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12 results on '"Herrmann, Markus Karl"'

4. The delineation of target volumes for radiotherapy of lung cancer patients

Author

Vorwerk, Hilke, Beckmann, Gabriele, Bremer, Michael, Degen, Maria, Dietl, Barbara, Fietkau, Rainer, Gsänger, Tammo, Hermann, Robert Michael, Alfred Herrmann, Markus Karl, Höller, Ulrike, van Kampen, Michael, Körber, Wolfgang, Maier, Burkhard, Martin, Thomas, Metz, Michael, Richter, Ronald, Siekmeyer, Birgit, Steder, Martin, Wagner, Daniela, Hess, Clemens Friedrich, Weiss, Elisabeth, and Christiansen, Hans

Published
2009
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8. Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy

Author

Dröge, Leif Hendrik, primary, Weber, Hanne Elisabeth, additional, Guhlich, Manuel, additional, Leu, Martin, additional, Conradi, Lena-Christin, additional, Gaedcke, Jochen, additional, Hennies, Steffen, additional, Herrmann, Markus Karl, additional, Rave-Fränk, Margret, additional, and Wolff, Hendrik Andreas, additional

Published
2015
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9. Comparison of the Micronucleus and Chromosome Aberration Techniques for the Documentationof Cytogenetic Damage in Radiochemotherapy-Treated Patients with Rectal Cancer

Author

Wolff*, Hendrik Andreas, primary, Hennies, Steffen, additional, Herrmann, Markus Karl Alfred, additional, Rave-Fränk, Margret, additional, Eickelmann, David, additional, Virsik, Patricia, additional, Jung, Klaus, additional, Schirmer, Markus, additional, Ghadimi, Michael, additional, Hess, Clemens Friedrich, additional, Hermann, Robert Michael, additional, and Christiansen, Hans, additional

Published
2010
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10. High-Grade Acute Organ Toxicity During Preoperative Radiochemotherapy as Positive Predictor for Complete Histopathologic Tumor Regression in Multimodal Treatment of Locally Advanced Rectal Cancer*

Author

Wolff, Hendrik Andreas, primary, Gaedcke, Jochen, additional, Jung, Klaus, additional, Hermann, Robert Michael, additional, Rothe, Hilka, additional, Schirmer, Markus, additional, Liersch, Torsten, additional, Herrmann, Markus Karl Alfred, additional, Hennies, Steffen, additional, Rave-Fränk, Margret, additional, Hess, Clemens Friedrich, additional, and Christiansen, Hans, additional

Published
2009
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11. Comparison of the micronucleus and chromosome aberration techniques for the documentation of cytogenetic damage in radiochemotherapy-treated patients with rectal cancer.

Author

Wolff*, Hendrik, Hennies, Steffen, Herrmann, Markus, Rave-Fränk, Margret, Eickelmann, David, Virsik, Patricia, Jung, Klaus, Schirmer, Markus, Ghadimi, Michael, Hess, Clemens, Hermann, Robert, Christiansen, Hans, Wolff, Hendrik Andreas, Herrmann, Markus Karl Alfred, Rave-Fränk, Margret, Hess, Clemens Friedrich, and Hermann, Robert Michael

Abstract

Copyright of Strahlentherapie und Onkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011
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12. Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy

Author

Dröge, Leif Hendrik, Weber, Hanne Elisabeth, Guhlich, Manuel, Leu, Martin, Conradi, Lena-Christin, Gaedcke, Jochen, Hennies, Steffen, Herrmann, Markus Karl, Rave-Fränk, Margret, and Wolff, Hendrik Andreas

Subjects
Adult, Male, 3D conformal radiotherapy, Cancer Research, Kaplan-Meier Estimate, Preoperative Care, Genetics, Humans, Rectal cancer, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Acute toxicity, Rectal Neoplasms, Volumetric modulated arc therapy, Chemoradiotherapy, Middle Aged, Combined Modality Therapy, Tumor regression grading, Treatment Outcome, Oncology, Female, Radiotherapy, Intensity-Modulated, Radiotherapy, Conformal, Late toxicity, Research Article
Abstract

Background Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). In a single-center retrospective analysis, we tested whether these advantages may translate into significant clinical benefits. We compared VMAT to conventional 3D conformal radiotherapy (3DCRT) in patients, homogeneously treated according to the control arm of the CAO/ARO/AIO-04 trial. Methods CRT consisted of pelvic irradiation with 50.4/1.8Gy by VMAT (n = 81) or 3DCRT (n = 107) and two cycles of 5-fluorouracil. Standardized total mesorectal excision surgery was performed within 4–6 weeks. The tumor regression grading (TRG) was assessed by the Dworak score. Acute and late toxicity were evaluated via the Common Terminology Criteria for Adverse Events and the Late effects of normal tissues scale, respectively. Side effects greater than or equal to grade 3 were considered high-grade. Results Median follow-up was 18.3 months in the VMAT group and 61.5 months in the 3DCRT group with no differences in TRG between them (p = 0.1727). VMAT treatment substantially reduced high-grade acute and late toxicity, with 5 % versus 20 % (p = 0.0081) and 6 % vs. 22 % (p = 0.0039), respectively. With regard to specific organs, differences were found in skin reaction (p = 0.019) and proctitis (p = 0.0153). Conclusions VMAT treatment in preoperative CRT for LARC showed the potential to substantially reduce high-grade acute and late toxicity. Importantly, we could demonstrate that VMAT irradiation did not impair short-term oncological results. We conclude, that the reduced toxicity after VMAT irradiation may pave the way for more efficient systemic therapies, and hopefully improved patient survival in the multimodal treatment of LARC. Electronic supplementary material The online version of this article (doi:10.1186/s12885-015-1812-x) contains supplementary material, which is available to authorized users.

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