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1,239 results on '"Hertl, M."'

1. Das deutsche Psoriasis-Register PsoBest: Aktueller Stand, Patientencharakteristika und Auswirkungen auf die Gesundheitsversorgung

Author

Kühl, L, Sorbe, C, Rustenbach, SJ, Schaeffer, L, Ehlers, J, Alekseeva, A, Linder, L, Ben-Anaya, N, Boehncke, WH, Mrowietz, U, Staubach-Renz, P, von Kiedrowski, R, Thaci, D, Hertl, M, Augustin, M, Kühl, L, Sorbe, C, Rustenbach, SJ, Schaeffer, L, Ehlers, J, Alekseeva, A, Linder, L, Ben-Anaya, N, Boehncke, WH, Mrowietz, U, Staubach-Renz, P, von Kiedrowski, R, Thaci, D, Hertl, M, and Augustin, M

Published
2024

12. PsoBest: Aktueller Stand, Patientenprofile und Auswirkungen auf die Gesundheitsversorgung durch das deutsche Psoriasisregister

Author

Kühl, L, Sorbe, C, Rustenbach, SJ, Schaeffer, L, Schade, U, Ehlers, J, Ben-Anaya, N, Boehnke, WH, Mrowietz, U, Staubach-Renz, P, Strömer, K, von Kiedrowski, R, Thaci, D, Hertl, M, Augustin, M, Kühl, L, Sorbe, C, Rustenbach, SJ, Schaeffer, L, Schade, U, Ehlers, J, Ben-Anaya, N, Boehnke, WH, Mrowietz, U, Staubach-Renz, P, Strömer, K, von Kiedrowski, R, Thaci, D, Hertl, M, and Augustin, M

Published
2023

15. Einsatz B-Zell-depletierender Antikörper bei Hauterkrankungen

Author

Nagel, A., Hertl, M., and Eming, R.

Abstract

Zusammenfassung: Grundlegende Erkenntnisse über die immunologischen Mechanismen, besonders über die Bedeutung verschiedener Immunzellen und proinflammatorischer Zytokine, in der Ätiopathogenese von entzündlichen Dermatosen und Autoimmunerkrankungen der Haut führten in den letzten Jahren zur Entwicklung zahlreicher neuer Behandlungsstrategien. B-Lymphozyten besitzen aufgrund ihrer Eigenschaften als Antigen präsentierende Zellen und Vorläufer Autoantikörper sezernierender Plasmazellen eine außerordentliche Bedeutung im Autoimmunprozess. Sie stellen daher einen wichtigen Angriffspunkt in der Therapie dieser Erkrankungen dar. Die durch B-Zell-Depletion mit dem monoklonalen anti-CD20-Antikörper Rituximab beobachtete klinische Besserung bei Patienten mit rheumatoider Arthritis forcierte das Interesse am Einsatz B-Zell-gerichteter Therapien bei verschiedenen Autoimmunerkrankungen. Die Bedeutung einer beeinträchtigten B-Zell-Funktion bei der Entstehung und Progression von dermatologischen Autoimmunerkrankungen ist bisher nicht vollständig geklärt und aktuell Gegenstand zahlreicher klinischer und immunologischer Untersuchungen.

Published
2024
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21. Lichen planus pemphigoides after COVID‐19 infection.

Author

Didona, D., Sequeira‐Santos, Antonio M., Hinterseher, J., Cunha, T., and Hertl, M.

Subjects
BULLOUS pemphigoid, LICHEN planus, COVID-19, SYSTEMIC lupus erythematosus, SKIN proteins
Abstract

This article discusses a rare autoimmune bullous disease called lichen planus pemphigoides (LPP) that developed in a 50-year-old Caucasian male two weeks after a COVID-19 infection. LPP is characterized by lichenoid and/or bullous skin lesions and the presence of IgG autoantibodies against certain proteins in the skin and mucous membranes. The patient in this case study exhibited the clinical, histopathological, and serological criteria for LPP. The article also mentions the overlap between LPP, bullous lichen planus, and bullous pemphigoid, and highlights the importance of detecting autoantibodies to support the diagnosis. This is the first reported case of LPP after a COVID-19 infection. [Extracted from the article]

Published
2024
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27. Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV)

Author

Borradori, L., primary, Van Beek, N., additional, Feliciani, C., additional, Tedbirt, B., additional, Antiga, E., additional, Bergman, R., additional, Böckle, B. C., additional, Caproni, M., additional, Caux, F., additional, Chandran, N.S., additional, Cianchini, G., additional, Daneshpazhooh, M., additional, De, D., additional, Didona, D., additional, Di Zenzo, G. M., additional, Dmochowski, M., additional, Drenovska, K., additional, Ehrchen, J., additional, Goebeler, M., additional, Groves, R., additional, Günther, C., additional, Horvath, B., additional, Hertl, M., additional, Hofmann, S., additional, Ioannides, D., additional, Itzlinger‐Monshi, B., additional, Jedličková, J., additional, Kowalewski, C., additional, Kridin, K., additional, Lim, Y. L., additional, Marinovic, B., additional, Marzano, A. V., additional, Mascaro, J.‐M., additional, Meijer, J.M., additional, Murrell, D., additional, Patsatsi, K., additional, Pincelli, C., additional, Prost, C., additional, Rappersberger, K., additional, Sárdy, M., additional, Setterfield, J., additional, Shahid, M., additional, Sprecher, E., additional, Tasanen, K., additional, Uzun, S., additional, Vassileva, S., additional, Vestergaard, K., additional, Vorobyev, A., additional, Vujic, I., additional, Wang, G., additional, Wozniak, K., additional, Yayli, S., additional, Zambruno, G., additional, Zillikens, D., additional, Schmidt, E., additional, and Joly, P., additional

Published
2022
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30. PsoBest: Aktueller Stand, Patientenprofile und Auswirkungen auf die Gesundheitsversorgung durch das deutsche Psoriasisregister

Author

Schaeffer, L, Sorbe, C, Rustenbach, SJ, Kühl, L, Schade, U, Ehlers, J, Kirsten, N, Ben-Anaya, N, Boehncke, WH, Hertl, M, von Kiedrowski, R, Mrowietz, U, Staubach-Renz, P, Strömer, K, Thaci, D, Augustin, M, Schaeffer, L, Sorbe, C, Rustenbach, SJ, Kühl, L, Schade, U, Ehlers, J, Kirsten, N, Ben-Anaya, N, Boehncke, WH, Hertl, M, von Kiedrowski, R, Mrowietz, U, Staubach-Renz, P, Strömer, K, Thaci, D, and Augustin, M

Published
2022

31. Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV)

Author

Yaylı, Savaş (ORCID 0000-0001-9402-940X & YÖK ID 151352), Borradori, L.; Van Beek, N.; Feliciani, C.; Tedbirt, B.; Antiga, E.; Bergman, R.; Boeckle, B. C.; Caproni, M.; Caux, F.; Chandran, N. S.; Cianchini, G.; Daneshpazhooh, M.; De, D.; Didona, D.; Di Zenzo, G. M.; Dmochowski, M.; Drenovska, K.; Ehrchen, J.; Goebeler, M.; Groves, R.; Guenther, C.; Horvath, B.; Hertl, M.; Hofmann, S.; Ioannides, D.; Itzlinger-Monshi, B.; Jedlickova, J.; Kowalewski, C.; Kridin, K.; Lim, Y. L.; Marinovic, B.; Marzano, A.; Mascaro, J. -M.; Meijer, J. M.; Murrell, D.; Patsatsi, K.; Pincelli, C.; Prost, C.; Rappersberger, K.; Sardy, M.; Setterfield, J.; Shahid, M.; Sprecher, E.; Tasanen, K.; Uzun, S.; Vassileva, S.; Vestergaard, K.; Vorobyev, A.; Vujic, I.; Wang, G.; Wozniak, K.; Zambruno, G.; Zillikens, D.; Schmidt, E.; Joly, P., School of Medicine, Yaylı, Savaş (ORCID 0000-0001-9402-940X & YÖK ID 151352), Borradori, L.; Van Beek, N.; Feliciani, C.; Tedbirt, B.; Antiga, E.; Bergman, R.; Boeckle, B. C.; Caproni, M.; Caux, F.; Chandran, N. S.; Cianchini, G.; Daneshpazhooh, M.; De, D.; Didona, D.; Di Zenzo, G. M.; Dmochowski, M.; Drenovska, K.; Ehrchen, J.; Goebeler, M.; Groves, R.; Guenther, C.; Horvath, B.; Hertl, M.; Hofmann, S.; Ioannides, D.; Itzlinger-Monshi, B.; Jedlickova, J.; Kowalewski, C.; Kridin, K.; Lim, Y. L.; Marinovic, B.; Marzano, A.; Mascaro, J. -M.; Meijer, J. M.; Murrell, D.; Patsatsi, K.; Pincelli, C.; Prost, C.; Rappersberger, K.; Sardy, M.; Setterfield, J.; Shahid, M.; Sprecher, E.; Tasanen, K.; Uzun, S.; Vassileva, S.; Vestergaard, K.; Vorobyev, A.; Vujic, I.; Wang, G.; Wozniak, K.; Zambruno, G.; Zillikens, D.; Schmidt, E.; Joly, P., and School of Medicine

Abstract

Background: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, generalized bullous lesions. A subset of patients only develops excoriations, prurigo-like lesions, and eczematous and/or urticarial erythematous lesions. The disease, which is significantly associated with neurological disorders, has high morbidity and severely impacts the quality of life. Objectives and methodology: the Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology sought to update the guidelines for the management of BP based on new clinical information, and new evidence on diagnostic tools and interventions. The recommendations are either evidence-based or rely on expert opinion. The degree of consent among all task force members was included. Results: treatment depends on the severity of BP and patients' comorbidities. High-potency topical corticosteroids are recommended as the mainstay of treatment whenever possible. Oral prednisone at a dose of 0.5 mg/kg/day is a recommended alternative. In case of contraindications or resistance to corticosteroids, immunosuppressive therapies, such as methotrexate, azathioprine, mycophenolate mofetil or mycophenolate acid, may be recommended. The use of doxycycline and dapsone is controversial. They may be recommended, in particular, in patients with contraindications to oral corticosteroids. B-cell-depleting therapy and intravenous immunoglobulins may be considered in treatment-resistant cases. Omalizumab and dupilumab have recently shown promising results. The final version of the guideline was consented to by several patient organizations. Conclusions: the guidelines for the management of BP were updated. They summarize evidence- and expert-based recommendations useful in clinical practice., The guideline update was partly supported by the European Academy of Dermatology and Venereology (EADV) and the European Network for Rare Skin Disorders (ERN).

Published
2022

43. Comprehensive Allergy Center AZH am Universitätsklinikum Marburg

Author

Pfützner, W., primary, Pickert, J., additional, Mühlenbein, S., additional, Möbs, C., additional, Hertl, M., additional, Nastev, A., additional, Hoch, S., additional, Stuck, B.A., additional, Bauck, M., additional, Weber, S., additional, Skevaki, C., additional, Renz, H., additional, and Pfaar, O., additional

Published
2021
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49. Association with HLA-DRB1 in Egyptian and German pemphigus vulgaris patients

Author

Haase, O., Alneebari, R., Eldarouti, M. A., El Hady, Abd M., Dorgham, D., El-Nabarawy, E., El Din Mahmoud, S. B., El Sayed, Mosaad H., Darwish, M., Abbas, F., Salah, S., Mosaad, Y., El-Chennawi, F., Al Mongy, S., Abdelaziz, A. M., El Gaber, Abd S., Hertl, M., Eming, R., Recke, A., Möller, S., Schmidt, E., Zillikens, D., and Ibrahim, S.

Published
2015
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