Statement: Soccer players expose themselves to repetitive head impacts (RHI) by purposefully heading the ball - an act that has been suggested to adversely affect brain structure and function and potentially contribute to the long-term development of neurodegenerative disorders. A deeper understanding of the head's kinematic response to these RHI is crucial to assess the actual risk resulting from routine soccer heading. To that aim, we investigated the influence of a comprehensive set of heading-related factors on the resulting linear and rotational acceleration of the head, as obtained by wearable sensors in a field study. * Methods: Across 26 matches, 19 semi-professional female soccer players (23.0±3.7 years) were equipped with wearable head impact sensors that registered peak linear acceleration (PLA) and peak rotational acceleration (PRA) of on-field head impact events. Actual headers were confirmed and further allocated to the following categories using video analyses: Scenario, Distance, Player Movement, Ball Reflection, Impact Location, Duel, Jump. Linear mixed models were used to assess the relationships between these factors and PLA as well as PRA. * Results: Average PLA and PRA of the head due to heading was 29.6 (±18.1) g and 6195.6 (±4448.1) rad/s², respectively. Analyses revealed a statistically significant influence of three factors on both PLA (R2=0.34) and PRA (R2=0.37). Next to subject-related factors (p<0.001; proportional variance: 12.6% [PLA] and 19.0% [PRA]), especially longer in-air distances of the ball prior to heading (p<0.001; proportional variance: 24.6% [PLA] and 19.2% [PRA]) as well as a greater extent of ball reflection due to a header (p<0.001; proportional variance: 9.2% [PLA] and 6.9% [PRA]) were significantly associated with increases in head impact kinematics. * Conclusion: Our findings demonstrate that the ball's travelling distance and the extent of ball reflection due to a header directly affect the head's kinematic response to purposeful headers in female players. Along with these factors, future studies should focus on the direct assessment of inter-individual differences in heading technique and anthropometric variables to increase the current understanding of the potential risk resulting from RHI due to soccer heading. [ABSTRACT FROM AUTHOR]

Background/Objectives: Evidence regarding the effect of n-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation during pregnancy on offspring's neurodevelopment is not conclusive. Subjects/Methods: In this analysis, the effect of a reduced n-6:n-3 LCPUFA ratio in the diet of pregnant/lactating women (1.2 g n-3 LCPUFA together with an arachidonic acid (AA)-balanced diet between 15th wk of gestation-4 months postpartum vs control diet) on child neurodevelopment at 4 and 5 years of age was assessed. A child development inventory (CDI) questionnaire and a hand movement test measuring mirror movements (MMs) were applied and the association with cord blood LCPUFA concentrations examined. Results: CDI questionnaire data, which categorizes children as 'normal', 'borderline' or 'delayed' in different areas of development, showed no significant evidence between study groups at 4 (n=119) and 5 years (n=130) except for the area 'letters' at 5 years of age (P=0.043). Similarly, the results did not strongly support the hypothesis that the intervention has a beneficial effect on MMs (for example, at 5 years: dominant hand, fast: adjusted mean difference, -0.08 (-0.43, 0.26); P=0.631). Children exposed to higher cord blood concentrations of docosahexaenoic acid, eicosapentaenoic acid and AA, as well as a lower ratio of n-6:n-3 fatty acids appeared to show beneficial effects on MMs, but these results were largely not statistically significant. Conclusions: Our results do not show clear benefits or harms of a change in the n-6:n-3 LCPUFA ratio during pregnancy on offspring's neurodevelopment at preschool age. Findings on cord blood LCPUFAs point to a potential influence on offspring development., Author(s): C Brei [sup.1] , L Stecher [sup.1] , S Brunner [sup.1] , R Ensenauer [sup.2] [sup.3] , F Heinen [sup.4] , P D Wagner [sup.5] , J Hermsdörfer [sup.5] [...]