Search

Your search keyword '"Hiemstra, Ida H."' showing total 37 results
Start Over Author "Hiemstra, Ida H."
37 results on '"Hiemstra, Ida H."'

2. Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity

Author

Hiemstra, Ida H., Santegoets, Kim C.M., Janmaat, Maarten L., De Goeij, Bart E.C.G., Ten Hagen, Wessel, van Dooremalen, Sanne, Boross, Peter, van den Brakel, Jeroen, Bosgra, Sieto, Andringa, Grietje, van Kessel-Welmers, Berris, Verzijl, Dennis, Hibbert, Richard G., Frerichs, Kristine A., Mutis, Tuna, van de Donk, Niels W.C.J., Ahmadi, Tahamtan, Satijn, David, Sasser, A. Kate, and Breij, Esther C.W.

Published
2023
Full Text
View/download PDF

3. DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Author

Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, and Breij, Esther C.W.

Published
2020
Full Text
View/download PDF

6. Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

Author

Grassi, Luigi, Pourfarzad, Farzin, Ullrich, Sebastian, Merkel, Angelika, Were, Felipe, Carrillo-de-Santa-Pau, Enrique, Yi, Guoqiang, Hiemstra, Ida H., Tool, Anton T.J., Mul, Erik, Perner, Juliane, Janssen-Megens, Eva, Berentsen, Kim, Kerstens, Hinri, Habibi, Ehsan, Gut, Marta, Yaspo, Marie Laure, Linser, Matthias, Lowy, Ernesto, Datta, Avik, Clarke, Laura, Flicek, Paul, Vingron, Martin, Roos, Dirk, van den Berg, Timo K., Heath, Simon, Rico, Daniel, Frontini, Mattia, Kostadima, Myrto, Gut, Ivo, Valencia, Alfonso, Ouwehand, Willem H., Stunnenberg, Hendrik G., Martens, Joost H.A., and Kuijpers, Taco W.

Published
2018
Full Text
View/download PDF

7. Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment

Author

van der Horst, Hilma J., de Jonge, A. Vera, Hiemstra, Ida H., Gelderloos, Anne T., Berry, Daniella R. A. I., Hijmering, Nathalie J., van Essen, Hendrik F., de Jong, Daphne, Chamuleau, Martine E. D., Zweegman, Sonja, Breij, Esther C. W., Roemer, Margaretha G. M., and Mutis, Tuna

Published
2021
Full Text
View/download PDF

8. P816: PHARMACODYNAMIC ACTIVITY OF GEN3014 (HEXABODY-CD38) IN PATIENTS WITH MULTIPLE MYELOMA SUPPORTS ENHANCED COMPLEMENT DEPENDENT CYTOTOXICITY OF GEN3014 COMPARED TO DARATUMUMAB

Author

Hiemstra, Ida H., primary, Santegoets, Kim, additional, Janmaat, Maarten, additional, Ten Hagen, Wessel, additional, Sanchez, Rosanna, additional, Brady, Lauren, additional, Bosgra, Sieto, additional, Overdijk, Marije, additional, Chen, Jenny, additional, Fladeland Iversen, Katrine, additional, Plesner, Torben, additional, and Breij, Esther, additional

Published
2023
Full Text
View/download PDF

10. Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody (R)-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)

Author

Spencer, Andrew, Iversen, Katrine Fladeland, Dhakal, Binod, Creignou, Maria, Chen, Jenny, Hiemstra, Ida H, Bosgra, Sieto, Badani, Avani, Breij, Esther C. W., Brady, Lauren K., Sasser, A. Kate, Malmberg, Anders, Gregersen, Henrik, Hansson, Markus, Broijl, Annemiek, Mateos, Maria-Victoria, and Plesner, Torben

Subjects
Immunology, Cell Biology, Hematology, Biochemistry
Published
2022
Full Text
View/download PDF

11. Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)

Author

Spencer, Andrew, primary, Iversen, Katrine Fladeland, additional, Dhakal, Binod, additional, Creignou, Maria, additional, Chen, Jenny, additional, Hiemstra, Ida H, additional, Bosgra, Sieto, additional, Badani, Avani, additional, Breij, Esther C.W., additional, Brady, Lauren K., additional, Sasser, A. Kate, additional, Malmberg, Anders, additional, Gregersen, Henrik, additional, Hansson, Markus, additional, Broijl, Annemiek, additional, Mateos, Maria-Victoria, additional, and Plesner, Torben, additional

Published
2022
Full Text
View/download PDF

12. Semimechanistic Physiologically‐Based Pharmacokinetic/Pharmacodynamic Model Informing Epcoritamab Dose Selection for Patients With B‐Cell Lymphomas

Author

Li, Tommy, primary, Hiemstra, Ida H., additional, Chiu, Christopher, additional, Oliveri, Roberto S., additional, Elliott, Brian, additional, DeMarco, Dena, additional, Salcedo, Theodora, additional, Egerod, Frederikke Lihme, additional, Sasser, Kate, additional, Ahmadi, Tahamtan, additional, and Gupta, Manish, additional

Published
2022
Full Text
View/download PDF

17. Abstract 1574: Preclinical evaluation of epcoritamab combined with standard of care therapies for the treatment of B-cell lymphomas

Author

Chiu, Christopher W., primary, Hiemstra, Ida H., additional, Hagen, Wessel ten, additional, Snijdewint-Nkairi, Rajaa, additional, de Jong, Bart, additional, Oliveri, Roberto S., additional, Elliot, Brian, additional, Szafer-Glusman, Edith, additional, Schuurhuis, Danita, additional, Blaedel, Julie, additional, Ahmadi, Tahamatan, additional, Breij, Esther, additional, Sasser, A. Kate, additional, and Jure-Kunkel, Maria, additional

Published
2021
Full Text
View/download PDF

18. Preclinical Anti-Tumor Activity of Hexabody-CD38 in Patient-Derived B Cell Lymphoma and Acute Myeloid Leukemia Xenograft Models

Author

Hiemstra, Ida H, primary, Janmaat, Maarten L, additional, Boross, Peter, additional, van den Brakel, Jeroen, additional, ten Hagen, Wessel, additional, van Dooremalen, Sanne, additional, Bosgra, Sieto, additional, De Goeij, Bart ECG, additional, Andringa, Grietje, additional, Kil, Laurens, additional, Sasser, A Kate, additional, Ahmadi, Tahamtan, additional, Satijn, David, additional, and Breij, Esther CW, additional

Published
2020
Full Text
View/download PDF

21. Duobody-CD3xCD20 Induces Potent Anti-Tumor Activity in Malignant Lymph Node B Cells from Patients with DLBCL, FL and MCL Ex Vivo, Irrespective of Prior Treatment with CD20 Monoclonal Antibodies

Author

Van Der Horst, Hilma J, primary, de Jonge, A. Vera, additional, Hiemstra, Ida H, additional, Gelderloos, Anne T, additional, Berry, Daniella RAI, additional, Hijmering, Nathalie J, additional, de Jong, Daphne, additional, Chamuleau, Martine E.D., additional, Zweegman, Sonja, additional, Breij, Esther CW, additional, Roemer, Margaretha GM, additional, and Mutis, Tuna, additional

Published
2019
Full Text
View/download PDF

22. First-in-Human, Phase 1/2 Trial to Assess the Safety and Clinical Activity of Subcutaneous GEN3013 (DuoBody®-CD3×CD20) in B-Cell Non-Hodgkin Lymphomas

Author

Lugtenburg, Pieternella, primary, Mous, Rogier, primary, Clausen, Michael Roost, primary, Chamuleau, Martine E.D., primary, Johnson, Peter, primary, Linton, Kim, primary, Rule, Simon, primary, Oliveri, Roberto S, primary, DeMarco, Dena, primary, Hiemstra, Ida H, primary, Chen, Guang, primary, Azaryan, Ada, primary, Gupta, Manish, primary, Ahmadi, Tahamtan, primary, and Hutchings, Martin, primary

Published
2019
Full Text
View/download PDF

24. Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

Author

Hoogendijk, Arie J, Pourfarzad, Farzin, Aarts, Cathelijn E M, Tool, Anton T J, Hiemstra, Ida H, Grassi, Luigi, Frontini, Mattia, Meijer, Alexander B, van den Biggelaar, Maartje, Kuijpers, Taco W, Hoogendijk, Arie J, Pourfarzad, Farzin, Aarts, Cathelijn E M, Tool, Anton T J, Hiemstra, Ida H, Grassi, Luigi, Frontini, Mattia, Meijer, Alexander B, van den Biggelaar, Maartje, and Kuijpers, Taco W

Abstract

Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear blood cell have remained poorly defined. Using mass spectrometry-based quantitative proteomics combined with transcriptomic data, we report on the dynamic changes of five developmental stages in the bone marrow and blood. Integration of transcriptomes and proteome unveils highly dynamic and differential interactions between RNA and protein kinetics during human neutrophil development, which can be linked to functional maturation of typical end-stage blood neutrophil killing activities.

Published
2019

25. Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

Author

Afd Biomol.Mass Spect. and Proteomics, Afd Pharmaceutics, Biomolecular Mass Spectrometry and Proteomics, Pharmaceutics, Hoogendijk, Arie J, Pourfarzad, Farzin, Aarts, Cathelijn E M, Tool, Anton T J, Hiemstra, Ida H, Grassi, Luigi, Frontini, Mattia, Meijer, Alexander B, van den Biggelaar, Maartje, Kuijpers, Taco W, Afd Biomol.Mass Spect. and Proteomics, Afd Pharmaceutics, Biomolecular Mass Spectrometry and Proteomics, Pharmaceutics, Hoogendijk, Arie J, Pourfarzad, Farzin, Aarts, Cathelijn E M, Tool, Anton T J, Hiemstra, Ida H, Grassi, Luigi, Frontini, Mattia, Meijer, Alexander B, van den Biggelaar, Maartje, and Kuijpers, Taco W

Published
2019

26. Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair

Author

Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Aarts, Cathelijn E M, Hiemstra, Ida H, Béguin, Eelke P, Hoogendijk, Arjan J, Bouchmal, Souhailla, van Houdt, Michel, Tool, Anton T J, Mul, Erik, Jansen, Machiel H, Janssen, Hans, van Alphen, Floris P J, de Boer, Jan-Paul, Zuur, Charlotte L, Meijer, Alexander B, van den Berg, Timo K, Kuijpers, Taco W, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Aarts, Cathelijn E M, Hiemstra, Ida H, Béguin, Eelke P, Hoogendijk, Arjan J, Bouchmal, Souhailla, van Houdt, Michel, Tool, Anton T J, Mul, Erik, Jansen, Machiel H, Janssen, Hans, van Alphen, Floris P J, de Boer, Jan-Paul, Zuur, Charlotte L, Meijer, Alexander B, van den Berg, Timo K, and Kuijpers, Taco W

Published
2019

27. Duobody-CD3xCD20 Shows Unique and Potent Preclinical Anti-Tumor Activity in Vitro and In Vivo, and Is Being Evaluated Clinically in Patients with B-Cell Malignancies

Author

Hiemstra, Ida H., primary, Engelberts, Patrick J., additional, de Jong, Bart, additional, Schuurhuis, Danita H, additional, Salcedo, Theodora W., additional, Verploegen, Sandra, additional, van der Zee, Marten, additional, Gerritsen, Arnout F., additional, Losic, Nedjad, additional, Horbach, Sjeng, additional, Oliveri, Roberto, additional, Lammerts van Bueren, Jeroen J., additional, Autzen Usher, Pernille, additional, Schuurman, Janine, additional, Parren, Paul W. H. I., additional, and Breij, Esther C. W., additional

Published
2018
Full Text
View/download PDF

28. Epigenomic and functional dynamics of human bone marrow myeloid differentiation to mature blood neutrophils

Author

Grassi, Luigi, primary, Pourfarzad, Farzin, additional, Ullrich, Sebastian, additional, Merkel, Angelika, additional, Were, Felipe, additional, Pau, Enrique Carrillo de Santa, additional, Yi, Guoqiang, additional, Hiemstra, Ida H, additional, Tool, Anton TJ, additional, Mul, Erik, additional, Perner, Juliane, additional, Janssen-Megens, Eva, additional, Berentsen, Kim, additional, Kerstens, Hinri, additional, Habibi, Ehsan, additional, Gut, Marta, additional, Yaspo, Marie Laure, additional, Linser, Matthias, additional, Lowy, Ernesto, additional, Datta, Avik, additional, Clarke, Laura, additional, Flicek, Paul, additional, Vingron, Martin, additional, Roos, Dirk, additional, Berg, Timo K van den, additional, Heath, Simon, additional, Rico, Daniel, additional, Frontini, Mattia, additional, Kostadima, Myrto, additional, Gut, Ivo, additional, Valencia, Alfonso, additional, Ouwehand, Willem H, additional, Stunnenberg, Hendrik G, additional, Martens, Joost HA, additional, and Kuijpers, Taco W, additional

Published
2018
Full Text
View/download PDF

30. Neutrophils in cancer

Author

Treffers, Louise W., primary, Hiemstra, Ida H., additional, Kuijpers, Taco W., additional, Berg, Timo K., additional, and Matlung, Hanke L., additional

Published
2016
Full Text
View/download PDF

34. The identification and developmental requirements of colonic CD169+ macrophages.

Author

Hiemstra, Ida H., Beijer, Marieke R., Veninga, Henrike, Vrijland, Kim, Borg, Ellen G. F., Olivier, Brenda J., Mebius, Reina E., Kraal, Georg, and Haan, Joke M. M.

Subjects
*MACROPHAGES, *GENE expression, *HOMEOSTASIS, *CELLULAR signal transduction, *TUMOR necrosis factors, *LABORATORY mice
Abstract

CD169-positive macrophages in the marginal zone of the spleen and subcapsular sinus of lymph nodes play an important role as gatekeepers, strategically located to capture pathogens. Here we identified a population of CD169-positive macrophages in the colon and investigated which factors influenced their development. Murine colonic CD115+ F4/80lo CD11clo macrophages expressing CD169 were present in the lamina propria, mainly surrounding the crypts. In spite of the high levels of bacterial flora in the colon and the importance of Toll-like receptor signalling in mucosal homeostasis, the presence of CD169+ macrophages was not affected in mice that were deficient in MyD88-mediated Toll-like receptor signalling and in mice in which the bacterial flora was eradicated. Whereas the development of splenic CD169+ macrophages was dependent on lymphotoxin α, colonic CD169+ macrophages were present in normal numbers in lymphotoxin α-deficient mice. In contrast, reduced numbers of CD169+ macrophages were found in the colon of mice deficient in vitamin A, whereas CD169+ macrophages in the spleen were unaffected. In conclusion, we identified a new macrophage subset in the lamina propria of the colon characterized by the expression of CD169. Its differentiation, unlike CD169+ macrophages in lymphoid organs, is independent of lymphotoxin α signalling, but requires vitamin A. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

35. Cytotoxicity of the CD3 × CD20–bispecific antibody epcoritamab in CLL is increased by concurrent BTK or Bcl-2 targeting

Author

Mhibik, Maissa, Gaglione, Erika, Eik, David, Herrick, John, Le, Janet, Ahn, Inhye E., Chiu, Christopher, Wielgos-Bonvallet, Monica, Hiemstra, Ida H, Breij, Esther CW, Chen, Jenny, Reilly, Edward B., Epling-Burnette, Pearlie K., Szafer-Glusman, Edith, Sun, Clare, and Wiestner, Adrian

Abstract

•Epcoritamab-mediated killing of CLL cells by autologous T cells correlates with the effector-to-target ratio but not CD20 expression.•Epcoritamab efficacy is increased by concurrent use of a BTKi or venetoclax, supporting combination therapy.

Published
2023
Full Text
View/download PDF

36. Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils

Author

Grassi, Luigi, Pourfarzad, Farzin, Ullrich, Sebastian, Merkel, Angelika, Were, Felipe, Carrillo-De-Santa-Pau, Enrique, Yi, Guoqiang, Hiemstra, Ida H, Tool, Anton TJ, Mul, Erik, Perner, Juliane, Janssen-Megens, Eva, Berentsen, Kim, Kerstens, Hinri, Habibi, Ehsan, Gut, Marta, Yaspo, Marie Laure, Linser, Matthias, Lowy, Ernesto, Datta, Avik, Clarke, Laura, Flicek, Paul, Vingron, Martin, Roos, Dirk, Van Den Berg, Timo K, Heath, Simon, Rico, Daniel, Frontini, Mattia, Kostadima, Myrto, Gut, Ivo, Valencia, Alfonso, Ouwehand, Willem H, Stunnenberg, Hendrik G, Martens, Joost HA, and Kuijpers, Taco W

Subjects
Gene Expression Regulation, Neutrophils, epigenome, myeloid differentiation, neutrophil, Humans, Bone Marrow Cells, Cell Differentiation, transcriptome, Chromatin, 3. Good health
Abstract

Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors to mature circulating cells. Integration of chromatin modifications, methylation, and transcriptome dynamics reveals an enforced regulation of differentiation, for cellular functions such as release of proteases, respiratory burst, cell cycle regulation, and apoptosis. We observe an early establishment of the cytotoxic capability, while the signaling components that activate these antimicrobial mechanisms are transcribed at later stages, outside the bone marrow, thus preventing toxic effects in the bone marrow niche. Altogether, these data reveal how the developmental dynamics of the chromatin landscape orchestrate the daily production of a large number of neutrophils required for innate host defense and provide a comprehensive overview of differentiating human neutrophils.

37. Duobody-CD3xCD20 Shows Unique and Potent Preclinical Anti-Tumor Activity in Vitroand In Vivo, and Is Being Evaluated Clinically in Patients with B-Cell Malignancies

Author

Hiemstra, Ida H., Engelberts, Patrick J., de Jong, Bart, Schuurhuis, Danita H, Salcedo, Theodora W., Verploegen, Sandra, van der Zee, Marten, Gerritsen, Arnout F., Losic, Nedjad, Horbach, Sjeng, Oliveri, Roberto, Lammerts van Bueren, Jeroen J., Autzen Usher, Pernille, Schuurman, Janine, Parren, Paul W. H.I., and Breij, Esther C.W.

Abstract

DuoBody®-CD3xCD20 (GEN3013) is a bispecific antibody (bsAb), recognizing the T-cell antigen CD3 and the B-cell antigen CD20, that triggers potent T-cell-mediated lysis of CD20-expressing cells. DuoBody-CD3xCD20 is a full-length bispecific IgG1 generated by controlled Fab-arm exchange (cFAE) [1, 2] and contains an effector function-silenced Fc region.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results