Search

Your search keyword '"Hilten, J. A. van"' showing total 14 results
Start Over Author "Hilten, J. A. van"
14 results on '"Hilten, J. A. van"'

3. Cognitive impairment in Parkinson's disease.

Author

Verbaan, D., Marinus, J., Visser, M., Rooden, S. M. Van, Stiggelbout, A. M., Middelkoop, H. A. M., and Hilten, J. J. Van

Subjects
PARKINSON'S disease, COGNITION disorders, NEUROLOGIC manifestations of general diseases, NEUROLOGY, MEDICAL care
Abstract

Background: Cognitive impairment plays a role in Parkinson's disease (PD) and has important consequences for patient management. However, many aspects of cognitive impairment in PD remain unclear because of the use of different and often invalid measurement instruments. In this study, a reliable and valid instrument, the SCales for Outcomes in PArkinson's disease-COGnition (SCOPA-COG), was used. Aim: To evaluate cognitive functioning in a large cohort of patients with Parkinson's disease and to assess the relations with demographic, disease related and clinical variables. Methods: A cohort of 400 patients with PD was evaluated for cognition, motor and non-motor domains, as well as for demographic and disease related characteristics. Results were compared with 150 controls matched for overall age, sex and education distribution. Results: Patients with PD scored significantly lower on all cognitive subdomains compared with controls, with the largest differences for executive functioning and memory. After correction for age and years of education, 22% of patients had impaired cognition, as measured by the total SCOPA-COG score, compared with controls. Across all patients, more severe cognitive impairment was associated with significantly more impairment in motor, autonomic, depressive and psychotic domains. Patients with the postural instability gait difficulty (PIGD) dominant phenotype showed more cognitive impairment compared with patients with the tremor dominant phenotype. Contrary to tremor scores, PIGD scores significantly worsened with increasing disease severity. Conclusions: Cognition is an important domain of the clinical spectrum of PD and poorer cognitive performance is associated with greater impairment in motor and non-motor domains in PD. The difference in cognitive scores between PIGD dominant patients and tremor dominant patients likely reflects more advanced disease. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

4. International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson diseaseSYMBOL

Author

Martinez-Martin, P, Rodriguez-Blazquez, C, Abe, K, Bhattacharyya, K B., Bloem, B R., Carod-Artal, F J., Prakash, R, Esselink, R A.J., Falup-Pecurariu, C, Gallardo, M, Mir, P, Naidu, Y, Nicoletti, A, Sethi, K, Tsuboi, Y, Hilten, J J. van, Visser, M, Zappia, M, and Chaudhuri, K R.

Abstract

Nonmotor symptoms (NMS) have a great impact on patients with Parkinson disease (PD). The Non-Motor Symptoms Scale (NMSS) is an instrument specifically designed for the comprehensive assessment of NMS in patients with PD. NMSS psychometric properties have been tested in this study.

Published
2009
Full Text
View/download PDF

6. Patient-reported autonomic symptoms in Parkinson disease

Author

Verbaan, D, Marinus, J, Visser, M, Rooden, S M. van, Stiggelbout, A M., and Hilten, J J. van

Abstract

There is a wide range of autonomic symptoms (AS) in Parkinson disease (PD), but the full spectrum has never been evaluated with a validated instrument and in comparison with control subjects. In this study a reliable and valid instrument, the SCOPA–AUT, was used to evaluate the occurrence of AS in a large cohort of patients with PD and control subjects and to assess the relations with demographic, disease-related, and clinical variables.

Published
2007
Full Text
View/download PDF

7. Assessment of cognition in Parkinson’s disease

Author

Marinus, J., Visser, M., Verwey, N. A., Verhey, F. R.J., Middelkoop, H. A.M., Stiggelbout, A. M., and Hilten, J. J. van

Abstract

To develop a short, practical instrument that is sensitive to the specific cognitive deficits in Parkinson’s disease (PD) for comparing groups in research situations and for assessing change in cognitive functioning over time.

Published
2003
Full Text
View/download PDF

8. Diagnostic criteria used in studies of reflex sympathetic dystrophy

Author

Beek, W.-J. T. van de, Schwartzman, R. J., Nes, S. I. van, Delhaas, E. M., and Hilten, J. J. van

Abstract

Assessment of the diagnostic criteria of reflex sympathetic dystrophy (RSD) and evaluation of the impact of the introduction of the diagnostic criteria of complex regional pain syndrome (CRPS) on the international application of diagnostic criteria of RSD.

Published
2002

9. Multifocal or generalized tonic dystonia of complex regional pain syndrome: A distinct clinical entity associated with HLA-DR13

Author

Hilten, J. J. Van, Beek, W. J. T. Van De, and Roep, B. O.

Abstract

We report on 26 patients with a distinct phenotype of complex regional pain syndrome that progressed toward a multifocal or generalized tonic dystonia. The dystonia initiated distally, involved mainly flexor muscles, and was associated with sensory and autonomic symptoms. Dryness of the eyes or mouth and bladder and bowel disturbances were frequently reported. There was no increase in the familial prevalence of autoimmune-mediated diseases. Compared with controls, a significant elevation of HLA-DR13 was found in the patients. Thus, HLA-DR13 may be a factor indicating susceptibility to this distinct phenotype of complex regional pain syndrome. Ann Neurol 2000;48:113–116

Published
2000
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results