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24 results on '"Hicks, Michael B."'

1. Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities

Author

Jurica, Elizabeth A., Wu, Ximao, Williams, Kristin N., Haque, Lauren E., Rampulla, Richard A., Mathur, Arvind, Zhou, Min, Cao, Gary, Cai, Hong, Wang, Tao, Liu, Heng, Xu, Carrie, Kunselman, Lori K., Antrilli, Thomas M., Hicks, Michael B., Sun, Qin, Dierks, Elizabeth A., Apedo, Atsu, Moore, Douglas B., Foster, Kimberly A., Cvijic, Mary Ellen, Panemangalore, Reshma, Khandelwal, Purnima, Wilkes, Jason J., Zinker, Bradley A., Robertson, Donald G., Janovitz, Evan B., Galella, Michael, Li, Yi-Xin, Li, Julia, Ramar, Thangeswaran, Jalagam, Prasada Rao, Jayaram, Ramya, Whaley, Jean M., Barrish, Joel C., Robl, Jeffrey A., Ewing, William R., and Ellsworth, Bruce A.

Published
2023
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10. Correction: Making the move towards modernized greener separations: introduction of the analytical method greenness score (AMGS) calculator

Author

Hicks, Michael B., primary, Farrell, William, additional, Aurigemma, Christine, additional, Lehmann, Laurent, additional, Weisel, Lauren, additional, Nadeau, Kelly, additional, Lee, Heewon, additional, Moraff, Carol, additional, Wong, Mengling, additional, Huang, Yun, additional, and Ferguson, Paul, additional

Published
2020
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15. Current challenges and future prospects in chromatographic method development for pharmaceutical research

Author

Mattrey, Frederick T., primary, Makarov, Alexey A., additional, Regalado, Erik L., additional, Bernardoni, Frank, additional, Figus, Margaret, additional, Hicks, Michael B., additional, Zheng, Jinjian, additional, Wang, Lin, additional, Schafer, Wes, additional, Antonucci, Vincent, additional, Hamilton, Simon E., additional, Zawatzky, Kerstin, additional, and Welch, Christopher J., additional

Published
2017
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16. Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode

Author

Jurica, Elizabeth A., primary, Wu, Ximao, additional, Williams, Kristin N., additional, Hernandez, Andres S., additional, Nirschl, David S., additional, Rampulla, Richard A., additional, Mathur, Arvind, additional, Zhou, Min, additional, Cao, Gary, additional, Xie, Chunshan, additional, Jacob, Biji, additional, Cai, Hong, additional, Wang, Tao, additional, Murphy, Brian J., additional, Liu, Heng, additional, Xu, Carrie, additional, Kunselman, Lori K., additional, Hicks, Michael B., additional, Sun, Qin, additional, Schnur, Dora M., additional, Sitkoff, Doree F., additional, Dierks, Elizabeth A., additional, Apedo, Atsu, additional, Moore, Douglas B., additional, Foster, Kimberly A., additional, Cvijic, Mary Ellen, additional, Panemangalore, Reshma, additional, Flynn, Neil A., additional, Maxwell, Brad D., additional, Hong, Yang, additional, Tian, Yuan, additional, Wilkes, Jason J., additional, Zinker, Bradley A., additional, Whaley, Jean M., additional, Barrish, Joel C., additional, Robl, Jeffrey A., additional, Ewing, William R., additional, and Ellsworth, Bruce A., additional

Published
2017
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22. <TOGGLE>In Situ</TOGGLE> moisture determination of a cytotoxic compound during process optimization

Author

Hicks, Michael B., Zhou, George X., Lieberman, David R., Antonucci, Vincent, Ge, Zhihong, Shi, Yao-Jun, Cameron, Mark, and Lynch, Joseph E.

Abstract

A simple and safe prototype apparatus was designed and adapted for the in situ determination of the moisture content of a cytotoxic compound (9-fluorenylmethyl-protected doxorubicin-peptide conjugate, or Fm-DPC) by near-infrared absorbance spectroscopy during optimization of the chemical isolation procedure. The cytotoxic nature of the compound restricts one's ability to safely sample such drying processes for more traditional means of moisture determination for fear of hazardous solids dusting, hence in situ sampling approaches are of great importance. These concerns also exist for the process development laboratory, where despite the smaller scale of operations, the volume of experiments (hence cytotoxic samples) required to define a chemical process is often more significant. In this application, partial least squares regression was used with Karl Fischer volumetric titration analysis to generate a calibration model. Although pronounced differences in cake density were observed as a function of the buffer selected for the isolation process, the model still achieved a standard error of calibration of 0.63% w/w and a standard error of prediction of 0.99% (w/w). These results demonstrated the versatility of the prototype apparatus/data processing approach to model Fm-DPC drying under extremely variable conditions, as inherently expected during the investigational laboratory development of a chemical process. © 2003 Wiley-Liss Inc. and the American Pharmaeceutical Association J Pharm Sci 92:529–535, 2003

Published
2003
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23. In SituMoisture Determination of a Cytotoxic Compound During Process Optimization

Author

Hicks, Michael B., Zhou, George X., Lieberman, David R., Antonucci, Vincent, Ge, Zhihong, Shi, Yao‐Jun, Cameron, Mark, and Lynch, Joseph E.

Abstract

A simple and safe prototype apparatus was designed and adapted for the in situdetermination of the moisture content of a cytotoxic compound (9‐fluorenylmethyl‐protected doxorubicin‐peptide conjugate, or Fm‐DPC) by near‐infrared absorbance spectroscopy during optimization of the chemical isolation procedure. The cytotoxic nature of the compound restricts one's ability to safely sample such drying processes for more traditional means of moisture determination for fear of hazardous solids dusting, hence in situsampling approaches are of great importance. These concerns also exist for the process development laboratory, where despite the smaller scale of operations, the volume of experiments (hence cytotoxic samples) required to define a chemical process is often more significant. In this application, partial least squares regression was used with Karl Fischer volumetric titration analysis to generate a calibration model. Although pronounced differences in cake density were observed as a function of the buffer selected for the isolation process, the model still achieved a standard error of calibration of 0.63% w/w and a standard error of prediction of 0.99% (w/w). These results demonstrated the versatility of the prototype apparatus/data processing approach to model Fm‐DPC drying under extremely variable conditions, as inherently expected during the investigational laboratory development of a chemical process.

Published
2003
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24. In situ moisture determination of a cytotoxic compound during process optimization.

Author

Hicks MB, Zhou GX, Lieberman DR, Antonucci V, Ge Z, Shi YJ, Cameron M, and Lynch JE

Subjects
Doxorubicin toxicity, Pharmaceutical Preparations analysis, Pharmaceutical Preparations chemistry, Spectroscopy, Near-Infrared instrumentation, Spectroscopy, Near-Infrared methods, Technology, Pharmaceutical instrumentation, Water analysis, Water chemistry, Doxorubicin analysis, Doxorubicin chemistry, Technology, Pharmaceutical methods
Abstract

A simple and safe prototype apparatus was designed and adapted for the in situ determination of the moisture content of a cytotoxic compound (9-fluorenylmethyl-protected doxorubicin-peptide conjugate, or Fm-DPC) by near-infrared absorbance spectroscopy during optimization of the chemical isolation procedure. The cytotoxic nature of the compound restricts one's ability to safely sample such drying processes for more traditional means of moisture determination for fear of hazardous solids dusting, hence in situ sampling approaches are of great importance. These concerns also exist for the process development laboratory, where despite the smaller scale of operations, the volume of experiments (hence cytotoxic samples) required to define a chemical process is often more significant. In this application, partial least squares regression was used with Karl Fischer volumetric titration analysis to generate a calibration model. Although pronounced differences in cake density were observed as a function of the buffer selected for the isolation process, the model still achieved a standard error of calibration of 0.63% w/w and a standard error of prediction of 0.99% (w/w). These results demonstrated the versatility of the prototype apparatus/data processing approach to model Fm-DPC drying under extremely variable conditions, as inherently expected during the investigational laboratory development of a chemical process., (Copyright 2003 Wiley-Liss Inc. and the American Pharmaeceutical Association)

Published
2003
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