272 results on '"Hewitt, Nicola J."'
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2. Minimizing operator exposure: field data analysis of three closed transfer systems for pesticide mixing and loading
3. Proposals for new spray drift exposure values in orchards and vineyards for residents and bystanders
4. Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards
5. Ambient air concentrations of plant protection products: Data collection for the combined air concentration database and associated risk assessment
6. Protection by ordinary light clothing against pesticide spray drift for bystanders and residents
7. Safety assessment for nail cosmetics: Framework for the estimation of systemic exposure through the nail plate
8. Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data
9. The role of a molecular informatics platform to support next generation risk assessment
10. Measured air concentrations of pesticides for the estimation of exposure to vapour in European risk assessments
11. In silico prediction of dermal absorption from non-dietary exposure to plant protection products
12. Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens
13. Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment
14. A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment
15. Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion.
16. Correction to: Protection by ordinary light clothing against pesticide spray drift for bystanders and residents
17. Use of in vitro metabolomics in NRK cells to help predicting nephrotoxicity and differentiating the MoA of nephrotoxicants
18. Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure
19. Cosmetics Europe evaluation of 6 in silico skin penetration models
20. New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine
21. Correction to: Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data
22. Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model
23. A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals
24. Pesticide Exposure of Operators from Drone Application: A Field Study with Comparative Analysis to Handheld Data from Exposure Models
25. Road Map for Development of Stem Cell-Based Alternative Test Methods
26. Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first‐pass skin metabolism of the hair dye, 4‐amino‐2‐hydroxytoluene.
27. The Use of Toxicokinetic Information for Setting Concentrations of In Vitro Toxicity Tests and for Interpreting Their Results: A Proposed Workflow.
28. Application of a skin and liver Chip2 microphysiological model to investigate the route‐dependent toxicokinetics and toxicodynamics of consumer‐relevant doses of genistein.
29. Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first‐pass skin metabolism of the hair dye, 4‐amino‐2‐hydroxytoluene
30. Application of a skin and liver Chip2 microphysiological model to investigate the route‐dependent toxicokinetics and toxicodynamics of consumer‐relevant doses of genistein
31. ADME characterization and PBK model development of 3 highly protein-bound UV filters through topical application
32. A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
33. Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
34. Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes
35. Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps
36. Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps
37. Dermal measurement of exposure to plant protection products: Actual hand exposure from hand washing vs. wearing cotton gloves
38. Correction to: Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data
39. Proposals for new spray drift exposure values in orchard and vineyards for residents and bystanders.
40. Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data
41. A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation
42. Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application
43. The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: Detailed protocol and harmonized scoring atlas
44. Cryopreservation of Hepatocytes
45. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis
46. International prevalidation studies of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility
47. Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro
48. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Eye irritation
49. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Skin irritation
50. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
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