Search

Your search keyword '"Hilton, Matthew"' showing total 792 results
Start Over Author "Hilton, Matthew"
792 results on '"Hilton, Matthew"'

2. Index

Author

Hilton, Matthew

Published
2009

7. Conclusion

Author

Hilton, Matthew

Published
2009

8. Notes

Author

Hilton, Matthew

Published
2009

12. 6 Backlash

Author

Hilton, Matthew

Published
2009

19. Searching for high-z radio galaxies with the MGCLS

Author

Knowles, Kenda, Manaka, Sinah M., Bietenholz, Michael F., Cotton, William D., Hilton, Matthew, Kolokythas, Konstantinos, Loubser, S. Ilani, and Oozeer, Nadeem

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present results from a search for high-redshift radio galaxy (H$z$RG) candidates using 1.28 GHz data in the Abell 2751 field drawn from the MeerKAT Galaxy Cluster Legacy Survey (MGCLS). We use the H$z$RG criteria that a radio source is undetected in all-sky optical and infrared catalogues, and has a very steep radio spectrum. We cross-match the radio catalogue against multi-wavelength galaxy catalogues from DECaLS and AllWISE. For those radio sources with no multi-wavelength counterpart, we further implement a radio spectral index criterium of $\alpha < -1$, using in-band spectral index measurements from the wide-band MeerKAT data. Using a 5$\sigma$ signal-to-noise cut on the radio flux densities, we find a total of 274 HzRG candidates: 179 ultra-steep spectrum sources, and 95 potential candidates which cannot be ruled out as they have no spectral information available. The spectral index assignments in this work are complete above a flux density of 0.3 mJy, at least an order of magnitude lower than existing studies in this frequency range or when extrapolating from lower frequency limits. Our faintest HzRG candidates with and without an in-band spectral index measurement have a 1.28\,GHz flux density of 57 $\pm$ 8 $\mu$Jy and 68 $\pm$ 13 $\mu$Jy, respectively. Although our study is not complete down to these flux densities, our results indicate that the sensitivity and bandwidth of the MGCLS data makes them a powerful radio resource to search for H$z$RG candidates in the Southern sky, with 20 of the MGCLS pointings having similar image quality as the Abell~2751 field and full coverage in both DECaLS and AllWISE. Data at additional radio frequencies will be needed for the faintest source populations, which could be provided in the near future by the MeerKAT UHF band (580 -- 1015 MHz) at a similar resolution ($\sim$ 8-10 arcsec)., Comment: 12 pages, 2 figures. To be published in Galaxies, from the conference "A New Window on the Radio Emission from Galaxies, Galaxy Clusters and Cosmic Web: Current Status and Perspectives"

Published
2021

21. The Growth of Intracluster Light in XCS-HSC Galaxy Clusters from $0.1 < z < 0.5$

Author

Furnell, Kate E., Collins, Chris A., Kelvin, Lee S., Baldry, Ivan K., James, Phil A., Manolopoulou, Maria, Mann, Robert G., Giles, Paul A., Bermeo, Alberto, Hilton, Matthew, Wilkinson, Reese, Romer, A. Kathy, Vergara, Carlos, Bhargava, Sunayana, Stott, John P., Mayers, Julian, and Viana, Pedro

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We estimate the Intracluster Light (ICL) component within a sample of 18 clusters detected in XMM Cluster Survey (XCS) data using deep ($\sim$ 26.8 mag) Hyper Suprime Cam Subaru Strategic Program DR1 (HSC-SSP DR1) $i$-band data. We apply a rest-frame ${\mu}_{B} = 25 \ \mathrm{mag/arcsec^{2}}$ isophotal threshold to our clusters, below which we define light as the ICL within an aperture of $R_{X,500}$ (X-ray estimate of $R_{500}$) centered on the Brightest Cluster Galaxy (BCG). After applying careful masking and corrections for flux losses from background subtraction, we recover $\sim$20% of the ICL flux, approximately four times our estimate of the typical background at the same isophotal level ($\sim$ 5%). We find that the ICL makes up about $\sim$ 24% of the total cluster stellar mass on average ($\sim$ 41% including the flux contained in the BCG within 50 kpc); this value is well-matched with other observational studies and semi-analytic/numerical simulations, but is significantly smaller than results from recent hydrodynamical simulations (even when measured in an observationally consistent way). We find no evidence for any links between the amount of ICL flux with cluster mass, but find a growth rate of $2-4$ for the ICL between $0.1 < z < 0.5$. We conclude that the ICL is the dominant evolutionary component of stellar mass in clusters from $z \sim 1$. Our work highlights the need for a consistent approach when measuring ICL alongside the need for deeper imaging, in order to unambiguously measure the ICL across as broad a redshift range as possible (e.g. 10-year stacked imaging from the Vera C. Rubin Observatory)., Comment: Accepted by MNRAS (05/01/2021), 20 pages, 17 figures

Published
2021
Full Text
View/download PDF

22. Pressure profiles and mass estimates using high-resolution Sunyaev-Zel'dovich effect observations of Zwicky 3146 with MUSTANG-2

Author

Romero, Charles E., Sievers, Jonathan, Ghirardini, Vittorio, Dicker, Simon, Giacintucci, Simona, Mroczkowski, Tony, Mason, Brian S., Sarazin, Craig, Devlin, Mark, Gaspari, Massimo, Battaglia, Nicholas, Hilton, Matthew, Bulbul, Esra, Lowe, Ian, and Stanchfield, Sara

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The galaxy cluster Zwicky 3146 is a sloshing cool core cluster at $z=0.291$ that in X-ray imaging does not appear to exhibit significant pressure substructure in the intracluster medium (ICM). The published $M_{500}$ values range between $3.88^{+0.62}_{-0.58}$ to $22.50 \pm 7.58 \times 10^{14}$ M$_{\odot}$, where ICM-based estimates with reported errors $<20$\% suggest that we should expect to find a mass between $6.53^{+0.44}_{-0.44} \times 10^{14}$ M$_{\odot}$ (from Planck, with an $8.4\sigma$ detection) and $8.52^{+1.77}_{-1.47} \times 10^{14}$ M$_{\odot}$ (from ACT, with a $14\sigma$ detection). This broad range of masses is suggestive that there is ample room for improvement for all methods. Here, we investigate the ability to estimate the mass of Zwicky 3146 via the Sunyaev-Zel'dovich (SZ) effect with data taken at 90 GHz by MUSTANG-2 to a noise level better than $15\ \mu$K at the center, and a cluster detection of $104\sigma$. We derive a pressure profile from our SZ data which is in excellent agreement with that derived from X-ray data. From our SZ-derived pressure profiles, we infer $M_{500}$ and $M_{2500}$ via three methods -- $Y$-$M$ scaling relations, the virial theorem, and hydrostatic equilibrium -- where we employ X-ray constraints from \emph{XMM-Newton} on the electron density profile when assuming hydrostatic equilibrium. Depending on the model and estimation method, our $M_{500}$ estimates range from $6.23 \pm 0.59$ to $10.6 \pm 0.95 \times 10^{14}$ M$_{\odot}$, where our estimate from hydrostatic equilibrium, is $8.29^{+1.93}_{-1.24}$ ($\pm 19.1$\% stat) ${}^{+0.74}_{-0.68}$ ($\pm 8.6$\% sys, calibration) $\times 10^{14}$ M$_{\odot}$. Our fiducial mass, derived from a $Y$-$M$ relation is $8.16^{+0.44}_{-0.54}$ ($\pm 5.5$\% stat) ${}^{+0.46}_{-0.43}$ ($\pm 5.5$\% sys, $Y$-$M$) ${}^{+0.59}_{-0.55}$ ($\pm 7.0$\% sys, cal.) $\times 10^{14}$ M$_{\odot}$., Comment: 24 pages, 16 figures; submitted to ApJ

Published
2019
Full Text
View/download PDF

23. Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.

Author

Liu, Zhaoyang, Easson, Garrett WD, Zhao, Jingjing, Makki, Nadja, Ahituv, Nadav, Hilton, Matthew J, Tang, Simon Y, and Gray, Ryan S

Subjects
Growth Plate, Animals, Humans, Mice, Disease Models, Animal, Disease Progression, Receptors, G-Protein-Coupled, Signal Transduction, Mutation, STAT3 Transcription Factor, Intervertebral Disc Displacement, Intervertebral Disc, Intervertebral Disc Degeneration, Disease Models, Animal, Receptors, G-Protein-Coupled, Genetics, Developmental Biology
Abstract

Degenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide and has been attributed primarily to trauma and the accumulation of pathology during aging. While genetic defects have also been associated with disc degeneration, the precise mechanisms driving the initiation and progression of disease have remained elusive due to a paucity of genetic animal models. Here, we discuss a novel conditional mouse genetic model of endplate-oriented disc herniations in adult mice. Using conditional mouse genetics, we show increased mechanical stiffness and reveal dysregulation of typical gene expression profiles of the IVD in adhesion G-protein coupled receptor G6 (Adgrg6) mutant mice prior to the onset of endplate-oriented disc herniations in adult mice. We observed increased STAT3 activation prior to IVD defects and go on to demonstrate that treatment of Adgrg6 conditional mutant mice with a small molecule inhibitor of STAT3 activation ameliorates endplate-oriented herniations. These findings establish ADGRG6 and STAT3 as novel regulators of IVD endplate and growth plate integrity in the mouse, and implicate ADGRG6/STAT3 signaling as promising therapeutic targets for endplate-oriented disc degeneration.

Published
2019

25. G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation

Author

Brozowski, Jaime M., Timoshchenko, Roman G., Serafin, D. Stephen, Allyn, Brittney, Koontz, Jessica, Rabjohns, Emily M., Rampersad, Rishi R., Ren, Yinshi, Eudy, Amanda M., Harris, Taylor F., Abraham, David, Mattox, Daniel, Rubin, Clinton T., Hilton, Matthew J., Rubin, Janet, Allbritton, Nancy L., Billard, Matthew J., and Tarrant, Teresa K.

Published
2022
Full Text
View/download PDF

26. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain

Author

Wang, Kaiyuan, Gu, Yun, Liao, Yihan, Bang, Sangsu, Donnelly, Christopher R., Chen, Ouyang, Tao, Xueshu, Mirando, Anthony J., Hilton, Matthew J., and Ji, Ru-Rong

Subjects
Lung cancer -- Development and progression, Apoptosis -- Comparative analysis, Bone cancer -- Development and progression, Monoclonal antibodies -- Comparative analysis, Cancer prevention -- Comparative analysis, Nivolumab -- Comparative analysis, Cancer pain -- Development and progression, Immunotherapy -- Comparative analysis, Pain management -- Comparative analysis, Cancer metastasis -- Development and progression, Health care industry, Duke University. Hospital -- Evaluation
Abstract

Emerging immune therapy, such as with the anti-programmed cell death-1 (anti-PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with terminal cancer suffer from cancer pain as a result of bone metastasis and bone destruction, but how PD-1 blockade affects bone cancer pain remains unknown. Here, we report that mice lacking Pdcd1 ([Pd1.sup.-/-]) demonstrated remarkable protection against bone destruction induced by femoral inoculation of Lewis lung cancer cells. Compared with WT mice, [Pd1.sup.-/-] mice exhibited increased baseline pain sensitivity, but the development of bone cancer pain was compromised in [Pd1.sup.-/-] mice. Consistently, these beneficial effects in [Pd1.sup.-/-] mice were recapitulated by repeated i.v. applications of nivolumab in WT mice, even though nivolumab initially increased mechanical and thermal pain. Notably, PD-1 deficiency or nivolumab treatment inhibited osteoclastogenesis without altering tumor burden. PD-L1 and CCL2 are upregulated within the local tumor microenvironment, and PD-L1 promoted RANKL-induced osteoclastogenesis through JNK activation and CCL2 secretion. Bone cancer upregulated CCR2 in primary sensory neurons, and CCR2 antagonism effectively reduced bone cancer pain. Our findings suggest that, despite a transient increase in pain sensitivity following each treatment, anti-PD-1 immunotherapy could produce long-term benefits in preventing bone destruction and alleviating bone cancer pain by suppressing osteoclastogenesis., Introduction Cancer pain is experienced by 70% of patients with advanced stage cancer; more than 80% of this pain is attributed to metastatic cancer-induced bone pain (1-3). Generally, bone metastasis [...]

Published
2020
Full Text
View/download PDF

30. Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells

Author

Guo, Wendi, primary, Hoque, Jiaul, additional, Garcia Garcia, Carolina J., additional, Spiller, Kassandra V., additional, Leinroth, Abigail P., additional, Puviindran, Vijitha, additional, Potnis, Cahil K., additional, Gunn, Kiana A., additional, Newman, Hunter, additional, Ishikawa, Koji, additional, Fujimoto, Tara N., additional, Neill, Denae W., additional, Delahoussaye, Abagail M., additional, Williams, Nerissa T., additional, Kirsch, David G., additional, Hilton, Matthew J., additional, Varghese, Shyni, additional, Taniguchi, Cullen M., additional, and Wu, Colleen, additional

Published
2023
Full Text
View/download PDF

35. List of Contributors

Author

Abraham, David, primary, Almeida, Maria, additional, Ambrogini, Elena, additional, Arnold, Andrew, additional, Bakos, Bence, additional, Bergwitz, Clemens, additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binkley, Neil, additional, Bisello, Alessandro, additional, Bonewald, L.F., additional, Bou-Gharios, George, additional, Bouillon, Roger, additional, Bouxsein, Mary L., additional, Boyce, Brendan F., additional, Boyd, Steven, additional, Brandi, Maria Luisa, additional, Burr, David B., additional, Calvi, Laura M., additional, Canalis, Ernesto, additional, Cao, Xu, additional, Carmeliet, Geert, additional, Carpenter, Thomas O., additional, Chang, Wenhan, additional, Chim, Shek Man, additional, Choudhary, Shilpa, additional, Christakos, Sylvia, additional, Chun, Yong-Hee Patricia, additional, Cipriani, Cristiana, additional, Civitelli, Roberto, additional, Clemens, Thomas L., additional, Collins, Michael T., additional, Conte, Caterina, additional, Cooper, Mark S., additional, Cornish, Jillian, additional, Cremers, Serge, additional, Dawson-Hughes, Bess, additional, de Crombrugghe, Benoit, additional, DeLuca, Hector F., additional, Dempster, David W., additional, Drake, Matthew T., additional, Ducy, Patricia, additional, Ebetino, Frank H., additional, Engelke, Klaus, additional, Erben, Reinhold G., additional, Eyre, David R., additional, Farber, Charles R., additional, Feigenson, Marina, additional, Ferron, Mathieu, additional, Florenzano, Pablo, additional, Fontana, Francesca, additional, Foster, Brian L., additional, Friedman, Peter A., additional, Fukumoto, Seiji, additional, Gamer, Laura W., additional, Gardella, Thomas J., additional, Garnero, Patrick, additional, Genant, Harry K., additional, Giusti, Francesca, additional, Göbel, Andy, additional, Goltzman, David, additional, Gorski, Jeffrey P., additional, Griffith, James, additional, G Russell, R. Graham, additional, Hankenson, Kurt D., additional, Hannan, Fadil M., additional, Harris, Stephen E., additional, Hartley, Iris R., additional, Hartmann, Christine, additional, Heaney, Robert P., additional, Hendy, Geoffrey N., additional, Hilton, Matthew J., additional, Hofbauer, Lorenz C., additional, Holdsworth, Gill, additional, Hsu, Yi-Hsiang, additional, Hudson, David M., additional, Hurley, Marja, additional, Insogna, Karl L., additional, Jilka, Robert L., additional, Johnson, Mark L., additional, Johnson, Rachelle W., additional, Jones, Glenville, additional, Judex, Stefan, additional, Jüppner, Harald, additional, Kalajzic, Ivo, additional, Karsenty, Gérard, additional, Ke, Hua Zhu, additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Klein-Nulend, J., additional, Ko, Frank C., additional, Kobayashi, Yasuhiro, additional, Konrad, Martin, additional, Kostenuik, Paul J., additional, Kovacs, Christopher S., additional, Kremer, Richard, additional, Krishnan, Venkatesh, additional, Kronenberg, Henry M., additional, Lakatos, Peter A., additional, Liberman, Uri A., additional, Lorenzo, Joseph A., additional, Lynch, Conor C., additional, Lyons, Karen M., additional, Ma, Y. Linda, additional, Maes, Christa, additional, Mannstadt, Michael, additional, Manolagas, Stavros, additional, Marcus, Robert, additional, Maridas, David E., additional, Marie, Pierre J., additional, Marini, Francesca, additional, Markovac, Jasna, additional, Martin, T. John, additional, Matthews, Brya G., additional, Maurizi, Antonio, additional, Mirfakhraee, Sasan, additional, Moe, Sharon M., additional, Monroe, David G., additional, Moreira, Carolina A., additional, Müller, Ralph, additional, Musson, David S., additional, Nakatani, Teruyo, additional, Naot, Dorit, additional, Napoli, Nicola, additional, Naveh-Many, Tally, additional, Nemeth, Edward F., additional, Nickolas, Thomas L., additional, Ominsky, Michael S., additional, Ono, Noriaki, additional, Ornitz, David M., additional, Partridge, Nicola C., additional, Patel, Vihitaben S., additional, Pike, J. Wesley, additional, Pilbeam, Carol, additional, Plum, Lori, additional, Potts, John T., additional, Puzas, J. Edward, additional, Rachner, Tilman D., additional, Rakian, Audrey, additional, Rakian, Rubie, additional, Renthal, Nora E., additional, Rhoades (Sterling), Julie A., additional, Riminucci, Mara, additional, Roberts, Scott J., additional, Robey, Pamela Gehron, additional, Rogers, Michael J., additional, Roodman, G. David, additional, Rosen, Clifford J., additional, Rosen, Vicki, additional, Rowe, David W., additional, Rubin, Janet, additional, Rubin, Clinton T., additional, Schlingmann, Karl P., additional, Seeman, Ego, additional, Seibel, Markus J., additional, Sempos, Chris, additional, Shoback, Dolores M., additional, Silve, Caroline, additional, Silver, Justin, additional, Sims, Natalie A., additional, Singer, Frederick R., additional, Stains, Joseph P., additional, Stegen, Steve, additional, Stern, Paula H., additional, Tabacco, Gaia, additional, Takacs, Istvan, additional, Takahashi, Naoyuki, additional, Tay, Donovan, additional, Teti, Anna, additional, Thakker, Rajesh V., additional, Tomlinson, Ryan E., additional, Tonelli, Francesco, additional, Towler, Dwight A., additional, Tsourdi, Elena, additional, Tu, Chia-Ling, additional, Udagawa, Nobuyuki, additional, Weaver, Connie M., additional, Wein, Marc N., additional, Weinstein, Lee S., additional, Weis, MaryAnn, additional, Whyte, Michael P., additional, Williams, Bart O., additional, Xu, Xin, additional, Yakar, Shoshana, additional, Yang, Yingzi, additional, Zanotti, Stefano, additional, and Zhou, Hong, additional

Published
2020
Full Text
View/download PDF

44. Definitions

Author

Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, McKay, James, Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, and McKay, James

Published
2012
Full Text
View/download PDF

46. International Comparisons

Author

Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, McKay, James, Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, and McKay, James

Published
2012
Full Text
View/download PDF

47. The Impact of NGOs

Author

Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, McKay, James, Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, and McKay, James

Published
2012
Full Text
View/download PDF

49. Membership and Volunteering

Author

Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, McKay, James, Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, and McKay, James

Published
2012
Full Text
View/download PDF

50. Key Players

Author

Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, McKay, James, Hilton, Matthew, Crowson, Nick, Mouhot, Jean-François, and McKay, James

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results