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4. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G., Chen, Jing, Packer, Richard, Hall, Robert J., Guyatt, Anna L., Batini, Chiara, Thompson, Rebecca J., Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D., Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A., John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y., Chen, Zhengming, Li, Liming, Wijnant, Sara R. A., Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G., Manichaikul, Ani, Oelsner, Elizabeth C., Rich, Stephen S., Barr, R. Graham, Kerr, Shona M., Vitart, Veronique, Brown, Michael R., Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M., Gharib, Sina A., Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E., Meyers, Deborah A., Bleecker, Eugene R., Gabriel, Stacey B., Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F., Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H., Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L., Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T., Thareja, Gaurav, Albagha, Omar M. E., Suhre, Karsten, Granell, Raquel, Faquih, Tariq O., Hiemstra, Pieter S., Slats, Annelies M., Mullin, Benjamin H., Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T., Wyss, Annah B., Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A., Joshi, Peter K., Timmers, Paul R. H. J., Williams, Alexander T., Free, Robert C., Wang, Xueyang, Morrison, John L., Gilliland, Frank D., Chen, Zhanghua, Wang, Carol A., Foong, Rachel E., Harris, Sarah E., Taylor, Adele, Redmond, Paul, Cook, James P., Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T., Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H., Cox, Simon R., Pennell, Craig E., Hall, Graham L., Gauderman, W. James, Brightling, Chris, Wilson, James F., Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O., Timpson, Nicholas J., Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C., Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L., Dudbridge, Frank, Silverman, Edwin K., Strachan, David P., Walters, Robin G., Morris, Andrew P., London, Stephanie J., Cho, Michael H., Wain, Louise V., Hall, Ian P., and Tobin, Martin D.

Published
2023
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5. Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G., Chen, Jing, Packer, Richard, Hall, Robert J., Guyatt, Anna L., Batini, Chiara, Thompson, Rebecca J., Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D., Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A., John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y., Chen, Zhengming, Li, Liming, Wijnant, Sara R. A., Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G., Manichaikul, Ani, Oelsner, Elizabeth C., Rich, Stephen S., Barr, R. Graham, Kerr, Shona M., Vitart, Veronique, Brown, Michael R., Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M., Gharib, Sina A., Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E., Meyers, Deborah A., Bleecker, Eugene R., Gabriel, Stacey B., Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F., Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H., Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L., Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T., Thareja, Gaurav, Albagha, Omar M. E., Suhre, Karsten, Granell, Raquel, Faquih, Tariq O., Hiemstra, Pieter S., Slats, Annelies M., Mullin, Benjamin H., Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T., Wyss, Annah B., Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A., Joshi, Peter K., Timmers, Paul R. H. J., Williams, Alexander T., Free, Robert C., Wang, Xueyang, Morrison, John L., Gilliland, Frank D., Chen, Zhanghua, Wang, Carol A., Foong, Rachel E., Harris, Sarah E., Taylor, Adele, Redmond, Paul, Cook, James P., Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T., Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H., Cox, Simon R., Pennell, Craig E., Hall, Graham L., Gauderman, W. James, Brightling, Chris, Wilson, James F., Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O., Timpson, Nicholas J., Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C., Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L., Dudbridge, Frank, Silverman, Edwin K., Strachan, David P., Walters, Robin G., Morris, Andrew P., London, Stephanie J., Cho, Michael H., Wain, Louise V., Hall, Ian P., and Tobin, Martin D.

Published
2023
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6. An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

Author

Christenson, Stephanie A, van den Berge, Maarten, Faiz, Alen, Inkamp, Kai, Bhakta, Nirav, Bonser, Luke R, Zlock, Lorna T, Barjaktarevic, Igor Z, Barr, R Graham, Bleecker, Eugene R, Boucher, Richard C, Bowler, Russell P, Comellas, Alejandro P, Curtis, Jeffrey L, Han, MeiLan K, Hansel, Nadia N, Hiemstra, Pieter S, Kaner, Robert J, Krishnanm, Jerry A, Martinez, Fernando J, O’Neal, Wanda K, Paine, Robert, Timens, Wim, Wells, J Michael, Spira, Avrum, Erle, David J, and Woodruff, Prescott G

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Chronic Obstructive Pulmonary Disease, Genetics, Tobacco Smoke and Health, Tobacco, Clinical Trials and Supportive Activities, Lung, Aetiology, 2.1 Biological and endogenous factors, Respiratory, Good Health and Well Being, Adrenal Cortex Hormones, Aged, Aged, 80 and over, Bronchi, Drug Resistance, Female, Gene Expression Regulation, Humans, Interleukin-17, Male, Middle Aged, Psoriasis, Pulmonary Disease, Chronic Obstructive, Adaptive immunity, Bioinformatics, COPD, Immunology, Pulmonology, Medical and Health Sciences, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundChronic obstructive pulmonary disease (COPD) is a heterogeneous smoking-related disease characterized by airway obstruction and inflammation. This inflammation may persist even after smoking cessation and responds variably to corticosteroids. Personalizing treatment to biologically similar "molecular phenotypes" may improve therapeutic efficacy in COPD. IL-17A is involved in neutrophilic inflammation and corticosteroid resistance, and thus may be particularly important in a COPD molecular phenotype.MethodsWe generated a gene expression signature of IL-17A response in bronchial airway epithelial brushings from smokers with and without COPD (n = 238), and validated it using data from 2 randomized trials of IL-17 blockade in psoriasis. This IL-17 signature was related to clinical and pathologic characteristics in 2 additional human studies of COPD: (a) SPIROMICS (n = 47), which included former and current smokers with COPD, and (b) GLUCOLD (n = 79), in which COPD participants were randomized to placebo or corticosteroids.ResultsThe IL-17 signature was associated with an inflammatory profile characteristic of an IL-17 response, including increased airway neutrophils and macrophages. In SPIROMICS the signature was associated with increased airway obstruction and functional small airways disease on quantitative chest CT. In GLUCOLD the signature was associated with decreased response to corticosteroids, irrespective of airway eosinophilic or type 2 inflammation.ConclusionThese data suggest that a gene signature of IL-17 airway epithelial response distinguishes a biologically, radiographically, and clinically distinct COPD subgroup that may benefit from personalized therapy.Trial registrationClinicalTrials.gov NCT01969344.FundingPrimary support from the NIH, grants K23HL123778, K12HL11999, U19AI077439, DK072517, U01HL137880, K24HL137013 and R01HL121774 and contracts HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C and HHSN268200900020C.

Published
2019

7. Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

Author

Roukens, Anna H. E., Pothast, Cilia R., König, Marion, Huisman, Wesley, Dalebout, Tim, Tak, Tamar, Azimi, Shohreh, Kruize, Yvonne, Hagedoorn, Renate S., Zlei, Mihaela, Staal, Frank J. T., de Bie, Fenna J., van Dongen, Jacques J. M., Arbous, Sesmu M., Zhang, Jaimie L. H., Verheij, Maaike, Prins, Corine, van der Does, Anne M., Hiemstra, Pieter S., de Vries, Jutte J. C., Janse, Jacqueline J., Roestenberg, Meta, Myeni, Sebenzile K., Kikkert, Marjolein, Yazdanbakhsh, Maria, Heemskerk, Mirjam H. M., Smits, Hermelijn H., and Jochems, Simon P.

Published
2022
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12. Keratin 8 is a scaffolding and regulatory protein of ERAD complexes

Author

Pranke, Iwona Maria, Chevalier, Benoit, Premchandar, Aiswarya, Baatallah, Nesrine, Tomaszewski, Kamil F., Bitam, Sara, Tondelier, Danielle, Golec, Anita, Stolk, Jan, Lukacs, Gergely L., Hiemstra, Pieter S., Dadlez, Michal, Lomas, David A., Irving, James A., Delaunay-Moisan, Agnes, van Anken, Eelco, Hinzpeter, Alexandre, Sermet-Gaudelus, Isabelle, and Edelman, Aleksander

Published
2022
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13. Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation.

Author

Khedoe, P. P. S. J., van Schadewijk, W. A. A. M., Schwiening, M., Ng-Blichfeldt, J. P., Marciniak, S. J., Stolk, J., Gosens, R., and Hiemstra, P. S.

Subjects
UNFOLDED protein response, CHRONIC obstructive pulmonary disease, CIGARETTE smoke, SMOKING, FIBROBLASTS, WNT genes
Abstract

Adequate lung epithelial repair relies on supportive interactions within the epithelial niche, including interactions with WNT-responsive fibroblasts. In fibroblasts from patients with chronic obstructive pulmonary disease (COPD) or upon in vitro cigarette smoke exposure, Wnt/ß-catenin signalling is distorted, which may affect interactions between epithelial cells and fibroblasts resulting in inadequate lung repair. We hypothesized that cigarette smoke (CS), the main risk factor for COPD, interferes with Wnt/ß-catenin signalling in fibroblasts through induction of cellular stress responses, including oxidative- and endoplasmic reticulum (ER) stress, and thereby alters epithelial repair support potential. Therefore, we assessed the effect of CS-exposure and the ER stress inducer Thapsigargin (Tg) on Wnt/ß-catenin signalling activation in MRC-5 fibroblasts, and on their ability to support lung epithelial organoid formation. Exposure of MRC-5 cells for 15 min with 5 AU/mL CS extract (CSE), and subsequent 6 h incubation induced oxidative stress (HMOX1). Whereas stimulation with 100 nM Tg increased markers of both the integrated stress response (ISR - GADD34/PPP1R15A, CHOP) and the unfolded protein response (UPR - XBP1spl, GADD34/PPP1R15A, CHOP and HSPA5/BIP), CSE only induced GADD34/PPP1R15A expression. Strikingly, although treatment of MRC-5 cells with the Wnt activator CHIR99021 upregulated the Wnt/ß-catenin target gene AXIN2, this response was diminished upon CSE or Tg pre-exposure, which was confirmed using a Wnt-reporter. Furthermore, pre-exposure of MRC-5 cells to CSE or Tg, restricted their ability to support organoid formation upon co-culture with murine pulmonary EpCam+ cells in Matrigel at day 14. This restriction was alleviated by pre-treatment with CHIR99021. We conclude that exposure of MRC-5 cells to CSE increases oxidative stress, GADD34/PPP1R15A expression and impairs their ability to support organoid formation. This inhibitory effect may be restored by activating the Wnt/ß-catenin signalling pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein

Author

Guillon, Antoine, Brea‐Diakite, Deborah, Cezard, Adeline, Wacquiez, Alan, Baranek, Thomas, Bourgeais, Jérôme, Picou, Frédéric, Vasseur, Virginie, Meyer, Léa, Chevalier, Christophe, Auvet, Adrien, Carballido, José M, Nadal Desbarats, Lydie, Dingli, Florent, Turtoi, Andrei, Le Gouellec, Audrey, Fauvelle, Florence, Donchet, Amélie, Crépin, Thibaut, Hiemstra, Pieter S, Paget, Christophe, Loew, Damarys, Herault, Olivier, Naffakh, Nadia, Le Goffic, Ronan, and Si‐Tahar, Mustapha

Published
2022
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15. Pulmonary immune responses against SARS-CoV-2 infection: harmful or not?

Author

Guillon, A., Hiemstra, P. S., and Si-Tahar, M.

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Lung diseases -- Development and progression, Immune response -- Health aspects, Infection -- Development and progression, Health care industry
Abstract

Author(s): A. Guillon [sup.1] [sup.2] [sup.3], P. S. Hiemstra [sup.4], M. Si-Tahar [sup.2] [sup.3] Author Affiliations: (1) grid.411167.4, 0000 0004 1765 1600, Intensive Care Unit, Tours University Hospital, , 2 [...]

Published
2020
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17. Asthma–COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease

Author

Christenson, Stephanie A, Steiling, Katrina, van den Berge, Maarten, Hijazi, Kahkeshan, Hiemstra, Pieter S, Postma, Dirkje S, Lenburg, Marc E, Spira, Avrum, and Woodruff, Prescott G

Subjects
Asthma, Lung, Genetics, Chronic Obstructive Pulmonary Disease, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Cohort Studies, Datasets as Topic, Female, Forced Expiratory Volume, Gene Expression Profiling, Humans, Inflammation, Male, Pulmonary Disease, Chronic Obstructive, Transcriptome, chronic obstructive pulmonary disease, gene expression profiling, biological markers, Medical and Health Sciences, Respiratory System
Abstract

RationaleChronic obstructive pulmonary disease (COPD) is a heterogeneous disease and likely includes a subgroup that is biologically comparable to asthma. Studying asthma-associated gene expression changes in COPD could add insight into COPD pathogenesis and reveal biomarkers that predict a favorable response to corticosteroids.ObjectivesTo determine whether asthma-associated gene signatures are increased in COPD and associated with asthma-related features.MethodsWe compared disease-associated airway epithelial gene expression alterations in an asthma cohort (n = 105) and two COPD cohorts (n = 237, 171). The T helper type 2 (Th2) signature (T2S) score, a gene expression metric induced in Th2-high asthma, was evaluated in these COPD cohorts. The T2S score was correlated with asthma-related features and response to corticosteroids in COPD in a randomized, placebo-controlled trial, the Groningen and Leiden Universities study of Corticosteroids in Obstructive Lung Disease (GLUCOLD; n = 89).Measurements and main resultsThe 200 genes most differentially expressed in asthma versus healthy control subjects were enriched among genes associated with more severe airflow obstruction in these COPD cohorts (P < 0.001), suggesting significant gene expression overlap. A higher T2S score was associated with decreased lung function (P < 0.001), but not asthma history, in both COPD cohorts. Higher T2S scores correlated with increased airway wall eosinophil counts (P = 0.003), blood eosinophil percentage (P = 0.03), bronchodilator reversibility (P = 0.01), and improvement in hyperinflation after corticosteroid treatment (P = 0.019) in GLUCOLD.ConclusionsThese data identify airway gene expression alterations that can co-occur in asthma and COPD. The association of the T2S score with increased severity and "asthma-like" features (including a favorable corticosteroid response) in COPD suggests that Th2 inflammation is important in a COPD subset that cannot be identified by clinical history of asthma.

Published
2015

18. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.

Author

Berbée, Jimmy FP, Boon, Mariëtte R, Khedoe, P Padmini SJ, Bartelt, Alexander, Schlein, Christian, Worthmann, Anna, Kooijman, Sander, Hoeke, Geerte, Mol, Isabel M, John, Clara, Jung, Caroline, Vazirpanah, Nadia, Brouwers, Linda PJ, Gordts, Philip LSM, Esko, Jeffrey D, Hiemstra, Pieter S, Havekes, Louis M, Scheja, Ludger, Heeren, Joerg, and Rensen, Patrick CN

Subjects
Liver, Animals, Mice, Knockout, Mice, Hypercholesterolemia, Cholesterol, Triglycerides, Apolipoproteins E, Receptors, Adrenergic, beta-3, Receptors, LDL, Calorimetry, Indirect, Regression Analysis, Reverse Transcriptase Polymerase Chain Reaction, Acclimatization, Female, Male, Atherosclerosis, Adipose Tissue, Brown, Cold Temperature, Knockout, Receptors, Adrenergic, beta-3, LDL, Calorimetry, Indirect, Adipose Tissue, Brown
Abstract

Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role of BAT in plasma cholesterol metabolism and atherosclerosis development remains unclear. Here we show that BAT activation by β3-adrenergic receptor stimulation protects from atherosclerosis in hyperlipidemic APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein metabolism that unlike hyperlipidemic Apoe(-/-) and Ldlr(-/-) mice expresses functional apoE and LDLR. BAT activation increases energy expenditure and decreases plasma triglyceride and cholesterol levels. Mechanistically, we demonstrate that BAT activation enhances the selective uptake of fatty acids from triglyceride-rich lipoproteins into BAT, subsequently accelerating the hepatic clearance of the cholesterol-enriched remnants. These effects depend on a functional hepatic apoE-LDLR clearance pathway as BAT activation in Apoe(-/-) and Ldlr(-/-) mice does not attenuate hypercholesterolaemia and atherosclerosis. We conclude that activation of BAT is a powerful therapeutic avenue to ameliorate hyperlipidaemia and protect from atherosclerosis.

Published
2015

19. Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

Author

Esteve-Codina, Anna, Hofer, Thomas P., Burggraf, Dorothe, Heiss-Neumann, Marion S., Gesierich, Wolfgang, Boland, Anne, Olaso, Robert, Bihoreau, Marie-Therese, Deleuze, Jean-Francois, Moeller, Winfried, Schmid, Otmar, Soler Artigas, María, Renner, Kathrin, Hohlfeld, Jens M., Welte, Tobias, Fuehner, Thomas, Jerrentrup, Lukas, Koczulla, Andreas Rembert, Greulich, Timm, Prasse, Antje, Müller-Quernheim, Joachim, Gupta, Sumit, Brightling, Christopher, Subramanian, Deepak R., Parr, David G., Kolsum, Umme, Gupta, Vandana, Barta, Imre, Döme, Balázs, Strausz, János, Stendardo, Mariarita, Piattella, Marco, Boschetto, Piera, Korzybski, Damian, Gorecka, Dorota, Nowinski, Adam, Dabad, Marc, Fernández-Callejo, Marcos, Endesfelder, David, zu Castell, Wolfgang, Hiemstra, Pieter S., Venge, Per, Noessner, Elfriede, Griebel, Thasso, Heath, Simon, Singh, Dave, Gut, Ivo, and Ziegler-Heitbrock, Loems

Published
2021
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25. Lower airway microbiota in COPD and healthy controls

Author

Tangedal, Solveig, Nielsen, Rune, Aanerud, Marianne, Drengenes, Christine, Husebø, Gunnar R, Lehmann, Sverre, Knudsen, Kristel S, Hiemstra, Pieter S, and Eagan, Tomas ML

Abstract

BackgroundThe lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely altered compared with the microbiota in healthy individuals. Information on how the microbiota is affected by smoking, use of inhaled corticosteroids (ICS) and COPD severity is still scarce.MethodsIn the MicroCOPD Study, participant characteristics were obtained through standardised questionnaires and clinical measurements at a single centre from 2012 to 2015. Protected bronchoalveolar lavage samples from 97 patients with COPD and 97 controls were paired-end sequenced with the Illumina MiSeq System. Data were analysed in QIIME 2 and R.ResultsAlpha-diversity was lower in patients with COPD than controls (Pielou evenness: COPD=0.76, control=0.80, p=0.004; Shannon entropy: COPD=3.98, control=4.34, p=0.01). Beta-diversity differed with smoking only in the COPD cohort (weighted UniFrac: permutational analysis of variance R2=0.04, p=0.03). Nine genera were differentially abundant between COPD and controls. Genera enriched in COPD belonged to the Firmicutesphylum. Pack years were linked to differential abundance of taxa in controls only (ANCOM-BC (Analysis of Compositions of Microbiomes with Bias Correction) log-fold difference/q-values: Haemophilus−0.05/0.048; Lachnoanaerobaculum−0.04/0.03). Oribacteriumwas absent in smoking patients with COPD compared with non-smoking patients (ANCOM-BC log-fold difference/q-values: −1.46/0.03). We found no associations between the microbiota and COPD severity or ICS.ConclusionThe lower airway microbiota is equal in richness in patients with COPD to controls, but less even. Genera from the Firmicutesphylum thrive particularly in COPD airways. Smoking has different effects on diversity and taxonomic abundance in patients with COPD compared with controls. COPD severity and ICS use were not linked to the lower airway microbiota.

Published
2024
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38. The regulation of IL33 following smoking cessation

Author

Faiz, A, primary, Boedijono, F S, additional, Timens, W, additional, Nawijn, M, additional, Hansbro, P M, additional, Mahbub, R, additional, Johansen, M D, additional, Brandsma, C, additional, Heijink, I H, additional, Massip, F, additional, De Biase, M S, additional, Schwarz, R F, additional, Adcock, I M, additional, Chung, K F, additional, Hiemstra, P S, additional, Goulaouic, H, additional, Xing, H, additional, Abdulai, R, additional, De Rinaldis, E, additional, Cunoosamy, D, additional, Harel, S, additional, Lederer, D J, additional, Nivens, C, additional, Kerstjens, H, additional, Hylkema, M, additional, and Van Den Berge, M, additional

Published
2022
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40. Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Author

Mikus, M. S., Kolmert, J., Andersson, L. I., Ostling, J., Knowles, R. G., Gomez, C., Ericsson, M., Thorngren, J. -O., Khoonsari, P. E., Dahlen, B., Kupczyk, M., de Meulder, B., Auffray, C., Bakke, P. S., Beghe, Bianca, Bel, E. H., Caruso, M., Chanez, P., Chawes, B., Fowler, S. J., Gaga, M., Geiser, T., Gjomarkaj, M., Horvath, I., Howarth, P. H., Johnston, S. L., Joos, G., Krug, N., Montuschi, P., Musial, J., Nizankowska-Mogilnicka, E., Olsson, H. K., Papi, A., Rabe, K. F., Sandstrom, T., Shaw, D. E., Siafakas, N. M., Uhlen, M., Riley, J. H., Bates, S., Middelveld, R. J. M., Wheelock, C. E., Chung, K. F., Adcock, I. M., Sterk, P. J., Djukanovic, R., Nilsson, P., Dahlen, S. -E., James, A., Ahmed, H., Balgoma, D., Bansal, A. T., Baribaud, F., Bigler, J., Billing, B., Bisgaard, H., Boedigheimer, M. J., Bonnelykke, K., Brandsma, J., Brinkman, P., Bucchioni, E., Burg, D., Bush, A., Chaiboonchoe, A., Checa, T., Compton, C. H., Corfield, J., Cunoosamy, D., D'Amico, A., Emma, R., Erpenbeck, V. J., Erzen, D., Fichtner, K., Fitch, N., Fleming, L. J., Formaggio, E., Frey, U., Gahlemann, M., Goss, V., Guo, Y. -K., Hashimoto, S., Haughney, J., Hedlin, G., Hekking, P. -P. W., Higenbottam, T., Hohlfeld, J. M., Holweg, C. T. J., Knox, A. J., Konradsen, J., Lazarinis, N., Lefaudeux, D., Li, T., Loza, M. J., Lutter, R., Manta, A., Masefield, S., Matthews, J. G., Mazein, A., Meiser, A., Miralpeix, M., Mores, N., Murray, C. S., Myles, D., Naz, S., Nordlund, B., Pahus, L., Pandis, I., Pavlidis, S., Postle, A., Powel, P., Rao, N., Reinke, S., Roberts, A., Roberts, G., Rowe, A., Schofield, J. P. R., Seibold, W., Selby, A., Sigmund, R., Singer, F., Sjodin, M., Skipp, P. J., Sousa, A. R., Sun, K., Thornton, B., Uddin, M., van Aalderen, W. M., van Geest, M., Vestbo, J., Vissing, N. H., Wagener, A. H., Wagers, S. S., Weiszhart, Z., Wheelock, A., Wilson, S. J., Yasinska, V., Brusselle, G. G., Campbell, D. A., Contoli, M., Damm, K., de Rudder, I., Delin, I., Devautour, C., Duplaga, M., Eduards, M., Ek, A., Ekstrom, T., Figiel, E., Gaber, F., Gauw, S., Gawlewicz-Mroczka, A., Gerding, D., Haque, S., Hewitt, L., Hiemstra, P. S., Holgate, S. T., Holloway, J., Kania, A., Kanniess, F., Karlsson, O., Kips, J. C., Kumlin, M., Lantz, A. -S., Magnussen, H., Mallia, P., Martling, I., Meziane, L., Oikonomidou, E., Olsson, M., Pace, E., Papadopouli, E., Papadopoulos, N., Plataki, M., Profita, M., Reinius, L. E., Richter, K., Robinson, D. S., Romagnoli, M., Samara, K., Schelfhout, V., Skedinger, M., Stamataki, E., ten Brinke, A., Vachier, I., Wallen-Nielsen, E., van Veen, I., Weersink, E., Zervas, E., and Ziolkowska-Graca, B.

Subjects
Blood Proteins, Humans, Inflammation, Proteomics, Severity of Illness Index, Steroids, Asthma, Quality of Life
Published
2022

42. The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach

Author

Ditz, B., primary, Boekhoudt, J., additional, Couto, N., additional, Brandsma, C. A., additional, Hiemstra, P. S., additional, Tew, G. W., additional, Neighbors, M., additional, Grimbaldeston, M. A., additional, Timens, W., additional, Kerstjens, H. A. M., additional, Rossen, J. W. A., additional, Guryev, V., additional, van den Berge, M., additional, and Faiz, A., additional

Published
2022
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44. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author

Loth, Daan W, Artigas, María Soler, Gharib, Sina A, Wain, Louise V, Franceschini, Nora, Koch, Beate, Pottinger, Tess D, Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P, James, Alan L, Huffman, Jennifer E, Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J, Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Kähönen, Mika, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M, de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K, Fall, Tove, Viñuela, Ana, Launer, Lenore J, Loehr, Laura R, Fornage, Myriam, Li, Guo, Wilk, Jemma B, Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B, North, Kari E, Rudnicka, Alicja R, Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F, Hastie, Nicholas D, Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A, Pietiläinen, Kirsi H, Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G, Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M, Wojczynski, Mary, Pouta, Anneli, Johansson, Åsa, Wild, Sarah H, Ingelsson, Erik, Rivadeneira, Fernando, Völzke, Henry, Hysi, Pirro G, Eiriksdottir, Gudny, Morrison, Alanna C, Rotter, Jerome I, Gao, Wei, Postma, Dirkje S, White, Wendy B, Rich, Stephen S, Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J, Psaty, Bruce M, Lohman, Kurt, Burchard, Esteban G, Uitterlinden, André G, Garcia, Melissa, Joubert, Bonnie R, McArdle, Wendy L, Musk, A Bill, Hansel, Nadia, Heckbert, Susan R, Zgaga, Lina, van Meurs, Joyce B J, Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L, Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T, Ripatti, Samuli, Scott, Rodney J, Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C, Starr, John M, Wijmenga, Cisca, Minster, Ryan L, Lederer, David J, Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P, Gläser, Sven, Hammond, Christopher J, Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B, Gudnason, Vilmundur, Hancock, Dana B, Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F, Wjst, Matthias, Kim, Woo Jin, Porteous, David J, Scotland, Generation, Smith, Blair H, Viljanen, Anne, Heliövaara, Markku, Attia, John R, Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H, Teumer, Alexander, Spector, Timothy D, Melén, Erik, Peters, Marjolein J, Lange, Leslie A, Barr, R Graham, Bracke, Ken R, Verhamme, Fien M, Sung, Joohon, Hiemstra, Pieter S, Cassano, Patricia A, Sood, Akshay, Hayward, Caroline, Dupuis, Josée, Hall, Ian P, Brusselle, Guy G, Tobin, Martin D, and London, Stephanie J

Published
2014
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