45 results on '"Heuven, H."'
Search Results
2. Application of AFLP® technology to radiation hybrid mapping
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Gorni, C., Williams, J. L., Heuven, H. C. M., Negrini, R., Valentini, A., van Eijk, M. J. T., Waddington, D., Zevenbergen, M., Marsan, P. Ajmone, and Peleman, J. D.
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- 2004
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3. Analysis of variation in the melanocortin-4 receptor gene (mc4r) in golden retriever dogs
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van den Berg, L., van den Berg, S. M., Martens, E. E. C. P., Hazewinkel, H. A. W., Dijkshoorn, N. A., Delemarre-van de Waal, H. A., Heutink, P., Leegwater, P. A. J., and Heuven, H. C. M.
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- 2010
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4. Genetic parameters for guiding ability in purpose bred dogs
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Wijga, S., Russenberger, J., van den Berg, S. M., Havlena, B., and Heuven, H. C. M.
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- 2009
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5. Mapping markers linked to porcine salmonellosis susceptibility
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Galina-Pantoja, L., Siggens, K., van Schriek, M. G. M., and Heuven, H. C. M.
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- 2009
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6. Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs
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Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Techakumphu, M, Hazewinkel, H A W, CSCA AVM, CSCA TR1, dCSCA RMSC-1, dCSCA AVR, CSCA AVM, CSCA TR1, dCSCA RMSC-1, and dCSCA AVR
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Male ,Veterinary medicine ,Candidate gene ,medicine.medical_specialty ,Genome-wide association study ,Canis lupus familiaris ,040301 veterinary sciences ,Patellar Dislocation ,Population ,Patellar luxation ,Animal Breeding and Genomics ,0403 veterinary science ,Heritability ,Dogs ,Internal medicine ,Prevalence ,Animals ,Medicine ,Pomeranian ,Genetic Predisposition to Disease ,Fokkerij en Genomica ,Dog Diseases ,education ,education.field_of_study ,General Veterinary ,business.industry ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,Thailand ,040201 dairy & animal science ,Pedigree ,Relative risk ,Cohort ,Female ,business ,SNP array - Abstract
The genetics of patellar luxation (PL) were investigated in Pomeranian dogs presented at the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University. A cohort of 339 Pomeranian dogs, part of a four-generation pedigree of 842 Pomeranians, was screened for PL from 2006 to 2013. PL was present in 77% of the screened dogs, with 84% having bilateral and 16% unilateral luxation. Medial PL was more common (95%) than lateral PL (2%) or bidirectional PL (3%). The risk of PL was similar in male and female dogs (female:male relative risk 1.11, 95% CI 0.98–1.25). The heritability of PL in the screened population was 0.44 ± 0.04 using a threshold model. A genome-wide association study of PL (48 cases and 48 controls) using a high-density SNP array indicated the possible involvement of 15 chromosomal regions, of which CFA05 and CFA32 remained associated in a larger study involving an additional 128 cases and 7 controls. Candidate genes in these regions may be involved in the pathogenesis of PL in Pomeranian dogs.
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- 2017
7. Heritabilities of copper-accumulating traits in Labrador retrievers
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Hoffmann, G., Heuven, H. C. M., Leegwater, P. A. J., Jones, P. G., van den Ingh, T. S. G. A. M., Bode, P., and Rothuizen, J.
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- 2008
8. Genetic diversity in European pigs utilizing amplified fragment length polymorphism markers
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SanCristobal, M., Chevalet, C., Peleman, J., Heuven, H., Brugmans, B., van Schriek, M., Joosten, R., Rattink, A. P., Harlizius, B., Groenen, M. A. M., Amigues, Y., Boscher, M.-Y., Russell, G., Law, A., Davoli, R., Russo, V., Dèsautés, C., Alderson, L., Fimland, E., Bagga, M., Delgado, J. V., Vega-Pla, J. L., Martinez, A. M., Ramos, M., Glodek, P., Meyer, J. N., Gandini, G., Matassino, D., Siggens, K., Laval, G., Archibald, A., Milan, D., Hammond, K., Cardellino, R., Haley, C., and Plastow, G.
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- 2006
9. Genetic Diversity Analysis Using Lowly Polymorphic Dominant Markers: The Example of AFLP in Pigs
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Foulley, J.-L., van Schriek, M. G. M., Alderson, L., Amigues, Y., Bagga, M., Boscher, M.-.Y, Brugmans, B., Cardellino, R., Davoli, R., Delgado, J. V., Fimland, E., Gandini, G. C., Glodek, P., Groenen, M. A. M., Hammond, K., Harlizius, B., Heuven, H., Joosten, R., Martinez, A. M., Matassino, D., Meyer, J.-N., Peleman, J., Ramos, A. M., Rattink, A. P., Russo, V., Siggens, K. W., Vega-Pla, J. L., and Ollivier, L.
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- 2006
10. Skeletal and hepatic changes induced by chronic vitamin A supplementation in cats
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Corbee, R J, Tryfonidou, M A, Grinwis, G C M, Schotanus, B, Molenaar, M R, Voorhout, G, Vaandrager, A B, Heuven, H C M, Hazewinkel, H A W, LS Algemene chirurgie, Sub Neuro/Tandheelkunde, Veterinair Pathologisch Diagnostisch Cnt, PB AVM, Dep Pathobiologie, Onderzoek, Sub Biochemie Algemeen, Diagnostische beeldvorming, Beheer, LS Veterinaire biochemie, and Advances in Veterinary Medicine
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Male ,Vitamin ,medicine.medical_specialty ,food.ingredient ,Hypervitaminosis ,Bone and Bones ,Random Allocation ,chemistry.chemical_compound ,food ,Hepatic stellate cells ,Fibrosis ,Internal medicine ,Hamd ,Vitamin D and neurology ,medicine ,Animals ,Vitamin D ,Vitamin A ,CATS ,Dose-Response Relationship, Drug ,General Veterinary ,business.industry ,Vitamins ,Hyperostosis ,medicine.disease ,Animal Feed ,Diet ,Endocrinology ,Liver ,chemistry ,Dietary Supplements ,Cats ,Hepatic stellate cell ,Peanut oil ,Female ,Animal Science and Zoology ,business - Abstract
The first aim of this study was to determine whether vitamin D supplementation influenced the effects of high vitamin A intake on new bone formation in adult cats. The second aim was to determine whether high vitamin A intake in cats caused liver pathology and, if so, whether the current upper limit for the dietary intake of vitamin A for healthy adult cats would be safe. Twenty-four healthy adult cats were divided into four groups that received a control diet supplemented with peanut oil (control), or peanut oil containing a 100-fold increase in vitamin A (HA), or a 100-fold increase in vitamin A and a fivefold increase in vitamin D (HAMD), or a 100-fold increase in vitamin A and a 65-fold increase in vitamin D (HAHD) over a period of 18 months. Cats did not show abnormal locomotion or clinical signs of liver failure after 18 months of supplementation but did show subtle skeletal changes and liver pathology, suggesting that the current National Research Council (2006) safe upper limit for vitamin A for cats is too high. The addition of vitamin D did not seem to influence bone pathology. While moderately elevated dietary vitamin D levels (HAMD) seemed to protect cats against the liver pathology caused by the consumption of large amounts of vitamin A, higher dietary levels of vitamin D (HAHD) did not seem to be protective.
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- 2014
11. Population genetic analysis and genome-wide association study of patellar luxation in a Thai population of Pomeranian dogs
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CSCA AVM, CSCA TR1, dCSCA RMSC-1, dCSCA AVR, Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Techakumphu, M, Hazewinkel, H A W, CSCA AVM, CSCA TR1, dCSCA RMSC-1, dCSCA AVR, Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Techakumphu, M, and Hazewinkel, H A W
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- 2017
12. Enriching the bovine microsatellite Radiation Hybrid map with AFLP® markers
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Gorni, C., Ajmone-Marsan, P., Eijk, M. J. T., Zevenbergen, M., Heuven, H., Negrini, R., Waddington, D., John Williams, and Peleman, J.
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molecular markers, high density map, cattle ,food and beverages ,lcsh:Animal culture ,lcsh:SF1-1100 - Abstract
Genomic maps of ordered markers and expressed sequences are basic tools for the identification and positional cloning of QTLs and genes involved in economic traits in farm animals. The analysis of donor/hamster Radiation Hybrid (RH) panels represent a powerful method to map genes ESTs and markers. RH maps are generally characterised and anchored to linkage maps using SSR markers employing a quite large experimental effort. In addition, the number of available SSRs may in some case be insufficient to assemble complete RH maps, particularly in high-resolution panels. We have adapted the high-throughput AFLP® technology (Vos et al., 1995) to the typing of RH cell lines, and have used it to increase the number of anchor points in the bovine RH map.
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- 2011
13. Prevalence and genetics of patellar luxation in Kooiker dogs
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Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Meutstege, F J, Meij, B P, Hazewinkel, H A W, Onderzoek, Universitair Veterinair Diagnostisch Lab, LS Algemene chirurgie, Sub Neuro Chirurgie, Sub Neuro/Tandheelkunde, Tissue Repair, CSCA TR1, CSCA AVM, Onderzoek, Universitair Veterinair Diagnostisch Lab, LS Algemene chirurgie, Sub Neuro Chirurgie, Sub Neuro/Tandheelkunde, Tissue Repair, CSCA TR1, and CSCA AVM
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Male ,Genome-wide association study ,breed ,Offspring ,Patellar Dislocation ,Population ,Inheritance Patterns ,Pedigree chart ,Patellar luxation ,Biology ,Animal Breeding and Genomics ,Breeding ,size ,Polymorphism, Single Nucleotide ,Canine ,Cohort Studies ,Heritability ,Dogs ,Species Specificity ,Prevalence ,Animals ,Fokkerij en Genomica ,Dog Diseases ,education ,Genetics ,education.field_of_study ,General Veterinary ,Kooiker dog ,Confidence interval ,Breed ,Relative risk ,frequency ,Cohort ,WIAS ,Animal Science and Zoology ,Female - Abstract
The prevalence of patellar luxation (PL) and genetic factors potentially involved in the disorder were investigated in Dutch Kooiker dogs. A cohort of 842 Kooiker dogs, the offspring of 195 sires and 318 dams, was screened for PL from 1994 to 2011. The cohort was included in a pedigree of 1737 Kooiker dogs comprising nine generations. PL was present in 24% of screened dogs, with unilateral and bilateral luxation being observed equally frequently. Medial PL was more common (61%) than lateral PL (32%) or bidirectional PL (7%). The frequency of PL was similar in male and female dogs, with a female:male relative risk of 1.15 (95% confidence interval, CI, 0.90-1.48). The heritability of PL in the screened population was 0.27 +/- 0.07. Since the start of the screening programme, the prevalence of PL decreased from 28% to 19%. A genome-wide association study of PL with 48 cases and 42 controls suggested the possible involvement of a region on chromosome 3 (P-raw = 1.32 x10(-5), P-genome = 0.142), but the involvement of this region could not be confirmed in a validation group. Breeding programmes for complex diseases, such as PL, would benefit from combining pedigrees, phenotypes and genotypes, i.e. from genomic selection, as is currently the method of choice for breeding of production animals. (C) 2014 Elsevier Ltd. All rights reserved.
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- 2014
14. Bayesian Analysis of Heterogeneous Residual Variance in Canine Behaviour
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Stéphanie van den Berg, Inga Schwabe, Fikse, W. F., Heuven, H. C. M., Glas, Cornelis A. W., and Faculty of Behavioural, Management and Social Sciences
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METIS-307771 ,IR-93489 - Abstract
Non-additive effects like for instance genotype-environment interactions and genetically structured heterogeneity of residual variance are notoriously dependent on scale: many statistical non-additive phenomena disappear after a careful choice of transformation of the phenotypic values. Particularly for behavioural measures, scale is a delicate matter. We present a novel Bayesian approach that assesses heterogeneity in environmental variance as a function of genetic effects, where the scale is defined by a psychometric model based on item-response theory. This makes analysis results independent of what items are in a particular test version. We apply the method to fearful behaviour in dogs and compare results with the more usual sum score approach
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- 2014
15. New Strategic Research Agenda: other farm and companion animals breeding
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Bienefeld, K, Nielsen, Vivi Hunnicke, Boiti, C, Heuven, H, and Zeilmaker, F
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- 2011
16. Evaluation of the C-BARQ as a measure of stranger-directed aggression in three common dog breeds
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Stéphanie van den Berg, Heuven, H. C. M., Den Berg, L., Duffy, D. L., Serpell, J. A., Advances in Veterinary Medicine, and Geneeskunde van gezelschapsdieren
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Aggression ,C-BARQ ,METIS-272346 ,IRT ,item response theory ,Rasch ,Canine - Abstract
Volume 124, Issue 3, Pages 136-141 (May 2010) 8 of 12 Evaluation of the C-BARQ as a measure of stranger-directed aggression in three common dog breeds Stéphanie M. van den Berga, Henri C.M. Heuvenb1, Linda van den Bergc2, Deborah L. Duffyd3, James A. Serpelld3 Accepted 11 February 2010. published online 16 March 2010 Abstract Most test development in animal behaviour research is based on classical test theory. Modern test theory, also known as item-response theory, has however a number of advantages. Here, item-response theory was applied to confirm the stranger-directed aggression subscale of the Canine Behavioral Assessment and Research Questionnaire (C-BARQ). The sample consisted of a total of 1000 German Shepherds, Golden Retrievers and Labrador Retrievers. Results showed a good fit for a 1-parameter (Rasch) model. Although there were statistically significant violations of the measurement invariance assumption across breeds, the violations were only minor and without practical consequence. It is therefore concluded that the subscale consisting of 10 items can be used to quantify stranger-directed aggression in these three breeds, and that scores of different dogs can be compared meaningfully regardless of the dogs’ sex, breed or neutering status. Keywords: Item Response Theory, IRT, Rasch, C-BARQ, Canine, Aggression a University of Twente, Faculty of Behavioural Sciences, Department of Research Methodology, Measurement and Data Analysis, P.O. Box 217, 7500 AE Enschede, The Netherlands b Utrecht University, Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals, P.O. Box 80163, 3508 TD Utrecht, The Netherlands c Leiden University Medical Center, Department of Pediatrics and Department of Human Genetics, S4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands d University of Pennsylvania, School of Veterinary Medicine, Department of Clinical Studies VHUP, Philadelphia, PA 19104-6010, USA Corresponding author. Tel.: +31 53 489 2422; fax: +31 53 489 4239. 1 Tel.: +31 30 2539782. 2 Tel.: +31 71 526 9400. 3 Tel.: +1 21 5898 1004. PII: S0168-1591(10)00069-9 doi:10.1016/j.applanim.2010.02.005 © 2010 Elsevier B.V. All rights reserved
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- 2010
17. Prevalence and genetics of patellar luxation in Kooiker dogs
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Onderzoek, Universitair Veterinair Diagnostisch Lab, LS Algemene chirurgie, Sub Neuro Chirurgie, Sub Neuro/Tandheelkunde, Tissue Repair, CSCA TR1, CSCA AVM, Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Meutstege, F J, Meij, B P, Hazewinkel, H A W, Onderzoek, Universitair Veterinair Diagnostisch Lab, LS Algemene chirurgie, Sub Neuro Chirurgie, Sub Neuro/Tandheelkunde, Tissue Repair, CSCA TR1, CSCA AVM, Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Meutstege, F J, Meij, B P, and Hazewinkel, H A W
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- 2014
18. Skeletal and hepatic changes induced by chronic vitamin A supplementation in cats
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LS Algemene chirurgie, Sub Neuro/Tandheelkunde, Veterinair Pathologisch Diagnostisch Cnt, PB AVM, Dep Pathobiologie, Onderzoek, Sub Biochemie Algemeen, Diagnostische beeldvorming, Beheer, LS Veterinaire biochemie, Advances in Veterinary Medicine, Corbee, R J, Tryfonidou, M A, Grinwis, G C M, Schotanus, B, Molenaar, M R, Voorhout, G, Vaandrager, A B, Heuven, H C M, Hazewinkel, H A W, LS Algemene chirurgie, Sub Neuro/Tandheelkunde, Veterinair Pathologisch Diagnostisch Cnt, PB AVM, Dep Pathobiologie, Onderzoek, Sub Biochemie Algemeen, Diagnostische beeldvorming, Beheer, LS Veterinaire biochemie, Advances in Veterinary Medicine, Corbee, R J, Tryfonidou, M A, Grinwis, G C M, Schotanus, B, Molenaar, M R, Voorhout, G, Vaandrager, A B, Heuven, H C M, and Hazewinkel, H A W
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- 2014
19. Utilization of AFLP for genetic distance analysis in pigs
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Heuven, H., Plastow, G., Peleman, J., Siggens, K., Brugmanns, B., and Bagga, M.
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- 2003
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20. Introgression from Domestic Goat Generated Variation at the Major Histocompatibility Complex of Alpine Ibex
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Grossen C., Keller L., Biebach I., Zhang W., Tosser-Klopp G., Ajmone P., Amills M., Boitard S., Chen W., Cheng S., Dong Y., Faraut T., Faruque O., Heuven H., Jinshan Z., Jun L., Lenstra H., Li X., Liu X., Moreno C., Mulsant P., Pan S., Poli M.A., Ren L., Rui S., Rupp R., Cristobal M.S., Sayre B.L., Servin B., Shi P., Song C., Stella A., Valentini A., Xianglong L., XU X., Yanjun Z., Ye C., Yu J., Zhang B., Zhao S., Croll D., Department of Zoology, Auburn University (AU), Institute of Evolutionary Biology and Environmental Studies, Universität Zürich [Zürich] = University of Zurich (UZH), Kunming Institute of Zoology, State Key Laboratory of Genetic Resources and Evolution, Chinese Academy of Sciences [Changchun Branch] (CAS), University of British Columbia (UBC), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Chinese Academy of Sciences (CAS), Swiss National Science Foundation [PBLAP3-14584, PA00P3_145360], Swiss Federal Office for the Environment, University of Zurich, and Grossen, Christine
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Evolutionary Genetics ,0106 biological sciences ,haplotype ,Cancer Research ,Introgression ,[SDV]Life Sciences [q-bio] ,HLA-DR beta-Chains ,Balancing selection ,01 natural sciences ,Linkage Disequilibrium ,Major Histocompatibility Complex ,Natural Selection ,1306 Cancer Research ,chromosome ,Genome Evolution ,Phylogeny ,Genetics (clinical) ,Genetics ,Evolutionary Theory ,0303 health sciences ,biology ,Goats ,loci ,Chromosomal region ,590 Animals (Zoology) ,Research Article ,Gene Flow ,2716 Genetics (clinical) ,Evolutionary Processes ,Capra ibex ,intron ,lcsh:QH426-470 ,chèvre ,Immunology ,complexe majeur d'histocompatibilité ,Locus (genetics) ,010603 evolutionary biology ,10127 Institute of Evolutionary Biology and Environmental Studies ,03 medical and health sciences ,1311 Genetics ,Genetic variation ,1312 Molecular Biology ,Animals ,Allele ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,030304 developmental biology ,Evolutionary Biology ,Polymorphism, Genetic ,Base Sequence ,Genetic Drift ,Haplotype ,Biology and Life Sciences ,Computational Biology ,allèle ,Sequence Analysis, DNA ,DNA sequence ,genetic association ,biology.organism_classification ,lcsh:Genetics ,1105 Ecology, Evolution, Behavior and Systematics ,Haplotypes ,Genetic Polymorphism ,570 Life sciences ,Clinical Immunology ,Population Genetics ,Microsatellite Repeats - Abstract
The major histocompatibility complex (MHC) is a crucial component of the vertebrate immune system and shows extremely high levels of genetic polymorphism. The extraordinary genetic variation is thought to be ancient polymorphisms maintained by balancing selection. However, introgression from related species was recently proposed as an additional mechanism. Here we provide evidence for introgression at the MHC in Alpine ibex (Capra ibex ibex). At a usually very polymorphic MHC exon involved in pathogen recognition (DRB exon 2), Alpine ibex carried only two alleles. We found that one of these DRB alleles is identical to a DRB allele of domestic goats (Capra aegagrus hircus). We sequenced 2489 bp of the coding and non-coding regions of the DRB gene and found that Alpine ibex homozygous for the goat-type DRB exon 2 allele showed nearly identical sequences (99.8%) to a breed of domestic goats. Using Sanger and RAD sequencing, microsatellite and SNP chip data, we show that the chromosomal region containing the goat-type DRB allele has a signature of recent introgression in Alpine ibex. A region of approximately 750 kb including the DRB locus showed high rates of heterozygosity in individuals carrying one copy of the goat-type DRB allele. These individuals shared SNP alleles both with domestic goats and other Alpine ibex. In a survey of four Alpine ibex populations, we found that the region surrounding the DRB allele shows strong linkage disequilibria, strong sequence clustering and low diversity among haplotypes carrying the goat-type allele. Introgression at the MHC is likely adaptive and introgression critically increased MHC DRB diversity in the genetically impoverished Alpine ibex. Our finding contradicts the long-standing view that genetic variability at the MHC is solely a consequence of ancient trans-species polymorphism. Introgression is likely an underappreciated source of genetic diversity at the MHC and other loci under balancing selection., PLoS Genetics, 10 (6), ISSN:1553-7390, ISSN:1553-7404
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- 2014
21. Associations between osteochondrosis and conformation and locomotive characteristics in pigs1
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de Koning, D. B., primary, van Grevenhof, E. M., additional, Laurenssen, B. F. A., additional, Ducro, B. J., additional, Heuven, H. C. M., additional, de Groot, P. N., additional, Hazeleger, W., additional, and Kemp, B., additional
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- 2012
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22. Genetic and nongenetic variation in plasma and milk β-hydroxybutyrate and milk acetone concentrations of early-lactation dairy cows
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van der Drift, S G A, van Hulzen, K J E, Teweldemedhn, T G, Jorritsma, R, Nielen, M, Heuven, H C M, Sub GZ Herkauwer, Sub Junior Docenten, LS Evidence Based Vet Medicine, Onderzoek, Advances in Veterinary Medicine, Sub GZ Herkauwer, Sub Junior Docenten, LS Evidence Based Vet Medicine, Onderzoek, and Advances in Veterinary Medicine
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Cattle Diseases ,health disorders ,Animal Breeding and Genomics ,Biology ,Selective breeding ,Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3] ,Acetone ,metabolic predictors ,chemistry.chemical_compound ,Quantitative Trait ,Quantitative Trait, Heritable ,Lactation ,Genetic variation ,body-weight ,Genetics ,medicine ,Animals ,Fokkerij en Genomica ,Food science ,Heritable ,subclinical ketosis ,parameters ,3-Hydroxybutyric Acid ,food and beverages ,Genetic Variation ,Ketosis ,Heritability ,yield ,medicine.disease ,energy-balance ,medicine.anatomical_structure ,Milk ,Phenotype ,chemistry ,cattle ,WIAS ,Herd ,Ketone bodies ,Animal Science and Zoology ,Cattle ,Female ,feed-intake ,holstein cows ,Food Science - Abstract
Item does not contain fulltext This study assessed genetic variation, heritability estimates, and genetic correlations for concentrations of plasma beta-hydroxybutyrate (BHBA), milk BHBA, and milk acetone in early lactation to investigate differences between cows in susceptibility to hyperketonemia and possibilities to use test-day milk ketone bodies for genetic improvement. Blood and test-day milk samples were collected on randomly selected dairy farms in the Netherlands from cows of various parities between 5 and 60 d in milk. Plasma samples were analyzed for BHBA (reference test for hyperketonemia) and test-day milk samples were analyzed for BHBA and acetone using Fourier-transform infrared spectroscopy. The final data set consisted of plasma BHBA concentrations of 1,615 cows from 122 herds. Milk BHBA and milk acetone concentrations were determined for 1,565 cows. Genetic variation, heritability, and proportion of phenotypic variation attributable to the herd were estimated using an animal model with fixed effects for parity and season, a covariate for days in milk, and random effects for herd, animal, and error. Genetic correlations for plasma BHBA, milk BHBA, and milk acetone were estimated using bivariate analyses. The heritability estimate for plasma BHBA concentrations in early lactation was 0.17, whereas heritability estimates for milk BHBA and milk acetone were 0.16 and 0.10, respectively. This indicates that selective breeding may contribute to a lower incidence of hyperketonemia in early lactation. For the 3 traits, the proportion of variance attributable to herd was larger than the additive genetic variance, underlining the importance of on-farm feeding and management in the etiology of hyperketonemia in fresh cows. Prevention strategies for hyperketonemia can, therefore, include both feeding and management strategies at dairy farms (short-term) and genetic improvement through breeding programs (long-term). Genetic correlations between concentrations of plasma BHBA and milk BHBA (0.52) or milk acetone (0.52) were moderate. As milk ketone bodies can be routinely analyzed at test days, this may provide a practical alternative for breeding programs aimed at reducing hyperketonemia in early lactation.
- Published
- 2012
23. Erratum to “Genetic parameters of insect bite hypersensitivity in Dutch Friesian broodmares” (J. Anim. Sci. 89:1286–1293)
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Schurink, A., primary, Ducro, B. J., additional, Heuven, H. C. M., additional, and van Arendonk, J. A. M., additional
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- 2011
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24. Genetic parameters of insect bite hypersensitivity in Dutch Friesian broodmares1
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Schurink, A., primary, Ducro, B. J., additional, Heuven, H. C. M., additional, and van Arendonk, J. A. M., additional
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- 2011
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25. Utilización de los AFLP(C) para el análisis de distancias genéticas en cerdos
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Plastow, G., Siggens, K., Bagga, M., Brugmans, B., Heuven, H., Peleman, J., Plastow, G., Siggens, K., Bagga, M., Brugmans, B., Heuven, H., and Peleman, J.
- Abstract
Los AFLPs han sido utilizados con éxito como herramienta para generar un gran número (más de cien) de marcadores de ADN en 2435 individuos del proyecto Europeo sobre Biodiversidad Porcina. Esta información fue utilizada para realizar un análisis inicial de distancias genéticas que permitió agrupar líneas y razas según sugería la información descriptiva.
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- 2003
26. Identification of environmental factors affecting the prevalence of insect bite hypersensitivity in Shetland ponies and Friesian horses in the Netherlands
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GREVENHOF, E. M., primary, DUCRO, B., additional, HEUVEN, H. C. M., additional, and BIJMA, P., additional
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- 2007
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27. Variance component analysis of quantitative trait loci for pork carcass composition and meat quality on SSC4 and SSC111
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van Wijk, H. J., primary, Buschbell, H., additional, Dibbits, B., additional, Liefers, S.C., additional, Harlizius, B., additional, Heuven, H. C. M., additional, Knol, E. F., additional, Bovenhuis, H., additional, and Groenen, M. A. M., additional
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- 2007
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28. Phenotypic and genetic evaluation of elbow dysplasia in Dutch Labrador Retrievers, Golden Retrievers, and Bernese Mountain dogs.
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Lavrijsen, I. C. M., Heuven, H. C. M., Voorhout, G., Meij, B. P., Theyse, L. F. H., Leegwater, P. A. J., and Hazewinkel, H. A. W.
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ANIMAL diseases , *DYSPLASIA , *OSTEOARTHRITIS , *LABRADOR retriever , *GOLDEN retriever , *BERNESE mountain dog - Abstract
Canine elbow dysplasia encompasses four developmental diseases: ununited anconeal process, osteochondrosis of the medial part of the humeral condyle, fragmented medial coronoid process (FCP), and incongruity of the elbow joint. Four radiographic views per joint were used to evaluate 2693 Labrador Retrievers (LRs), 1213 Golden Retrievers (GRs), and 974 Bernese Mountain Dogs (BMDs) for the presence of elbow dysplasia between 2002 and 2009 in the Netherlands. The views were also graded for signs of osteoarthritis and sclerosis. FCP was diagnosed most frequently in LRs, GRs and BMDs, with an incidence of 6%, 5%, and 15%, and a heritability of 0.17, 0.24, and 0.06, respectively. Heritabilities were estimated using a sire model and all available ancestors. Sclerosis at the base of the medial coronoid process was the radiographic sign most strongly correlated with FCP (r = 0.95, 0.92, and 0.95 in LRs, GRs and BMDs, respectively). The sex of the dog was significantly correlated with the presence of osteoarthritis in LRs, but not in GRs and BMDs. Male LRs were 1.7-fold more frequently, but not more severely, affected by osteoarthritis than female dogs. Age at radiographic examination was significantly associated with osteoarthritis in all three breeds. The heritability estimates in Retrievers were high enough to warrant including FCP findings in the breeding policy, but until the biomechanical and genetic background of elbow dysplasia are better understood, correct phenotyping with a sensitive technique is essential. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
29. Evidence of Inheritance of Intrahepatic Portosystemic Shunts in Irish Wolfhounds.
- Author
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Van Steenbeek, F. G., Leegwater, P. A. J., Van Sluijs, F. J., Heuven, H. C. M., and Rothuizen, J.
- Subjects
IRISH wolfhound ,AMMONIA ,PUPPIES ,ULTRASONIC imaging ,ANIMAL pedigrees ,GENETIC disorders in animals - Abstract
Background: The etiogenesis of congenital portosystemic shunt in dogs is not understood. In Irish Wolfhounds, intrahepatic portosystemic shunt (IHPSS) is thought to be hereditary, but the mode of inheritance is unknown. Objectives: To document the genetic background and investigate the potential mode of inheritance of IHPSS in Irish Wolfhounds. Animals: Three mature, privately owned, affected siblings and their progeny produced in 2 litters. Methods: Prospective, observational study. Two test matings of 1 affected sire with 2 of his affected sisters were used to determine the inheritance pattern. Affection status was determined by measuring venous blood ammonia concentrations, detection of the shunt by ultrasonography and confirmation during surgical attenuation of the intrahepatic shunting vessel. Results: In 1 litter of 5 pups all had an IHPSS. In the other litter 5 of 11 pups were affected. Both left- and right-sided shunts occurred in both litters. No sex predisposition was evident among affected dogs. Conclusions and Clinical Importance: Our results show that IHPSS in Irish Wolfhounds is a familial disorder that is likely genetic. It is unlikely that the mode of inheritance is monogenic. A digenic, triallelic trait could explain the observed occurrence of IHPSS but other modes of inheritance cannot be excluded. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
30. Amerikaanse ervaringen leren dat uiergezondheidscontrole loont
- Author
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Politiek, R.D. and Heuven, H.
- Subjects
Fokkerij en Genomica ,Animal Breeding and Genomics - Published
- 1984
31. Uiergezondheid in de praktijk, rapport voor de praktijk
- Author
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Heuven, H.
- Subjects
Life Science ,Fokkerij en Genomica ,Animal Breeding and Genomics - Published
- 1985
32. Melkcelgetal Zuid Holland; tussentijdsverslag van een werkcommissie
- Author
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Heuven, H.
- Subjects
Life Science ,Fokkerij en Genomica ,Animal Breeding and Genomics - Published
- 1985
33. Selectie tegen mastitis lijkt mogelijk
- Author
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Heuven, H. and Moesker, S.
- Subjects
Life Science - Published
- 1988
34. Phenotypic and genetic relationships of bovine natural antibodies binding keyhole limpet hemocyanin in plasma and milk.
- Author
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de Klerk, B., Ducro, B. J., Heuven, H. C. M., den Uyl, I., van Arendonk, J. A. M., Parmentier, H. K., and van der Poel, J. J.
- Subjects
- *
IMMUNOGLOBULIN genetics , *HEMOCYANIN , *DAIRY cattle physiology , *BLOOD pigments , *COMPOSITION of milk - Abstract
To improve the health status (resilience) of dairy cows, levels of natural antibodies (NAb) might be useful. The objective of the present study was to compare levels and to estimate genetic parameters for NAb measured in milk and plasma samples. Titers of NAb IgM and IgG isotype-binding keyhole limpet hemocyanin of 2,919 cows, in both plasma and milk, were measured using ELISA. Analysis revealed that NAb levels in milk significantly increased with parity, whereas they remained constant in plasma. Moderate positive phenotypic correlations were found between NAb levels in milk and in plasma: 0.18 for IgG and 0.40 for IgM. This indicates that NAb from milk and plasma might reflect different aspects of dairy cow health status. However, high genetic correlations were found for NAb in milk and plasma: 0.81 for IgG and 0.79 for IgM. Heritabilities (SE in parentheses) for NAb measured in plasma [0.15 (0.05) for IgG and 0.25 (0.06) for IgM] were higher than heritabilities of NAb measured in milk [0.08 (0.03) for IgG and 0.23 (0.05) for IgM]. Our results indicate that NAb measured in milk and plasma are heritable and likely have a common genetic background, suggesting that NAb levels measured in milk might be useful for genetic improvement of disease resistance. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
35. The effect of genetic selection for Johne's disease resistance in dairy cattle: Results of a genetic-epidemiological model.
- Author
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van Hulzen, K. J. E., Koets, A. P., Nielen, M., Heuven, H. C. M., van Arendonk, J. A. M., and Klinkenberg, D.
- Subjects
- *
PARATUBERCULOSIS , *DAIRY cattle , *LIVESTOCK diseases , *MILK contamination , *EPIDEMIOLOGY , *COW diseases , *CATTLE - Abstract
The objective of this study was to model genetic selection for Johne's disease resistance and to study the effect of different selection strategies on the prevalence in the dairy cattle population. In the Netherlands, a certification-and-surveillance program is in use to reduce prevalence and presence of sources of infection in milk by culling ELISA-positive dairy cows in infected herds. To investigate the additional genetic effect of this program, a genetic-epidemiological model was developed to assess the effect of selection of cows that test negative for Johne's disease (dam selection). The genetic effect of selection at the sire level was also considered (sire selection), assuming selection of 80% of sires producing the most resistant offspring based on their breeding values, as well as the combined effect. Parameters assumed to be affected by genetic selection were the length of the latent period, susceptibility (i.e., the number of infectious doses needed to become infected), or the length of susceptible period as a calf. The effect of selection was measured by the time in years required to eliminate infection. Sensitivity analysis was performed for heritability, accuracy of selection, and intensity of selection. For dam selection, responses to selection were small, requiring 379 to 702 yr for elimination. For sire selection, responses were much larger, although elimination still required 147 to 223 yr. The response to selection was largest if genetic selection affected the length of the susceptible period, followed by the susceptibility, and finally the length of the latent period. Genetic selection for Johne's disease resistance by certification and surveillance is too slow for practical purpose, but that selection on the sire level is able to contribute to the control of Johne's disease in the long run. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
36. Genetic variation for infection status as determined by a specific antibody response against Mycobacterium avium subspecies paratuberculosis in milk of Dutch dairy goats.
- Author
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van Hulzen, K. J. E., Koets, A. P., Nielen, M., Hoeboer, J., van Arendonk, J. A. M., and Heuven, H. C. M.
- Subjects
- *
MYCOBACTERIUM avium paratuberculosis , *MYCOBACTERIUM avium , *GOAT milk yield , *GOAT milk , *PARATUBERCULOSIS , *CATTLE - Abstract
Classical control strategies based on management restrictions to reduce transmission, culling of infected goats, and vaccination have not been able to eradicate Johne's disease from infected herds. Selective breeding for less susceptibility to disease may be a useful additional tool to contribute to control of the disease. The aim of this study was to estimate genetic variation and heritability for infection status as determined by a specific antibody response against Mycobacterium avium subspecies paratuberculosis in milk of Dutch dairy goats. Milk samples from 950 goats were tested for antibodies specific to Johne's disease by ELISA on 5 consecutive test days, with a time interval of around 3 mo. Test results were coded as infected or not infected according to the instructions of the manufacturer. Heritability of infection status was estimated for 3 data sets to determine the effect of repeated sampling: only test results obtained on the first test day (first-test); the maximum test result of each animal obtained on 1 of the 5 test days (max-test); and all test results per animal, with a maximum of 5 consecutive samplings (alltest). Data sets first-test and max-test were analyzed with a sire model with fixed effects for year of birth and stage of lactation, and random effects for sire and error. For data set all-test, an additional permanent environment effect was included in the model. The estimated heritability on the underlying scale ranged from 0.12 in data set first-test, to 0.09 in data set max-test, to 0.07 in data set all-test. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
37. Genome-wide association study to identify chromosomal regions associated with antibody response to Mycobacterium avium subspecies paratuberculosis in milk of Dutch Holstein-Friesians.
- Author
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Van Hulzen, K. J. E., Schopen, G. C. B., Van Arendonk, J. A. M., Nielen, M., Koets, A. P., Schrooten, C., and Heuven, H. C. M.
- Subjects
- *
CATTLE diseases , *PARATUBERCULOSIS , *MYCOBACTERIAL diseases in animals , *ENZYME-linked immunosorbent assay , *HOLSTEIN-Friesian cattle - Abstract
Heritability of susceptibility to Johne's disease in cattle has been shown to vary from 0.041 to 0.159. Although the presence of genetic variation involved in susceptibility to Johne's disease has been demonstrated, the understanding of genes contributing to the genetic variance is far from complete. The objective of this study was to contribute to further understanding of genetic variation involved in susceptibility to Johne's disease by identifying associated chromosomal regions using a genome-wide association approach. Log-transformed ELISA test results of 265,290 individual Holstein-Friesian cows from 3,927 herds from the Netherlands were analyzed to obtain sire estimated breeding values for Mycobacterium avium subspecies paratuberculosis (MAP)-specific antibody response in milk using a sire-maternal grandsire model with fixed effects for parity, year of birth, lactation stage, and herd; a covariate for milk yield on test day; and random effects for sire, maternal grandsire, and error. For 192 sires with estimated breeding values with a minimum reliability of 70%, single nucleotide polymorphism (SNP) typing was conducted by a multiple SNP analysis with a random polygenic effect fitting 37,869 SNP simultaneously. Five SNP associated with MAP-specific antibody response in milk were identified distributed over 4 chromosomal regions (chromosome 4, 15, 18, and 28). Thirteen putative SNP associated with MAP-specific antibody response in milk were identified distributed over 10 chromosomes (chromosome 4, 14, 16, 18, 19, 20, 21, 26, 27, and 29). This knowledge contributes to the current understanding of genetic variation involved in Johne's disease susceptibility and facilitates control of Johne's disease and improvement of health status by breeding. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
38. Genetic diversity in European pigs utilizing amplified fragment length polymorphism markers
- Author
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Guillaume Laval, P. Glodek, R. Cardellino, Alan Archibald, A.P. Rattink, Graham Plastow, Martien A. M. Groenen, Vincenzo Russo, M. Bagga, Henri C M Heuven, Amparo Martínez Martínez, J. Peleman, B. Brugmans, Juan Vicente Delgado, Chris Haley, R. Joosten, K. Hammond, L. Alderson, Maria Ramos, E. Fimland, Barbara Harlizius, J. N. Meyer, K. Siggens, Andy Law, Donato Matassino, Roberta Davoli, George C. Russell, Claude Chevalet, Gustavo Gandini, Y. Amigues, Magali SanCristobal, C. Désautés, David J. Milan, Jose Luis Vega-Pla, M.-Y. Boscher, M. G. M. van Schriek, ProdInra, Migration, San Cristobal M., Chevalet C., Peleman J., Heuven H., Brugmans B., Van Schriek M., Joosten R., Rattink A.P., Harlizius B., Groenen M.A.M., Amigues Y., Boscher M.-Y, Russel G., Law A., Davoli R., Russo V., Desautes C., Alderson L., Fimland E., Bagga M., Delgado J.V., Vega-Pla J., Martinez A.M., Ramos M., Glodeck P., Meyer J.N., Gandini G., Matassino D., Siggens K., Laval G., Archibald A., Milan D., Hammond K., Cardellino R., Haley C., Plastow G., Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), and Institut National de la Recherche Agronomique (INRA)
- Subjects
pig ,Genetic Markers ,0106 biological sciences ,Heterozygote ,Genotype ,Swine ,[SDV]Life Sciences [q-bio] ,AMPLIFIED FRAGMENT LENGTH POLYMORPHISM MARKERS ,Breeding ,Biology ,010603 evolutionary biology ,01 natural sciences ,Loss of heterozygosity ,03 medical and health sciences ,Genetics ,Animals ,Allele ,Alleles ,Phylogeny ,030304 developmental biology ,0303 health sciences ,Genetic diversity ,genetic distance ,Polymorphism, Genetic ,conservation ,food and beverages ,genetic diversity ,General Medicine ,[SDV] Life Sciences [q-bio] ,Europe ,Genetic distance ,Genetic marker ,Microsatellite ,Animal Science and Zoology ,Amplified fragment length polymorphism ,aflp marker ,Microsatellite Repeats - Abstract
The use of DNA markers to evaluate genetic diversity is an important component of the management of animal genetic resources. The Food and Agriculture Organisation of the United Nations (FAO) has published a list of recommended microsatellite markers for such studies; however, other markers are potential alternatives. This paper describes results obtained with a set of amplified fragment length polymorphism (AFLP) markers as part of a genetic diversity study of European pig breeds that also utilized microsatellite markers. Data from 148 AFLP markers genotyped across samples from 58 European and one Chinese breed were analysed. The results were compared with previous analyses of data from 50 microsatellite markers genotyped on the same animals. The AFLP markers had an average within-breed heterozygosity of 0.124 but there was wide variation, with individual markers being monomorphic in 3-98% of the populations. The biallelic and dominant nature of AFLP markers creates a challenge for their use in genetic diversity studies as each individual marker contains limited information and AFLPs only provide indirect estimates of the allelic frequencies that are needed to estimate genetic distances. Nonetheless, AFLP marker-based characterization of genetic distances was consistent with expectations based on breed and regional distributions and produced a similar pattern to that obtained with microsatellites. Thus, data from AFLP markers can be combined with microsatellite data for measuring genetic diversity.
- Published
- 2006
39. Breeding implications resulting from classification of patellae luxation in dogs.
- Author
-
van Grevenhof EM, Hazewinkel HA, and Heuven HC
- Subjects
- Animals, Breeding, Dog Diseases pathology, Dogs classification, Genetic Predisposition to Disease, Patellar Dislocation genetics, Patellar Dislocation pathology, Dog Diseases genetics, Dogs genetics, Patellar Dislocation veterinary
- Abstract
Patellar luxation (PL) is one of the major hereditary orthopaedic abnormalities observed in a variety of dog breeds. When the patellae move sideways out of the trochlear groove, this is called PL. The PL score varies between dogs from normal to very severe. Reducing the prevalence of PL by breeding could prevent surgery, thereby improve welfare. Orthopaedic specialists differentiate between normal and loose patellae, where the patellae can be moved to the edge of the trochlear groove, considering scoring loose patellae as normal in the future. Loose patellae are considered acceptable for breeding so far by the breeding organization. The aim of this study was to analyse the genetic background of PL to decide on the importance of loose patellae when breeding for healthy dogs. Data are available from two dog breeds, that is Flat-coated Retrievers (n = 3808) and Kooiker dogs (n = 794), with a total of 4602 dogs. Results show that loose patellae indicate that dogs are genetically more susceptible to develop PL because family members of the dogs with loose patellae showed more severe PL. In addition, the estimated breeding values for dogs with loose patellae indicate that breeding values of dogs with loose patellae were worse than breeding values obtained for dogs with a normal score. Given these results, it is advised to orthopaedic specialists to continue to score loose patellae as a separate class and to dog breeders to minimize the use of dogs in breeding with a genetically higher susceptibility for PL., (© 2015 Blackwell Verlag GmbH.)
- Published
- 2016
- Full Text
- View/download PDF
40. Prevalence and genetics of patellar luxation in Kooiker dogs.
- Author
-
Wangdee C, Leegwater PA, Heuven HC, van Steenbeek FG, Meutstege FJ, Meij BP, and Hazewinkel HA
- Subjects
- Animals, Breeding, Cohort Studies, Dog Diseases pathology, Dogs, Female, Inheritance Patterns, Male, Patellar Dislocation epidemiology, Patellar Dislocation genetics, Patellar Dislocation pathology, Prevalence, Species Specificity, Dog Diseases epidemiology, Dog Diseases genetics, Genome-Wide Association Study veterinary, Patellar Dislocation veterinary, Polymorphism, Single Nucleotide
- Abstract
The prevalence of patellar luxation (PL) and genetic factors potentially involved in the disorder were investigated in Dutch Kooiker dogs. A cohort of 842 Kooiker dogs, the offspring of 195 sires and 318 dams, was screened for PL from 1994 to 2011. The cohort was included in a pedigree of 1737 Kooiker dogs comprising nine generations. PL was present in 24% of screened dogs, with unilateral and bilateral luxation being observed equally frequently. Medial PL was more common (61%) than lateral PL (32%) or bidirectional PL (7%). The frequency of PL was similar in male and female dogs, with a female:male relative risk of 1.15 (95% confidence interval, CI, 0.90-1.48). The heritability of PL in the screened population was 0.27 ± 0.07. Since the start of the screening programme, the prevalence of PL decreased from 28% to 19%. A genome-wide association study of PL with 48 cases and 42 controls suggested the possible involvement of a region on chromosome 3 (Praw = 1.32 × 10(-)(5), Pgenome = 0.142), but the involvement of this region could not be confirmed in a validation group. Breeding programmes for complex diseases, such as PL, would benefit from combining pedigrees, phenotypes and genotypes, i.e. from genomic selection, as is currently the method of choice for breeding of production animals., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
41. Prevalence and co-occurrence of hip dysplasia and elbow dysplasia in Dutch pure-bred dogs.
- Author
-
Lavrijsen IC, Heuven HC, Meij BP, Theyse LF, Nap RC, Leegwater PA, and Hazewinkel HA
- Subjects
- Animals, Dog Diseases epidemiology, Dog Diseases genetics, Dog Diseases pathology, Dogs, Hip Dysplasia, Canine genetics, Joint Diseases epidemiology, Joint Diseases genetics, Netherlands epidemiology, Dog Diseases etiology, Forelimb pathology, Genetic Predisposition to Disease, Hip Dysplasia, Canine epidemiology, Joint Diseases veterinary
- Abstract
Hip as well as elbow dysplasia (HD, ED) are developmental disorders leading to malformation of their respective joints. For a long time both disorders have been scored and targeted for improvement using selective breeding in several Dutch dog populations. In this paper all scores for both HD and ED, given to pure bred dogs in the Netherlands from 2002 to 2010, were analyzed. Heritabilities and correlations between HD and ED were calculated for the 4 most frequently scored breeds. Heritabilities ranged from 0.0 to 0.37 for HD related traits (FCI-score, osteoarthritis, congruity, shape and laxity (Norberg angle); FCI: Fédération Cynologique Internationale) and from 0.0 to 0.39 for ED related traits (IEWG score, osteoarthritis, sclerosis and indentation; IEWG: International Elbow Working Group). HD related traits showed high genetic and residual correlations among each other but were only to a minor extent correlated with ED related traits, which also showed high correlations among each other. Genetic correlations were higher than residual correlations. Phenotypic and genetic trends since 2001 for the four most scored breeds were slightly positive but decreasing over time, indicating that selection over the past decade has not been effective., (Copyright © 2014. Published by Elsevier B.V.)
- Published
- 2014
- Full Text
- View/download PDF
42. Heritable and non-heritable genetic effects on retained placenta in Meuse-Rhine-Yssel cattle.
- Author
-
Benedictus L, Koets AP, Kuijpers FH, Joosten I, van Eldik P, and Heuven HC
- Subjects
- Alleles, Animals, Animals, Newborn, Cattle, Cattle Diseases epidemiology, Female, Incidence, Male, Pedigree, Placenta, Retained epidemiology, Placenta, Retained genetics, Pregnancy, Regression Analysis, Retrospective Studies, Cattle Diseases genetics, Histocompatibility Antigens Class I genetics, Placenta, Retained veterinary, Quantitative Trait, Heritable
- Abstract
Failure of the timely expulsion of the fetal membranes, called retained placenta, leads to reduced fertility, increased veterinary costs and reduced milk yields. The objectives of this study were to concurrently look at the heritable and non-heritable genetic effects on retained placenta and test the hypothesis that a greater coefficient of relationship between dam and calf increases the risk of retained placenta in the dam. The average incidence of retained placenta in 43,661 calvings of Meuse-Rhine-Yssel cattle was 4.5%, ranging from 0% to 29.6% among half-sib groups. The average pedigree based relationship between the sire and the maternal grandsire was 0.05 and ranged from 0 to 1.04. Using a sire-maternal grandsire model the heritability was estimated at 0.22 (SEM=0.07) which is comparable with estimates for other dual purpose breeds. The coefficient of relationship between the sire and the maternal grandsire had an effect on retained placenta. The coefficient of relationship between the sire and the maternal grandsire was used as a proxy for the coefficient of relationship between dam and calf, which is correlated with the probability of major histocompatibility complex (MHC) class I compatibility between dam and calf. MHC class I compatibility is an important risk factor for retained placenta. Although the MHC class I haplotype is genetically determined, MHC class I compatibility is not heritable. This study shows that selection against retained placenta is possible and indicates that preventing the mating of related parents may play a role in the prevention of retained placenta., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
43. Different Mycobacterium avium subsp. paratuberculosis MIRU-VNTR patterns coexist within cattle herds.
- Author
-
van Hulzen KJ, Heuven HC, Nielen M, Hoeboer J, Santema WJ, and Koets AP
- Subjects
- Animals, Bacterial Typing Techniques methods, DNA, Bacterial genetics, Feces microbiology, Genetic Variation, Genotype, Mycobacterium avium subsp. paratuberculosis classification, Mycobacterium avium subsp. paratuberculosis isolation & purification, Netherlands, Polymerase Chain Reaction, Cattle microbiology, Cattle Diseases microbiology, Minisatellite Repeats, Mycobacterium avium subsp. paratuberculosis genetics, Paratuberculosis microbiology
- Abstract
A better understanding of the biodiversity of Mycobacterium avium subsp. paratuberculosis (MAP) offers more insight in the epidemiology of paratuberculosis and therefore may contribute to the control of the disease. The aim of this study was to investigate the genetic diversity in bovine MAP isolates using PCR-based methods detecting genetic elements called Variable-Number Tandem Repeats (VNTRs) and Mycobacterial Interspersed Repetitive Units (MIRUs) to determine if multiple MAP strains can coexist on farms with endemic MAP infection. For 52 temporal isolates originating from infected cattle from 32 commercial dairy herds with known trading history, MIRU-VNTR analysis was applied at 10 loci of which six showed variation. Within the group of 52 isolates, 17 different MIRU-VNTR patterns were detected. One MIRU-VNTR pattern was found in 29 isolates, one pattern in four isolates, one pattern in three isolates, two times one MIRU-VNTR pattern was found occurring in two isolates, and 12 patterns were found only once. Eleven herds provided multiple isolates. In five herds a single MIRU-VNTR pattern was detected among multiple isolates whereas in six herds more than one pattern was found. This study confirms that between dairy farms as well as within dairy farms, infected animals shed MAP with different MIRU-VNTR patterns. Analysis of trading history and age within herds indicated that cows born within the same birth cohort can be infected with MAP strains exhibiting variations in the number of MIRU-VNTR repeats. These data indicate that such multiple genotypes of MAP can coexist within one herd., (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
44. Effect of herd prevalence on heritability estimates of antibody response to Mycobacterium avium subspecies paratuberculosis.
- Author
-
van Hulzen KJ, Nielen M, Koets AP, de Jong G, van Arendonk JA, and Heuven HC
- Subjects
- Animals, Cattle Diseases prevention & control, Female, Male, Milk immunology, Paratuberculosis prevention & control, Selection, Genetic, Antibody Formation genetics, Cattle genetics, Cattle immunology, Mycobacterium avium subsp. paratuberculosis immunology
- Abstract
Worldwide, classical control strategies based on hygiene and culling of infected animals have been implemented to eradicate Johne's disease. Breeding for disease resistance may be a useful additional tool to control the disease. The aim of this study was to estimate genetic parameters for the presence of a Mycobacterium avium ssp. paratuberculosis specific antibody response in milk of Dutch Holstein-Friesian cows using subsets of data based on within-herd test prevalence. The analyzed data set consisted of milk samples of 684,364 animals from 12,077 herds collected during the routine milk production scheme. Milk samples were tested for antibodies specific for Johne's disease by an ELISA test. Heritability estimates were calculated for 4 different subsets of data to determine the sensitivity of heritability for within-herd test prevalence. Results expressed as percentage of the sample to positive ratio were analyzed with a sire-maternal grandsire model with fixed effects for parity, year of birth, lactation stage, and herd; a covariate for milk yield at test day; and random effects for sire, maternal grandsire, and error. The estimated heritability ranged from 0.031 for the complete data set to 0.097 for herds with a test prevalence of at least 10%. Cross-validation was applied to determine which of the subsets of data produced the most accurate estimated breeding values. Results showed that for genetic selection to contribute to disease control, breeding values were estimated most accurately from herds with at least 2 animals that tested positive. In this subset the heritability was 0.041., (Copyright © 2011 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
45. Identification of environmental factors affecting the prevalence of insect bite hypersensitivity in Shetland ponies and Friesian horses in The Netherlands.
- Author
-
van Grevenhof EM, Ducro B, Heuven HC, and Bijma P
- Subjects
- Animals, Cold Temperature, Female, Horse Diseases epidemiology, Horses, Hypersensitivity epidemiology, Hypersensitivity immunology, Insect Bites and Stings epidemiology, Insect Bites and Stings immunology, Netherlands epidemiology, Prevalence, Rain, Seasons, Skin Diseases epidemiology, Skin Diseases immunology, Ceratopogonidae immunology, Horse Diseases immunology, Hypersensitivity veterinary, Insect Bites and Stings veterinary, Skin Diseases veterinary
- Abstract
Reasons for Performing Study: It is expected that climate and habitat factors influence the prevalence of culicoides and, therefore, the prevalence of insect bite hypersensitivity (IBH), but very little is described in the literature to prove the association of these factors. Prevalence varies widely from 3% in certain areas of Great Britain to 60% in certain parts of Australia., Objectives: To describe the influence of environmental factors on the prevalence of IBH in Shetland ponies and Friesian horses in The Netherlands., Methods: Data on 3284 Shetland and 2824 Friesian mares (n = 6108) were collected in The Netherlands, based on 90 regions, according to postal codes. The climate components, amount of rainfall, number of warm days, number of cold days, and habitat components of soil type and type of vegetation were collected for each region., Results: Prevalence of IBH varied widely from 0-71.4% per region. The results showed that the environment with low IBH-prevalence had high rainfall, many cold days and few warm days per year. Habitats with a low IBH-prevalence were based along the coast line. Habitats with increasing prevalence of IBH had soils of clay with heather and woody vegetation. Friesian mares had a higher IBH prevalence than Shetland mares, which could indicate an effect of genetic background or an effect of year., Conclusions: There is an environmental effect on IBH prevalence within The Netherlands, which is caused by climate and habitat factors., Potential Relevance: The results provide a more accurate description of environmental factors and their impact on development of IBH; and should help better to understand habitat and climate effects, and to distinguish these from other effects, such as animal factors (genetics, age or sex).
- Published
- 2007
- Full Text
- View/download PDF
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