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Your search keyword '"Hicken EJ"' showing total 14 results

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14 results on '"Hicken EJ"'

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1. Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.

2. Identification of the Clinical Candidate PF-07284890 ( ARRY-461 ), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.

3. Discovery of Potent and Selective Covalent Inhibitors of HER2 WT and HER2 YVMA .

4. Identification of the Clinical Development Candidate MRTX849 , a Covalent KRAS G12C Inhibitor for the Treatment of Cancer.

5. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

6. Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.

8. Phase-transfer-catalyzed asymmetric acylimidazole alkylation.

9. Total synthesis of the hydroxyketone kurasoin A using asymmetric phase-transfer alkylation.

10. Asymmetric phase-transfer catalyzed glycolate alkylation, investigation of the scope, and application to the synthesis of (-)-ragaglitazar.

11. Phase-transfer-catalyzed asymmetric glycolate alkylation.

12. Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin: asymmetric glycolate aldol reactions and biological evaluation.

13. Selective synthesis of the para-quinone region of geldanamycin.

14. Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions.

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