1. The Benefit of Nocturnal IOP Reduction in Glaucoma, Including Normal Tension Glaucoma
- Author
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Huang AS, Mai AP, Goldberg JL, Samuelson TW, Morgan WH, Herndon L, Ferguson TJ, and Weinreb RN
- Subjects
glaucoma ,nocturnal intraocular pressure ,translaminar pressure differential ,Ophthalmology ,RE1-994 - Abstract
Alex S Huang,1 Anthony P Mai,2 Jeffrey L Goldberg,3 Thomas W Samuelson,4 William H Morgan,5 Leon Herndon,6 Tanner J Ferguson,2 Robert N Weinreb7 1Doheny Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Vance Thompson Vision, Sioux Falls, SD, USA; 3Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA; 4Minnesota Eye Consultants, University of Minnesota, Minneapolis, MN, USA; 5Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia; 6Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC, USA; 7Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, USACorrespondence: Anthony P Mai, Email anthonymai.md@gmail.comAbstract: Nocturnal intraocular pressure (IOP) profiling has shown that the peak IOP usually occurs at night, particularly in patients with glaucoma. Multiple studies have demonstrated that these nocturnal IOP elevations drive glaucomatous progression, often despite stable daytime IOP. Existing vascular dysregulation and decreased nighttime blood pressure compound the damage via low ocular perfusion pressure while elevated nocturnal IOP disrupts axonal transport. These findings are consistent with studies that indicate lowering nocturnal IOP is important for slowing glaucoma progression. Many of the current treatment options lower nighttime IOP significantly less than daytime IOP. Non-invasive IOP-lowering treatments that effectively lower nocturnal IOP remain an unmet need in the treatment of glaucoma.Keywords: glaucoma, nocturnal intraocular pressure, translaminar pressure differential
- Published
- 2024