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1. Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study

Author

Karamchandani, Kunal, Nasa, Prashant, Jarzebowski, Mary, Brewster, David J., De Jong, Audrey, Bauer, Philippe R., Berkow, Lauren, Brown, III, Calvin A., Cabrini, Luca, Casey, Jonathan, Cook, Tim, Divatia, Jigeeshu Vasishtha, Duggan, Laura V., Ellard, Louise, Ergan, Begum, Jonsson Fagerlund, Malin, Gatward, Jonathan, Greif, Robert, Higgs, Andy, Jaber, Samir, Janz, David, Joffe, Aaron M., Jung, Boris, Kovacs, George, Kwizera, Arthur, Laffey, John G., Lascarrou, Jean-Baptiste, Law, J. Adam, Marshall, Stuart, McGrath, Brendan A., Mosier, Jarrod M., Perin, Daniel, Roca, Oriol, Rollé, Amélie, Russotto, Vincenzo, Sakles, John C., Shrestha, Gentle S., Smischney, Nathan J., Sorbello, Massimiliano, Tung, Avery, Jabaley, Craig S., and Myatra, Sheila Nainan

Published
2024
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3. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study

Author

Anstey, Matthew, Colica, Sandra, Brewster, David, Simpson, Shannon, Regli, Adrian, O'Grady, Ross, Litton, Edward, Ferrier, Janet, Bartholdy, Roland, Tabah, Alexis, Bowen, David, Rowley, Rebecca, Gatward, Jonathan, Alonso, Julio, Varkey, Sneha, Palaniswamy, Vijayanand, Chimunda, Timothy, Reza, Syed T., Hossain, Mozaffer, Islam, Motiul, Hamid, Tarikul, Parotto, Matteo, Ajami, Samareh, Steel, Andrew, Del Sorbo, Lorenzo, Goffi, Alberto, Randall, Ian, Adhikari, Neill K.J., Mehesry, Tasneem H., Vera, Maria M., Bugedo, Guillermo, Labarca, Gonzalo, Silva, Monica, Ma, Wuhua, Li, Yongxing, Wu, Jiayan, Wu, Lun, Radivojević, Renata Curić, Matas, Marijana, Ivančan, Višnja, Pavlek, Mario, Mihaljević, Slobodan, Jumić, Aleksandra, Moguš, Mate, Tucić, Iva, Michalek, Pavel, Flaksa, Marek, Aguirre-Bermeo, Hernan, Tirape-Castro, Hugo, García Aguilera, Maria F., Montenegro, Diana Alvarez, Tutillo, Diego Morocho, Tutillo León, Jose A., Winiszewski, Hadrien, Piton, Gael, Aissaoui, Nadia, Augy, Jean-Loup, Champigneulle, Benoit, Zlotnik, Diane, Muller, Grégoire, Jacquier, Sophie, Hraiech, Sami, Guervilly, Christophe, Plantefeve, Gaetan, Contou, Damien, Ricard, Jean Damien, Besset, Sebastien, Colin, Gwenhael, Pouplet, Caroline, Mirouse, Adrien, Azoulay, Elie, Boissier, Florence, Frat, Jean-Pierre, Mercier, Emmanuelle, Salmon-Gandonnière, Charlotte, Lascarrou, Jean-Baptiste, Martin, Maelle, Ferre, Alexis, Legriel, Stephane, Bruel, Cedric, Philippard, Francois, Zarka, Jonathan, Chemouni, Frank, Hamzaoui, Olfa, Sztrymf, Benjamin, Brunin, Yannick, Pili-Floury, Sébastien, Constantin, Jean-Michel, Godet, Thomas, Maraffi, Tommaso, Dessap, Armand Mekontso, Jozwiak, Mathieu, Marin, Nathalie, Guitton, Christophe, Chudeau, Nicolas, Gros, Alexandre, Boyer, Alexandre, Papandreou, Eleni, Petsiou, Athanasia, Papanikolaou, Metaxia, Kyparissi, Aikaterini, Tileli, Maria, Makris, Alexandros, Tsiftsis, Dimitrios, El-Fellah, Nadia, Karametos, Ilias, Nakou, Evi, Chalkias, Athanasios, Arnaoutoglou, Eleni, Katsoulis, Panagiotis, Pouriki, Sofia, Vagdatli, Kyriaki, Dimitropoulou, Aikaterini, Kothekar, Amol, Baliga, Nishanth, Korula, Sara V., Philip, Sam, Singh, Lalit, Agrawal, Nipun, Jeswani, Deepak, Jeswani, Deepti, Jha, Simant, Singh, Nitesh, Bhattacharyya, Mahuya, Das, Amit, Kuragayala, Swarna D., Kesavarapu, Subba R., Shah, Bhagyesh, Kaushik, Shuchi, Sunil, Nilu, Gnanadurai, Kingsly, Singh, Atul K., Singh, Dinesh K., Khunteta, Sudhir, Gupta, Kulbhusahn, Sanyal, Rhik, Midya, Abhirup, Tyagi, Vijay N., Bendre, Prashant, Prashant, Kumar, Chaurasia, Satish, Mishra, Prasanna, Dash, Sampat, Sundrani, Omprakash, Lalwani, Jaya, Jain, Nikhilesh, Agrawal, Kehari, Ray, Banambar, Meher, Ranjan, Saravanabavan, Lakshmikanthcharan, Munusamy, Satheesh, Gupta, Manish, Ahmad, Meraj, Gopalakrishna, Kadarapura N., Suparna, Bharadwaj, Surath, Manimala R., Munta, Kartik, Jagiasi, Bharat, Srivastava, Anand, Sahu, Samir, Mrinal, Sircar, Kumar, Singh Sujeet, Shah, Mehul, Patel, Mayur, Bamane, Shrirang, Narkhede, Amit, Chawla, Rajesh, Chawla, Aakanksha, Maheshwarappa, Harish Mallapura, Manjunath, Ramya Ballekatte, Rahmani, Lua, Laffey, John G., Rona, Roberto, Benini, Annalisa, Russotto, Vincenzo, Rundo, Annalisa, Luzi, Annalisa, Esposito, Clelia, Nespoli, Moana R., Pradella, Andrea, Lungu, Ramona, Baccari, Laura, Chiumiento, Fernando, Mariano, Karim, Cotoia, Antonella, De Rosa, Silvia, Boni, Elisa, Palmese, Salvatore, Gammaldi, Renato, Spadaro, Savino, Santoro, Lida, Cracchiolo, Andrea N., Palma, Daniela M., Pinciroli, Riccardo, Giovannini, Ilaria, Calamai, Italo, Spina, Rosario, Cappellini, Iacopo, Tutino, Lorenzo, Bellissima, Agrippino, Maugeri, Jessica G., Riva, Ivano, Fabretti, Fabrizio, Brazzi, Luca, Sales, Gabriele, Montrucchio, Giorgia, Orsello, Alberto, Costamagna, Andrea, Canavosio, Federico G., Pelagalli, Lorella, Marcelli, Maria E., Cortegiani, Andrea, Tramarin, Jacopo, Musso, Stefania, Tarantino, Stefano, Di Giacinto, Ida, Licciardi, Anna L., Montini, Luca, De Pascale, Gennaro, Giacomucci, Angelo, Russo, Pierpaolo, Longhini, Federico, Garofalo, Eugenio, Ferluga, Massimo, Moro, Valeria, Cascella, Marco, Di Caprio, Barbara, Di Fenza, Raffaele, Nespoli, Francesca, Bassini, Ospedale E., Muttini, Stefano, Pezzi, Angelo, Elhadi, Muhammed, Ghula, Mohamed, Ahmed, Hazem Abdelkarem, Khaled, Ala, Elhadi, Ahmed, Alhadi, Abdulmueti, Mazlan, Mohd Z., Wan Hassan, Wan Mohd N., Hasan, Shahnaz, Jamaluddin, Muhamad F.H., Samat, Noryani Mohd, Ismail, Muhamad A., Alias, Anita, Hwa, Ngu Pei, Irtiza, Ismail Nahla, Khalidah, Hapiz, Kiok, Lee Chew, Nordin, Norbaniza Mohd, Wan Ismail, Wan N., Ali, Mohd N., Sánchez-Hurtado, Luis, Toledo-Salinas, Otoniel, Landaverde, Antonio, Sosa, Miguel A., Gonzalez, Mayra Martinez, Lopez Nava, Claudia L., San Juan Roman, Nandyelly, Gonzalez, Maria, Espinoza, Missael, González, Daira, Flores, Fernando, Pantoja Leal, Jesus N., Loza Gallardo, Luis R., Young, Paul, Mistry, Ravi, Browne, Alexander, Crone, Petra, Chandwani, Juhi, Hossein, Sazzad, Koul, Salman S., Aman, Rubina, Ali, Syed M., Akhtar, Shazia N., Jankowski, Milosz, Bielanski, Piotr, Mudyna, Wojciech, Franczyk, Pawel, Galkin, Piotr, Skowronski, Lukasz, Gaszynski, Tomasz, Piegat, Mariusz, Catorze, Nuno, Pinto, Marcia, Leonor, Tiago, Fernandes, Marco, Campos, Patricia, Aragão, Irene, Costa, Paulo F., Franco, Daniela G., Basto, Marta, Nogueira, Carla, Cunha, Rui P., Costa, Vasco, Lomivorotov, Vladimir, Nikitenko, Artem, Belsky, Vladislav, Furman, Mikhail, Magomedov, Marat, Baturova, Vera, Karelov, Alexey, Marova, Nadezhda, Almekhlafi, Ghaleb, Alghamdi, Adnan, Maseda, Emilio, Suarez de la Rica, Alejandro, Gonzalez, Jesus Flores, Ruiz, Miryam Pérez, Roca, Oriol, Santafe, Manel, Fernandez, Gemma Goma, Escudero-Acha, Patricia, González-Castro, Alejandro, Agvald-Öhman, Christina, Broman, Lina, Spangfors, Martin, Hannesdottir, Katrin, Persson, Elin, Rosell, Jon, Sperber, Jesper, Ohlsson, Annika, Von Seth, Magnus, Pedrotti, Niccolò, Wahlstrom, Carl, Meirik, Maria, Bandert, Anna, Krog, Ditte, Kuo, Lu-Cheng, Shin, Ming-Hann, Chien, Jung-Yien, Ku, Shih-Chi, Ruan, Sheng-Yuan, Huang, Chun-Kai, Yeh, Yu-Chang, Chao, Anne, Wang, Kuo-Chuan, Chiu, Ching-Tang, Lee, Chien-Chang, Chou, Nai-Kuan, Szakmany, Tamas, Jones, Benjamin, Jones, Laura, Della Torre, Valentina, Sinah, Ayush, Quayle, Alice, Cheetham, Olivia, Syed, Yadullah, Mensah, Kwabena, Edmunds, Christopher, Kaye, Callum T., Bauer, Philippe R., Odeyemi, Yewande E., Nates, Joseph, Laserna, Andres, Mosier, Jarrod, Hypes, Cameron, Gottesman, Eric, Mastroianni, Fiore, Fein, Daniel G., Zhao, Dawn, Fonseca Fuentes, Xavier E., Gallo de Moraes, Alice, Sandefur, Benjamin J., Khan, Akram, Matos, Dubier, Kaufman, David A., Lehr, Andrew, Bigatello, Luca, Bonney, Iwona, Lascarrou, Jean Baptiste, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Szułdrzyński, Konstanty, Camporota, Luigi, Putensen, Christian, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Grasselli, Giacomo, Valsecchi, Maria G., Fumagalli, Roberto, Foti, Giuseppe, Caironi, Pietro, Bellani, Giacomo, and Myatra, Sheila N.

Published
2023
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6. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study

Author

Russotto, Vincenzo, primary, Lascarrou, Jean Baptiste, additional, Tassistro, Elena, additional, Parotto, Matteo, additional, Antolini, Laura, additional, Bauer, Philippe, additional, Szułdrzyński, Konstanty, additional, Camporota, Luigi, additional, Putensen, Christian, additional, Pelosi, Paolo, additional, Sorbello, Massimiliano, additional, Higgs, Andy, additional, Greif, Robert, additional, Grasselli, Giacomo, additional, Valsecchi, Maria G., additional, Fumagalli, Roberto, additional, Foti, Giuseppe, additional, Caironi, Pietro, additional, Bellani, Giacomo, additional, Laffey, John G., additional, and Myatra, Sheila N., additional

Published
2023
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8. Peri-intubation Cardiovascular Collapse in Patients Who Are Critically Ill: Insights from the INTUBE Study

Author

Russotto, Vincenzo, primary, Tassistro, Elena, additional, Myatra, Sheila N., additional, Parotto, Matteo, additional, Antolini, Laura, additional, Bauer, Philippe, additional, Lascarrou, Jean Baptiste, additional, Szułdrzyński, Konstanty, additional, Camporota, Luigi, additional, Putensen, Christian, additional, Pelosi, Paolo, additional, Sorbello, Massimiliano, additional, Higgs, Andy, additional, Greif, Robert, additional, Pesenti, Antonio, additional, Valsecchi, Maria Grazia, additional, Fumagalli, Roberto, additional, Foti, Giuseppe, additional, Bellani, Giacomo, additional, and Laffey, John G., additional

Published
2022
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10. Peri-intubation Cardiovascular Collapse in Critically Ill Patients: Insights from the INTUBE Study

Author

Russotto, V, Tassistro, E, Myatra, S, Parotto, M, Antolini, L, Bauer, P, Lascarrou, J, Szułdrzyński, K, Camporota, L, Putensen, C, Pelosi, P, Sorbello, M, Higgs, A, Greif, R, Pesenti, A, Valsecchi, M, Fumagalli, R, Foti, G, Bellani, G, Laffey, J, Russotto, Vincenzo, Tassistro, Elena, Myatra, Sheila N, Parotto, Matteo, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szułdrzyński, Konstanty, Camporota, Luigi, Putensen, Christian, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Pesenti, Antonio, Valsecchi, Maria Grazia, Fumagalli, Roberto, Foti, Giuseppe, Bellani, Giacomo, Laffey, John G, Russotto, V, Tassistro, E, Myatra, S, Parotto, M, Antolini, L, Bauer, P, Lascarrou, J, Szułdrzyński, K, Camporota, L, Putensen, C, Pelosi, P, Sorbello, M, Higgs, A, Greif, R, Pesenti, A, Valsecchi, M, Fumagalli, R, Foti, G, Bellani, G, Laffey, J, Russotto, Vincenzo, Tassistro, Elena, Myatra, Sheila N, Parotto, Matteo, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szułdrzyński, Konstanty, Camporota, Luigi, Putensen, Christian, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Pesenti, Antonio, Valsecchi, Maria Grazia, Fumagalli, Roberto, Foti, Giuseppe, Bellani, Giacomo, and Laffey, John G

Abstract

Rationale: Cardiovascular instability/collapse is a common peri-intubation event in patients who are critically ill. Objectives: To identify potentially modifiable variables associated with peri-intubation cardiovascular instability/collapse (i.e., systolic arterial pressure <65 mm Hg [once] or [removed]30 minutes; new/increased vasopressor requirement; fluid bolus >15 ml/kg, or cardiac arrest). Methods: INTUBE (International Observational Study to Understand the Impact and Best Practices of Airway Management In Critically Ill Patients) was a multicenter prospective cohort study of patients who were critically ill and undergoing tracheal intubation in a convenience sample of 197 sites from 29 countries across five continents from October 1, 2018, to July 31, 2019. Measurements and Main Results: A total of 2,760 patients were included in this analysis. Peri-intubation cardiovascular instability/ collapse occurred in 1,199 out of 2,760 patients (43.4%). Variables associated with this event were older age (odds ratio [OR], 1.02; 95% confidence interval [CI], 1.02-1.03), higher heart rate (OR, 1.008; 95% CI, 1.004-1.012), lower systolic blood pressure (OR, 0.98; 95% CI, 0.98-0.99), lower oxygen saturation as measured by pulse oximetry/ FIO2 before induction (OR, 0.998; 95% CI, 0.997-0.999), and the use of propofol as an induction agent (OR, 1.28; 95% CI, 1.05-1.57). Patients with peri-intubation cardiovascular instability/collapse were at a higher risk of ICU mortality with an adjusted OR of 2.47 (95% CI, 1.72-3.55), P < 0.001. The inverse probability of treatment weighting method identified the use of propofol as the only factor independently associated with cardiovascular instability/collapse (OR, 1.23; 95% CI, 1.02-1.49). When administered before induction, vasopressors (OR, 1.33; 95% CI, 0.84-2.11) or fluid boluses (OR, 1.17; 95% CI, 0.96-1.44) did not reduce the incidence of cardiovascular instability/collapse. Conclusions: Peri-intubation cardiovascular i

Published
2022

11. Peri-intubation Cardiovascular Collapse in Critically Ill Patients: Insights from the INTUBE Study

Author

Russotto, Vincenzo, Tassistro, Elena, Myatra, Sheila N, Parotto, Matteo, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szułdrzyński, Konstanty, Camporota, Luigi, Putensen, Christian, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Pesenti, Antonio, Valsecchi, Maria Grazia, Fumagalli, Roberto, Foti, Giuseppe, Bellani, Giacomo, Laffey, John G., Russotto, V, Tassistro, E, Myatra, S, Parotto, M, Antolini, L, Bauer, P, Lascarrou, J, Szułdrzyński, K, Camporota, L, Putensen, C, Pelosi, P, Sorbello, M, Higgs, A, Greif, R, Pesenti, A, Valsecchi, M, Fumagalli, R, Foti, G, Bellani, G, and Laffey, J

Subjects
airway management, cardiovascular collapse, Intubation
Abstract

Rationale: Cardiovascular instability/collapse is a common peri-intubation event in patients who are critically ill. Objectives: To identify potentially modifiable variables associated with peri-intubation cardiovascular instability/collapse (i.e., systolic arterial pressure 15 ml/kg, or cardiac arrest). Methods: INTUBE (International Observational Study to Understand the Impact and Best Practices of Airway Management In Critically Ill Patients) was a multicenter prospective cohort study of patients who were critically ill and undergoing tracheal intubation in a convenience sample of 197 sites from 29 countries across five continents from October 1, 2018, to July 31, 2019. Measurements and Main Results: A total of 2,760 patients were included in this analysis. Peri-intubation cardiovascular instability/ collapse occurred in 1,199 out of 2,760 patients (43.4%). Variables associated with this event were older age (odds ratio [OR], 1.02; 95% confidence interval [CI], 1.02-1.03), higher heart rate (OR, 1.008; 95% CI, 1.004-1.012), lower systolic blood pressure (OR, 0.98; 95% CI, 0.98-0.99), lower oxygen saturation as measured by pulse oximetry/ FIO2 before induction (OR, 0.998; 95% CI, 0.997-0.999), and the use of propofol as an induction agent (OR, 1.28; 95% CI, 1.05-1.57). Patients with peri-intubation cardiovascular instability/collapse were at a higher risk of ICU mortality with an adjusted OR of 2.47 (95% CI, 1.72-3.55), P < 0.001. The inverse probability of treatment weighting method identified the use of propofol as the only factor independently associated with cardiovascular instability/collapse (OR, 1.23; 95% CI, 1.02-1.49). When administered before induction, vasopressors (OR, 1.33; 95% CI, 0.84-2.11) or fluid boluses (OR, 1.17; 95% CI, 0.96-1.44) did not reduce the incidence of cardiovascular instability/collapse. Conclusions: Peri-intubation cardiovascular instability/collapse was associated with an increased risk of both ICU and 28-day mortality. The use of propofol for induction was identified as a modifiable intervention significantly associated with cardiovascular instability/collapse.

Published
2022

12. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries

Author

Russotto, Vincenzo, Myatra, Sheila Nainan, Laffey, John G, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szuldrzynski, Konstanty, Camporota, Luigi, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Putensen, Christian, Agvald-Öhman, Christina, Chalkias, Athanasio, Bokums, Kristap, Brewster, David, Rossi, Emanuela, Fumagalli, Roberto, Pesenti, Antonio, Foti, Giuseppe, Bellani, Giacomo, Montini, Luca, Montini, Luca (ORCID:0000-0003-4602-5134), Russotto, Vincenzo, Myatra, Sheila Nainan, Laffey, John G, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szuldrzynski, Konstanty, Camporota, Luigi, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Putensen, Christian, Agvald-Öhman, Christina, Chalkias, Athanasio, Bokums, Kristap, Brewster, David, Rossi, Emanuela, Fumagalli, Roberto, Pesenti, Antonio, Foti, Giuseppe, Bellani, Giacomo, Montini, Luca, and Montini, Luca (ORCID:0000-0003-4602-5134)

Abstract

Key PointsQuestionAmong critically ill patients undergoing tracheal intubation worldwide, how common are major adverse events during the peri-intubation period? FindingsIn this prospective observational study that included 2964 patients from 197 sites across 29 countries from October 2018 to July 2019, at least one major clinical event occurred after intubation in 45.2% of patients, including cardiovascular instability in 42.6%, severe hypoxemia in 9.3%, and cardiac arrest in 3.1%. MeaningAmong an international sample of critically ill patients undergoing tracheal intubation, major cardiopulmonary events occurred frequently.ImportanceTracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events. ObjectiveTo evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients. Design, Setting, and ParticipantsThe International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients (INTUBE) study was an international, multicenter, prospective cohort study involving consecutive critically ill patients undergoing tracheal intubation in the intensive care units (ICUs), emergency departments, and wards, from October 1, 2018, to July 31, 2019 (August 28, 2019, was the final follow-up) in a convenience sample of 197 sites from 29 countries across 5 continents. ExposuresTracheal intubation. Main Outcomes and MeasuresThe primary outcome was the incidence of major adverse peri-intubation events defined as at least 1 of the following events occurring within 30 minutes from the start of the intubation procedure: cardiovascular instability (either: systolic pressure <65 mm Hg at least once, <90 mm Hg for >30 minutes, new or increase need of vasopressors or fluid bolus >15 mL/kg), severe hypoxemia (peripheral oxygen saturation

Published
2021

13. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries

Author

Russotto, V, Myatra, S, Laffey, J, Tassistro, E, Antolini, L, Bauer, P, Lascarrou, J, Szuldrzynski, K, Camporota, L, Pelosi, P, Sorbello, M, Higgs, A, Greif, R, Putensen, C, Agvald-Öhman, C, Chalkias, A, Bokums, K, Brewster, D, Rossi, E, Fumagalli, R, Pesenti, A, Foti, G, Bellani, G, Russotto, Vincenzo, Myatra, Sheila Nainan, Laffey, John G, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szuldrzynski, Konstanty, Camporota, Luigi, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Putensen, Christian, Agvald-Öhman, Christina, Chalkias, Athanasios, Bokums, Kristaps, Brewster, David, Rossi, Emanuela, Fumagalli, Roberto, Pesenti, Antonio, Foti, Giuseppe, Bellani, Giacomo, Russotto, V, Myatra, S, Laffey, J, Tassistro, E, Antolini, L, Bauer, P, Lascarrou, J, Szuldrzynski, K, Camporota, L, Pelosi, P, Sorbello, M, Higgs, A, Greif, R, Putensen, C, Agvald-Öhman, C, Chalkias, A, Bokums, K, Brewster, D, Rossi, E, Fumagalli, R, Pesenti, A, Foti, G, Bellani, G, Russotto, Vincenzo, Myatra, Sheila Nainan, Laffey, John G, Tassistro, Elena, Antolini, Laura, Bauer, Philippe, Lascarrou, Jean Baptiste, Szuldrzynski, Konstanty, Camporota, Luigi, Pelosi, Paolo, Sorbello, Massimiliano, Higgs, Andy, Greif, Robert, Putensen, Christian, Agvald-Öhman, Christina, Chalkias, Athanasios, Bokums, Kristaps, Brewster, David, Rossi, Emanuela, Fumagalli, Roberto, Pesenti, Antonio, Foti, Giuseppe, and Bellani, Giacomo

Abstract

Importance: Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events. Objective: To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients. Design, Setting, and Participants: The International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients (INTUBE) study was an international, multicenter, prospective cohort study involving consecutive critically ill patients undergoing tracheal intubation in the intensive care units (ICUs), emergency departments, and wards, from October 1, 2018, to July 31, 2019 (August 28, 2019, was the final follow-up) in a convenience sample of 197 sites from 29 countries across 5 continents. Exposures: Tracheal intubation. Main Outcomes and Measures: The primary outcome was the incidence of major adverse peri-intubation events defined as at least 1 of the following events occurring within 30 minutes from the start of the intubation procedure: cardiovascular instability (either: systolic pressure <65 mm Hg at least once, <90 mm Hg for >30 minutes, new or increase need of vasopressors or fluid bolus >15 mL/kg), severe hypoxemia (peripheral oxygen saturation <80%) or cardiac arrest. The secondary outcomes included intensive care unit mortality. Results: Of 3659 patients screened, 2964 (median age, 63 years; interquartile range [IQR], 49-74 years; 62.6% men) from 197 sites across 5 continents were included. The main reason for intubation was respiratory failure in 52.3% of patients, followed by neurological impairment in 30.5%, and cardiovascular instability in 9.4%. Primary outcome data were available for all patients. Among the study patients, 45.2% experienced at least 1 major adverse peri-intubation event. The predominant event was cardiovascular instability, ob

Published
2021

15. Contributors

Author

Ahmad, Imran, Alexander, Ronda E., Artime, Carlos A., Aziz, Michael F., Baker, Paul A., Ball, Christine M., Basañez, Irving, Beaman, Shawn T., Behringer, Elizabeth C., Bello, Jacqueline A., Benumof, Jonathan L., Berkow, Lauren C., Brambrink, Ansgar M., Braude, Darren Alan, Cameron, Staci D., Cattano, Davide, Cavallone, Laura F., Chi, T. Linda, Chrimes, Nicholas, Cohen, Edmond, Cohen, Neal H., Cook, Tim M., Cooper, Richard M., Diemunsch, Pierre, Doyle, D. John, DuCanto, James, Duggan, Laura V., Dutton, Richard P., El-Boghdadly, Kariem, Ellard, Louise, Feinleib, Jessica L., Ferson, David Z., Foley, Lorraine J., Gaitini, Luis, Galgon, Richard E., Gibbs, Michael Alfred, MME, Robert Greif, Grissom, Thomas E., Guzman-Reyes, Sara, Hagberg, Carin A., Hayanga, Heather K., MD, Thomas Heidegger, Higgs, Andy, Hodge, Caleb B., Hung, Orlando, Ibrahim, Haitham, Jagannathan, Narasimhan, Jain, Ranu R., Johnson, Liane B., Kastner, Mark, Jr., Jeffrey P. Keck, Jr., P. Allan Klock, Knight, Joshua B., Kovacs, George, Kristensen, Michael Seltz, Langeron, Olivier, Lee, Sarah A., Lindsay, Helen A., J. Mark, Lynette, Mark, Nathan D., Marshall, Stuart D., Mathew, Reeba, Matioc, Adrian, McClelland, Andrew C., III, Joseph H. McIsaac, McNarry, Alistair F., Mirsky, David M., Mohamed, Basma, Moon, Tiffany Sun, Mort, Thomas C., Mosier, Jarrod M., Nabecker, Sabine, Nagrebetsky, Alexander, Naruse, Robert, Nekhendzy, Vladimir, O’Grady, Kevin F., Ogunnaike, Babatunde, Oh, Matthew W., Olivar, Hernando P., Osborn, Irene P., O’Sullivan, Ellen, Palaniappan, Dhamodaran, Parotto, Matteo, MBBS, Anil Patel, Patel, Bela, Piacentini, Alberto G.G., Poole, Oliver J., Potnuru, Paul, Quinlan, Joseph J., Ramirez-Chapman, Ana Lisa, Roberts, Fiona, Rosenblatt, William H., Ross, Christopher, Roy, Soham, Samet, Ron E., Schiff, Jan-Henrik, Schmitz, Bettina U., Sharar, Sam R., Sharofi, Saimir, Shifteh, Keivan, Soliman, Maged, Sparrow, Kathryn, Sridhar, Srikanth, Steuerwald, Michael Thomas, Straker, Tracey, Subramanya, Sriharsha, Suresh, Maya S., Teoh, Wendy H., Urdaneta, Felipe, Vaida, Sonia, Jr., Manuel C. Vallejo, Vanga, Naveen, Walker, Kathryn K., Walther, Andreas, Warner, Mark T., Wilkinson, David J., Wilson, William C., Wong, David T., Zakowski, Mark, and Zdravkovic, Marko

Published
2023
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17. Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID ‐19 adult patient group

Author

Brewster, David J, primary, Chrimes, Nicholas, additional, Do, Thy BT, additional, Fraser, Kirstin, additional, Groombridge, Christopher J, additional, Higgs, Andy, additional, Humar, Matthew J, additional, Leeuwenburg, Timothy J, additional, McGloughlin, Steven, additional, Newman, Fiona G, additional, Nickson, Chris P, additional, Rehak, Adam, additional, Vokes, David, additional, and Gatward, Jonathan J, additional

Published
2020
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21. Contributors

Author

Alexander, Ronda E., Anderson, Jennifer, Artime, Carlos A., Asselin, Mathieu, Aziz, Michael F., Baker, Paul A., Ball, Christine M., Basañez, Irving, Beaman, Shawn T., Behringer, Elizabeth C., Bello, Jacqueline A., Benumof, Jonathan L., Berkow, Lauren C., Biro, Peter, Boggs, S.D., Brambrink, Ansgar M., Braude, Darren A., Cameron, Staci D., Cattano, Davide, Cavallone, Laura F., Chi, T. Linda, Cohen, Edmond, Cohen, Neal H., Coleman, Lee, Cook, Tim M., Cooper, Richard M., Deransy, Romain, Diemunsch, Pierre A., Dorsey, David P., Doyle, D. John, DuCanto, James, Dutton, Richard P., Feinleib, Jessica Lunaas, Ferrario, Lara, Ferson, David Z., Foley, Lorraine J., Frass, Michael, Gaitini, Luis, Gibbs, Michael A., Gil, Katherine S.L., Gold, Julian A., Greif, Robert Tino, Grissom, Thomas E., Guzman-Reyes, Sara, Hagberg, Carin A., Hammer, Gregory B., Heidegger, Thomas, Higgs, Andy, Hung, Orlando R., Jagannathan, Narasimhan “Sim”, Jain, Ranu R., Joffe, Aaron M., Joshi, Girish P., Katz, Jeffrey, Keck, Jeffrey P., Jr., Klock, P. Allan, Jr., Krier, Claude, Kristensen, Michael Seltz, Langeron, Olivier, Lee, Sarah A., Levitan, Richard M., Lindsay, Helen A., Mark, Lynette J., Mark, Nathan D., Matioc, Adrian, McIsaac, Joseph H., III, McNarry, Alistair F., Mick, Nathan W., Mirsky, David M., Moise, Ovidiu, Mort, Thomas C., Munnur, Uma, Nagrebetsky, Alexander, Naruse, Robert, Nekhendzy, Vladimir, Nishioka, Hokuto, O'Grady, Kevin F., Ogunnaike, Babatunde, Olivar, Hernando, Osborn, Irene P., Patel, Anil, Patel, Bela, Piacentini, Alberto G.G., Quinlan, Joseph J., Rosenblatt, William H., Roy, Soham, Russo, Sebastian G., Sakles, John C., Sanchez, Antonio, Schiff, Jan-Henrik, Schmitz, Bettina Ulrike, Schwartz, David E., Sharar, Sam R., Sheinbaum, Roy, Sivak, Erica L., Sparrow, Kathryn Anne, Sridhar, Srikanth, Stephens, Christopher, Straker, Tracey, Suresh, Maya S., Teoh, Wendy H., Timmermann, Arnd, Tokarczyk, Arthur J., Urdaneta, Felipe, Urman, R., Vaida, Sonia, Vanga, Naveen, Vender, Jeffery S., Wali, Ashutosh, Walther, Andreas, Warner, Mark T., Wilkinson, David John, Wilson, William C., and Zakowski, Mark

Published
2018
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22. Doyon Utilities Raptor Transmission Line Phase I Archaeological Survey Report, United States Air Force Joint Base Elmendorf-Richardson, Alaska

Author

Blanchard, Morgan R. and Higgs, Andy

Subjects
Final Report, Doyon Utilities Raptor Transmission Line, Ethnohistoric Research, Building 986, Building 700, Building 10909, United States Air Force, Anchorage, AK, Ship Creek, Building 4905, Building 35610, Building 10871, Cook Inlet, ANC-01297, ANC-01171, Historic District, ANC-02910, ANC-01228, Building 953, Building 5887, ANC-00014, Building 4913, Reconnaissance / Survey, Building 35620, Homestead Era, ANC-01063, ANC-01061, ANC-01062, Building 10907, Cultural Resources, Building 724, Building 5893, ANC-01199, ANC-03059, ANC-01276, ANC-03939, Building 35750, ANC-03938, ANC-03937, Building 35752, ANC-03936, Building 12757, ANC-01076, ANC-01274, ANC-03057, ANC-01198, ANC03937, ANC-01270, Building 25620, ANC-01071, ANC-03945, Historic Background Research, Building 736, ANC-03944, ANC-03943, Building 733, Methodology, Theory, or Synthesis, ANC-03942, Phase I Archaeological Survey, ANC-01201, ANC-03941, Building 732, ANC-01202, ANC-03940, Fort Richardson, AK, Building 730, ANC-01200, ANC-01929, Building 36012, Alaska (State / Territory), Research Design / Data Recovery Plan, ANC-03946, Joint Base Elmendorf-Richardson, Building 7, Human Remains, Building 25610, ANC-03063
Abstract

Doyon Utilities, LLC implemented the construction of the Raptor Transmission Line (RTL) located on Joint Base Elmendorf-Richardson (JBER) at the direction of the 673d Civil Engineering Squadron to enhance the electrical distribution system found on the installation. Weston Solutions, Inc. (WS) has been contracted by Doyon Utilities to provide environmental permitting services for the project. WS contracted with Northern Land Use Research (NLUR) to conduct a Level I "reconnaissance" archaeological survey, as defined by the Alaska Office of History and Archaeology (OHA) (Historic Preservation Series No. 11, revised 2003), of the RTL right-of-way (ROW), primarily focused on sections of the proposed route found on the former Elmendorf Air Force Base located south of Grady Road. The findings within this report are not focused on the previously completed archeological surveys that were executed prior to the 2008 Utilities Privatization of Fort Richardson and ROW conveyances to Doyon Utilities outside of this effort. The findings within those areas are outside the scope of this report.

Published
2012
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23. Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

Author

Mifsud, Borbala, primary, Tavares-Cadete, Filipe, additional, Young, Alice N, additional, Sugar, Robert, additional, Schoenfelder, Stefan, additional, Ferreira, Lauren, additional, Wingett, Steven W, additional, Andrews, Simon, additional, Grey, William, additional, Ewels, Philip A, additional, Herman, Bram, additional, Happe, Scott, additional, Higgs, Andy, additional, LeProust, Emily, additional, Follows, George A, additional, Fraser, Peter, additional, Luscombe, Nicholas M, additional, and Osborne, Cameron S, additional

Published
2015
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24. The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements

Author

Schoenfelder, Stefan, primary, Furlan-Magaril, Mayra, additional, Mifsud, Borbala, additional, Tavares-Cadete, Filipe, additional, Sugar, Robert, additional, Javierre, Biola-Maria, additional, Nagano, Takashi, additional, Katsman, Yulia, additional, Sakthidevi, Moorthy, additional, Wingett, Steven W., additional, Dimitrova, Emilia, additional, Dimond, Andrew, additional, Edelman, Lucas B., additional, Elderkin, Sarah, additional, Tabbada, Kristina, additional, Darbo, Elodie, additional, Andrews, Simon, additional, Herman, Bram, additional, Higgs, Andy, additional, LeProust, Emily, additional, Osborne, Cameron S., additional, Mitchell, Jennifer A., additional, Luscombe, Nicholas M., additional, and Fraser, Peter, additional

Published
2015
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27. Lost in transition: use of SpO2 in the Australian and New Zealand College of Anaesthetists transition tool. Reply to Br J Anaesth 2020; 125: e465-6.

Author

Rehak, Adam, Chrimes, Nicholas, and Higgs, Andy

Subjects
*COLLEGE student adjustment, *AUSTRALIANS
Abstract

Reply to Br J Anaesth 2020; 125: e465-6. Lost in transition: use of SpO2 in the Australian and New Zealand College of Anaesthetists transition tool. Airway management, emergency front-of-neck airway, oxygenation, cannot intubate, cannot oxygenate, cognitive aid, guideline. [Extracted from the article]

Published
2021
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29. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries.

Author

Russotto V, Myatra SN, Laffey JG, Tassistro E, Antolini L, Bauer P, Lascarrou JB, Szuldrzynski K, Camporota L, Pelosi P, Sorbello M, Higgs A, Greif R, Putensen C, Agvald-Öhman C, Chalkias A, Bokums K, Brewster D, Rossi E, Fumagalli R, Pesenti A, Foti G, and Bellani G

Subjects
Aged, Critical Illness mortality, Female, Heart Arrest etiology, Humans, Hypoxia etiology, Intensive Care Units, Intubation, Intratracheal methods, Logistic Models, Male, Medical Errors statistics & numerical data, Middle Aged, Prospective Studies, Respiration, Artificial, Vasoconstrictor Agents therapeutic use, Critical Illness therapy, Hypotension etiology, Intubation, Intratracheal adverse effects, Respiratory Insufficiency therapy
Abstract

Importance: Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events., Objective: To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients., Design, Setting, and Participants: The International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients (INTUBE) study was an international, multicenter, prospective cohort study involving consecutive critically ill patients undergoing tracheal intubation in the intensive care units (ICUs), emergency departments, and wards, from October 1, 2018, to July 31, 2019 (August 28, 2019, was the final follow-up) in a convenience sample of 197 sites from 29 countries across 5 continents., Exposures: Tracheal intubation., Main Outcomes and Measures: The primary outcome was the incidence of major adverse peri-intubation events defined as at least 1 of the following events occurring within 30 minutes from the start of the intubation procedure: cardiovascular instability (either: systolic pressure <65 mm Hg at least once, <90 mm Hg for >30 minutes, new or increase need of vasopressors or fluid bolus >15 mL/kg), severe hypoxemia (peripheral oxygen saturation <80%) or cardiac arrest. The secondary outcomes included intensive care unit mortality., Results: Of 3659 patients screened, 2964 (median age, 63 years; interquartile range [IQR], 49-74 years; 62.6% men) from 197 sites across 5 continents were included. The main reason for intubation was respiratory failure in 52.3% of patients, followed by neurological impairment in 30.5%, and cardiovascular instability in 9.4%. Primary outcome data were available for all patients. Among the study patients, 45.2% experienced at least 1 major adverse peri-intubation event. The predominant event was cardiovascular instability, observed in 42.6% of all patients undergoing emergency intubation, followed by severe hypoxemia (9.3%) and cardiac arrest (3.1%). Overall ICU mortality was 32.8%., Conclusions and Relevance: In this observational study of intubation practices in critically ill patients from a convenience sample of 197 sites across 29 countries, major adverse peri-intubation events-in particular cardiovascular instability-were observed frequently.

Published
2021
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