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Hintergrund und Stand (inter)nationaler Forschung: Sportliche Aktivität hat einen positiven Einfluss auf die Symptomatik von Menschen mit psychischen Erkrankungen [ref:1]. Die Bewegungsintervention ImPuls soll sie darin unterstützen, ihre Symptomatik zu verbessern und sportliche [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Individuals who develop a mental disorder often present with not only one diagnosis, but high rates of comorbidities over the course of their lives. Therefore, research has developed an interest in identifying transdiagnostic processes that can help explain dysfunction across disorders. At the same time, this offers the possibility to target different clinical pictures with a more general intervention and thus to potentially improve the efficacy of treatments. One process that has received much attention as a possible transdiagnostic factor is emotion regulation (ER). There is evidence that deficits in ER are associated with increased levels of symptoms across a number of psychological disorders, including depression and anxiety (Brockmeyer et al., 2012; Joormann & Stanton, 2016; Mennin et al., 2009). However, studies investigating deficits in ER as a transdiagnostic process have provided mixed results: On the one hand, some results indeed support the transdiagnostic nature of ER; on the other hand, there is empirical evidence that particular ER difficulties are rather disorder-specific (Aldao et al., 2016; Im & Kahler, 2022; Lukas et al., 2018). Shukla and Pandey (2021) proposed a combination by suggesting, that only some ER difficulties may be transdiagnostic while other ER difficulties may be unique to specific disorders. They empirically tested their assumption by examining different components of ER deficits, based on the framework proposed by (Gratz & Roemer, 2004). Gratz and Roemer (2004) suggested that ER deficits can occur in the following domains: awareness and understanding of emotions, acceptance of emotional experiences, the ability to engage in goal-directed behaviors and control impulsive behaviors while facing negative emotions, and the use of strategies to modulate emotions in accordance with the situational demands. Shukla and Pandey (2021) included a subclinical sample with symptoms of either anxiety or both anxiety and depression in their study. They found that both subclinical groups showed a higher total score of ER deficits than the healthy sample, with the mixed group showing the highest level of deficits. When zooming in to the specific domains of ER difficulties, certain ER difficulties, namely non-acceptance of emotional response, impulse control difficulties, and limited access to ER strategies were only found in the anxious-depressed group, while difficulties engaging in goal-directed behavior, lack of emotional awareness and emotional clarity were found in both subclinical groups (Shukla & Pandey, 2021). In this study we aim to investigate which ER deficits can be found in individuals with a depression or an anxiety disorder. Thereby, we follow and extend the analogue study of Shukla and Pandey (2021) by recruiting a clinical sample with diagnosed disorders of a) depression, b) an anxiety disorder and c) depression and anxiety disorder. Note, the individuals may have additional comorbid diagnoses (e.g., nonorganic insomnia, obsessive-compulsive disorder, etc. for inclusion in this study. In this way, we hope to provide further evidence to clarify which deficits in ER are present in both depression and anxiety-related disorders, or if stronger degrees of difficulties are merely due to comorbidity between these two disorders. In order to further examine this possible dose-response relationship in more detail, we will also examine the extent of ER deficits depending on the number of disorders or comorbidities regardless of the type of disorder. Research has generally suggested that deficits in ER are linked to specific ER strategies, like repetitive negative thinking (RNT) that impede ER. For RNT, as for ER deficits, a transdiagnostic relationship is often assumed. Furthermore, it has also been shown for RNT that it increases as the number of comorbid diagnoses increases (McEvoy et al., 2013). Therefore, we will additionally investigate this particular ER strategy with respect to its occurrence in the different diagnostic groups as well as depending on the numbers of comorbid disorders.

This research question is a part of the ImPuls study. The study protocol of the ImPuls study is published at https://doi.org/10.1186/s12888-021-03541-3 and registered in the German Clinical Trial Register (ID: DRKS00024152, 05/02/2021).

Although there are many studies that clearly show a relationship between mental health and trait emotional intelligence (TEI), there have been only few studies that have examined clinical samples (Andrei et al., 2014; Hansen et al., 2009). Furthermore, it is particularly noticeable that most studies only looked at global TEI scores. But since TEI has many facets, it may also be important to look at the subdimensions of TEI and especially whether disorders differ in terms of the association with these dimensions. The aim of this study is, therefore, to investigate whether individuals with different mental disorders, differ significantly from healthy control groups on different TEI facets, measured with the TEIQue. For this purpose, a large patient sample, with different diagnoses (including depression, anxiety-related disorder, or insomnia) was recruited. Matched healthy control groups will be recruited. We expect that participants with a depression, participants with an anxiety-related disorder, and participants with insomnia will score lower on the global TEI score as well as on all subscales of the TEIQue compared to the healthy controls.

Additional file 1. TIDieR-Checklist.pdf (TIDieR Checklist).

Background: The expected genetic variance is an important criterion for the selection of crossing partners which will produce superior combinations of genotypes in their progeny. The advent of molecular markers has opened up new vistas for obtaining precise predictors for the genetic variance of a cross, but fast prediction methods that allow plant breeders to select crossing partners based on already available data from their breeding programs without complicated calculations or simulation of breeding populations are still lacking. The main objective of the present study was to demonstrate the practical applicability of an analytical approach for the selection of superior cross combinations with experimental data from a barley breeding program. We used genome-wide marker effects to predict the yield means and genetic variances of 14 DH families resulting from crosses of four donor lines with five registered elite varieties with the genotypic information of the parental lines. For the validation of the predicted parameters, the analytical approach was extended by the masking variance as a major component of phenotypic variance. The predicted parameters were used to fit normal distribution curves of the phenotypic values and to conduct an Anderson-Darling goodness-of-fit test for the observed phenotypic data of the 14 DH families from the field trial. Results: There was no evidence that the observed phenotypic values deviated from the predicted phenotypic normal distributions in 13 out of 14 crosses. The correlations between the observed and the predicted means and the observed and predicted variances were r = 0.95 and r = 0.34, respectively. After removing two crosses with downward outliers in the phenotypic data, the correlation between the observed and predicted variances increased to r = 0.76. A ranking of the 14 crosses based on the sum of predicted mean and genetic variance identified the 50% best crosses from the field trial correctly. Conclusions: We conclude that the prediction accuracy of the presented approach is sufficiently high to identify superior crosses even with limited phenotypic data. We therefore expect that the analytical approach based on genome-wide marker effects is applicable in a wide range of breeding programs.

Ziel dieser Studie ist der Vergleich der Wirksamkeit von intravitrealem Triamcinolon und Bevacizumab in der Behandlung von Makulaödemen bei Patienten mit retinalen Venenverschlüssen. Die vorliegende retrospektive Studie veranschaulicht die kurzfristige Wirksamkeit beider Medikamente auf die zentrale Netzhautdicke. Die gemessene Reduktion der zentralen Netzhautdicke korreliert jedoch nicht mit einem signifikanten Visusgewinn. The purpose of this study is to compare the efficacy of intravitreal triamcinolone versus bevacizumab in the treatment of macular edema caused by retinal vein occlusion. The present retrospective study demonstrates the short-term efficacy of both treatments concerning central macular thickness. However, this reduction of macular edema does not correlate with a significant gain of visual acuity.