1,519 results on '"Hideo Tanaka"'
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2. Deep UV-excited fluorescence microscopy installed with CycleGAN-assisted image translation enhances precise detection of lymph node metastasis towards rapid intraoperative diagnosis
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Junya Sato, Tatsuya Matsumoto, Ryuta Nakao, Hideo Tanaka, Hajime Nagahara, Hirohiko Niioka, and Tetsuro Takamatsu
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Medicine ,Science - Abstract
Abstract Rapid and precise intraoperative diagnosing systems are required for improving surgical outcomes and patient prognosis. Because of the poor quality and time-intensive process of the prevalent frozen section procedure, various intraoperative diagnostic imaging systems have been explored. Microscopy with ultraviolet surface excitation (MUSE) is an inexpensive, maintenance-free, and rapid imaging technique that yields images like thin-sectioned samples without sectioning. However, pathologists find it nearly impossible to assign diagnostic labels to MUSE images of unfixed specimens; thus, AI for intraoperative diagnosis cannot be trained in a supervised learning manner. In this study, we propose a deep-learning pipeline model for lymph node metastasis detection, in which CycleGAN translate MUSE images of unfixed lymph nodes to formalin-fixed paraffin-embedded (FFPE) sample, and diagnostic prediction is performed using deep convolutional neural network trained on FFPE sample images. Our pipeline yielded an average accuracy of 84.6% when using each of the three deep convolutional neural networks, which is a 18.3% increase over the classification-only model without CycleGAN. The modality translation to FFPE sample images using CycleGAN can be applied to various intraoperative diagnostic imaging systems and eliminate the difficulty for pathologists in labeling new modality images in clinical sites. We anticipate our pipeline to be a starting point for accurate rapid intraoperative diagnostic systems for new imaging modalities, leading to healthcare quality improvement.
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- 2023
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3. Smoking cessation behavior in patients with a diagnosis of a non-communicable disease: The impact of perceived disease severity of and susceptibility to the disease
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Chie Taniguchi, Akihiko Narisada, Hirohiko Ando, Akane Hashimoto, Ayako Nakayama, Masaki Ito, Hideo Tanaka, and Kohta Suzuki
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smoking cessation ,non-communicable diseases ,health belief model ,perceived susceptibility ,perceived severity ,Diseases of the respiratory system ,RC705-779 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction The Health Belief Model comprises two constructs influencing changed behaviors impacting on health, namely perceived severity and susceptibility. The aim of this study was to identify the impact of the combination of, or interactions between, these two constructs on quitting smoking in smokers with a diagnosis of a non-communicable disease (NCD). Methods From the large insurance claims database maintained by JMDC database (JMDC, Tokyo), we extracted data on 13284 participants who smoked. All participants were stratified according to their NCD diagnosis based on perceived severity and susceptibility as follows: Category I (high severity and high susceptibility) – acute myocardial infarction, and lung cancer; Category II (high severity and low susceptibility) – colorectal cancer, and stomach cancer; Category III (low severity and high susceptibility) – asthma, and transient ischemic attack; Category IV (low severity and low susceptibility) – appendicitis, and glaucoma. We performed multi-variable logistic regression analysis and calculated the proportion of those who were smoking at the first health check-up after the diagnosis and every three years thereafter. Results Using glaucoma as the reference, the adjusted odds ratios for smoking cessation were 14.2 (95% CI: 11.4–17.8) to 14.8 (95% CI: 12.5–17.4) in Category I; 4.5 (95% CI: 3.8–5.4) to 6.6 (95% CI: 5.4–8.0) in Category II; and 1.9 (95% CI: 1.7–2.1) to 2.8 (95% CI: 2.2–3.7) in Category III. In Categories I and II, the proportion of smokers rapidly decreased after diagnosis and mostly remained low thereafter. Smoking cessation rates for Categories I and II were not associated with readiness to improve lifestyles prior to NCD diagnosis. Conclusions Our study confirms the significant impact of perceived severity of and susceptibility to the diagnosed disease on smoking cessation. The multiplicative effect of these two constructs at NCD diagnosis represents a ‘teachable moment’, a window of opportunity, for encouraging successful long-term smoking cessation.
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- 2023
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4. Myofibroblasts impair myocardial impulse propagation by heterocellular connexin43 gap-junctional coupling through micropores
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Yumika Tsuji, Takehiro Ogata, Kentaro Mochizuki, Shoko Tamura, Yuma Morishita, Tetsuro Takamatsu, Satoaki Matoba, and Hideo Tanaka
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myofibroblast ,cardiomyocyte ,optical mapping ,impulse propagation ,electrotonic effect ,connexin 43 ,Physiology ,QP1-981 - Abstract
Aim: Composite population of myofibroblasts (MFs) within myocardial tissue is known to alter impulse propagation, leading to arrhythmias. However, it remains unclear whether and how MFs alter their propagation patterns when contacting cardiomyocytes (CMs) without complex structural insertions in the myocardium. We attempted to unveil the effects of the one-sided, heterocellular CM-MF connection on the impulse propagation of CM monolayers without the spatial insertion of MFs as an electrical or mechanical obstacle.Methods and results: We evaluated fluo8-based spatiotemporal patterns in impulse propagation of neonatal rat CM monolayers cultured on the microporous membrane having 8-μm diameter pores with co-culture of MFs or CMs on the reverse membrane side (CM-MF model or CM-CM model, respectively). During consecutive pacing at 1 or 2 Hz, the CM monolayers exhibited forward impulse propagation from the pacing site with a slower conduction velocity (θ) and a larger coefficient of directional θ variation in the CM-MF model than that in the CM-CM model in a frequency-dependent manner (2 Hz >1 Hz). The localized placement of an MF cluster on the reverse side resulted in an abrupt segmental depression of the impulse propagation of the upper CM layer, causing a spatiotemporally non-uniform pattern. Dye transfer of the calcein loaded in the upper CM layer to the lower MF layer was attenuated by the gap-junction inhibitor heptanol. Immunocytochemistry identified definitive connexin 43 (Cx43) between the CMs and MFs in the membrane pores. MF-selective Cx43 knockdown in the MF layer improved both the velocity and uniformity of propagation in the CM monolayer.Conclusion: Heterocellular Cx43 gap junction coupling of CMs with MFs alters the spatiotemporal patterns of myocardial impulse propagation, even in the absence of spatially interjacent and mechanosensitive modulations by MFs. Moreover, MFs can promote pro-arrhythmogenic impulse propagation when in face-to-face contact with the myocardium that arises in the healing infarct border zone.
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- 2024
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5. SARS-CoV-2 Incubation Period during the Omicron BA.5–Dominant Period in Japan
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Tsuyoshi Ogata and Hideo Tanaka
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COVID-19 ,Omicron ,BA.5 ,respiratory infections ,severe acute respiratory syndrome coronavirus 2 ,SARS-CoV-2 ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
The mean virus incubation period during the SARS-CoV-2 Omicron BA.5–dominant period in Japan was 2.6 (95% CI 2.5–2.8) days, which was less than during the Delta-dominant period. Incubation period correlated with shared meals and adult infectors. A shorter incubation suggests a shorter quarantine period for BA.5 than for other variants.
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- 2023
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6. Generation of myocyte agonal Ca2+ waves and contraction bands in perfused rat hearts following irreversible membrane permeabilisation
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Yuma Morishita, Shoko Tamura, Kentaro Mochizuki, Yoshinori Harada, Tetsuro Takamatsu, Hajime Hosoi, and Hideo Tanaka
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Medicine ,Science - Abstract
Abstract Although irreversible cardiomyocyte injury provokes intracellular Ca2+ ([Ca2+]i) overload, the underlying dynamics of this response and its effects on cellular morphology remain unknown. We therefore visualised rapid-scanning confocal fluo4-[Ca2+]i dynamics and morphology of cardiomyocytes in Langendorff-perfused rat hearts following saponin-membrane permeabilisation. Our data demonstrate that 0.4% saponin-treated myocytes immediately exhibited high-frequency Ca2+ waves (131.3 waves/min/cell) with asynchronous, oscillatory contractions having a mean propagation velocity of 117.8 μm/s. These waves slowly decreased in frequency, developed a prolonged decay phase, and disappeared in 10 min resulting in high-static, fluo4-fluorescence intensity. The myocytes showing these waves displayed contraction bands, i.e., band-like actin-fibre aggregates with disruption of sarcomeric α-actinin. The contraction bands were not attenuated by the abolition of Ca2+ waves under pretreatment with ryanodine plus thapsigargin, but were partially attenuated by the calpain inhibitor MDL28170, while mechanical arrest of the myocytes by 2,3-butanedione monoxime completely attenuated contraction-band formation. The depletion of adenosine 5′-triphosphate by the mitochondrial electron uncoupler carbonyl cyanide 4-trifluoromethoxy phenylhydrazone also attenuated Ca2+ waves and contraction bands. Overall, saponin-induced myocyte [Ca2+]i overload provokes agonal Ca2+ waves and contraction bands. Contraction bands are not the direct consequence of the waves but are caused by cross-bridge interactions of the myocytes under calpain-mediated proteolysis.
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- 2023
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7. The impact of treatment on the psychological burden of mothers of children with chronic hepatitis C virus infection: a multicenter, questionnaire survey
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Tomoya Fukuoka, Kazuhiko Bessho, Satoyo Hosono, Daiki Abukawa, Tatsuki Mizuochi, Koichi Ito, Jun Murakami, Hideo Tanaka, Yoko Miyoshi, Tomoko Takano, and Hitoshi Tajiri
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Medicine ,Science - Abstract
Abstract Mothers of children with chronic hepatitis C virus (HCV) infection experience anxiety about the health of their children. In this study we assessed an impact of treating children with chronic HCV infection on the psychological burden of their mothers. This was a multicenter, questionnaire survey conducted at six institutions in Japan. A newly-developed questionnaire for this study was used to assess changes in the mothers’ various concerns regarding HCV infection and thoughts about their child’s HCV infection. Responses at the time of diagnosis and at the time of the survey were compared between mothers of children who had received treatment and those without treatment. Responses were received from 36 of 37 eligible mothers (11 and 25, non-treatment and treatment groups, respectively). All children in treatment group had successfully eliminated the virus. Mothers in both groups were psychologically stressed in various ways, including concern about their child’s health in the present and future at the time of diagnosis, concern about school, employment, and marriage, concern about the behavior of others towards them and infecting others with HCV, and feelings of guilt regarding their child. These concerns were significantly lower in the present compared to at the time of diagnosis in treatment group, and the rate of decrease was significantly higher in treatment group compared to non-treatment group. Successful treatment greatly reduced mothers’ concerns about their children’s HCV infection, indicating that treatment during childhood is beneficial from the perspective of the mothers’ psychological burden.
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- 2022
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8. SARS-CoV-2 Incubation Period during Omicron BA.5–Dominant Period, Japan (Response)
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Tsuyoshi Ogata and Hideo Tanaka
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COVID-19 ,respiratory infections ,severe acute respiratory syndrome coronavirus 2 ,SARS-CoV-2 ,SARS ,incubation period ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Published
- 2024
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9. P654: ALLELIC POLYMORPHISMS OF KIRS AND HLAS PREDICT FAVORABLE ACHIEVEMENT OF TREATMENT-FREE REMISSION IN CML: RESULTS FROM THE POKSTIC TRIAL, MULTICENTER RETROSPECTIVE OBSERVATIONAL STUDY
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Hiroshi Ureshino, Yasunori Ueda, Shin Fujisawa, Kensuke Usuki, Hideo Tanaka, Masaya Okada, Shugo Kowata, Kazunori Murai, Asao Hirose, Motohiro Shindo, Takashi Kumagai, Takafumi Nakao, Tomoharu Takeoka, Kazuharu Kamachi, Keisuke Kidoguchi, Satoshi Iyama, Junki Inamura, Tsutomu Kobayashi, Eri Kawata, Hiroshi Ohkawara, Takayuki Ikezoe, and Shinya Kimura
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2023
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10. Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study
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Kenji Takeuchi, Mariko Naito, Sayo Kawai, Mineko Tsukamoto, Yuka Kadomatsu, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Masahiro Nakatochi, Tae Sasakabe, Shuji Hashimoto, Hidetaka Eguchi, Yukihide Momozawa, Hiroaki Ikezaki, Masayuki Murata, Norihiro Furusyo, Keitaro Tanaka, Megumi Hara, Yuichiro Nishida, Keitaro Matsuo, Hidemi Ito, Isao Oze, Haruo Mikami, Yohko Nakamura, Miho Kusakabe, Toshiro Takezaki, Rie Ibusuki, Ippei Shimoshikiryo, Sadao Suzuki, Takeshi Nishiyama, Miki Watanabe, Teruhide Koyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Yoshikuni Kita, Hirotsugu Ueshima, Kenji Matsui, Kokichi Arisawa, Hirokazu Uemura, Sakurako Katsuura-Kamano, Sho Nakamura, Hiroto Narimatsu, Nobuyuki Hamajima, Hideo Tanaka, and Kenji Wakai
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study profile ,cohort study ,gene–environment interactions ,cancer ,j-micc ,Medicine (General) ,R5-920 - Abstract
Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. Methods: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples. Results: The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. Conclusions: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.
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- 2021
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11. Eosinophilic Cholangitis with Poor Prognosis after Corticosteroid- and Ursodeoxycholic Acid-Related Remission of Peripheral and Peribiliary Eosinophilia
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Takahito Shimomura, Tomoki Nakajima, Toshiaki Nakashima, Yasutaka Morimoto, Junko Yamaoka, Akiko Shibuya, Tomoyuki Ohno, Norimasa Yoshida, Mitsuo Kishimoto, Eiichi Konishi, Hideo Tanaka, Michihisa Moriguchi, and Yoshito Itoh
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eosinophilic cholangitis ,sclerosing cholangitis ,eosinophilic cholecystitis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
A 79-year-old man presented with high fever, marked eosinophilia, altered biochemical liver function tests (LFT) with predominance of biliary enzymes, and severe wall thickening of the gallbladder. Magnetic resonance cholangiopancreatography (MRCP) suggested cholecystitis, without signs of biliary strictures. Laparoscopic cholecystectomy and exploratory liver excision revealed eosinophilic cholangitis and cholecystitis, complicated with hepatitis and portal phlebitis. Prednisolone monotherapy rapidly improved peripheral eosinophilia, but not LFT. Liver biopsy showed that infiltrating eosinophils were replaced by lymphocytes and plasma cells. Treatment with ursodeoxycholic acid improved LFT abnormalities. Nevertheless, after 2 months, transaminase-dominant LFT abnormalities appeared. Transient prednisolone dose increase improved LFT, but biliary enzymes’ levels re-elevated and jaundice progressed. The second and third MRCP within a 7-month interval showed rapid progression of biliary stricture. The repeated liver biopsy showed lymphocytic, not eosinophilic, peribiliary infiltration and hepatocellular reaction to cholestasis. Eighteen months after the first visit, the patient died of hepatic failure. Autopsy specimen of the liver showed lymphocyte-dominant peribiliary infiltration and bridging fibrosis due to cholestasis. Though eosinophil-induced biliary damage was an initial trigger, repeated biopsy suggested that lymphocytes played a key role in progression of the disease. Further studies are needed to elucidate the relationship between eosinophils and lymphocytes in eosinophilic cholangitis.
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- 2021
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12. Smoking cessation after cancer diagnosis reduces the risk of severe cancer pain: A longitudinal cohort study.
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Chie Taniguchi, Akihiko Narisada, Hideo Tanaka, Hiroki Iida, Mami Iida, Rina Mori, Ayako Nakayama, and Kohta Suzuki
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Medicine ,Science - Abstract
BackgroundWhether abstinence from smoking among cancer patients reduces cancer pain is still unclear. Opioids can act as a surrogate index for evaluating the incidence of severe cancer pain in countries where opioid abuse is infrequent. This study aimed to investigate whether changed smoking behavior after cancer diagnosis influences the incidence of severe cancer pain as determined by strong opioid use.MethodsUsing a large Japanese insurance claims database (n = 4,797,329), we selected 794,702 insured employees whose annual health checkup data could be confirmed ≥6 times between January 2009 and December 2018. We selected 591 study subjects from 3,256 employees who were diagnosed with cancer pain and had health checkup data at the year of cancer pain diagnosis.ResultsA significantly greater proportion of patients who continued smoking after cancer diagnosis ("current smoker", n = 133) received strong opioids (36.8%) compared with patients who had never smoked or had stopped before cancer diagnosis ("non-smoker", n = 383, 20.6%; pConclusionOur study demonstrated that patients who quit smoking after cancer diagnosis have a lower risk of severe cancer pain. This information adds clinical incentives for improving quality of life among those who smoked at the time of cancer diagnosis.
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- 2022
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13. Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid
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Midori Morita, Hideo Tanaka, Yasuaki Kumamoto, Akihiro Nakamura, Yoshinori Harada, Takehiro Ogata, Koichi Sakaguchi, Tetsuya Taguchi, and Tetsuro Takamatsu
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5‐aminolevulinic acid ,ATP‐binding cassette transporter G2 ,breast cancer ,fine needle aspiration cytology ,photodynamic diagnosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Protoporphyrin IX‐fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5‐aminolevulinic acid. However, this approach has not been clinically established for breast cancer, probably due to insufficient delivery of 5‐aminolevulinic acid to the mammary glands. In the present study, we directly exposed breast cancer cells to 5‐aminolevulinic acid to assess their discrimination via protoporphyrin IX‐fluorescence. Fluorescence intensity (FI) was measured in the human breast cancer cell lines MCF7 and MDA‐MB‐231 and breast epithelial cell line MCF10A by confocal microscopy and flow cytometry. After 5‐aminolevulinic acid exposure for 2 hours, protoporphyrin IX‐FI in MCF7 and MDA‐MB‐231 cells significantly increased with marked cell‐to‐cell variability, whereas that in MCF10A cells increased moderately. Combined exposure of the cancer cells to 5‐aminolevulinic acid and Ko143, a specific inhibitor of ATP‐binding cassette transporter G2, further increased protoporphyrin IX‐FI and alleviated the cell‐to‐cell variability in MCF7 and MDA‐MB‐231 cells, indicating improvement in the reproducibility and accuracy for fluorescence‐based cancer detection. The increased FI by combined administration of these two drugs was also demonstrated in cells obtained via fine needle aspiration from mouse xenograft models inoculated with MDA‐MB‐231 cells. Furthermore, a cutoff value for increased protoporphyrin IX‐FI ratio, before and after exposure to these drugs, clearly discriminated between cancer and noncancer cells. Taken together, direct exposure to 5‐aminolevulinic acid and Ko143 may be a promising strategy for efficient fluorescence‐based detection of breast cancer cells ex vivo using fine needle aspiration.
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- 2019
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14. 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges
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Yoshinori Harada, Yasutoshi Murayama, Tetsuro Takamatsu, Eigo Otsuji, and Hideo Tanaka
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5-aminolevulinic acid ,protoporphyrin IX ,tumor ,photodynamic diagnosis ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and chlorophyll. Exogenously administered 5-ALA is metabolized into protoporphyrin IX (PpIX). PpIX accumulates in cancer cells because of the low activity of ferrochelatase, an enzyme that metabolizes PpIX to heme. High expression of 5-ALA influx transporters, such as peptide transporters 1/2, in cancer cells also enhances PpIX production. Because PpIX radiates red fluorescence when excited with blue/violet light, 5-ALA has been used for the visualization of various tumors. 5-ALA photodynamic diagnosis (PDD) has been shown to improve the tumor removal rate in high-grade gliomas and non-muscular invasive bladder cancers. However, 5-ALA PDD remains a challenge as a diagnostic method because tissue autofluorescence interferes with PpIX signals in cases where tumors emit only weak signals, and non-tumorous lesions, such as inflammatory sites, tend to emit PpIX fluorescence. Here, we review the current outline of 5-ALA PDD and strategies for improving its diagnostic applicability for tumor detection, focusing on optical techniques and 5-ALA metabolic pathways in both viable and necrotic tumor tissues.
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- 2022
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15. Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
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Leonardo Puppulin, Shigekuni Hosogi, Hongxin Sun, Kazuhiko Matsuo, Toshio Inui, Yasuaki Kumamoto, Toshinobu Suzaki, Hideo Tanaka, and Yoshinori Marunaka
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Science - Abstract
Understanding the pH changes at cell surfaces is important for understanding the mechanisms of different physiological processes. Here, the authors report on the development of a cell membrane anchored gold nanoparticle for surface enhanced Raman spectroscopy determination of pH.
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- 2018
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16. Recent Improvement in the Long-term Survival of Breast Cancer Patients by Age and Stage in Japan
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Akiyo Yoshimura, Hidemi Ito, Yoshikazu Nishino, Masakazu Hattori, Tomohiro Matsuda, Isao Miyashiro, Tomio Nakayama, Hiroji Iwata, Keitaro Matsuo, Hideo Tanaka, and Yuri Ito
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breast cancer ,relative survival ,cancer registration ,period analysis ,long-term survival ,Medicine (General) ,R5-920 - Abstract
Background: Recent improvements in 5-year survival of breast cancer have been reported in Japan and other countries. Though the number of long-term breast cancer survivors has been increasing, recent improvements in 10-year survival have not been reported. Moreover, the degree of improvement according to age and disease stage remains unclear. Methods: We calculated long-term survival using data on breast cancer diagnosed from 1993 through 2006 from six prefectural population-based cancer registries in Japan. The recent increase in 10-year relative survival was assessed by comparing the results of period analysis in 2002–2006 with the results of cohort analysis in 1993–1997. We also conducted stratified analyses by age group (15–34, 35–49, 50–69, and 70–99 years) and disease stage (localized, regional, and distant). Results: A total of 63,348 patients were analysed. Ten-year relative survival improved by 2.4% (76.9% vs 79.3%) from 1993 through 2006. By age and stage, 10-year relative survival clearly improved in the age 35–49 years (+2.9%; 78.1% vs 81.0%), 50–69 years (+2.8%; 75.2% vs 78.0%) and regional disease (+3.4%; 64.9% vs 68.3%). In contrast, the degree of improvement was small in the age 15–34 years (+0.1%; 68.2% vs 68.3%), 70–99 years (+1.0%; 87.6% vs 88.6%), localized disease (+1.1%; 92.6% vs 93.7%) and distant metastasis (+0.9%; 13.8% vs 14.7%). Conclusions: These population-based cancer registry data show that 10-year relative survival improved 2.4% over this period in Japan. By age and stage, improvement in the age 15–34 years and distant metastasis was very small, which suggests the need for new therapeutic strategies in these patients.
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- 2018
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17. Relationship between the strength of craving as assessed by the Tobacco Craving Index and success of quitting smoking in Japanese smoking cessation therapy.
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Chie Taniguchi, Hideo Saka, Isao Oze, Sumie Nakamura, Yasuhiro Nozaki, and Hideo Tanaka
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Medicine ,Science - Abstract
BackgroundWe previously developed the Tobacco Craving Index (TCI) to assess craving of smokers. In the present study, we validated the relationship between the TCI grade over the 5 sessions of Japanese smoking cessation therapy (SCT) and success of quitting smoking among 889 Japanese patients.MethodsThe Japanese SCT consists of 5 sessions of SCT (first session and sessions 2, 4, 8 and 12 weeks later). In the TCI questionnaire, patients are asked to rate their strength of craving and frequency of craving, each on a four-point Likert scale. Patients are classified into one of four grades based on their responses (0, I, II, III, with III indicating severe craving). The TCI questionnaire was administered to each participant at each session of the SCT. This study included participants of Japanese SCT who answered the TCI at the first session of the SCT at five Japanese smoking cessation clinics. Patients who dropped out of the SCT from the second to the fifth sessions were considered to have failed smoking cessation. To elucidate how much the TCI grade predicts smoking status at the last session, we performed multivariate logistic regression analysis with adjustment for confounding factors.ResultsParticipants who had higher TCI grade(III) in the 2nd through 5th sessions showed significantly lower probability for success of quitting smoking than those who had lower TCI grades(0 or I) (adjusted odds ratio: 2nd session: 0.30, 3rd session: 0.15, 4th session: 0.06, 5th session: 0.02).ConclusionsWe validated the usefulness of the TCI grade for assessing probability of quitting smoking by using a large number of smoking cessation settings.
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- 2020
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18. Development of a new craving index for anticipating quitting smoking in patients who undergo the Japanese smoking cessation therapy
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Chie Taniguchi, Hideo Tanaka, Sumie Nakamura, Sachiyo Saito, and Hideo Saka
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craving ,tci ,qsu-brief ,quit smoking ,Diseases of the respiratory system ,RC705-779 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction The 10-item version of the Questionnaire of Smoking Urges (QSUbrief) has demonstrated excellent reliability. However, the QSU-brief may be too long to use in clinical settings. We developed a new craving index called the Tobacco Craving Index (TCI) and investigated how closely the TCI grade is associated with success of quitting smoking in Japanese smoking cessation therapy (SCT) patients. Methods The TCI questionnaire consists of two items: the first question asks about the strength of tobacco craving on a 4-point scale, and the second question asks about the frequency of tobacco craving per day on a 4-point scale. We conducted a prospective cohort study of 85 participants who underwent the Japanese SCT at a Japanese smoking cessation clinic. We administered the QSU-brief and TCI at each of the 5 sessions during the 12-week SCT. Results Significant correlations were observed between the TCI grade and QSUbrief score (r=0.27, 0.55, 0.72, 0.58 and 0.68, at the five sessions). The change in mean TCI grade showed a similar trend as the change in mean QSU-brief score among the 43 patients who succeeded in quitting smoking and also among the 7 patients who failed to quit smoking by the last session. Both TCI and QSU-brief assessed after the second session were significantly associated with the smoking status at the last session. The area under the receiver operating characteristic curve for the success of quitting smoking in TCI grade was 0.615–0.881 at the 5 sessions, whereas it was 0.536–0.849 in QSU-brief score. Conclusions The TCI can be used as a predictive tool for success of quitting smoking in the Japanese SCT. As the TCI consists of two questionnaire items, it can be easily administered in smoking cessation interventions.
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- 2019
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19. Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men
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Tae Sasakabe, Kenji Wakai, Sayo Kawai, Asahi Hishida, Mariko Naito, Sadao Suzuki, Yora Nindita, Kokichi Arisawa, Yoshikuni Kita, Megumi Hara, Nagato Kuriyama, Akie Hirata, Haruo Mikami, Isao Oze, Michiaki Kubo, Hideo Tanaka, and Nobuyuki Hamajima
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ALDH2 ,ADH1B ,alcohol intake ,lipid profile ,Medicine (General) ,R5-920 - Abstract
Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.
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- 2018
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20. Improvement in 5-Year Relative Survival in Cancer of the Corpus Uteri From 1993–2000 to 2001–2006 in Japan
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Shusaku Inoue, Satoyo Hosono, Hidemi Ito, Isao Oze, Yoshikazu Nishino, Masakazu Hattori, Tomohiro Matsuda, Isao Miyashiro, Tomio Nakayama, Mika Mizuno, Keitaro Matsuo, Kiyoko Kato, Hideo Tanaka, Yuri Ito, and the J-CANSIS Research Group
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cancer registry ,cancer of the corpus uteri ,population-based study ,prognosis ,relative survival ,Medicine (General) ,R5-920 - Abstract
Background: Medical circumstances in Japanese patients with cancer of the corpus uteri have greatly changed since the late 1990s, including the introduction of concomitant therapy with taxane and platinum. We evaluated changes in survival rates for this cancer following these advances by analyzing data from population-based cancer registries in Japan. Methods: Data were available for 8562 cases of cancer of the corpus uteri from six prefectural cancer registries. We defined the two periods of 1993–2000 (1st period) and 2001–2006 (2nd period). Relative survival (RS) in each period was calculated to assess changes using an excess mortality model, with adjustment for age group (15–54, 55–69, and 70–99 years), extent of disease (localized, regional, and distant), and histological subtype. Results: Overall 5-year RS improved from 77.7% in the 1st period to 80.2% in the 2nd period, with an excess hazard ratio (EHR) of 0.785 (95% confidence interval [CI], 0.705–0.873). Five-year RS significantly improved in the group aged 55–69 years, in all groups by extent of disease, and in the endometrioid adenocarcinoma group. In particular, 5-year RS significantly improved in patients with endometrioid adenocarcinoma, from 84.5% to 89.7%, with an EHR of 0.698 (95% CI, 0.560–0.870). Conclusion: Overall 5-year RS for cancer of the corpus uteri in Japan improved from the 1990s to early 2000s. These improvements might have been aided by the comprehensive medical development of management for this cancer, including the spread of concomitant therapy with taxane and platinum as a standard adjuvant chemotherapy in the early 2000s.
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- 2018
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21. Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
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Mariko Sasaki, Sei Harada, Yumiko Kawasaki, Miki Watanabe, Hidemi Ito, Hideo Tanaka, Ayano Takeuchi, Kazuo Tsubota, Toru Takebayashi, Yuji Nishiwaki, and Ryo Kawasaki
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Medicine ,Science - Abstract
Abstract The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex.
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- 2018
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22. Accumulation of Uroporphyrin I in Necrotic Tissues of Squamous Cell Carcinoma after Administration of 5-Aminolevulinic Acid
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Masatomo Beika, Yoshinori Harada, Takeo Minamikawa, Yoshihisa Yamaoka, Noriaki Koizumi, Yasutoshi Murayama, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji, Tetsuro Takamatsu, and Hideo Tanaka
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5-aminolevulinic acid ,uroporphyrin I ,protoporphyrin IX ,tumor necrosis ,squamous cell carcinoma ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is widely used for the intraoperative detection of malignant tumors. However, the fluorescence emission profiles of the accompanying necrotic regions of these tumors have yet to be determined. To address this, we performed fluorescence and high-performance liquid chromatography (HPLC) analyses of necrotic tissues of squamous cancer after 5-ALA administration. In resected human lymph nodes of metastatic squamous cell carcinoma, we found a fluorescence peak at approximately 620 nm in necrotic lesions, which was distinct from the PpIX fluorescence peak at 635 nm for viable cancer lesions. Necrotic lesions obtained from a subcutaneous xenograft model of human B88 oral squamous cancer also emitted the characteristic fluorescence peak at 620 nm after light irradiation: the fluorescence intensity ratio (620 nm/635 nm) increased with the energy of the irradiation light. HPLC analysis revealed a high content ratio of uroporphyrin I (UPI)/total porphyrins in the necrotic cores of murine tumors, indicating that UPI is responsible for the 620 nm peak. UPI accumulation in necrotic tissues after 5-ALA administration was possibly due to the failure of the heme biosynthetic pathway. Taken together, fluorescence imaging of UPI after 5-ALA administration may be applicable for the evaluation of tumor necrosis.
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- 2021
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23. Raman micro-spectroscopy as a viable tool to monitor and estimate the ionic transport in epithelial cells
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Leonardo Puppulin, Giuseppe Pezzotti, Hongxin Sun, Shigekuni Hosogi, Takashi Nakahari, Toshio Inui, Yasuaki Kumamoto, Hideo Tanaka, and Yoshinori Marunaka
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Medicine ,Science - Abstract
Abstract The typical response to the lowering of plasma Na+ concentration and blood pressure in our body involves the release of aldosterone from the adrenal glands, which triggers the reabsorption of sodium in the kidney. Although the effects of aldosterone on this physiological mechanism were extensively studied in the past decades, there are still some aspects to be fully elucidated. In the present study, we propose for the first time a new approach based on Raman spectroscopy to monitor the ionic activity in aldosterone-treated A6 renal epithelial cells. This spectroscopic technique is capable of probing the cells through their thickness in a non-destructive and nimble way. The spectroscopic variations of the Raman bands associated to the O-H stretching of water were correlated to the variations of ionic concentration in the intracellular and extracellular fluids. The increase of Na+ concentration gradients was clearly visualized in the cytosol of aldosterone-treated cells. The enhancement of the Na+ current density induced by aldosterone was estimated from the variation of the ionic chemical potential across the intracellular space. In addition, the variation of the O-H Raman bands of water was used to quantify the cell thickness, which was not affected by aldosterone.
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- 2017
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24. Rapid and accurate peripheral nerve imaging by multipoint Raman spectroscopy
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Yasuaki Kumamoto, Yoshinori Harada, Hideo Tanaka, and Tetsuro Takamatsu
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Medicine ,Science - Abstract
Abstract Raman spectroscopy allows label-free, minimally invasive, and accurate detection of peripheral nerves. However, the conventional Raman imaging technique is time-consuming when measuring a large area of a sample. Establishing a method for rapidly acquiring spatial distribution of a bundle of peripheral nerve fibers is an essential step for Raman spectroscopy towards application in clinical surgery. Here we present a multipoint Raman spectroscopic technique for rapid peripheral nerve imaging. In only 5 seconds, spectra at 32 points situated on ex vivo rat peripheral nerve bundles and adjoining connective tissues were acquired. Principal component regression and discriminant analysis of spectra revealed that the sensitivity, specificity and accuracy for nerve detection were 85.8%, 96.0%, and 90.8%, respectively. Of 158 peripheral nerves, 152 (96.2%) showed ratio of the number of nerve-positive prediction points to the total measurement points being 0.4 or larger, whereas 119 (99.2%) connective tissues among 120 showed ratio smaller than 0.4. Based on the ratio and a bright-field image of the sample, accurate visualization of peripheral nerves was implemented. The results indicated that the multipoint Raman spectroscopic technique is capable of rapid and accurate peripheral nerve imaging.
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- 2017
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25. Hepatocellular carcinoma in children and young patients with chronic HBV infection and the usefulness of alpha‐fetoprotein assessment
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Hitoshi Tajiri, Tomoko Takano, Hideo Tanaka, Kosuke Ushijima, Ayano Inui, Yoko Miyoshi, Keiichi Ozono, Daiki Abukawa, Takeshi Endo, Stephen Brooks, and Yasuhito Tanaka
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alpha‐fetoprotein ,HBeAg seroconversion ,hepatocellular carcinoma ,interferon ,liver cirrhosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract The aims of the study were to elucidate the clinical characteristics of patients who developed hepatocellular carcinoma (HCC) related to persistent HBV infection since childhood and to investigate usefulness of assessing alpha‐fetoprotein (AFP) in this population. A nationwide multicenter survey of children with chronic HBV infection was performed. Among 548 patients, 15 patients developed HCC at the median age of 15 years (range 9–36), including 13 males and 2 females. A case–control comparison showed that HBeAg seroconversion and liver cirrhosis were associated with the occurrence of HCC. Of the 15 HCC patients, 5 were treated with interferon and none of them responded to interferon therapy as compared with 12 of the 17 responders in the control group. Of the 15 patients, 10 died and 9 of the 10 who died never visited any medical facilities until diagnosis of HCC, while the remaining 5 surviving patients never stopped their clinic visits. The usefulness of AFP assessment was shown by the findings that AFP levels were elevated in all HCC cases, that elevations in AFP levels were detected prior to the diagnosis in the surviving patients, and that sensitivity of AFP as a diagnostic test for HCC was very high among 40 patients including our 14 and an additional 26 collected from the literature. HBeAg seroconversion and liver cirrhosis are associated with the occurrence of HCC. Regular measurement of AFP might be helpful to watch for the occurrence of HCC when following children and young patients with chronic HBV infection since childhood
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- 2016
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26. Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis
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Junmi Tanaka, Hideo Tanaka, Nobuhisa Mizuki, Eiichi Nomura, Naoko Nomura, Masayuki Yamane, Tomonobu Hida, Yoshio Goshima, Hiroshi Hatano, and Hisashi Nakagawa
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Semaphorin 3A ,experimental allergic conjunctivitis ,eosinophil infiltration ,serum total IgE ,cytokines ,instillation ,subconjunctival administration ,Ophthalmology ,RE1-994 - Abstract
AIM: To assess the efficacy of topical Semaphorin-3A (SEMA3A) in the treatment of allergic conjunctivitis. METHODS: Experimental allergic conjunctivitis (EAC) mice model induced by short ragweed pollen (SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin (H&E) staining, immunofluorescence and light microscope photographs. Early phase took the samples in 24h after instillation and late phase took the samples between 4 to 14d after the start of treatment. The study use of topical SEMA3A (10 U, 100 U, 1000 U) eye drops and subconjunctival injection of SEMA3A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics. RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3A 1000 U-treated group were significantly lower than low-concentration of SEMA3A treated groups and non-treated group. SEMA3A treatment also suppressed T-cell proliferation in vitro and decreased serum total IgE levels in EAC mice. Moreover, Treatment of SEMA3A suppressed Th2-related cytokines (IL-5, IL-13 and IL-4) and pro-inflammatory cytokines (IFN-γ, IL-17 and TNF-α) release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice. CONCLUSIONS: SEMA3A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future.
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- 2015
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27. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.
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Yuh Shiwa, Tsuyoshi Hachiya, Ryohei Furukawa, Hideki Ohmomo, Kanako Ono, Hisaaki Kudo, Jun Hata, Atsushi Hozawa, Motoki Iwasaki, Koichi Matsuda, Naoko Minegishi, Mamoru Satoh, Kozo Tanno, Taiki Yamaji, Kenji Wakai, Jiro Hitomi, Yutaka Kiyohara, Michiaki Kubo, Hideo Tanaka, Shoichiro Tsugane, Masayuki Yamamoto, Kenji Sobue, and Atsushi Shimizu
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Medicine ,Science - Abstract
Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. In Experiment 1, whole blood from 16 volunteers was collected to examine the effect of a 24 h storage period at 4°C on DNA methylation profiles as measured using the Infinium HumanMethylation450 BeadChip array. Our statistical analysis showed that the P-value distribution of more than 450,000 CpG sites was similar to the theoretical distribution (in quantile-quantile plot, λ = 1.03) when comparing two control replicates, which was remarkably deviated from the theoretical distribution (λ = 1.50) when comparing control and storage conditions. We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λ adjusted = 1.14) by taking into account a cell-type composition variable. As such, we compared four respective sample collection protocols used in large-scale Japanese biobanks or cohorts as well as two control replicates. Systematic biases in DNA methylation profiles were observed between control and three of four protocols without adjustment of cell-type composition (λ = 1.12-1.45) and no remarkable biases were seen after adjusting for cell-type composition in all four protocols (λ adjusted = 1.00-1.17). These results revealed important implications for comparing DNA methylation profiles between blood specimens from different sources and may lead to discovery of disease-associated DNA methylation markers and the development of DNA methylation profile-based predictive risk models.
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- 2016
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28. Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts.
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Wei Zheng, Dale F McLerran, Betsy A Rolland, Zhenming Fu, Paolo Boffetta, Jiang He, Prakash Chandra Gupta, Kunnambath Ramadas, Shoichiro Tsugane, Fujiko Irie, Akiko Tamakoshi, Yu-Tang Gao, Woon-Puay Koh, Xiao-Ou Shu, Kotaro Ozasa, Yoshikazu Nishino, Ichiro Tsuji, Hideo Tanaka, Chien-Jen Chen, Jian-Min Yuan, Yoon-Ok Ahn, Keun-Young Yoo, Habibul Ahsan, Wen-Harn Pan, You-Lin Qiao, Dongfeng Gu, Mangesh Suryakant Pednekar, Catherine Sauvaget, Norie Sawada, Toshimi Sairenchi, Gong Yang, Renwei Wang, Yong-Bing Xiang, Waka Ohishi, Masako Kakizaki, Takashi Watanabe, Isao Oze, San-Lin You, Yumi Sugawara, Lesley M Butler, Dong-Hyun Kim, Sue K Park, Faruque Parvez, Shao-Yuan Chuang, Jin-Hu Fan, Chen-Yang Shen, Yu Chen, Eric J Grant, Jung Eun Lee, Rashmi Sinha, Keitaro Matsuo, Mark Thornquist, Manami Inoue, Ziding Feng, Daehee Kang, and John D Potter
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Medicine - Abstract
BackgroundTobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest.Methods and findingsWe performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then estimated smoking-related deaths among adults aged ≥45 y in 2004 in Bangladesh, India, mainland China, Japan, Republic of Korea, Singapore, and Taiwan-accounting for ∼71% of Asia's total population. An approximately 1.44-fold (95% CI = 1.37-1.51) and 1.48-fold (1.38-1.58) elevated risk of death from any cause was found in male and female ever-smokers, respectively. In 2004, active tobacco smoking accounted for approximately 15.8% (95% CI = 14.3%-17.2%) and 3.3% (2.6%-4.0%) of deaths, respectively, in men and women aged ≥45 y in the seven countries/regions combined, with a total number of estimated deaths of ∼1,575,500 (95% CI = 1,398,000-1,744,700). Among men, approximately 11.4%, 30.5%, and 19.8% of deaths due to cardiovascular diseases, cancer, and respiratory diseases, respectively, were attributable to tobacco smoking. Corresponding proportions for East Asian women were 3.7%, 4.6%, and 1.7%, respectively. The strongest association with tobacco smoking was found for lung cancer: a 3- to 4-fold elevated risk, accounting for 60.5% and 16.7% of lung cancer deaths, respectively, in Asian men and East Asian women aged ≥45 y.ConclusionsTobacco smoking is associated with a substantially elevated risk of mortality, accounting for approximately 2 million deaths in adults aged ≥45 y throughout Asia in 2004. It is likely that smoking-related deaths in Asia will continue to rise over the next few decades if no effective smoking control programs are implemented. Please see later in the article for the Editors' Summary.
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- 2014
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29. Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study
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Hinako Nanri, Yuichiro Nishida, Kazuyo Nakamura, Keitaro Tanaka, Mariko Naito, Guang Yin, Nobuyuki Hamajima, Naoyuki Takashima, Sadao Suzuki, Yora Nindita, Michiko Kohno, Hirokazu Uemura, Teruhide Koyama, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, and Hideo Tanaka
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dietary pattern ,factor analysis ,β-adrenergic receptor (ADRβ) ,polymorphism ,triglyceride ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
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- 2016
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30. Impact of PSCA variation on gastric ulcer susceptibility.
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Chizu Tanikawa, Keitaro Matsuo, Michiaki Kubo, Atsushi Takahashi, Hidemi Ito, Hideo Tanaka, Yasushi Yatabe, Kenji Yamao, Naoyuki Kamatani, Kazuo Tajima, Yusuke Nakamura, and Koichi Matsuda
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Medicine ,Science - Abstract
Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10(-7)) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.
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- 2013
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31. Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the Japanese population.
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Akihiko Nakamura, Hideshi Niimura, Kazuyo Kuwabara, Toshiro Takezaki, Emi Morita, Kenji Wakai, Nobuyuki Hamajima, Yuichiro Nishida, Tanvir Chowdhury Turin, Sadao Suzuki, Keizo Ohnaka, Hirokazu Uemura, Etsuko Ozaki, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, and Hideo Tanaka
- Subjects
Medicine ,Science - Abstract
BACKGROUND/OBJECTIVE: Gene-gene interactions in the reverse cholesterol transport system for high-density lipoprotein-cholesterol (HDL-C) are poorly understood. The present study observed gene-gene combination effect and interactions between single nucleotide polymorphisms (SNPs) in ABCA1, APOA1, SR-B1, and CETP in serum HDL-C from a cross-sectional study in the Japanese population. METHODS: The study population comprised 1,535 men and 1,515 women aged 35-69 years who were enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We selected 13 SNPs in the ABCA1, APOA1, CETP, and SR-B1 genes in the reverse cholesterol transport system. The effects of genetic and environmental factors were assessed using general linear and logistic regression models after adjusting for age, sex, and region. PRINCIPAL FINDINGS: Alcohol consumption and daily activity were positively associated with HDL-C levels, whereas smoking had a negative relationship. The T allele of CETP, rs3764261, was correlated with higher HDL-C levels and had the highest coefficient (2.93 mg/dL/allele) among the 13 SNPs, which was statistically significant after applying the Bonferroni correction (p
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- 2013
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32. Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study
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Asahi Hishida, Kenji Wakai, Mariko Naito, Takashi Tamura, Sayo Kawai, Nobuyuki Hamajima, Isao Oze, Takeshi Imaizumi, Tanvir Chowdhury Turin, Sadao Suzuki, Motahare Kheradmand, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Kokichi Arisawa, Michiaki Kubo, and Hideo Tanaka
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Biology (General) ,QH301-705.5 - Abstract
Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR
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- 2013
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33. Bilateral Cochlear Implantation for Children in Nagasaki, Japan
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Yukihiko Kanda, Hidetaka Kumagami, Minoru Hara, Yuzuru Sainoo, Chisei Sato, Tomomi Yamamoto-Fukuda, Haruo Yoshida, Akiko Ito, Chiharu Tanaka, Kyoko Baba, Ayaka Nakata, Hideo Tanaka, and Haruo Takahashi
- Subjects
Cochlear implant ,Children ,Bilateral ,Binaural ,Binaural summation ,Head shadow effect ,Japan ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
ObjectivesThe number of patients with bilateral cochlear implant (CI) has gradually increased as patients and/or parents recognize its effectiveness. The purpose of this report is to evaluate the efficacy of 29 bilateral CI out of 169 pediatric CI users, who received auditory-verbal/oral habilitation at our hearing center.MethodsWe evaluated the audiological abilities 29 Japanese children with bilateral CIs including wearing threshold, word recognition score, speech discrimination score at 1 m from front speaker (SP), 1 m from second CI side SP, speech discrimination score under the noise (S/N ratio=80 dB sound pressure level [SPL]/70 dB SPL, 10 dB) at 1 m from front SP, word recognition score under the noise (S/N ratio=80 dB SPL/70 dB SPL, 10 dB) at 1 m from front SP.ResultsBinaural hearing using bilateral CI is better than first CI in all speech understanding tests. Especially, there were significant differences between the results of first CI and bilateral CI on SDS at 70 dB SPL (P=0.02), SDS at 1 m from second CI side SP at 60 dB SPL (P=0.02), word recognition score (WRS) at 1 m from second CI side SP at 60 dB SPL (P=0.02), speech discrimination score (SDS) at 1 m from front SP under the noise (S/N=80/70; P=0.01) and WRS at 1 m from front SP under the noise (S/N=80/70; P=0.002). At every age, a second CI is very effective. However, the results of under 9 years old were better than of over 9 years old on the mean SDS under the noise (S/N=80/70) on second CI (P=0.04). About use of a hearing aid (HA) in their opposite side of first CI, on the WRS and SDS under the noise, there were significant differences between the group of over 3 years and the group of under 10 months of HA non user before second CI.ConclusionThese results may show important binaural effectiveness such as binaural summation and head shadow effect. Bilateral CI is very useful medical intervention for many children with severe-to-profound hearing loss in Japan as well as elsewhere.
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- 2012
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34. What Factors Are Associated with Good Performance in Children with Cochlear Implants? From the Outcome of Various Language Development Tests, Research on Sensory and Communicative Disorders Project in Japan: Nagasaki Experience
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Yukihiko Kanda, Hidetaka Kumagami, Minoru Hara, Yuzuru Sainoo, Chisei Sato, Tomomi Yamamoto-Fukuda, Haruo Yoshida, Akiko Ito, Chiharu Tanaka, Kyoko Baba, Ayaka Nakata, Hideo Tanaka, Kunihiro Fukushima, Norio Kasai, and Haruo Takahashi
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Cochlear implant ,Children ,Research on sensory and communicative disorders ,Language development ,Japan ,Medicine ,Otorhinolaryngology ,RF1-547 - Abstract
ObjectivesWe conducted multi-directional language development tests as a part of the Research on Sensory and Communicative Disorders (RSVD) in Japan. This report discusses findings as well as factors that led to better results in children with severe-profound hearing loss.MethodsWe evaluated multiple language development tests in 33 Japanese children with cochlear implants (32 patients) and hearing aid (1 patient), including 1) Test for question and answer interaction development, 2) Word fluency test, 3) Japanese version of the Peabody picture vocabulary test-revised, 4) The standardized comprehension test of abstract words, 5) The screening test of reading and writing for Japanese primary school children, 6) The syntactic processing test of aphasia, 7) Criterion-referenced testing (CRT) for Japanese language and mathematics, 8) Pervasive development disorders ASJ rating scales, and 9) Raven's colored progressive matrices. Furthermore, we investigated the factors believed to account for the better performances in these tests. The first group, group A, consisted of 14 children with higher scores in all tests than the national average for children with hearing difficulty. The second group, group B, included 19 children that scored below the national average in any of the tests.ResultsOverall, the results show that 76.2% of the scores obtained by the children in these tests exceeded the national average scores of children with hearing difficulty. The children who finished above average on all tests had undergone a longer period of regular habilitation in our rehabilitation center, had their implants earlier in life, were exposed to more auditory verbal/oral communication in their education at affiliated institutions, and were more likely to have been integrated in a regular kindergarten before moving on to elementary school.ConclusionIn this study, we suggest that taking the above four factors into consideration will have an affect on the language development of children with severe-profound hearing loss.
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- 2012
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35. Detailed analysis of Japanese population substructure with a focus on the southwest islands of Japan.
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Takeshi Nishiyama, Hirohisa Kishino, Sadao Suzuki, Ryosuke Ando, Hideshi Niimura, Hirokazu Uemura, Mikako Horita, Keizo Ohnaka, Nagato Kuriyama, Haruo Mikami, Naoyuki Takashima, Keitaro Mastuo, Yin Guang, Kenji Wakai, Nobuyuki Hamajima, Hideo Tanaka, and J-MICC Study Group
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Medicine ,Science - Abstract
Uncovering population structure is important for properly conducting association studies and for examining the demographic history of a population. Here, we examined the Japanese population substructure using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC), which covers all but the northern region of Japan. Using 222 autosomal loci from 4502 subjects, we investigated population substructure by estimating F(ST) among populations, testing population differentiation, and performing principal component analysis (PCA) and correspondence analysis (CA). All analyses revealed a low but significant differentiation between the Amami Islanders and the mainland Japanese population. Furthermore, we examined the genetic differentiation between the mainland population, Amami Islanders and Okinawa Islanders using six loci included in both the Pan-Asian SNP (PASNP) consortium data and the J-MICC data. This analysis revealed that the Amami and Okinawa Islanders were differentiated from the mainland population. In conclusion, we revealed a low but significant level of genetic differentiation between the mainland population and populations in or to the south of the Amami Islands, although genetic variation between both populations might be clinal. Therefore, the possibility of population stratification must be considered when enrolling the islander population of this area, such as in the J-MICC study.
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- 2012
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36. Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.
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Takahisa Kawaguchi, Yoshio Sumida, Atsushi Umemura, Keitaro Matsuo, Meiko Takahashi, Toshinari Takamura, Kohichiroh Yasui, Toshiji Saibara, Etsuko Hashimoto, Miwa Kawanaka, Sumio Watanabe, Sumio Kawata, Yasuharu Imai, Miki Kokubo, Toshihide Shima, Hyohun Park, Hideo Tanaka, Kazuo Tajima, Ryo Yamada, Fumihiko Matsuda, Takeshi Okanoue, and Japan Study Group of Nonalcoholic Fatty Liver Disease
- Subjects
Medicine ,Science - Abstract
Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately 10-30% of NAFLD and causes a higher frequency of liver-related death, and its progression of NASH has been considered to be complex involving multiple genetic factors interacting with the environment and lifestyle.To identify genetic factors related to NAFLD in the Japanese, we performed a genome-wide association study recruiting 529 histologically diagnosed NAFLD patients and 932 population controls. A significant association was observed for a cluster of SNPs in PNPLA3 on chromosome 22q13 with the strongest p-value of 1.4 × 10(-10) (OR = 1.66, 95%CI: 1.43-1.94) for rs738409. Rs738409 also showed the strongest association (p = 3.6 × 10(-6)) with the histological classifications proposed by Matteoni and colleagues based on the degree of inflammation, ballooning degeneration, fibrosis and Mallory-Denk body. In addition, there were marked differences in rs738409 genotype distributions between type4 subgroup corresponding to NASH and the other three subgroups (p = 4.8 × 10(-6), OR = 1.96, 95%CI: 1.47-2.62). Moreover, a subgroup analysis of NAFLD patients against controls showed a significant association of rs738409 with type4 (p = 1.7 × 10(-16), OR = 2.18, 95%CI: 1.81-2.63) whereas no association was obtained for type1 to type3 (p = 0.41). Rs738409 also showed strong associations with three clinical traits related to the prognosis of NAFLD, namely, levels of hyaluronic acid (p = 4.6 × 10(-4)), HbA1c (p = 0.0011) and iron deposition in the liver (p = 5.6 × 10(-4)).With these results we clearly demonstrated that Matteoni type4 NAFLD is both a genetically and clinically different subset from the other spectrums of the disease and that the PNPLA3 gene is strongly associated with the progression of NASH in Japanese population.
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- 2012
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37. Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium.
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Paolo Boffetta, Dale McLerran, Yu Chen, Manami Inoue, Rashmi Sinha, Jiang He, Prakash Chandra Gupta, Shoichiro Tsugane, Fujiko Irie, Akiko Tamakoshi, Yu-Tang Gao, Xiao-Ou Shu, Renwei Wang, Ichiro Tsuji, Shinichi Kuriyama, Keitaro Matsuo, Hiroshi Satoh, Chien-Jen Chen, Jian-Min Yuan, Keun-Young Yoo, Habibul Ahsan, Wen-Harn Pan, Dongfeng Gu, Mangesh Suryakant Pednekar, Shizuka Sasazuki, Toshimi Sairenchi, Gong Yang, Yong-Bing Xiang, Masato Nagai, Hideo Tanaka, Yoshikazu Nishino, San-Lin You, Woon-Puay Koh, Sue K Park, Chen-Yang Shen, Mark Thornquist, Daehee Kang, Betsy Rolland, Ziding Feng, Wei Zheng, and John D Potter
- Subjects
Medicine ,Science - Abstract
The occurrence of diabetes has greatly increased in low- and middle-income countries, particularly in Asia, as has the prevalence of overweight and obesity; in European-derived populations, overweight and obesity are established causes of diabetes. The shape of the association of overweight and obesity with diabetes risk and its overall impact have not been adequately studied in Asia.A pooled cross-sectional analysis was conducted to evaluate the association between baseline body mass index (BMI, measured as weight in kg divided by the square of height in m) and self-reported diabetes status in over 900,000 individuals recruited in 18 cohorts from Bangladesh, China, India, Japan, Korea, Singapore and Taiwan. Logistic regression models were fitted to calculate cohort-specific odds ratios (OR) of diabetes for categories of increasing BMI, after adjustment for potential confounding factors. OR were pooled across cohorts using a random-effects meta-analysis. The sex- and age-adjusted prevalence of diabetes was 4.3% in the overall population, ranging from 0.5% to 8.2% across participating cohorts. Using the category 22.5-24.9 kg/m²) as reference, the OR for diabetes spanned from 0.58 (95% confidence interval [CI] 0.31, 0.76) for BMI lower than 15.0 kg/m² to 2.23 (95% CI 1.86, 2.67) for BMI higher than 34.9 kg/m². The positive association between BMI and diabetes prevalence was present in all cohorts and in all subgroups of the study population, although the association was stronger in individuals below age 50 at baseline (p-value of interaction
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- 2011
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38. Autopsy of a Patient with Primary Pancreatic Lymphoma with Findings Resembling Severe Acute Pancreatitis
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Yoshinori, Harada, Yoshio, Sogame, Ryuta, Nakao, Takehiro, Ogata, Hiroaki, Yasuda, Junichi, Sakagami, Yoshito, Itoh, and Hideo, Tanaka
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Internal Medicine ,General Medicine - Abstract
Primary pancreatic lymphoma is a rare pancreatic malignancy, reportedly accounting for only 0.2-0.7% of all primary pancreatic tumors. Primary pancreatic lymphoma is often difficult to distinguish from other diseases, such as acute pancreatitis. We herein report the autopsy of a patient with primary pancreatic lymphoma with imaging findings resembling those of severe acute pancreatitis, with a focus on the gross and histological features.
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- 2023
39. Lipid droplet accumulation and adipophilin expression in follicular thyroid carcinoma
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Michiyo Hayakawa, J. Nicholas Taylor, Ryuta Nakao, Kentaro Mochizuki, Yuki Sawai, Kosuke Hashimoto, Koji Tabata, Yasuaki Kumamoto, Katsumasa Fujita, Eiichi Konishi, Shigeru Hirano, Hideo Tanaka, Tamiki Komatsuzaki, and Yoshinori Harada
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Follicular thyroid carcinoma ,Adipophilin ,Biophysics ,Lipid droplet ,Cell Biology ,Follicular neoplasm ,Follicular thyroid adenoma ,Molecular Biology ,Biochemistry - Abstract
Follicular neoplasms of the thyroid include follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA). However, the differences in cytological findings between FTC and FTA remain undetermined. Here, we aimed to evaluate the accumulation of lipid droplets (LDs) and the expression of adipophilin (perilipin 2/ADRP/ADFP), a known LD marker, in cultured FTC cells. We also immunohistochemically compared adipophilin expression in the FTC and FTA of resected human thyroid tissues. Cultured FTC (FTC-133 and RO82W-1) possessed increased populations of LDs compared to thyroid follicular epithelial (Nthy-ori 3-1) cells. In vitro treatment with phosphatidylinositol-3-kinase (PI3K)/Akt/ mammalian target of rapamycin (mTOR) signaling inhibitors (LY294002, MK2206, and rapamycin) in FTC-133 cells downregulated the PI3K/Akt/mTOR/sterol regulatory element-binding protein 1 (SREBP1) signaling pathway, resulting in a significant reduction in LD accumulation. SREBP1 is a master transcription factor that controls lipid metabolism. Fluorescence immunocytochemistry revealed adipophilin expression in the LDs of FTC-133 cells. Immunohistochemical analysis of surgically resected human thyroid tissues revealed significantly increased expression of adipophilin in FTC compared with FTA and adjacent non-tumorous thyroid epithelia. Taken together, LDs and adipophilin were abundant in cultured FTC; the evaluation of adipophilin expression can help distinguish FTC from FTA in surgical specimens. (c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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- 2023
40. A low proportion of asymptomatic COVID-19 patients with the Delta variant infection by viral transmission through household contact at the time of confirmation in Ibaraki, Japan
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Tsuyoshi Ogata, Hideo Tanaka, Fujiko Irie, Yumiko Nozawa, Etsuko Noguchi, Kayoko Seo, and Emiko Tanaka
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Communication ,General Medicine - Abstract
We conducted a study to investigate the proportion of patients with asymptomatic coronavirus disease 2019 (COVID-19) infected with the Delta variant compared with those infected with the wild-type strain at the time of confirmation. A total of 504 patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by viral transmission through household contact in Ibaraki, Japan were included. The proportion of asymptomatic COVID-19 patients at the time of confirmation was compared between patients infected with L452R mutation strain from June to September 2021 and those infected with the wild-type strain from November 2020 to January 2021, and was found to be 14.2% and 28.8%, respectively (relative risk, 0.49; 95% confidence interval, 0.35-0.70). The proportion of asymptomatic COVID-19 patients by viral transmission through household contact was lower among the Delta variant than those among the wild-type strain at the time of confirmation. It might contribute to attenuation of transmission.
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- 2022
41. The Conflict between Two Legal Traditions in Making the Constitution of Japan
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Hideo, Tanaka, primary
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- 2019
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42. Data from Folate Intake along with Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase in Patients with Advanced Gastric Cancer
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Keitaro Matsuo, Hideo Tanaka, Yasushi Yatabe, Kazuo Tajima, Miki Watanabe, Takakazu Kawase, Satoyo Hosono, Hidemi Ito, Takashi Ura, Takashi Shibata, Daisuke Takahari, Tomoya Yokota, Hiroki Kawai, Masahiro Tajika, Akira Sawaki, Seiji Ito, Kei Muro, and Kohei Shitara
- Abstract
Background: A relationship between dietary folate intake and efficacy of fluorouracil (FU) is supported by preclinical data. Furthermore, there are several reports that evaluated genetic polymorphisms of MTHFR (methylenetetrahydrofolate reductase) or TYMS (thymidylate synthase) and efficacy of FU. However, to our knowledge, there are no reports that evaluate simultaneously the effects of folate intake and genetic polymorphisms on clinical outcome of gastric cancer patients.Methods: We retrospectively analyzed the survival impact of estimated folate intake by a food frequency questionnaire and MTHFR and TYMS polymorphisms in 132 patients with advanced gastric cancer who were treated with first-line FU-based chemotherapy.Results: Median overall survival was 11.3 months (95% confidence interval, 9.4-13.4 mo) and median progression-free survival was 5.2 months (95% confidence interval, 4.1-6.3 mo). Patients with folate intake of >260 μg/day (n = 88) showed longer overall survival compared with low folate intake (n = 44; overall survival, 12.2 versus 8.4 mo). In a multivariate Cox model, patients who had folate intake of >260 μg/day, MTHFR 677 TT polymorphism, and TYMS-3′ untranslated region 6-bp insertion were associated with better survival. Similar tendency was observed in progression-free survival. No interaction was observed between folate intake and favorable genotypes.Conclusion: Folate intake and genetic polymorphisms of MTHFR and TYMS were associated with better clinical outcome by FU-based chemotherapy in advanced gastric cancer.Impact: Our results suggested folate intake and folate-related genetic polymorphisms may play an important role in efficacy of FU-based chemotherapy in advanced gastric cancer. Cancer Epidemiol Biomarkers Prev; 19(5); 1311–9. ©2010 AACR.
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- 2023
43. Data from Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population
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Hideo Tanaka, Mitsune Tanimoto, Kazuo Tajima, Katsuyuki Kiura, Masayuki Shinoda, Yasuhisa Hasegawa, Yasuhi Yatabe, Shunzo Hatooka, Taijiro Ozawa, Satoyo Hosono, Hidemi Ito, Akio Hiraki, Miki Watanabe, Takakazu Kawase, Takeshi Suzuki, Keitaro Matsuo, and Isao Oze
- Abstract
Alcohol intake is positively associated with the risk of upper aerodigestive tract (UAT) cancer. The genes that encode alcohol-metabolizing enzymes, primarily alcohol dehydrogenases (ADH) and aldehyde dehydrogenases (ALDH), are polymorphic. In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them. Moreover, UAT cancer was significantly associated with rs1573496 in ADH7, and not with rs1984362 in ADH4. However, little evidence is available concerning ADH4 or ADH7 polymorphisms in Asian populations. We conducted a matched case-control study to clarify the role of ADH polymorphisms in a Japanese population. Cases and controls were 585 patients with UAT cancer and 1,170 noncancer outpatients. Genotyping for ADHs and ALDH2 was done using TaqMan assays. Associations between polymorphisms and UAT cancer were assessed by odds ratios and 95% confidence intervals using conditional logistic regression models that adjusted for age, sex, smoking, drinking, and ALDH2. Adjusted odds ratios were significant for rs4148887 and rs3805322 in ADH4, rs1229984 in ADH1B, rs698 and rs1693482 in ADH1C, and rs284787, rs1154460, and rs3737482 in ADH7. We also observed that ADH7 rs3737482 and ADH4 rs4148887 had independently and statistically significant effects on UAT cancer. The magnitude of effect of these ADH polymorphisms was greater in subjects who were heavy drinkers, heavy smokers, and had esophageal cancer. These findings show that multiple ADH gene polymorphisms were associated with UAT cancer in this Japanese population. Further studies in various ethnicities are required. (Cancer Epidemiol Biomarkers Prev 2009;18(11):3097–102)
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- 2023
44. Supplementary Table and Figures 1-6 from Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population
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Hideo Tanaka, Mitsune Tanimoto, Kazuo Tajima, Katsuyuki Kiura, Masayuki Shinoda, Yasuhisa Hasegawa, Yasuhi Yatabe, Shunzo Hatooka, Taijiro Ozawa, Satoyo Hosono, Hidemi Ito, Akio Hiraki, Miki Watanabe, Takakazu Kawase, Takeshi Suzuki, Keitaro Matsuo, and Isao Oze
- Abstract
Supplementary Table and Figures 1-6 from Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population
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- 2023
45. Supplementary Tables 1-3 from Folate Intake along with Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase in Patients with Advanced Gastric Cancer
- Author
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Keitaro Matsuo, Hideo Tanaka, Yasushi Yatabe, Kazuo Tajima, Miki Watanabe, Takakazu Kawase, Satoyo Hosono, Hidemi Ito, Takashi Ura, Takashi Shibata, Daisuke Takahari, Tomoya Yokota, Hiroki Kawai, Masahiro Tajika, Akira Sawaki, Seiji Ito, Kei Muro, and Kohei Shitara
- Abstract
Supplementary Tables 1-3 from Folate Intake along with Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase in Patients with Advanced Gastric Cancer
- Published
- 2023
46. The experiencing model
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Akira Ikemi, Shimpei Okamura, and Hideo Tanaka
- Published
- 2023
47. Raman imaging of rat nonalcoholic fatty liver tissues reveals distinct biomolecular states
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Khalifa Mohammad Helal, Harsono Cahyadi, J. Nicholas Taylor, Akira Okajima, Koji Tabata, Yasuaki Kumamoto, Kentaro Mochizuki, Yoshito Itoh, Tetsuro Takamatsu, Hideo Tanaka, Katsumasa Fujita, Tamiki Komatsuzaki, and Yoshinori Harada
- Subjects
nonalcoholic fatty liver disease ,Structural Biology ,nonalcoholic fatty liver ,Raman imaging ,Genetics ,Biophysics ,Cell Biology ,nonalcoholic steatohepatitis ,Molecular Biology ,Biochemistry - Abstract
An essential challenge in diagnosing states of nonalcoholic fatty liver disease (NAFLD) is the early prediction of progression from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) before the disease progresses. Histological diagnoses of NAFLD rely on the appearance of anomalous tissue morphologies, and it is difficult to segment the biomolecular environment of the tissue through a conventional histopathological approach. Here, we show that hyperspectral Raman imaging provides diagnostic information on NAFLD in rats, as spectral changes among disease states can be detected before histological characteristics emerge. Our results demonstrate that Raman imaging of NAFLD can be a useful tool for histopathologists, offering biomolecular distinctions among tissue states that cannot be observed through standard histopathological means.
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- 2023
48. High-throughput line-illumination Raman microscopy with multislit detection
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Kentaro Mochizuki, Yasuaki Kumamoto, Shunsuke Maeda, Masato Tanuma, Atsushi Kasai, Masashi Takemura, Yoshinori Harada, Hitoshi Hashimoto, Hideo Tanaka, Nicholas Isaac Smith, and Katsumasa Fujita
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Atomic and Molecular Physics, and Optics ,Article ,Biotechnology - Abstract
Raman microscopy is an emerging tool for molecular imaging and analysis of living samples. Use of Raman microscopy in life sciences is, however, still limited because of its slow measurement speed for spectral imaging and analysis. We developed a multiline-illumination Raman microscope to achieve ultrafast Raman spectral imaging. A spectrophotometer equipped with a periodic array of confocal slits detects Raman spectra from a sample irradiated by multiple line illuminations. A comb-like Raman hyperspectral image is formed on a two-dimensional detector in the spectrophotometer, and a hyperspectral Raman image is acquired by scanning the sample with multiline illumination array. By irradiating a sample with 21 simultaneous illumination lines, we achieved high-throughput Raman hyperspectral imaging of mouse brain tissue, acquiring 1108800 spectra in 11.4 min. We also measured mouse kidney and liver tissue as well as conducted label-free live-cell molecular imaging. The ultrafast Raman hyperspectral imaging enabled by the presented technique will expand the possible applications of Raman microscopy in biological and medical fields.
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- 2023
49. Change over Time in the Risk of Death among Japanese COVID-19 Cases Caused by the Omicron Variant Depending on Prevalence of Sublineages
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Yuki Takahashi, Hideo Tanaka, Yoshitaka Koga, Shunichi Takiguchi, Shigeru Ogimoto, Shizuyo Inaba, Hiroyuki Matsuoka, Yuka Miyajima, Takeshi Takagi, Fujiko Irie, Yoshihito Bamba, Fuyo Yoshimi, Tomoyuki Suzuki, Isao Araki, Chika Shirai, Sayuri Matsumoto, Motoyuki Shimizu, Toshiyuki Shibata, Hitomi Nagai, Masaru Kinoshita, Rie Fujita, and Tsuyoshi Ogata
- Subjects
case fatality rate ,SARS-CoV-2 ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Japanese ,Omicron variant - Abstract
To assess temporal changes to the risk of death in COVID-19 cases caused by the Omicron variant, we calculated age-standardized case fatality rates (CFR) in patients aged ≥40 years over nine diagnostic periods (3 January to 28 August 2022) in ten Japanese prefectures (14.8 million residents). Among 552,581 study subjects, we found that there were 1836 fatalities during the isolation period (up to 28 days from date of onset). The highest age-standardized CFR (0.85%, 95% confidence interval (CI):0.78–0.92) was observed in cases diagnosed in the second 4-week period (January 31 to February 27), after which it declined significantly up to the 6th 4-week period (0.23%, 95% CI: 0.13–0.33, May 23 to June 19). The CFR then increased again but remained at 0.39% in the eighth period (July 18 to August 28). The CFR in cases with the BA.2 or BA.5 sublineages in the age range 60–80 years was significantly lower than that with BA.1 infections (60 years: 0.19%, 0.02%, 0.053%, respectively; 70 years: 0.91%, 0.33%, 0.39%; ≥80 years: 3.78%, 1.96%, 1.81%, respectively). We conclude that the risk of death in Japanese COVID-19 patients infected with Omicron variants declined through February to mid-June 2022.
- Published
- 2023
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50. Electroreductive Carbon-Carbon Bond-Making Reactions in Pb(O)/Pb(II) Redox Mediatory Systems. 'Barbier Type' Allylation and Hydrocoupling of Imines in an Undivided Cell
- Author
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Hideo Tanaka, Takao Nakahara, Hamid Dhimane, and Sigeru Torii
- Published
- 2023
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