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22 results on '"Hess, Mary M."'

13. Superiority of aztreonam/clindamycin compared with gentamicin/clindamycin in patients with penetrating abdominal trauma

Author

Fabian, Timothy C., Hess, Mary M., Croce, Martin A., Wilson, Robert S., Wilson, Samuel E., Charland, Scott L., Rodman, John H., and Boucher, Bradley A.

Subjects
Drug therapy, Combination -- Evaluation, Gentamicin -- Evaluation, Clindamycin -- Evaluation, Aztreonam -- Evaluation, Abdomen -- Injuries, Penetrating wounds -- Drug therapy, Health
Abstract

There were 73 evaluable patients entered into a prospective, double-blinded trial comparing aztreonam/clindamycin (A/C) to gentamicin/clindamycin (G/C) for the prevention of infection after penetrating abdominal trauma. Aztreonam was administered at a dosage of 2 g every 8 hours and gentamicin at 5 mg/kg for the first 24 hours and then adjusted by serum monitoring to a peak of 6 to 8 [mu]g/mL and a trough of less than 2 [mu]g/mL; all patients received 900 mg of clindamycin every 8 hours. Patients with colon wounds received 4 days of antibiotics, and the remaining patients received a 24-hour course. Gunshot wounds occurred in 69% of patients: 74% of all patients had some hollow viscus injury, and 26% had only solid viscus injury. The groups were well matched according to abdominal trauma index, percentage with colon injury, and transfusion requirements. Failures occurred in eight patients (11%): two wound infections, five intra-abdominal infections, and one case of necrotizing fasciitis. Seven infections occurred in 36 (19%) G/C patients compared with 1 in 37 (3%) A/ C patients (p < 0.03). The hospital stay was 12 [+ or -] 11 days for G/C patients and 8 [+ or -] 7 for A/ C patients (p < 0.12). The superiority of the A/C regimen may be partially attributable to relative underdosing of gentamicin (approximately half of the patients had inadequate levels after 24 hours) combined with a favorable pharmacokinetic profile (significantly prolonged half-life) of aztreonam in this clinical setting.

Published
1994

17. Fluconazole Pharmacokinetics in Burn Patients

Author

Boucher, Bradley A., primary, King, Stephen R., additional, Wandschneider, Heidi L., additional, Hickerson, William L., additional, Hanes, Scott D., additional, Herring, Vanessa L., additional, Canada, Todd W., additional, and Hess, Mary M., additional

Published
1998
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22. ACCP WHITE PAPER.

Author

Goodwin, S. Diane, Kane-Gill, Sandra L., Ng, Tien M. H., Melroy, Joel T., Hess, Mary M., Tallian, Kimberly, Trujillo, Toby C., and Vermeulen, Lee C.

Subjects
COLLEGE publications, INCENTIVE awards, CAREER development, PHARMACISTS, WORK-life balance
Abstract

The article focuses on the updated white paper "Rewards and Advancements for Clinical Pharmacy Practitioners," published by the American College of Clinical Pharmacy (ACCP). The white paper discusses existing systems of providing rewards and allowing career advancements for clinical pharmacists. According to clinical pharmacists surveyed, the significant factors for success in their career include work-life balance and professional advancement opportunities. Two thirds of the clinical pharmacists were found to have no professional development plan.

Published
2010

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