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2. Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

Author

Knecht, Henrik, Reigl, Tomas, Kotrová, Michaela, Appelt, Franziska, Stewart, Peter, Bystry, Vojtech, Krejci, Adam, Grioni, Andrea, Pal, Karol, Stranska, Kamila, Plevova, Karla, Rijntjes, Jos, Songia, Simona, Svatoň, Michael, Froňková, Eva, Bartram, Jack, Scheijen, Blanca, Herrmann, Dietrich, García-Sanz, Ramón, Hancock, Jeremy, Moppett, John, van Dongen, Jacques J. M., Cazzaniga, Giovanni, Davi, Frédéric, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Trka, Jan, Langerak, Anton W., Gonzalez, David, Pott, Christiane, Brüggemann, Monika, Darzentas, Nikos, and on behalf of the EuroClonality-NGS Working Group

Published
2019
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3. Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

Author

Brüggemann, Monika, Kotrová, Michaela, Knecht, Henrik, Bartram, Jack, Boudjogrha, Myriam, Bystry, Vojtech, Fazio, Grazia, Froňková, Eva, Giraud, Mathieu, Grioni, Andrea, Hancock, Jeremy, Herrmann, Dietrich, Jiménez, Cristina, Krejci, Adam, Moppett, John, Reigl, Tomas, Salson, Mikael, Scheijen, Blanca, Schwarz, Martin, Songia, Simona, Svaton, Michael, van Dongen, Jacques J. M., Villarese, Patrick, Wakeman, Stephanie, Wright, Gary, Cazzaniga, Giovanni, Davi, Frédéric, García-Sanz, Ramón, Gonzalez, David, Groenen, Patricia J. T. A., Hummel, Michael, Macintyre, Elizabeth A., Stamatopoulos, Kostas, Pott, Christiane, Trka, Jan, Darzentas, Nikos, Langerak, Anton W., and on behalf of the EuroClonality-NGS working group

Published
2019
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6. Einführung

Author

Vorländer, Hans, Herrmann, Dietrich, Vorländer, Hans, and Herrmann, Dietrich

Published
2001
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9. Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display

Author

Krohn, Steffen, primary, Boje, Ammelie Svea, additional, Gehlert, Carina Lynn, additional, Lutz, Sebastian, additional, Darzentas, Nikos, additional, Knecht, Henrik, additional, Herrmann, Dietrich, additional, Brüggemann, Monika, additional, Scheidig, Axel J., additional, Weisel, Katja, additional, Gramatzki, Martin, additional, Peipp, Matthias, additional, and Klausz, Katja, additional

Published
2022
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16. The IG/TR Next Generation Marker Screening Developed within Euroclonality-NGS Consortium Is Successful in 94% of Acute Lymphoblastic Leukemia Samples

Author

Kotrova, Michaela, primary, Knecht, Henrik, additional, Herrmann, Dietrich, additional, Schwarz, Martin, additional, Olsen, Karin, additional, Trautmann, Heiko, additional, Goekbuget, Nicola, additional, Pott, Christiane, additional, Darzentas, Nikos, additional, and Brüggemann, Monika, additional

Published
2018
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18. T-Prolymphocytic Leukemia Is Sensitive to Polyclonal T Cell-Derived Graft-Versus-Leukemia Effects: Evidence from Minimal Residual Disease Kinetics and TCR Repertoire Diversity Analyses

Author

Sellner, Leopold, primary, Dreger, Peter, additional, Schlitt, Max, additional, Knecht, Henrik, additional, Herrmann, Dietrich, additional, Reigl, Thomas, additional, Krejci, Adam, additional, Bystry, Vojtech, additional, Darzentas, Nikos, additional, Rieger, Michael, additional, Dietrich, Sascha, additional, Zenz, Thorsten, additional, Ho, Anthony D., additional, Kneba, Michael, additional, and Brueggemann, Monika, additional

Published
2015
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19. Library Preparation Is the Major Factor Affecting Differences in Results of Immunoglobulin Gene Rearrangements Detection on Two Major Next-Generation Sequencing Platforms

Author

Kotrova, Michaela, primary, Knecht, Henrik, additional, Bartram, Jack, additional, Bystry, Vojtech, additional, Cazzaniga, Giovanni, additional, Fazio, Grazia, additional, Ferrero, Simone, additional, Genuardi, Elisa, additional, Garcia-Sanz, Ramon, additional, Grioni, Andrea, additional, Hancock, Jeremy, additional, Jiminez, Cristina, additional, Ladetto, Marco, additional, Moppett, John, additional, Songia, Simona, additional, Herrmann, Dietrich, additional, Pott, Christiane, additional, Langerak, Anton W., additional, Darzentas, Nikos, additional, Trka, Jan, additional, Fronkova, Eva, additional, and Bruggemann, Monika, additional

Published
2015
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22. Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma

Author

Georg Wick, Roswitha Sgonc, Richard L. Boyd, Herrmann Dietrich, G. Krömer, Matthias S. Gruschwitz, Susanne Moormann, M. Eric Gershwin, and Günther Boeck

Subjects
Interleukin 2, Pathology, medicine.medical_specialty, T cell, CD3, Immunology, Thymus Gland, Peripheral blood mononuclear cell, Antigen, Cell Movement, medicine, Animals, Immunology and Allergy, Lymphocytes, Poultry Diseases, B cell, Skin, Immunity, Cellular, Scleroderma, Systemic, biology, Papillary dermis, T lymphocyte, Flow Cytometry, Hematopoietic Stem Cells, Lymphocyte Subsets, Disease Models, Animal, medicine.anatomical_structure, biology.protein, Chickens, Spleen, medicine.drug
Abstract

University of California at Davis line 200 (UCD-200) chickens develop a hereditary connective tissue disease characterized by severe lymphocytic infiltration, vascular occlusion and fibrosis of skin and internal organs. To identify cellular immunological abnormalities in the acute inflammatory disease stage of this animal model for progressive systemic sclerosis (PSS) we investigated the phenotypic characteristics and function of peripheral blood lymphocytes (PBL), spleen cells and thymocytes in comparison with skin infiltrating cells. Immunofluorescence and immunohistochemical analysis using monoclonal antibodies revealed the overwhelming majority of skin infiltrating mononuclear cells in the deeper dermis and subcutaneous tissue to be T cell receptor alpha/beta (TcR2)+/CD3+/CD4+/class II+ cells, a small portion (5-10%) of which were interleukin 2 (IL-2) receptor positive. In contrast, the inflammatory infiltrate in perivascular areas of the papillary dermis was constituted of mainly TcR gamma/delta (TcR1)+/class II- lymphocytes. Only few B cells (T/B cell ratio greater than 5) were detected. These diseased chickens showed significantly reduced percentages and numbers of circulating peripheral T cells exhibiting TcR1, TcR2, CD3, CD4 or IL-2-receptor, probably owing to an increased influx into lymphoid organs and affected tissues. In contrast to healthy chickens, the thymi of UCD-200 animals revealed fewer cells expressing TcR1, TcR2 and class II antigen, suggesting an altered intrathymic maturation of the T cell lineage. Functional in vitro studies showed a significantly decreased T cell mitogen-induced proliferation rate associated with a decreased capacity to produce IL-2 and to express IL-2 receptors. In contrast to the deficient in vitro IL-2 production the sera of UCD-200 chickens contained significant levels of IL-2 bioactivity. The alteration of T lymphocyte physiology in UCD-200 chickens adds, at least in part, to the parallels between this animal model and its human counterpart. These data confirm our hypothesis that the PSS-like disease of UCD-200 chickens includes a numeric and/or functional alteration of peripheral T cell subsets, especially of TcR1 positive cells, in contrast to the pronounced accumulation in the afflicted tissues.

Published
1991

24. Integrated Somatic Mutation and DNA Methylation Analysis Reveal Genomic and Epigenomic Co-Evolution In Follicular Lymphomas

Author

Loeffler, Markus, primary, Kreuz, Markus, additional, Haake, Andrea, additional, Hasenclever, Dirk, additional, Trautmann, Heiko, additional, Arnold, Christian, additional, Winter, Karsten, additional, Klapper, Wolfram, additional, Scholtysik, René, additional, Rosolowski, Maciej, additional, Hoffmann, Steve, additional, Ammerpohl, Ole, additional, Szczepanowski, Monika, additional, Herrmann, Dietrich, additional, Kueppers, Ralf, additional, Pott, Christiane, additional, and Siebert, Reiner, additional

Published
2013
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28. ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.

Author

Bystry, Vojtech, Reigl, Tomas, Krejci, Adam, Demko, Martin, Hanakova, Barbora, Grioni, Andrea, Knecht, Henrik, Schlitt, Max, Dreger, Peter, Sellner, Leopold, Herrmann, Dietrich, Pingeon, Marine, Boudjoghra, Myriam, Rijntjes, Jos, Pott, Christiane, Langerak, Anton W., Groenen, Patricia J. T. A., Davi, Frederic, Brüggemann, Monika, and Darzentas, Nikos

Subjects
IMMUNOGLOBULINS, T cell receptors, NUCLEOTIDE sequencing, WEB-based user interfaces, IMMUNOGENETICS, STOCHASTIC processes
Abstract

Motivation: The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task. Results: We thus implemented ARResT/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations. [ABSTRACT FROM AUTHOR]

Published
2017
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33. Self-Assertion of Constitutional Courts in Comparative Perspective: France, USA, and Germany.

Author

Herrmann, Dietrich

Subjects
*CONSTITUTIONAL courts, *JUDICIAL power, *JUDICIAL review, *CONSTITUTIONAL law
Abstract

The paper will address the question how constitutional courts attain the authority they have. Some constitutions (as the German Grundgesetz) endow the constitutional court with the explicit authority to decide upon the constitutionality of legal acts and executive practices. In other countries, courts have asserted this authority by acts of self-authorization or self-empowerment. At one point, constitutional courts claim the authority for judicial review and thus emancipate themselves from the original authors of the respective constitution. These assertions in turn may or may not be met by acceptance of other actors in the polity. This acceptance or "ratification" is crucial to the functioning of judicial review as constitutional courts have neither influence on the sword nor the purse (Fed. 78). The paper analyzes the processes of these (repeated) acts of self-authorization and the processes of acceptance or rejection of these assertions by the actors competing for the authority to interpret and enforce the constitution. ..PAT.-Unpublished Manuscript [ABSTRACT FROM AUTHOR]

Published
2007

34. Zwischen Fremde und Fremde (Book).

Author

Herrmann, Dietrich

Subjects
*EMIGRATION & immigration, *NONFICTION
Abstract

Reviews the non-fiction book 'Zwischen Fremde und Fremde: Displaced Persons in Australien, den USA and Kanada 1946-1952,' by Henriette Von Holleuffer.

Published
2003
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42. Hegels Begriff der Macht

Author

Göhler, Gerhard, Brodocz, André, editor, Herrmann, Dietrich, editor, Schmidt, Rainer, editor, Schulz, Daniel, editor, and Schulze Wessel, Julia, editor

Published
2014
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