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860 results on '"Hesselink, Matthijs"'

1. Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2

Author

Chen, Sha, Wang, Qian, Bakker, Diane, Hu, Xin, Zhang, Liping, van der Made, Ingeborg, Tebbens, Anna M., Kovácsházi, Csenger, Giricz, Zoltán, Brenner, Gábor B., Ferdinandy, Peter, Schaart, Gert, Gemmink, Anne, Hesselink, Matthijs K. C., Rivaud, Mathilde R., Pieper, Michael P., Hollmann, Markus W., Weber, Nina C., Balligand, Jean-Luc, Creemers, Esther E., Coronel, Ruben, and Zuurbier, Coert J.

Published
2024
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3. Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial

Author

van Beek, Sten M. M., Bruls, Yvonne M. H., Vanweert, Froukje, Fealy, Ciarán E., Connell, Niels J., Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna A., Vaz, Frédéric M., Smeets, Ellen T. H. C., Joris, Peter J., Gemmink, Anne, Houtkooper, Riekelt H., Hesselink, Matthijs K. C., Bengtsson, Tore, Havekes, Bas, Schrauwen, Patrick, and Hoeks, Joris

Published
2023
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6. Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Author

Erickson, Melissa L., Allen, Jacob M., Beavers, Daniel P., Collins, Linda M., Davidson, Karina W., Erickson, Kirk I., Esser, Karyn A., Hesselink, Matthijs K. C., Moreau, Kerrie L., Laber, Eric B., Peterson, Charlotte A., Peterson, Courtney M., Reusch, Jane E., Thyfault, John P., Youngstedt, Shawn D., Zierath, Juleen R., Goodpaster, Bret H., LeBrasseur, Nathan K., Buford, Thomas W., and Sparks, Lauren M.

Published
2023
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9. Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism

Author

op den Kamp, Yvo J.M., Gemmink, Anne, de Ligt, Marlies, Dautzenberg, Bas, Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Esterline, Russell, Pava, Diego A., Hoeks, Joris, Schrauwen-Hinderling, Vera B., Kersten, Sander, Havekes, Bas, Koves, Timothy R., Muoio, Deborah M., Hesselink, Matthijs K.C., Oscarsson, Jan, Phielix, Esther, and Schrauwen, Patrick

Published
2022
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11. Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T.

Author

Mevenkamp, Julian, Bruls, Yvonne M. H., Mancilla, Rodrigo, Grevendonk, Lotte, Wildberger, Joachim E., Brouwers, Kim, Hesselink, Matthijs K. C., Schrauwen, Patrick, Hoeks, Joris, Houtkooper, Riekelt H., Buitinga, Mijke, de Graaf, Robin A., Lindeboom, Lucas, and Schrauwen-Hinderling, Vera B.

Subjects
NUCLEAR magnetic resonance spectroscopy, ELECTROPHILES, OLDER people, SKELETAL muscle, RESEARCH personnel, NAD (Coenzyme)
Abstract

NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31P-MRS) method to quantify these metabolites in human skeletal muscle on a clinical 3 T MRI scanner. This new MR-sequence enables NADH and NAD+ quantification by suppressing α-ATP signal, normally overlapping with NADH and NAD+. The sequence is based on a double spin echo in combination with a modified z-Filter achieving strong α-ATP suppression with little effect on NAD+ and NADH. Here we test and validate it in phantoms and in humans by measuring reproducibility and detecting a physiological decrease in NAD+ and increase in NADH induced by ischemia. Furthermore, the 31P-MRS outcomes are compared to analysis in biopsies. Additionally, we show higher NAD+ and lower NADH content in physically active older adults compared to sedentary individuals, reflecting increased metabolic health. NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. Here, the researchers developed and validated a non-invasive Phosphorous Magnetic Resonance Spectroscopy method to non-invasively quantify NAD+ and NADH in muscle on a clinical 3 T MRI scanner. [ABSTRACT FROM AUTHOR]

Published
2024
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12. De effecten van een PPAR-α-agonist (ciprofibraat) op de weefselspecifieke glucoseopname in insulineresistentie; resultaten van een gerandomiseerde dubbelblinde placebogecontroleerde cross-overstudie.

Author

de Wit-Verheggen, Vera, Vanweert, Froukje, Raiko, Juho, Liénard, Viktor, Schaart, Gert, Gemmink, Anne, Nascimento, Emmani, Hesselink, Matthijs, Wildberger, Joachim, Wierts, Roel, Joris, Peter, Haas, Joel, Montaigne, David, Staels, Bart, Phielix, Esther, Schrauwen, Patrick, Schrauwen-Hinderling, Vera, and van de Weijer, Tineke

Published
2024
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21. Metabolic responses to mild cold acclimation in type 2 diabetes patients

Author

Remie, Carlijn M. E., Moonen, Michiel P. B., Roumans, Kay H. M., Nascimento, Emmani B. M., Gemmink, Anne, Havekes, Bas, Schaart, Gert, Kornips, Esther, Joris, Peter J., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Kersten, Sander, Hesselink, Matthijs K. C., Phielix, Esther, Lichtenbelt, Wouter D. van Marken, and Schrauwen, Patrick

Published
2021
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23. One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Author

Bilet, Lena, Phielix, Esther, van de Weijer, Tineke, Gemmink, Anne, Bosma, Madeleen, Moonen-Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Zhang, Dongyan, Meijer, Kenneth, Hopman, Maria, Hesselink, Matthijs K. C., Ouwens, D. Margriet, Shulman, Gerald I., Schrauwen-Hinderling, Vera B., and Schrauwen, Patrick

Published
2020
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25. The tissue‐specific metabolic effects of the PPARα agonist ciprofibrate in insulin‐resistant male individuals: a double‐blind, randomized, placebo‐controlled crossover study

Author

de Wit‐Verheggen, Vera H. W., primary, Vanweert, Froukje, additional, Raiko, Juho, additional, Liénard, Viktor, additional, Schaart, Gert, additional, Gemmink, Anne, additional, Nascimento, Emmani B. M., additional, Hesselink, Matthijs K. C., additional, Wildberger, Joachim E., additional, Wierts, Roel, additional, Joris, Peter J., additional, Haas, Joel, additional, Montaigne, David, additional, Staels, Bart, additional, Phielix, Esther, additional, Schrauwen, Patrick, additional, Schrauwen‐Hinderling, Vera B., additional, and van de Weijer, Tineke, additional

Published
2023
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27. Differences in Performance Assessments Conducted Indoors and Outdoors in Professional Cyclists.

Author

Lipski, Elliot S., Spindler, David J., Hesselink, Matthijs K.C., Myers, Tony D., and Sanders, Dajo

Subjects
NATIONAL competency-based educational tests, CYCLING, ATHLETIC ability
Abstract

Purpose: The purpose of this study was to assess the relationship between typical performance tests among elite and professional cyclists when conducted indoors and outdoors. Methods: Fourteen male cyclists of either UCI (Union Cycliste Internationale) Continental or UCI World Tour level (mean [SD] age 20.9 [2.8] y, mass 68.13 [7.25] kg) were recruited to participate in 4 test sessions (2 indoors and 2 outdoors) within a 14-day period, consisting of maximum mean power testing for durations of 60, 180, 300, and 840 seconds. Results: Across all maximum mean power test durations, the trimmed mean power was higher outdoors compared with indoor testing (P <.05). Critical power was higher outdoors compared with indoors (+19 W, P =.005), while no difference was observed for the work capacity above critical power. Self-selected cadence was 6 rpm higher indoors versus outdoors for test durations of 60 (P =.038) and 300 seconds (P =.002). Conclusions: These findings suggest that maximal power testing in indoor and outdoor settings cannot be used interchangeably. Furthermore, there was substantial individual variation in the difference between indoor and outdoor maximum mean powers across all time durations, further highlighting the difficulty of translating results from indoor testing to outdoor on an individual level in elite populations. [ABSTRACT FROM AUTHOR]

Published
2022
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32. The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

Author

Vanweert, Froukje, Boone, Sebastiaan C., Brouwers, Bram, Mook-Kanamori, Dennis O., de Mutsert, Renée, Rosendaal, Frits R., Lamb, Hildo J., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick, Hesselink, Matthijs K. C., and Phielix, Esther

Abstract

Aims: To evaluate whether the association between plasma branched-chain amino acids (BCAA) and intrahepatic lipid (IHL) was affected by physical activity level. Furthermore, to investigate if a conventional exercise training program, a subcategory of physical activity, could lower plasma BCAA along with alterations in IHL content in patients with type 2 diabetes (T2DM) and people with nonalcoholic fatty liver (NAFL). Methods: To investigate the effect of physical activity on the association between plasma BCAA and IHL content, linear regression analyses were performed in 1983 individuals from the Netherlands Epidemiology of Obesity (NEO) stratified by physical activity frequency. Furthermore, the effect of a 12-week supervised combined aerobic resistance-exercise program on plasma BCAA, insulin sensitivity (hyperinsulinemic–euglycemic clamp), and IHL (proton-magnetic resonance spectroscopy (1H-MRS)) was investigated in seven patients with T2DM, seven individuals with NAFL and seven BMI-matched control participants (CON). Results: We observed positive associations between plasma valine, isoleucine and leucine level, and IHL content (1.29 (95% CI: 1.21, 1.38), 1.52 (95% CI: 1.43, 1.61), and 1.54 (95% CI: 1.44, 1.64) times IHL, respectively, per standard deviation of plasma amino acid level). Similar associations were observed in less active versus more active individuals. Exercise training did not change plasma BCAA levels among groups, but reduced IHL content in NAFL (from 11.6 ± 3.0% pre-exercise to 8.1 ± 2.0% post exercise, p&lt; 0.05) and CON (from 2.4 ± 0.6% pre-exercise to 1.6 ± 1.4% post exercise, p&lt; 0.05), and improved peripheral insulin sensitivity in NAFL as well by ~23% (p&lt; 0.05). Conclusions: The association between plasma BCAA levels and IHL is not affected by physical activity level. Exercise training reduced IHL without affecting plasma BCAA levels in individuals with NAFL and CON. We conclude that exercise training-induced reduction in IHL content is not related to changes in plasma BCAA levels. Trial registration: Trial registry number: NCT01317576.

Published
2024
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38. Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Author

Erickson, Melissa L., primary, Allen, Jacob M., additional, Beavers, Daniel P., additional, Collins, Linda M., additional, Davidson, Karina W., additional, Erickson, Kirk I., additional, Esser, Karyn A., additional, Hesselink, Matthijs K. C., additional, Moreau, Kerrie L., additional, Laber, Eric B., additional, Peterson, Charlotte A., additional, Peterson, Courtney M., additional, Reusch, Jane E., additional, Thyfault, John P., additional, Youngstedt, Shawn D., additional, Zierath, Juleen R., additional, Goodpaster, Bret H., additional, LeBrasseur, Nathan K., additional, Buford, Thomas W., additional, and Sparks, Lauren M., additional

Published
2022
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40. Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

Author

Catoire, Milène, Alex, Sheril, Paraskevopulos, Nicolas, Mattijssen, Frits, Gogh, Inkie Evers-van, Schaart, Gert, Jeppesen, Jacob, Kneppers, Anita, Mensink, Marco, Voshol, Peter J., Olivecrona, Gunilla, Tan, Nguan Soon, Hesselink, Matthijs K. C., Berbée, Jimmy F., Rensen, Patrick C. N., Kalkhoven, Eric, Schrauwen, Patrick, and Kersten, Sander

Published
2014

41. Invasive and noninvasive markers of human skeletal muscle mitochondrial function.

Author

Mancilla, Rodrigo, Pava‐Mejia, Diego, van Polanen, Nynke, de Wit, Vera, Bergman, Maaike, Grevendonk, Lotte, Jorgensen, Johanna, Kornips, Esther, Hoeks, Joris, Hesselink, Matthijs K. C., and Schrauwen‐Hinderling, Vera B.

Subjects
AEROBIC capacity, SKELETAL muscle, MITOCHONDRIA, EPICATECHIN, MITOCHONDRIAL DNA, CITRATE synthase
Abstract

Mitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and noninvasive markers of skeletal muscle mitochondrial capacity reflect mitochondrial respiration in permeabilized muscle fibers. Nineteen young men (mean age: 24 ± 4 years) were recruited, and a muscle biopsy was collected to determine mitochondrial respiration from permeabilized muscle fibers and to quantify markers of mitochondrial capacity, content such as citrate synthase (CS) activity, mitochondrial DNA copy number, TOMM20, VDAC, and protein content for complex I–V of the oxidative phosphorylation (OXPHOS) system. Additionally, all participants underwent noninvasive assessments of mitochondrial capacity: PCr recovery postexercise (by 31P‐MRS), maximal aerobic capacity, and gross exercise efficiency by cycling exercise. From the invasive markers, Complex V protein content and CS activity showed the strongest concordance (Rc = 0.50 to 0.72) with ADP‐stimulated coupled mitochondrial respiration, fueled by various substrates. Complex V protein content showed the strongest concordance (Rc = 0.72) with maximally uncoupled mitochondrial respiration. From the noninvasive markers, gross exercise efficiency, VO2max, and PCr recovery exhibited concordance values between 0.50 and 0.77 with ADP‐stimulated coupled mitochondrial respiration. Gross exercise efficiency showed the strongest concordance with maximally uncoupled mitochondrial respiration (Rc = 0.67). From the invasive markers, Complex V protein content and CS activity are surrogates that best reflect skeletal muscle mitochondrial respiratory capacity. From the noninvasive markers, exercise efficiency and PCr recovery postexercise most closely reflect skeletal muscle mitochondrial respiratory capacity. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Physical Activity Energy Expenditure in Dutch Adolescents: Contribution of Active Transport to School, Physical Education, and Leisure Time Activities

Author

Slingerland, Menno, Borghouts, Lars B., and Hesselink, Matthijs K. C.

Abstract

Background: Detailed knowledge about physical activity energy expenditure (PAEE) can guide the development of school interventions aimed at reducing overweight in adolescents. However, relevant components of PAEE have never been objectively quantified in this population. This study investigated the contribution of active transport to and from school, physical education (PE), and leisure time activities to total PAEE during a regular school week in adolescents. Methods: Seventy-three adolescents (mean age: 15.7 years) wore an individually calibrated combined heart rate-acceleration monitor and kept an activity diary during a regular school week. Branched equation modeling was used to calculate PAEE of the specific activity categories, and their relative contribution to total PAEE was determined. Results: Active transport and PE contributed 30.0% and 17.4%, respectively, to school-related PAEE. Active transport to and from school contributed 15% to total PAEE. Youth with a high physical activity level (PAL) spent 4 hours less in sedentary behavior than subjects with a medium or low PAL (F = 77.415 (2.70), p less than 0.001) and had higher PAEE during leisure time sports (F = 9.135 (2.70), p less than 0.001) and work-related activities (F = 10.583 (2.70), p less than 0.001) than youth with medium or low PAL values. Conclusions: Active transport and PE contribute significantly to PAEE during school hours in adolescents. To achieve an increase in total PAEE in the least active group of adolescents, promising strategies might be to reduce inactive behavior, increase participation in leisure time sports, and possibly to replace inactive for active jobs. (Contains 3 tables and 2 figures.)

Published
2012
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48. Aerobic exercise training improves not only brachial artery flow-mediated vasodilatation but also carotid artery reactivity: A randomized controlled, cross-over trial in older men

Author

Kleinloog, Jordi P.D., Mensink, R.P., Roodt, Jos Op't., Thijssen, D.H.J., Hesselink, Matthijs K. C., Joris, Peter J., Kleinloog, Jordi P.D., Mensink, R.P., Roodt, Jos Op't., Thijssen, D.H.J., Hesselink, Matthijs K. C., and Joris, Peter J.

Abstract

Contains fulltext : 253617.pdf (Publisher’s version ) (Open Access)

Published
2022

49. Commentaries on Viewpoint: Using V̇o2max as a marker of training status in athletes - can we do better?

Author

Valenzuela, Pedro L, Mateo-March, Manuel, Muriel, Xabier, Zabala, Mikel, Lucia, Alejandro, Barranco-Gil, David, Millet, Grégoire P, Brocherie, Franck, Burtscher, Johannes, Burtscher, Martin, Ryan, Benjamin J, Gioscia-Ryan, Rachel A, Perrey, Stephane, Rodrigo-Carranza, Víctor, González-Mohíno, Fernando, González-Ravé, José María, Santos-Concejero, Jordan, Denadai, Benedito S, Greco, Camila C, Casado, Arturo, Foster, Carl, Mazzolari, Raffaele, Baldrighi, Giulia Nicole, Pastorio, Elisa, Malatesta, Davide, Patoz, Aurélien, Borrani, Fabio, Ives, Stephen J, DeBlauw, Justin A, Dantas de Lucas, Ricardo, Borszcz, Fernando Klitzke, Fernandes Nascimento, Eduardo Marcel, Antonacci Guglielmo, Luiz Guilherme, Turnes, Tiago, Jaspers, Richard T, van der Zwaard, Stephan, Lepers, Romuald, Louis, Julien, Meireles, Anderson, de Souza, Hiago L. R., de Oliveira, Géssyca T, dos Santos, Marcelo P, Arriel, Rhaí A, Marocolo, Moacir, Hunter, B, Meyler, S, Muniz-Pumares, D, Ferreira, Renato M, Sogard, Abigail S, Carter, Stephen J, Mickleborough, Timothy D, Saborosa, Guilherme Pereira, de Oliveira Freitas, Raphael Dinalli, Alves dos Santos, Paula Souza, de Souza Ferreira, João Pedro, de Assis Manoel, Francisco, da Silva, Sandro Fernandes, Triska, Christoph, Karsten, Bettina, Sanders, Dajo, Lipksi, Elliot S, Spindler, David J, Hesselink, Matthijs K. C., Zacca, Rodrigo, Goethel, Márcio Fagundes, Pyne, David Bruce, Wood, Brayden M, Allen, Peyton E, Gabelhausen, Jaden L, Keller, Alexandra M, Lige, Mast T, Oumsang, Alicia S, Smart, Greg L, Paris, Hunter L, Dewolf, Arthur H, Toffoli, Guillaume, Martinez-Gonzalez, Borja, Marcora, Samuele M, Terson de Paleville, Daniela, Fernandes, Ricardo J, Soares, Susana M, Abraldes, J. Arturo, Matta, Guilherme, Bossi, Arthur Henrique, McCarthy, D G, Bostad, W, Gibala, J, Vagula, Mary, Valenzuela, Pedro L, Mateo-March, Manuel, Muriel, Xabier, Zabala, Mikel, Lucia, Alejandro, Barranco-Gil, David, Millet, Grégoire P, Brocherie, Franck, Burtscher, Johannes, Burtscher, Martin, Ryan, Benjamin J, Gioscia-Ryan, Rachel A, Perrey, Stephane, Rodrigo-Carranza, Víctor, González-Mohíno, Fernando, González-Ravé, José María, Santos-Concejero, Jordan, Denadai, Benedito S, Greco, Camila C, Casado, Arturo, Foster, Carl, Mazzolari, Raffaele, Baldrighi, Giulia Nicole, Pastorio, Elisa, Malatesta, Davide, Patoz, Aurélien, Borrani, Fabio, Ives, Stephen J, DeBlauw, Justin A, Dantas de Lucas, Ricardo, Borszcz, Fernando Klitzke, Fernandes Nascimento, Eduardo Marcel, Antonacci Guglielmo, Luiz Guilherme, Turnes, Tiago, Jaspers, Richard T, van der Zwaard, Stephan, Lepers, Romuald, Louis, Julien, Meireles, Anderson, de Souza, Hiago L. R., de Oliveira, Géssyca T, dos Santos, Marcelo P, Arriel, Rhaí A, Marocolo, Moacir, Hunter, B, Meyler, S, Muniz-Pumares, D, Ferreira, Renato M, Sogard, Abigail S, Carter, Stephen J, Mickleborough, Timothy D, Saborosa, Guilherme Pereira, de Oliveira Freitas, Raphael Dinalli, Alves dos Santos, Paula Souza, de Souza Ferreira, João Pedro, de Assis Manoel, Francisco, da Silva, Sandro Fernandes, Triska, Christoph, Karsten, Bettina, Sanders, Dajo, Lipksi, Elliot S, Spindler, David J, Hesselink, Matthijs K. C., Zacca, Rodrigo, Goethel, Márcio Fagundes, Pyne, David Bruce, Wood, Brayden M, Allen, Peyton E, Gabelhausen, Jaden L, Keller, Alexandra M, Lige, Mast T, Oumsang, Alicia S, Smart, Greg L, Paris, Hunter L, Dewolf, Arthur H, Toffoli, Guillaume, Martinez-Gonzalez, Borja, Marcora, Samuele M, Terson de Paleville, Daniela, Fernandes, Ricardo J, Soares, Susana M, Abraldes, J. Arturo, Matta, Guilherme, Bossi, Arthur Henrique, McCarthy, D G, Bostad, W, Gibala, J, and Vagula, Mary

Published
2022
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