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8 results on '"Herter, Sonja"'

2. Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

Author

Kocher, Daniela, Cao, Lei, Guiho, Romain, Langhammer, Melanie, Lai, Yun-Lu, Becker, Pauline, Hamdi, Hiba, Friedel, Dennis, Selt, Florian, Vonhören, David, Zaman, Julia, Valinciute, Gintvile, Herter, Sonja, Picard, Daniel, Rettenmeier, Johanna, Maass, Kendra K., Pajtler, Kristian W., Remke, Marc, von Deimling, Andreas, Pusch, Stefan, Pfister, Stefan M., Oehme, Ina, Jones, David T.W., Halbach, Sebastian, Brummer, Tilman, Martinez-Barbera, Juan Pedro, Witt, Olaf, Milde, Till, and Sigaud, Romain

Published
2024
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3. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Author

Peterziel, Heike, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F., Herter, Sonja, Fiesel, Petra, Berker, Yannick, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C., Reuss, David, Turunen, Laura, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U., Gojo, Johannes, Hutter, Caroline, Øra, Ingrid, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert, Nathrath, Michaela, Sparber-Sauer, Monika, Sehested, Astrid, Kramm, Christof M., Dirksen, Uta, Kallioniemi, Olli, Pfister, Stefan M., van Tilburg, Cornelis M., Jones, David T. W., Saarela, Jani, Pietiäinen, Vilja, Jäger, Natalie, Schlesner, Matthias, Kopp-Schneider, Annette, Oppermann, Sina, Milde, Till, Witt, Olaf, and Oehme, Ina

Published
2022
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4. Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

Author

Neurochirurgie, Brain, Seiboldt, Till, Zeiser, Constantia, Nguyen, Duy, Celikyürekli, Simay, Herter, Sonja, Najafi, Sara, Stroh-Dege, Alexandra, Meulenbroeks, Chris, Mack, Norman, Salem-Altintas, Rabia, Westermann, Frank, Schlesner, Matthias, Milde, Till, Kool, Marcel, Holland-Letz, Tim, Vogler, Meike, Peterziel, Heike, Witt, Olaf, Oehme, Ina, Neurochirurgie, Brain, Seiboldt, Till, Zeiser, Constantia, Nguyen, Duy, Celikyürekli, Simay, Herter, Sonja, Najafi, Sara, Stroh-Dege, Alexandra, Meulenbroeks, Chris, Mack, Norman, Salem-Altintas, Rabia, Westermann, Frank, Schlesner, Matthias, Milde, Till, Kool, Marcel, Holland-Letz, Tim, Vogler, Meike, Peterziel, Heike, Witt, Olaf, and Oehme, Ina

Published
2024

6. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Author

Peterziel, Heike; https://orcid.org/0000-0001-9261-7144, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F, Herter, Sonja, Fiesel, Petra, Berker, Yannick; https://orcid.org/0000-0002-6707-0834, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C, Reuss, David, Turunen, Laura; https://orcid.org/0000-0003-0274-4794, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin; https://orcid.org/0000-0001-7616-7665, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U; https://orcid.org/0000-0002-1783-631X, Gojo, Johannes, Hutter, Caroline; https://orcid.org/0000-0003-2059-4814, Øra, Ingrid; https://orcid.org/0000-0002-3931-4125, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert; https://orcid.org/0000-0002-2248-323X, Nathrath, Michaela, Sparber-Sauer, Monika; https://orcid.org/0000-0001-9551-2399, et al, Peterziel, Heike; https://orcid.org/0000-0001-9261-7144, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F, Herter, Sonja, Fiesel, Petra, Berker, Yannick; https://orcid.org/0000-0002-6707-0834, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C, Reuss, David, Turunen, Laura; https://orcid.org/0000-0003-0274-4794, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin; https://orcid.org/0000-0001-7616-7665, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U; https://orcid.org/0000-0002-1783-631X, Gojo, Johannes, Hutter, Caroline; https://orcid.org/0000-0003-2059-4814, Øra, Ingrid; https://orcid.org/0000-0002-3931-4125, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert; https://orcid.org/0000-0002-2248-323X, Nathrath, Michaela, Sparber-Sauer, Monika; https://orcid.org/0000-0001-9551-2399, and et al

Abstract

The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75-78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67%), sufficient viable tissue was received; 69 (78%) passed internal quality controls. The DSP results matched the identified molecular targets, including BRAF, ALK, MET, and TP53 status. Drug vulnerabilities were identified in 80% of cases lacking actionable (very) high-evidence molecular events, adding value to the molecular data. Striking parallels between clinical courses and the DSP results were observed in selected patients. Overall, DSP in clinical real-time is feasible in international multicenter precision oncology programs.

Published
2022

7. Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models

Author

Gatzweiler, Charlotte, primary, Ridinger, Johannes, additional, Herter, Sonja, additional, Gerloff, Xenia F., additional, ElHarouni, Dina, additional, Berker, Yannick, additional, Imle, Roland, additional, Schmitt, Lukas, additional, Kreth, Sina, additional, Stainczyk, Sabine, additional, Ayhan, Simay, additional, Najafi, Sara, additional, Krunic, Damir, additional, Frese, Karen, additional, Meder, Benjamin, additional, Reuss, David, additional, Fiesel, Petra, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Jones, David T. W., additional, Banito, Ana, additional, Westermann, Frank, additional, Oppermann, Sina, additional, Milde, Till, additional, Peterziel, Heike, additional, Witt, Olaf, additional, and Oehme, Ina, additional

Published
2022
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8. ERBB and P‐glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P‐glycoprotein.

Author

Rösch, Lisa, Herter, Sonja, Najafi, Sara, Ridinger, Johannes, Peterziel, Heike, Cinatl, Jindrich, Jones, David T. W., Michaelis, Martin, Witt, Olaf, and Oehme, Ina

Abstract

Chemotherapy resistance is a persistent clinical problem in relapsed high‐risk neuroblastomas. We tested a panel of 15 drugs for sensitization of neuroblastoma cells to the conventional chemotherapeutic vincristine, identifying tariquidar, an inhibitor of the transmembrane pump P‐glycoprotein (P‐gp/ABCB1), and the ERBB family inhibitor afatinib as the top resistance breakers. Both compounds were efficient in sensitizing neuroblastoma cells to vincristine in trypan blue exclusion assays and in inducing apoptotic cell death. The evaluation of ERBB signaling revealed no functional inhibition, that is, dephosphorylation of the downstream pathways upon afatinib treatment but direct off‐target interference with P‐gp function. Depletion of ABCB1, but not ERRB4, sensitized cells to vincristine treatment. P‐gp inhibition substantially broke vincristine resistance in vitro and in vivo (zebrafish embryo xenograft). The analysis of gene expression datasets of more than 50 different neuroblastoma cell lines (primary and relapsed) and more than 160 neuroblastoma patient samples from the pediatric precision medicine platform INFORM (Individualized Therapy For Relapsed Malignancies in Childhood) confirmed a pivotal role of P‐gp specifically in neuroblastoma resistance at relapse, while the ERBB family appears to play a minor part. [ABSTRACT FROM AUTHOR]

Published
2023
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