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2. Electrocardiogram-based mortality prediction in patients with COVID-19 using machine learning

Author

van de Leur, R. R., Bleijendaal, H., Taha, K., Mast, T., Gho, J. M. I. H., Linschoten, M., van Rees, B., Henkens, M. T. H. M., Heymans, S., Sturkenboom, N., Tio, R. A., Offerhaus, J. A., Bor, W. L., Maarse, M., Haerkens-Arends, H. E., Kolk, M. Z. H., van der Lingen, A. C. J., Selder, J. J., Wierda, E. E., van Bergen, P. F. M. M., Winter, M. M., Zwinderman, A. H., Doevendans, P. A., van der Harst, P., Pinto, Y. M., Asselbergs, F. W., van Es, R., and Tjong, F. V. Y.

Published
2022
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4. Aktualizace Doporučení ESC pro diagnostiku a léčbu akutního a chronického srdečního selhání 2021. Vypracovaná Pracovní skupinou pro diagnostiku a léčbu akutního a chronického srdečního selhání Evropské kardiologické společnosti (ESC). Se zvláštním přispěním Evropské asociace srdečního selhání ESC.

Author

TA, McDonagh, primary, Metra, M, additional, Adamo, M, additional, RS, Gardner, additional, Baumbach, A, additional, Böhm, M, additional, Burri, H, additional, Butler, J, additional, Čelutkienė, J, additional, Chioncel, O, additional, JGF, Cleland, additional, MG, Crespo-Leiro, additional, Farmakis, D, additional, Gilard, M, additional, Heymans, S, additional, AW, Hoes, additional, Jaarsma, T, additional, EA, Jankowska, additional, Lainscak, M, additional, CSP, Lam, additional, AR, Lyon, additional, JJV, McMurray, additional, Mebazaa, A, additional, Mindham, R, additional, Muneretto, C, additional, MF, Piepoli, additional, Price, S, additional, GMC, Rosano, additional, Ruschitzka, F, additional, AK, Skibelund, additional, TA, McDonagh, additional, Krejčí, Jan, additional, Špinarová, Lenka, additional, Pařenica, Jiří, additional, Chaloupka, Anna, additional, and Veselý, Jiří, additional

Published
2024
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5. Quality of life and societal costs in patients with dilated cardiomyopathy

Author

Wiethoff, I, Sikking, M, Evers, S, Gabrio, A, Henkens, M, Michels, M, Verdonschot, J, Heymans, S, Hiligsmann, M, Wiethoff, I, Sikking, M, Evers, S, Gabrio, A, Henkens, M, Michels, M, Verdonschot, J, Heymans, S, and Hiligsmann, M

Abstract

Aims Dilated cardiomyopathy (DCM) is a major cause of heart failure impairing patient wellbeing and imposing a substantial economic burden on society, but respective data are missing. This study aims to measure the quality of life (QoL) and societal costs of DCM patients. Met hods a nd results A cross-sectional evaluation of QoL and societal costs of DCM patients was performed through the 5-level EuroQol and the Medical Consumption Questionnaire and Productivity Cost Questionnaire, respectively. QoL was translated into numerical values (i.e. utilities). Costs were measured from a Dutch societal perspective. Final costs were extrapolated to 1 year, reported in 2022 Euros, and compared between DCM severity according to NYHA classes. A total of 550 DCM patients from the Maastricht cardiomyopathy registry were included. Mean age was 61 years, and 34% were women. Overall utility was slightly lower for DCM patients than the population mean (0.840 vs. 0.869, P = 0.225). Among EQ-5D dimensions, DCM patients scored lowest in 'usual activities'. Total societal DCM costs were €14 843 per patient per year. Cost drivers were productivity losses ( €7037) and medical costs ( €4621). Patients with more symptomatic DCM (i.e. NYHA class III or IV) had significantly higher average DCM costs per year compared to less symptomatic DCM ( €31 099 vs. €11 446, P < 0.001) and significantly lower utilities (0.631 vs. 0.883, P < 0.001). Conclusion DCM is associated with high societal costs and reduced QoL, in particular with high DCM severity.

Published
2024

6. Clonal hematopoiesis has prognostic value in dilated cardiomyopathy independent of age and clone size

Author

Sikking, M, primary, Stroeks, S L V, additional, Henkens, M T H, additional, Raafs, A G, additional, Cossin, B, additional, Van Deuren, R, additional, Steehouwer, M, additional, Riksen, N P, additional, Van Den Wijngaard, A, additional, Brunner, H, additional, Hoischen, A, additional, Verdonschot, J A J, additional, and Heymans, S R B, additional

Published
2023
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15. Titin truncating variant cardiomyopathy and related sarcomere insufficiency causes high energy demand resulting in mitochondrial dysfunction, autophagosome formation, and apoptosis

Author

Stroeks, S L V M, primary, Verdonschot, J A J, additional, Lunde, I G, additional, Henkens, M T H M, additional, Willemars, M, additional, Schianchi, F, additional, Luiken, J F P, additional, Wang, P, additional, Derks, K, additional, Krapels, I P C, additional, Vanhoutte, E K, additional, Jones, E A V, additional, Brunner, H G, additional, Nabben, M, additional, and Heymans, S R B, additional

Published
2022
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16. Deletion of the extracellular matrix glycoprotein ADAMTSL3 increases pro-fibrotic signalling and exacerbates heart failure in mice

Author

Rypdal, K, primary, Melleby, A O, additional, Robinson, E L, additional, Palmero, S, additional, Seifert, D, additional, Martin, D, additional, Andreassen, K, additional, Dahl, C P, additional, Sjaastad, I, additional, Toennessen, T, additional, Stokke, M, additional, Heymans, S, additional, Christensen, G, additional, Apte, S, additional, and Lunde, I G, additional

Published
2022
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17. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author

Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, Omerovic E., Citro R., Bossone E., Redfors B., Backs J., Bruns B., Ciccarelli M., Couch L. S., Dawson D., Grassi G., Iacoviello M., Parodi G., Schneider B., Templin C., Ghadri J. R., Thum T., Chioncel O., Tocchetti C. G., Van Der Velden J., Heymans S., Lyon A. R., Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, L, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, J, Thum, T, Chioncel, O, Tocchetti, C, Van Der Velden, J, Heymans, S, Lyon, A, Omerovic E., Citro R., Bossone E., Redfors B., Backs J., Bruns B., Ciccarelli M., Couch L. S., Dawson D., Grassi G., Iacoviello M., Parodi G., Schneider B., Templin C., Ghadri J. R., Thum T., Chioncel O., Tocchetti C. G., Van Der Velden J., Heymans S., and Lyon A. R.

Abstract

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research.

Published
2021

20. A Defeasible Ontology Language

Author

Heymans, S., Vermeir, D., Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Meersman, Robert, editor, and Tari, Zahir, editor

Published
2002
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21. Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries

Author

Linschoten, M., Uijl, A., Schut, A., Jakob, C. E. M., Romao, L. R., Bell, R. M., McFarlane, E., Stecher, M., Zondag, A. G. M., van Iperen, E. P. A., Hermans-van Ast, J. F., Lea, N. C., Schaap, J., Jewbali, L. S., Smits, P. C., Patel, R. S., Aujayeb, A., van Smeden, M., Siebelink, H. J., Williams, S., Pilgram, L., Tieleman, R. G., Williams, B., Asselbergs, F. W., Al-Ali, A. K., Al-Muhanna, F. A., Al-Rubaish, A. M., Al-Windy, N. Y. Y., Alkhalil, M., Almubarak, Y. A., Al Nafie, A. N., Al Shahrani, M., Al Shehri, A. M., Anning, C., Anthonio, R. L., Badings, E. A., Ball, C., Van Beek, E. A., Ten Berg, J. M., Von Bergwelt-Baildon, M., Bianco, M., Blagova, O., V, Bleijendaal, H., Bor, W. L., Borgmann, S., van Boxem, A. J. M., van den Brink, F. S., Bucciarelli-Ducci, C., Van Bussel, B. C. T., Byrom-Goulthorp, R., Captur, G., Caputo, M., Charlotte, N., vom Dahl, J., Dark, P., De Sutter, J., Degenhardt, C., Delsing, C. E., Dolff, S., Dorman, H. G. R., Drost, J. T., Eberwein, L., Emans, M. E., Er, A. G., Ferreira, J. B., Forner, M. J., Friedrichs, A., Gabriel, L., Groenemeijer, B. E., Groenendijk, A. L., Gruener, B., Guggemos, W., Haerkens-Arends, H. E., Hanses, F., Hedayat, B., Heigener, D., van der Heijden, D. J., Hellou, E., Hellwig, K., Henkens, M. T. H. M., Hermanides, R. S., Hermans, W. R. M., van Hessen, M. W. J., Heymans, S. R. B., Hilt, A. D., van der Horst, I. C. C., Hower, M., van Ierssel, S. H., Isberner, N., Jensen, B., Kearney, M. T., Kielstein, J. T., Kietselaer, B. L. J. H., Kochanek, M., Kolk, M. Z. H., Koning, A. M. H., Kopylov, P. Y., Kuijper, A. F. M., Kwakkel-van, E. R. P. J. M., Lanznaster, J., van der Linden, M. M. J. M., van der Lingen, A. C. J., Linssen, G. C. M., Lomas, D., Maarse, M., Magdelijns, F. J. H., Magro, M., Markart, P., Martens, F. M. A. C., Mazzilli, S. G., McCann, G. P., van der Meer, P., Meijs, M. F. L., Merle, U., Messiaen, P., Milovanovic, M., Monraats, P. S., Montagna, L., Moriarty, A., Moss, A. J., Mosterd, A., Nadalin, S., Nattermann, J., Neufang, M., Nierop, P. R., Offerhaus, J. A., Van Ofwegen-Hanekamp, C. E. E., Parker, E., Persoon, A. M., Piepel, C., Pinto, Y. M., Poorhosseini, H., Prasad, S., Raafs, A. G., Raichle, C., Rauschning, D., Redon, J., Reidinga, A. C., Ribeiro, M. I. A., Riedel, C., Rieg, S., Ripley, D. P., Rommele, C., Rothfuss, K., Ruddel, J., Ruthrich, M. M., Salah, R., Saneei, E., Saxena, M., Schellings, D. A. A. M., Scholte, N. T. B., Schubert, J., Seelig, J., Shafiee, A., Shore, A. C., Spinner, C., Stieglitz, S., Strauss, R., Sturkenboom, N. H., Tessitore, E., Thomson, R. J., Timmermans, P. J. R., Tio, R. A., Tjong, F. V. Y., Tometten, L., Trauth, J., Van Craenenbroeck, E. M., van Veen, H. P. A. A., den Uil, C. A., Vehreschild, M. J. G. T., Veldhuis, L., I, Veneman, T., Verschure, D. O., Voigt, I, Walter, L., vande Watering, D. J., de Vries, J. K., vande Wal, R. M. A., Westendorp, I. C. D., Westendorp, P. H. M., Westhoff, T., Weytjens, C., Wierda, E., Wille, K., de With, K., Worm, M., Woudstra, P., Wu, K. W., Zaal, R., Zaman, A. G., van der Zee, P. M., Zijlstra, L. E., Alling, T. E., Ahmed, R., Bayraktar-Verver, E. C. E., van Aken, K., Jimenes, Bermudez F. J., Biole, C. A., Den Boer-Penning, P., Bontje, M., Bos, M., Bosch, L., Broekman, M., Broeyer, F. J. F., de Bruijn, E. A. W., Bruinsma, S., Cardoso, N. M., Cosyns, B., Len, van Da D. H., Dekimpe, E., Domange, J., van Doorn, J. L., van DOorn, P., Dormal, F., Drost, I. M. J., Dunnink, A., van Eck, J. W. M., Elshinawy, K., Gevers, R. M. M., Gognieva, D. G., van der Graaf, M., Grangeon, S., Guclu, A., Habib, A., Haenen, N. A., Hamilton, K., Handgraaf, S., Heidbuchel, H., Hendriks-van Woerden, M., Hessels-Linnemeijer, B. M., Hosseini, K., Huisman, J., Jacobs, T. C., Jansen, S. E., Janssen, A., Jourdan, K., ten Kate, G. L., van Kempen, M. J., Kievit, C. M., Kleikers, P., Knufman, N., van der Kooi, S. E., Koole, B. A. S., Koole, M. A. C., Kui, K. K., Kuipers-Elferink, L., Lemoine, I, Lensink, E., van Marrewijk, V, Meijer, E. J., Melein, A. J., Mesitskaya, D. F., van Nes, C. P. M., Paris, F. M. A., Perrelli, M. G., Pieterse-Rots, A., Pisters, R., Polkerman, B. C., van Poppel, A., Reinders, S., Reitsma, M. J., Ruiter, A. H., Selder, J. L., van der Sluis, A., Sousa, A. I. C., Tajdini, M., Sanchez, Tercedor L., Van de Heyning, C. M., Vial, H., Vlieghe, E., Vonkeman, H. E., Vreugdenhil, P., de Vries, T. A. C., Willems, A. M., Wils, A. M., Zoet-Nugteren, S. K., Linschoten, M., Uijl, A., Schut, A., Jakob, C. E. M., Romao, L. R., Bell, R. M., McFarlane, E., Stecher, M., Zondag, A. G. M., van Iperen, E. P. A., Hermans-van Ast, J. F., Lea, N. C., Schaap, J., Jewbali, L. S., Smits, P. C., Patel, R. S., Aujayeb, A., van Smeden, M., Siebelink, H. J., Williams, S., Pilgram, L., Tieleman, R. G., Williams, B., Asselbergs, F. W., Al-Ali, A. K., Al-Muhanna, F. A., Al-Rubaish, A. M., Al-Windy, N. Y. Y., Alkhalil, M., Almubarak, Y. A., Al Nafie, A. N., Al Shahrani, M., Al Shehri, A. M., Anning, C., Anthonio, R. L., Badings, E. A., Ball, C., Van Beek, E. A., Ten Berg, J. M., Von Bergwelt-Baildon, M., Bianco, M., Blagova, O., V, Bleijendaal, H., Bor, W. L., Borgmann, S., van Boxem, A. J. M., van den Brink, F. S., Bucciarelli-Ducci, C., Van Bussel, B. C. T., Byrom-Goulthorp, R., Captur, G., Caputo, M., Charlotte, N., vom Dahl, J., Dark, P., De Sutter, J., Degenhardt, C., Delsing, C. E., Dolff, S., Dorman, H. G. R., Drost, J. T., Eberwein, L., Emans, M. E., Er, A. G., Ferreira, J. B., Forner, M. J., Friedrichs, A., Gabriel, L., Groenemeijer, B. E., Groenendijk, A. L., Gruener, B., Guggemos, W., Haerkens-Arends, H. E., Hanses, F., Hedayat, B., Heigener, D., van der Heijden, D. J., Hellou, E., Hellwig, K., Henkens, M. T. H. M., Hermanides, R. S., Hermans, W. R. M., van Hessen, M. W. J., Heymans, S. R. B., Hilt, A. D., van der Horst, I. C. C., Hower, M., van Ierssel, S. H., Isberner, N., Jensen, B., Kearney, M. T., Kielstein, J. T., Kietselaer, B. L. J. H., Kochanek, M., Kolk, M. Z. H., Koning, A. M. H., Kopylov, P. Y., Kuijper, A. F. M., Kwakkel-van, E. R. P. J. M., Lanznaster, J., van der Linden, M. M. J. M., van der Lingen, A. C. J., Linssen, G. C. M., Lomas, D., Maarse, M., Magdelijns, F. J. H., Magro, M., Markart, P., Martens, F. M. A. C., Mazzilli, S. G., McCann, G. P., van der Meer, P., Meijs, M. F. L., Merle, U., Messiaen, P., Milovanovic, M., Monraats, P. S., Montagna, L., Moriarty, A., Moss, A. J., Mosterd, A., Nadalin, S., Nattermann, J., Neufang, M., Nierop, P. R., Offerhaus, J. A., Van Ofwegen-Hanekamp, C. E. E., Parker, E., Persoon, A. M., Piepel, C., Pinto, Y. M., Poorhosseini, H., Prasad, S., Raafs, A. G., Raichle, C., Rauschning, D., Redon, J., Reidinga, A. C., Ribeiro, M. I. A., Riedel, C., Rieg, S., Ripley, D. P., Rommele, C., Rothfuss, K., Ruddel, J., Ruthrich, M. M., Salah, R., Saneei, E., Saxena, M., Schellings, D. A. A. M., Scholte, N. T. B., Schubert, J., Seelig, J., Shafiee, A., Shore, A. C., Spinner, C., Stieglitz, S., Strauss, R., Sturkenboom, N. H., Tessitore, E., Thomson, R. J., Timmermans, P. J. R., Tio, R. A., Tjong, F. V. Y., Tometten, L., Trauth, J., Van Craenenbroeck, E. M., van Veen, H. P. A. A., den Uil, C. A., Vehreschild, M. J. G. T., Veldhuis, L., I, Veneman, T., Verschure, D. O., Voigt, I, Walter, L., vande Watering, D. J., de Vries, J. K., vande Wal, R. M. A., Westendorp, I. C. D., Westendorp, P. H. M., Westhoff, T., Weytjens, C., Wierda, E., Wille, K., de With, K., Worm, M., Woudstra, P., Wu, K. W., Zaal, R., Zaman, A. G., van der Zee, P. M., Zijlstra, L. E., Alling, T. E., Ahmed, R., Bayraktar-Verver, E. C. E., van Aken, K., Jimenes, Bermudez F. J., Biole, C. A., Den Boer-Penning, P., Bontje, M., Bos, M., Bosch, L., Broekman, M., Broeyer, F. J. F., de Bruijn, E. A. W., Bruinsma, S., Cardoso, N. M., Cosyns, B., Len, van Da D. H., Dekimpe, E., Domange, J., van Doorn, J. L., van DOorn, P., Dormal, F., Drost, I. M. J., Dunnink, A., van Eck, J. W. M., Elshinawy, K., Gevers, R. M. M., Gognieva, D. G., van der Graaf, M., Grangeon, S., Guclu, A., Habib, A., Haenen, N. A., Hamilton, K., Handgraaf, S., Heidbuchel, H., Hendriks-van Woerden, M., Hessels-Linnemeijer, B. M., Hosseini, K., Huisman, J., Jacobs, T. C., Jansen, S. E., Janssen, A., Jourdan, K., ten Kate, G. L., van Kempen, M. J., Kievit, C. M., Kleikers, P., Knufman, N., van der Kooi, S. E., Koole, B. A. S., Koole, M. A. C., Kui, K. K., Kuipers-Elferink, L., Lemoine, I, Lensink, E., van Marrewijk, V, Meijer, E. J., Melein, A. J., Mesitskaya, D. F., van Nes, C. P. M., Paris, F. M. A., Perrelli, M. G., Pieterse-Rots, A., Pisters, R., Polkerman, B. C., van Poppel, A., Reinders, S., Reitsma, M. J., Ruiter, A. H., Selder, J. L., van der Sluis, A., Sousa, A. I. C., Tajdini, M., Sanchez, Tercedor L., Van de Heyning, C. M., Vial, H., Vlieghe, E., Vonkeman, H. E., Vreugdenhil, P., de Vries, T. A. C., Willems, A. M., Wils, A. M., and Zoet-Nugteren, S. K.

Abstract

Aims Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality. Methods and results We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66-75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%; n= 1545 vs. 15.9%; n= 1797). However, following multivariable adjustment, this difference was not significant [adjusted risk ratio (aRR) 1.08, 95% confidence interval (CI) 1.02-1.15; P = 0.12 (corrected for multiple testing)]. Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure (aRR 1.19, 95% CI 1.10-1.30; P <0.018) particularly for severe (New York Heart Association class III/IV) heart failure (aRR 1.41, 95% CI 1.20-1.64; P < 0.018). None of the other heart disease subtypes, including ischaemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in <1% of patients. Conclusion Considerable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare during hospitalization. [GRAPHICS] .

Published
2022

23. Global longitudinal strain by CMR improves prognostic stratification in acute myocarditis presenting with normal LVEF

Author

Porcari, A, primary, Merlo, M, additional, Baggio, C, additional, Gagno, G, additional, Andreis, A, additional, Rosmini, S, additional, Raafs, A, additional, Bromage, D, additional, Cannata', A, additional, Di Bella, G, additional, Nucifora, G, additional, Perazzolo Marra, M, additional, Heymans, S, additional, Imazio, M, additional, and Sinagra, G, additional

Published
2022
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24. C65 POST–DISCHARGE ARRHYTHMIC RISK STRATIFICATION OF PATIENTS WITH ACUTE MYOCARDITIS AND LIFE–THREATENING VENTRICULAR TACHYARRHYTHMIAS

Author

Gentile, P, primary, Merlo, M, additional, Peretto, G, additional, Ammirati, E, additional, Sala, S, additional, Della Bella, P, additional, Aquaro, G, additional, Imazio, M, additional, Potena, L, additional, Campodonico, J, additional, Foà, A, additional, Raafs, A, additional, Hazebroek, M, additional, Brambatti, M, additional, Cercek, A, additional, Nucifora, G, additional, Shrivastava, S, additional, Huang, F, additional, Schmidt, M, additional, Muser, D, additional, Van De Heyning, C, additional, Van Craenenbroeck, E, additional, Aoki, T, additional, Sugimura, K, additional, Shimokawa, H, additional, Cannatà, A, additional, Artico, J, additional, Porcari, A, additional, Colopi, M, additional, Bussani, R, additional, Barbati, G, additional, Garascia, A, additional, Cipriani, M, additional, Agostoni, P, additional, Pereira, N, additional, Heymans, S, additional, Adler, E, additional, Camici, P, additional, Frigerio, M, additional, and Sinagra, G, additional

Published
2022
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25. Safeguarding the Blue Planet – Eight Recommendations to sustainably use and govern the Ocean and its Resources

Author

Schoderer, M., Bittig, H., Gaill, F., Gjerde, K., Heymans, S., Klein, B., Obura, D., Thiele, T., Unger, S., Visbeck, M., and Hornidge, A.

Abstract

Over 30% of the world’s population lives within 100 km of the oceanic coast. More than three billion people rely on fishing and other ocean-related livelihoods. The ocean is a biodiversity hotspot and moderates the climate, having absorbed around 40% of the world’s total carbon emissions. Oceanscapes provide an essential cultural good, offer recreational opportunities, health benefits, artistic inspiration and an entire cosmology and way of life for indigenous communities. However, anthropogenic pressures have seriously impacted the ocean and threaten its ability to provide human societies with the required climatic and ecosystem conditions for life on earth. The German G7 presidency has proposed a G7 “Ocean Deal” for the sustainable use, protection and effective governance of the ocean and its resources. Several ongoing global ocean governance processes require strong multilateral leadership and close alignment between the G7, in particular in this period of serious international tensions following the Russian invasion of Ukraine. At the One Ocean Summit in February 2022, global leaders have put forth first commitments to make 2022 a decision year for the ocean. Building on the final declaration of the summit and the UK G7 Ocean Decade Navigation Plan, we highlight that a G7 “Ocean Deal” should include provisions for 1) ambitious ocean governance to safeguard ocean health and climate (in the G7’s own waters and through leadership in international settings), 2) improving ocean observation, data infrastructure and knowledge sharing, and 3) financing the transition towards more sustainable interactions with the ocean. Specifically, we recommend that G7 states: 1a. Eliminate national subsidies that contribute to overfishing and push to finalize the related WTO agreement; step up international cooperation, financial & technical assistance to prevent IUU fishing. 1b. Reduce marine debris through a comprehensive global agreement on plastic pollution. 1c. Pause deep sea mining until risks are better understood and a transparent, inclusive and accountable institutional structure is in place that guarantees the effective protection of the marine environment. 1d. Expand marine protected areas in line with the proposed goal of at least 30% by 2030, and accelerate work in the coming months to successfully finalize negotiations for a legally binding instrument to conserve and sustainably use marine biological diversity in areas beyond national jurisdiction (BBNJ). 1e. Fully recognize the importance of the ocean-climate nexus and strengthen the ocean dimension in key climate negotiations. 2a. Adopt a legal framework and binding commitments for a sustained and shared global coordination of ocean observations and infrastructure on marine data, compliant with FAIR and CARE principles. 2b. Ensure long-term, guaranteed funding, clear institutional affiliations, coordinated and integrated data products to enable continuous, comprehensive observations supporting policy monitoring & evaluation 3a. Redesign and scale up ocean finance by increasing funding of early-stage, nature-positive and science-based opportunities, and large-scale investment into zero-carbon, resilient and nature-based coastal blue infrastructure, and by integrating ocean criteria into sustainability finance frameworks (EU Taxonomy, Task Force on Climate-related Financial Disclosures (TCFD), Taskforce for Nature-related Financial Disclosures (TNFD)).

Published
2022

26. Additional file 7 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Abstract

Additional file 7. A) Univariable association of Age 60+ with in-hospital mortality in the total cohort B) Univariable association of sex and comorbidities with in-hospital mortality in patients younger than 60 years.

Published
2022
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27. Additional file 1 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Abstract

Additional file 1. Supplemental methods.

Published
2022
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28. Additional file 4 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Subjects
mental disorders
Abstract

Additional file 4. Mediation analysis with Age ��� 70 as independent predictor, multi-comorbidity (> 2 comorbidities) as mediator and in-hospital mortality as outcome.

Published
2022
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29. Additional file 3 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Subjects
body regions
Abstract

Additional file 3. Univariable, and Multivariable and Age cubic Spline adjusted association of Age, Gender, and comorbidity count with in-hospital mortality.

Published
2022
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30. Additional file 5 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Abstract

Additional file 5. Age-spline adjusted associations with predicted in-hospital mortality, stratified for: A) sex; B) number of comorbidities; C) hypertension; D) diabetes mellitus; E) dyslipidemia; F) chronic kidney disease; G) chronic obstructive pulmonary disease (COPD); H) cardiac disease.

Published
2022
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31. Additional file 2 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Abstract

Additional file 2. Clinical characteristics of males and females.

Published
2022
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32. Additional file 6 of Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study

Author

Henkens, M. T. H. M., Raafs, A. G., Verdonschot, J. A. J., Linschoten, M., van Smeden, M., Wang, P., van der Hooft, B. H. M., Tieleman, R., Janssen, M. L. F., ter Bekke, R. M. A., Hazebroek, M. R., van der Horst, I. C. C., Asselbergs, F. W., Magdelijns, F. J. H., and Heymans, S. R. B.

Abstract

Additional file 6. Clinical characteristics of patients below and ��� 60 years of age.

Published
2022
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33. Linee guida ESC 2021 per la diagnosi e il trattamento dello scompenso cardiaco acuto e cronico elaborate dalla Task Force per la diagnosi e il trattamento dello scompenso cardiaco acuto e cronico della Società Europea di Cardiologia (ESC) con il contributo straordinario della Heart Failure Association (HFA) dell’ESC = [2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC]

Author

Mcdonagh, T.A., Metra, M., Adamo, M., Gardner, R.S., Baumbach, A., Boehm, M., Burri, H., Butler, J., Celutkiene, J., Chioncel, O., Cleland, J.G.F., Coats, A.J.S., Crespo-Leiro, M.G., Farmakis, D., Gilard, M., Heymans, S., Hoes, A.W., Jaarsma, T., Jankowska, E.A., Lainscak, M., Lam, C.S.P., Lyon, A.R., Mcmurray, John, J., V, Mebazaa, A., Mindham, R., Muneretto, C., Piepoli, M.F., Price, S., Rosano, G.M.C., Ruschitzka, F., and Skibelund, A.K.

Subjects
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Published
2022

39. Phase-Change Perfluorobutane Polymerized Lipid-Shelled Nanodroplets for Ultrasound and MRI Imaging

Author

Toumia, Y, Heymans, S, Carlier, B, Saini, S, Lange, H, Dominici, F, Himmelreich, U, VAN DEN ABEELE, K, Sterpin, E, D'Hooge, J, D'Agostino, E, Paradossi, G, TOUMIA Y, HEYMANS S V, CARLIER B, SAINI S, LANGE H, DOMINICI F, HIMMELREICH U, VAN DEN ABEELE K, STERPIN E, D'HOOGE J, D'AGOSTINO E, PARADOSSI G, Toumia, Y, Heymans, S, Carlier, B, Saini, S, Lange, H, Dominici, F, Himmelreich, U, VAN DEN ABEELE, K, Sterpin, E, D'Hooge, J, D'Agostino, E, Paradossi, G, TOUMIA Y, HEYMANS S V, CARLIER B, SAINI S, LANGE H, DOMINICI F, HIMMELREICH U, VAN DEN ABEELE K, STERPIN E, D'HOOGE J, D'AGOSTINO E, and PARADOSSI G

Published
2019

40. Setting the course for a sustainable blue planet: Recommendations for enhancing EU action

Author

Dodgshun, J., Strosser, P., Alexander, B., Heymans, S., Neumann, B., Boteler, B., and Unger, S.

Abstract

The European Commission (EC) with the European External Action Service (EEAS) launched the European Union (EU) International Ocean Governance Forum (IOG Forum) in 2020. It was created as a platform for ocean stakeholders within and beyond Europe to share knowledge, experiences and good practices on ocean governance, and to support the further development of the EU’s International Ocean Governance Agenda (IOG Agenda). The online engagement of experts and stakeholders from Europe and beyond via webinars, workshops and a targeted public consultation throughout 2020 helped identify key international ocean governance actions that could be implemented by the EU to help set the course for a sustainable blue planet. Contributions obtained have been compiled by the consortium of scientific institutions and think tanks supporting the EC. Through a co-creative process with experts from the EC and the EEAS, these contributions were turned into recommendations for priority EU actions and proposed implementation pathways.

Published
2021

41. 2020 ESC Guidelines for the management of adult congenital heart disease

Author

Baumgartner, H., De Backer, J., Babu-Narayan, S. V., Budts, W., Chessa, M., Diller, G. -P., Lung, B., Kluin, J., Lang, I. M., Meijboom, F., Moons, P., Mulder, B. J. M., Oechslin, E., Roos-Hesselink, J. W., Schwerzmann, M., Sondergaard, L., Zeppenfeld, K., Ernst, S., Ladouceur, M., Aboyans, V., Alexander, D., Christodorescu, R., Corrado, D., D'Alto, M., De Groot, N., Delgado, V., Di Salvo, G., Dos Subira, L., Eicken, A., Fitzsimons, D., Frogoudaki, A. A., Gatzoulis, M., Heymans, S., Horer, J., Houyel, L., Jondeau, G., Katus, H. A., Landmesser, U., Lewis, B. S., Lyon, A., Mueller, C. E., Mylotte, D., Petersen, S. E., Sonia Petronio, A., Roffi, M., Rosenhek, R., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Torp-Pedersen, C. T., Touyz, R. M., Van De Bruaene, A., Iung, B., Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Heart Defects, Congenital, Adult, medicine.medical_specialty, Patient follow up, Heart disease, diagnosis, [SDV]Life Sciences [q-bio], Cardiology, Disease, 030204 cardiovascular system & hematology, Guidelines, adult, catheter intervention, congenital cardiac surgery, congenital heart disease, disease, imaging, late complications, medicaltreatment, patient follow-up, recommendations, Humans, 03 medical and health sciences, Congenital, 0302 clinical medicine, medicine.artery, Internal medicine, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Heart Defects, Aorta, Lung, Medical treatment, business.industry, Cardiac arrhythmia, medicine.disease, Shunt (medical), medicine.anatomical_structure, Cardiology and Cardiovascular Medicine, business
Abstract

International audience

Published
2021
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42. 2020 ESC Guidelines for the management of adult congenital heart disease: The Task Force for the management of adult congenital heart disease of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Adult Congenital Heart Disease (ISACHD)

Author

Baumgartner, H., De Backer, J., Babu-Narayan, S. V., Budts, W., Chessa, M., Diller, G. -P., Iung, B., Kluin, J., Lang, I. M., Meijboom, F., Moons, P., Mulder, B. J. M., Oechslin, E., Roos-Hesselink, J. W., Schwerzmann, M., Sondergaard, L., Zeppenfeld, K., Ernst, S., Ladouceur, M., Aboyans, V., Alexander, D., Christodorescu, R., Corrado, D., D'Alto, M., de Groot, N., Delgado, V., Di Salvo, G., Dos Subira, L., Eicken, A., Fitzsimons, D., Frogoudaki, A. A., Gatzoulis, M., Heymans, S., Horer, J., Houyel, L., Jondeau, G., Katus, H. A., Landmesser, U., Lewis, B. S., Lyon, A., Mueller, C. E., Mylotte, D., Petersen, S. E., Petronio, A. S., Roffi, M., Rosenhek, R., Shlyakhto, E., Simpson, I. A., Sousa-Uva, M., Torp-Pedersen, C. T., Touyz, R. M., and Van De Bruaene, A.

Published
2021

43. Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Author

Zacchigna, S, Paldino, A, Falcao-Pires, I, Daskalopoulos, EP, Dal Ferro, M, Vodret, S, Lesizza, P, Cannata, A, Miranda-Silva, D, Lourenco, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, CG, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, WA, Cuijpers, I, Heymans, S, Hamdani, N, Boer, Monique, Duncker, Dirk-jan, Kuster, D, Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J, Thum, T, Zacchigna, S, Paldino, A, Falcao-Pires, I, Daskalopoulos, EP, Dal Ferro, M, Vodret, S, Lesizza, P, Cannata, A, Miranda-Silva, D, Lourenco, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, CG, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, WA, Cuijpers, I, Heymans, S, Hamdani, N, Boer, Monique, Duncker, Dirk-jan, Kuster, D, Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J, and Thum, T

Abstract

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.

Published
2021

49. Phase-Change Perfluorobutane Polymerized Lipid-Shelled Nanodroplets for Ultrasound and MRI Imaging

Author

TOUMIA Y, HEYMANS S V, CARLIER B, SAINI S, LANGE H, DOMINICI F, HIMMELREICH U, VAN DEN ABEELE K, STERPIN E, D'HOOGE J, D'AGOSTINO E, PARADOSSI G, Toumia, Y, Heymans, S, Carlier, B, Saini, S, Lange, H, Dominici, F, Himmelreich, U, VAN DEN ABEELE, K, Sterpin, E, D'Hooge, J, D'Agostino, E, and Paradossi, G

Subjects
Phase-Change, polyperfluorobutane, nanodroplets, ultrasound, MRI
Published
2019

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