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BackgroundPrevious work performed by our group demonstrated that intermittent reductions in bispectral index (BIS) values were found during neurofeedback following mindfulness instructions. Hypnosis was induced to enhance reductions in BIS values. ObjectiveThis study aims to assess physiologic relaxation and explore its associations with BIS values using autonomic monitoring. MethodsEach session consisted of reading a 4-minute baseline neutral script and playing an 18-minute hypnosis tape to 3 researchers involved in the BIS neurofeedback study. In addition to BIS monitoring, autonomic monitoring was performed, and this included measures of electromyography (EMG), skin temperature, skin conductance, respiratory rate, expired carbon dioxide, and heart rate variability. The resulting data were analyzed using two-tailed t tests, correlation analyses, and multivariate linear regression analyses. ResultsWe found that hypnosis was associated with reductions in BIS (P

Background: In 2014, this group published an investigation of surgical patients from 2012 who had substantial rates of postoperative hypoxemia (POH) and perioperative pulmonary aspiration (POPA). Therefore, we investigated whether intraoperative reverse Trendelenburg positioning (RTP) decreases POH and POPA rates. Methods: Consecutive ASA I-IV surgical patients who had preoperative pulmonary stability requiring general anesthesia with endotracheal intubation were evaluated. Using pulse oximetry, hypoxemia was documented intraoperatively and during the 48 h following PACU discharge. POPA was the presence of a pulmonary infiltrate with hypoxemia. In early 2015, a multifaceted effort was undertaken to enhance anesthesiologist and operating nurse awareness of RTP to potentially decrease POH and POPA rates. Analyses included (1) combining 2012 and 2015 cohorts to assess risk conditions, (2) comparing post-campaign 2015 (increased RTP) and 2012 cohorts, and (3) comparing 2015 patients with audit-documented RTP during surgery to the other 2015 patients. Results: Combining the 500 patients in 2012 with the 1000 in 2015 showed that POH had increased mortality (2.3%), compared to no POH (0.2%; p = 0.0004). POH had increased postoperative length of stay (LOS) (4.6 days), compared to no POH (2.0 days; p < 0.0001). POPA had increased mortality (7.7%) and LOS (8.8 days), compared to no POPA (0.4%; p = 0.0004; 2.3 days; p < 0.0001). Open aortic, cranial, laparotomy, and neck procedures had greater POH (41.3%) and LOS (4.0 days), compared to other procedures (16.3%; p < 0.0001; 2.2 days; p < 0.0001). Glycopyrrolate on induction had lower POH (17.4%) and LOS (1.9 days), compared to no glycopyrrolate (21.6%; p = 0.0849; 2.7 days; p < 0.0001). POH was lower (18.1%) in 2015, than in 2012 (25.6%; p = 0.0007). POPA was lower with RTP in 2015 (0.6%), than in 2012 (4.8%; p = 0.0088). For the 2015 patients, LOS was lower with audit-documented RTP (2.2 days), compared to other patients (2.7 days; p = 0.0246). Conclusions: These findings are only hypothesis-generating. A randomized clinical trial is needed to confirm whether RTP has an inverse association with POH and POPA, and if RTP and glycopyrrolate are associated with improved outcomes. [ABSTRACT FROM AUTHOR]

Background: In a smaller experience, the authors previously demonstrated that end-tidal carbon dioxide (PetCO2) and cardiac output (CO) had a positive association in emergently intubated trauma patients during Emergency Department resuscitation. The aim of this larger study was to reassess the relationship of PetCO2 with CO and identify patient risk-conditions influencing PetCO2 and CO values. Methods: The investigation consists of acutely injured trauma patients requiring emergency tracheal intubation. The study focuses on the prospective collection of PetCO2 and noninvasive CO monitor (NICOM®) values in the Emergency Department. Results: From the end of March through August 2011, 73 patients had 318 pairs of PetCO2 (mm Hg) and CO (L/min.) values. Mean data included Injury Severity Score (ISS) ≥15 in 65.2%, Glasgow Coma Score of 6.4 ± 4.6, hypotension in 19.0%, and death in 34.3%. With PetCO2 ≤ 25 (15.9 ± 8.0), systolic blood pressure was 77.0 ± 69, CO was 3.2 ± 3.0, cardiac arrest was 60.4%, and mortality was 84.9%. During hypotension, CO was lower with major blood loss (1.9), than without major loss (5.0; P = 0.0008). Low PetCO2 was associated with low CO (P < 0.0001). Low PetCO2 was associated (P ≤ 0.0012) with ISS > 20, hypotension, bradycardia, major blood loss, abnormal pupils, cardiac arrest, and death. Low CO was associated (P ≤ 0.0059) with ISS > 20, hypotension, bradycardia, major blood loss, abnormal pupils, cardiac arrest, and death. Conclusions: During emergency department resuscitation, a decline in PetCO2 correlates with decreases in noninvasive CO in emergently intubated trauma patients. Decreasing PetCO2 and declining NICOM CO are associated with hemodynamic instability, hemorrhage, abnormal pupils, and death. The study indicates that NICOM CO values are clinically discriminate and have physiologic validity. [ABSTRACT FROM AUTHOR]

Objectives Because the Injury Severity Score (ISS) has not been fully endorsed for determining trauma undertriage, we investigated its precision. This study aimed to 1) compute undertriage proportions using the Peng and Cribari methods; 2) compare risk conditions and outcomes for patients with ISS ≥16 who were classified according to an activation or consultation status; 3) calculate proportions of patients with ISS ≥16, without and with qualifications (death or increased length of stay), as potential categories for assessing undertriage in trauma consultation patients; and 4) compute the undertriage proportion among trauma consultation patients by using an intracranial hemorrhage (ICH)-Glasgow Coma Scale score (GCS)-ISS categorization method and employing targeted electronic medical record audits (EMRA). Methodology Age, ISS, GCS, activation status (full, partial, or consultation), injury mechanism, death, intensive care stay, and hospital stay were obtained from the trauma registry. An adverse outcome (AO) was death, intensive care stay ≥two days, or hospital stay >five days. ICH status, clinical details, and comorbidity were obtained from EMRA. Each consultation patient was assigned to an ICH-GCS-ISS category with targeted EMRA. Results Of 2,076 consecutive trauma center admissions, 405 had full activation, 640 had partial activation, and 1,031 had consultation. Using Peng and Cribari methods, undertriage proportions were 64.2% and 21.7%, respectively. Compared with consultation patients with ISS ≥16, full or partial activation patients with ISS ≥16 had much higher proportions (p<0.0001) of non-fall mechanisms, age <70 years, GCS <15, ISS ≥25, mortality, intensive care admission, and hospital stay >five days. The proportions of consultation nonqualified ISS ≥16 undertriage and ISS ≥16-AO undertriage were 21.1% (218 ISS ≥16÷1,031) and 9.8% (101 ISS ≥16-AO÷1,031), respectively. Of the 101 ISS ≥16-AO patients, 79.2% were aged ≥70 years or had comorbidity. The consultation ISS ≥16-death undertriage proportion was 1.5% (15 ISS ≥16-deaths÷1,031). The ICH-GCS-ISS consultation categorization undertriage proportion was 11.0% (113÷1,031). ICH-GCS-ISS undertriage proportions were as follows: ICH with GCS <15, 77/77; no ICH with ISS ≥16 (EMRA for major injury), 14/60; scene ICH & GCS 15 & ISS ≥16, 0/43; transfer ICH & GCS 15 & ISS ≥16 (EMRA for intracranial mass effect), 22/69; no ICH with ISS <16, 0/629; and ICH & GCS 15 & ISS <16, 0/153. Conclusions Because ISS ≥16 consultation and activation patient risk conditions and outcomes are dissimilar, commingling these cohorts for undertriage assessment is dubious. Death and increased length of stay-qualified ISS ≥16 with EMRA can be useful to assess undertriage in trauma consultation patients. Because most ISS ≥16-AO consultations were elderly or had comorbidity, the benefit of trauma activation is uncertain. Consultation ICH-GCS-ISS categorization with EMRA was needed in only 12%, indicating a relatively facile undertriage method., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Bon Secours Mercy Health Institutional Review Board issued approval 2024-Trauma-Dunham. The current retrospective study was reviewed by the local institutional review board and determined to be qualified for exemption according to Exempt Category 4. (Bon Secours Mercy Health, IRB number: 2024-Trauma-Dunham). The need for informed consent was waived. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Dunham et al.)

Background To the best of our knowledge, we have found no trauma consultation study investigating Injury Severity Score (ISS) ≥16, Glasgow Coma Scale score (GCS), intracranial hemorrhage (ICH), age, preexisting medical conditions (PEMC), and smoking as risk conditions for mortality. Objective We aimed to assess ISS ≥16 and other postinjury and preinjury conditions for associations with death and adverse outcomes (AO). Methodology Consecutive consultations of patients admitted to a trauma center over 18 months were investigated. Data were obtained from the trauma registry and the electronic medical record. AO were death, intensive care unit stay of two days or more, or hospital stay exceeding five days. Results Among 1,031 trauma consultations, 28 patients (2.7%) died and 258 (25.0%) had AO. The proportion of ISS ≥16 was greater with death (53.6% (15/28)) than with survival (20.2% (203/1,003); p<0.0001). Of 218 patients with ISS ≥16, 93.1% (n = 203) survived, whereas 46.4% (13/28) died with an ISS <16. The area under the receiver operating characteristic curve for ISS ≥16 and the death relationship was 0.7 (p<0.001). The proportion of GCS <15 was greater with death (42.9% (12/28)) than with survival (13.1% (131/1,003); p<0.0001). The incidence of ICH was greater with death (57.1% (16/28)) than with survival (32.5% (326/1,003); p=0.0063). The incidence of age ≥70 was greater with death (89.3% (25/28)) than with survival (48.2% (483/1,003); p<0.0001). The proportion of PEMC was greater with death (85.7% (24/28)) than with survival (50.8% (509/1,003); p=0.0002). The proportion of smoking history was similar with death (50.0% (14/28)) and survival (52.5% (527/1,003); p=0.7905). Death had independent associations with age (p=0.0019), GCS (p<0.0001), ISS ≥16 (p=0.0074), and PEMC (p=0.0137). AO had univariate associations with ISS ≥16 (p<0.0001), GCS <15 (p<0.0001), ICH (p=0.0004), and PEMC (p=0.0002). Area under the receiver operating characteristic curve for ISS ≥16 and the AO relationship was 0.6 (p<0.001). AO had independent associations with GCS (p<0.0001), ISS ≥16 (p<0.0001), and PEMC (p=0.0005). Conclusions ISS ≥16 alone is marginally accurate for classifying trauma consultation patients who died or had AO. Other postinjury and preinjury conditions, such as GCS, ICH, age, and PEMC, should also be considered when assessing one's risk of death and AO., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Bon Secours Mercy Health issued approval 2024-Trauma-Dunham. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Dunham et al.)

Introduction The relationship between cigarette smoking and arterial carboxyhemoglobin (CoHb) in trauma activation patients has not been investigated. The aim was to determine if cigarette smoking is associated with drug abuse history and arterial CoHb levels. Methodology This is a retrospective review of level I trauma center activations aged 18-60 during 2018-2020. A medical record audit was performed to assess each patient's cigarette smoking and drug abuse history and admission arterial CoHb level. The CoHb levels and smoking history for each patient were used to construct a receiver operating characteristic curve. Results Of the 742 trauma activations aged 18-60, 737 (99.3%) had a documented cigarette smoking history. Smoking history was positive in 49.7% (366) and negative in 50.3% (371). The positive smoking proportion was greater in patients with a drug abuse history (63.9% (234/366)) than those with a negative history (31.0% (115/371); p<0.0001; odds ratio=4.0). In 717 patients with a CoHb value, the CoHb was higher in smokers (3.9±2.2%) than in non-smokers (0.5±0.4%; p<0.0001; Cohen d=2.2). A CoHb >1.5% was higher in smokers (93.3% (333/357)) than non-smokers (1.7% (6/360); p<0.0001; odds ratio=818.6). The receiver operating characteristic curve for the relationship between CoHb and cigarette smoking history showed an area under the curve of 0.980 (p<0.0001). Using an arterial CoHb level >1.5% to predict a positive smoking history and a CoHb level ≤1.5% to predict a non-smoking history, sensitivity was 93.3% (333/357), specificity was 98.3% (354/360), and accuracy was 95.8% (687/717). Conclusion Cigarette smoking in trauma activations aged 18-60 is associated with drug abuse history and increased arterial CoHb levels on trauma center arrival., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Dunham et al.)

Because few studies have assessed blood alcohol concentration (BAC)-positive risk conditions in trauma activation patients, this retrospective investigation pursued such an analysis. The parent database included consecutive trauma center admissions from January 21 to July 21 for 2018-2020. The supplementary electronic medical record audit of trauma activation patients aged 18-60 years (TA18-60) assessed alcohol misuse, smoking history, and serum bicarbonate levels. An alcohol misuse risk score was created by assigning a value of 0 (no) or 1 (yes) for each risk condition: 1) smoking history, 2) BAC-positive status, 3) BAC ≥ 100 mg/dL with Glasgow Coma Scale score (GCS) ≥ 13, 4) age ≥ 40 years, and 5) bicarbonate level ≥ 20 mmol/L in BAC-positive patients and summing the total score (range, 0-5). Of 2,076 patients, BAC testing occurred in 60.9% (n = 1,265). BAC positivity was greater in TA18-60 (36.9%) than in other patients (20.8%; P < 0.0001; odds ratio [OR] = 2.2). In the TA18-60 audit (n = 742), categorizations were available for BAC status, 98.5%; smoking history, 99.3%; alcohol misuse history, 99.5%; and bicarbonate level, 99.5%. BAC positivity was greater in smokers (41.3%) than in non-smokers (31.5%; P = 0.0061; OR = 1.5). BAC positivity was greater with alcohol misuse (87.0%) than without (17.7%; P < 0.0001; OR = 31.2). BAC-positive was associated with a greater proportion of bicarbonate levels < 20 mmol/L (52.0%) than BAC-negative (31.8%; P < 0.0001; OR = 2.3). The alcohol misuse proportion was greater with an alcohol misuse risk score of 3-5 (74.4% [142/191]) than with a risk score of 0-2 (10.4% [57/546]; P < 0.0001; OR = 24.9; area under the receiver operating characteristic curve = 0.89). This retrospective study demonstrates that BAC positivity is associated with TA18-60, smoking and alcohol misuse histories, and metabolic acidosis. An alcohol misuse history is associated with multiple risk conditions. Trauma center leadership should provide procedures to identify patients who are BAC-positive or have a positive smoking or alcohol misuse history. Then, such patients should be referred to care providers who can offer assistance and guidance for enhancing overall patient wellbeing., Competing Interests: None., (IJBT Copyright © 2022.)

Trauma nurses commonly encounter stress and burnout and have increased negative affect states and decreased positive affect traits. This study investigated whether trauma center nurses would have improvements in wellbeing scores after reading and contemplating Spiritual Flow: Pathways to Proficient Patient Care and Nurse & Physician Wellbeing ( Spiritual Flow ). Trauma center surgical intensive care unit nurses completed a baseline and follow-up survey before and after reading and contemplating Spiritual Flow , which provides insights into spirituality and mindfulness. The survey contained four positive affect (PA) items, each rated 1-very little to 5-extremely, that were summed to create a PA score (PAS). The seven negative affect (NA) survey items were similarly rated and reverse coded, 1-extremely to 5-very little, to create a nonstress score (NSS). The PAS (4-20) and NSS (7-35) were summed to create a wellbeing score (WS). Nurses rated the degree to which they felt more peaceful or inspired after contemplating the book. Thirty-seven of 39 (95%) routine nursing staff members completed both surveys. Follow-up values increased for WS (P = 0.0001) and NSS (P = 0.0001) after reading and contemplating Spiritual Flow compared to baseline values. No changes occurred for PAS (P = 0.1606). Because 16% of nurses had a high PAS on the baseline survey, further analyses were performed on the other 84%. Significantly increased values were noted on follow-up for PAS (P = 0.0171), NSS (P = 0.0015), and WS (P = 0.0003) compared to baseline scores. Of 37 nurses, 24 (64.9%) rated feeling more peaceful and/or inspired as moderately or quite a bit. This pilot study suggests that contemplating Spiritual Flow was associated with improvements in surgical intensive care trauma center nurse wellbeing. These preliminary findings need to be confirmed in an investigation that includes a control group and randomization., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Although the first author is a co-author of the work Spiritual Flow, the first author receives no royalties from the published book., (IJBT Copyright © 2021.)

Introduction: There is controversy regarding obesity or body mass index (BMI) effects on postinjury mortality and mechanical ventilation. The aim was to assess outcome associations with BMI and postinjury blood glucose and cholesterol., Method: Adult blunt traumatic brain injury patients admitted to a level I trauma center and requiring ≥ 3 days of intensive care were investigated. Admission blood glucose and day-4 total cholesterol were captured from the medical records. Cholesterol ratio was calculated by dividing day-4 values by published national normative levels according to sex, age, and injury date., Results: The parent cohort included 588 patients. The ventilator days ≥ 10 or died group, when compared to the ventilator days < 10 and lived group, had higher Injury Severity Score (ISS) (29.2±9.9 versus [vs.] 23.7±9.7, P < 0.0001), BMI (27.9±6.8 vs. 26.0±5.5, P = 0.0002), and admission glucose (182.6±79 vs. 155.4±59 mg/dl, P < 0.0001, n = 476) and lower emergency department Glasgow Coma Scale score (ED GCS) (6.9±4.7 vs. 10.3±5.0, P < 0.0001) and cholesterol ratio (0.64±0.2 vs. 0.70±0.2, P = 0.0018, n = 364). The ventilator days ≥ 10 or died group had independent associations with increased ISS (P = 0.0709), decreased ED GCS (P = 0.0078), and increased BMI÷cholesterol ratio (P = 0.0003). The ventilator days ≥ 10 or died group had independent associations with increased ISS (P = 0.0013), decreased ED GCS (P < 0.0001), and increased BMI × glucose (P < 0.0001). Ventilator days were increased with higher ISS (P < 0.0001), BMI (P = 0.0014) and glucose (P = 0.0031) and with lower ED GCS (P < 0.0001) and cholesterol ratio (P = 0.0004). Ventilator days had independent associations with increased ISS (P < 0.0001), decreased ED GCS (P = 0.0041), and increased BMI÷cholesterol ratio (P = 0.0010). Ventilator days had independent associations with increased ISS (P < 0.0001), decreased ED GCS (P < 0.0001), and increased BMI × glucose (P = 0.0041)., Conclusion: For TBI patients, valid risk assessment measurements include ISS (anatomic injury burden), ED GCS (brain function), BMI (preinjury weight status), admission glucose (postinjury metabolism), and day-4 cholesterol ratio (postinjury inflammation)., Competing Interests: None., (IJBT Copyright © 2020.)

Fifty-seven level I trauma center nurses/physicians participated in a 4-day intervention to learn relaxed alertness using mindfulness-based instructions and EEG neurofeedback. Neurofeedback was provided by a Bispectral Index TM (BIS) system that continuously displays a BIS value (0-100) on the monitor screen. Reductions in the BIS value indicate that power in a high-frequency band (30-47 Hz) is decreased and power in an intermediate band (11-20 Hz) is increased. A wellbeing tool with four positive affect and seven negative affect items based on a 5-category Likert scale was used. The wellbeing score is the sum of the positive affect items (positive affect score) and the reverse-scored negative affect items (non-stress score). Of functional concern were four negative affect items rated as moderately, quite a bit, or extremely in a large percent. Of greater concern were all four positive affect items rated as very slightly or none at all, a little, or moderately in over half of the participants. Mean and nadir BIS values were markedly decreased during neurofeedback when compared to baseline values. Post-session relaxation scores were higher than pre-session relaxation scores. Post-session relaxation scores had an inverse relationship with mean and nadir BIS values. Mean and nadir BIS values were inversely associated with NFB cognitive states (i.e., widening the visual field, decreasing effort, attention to space, and relaxed alertness). For all participants, the wellbeing score was higher on day 4 than on day 1. Participants had a higher wellbeing score on day 4 than a larger group of nurses/physicians who did not participate in the BIS neurofeedback trial. Eighty percent of participants demonstrated an improvement in the positive affect or non-stress score on day 4, when compared to day 1; the wellbeing, non-stress, and positive affect scores were substantially higher on day 4 than on day 1. Additionally, for that 80% of participants, the improvements in wellbeing and non-stress were associated with reductions in day 3 BIS values. These findings indicate that trauma center nurses/physicians participating in an EEG neurofeedback trial with mindfulness instructions had improvements in wellbeing. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03152331. Registered May 15, 2017., (Copyright © 2019 Dunham, Burger, Hileman, Chance, Hutchinson, Kohli, DeNiro, Tall and Lisko.)

Objective: We hypothesized that lung injury and rib cage fracture quantification would be associated with adverse outcomes., Subjects and Methods: Consecutive admissions to a trauma center with Injury Severity Score ≥ 9, age 18-75, and blunt trauma. CT scans were reviewed to score rib and sternal fractures and lung infiltrates. Sternum and each anterior, lateral, and posterior rib fracture was scored 1 = non-displaced and 2 = displaced. Rib cage fracture score (RCFS) = total rib fracture score + sternal fracture score + thoracic spine Abbreviated Injury Score (AIS). Four lung regions (right upper/middle, right lower, left upper, and left lower lobes) were each scored for % of infiltrate: 0% = 0; ≤ 20% = 1, ≤ 50% = 2, > 50% = 3; total of 4 scores = lung infiltrate score (LIS)., Results: Of 599 patients, 193 (32%) had 854 rib fractures. Rib fracture patients had more abdominal injuries (p < 0.001), hemo/pneumothorax (p < 0.001), lung infiltrates (p < 0.001), thoracic spine injuries (p = 0.001), sternal fractures (p = 0.0028) and death or need for mechanical ventilation ≥ 3 days (Death/Vdays ≥ 3) (p < 0.001). Death/Vdays ≥ 3 was independently associated with RCFS (p < 0.001), LIS (p < 0.001), head AIS (p < 0.001) and abdominal AIS (p < 0.001). Of the 193 rib fracture patients, Glasgow Coma Score 3-12 or head AIS ≥ 2 occurred in 43%. A lung infiltrate or hemo/pneumothorax occurred in 55%. Thoracic spine injury occurred in 23%. RCFS was 6.3 ± 4.4 and Death/Vdays ≥ 3 occurred in 31%. Death/Vdays ≥ 3 rates correlated with RCFS values: 19% for 1-3; 24% for 4-6; 42% for 7-12 and 65% for ≥ 13 (p < 0.001). Death/Vdays ≥ 3 was independently associated with RCFS (p = 0.02), LIS (p = 0.001), head AIS (p < 0.001) and abdominal AIS (p < 0.001). Death/Vdays ≥ 3 association was better for RCFS (p = 0.005) than rib fracture score (p = 0.08) or number of fractured ribs (p = 0.80)., Conclusion: Rib fracture patients have increased risk for truncal injuries and adverse outcomes. Adverse outcomes are independently associated with rib cage fracture burden. Severity of head, abdominal, and lung injuries also influence rib fracture outcomes.