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1. Sedentary behavior and physical activity one year after colorectal cancer diagnosis: results from the ColoCare Study

Author

Viskochil, Richard H., Lin, Tengda, Gigic, Biljana, Himbert, Caroline, Bandera, Victoria M., Skender, Stephanie, Holowatyj, Andreana N., Schrotz-King, Petra, Steindorf, Karen, Strehli, Ildiko, Mutch, Matthew G., Chao, Dante, Toriola, Adetunji T., Shibata, David, Siegel, Erin M., Li, Christopher I., Hardikar, Sheetal, Peoples, Anita R., Figueiredo, Jane C., Schneider, Martin, Ulrich, Cornelia M., and Ose, Jennifer

Published
2025
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2. Risk factors and health behaviors associated with loneliness among cancer survivors during the COVID-19 pandemic

Author

Aßmann, Elena S., Ose, Jennifer, Hathaway, Cassandra A., Oswald, Laura B., Hardikar, Sheetal, Himbert, Caroline, Chellam, Vimalkumar, Lin, Tengda, Daniels, Bailee, Kirchhoff, Anne C., Gigic, Biljana, Grossman, Douglas, Tward, Jonathan, Varghese, Jr., Thomas K., Shibata, David, Figueiredo, Jane C., Toriola, Adetunji T., Beck, Anna, Scaife, Courtney, Barnes, Christopher A., Matsen, Cindy, Ma, Debra S., Colman, Howard, Hunt, Jason P., Jones, Kevin B., Lee, Catherine J., Larson, Mikaela, Onega, Tracy, Akerley, Wallace L., Li, Christopher I., Grady, William M., Schneider, Martin, Dinkel, Andreas, Islam, Jessica Y., Gonzalez, Brian D., Otto, Amy K., Penedo, Frank J., Siegel, Erin M., Tworoger, Shelley S., Ulrich, Cornelia M., and Peoples, Anita R.

Published
2024
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4. Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset

Author

Himbert, Caroline, Figueiredo, Jane C, Shibata, David, Ose, Jennifer, Lin, Tengda, Huang, Lyen C, Peoples, Anita R, Scaife, Courtney L, Pickron, Bartley, Lambert, Laura, Cohan, Jessica N, Bronner, Mary, Felder, Seth, Sanchez, Julian, Dessureault, Sophie, Coppola, Domenico, Hoffman, David M, Nasseri, Yosef F, Decker, Robert W, Zaghiyan, Karen, Murrell, Zuri A, Hendifar, Andrew, Gong, Jun, Firoozmand, Eiman, Gangi, Alexandra, Moore, Beth A, Cologne, Kyle G, El-Masry, Maryliza S, Hinkle, Nathan, Monroe, Justin, Mutch, Matthew, Bernadt, Cory, Chatterjee, Deyali, Sinanan, Mika, Cohen, Stacey A, Wallin, Ulrike, Grady, William M, Lampe, Paul D, Reddi, Deepti, Krane, Mukta, Fichera, Alessandro, Moonka, Ravi, Herpel, Esther, Schirmacher, Peter, Kloor, Matthias, von Knebel-Doeberitz, Magnus, Nattenmueller, Johanna, Kauczor, Hans-Ulrich, Swanson, Eric, Jedrzkiewicz, Jolanta, Schmit, Stephanie L, Gigic, Biljana, Ulrich, Alexis B, Toriola, Adetunji T, Siegel, Erin M, Li, Christopher I, Ulrich, Cornelia M, and Hardikar, Sheetal

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Digestive Diseases, Colo-Rectal Cancer, Clinical Research, cohort, colorectal cancer, early onset, epidemiology, Oncology and carcinogenesis
Abstract

Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (

Published
2021

5. Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes

Author

Himbert, Caroline, Ose, Jennifer, Gigic, Biljana, Viskochil, Richard, Santuci, Kelly, Lin, Tengda, Ashworth, Anjelica, Cohan, Jessica N., Scaife, Courtney L., Jedrzkiewicz, Jolanta, Damerell, Victoria, Atkins, Katelyn M., Gong, Jun, Mutch, Matthew G., Bernadt, Corey, Felder, Seth, Sanchez, Julian, Cohen, Stacey A., Krane, Mukta K., Hinkle, Nathan, Wood, Elizabeth, Peoples, Anita R., Figueiredo, Jane C., Toriola, Adetunji T., Siegel, Erin M., Li, Christopher I., Shibata, David, Boucher, Kenneth, Round, June L., Ulrich, Alexis B., Schneider, Martin, Huang, Lyen C., Hardikar, Sheetal, and Ulrich, Cornelia M.

Published
2023
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7. Factors associated with changes in exercise behaviors during the COVID-19 pandemic

Author

Himbert, Caroline, Hathaway, Cassandra A., Daniels, Bailee, Salas, Karen, Ashworth, Anjelica, Gigic, Biljana, Lin, Tengda, Viskochil, Richard, Kirchhoff, Anne C., Grossman, Douglas, Ose, Jennifer, Tward, Jonathan, Scaife, Courtney, Figueiredo, Jane C., Toriola, Adetunji T., Beck, Anna, Shibata, David, Gonzalez, Brian D., Matsen, Cindy, Christenson, Cristina, Ma, Debra S., Colman, Howard, Hunt, Jason P., Jones, Kevin B., Lee, Catherine J., Larson, Mikaela, Onega, Tracy, Akerley, Wallace L., Li, Christopher I., Schneider, Martin, Penedo, Frank J., Siegel, Erin M., Tworoger, Shelley S., Ulrich, Cornelia M., and Peoples, Anita R.

Published
2022
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8. Comparison of risk factors, treatment strategy, and outcomes of early- vs. older-onset colorectal cancer within the prospective ColoCare study.

Author

Gottschalk, Zachary, Redman, Mary Weber, Baker, Kelsey K., Gigic, Biljana, Damerell, Victoria, Loroña, Nicole C., Ulrich, Cornelia M, Siegel, Erin M., Figueiredo, Jane, Shibata, David, Toriola, Adetunji T., Byrd, Doratha, Ilozumba, Mmadili, Erickson, Patricia, Himbert, Caroline, Lin, Tengda, Ose, Jennifer, Hardikar, Sheetal, Li, Christopher I., and Cohen, Stacey A.

Published
2025
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9. Alcohol Consumption and Smoking History at the Time of Diagnosis and the Risk of Colorectal Cancer Recurrence and Mortality: Results from the ColoCare Study.

Author

Loroña, Nicole C., Himbert, Caroline, Ose, Jennifer, Cohen, Stacey A., Strehli, Ildiko, Ulrich, Cornelia M., Cobos, Sofia, Jean-Baptiste, Esther, Bloomer, Amanda M., Figueiredo, Jane C., Gigic, Biljana, Hardikar, Sheetal, Karchi, Meghana, Mutch, Matthew, Peoples, Anita R., Schneider, Martin, Shibata, David, Siegel, Erin M., Toriola, Adetunji T., and Wood, Elizabeth H.

Abstract

Background: Findings from studies investigating the impacts of alcohol use and smoking on colorectal cancer outcomes are inconclusive. This study aimed to investigate associations between alcohol use and smoking status at the time of diagnosis on recurrence and overall mortality among patients with colorectal cancer. Methods: The present study included 2,216 stage I-IV patients with colorectal cancer from the longitudinal multicenter ColoCare Study, with available data on recurrence and colorectal cancer-specific mortality. Cox proportional hazards models adjusted for age, sex, race, ethnicity, stage, tumor site, treatment, comorbidities, body mass index, and study site were fit, with imputations for missing data. Results: We observed 235 recurrences and 308 colorectal cancer-specific deaths over an average of 3 years of follow-up. After adjusting for confounders, current alcohol consumption and ever smoking, relative to not current consumption and never smoking, respectively, were not statistically significantly associated with colorectal cancer recurrence [alcohol--HR, 0.95. 95% confidence interval (CI), 0.71-1.29; ever smoking--HR, 0.98, 95% CI, 0.75-1.29] or colorectal cancer-specific mortality (alcohol--HR, 0.95. 95% CI, 0.74-1.22; ever smoking--HR, 0.98, 95% CI, 0.77-1.24). Conclusions: No associations were observed between alcohol and smoking at diagnosis and clinical outcomes in this well-annotated longitudinal cohort. Impact: Our cohort study reports no significant associations; however, limiting alcohol use and avoiding smoking are health behaviors recommended for colorectal cancer survivors for prevention of other cancers and chronic conditions. [ABSTRACT FROM AUTHOR]

Published
2025
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10. Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients : results from the ColoCare study

Author

Ose, Jennifer, Holowatyj, Andreana N., Nattenmüller, Johanna, Gigic, Biljana, Lin, Tengda, Himbert, Caroline, Habermann, Nina, Achaintre, David, Scalbert, Augustin, Keski-Rahkonen, Pekka, Böhm, Jürgen, Schrotz-King, Petra, Schneider, Martin, Ulrich, Alexis, Kampman, Ellen, Weijenberg, Matty, Gsur, Andrea, Ueland, Per-Magne, Kauczor, Hans-Ulrich, and Ulrich, Cornelia M.

Published
2020

12. Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis

Author

Achaintre, David, Brezina, Stefanie, van Duijnhoven, Franzel J.B., Gsur, Andrea, Keski-Rahkonen, Pekka, Weijenberg, Matty P., Abbenhardt-Martin, Clare, Boehm, Juergen, Boucher, Kenneth, Habermann, Nina, Haffa, Mariam, Hardikar, Sheetal, Himbert, Caroline, Kauczor, Hans-Ulrich, Kloor, Matthias, Lampe, Paul D., Lin, Tengda, Ose, Jennifer, Scherer, Dominique, Schirmacher, Peter, Schrotz-King, Petra, von Knebel-Doeberitz, Magnus, Warby, Christy A., Zhang, Yuzheng, Ulrich, Alexis B., Swanson, Eric A., Tavtigian, Sean V., Holowatyj, Andreana N., Gigic, Biljana, Herpel, Esther, Scalbert, Augustin, Schneider, Martin, and Ulrich, Cornelia M.

Published
2020
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14. Relationships Among Physical Activity, Sleep, and Cancer-related Fatigue: Results From the International ColoCare Study

Author

Crowder, Sylvia L, primary, Li, Xiaoyin, additional, Himbert, Caroline, additional, Viskochil, Richard, additional, Hoogland, Aasha I, additional, Gudenkauf, Lisa M, additional, Oswald, Laura B, additional, Gonzalez, Brian D, additional, Small, Brent J, additional, Ulrich, Cornelia M, additional, Ose, Jennifer, additional, Peoples, Anita R, additional, Li, Christopher I, additional, Shibata, David, additional, Toriola, Adetunji T, additional, Gigic, Biljana, additional, Playdon, Mary C, additional, Hardikar, Sheetal, additional, Bower, Julienne, additional, Siegel, Erin M, additional, Figueiredo, Jane C, additional, and Jim, Heather S L, additional

Published
2023
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16. Pre‐emptive treatment of heart failure exacerbations in patients managed with the HeartLogic™ algorithm.

Author

Garcia, Rodrigue, Gras, Daniel, Mansourati, Jacques, Defaye, Pascal, Bisson, Arnaud, Boveda, Serge, Gandjbakhch, Estelle, Gras, Matthieu, Gueffet, Jean‐Pierre, Himbert, Caroline, Jacon, Peggy, Khattar, Pierre, Lequeux, Benoit, Li, Anthony, Mansourati, Vincent, Minois, Damien, Marijon, Eloi, Pierre, Bertrand, Probst, Vincent, and Degand, Bruno

Subjects
VENTRICULAR ejection fraction, HEART failure patients, TREATMENT failure, ATRIAL arrhythmias, VENTRICULAR arrhythmia, ARTIFICIAL implants
Abstract

Aims: Heart failure (HF) is a chronic disease affecting 64 million people worldwide and places a severe burden on society because of its mortality, numerous re‐hospitalizations and associated costs. HeartLogic™ is an algorithm programmed into implanted devices incorporating several biometric parameters which aims to predict HF episodes. It provides an index which can be monitored remotely, allowing pre‐emptive treatment of congestion to prevent acute decompensation. We aim to assess the impact and security of pre‐emptive HF management, guided by the HeartLogic™ index. Methods and results: The HeartLogic™ France Cohort Study is an investigator‐initiated, prospective, multi‐centre, non‐randomized study. Three hundred ten patients with a history of HF (left ventricular ejection fraction ≤40%; or at least one episode of clinical HF with elevated NT‐proBNP ≥450 ng/L) and implanted with a cardioverter defibrillator enabling HeartLogic™ index calculation will be included across 10 French centres. The HeartLogic™ index will be monitored remotely for 12 months and in the event of a HeartLogic™ index ≥16, the local investigator will contact the patient for assessment and adjust HF treatment as necessary. The primary endpoint is unscheduled hospitalization for HF. Secondary endpoints are all‐cause mortality, cardiovascular death, HF‐related death, unscheduled hospitalizations for ventricular or atrial arrhythmia and HeartLogic™ index evolution over time. Blood samples will be collected for biobanking, and quality of life will be assessed. Finally, the safety of a HeartLogic™‐triggered strategy for initiating or increasing diuretic therapy will be assessed. A blind and independent committee will adjudicate the events. Conclusions: The HeartLogic™ France Cohort Study will provide robust real‐world data in a cohort of HF patients managed with the HeartLogic™ algorithm allowing pre‐emptive treatment of heart failure exacerbations. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Physical Activity In Colorectal Cancer Patients 12 Months After Resection: Results From The Colocare Study: 1245 Board #371 May 27 2:30 PM - 4:00 PM

Author

Viskochil, Richard, Gigic, Biljana, Skender, Stephanie, Bohm, Jurgen, Steindorf, Karen, Owen, Robert, Holowatyj, Andreana, Himbert, Caroline, Lin, Tengda, Peoples, Anita, Hardikar, Sheetal, Figueiredo, Jane, Li, Christopher, Siegel, Erin, Toriola, Adetunji, Shibata, David, Schneider, Martin, Ulrich, Alexis, Ose, Jennifer, and Ulrich, Cornelia M.

Published
2020
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21. Relationships Among Physical Activity, Sleep, and Cancer-related Fatigue: Results From the International ColoCare Study.

Author

Crowder, Sylvia L, Li, Xiaoyin, Himbert, Caroline, Viskochil, Richard, Hoogland, Aasha I, Gudenkauf, Lisa M, Oswald, Laura B, Gonzalez, Brian D, Small, Brent J, Ulrich, Cornelia M, Ose, Jennifer, Peoples, Anita R, Li, Christopher I, Shibata, David, Toriola, Adetunji T, Gigic, Biljana, Playdon, Mary C, Hardikar, Sheetal, Bower, Julienne, and Siegel, Erin M

Subjects
PHYSICAL activity, CANCER fatigue, SLEEP, FATIGUE (Physiology), HEALTH behavior, CANCER patients, POLYSOMNOGRAPHY
Abstract

Background Risk factors for cancer-related fatigue are understudied in colorectal cancer. Purpose This study aimed to address this critical gap in the literature by (a) describing changes in colorectal cancer-related fatigue and health behavior (physical activity, sleep problems) and (b) examining if physical activity and sleep problems predict fatigue trajectories from baseline (approximately at the time of diagnosis), to 6- and 12 months after enrollment. Methods Patients participating in the international ColoCare Study completed self-report measures at baseline (approximately time of diagnosis), 6-, and 12 months assessing physical activity using the International Physical Activity Questionnaire (IPAQ) and fatigue and sleep using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30). Mixed-effect models examined changes in physical activity, sleep problems, and fatigue. Cross-lagged panel models examined bidirectional relationships between physical activity or sleep and fatigue across time. Results Colorectal cancer patients (n = 649) had a mean age of 61 ± 13 years. Most were male (59%), non-Hispanic White (91%), diagnosed with Stages III–IV (56%) colon cancer (58%), and treated with surgery (98%). Within-person cross-lagged models indicated higher physical activity at Month 6 was associated with higher fatigue at Month 12 (β = 0.26, p =.016). When stratified by cancer stage (I–II vs. III–IV), the relationship between physical activity at Month 6 and fatigue at Month 12 existed only for patients with advanced cancer (Stages III and IV, β = 0.43, p =.035). Cross-lagged associations for sleep and fatigue from baseline to Month 6 were only observed in patients with Stages III or IV cancer, however, there was a clear cross-sectional association between sleep problems and fatigue at baseline and Month 6. Conclusions Within-person and cross-lagged association models suggest fatiguability may become increasingly problematic for patients with advanced colorectal cancer the first year after diagnosis. In addition, sleep problems were consistently associated with higher fatigue in the first year, regardless of cancer stage. Trial registration The international ColoCare Study was registered on clinicaltrials.gov, NCT02328677, in December 2014. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients

Author

Himbert, Caroline, primary, Warby, Christy A., primary, Gigic, Biljana, primary, Ose, Jennifer, primary, Lin, Tengda, primary, Viskochil, Richard, primary, Peoples, Anita R., primary, Ashworth, Anjelica, primary, Schrotz-King, Petra, primary, Scaife, Courtney L., primary, Cohan, Jessica N., primary, Jedrzkiewicz, Jolanta, primary, Schirmacher, Peter, primary, Grady, William M., primary, Cohen, Stacey A., primary, Krane, Mukta, primary, Figueiredo, Jane C., primary, Toriola, Adetunji T., primary, Siegel, Erin M., primary, Shibata, David, primary, Round, June L., primary, Huang, Lyen C., primary, Li, Christopher I., primary, Schneider, Martin, primary, Ulrich, Alexis, primary, Hardikar, Sheetal, primary, and Ulrich, Cornelia M., primary

Published
2023
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23. Supplementary Data from Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients

Author

Himbert, Caroline, primary, Warby, Christy A., primary, Gigic, Biljana, primary, Ose, Jennifer, primary, Lin, Tengda, primary, Viskochil, Richard, primary, Peoples, Anita R., primary, Ashworth, Anjelica, primary, Schrotz-King, Petra, primary, Scaife, Courtney L., primary, Cohan, Jessica N., primary, Jedrzkiewicz, Jolanta, primary, Schirmacher, Peter, primary, Grady, William M., primary, Cohen, Stacey A., primary, Krane, Mukta, primary, Figueiredo, Jane C., primary, Toriola, Adetunji T., primary, Siegel, Erin M., primary, Shibata, David, primary, Round, June L., primary, Huang, Lyen C., primary, Li, Christopher I., primary, Schneider, Martin, primary, Ulrich, Alexis, primary, Hardikar, Sheetal, primary, and Ulrich, Cornelia M., primary

Published
2023
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24. Supplementary Table from Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer

Author

Bowers, Laura W., primary, Glenny, Elaine M., primary, Punjala, Arunima, primary, Lanman, Nadia A., primary, Goldbaum, Audrey, primary, Himbert, Caroline, primary, Montgomery, Stephanie A., primary, Yang, Peiying, primary, Roper, Jatin, primary, Ulrich, Cornelia M., primary, Dannenberg, Andrew J., primary, Coleman, Michael F., primary, and Hursting, Stephen D., primary

Published
2023
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25. Supplementary Figure from Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer

Author

Bowers, Laura W., primary, Glenny, Elaine M., primary, Punjala, Arunima, primary, Lanman, Nadia A., primary, Goldbaum, Audrey, primary, Himbert, Caroline, primary, Montgomery, Stephanie A., primary, Yang, Peiying, primary, Roper, Jatin, primary, Ulrich, Cornelia M., primary, Dannenberg, Andrew J., primary, Coleman, Michael F., primary, and Hursting, Stephen D., primary

Published
2023
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26. Additional file 1 of Associations of combined physical activity and body mass index groups with colorectal cancer survival outcomes

Author

Himbert, Caroline, Ose, Jennifer, Gigic, Biljana, Viskochil, Richard, Santuci, Kelly, Lin, Tengda, Ashworth, Anjelica, Cohan, Jessica N., Scaife, Courtney L., Jedrzkiewicz, Jolanta, Damerell, Victoria, Atkins, Katelyn M., Gong, Jun, Mutch, Matthew G., Bernadt, Corey, Felder, Seth, Sanchez, Julian, Cohen, Stacey A., Krane, Mukta K., Hinkle, Nathan, Wood, Elizabeth, Peoples, Anita R., Figueiredo, Jane C., Toriola, Adetunji T., Siegel, Erin M., Li, Christopher I., Shibata, David, Boucher, Kenneth, Round, June L., Ulrich, Alexis B., Schneider, Martin, Huang, Lyen C., Hardikar, Sheetal, and Ulrich, Cornelia M.

Abstract

Additional file 1: Supplementary Table S1. Cox proportional hazard models of physical activity quartiles with overall and disease-free survival in colorectal cancer patients. Supplementary Table S2. Cox proportional hazard models of combined physical activity (8.75 MET hrs/wk threshold) and BMI groups with overall and disease-free survival in colorectal cancer patients. Supplementary Table S3. Baseline study population characteristics by completed and missing physical activity data [n (%) if not otherwise stated]. Supplementary Figure S1. Individual and combined physical activity and BMI groups.

Published
2023
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27. Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study

Author

Lindley, Clara L., primary, Gigic, Biljana, additional, Peoples, Anita R., additional, Han, Claire J., additional, Lin, Tengda, additional, Himbert, Caroline, additional, Warby, Christy A., additional, Boehm, Juergen, additional, Hardikar, Sheetal, additional, Ashworth, Anjelica, additional, Schneider, Martin, additional, Ulrich, Alexis, additional, Schrotz-King, Petra, additional, Figueiredo, Jane C., additional, Li, Christopher I., additional, Shibata, David, additional, Siegel, Erin M., additional, Toriola, Adetunji T., additional, Ulrich, Cornelia M., additional, Syrjala, Karen L., additional, and Ose, Jennifer, additional

Published
2023
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28. Abstract P010: Molecular mediators of the energy balance-colorectal cancer link: evaluating the gut microbiome and pro-inflammatory biomarkers

Author

Himbert, Caroline, primary, Stephens, W. Zac, additional, Gigic, Biljana, additional, Lin, Tengda, additional, Ose, Jennifer, additional, Ashworth, Anjelica, additional, Warby, Christy, additional, Nix, David, additional, Jedrzkiewicz, Jolanta, additional, Peoples, Anita R, additional, Bronner, Mary, additional, Pickron, Bartley, additional, Scaife, Courtney, additional, Cohan, Jessica N., additional, Grady, William M., additional, Cohen, Stacey A., additional, Krane, Mukta, additional, Schrotz-King, Petra, additional, Figueiredo, Jane C., additional, Toriola, Adetunji T., additional, Siegel, Erin M., additional, Li, Christopher I., additional, Ulrich, Alexis, additional, Shibata, David, additional, Round, June L., additional, Huang, Lyen C., additional, Schneider, Martin, additional, Hardikar, Sheetal, additional, and Ulrich, Cornelia M, additional

Published
2023
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29. Differences in the gut microbiome by physical activity and BMI among colorectal cancer patients

Author

Himbert, Caroline, Stephens, W Zac, Gigic, Biljana, Hardikar, Sheetal, Holowatyj, Andreana N, Lin, Tengda, Ose, Jennifer, Swanson, Eric, Ashworth, Anjelica, Warby, Christy A, Peoples, Anita R, Nix, David, Jedrzkiewicz, Jolanta, Bronner, Mary, Pickron, Bartley, Scaife, Courtney, Cohan, Jessica N, Schrotz-King, Petra, Habermann, Nina, Boehm, Juergen, Hullar, Meredith, Figueiredo, Jane C, Toriola, Adetunji T, Siegel, Erin M, Li, Christopher I, Ulrich, Alexis B, Shibata, David, Boucher, Kenneth, Huang, Lyen C, Schneider, Martin, Round, June L, and Ulrich, Cornelia M

Subjects
Original Article
Abstract

Associations of energy balance components, including physical activity and obesity, with colorectal cancer risk and mortality are well established. However, the gut microbiome has not been investigated as underlying mechanism. We investigated associations of physical activity, BMI, and combinations of physical activity/BMI with gut microbiome diversity and differential abundances among colorectal cancer patients. N=179 patients with colorectal cancer (stages I-IV) were included in the study. Pre-surgery stool samples were used to perform 16S rRNA gene sequencing (Illumina). Physical activity (MET hrs/wk) during the year before diagnosis was assessed by questionnaire and participants were classified as being active vs. inactive based on guidelines. BMI at baseline was abstracted from medical records. Patients were classified into four combinations of physical activity levels/BMI. Lower gut microbial diversity was observed among ‘inactive’ vs. ‘active’ patients (Shannon: P=0.01, Simpson: P=0.03), ‘obese’ vs. ‘normal weight’ patients (Shannon, Simpson, and Observed species: P=0.02, respectively), and ‘overweight/obese/inactive’ vs. ‘normal weight/active’ patients (Shannon: P=0.02, Observed species: P=0.04). Results differed by sex and tumor site. Two phyla and 12 genera (Actinobacteria and Fusobacteria, Adlercreutzia, Anaerococcus, Clostridium, Eubacterium, Mogibacteriaceae, Olsenella, Peptinophilus, Pyramidobacter, RFN20, Ruminococcus, Succinivibrio, Succiniclasticum) were differentially abundant across physical activity and BMI groups. This is the first evidence for associations of physical activity with gut microbiome diversity and abundances, directly among colorectal cancer patients. Our results indicate that physical activity may offset gut microbiome dysbiosis due to obesity. Alterations in gut microbiota may contribute mechanistically to the energy balance-colorectal cancer link and impact clinical outcomes.

Published
2022

30. Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients

Author

Himbert, Caroline, primary, Warby, Christy A., additional, Gigic, Biljana, additional, Ose, Jennifer, additional, Lin, Tengda, additional, Viskochil, Richard, additional, Peoples, Anita R., additional, Ashworth, Anjelica, additional, Schrotz-King, Petra, additional, Scaife, Courtney L., additional, Cohan, Jessica N., additional, Jedrzkiewicz, Jolanta, additional, Schirmacher, Peter, additional, Grady, William M., additional, Cohen, Stacey A., additional, Krane, Mukta, additional, Figueiredo, Jane C., additional, Toriola, Adetunji T., additional, Siegel, Erin M., additional, Shibata, David, additional, Round, June L., additional, Huang, Lyen C., additional, Li, Christopher I., additional, Schneider, Martin, additional, Ulrich, Alexis, additional, Hardikar, Sheetal, additional, and Ulrich, Cornelia M., additional

Published
2022
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31. Longitudinal Changes To Objectively Measured Physical Activity And Sedentary Behavior In Colorectal Cancer Survivors

Author

Viskochil, Richard, primary, Ashworth, Anjelica, additional, Lin, Tengda, additional, Himbert, Caroline, additional, Holowatyj, Andreana, additional, Peoples, Anita, additional, Hardikar, Sheetal, additional, Toriola, Adetunji, additional, Gigic, Biljana, additional, Shibata, David, additional, Li, Christopher, additional, Figueiredo, Jane, additional, Siegel, Erin, additional, Schneider, Martin, additional, Ulrich, Cornelia, additional, and Ose, Jennifer, additional

Published
2022
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32. Abstract 3227: Prognostic role of systemic inflammation in colon and rectal cancer patients: Results from the ColoCare Study

Author

Ose, Jennifer, primary, Lin, Tengda, additional, Himbert, Caroline, additional, Warby, Christy A., additional, Hardikar, Sheetal, additional, Boehm, Juergen, additional, Gigic, Biljana, additional, Schrotz-King, Petra, additional, Schneider, Martin, additional, Ulrich, Alexis B., additional, Shibata, David, additional, Figueiredo, Jane C., additional, Siegel, Erin M., additional, Li, Christopher I., additional, Toriola, Adetunji T., additional, and Ulrich, Cornelia M., additional

Published
2022
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33. Abstract 3221: Differences in body composition among rectal cancer patients with neo-adjuvant treatment-related toxicity: Results from the ColoCare Study

Author

Ose, Jennifer, primary, Yap, Jeffrey T., additional, Jeong, Daniel, additional, Van, Simon Ta, additional, Covington, Matthew F., additional, Gigic, Biljana, additional, Nattenmueller, Johanna, additional, Haaland, Benjamin, additional, Lin, Tengda, additional, Hardikar, Sheetal, additional, Himbert, Caroline, additional, Peoples, Anita R., additional, Ashworth, Anjelica, additional, Boehm, Juergen, additional, Schrotz-King, Petra, additional, Figueiredo, Jane C., additional, Toriola, Adetunji T., additional, Siegel, Erin M., additional, Li, Christopher I., additional, Ulrich, Alexis B., additional, Schneider, Martin, additional, Kauczor, Hans-Ulrich, additional, Shibata, David, additional, and Ulrich, Cornelia M., additional

Published
2022
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34. Presurgery Adhesion Molecules and Angiogenesis Biomarkers Are Differently Associated with Outcomes in Colon and Rectal Cancer: Results from the ColoCare Study

Author

Ose, Jennifer, primary, Gigic, Biljana, additional, Hardikar, Sheetal, additional, Lin, Tengda, additional, Himbert, Caroline, additional, Warby, Christy A., additional, Peoples, Anita R., additional, Lindley, Clara L., additional, Boehm, Juergen, additional, Schrotz-King, Petra, additional, Figueiredo, Jane C., additional, Toriola, Adetunji T., additional, Siegel, Erin M., additional, Li, Christopher I., additional, Ulrich, Alexis, additional, Schneider, Martin, additional, Shibata, David, additional, and Ulrich, Cornelia M., additional

Published
2022
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35. Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer

Author

Bowers, Laura W., primary, Glenny, Elaine M., additional, Punjala, Arunima, additional, Lanman, Nadia A., additional, Goldbaum, Audrey, additional, Himbert, Caroline, additional, Montgomery, Stephanie A., additional, Yang, Peiying, additional, Roper, Jatin, additional, Ulrich, Cornelia M., additional, Dannenberg, Andrew J., additional, Coleman, Michael F., additional, and Hursting, Stephen D., additional

Published
2022
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36. Sa1080: AN EVALUATION OF THE ASSOCIATION BETWEEN INFLAMMATION-ASSOCIATED BIOMARKERS AND MICROSATELLITE INSTABLILITY IN COLORECTAL CANCER

Author

Loomans-Kropp, Holli A., primary, Umar, Asad, additional, Ose, Jennifer, additional, Lin, Tengda, additional, Himbert, Caroline, additional, Warby, Christy A., additional, Ashworth, Anjelica, additional, Hardikar, Sheetal, additional, Bohm, Jurgen, additional, Gigic, Biljana, additional, Schrotz-King, Petra, additional, Zielske, Lin, additional, Schneider, Martin, additional, Ulrich, Alexis B., additional, Shibata, David, additional, Figueiredo, Jane C., additional, Siegel, Erin, additional, Li, Christopher I., additional, Toriola, Adetunji, additional, and Ulrich, Cornelia, additional

Published
2022
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38. Impact of the COVID‐19 pandemic on rural and urban cancer patients' experiences, health behaviors, and perceptions

Author

Peoples, Anita R., primary, Oswald, Laura B., additional, Ose, Jennifer, additional, Daniels, Bailee, additional, Himbert, Caroline, additional, Hathaway, Cassandra A., additional, Gigic, Biljana, additional, Kirchhoff, Anne C., additional, Lin, Tengda, additional, Grossman, Douglas, additional, Tward, Jonathan, additional, Varghese, Thomas K., additional, Figueiredo, Jane C., additional, Toriola, Adetunji T., additional, Beck, Anna, additional, Scaife, Courtney, additional, Shibata, David, additional, LaStayo, Paul, additional, Gonzalez, Brian, additional, Salas, Karen, additional, Ashworth, Anjelica, additional, Matsen, Cindy, additional, Christenson, Cristina, additional, Ma, Debra S., additional, Colman, Howard, additional, Hunt, Jason P., additional, Jones, Kevin B., additional, Lee, Catherine J., additional, Larson, Mikaela, additional, Onega, Tracy, additional, Akerley, Wallace L., additional, Li, Christopher I., additional, Schneider, Martin, additional, Penedo, Frank J., additional, Siegel, Erin M., additional, Tworoger, Shelley S., additional, and Ulrich, Cornelia M., additional

Published
2022
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39. Scaphotrapeziotrapezoid Arthrodesis: Systematic Review

Author

Stephens, Andrew R., primary, Garcia, Brittany N., additional, Rogers, Miranda J., additional, Zhang, Chong, additional, Himbert, Caroline, additional, McFarland, Mary M., additional, Presson, Angela P., additional, Kazmers, Nikolas H., additional, and Tyser, Andrew R., additional

Published
2022
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40. Comparison of right ventricular septal pacing and right ventricular apical pacing in patients receiving cardiac resynchronization therapy defibrillators: the SEPTAL CRT Study

Author

Leclercq, Christophe, Sadoul, Nicolas, Mont, Lluis, Defaye, Pascal, Osca, Joaquim, Mouton, Elisabeth, Isnard, Richard, Habib, Gilbert, Zamorano, Jose, Derumeaux, Genevieve, Fernandez-Lozano, Ignacio, Dupuis, Jean-Marc, Rouleau, Frédéric, Tassin, Aude, Bordachar, Pierre, Clémenty, Jacques, Lafitte, Stephane, Ploux, Sylvan, Reant, Patricia, Ritter, Philippe, Defaye, Pascal, Jacon, Peggy, Mondesert, Blandine, Saunier, Carole, Vautrin, Estelle, Kacet, Salem, Guedon-Moreau, Laurence, Klug, Didier, Kouakam, Claude, Marechaux, Sylvestre, Marquie, Christelle, Polge, Anne Sophie, Richardson, Marjorie, Chevallier, Philippe, De Breyne, Brigitte, Lotek, Marcin M., Nonin, Emilie, Pineau, Julien, Deharo, Jean-Claude, Bastard, Emilie, Franceschi, Frédéric, Habib, Gilbert, Jego, Christophe, Peyrouse, Eric, Prevot, Sebastien, Saint-Joseph, Hôpital, Bremondy, Michel, Faure, Jacques, Ferracci, Ange, Lefevre, Jean, Pisapia, Andre, Davy, Jean-Marc, Cransac, Frederic, Cung, Tien Tri, Georger, Frederic, Pasquie, Jean-Luc, Raczka, Franck, Sportouch-Dukhan, Catherine, Sadoul, Nicolas, Blangy, Hugues, Bruntz, Jean-François, Freysz, Luc, Groben, Laurent, Huttin, Olivier, Bammert, Antoine, Burban, Marc, Cebron, Jean-Pierre, Gras, Daniel, Frank, Robert, Duthoit, Guillaume, Hidden-Lucet, Françoise, Himbert, Caroline, Isnard, Richard, Lacotte, Jérôme, Pousset, Françoise, Zerah, Thierry, Leclercq, Christophe, Bellouin, Annaïk, Crocq, Christophe, Deplace, Christian, Donal, Erwan, Hamon, Cécile, Mabo, Philippe, Romain, Olivier, Solnon, Aude, Frederic, Anselme, Bauer, Fabrice, Bernard, Mathieu, Godin, Benedicte, Kurtz, Baptiste, Savoure, Arnaud, Copie, Xavier, Lascault, Gilles, Paziaud, Olivier, Piot, Olivier, Touche, Thierry, Delay, Toulouse Marc, Chilon, Talia, Detis, Nicolas, Duparc, Alexandre, Hebrard, Aurélien, Massabuau, Pierre, Maury, Philippe, Mondoly, Pierre, Rumeau, Philippe, Pasteur, Clinique, Boveda, Serge, Adrover, Laurence, Combes, Nicolas, Deplagne, Antoine, Marco-Baertich, Isabelle, Fondard, Olivier, Martínez, Juan Gabriel, Ibañez Criado, José Luis, Ortuño, Diego, Mont, Lluis, Berruezo, Antonio, Eduard, Belu, Martín, Ana, Merschon, Franco M., Sitges, Marta, Tolosana, José María, Vidal, Bárbara, Hebron, H. Valle, i Mitjans, Angel Moya, Rodriguez, Oscar Alcalde, Rodriguez Palomares, José Fernando, Rivas, Nuria, Teixidó, Gisela, de Hierro, H. Puerta, Lozano, Ignacio Fernández, Ruiz Bautista, Maria Lorena, Castro, Victor, Cavero, Miguel Angel, Gutierrez, Carlos, Ros, Natalia, de la Victoria, H. Virgen, Alzueta Rodriguez, Francisco Javier, Cabrera, Fernando, Cordero, Alberto Barrera, Peña, José Luis, de Valme Sevilla, H., Gonzáles, Juan Lealdel Ojo, Garcia Medina, M Dolores, Jiménez, Ricardo Pavón, Villagomez, David, de la Salud Toledo, H. Virgen, Castellanos Martinez, Eduardo, Alcalá, Juan, Maicas, Carolina, Arias Palomares, Miguel Angel, Puchol, Alberto, Valencia, H. La Fé, OscaAsensi, Joaquim, Carmona, Anastasio Quesada, De Carranza, M José Sancho-Tello, De Ros, José Olagüe, Pareja, Enrique Castro, Pérez, Oscar Cano, Saez, Ana Osa, Hortega, H. Rio, Guilarte, Benito Herreros, Muñoz San Jose, Juan Francisco, Pérez Sanz, Teresa Myriam, Logeart, Damien, Gil, Maria Lopez, Leclercq, Christophe, Lozano, Ignacio Fernandez, de Hierro, H. Puerta, and Derumeaux, Genevieve

Published
2016
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41. Causes-of-death analysis of patients with cardiac resynchronization therapy: an analysis of the CeRtiTuDe cohort study

Author

Marijon, Eloi, Leclercq, Christophe, Narayanan, Kumar, Boveda, Serge, Klug, Didier, Lacaze-Gadonneix, Jonathan, Defaye, Pascal, Jacob, Sophie, Piot, Olivier, Deharo, Jean-Claude, Perier, Marie-Cecile, Mulak, Genevieve, Hermida, Jean-Sylvain, Milliez, Paul, Gras, Daniel, Cesari, Olivier, Hidden-Lucet, Françoise, Anselme, Frederic, Chevalier, Philippe, Maury, Philippe, Sadoul, Nicolas, Bordachar, Pierre, Cazeau, Serge, Chauvin, Michel, Empana, Jean-Philippe, Jouven, Xavier, Daubert, Jean-Claude, Le Heuzey, Jean-Yves, Le Heuzey, Jean-Yves, Cauchemez, Bruno, Khemache, Alain, Thomas, Olivier, Hermida, Jean-Sylvain, Kubala, Mathieu, Mathiron, Armelle, Traullé, Sarah, Dupuis, Jean-Marc, Foucault, Anthony, Tassin, Aude, Algalarrondo, Vincent, Dinanian, Sylvie, Juin, Christophe, Sebag, Claude, Briand, Florent, Guignier, Alexandre, Janin, Sébastien, Champ-Rigot, Laure, Gomes, Sophie, Milliez, Paul, Pellissier, Arnaud, Scanu, Patrice, Barthez, Olivier, Bertaux-Cattarossi, Géraldine, Duvernay-Debin, Régine, Farnier, Fabien, Laurent, Gabriel, Martel-Bourcier, Alexandra, Defaye, Pascal, Jacon, Peggy, Durand, Cyril, Durand-Dubief, Alexis, Monsarrat, Nicolas, Poty, Hervé, Boulé, Stéphane, Brigadeau, François, Fossati, Frédéric, Guédon-Moreau, Laurence, Jarwe, Mustapha, Kacet, Salem, Klug, Didier, Kouakam, Claude, Lacroix, Dominique, Marquie, Christelle, Blanc, Patrick, Echahidi, Najmeddine, Espaliat, Eric, Guy-Moyat, Benoit, Lesage, Jérôme, Deharo, Jean-Claude, Franceschi, Frédéric, Prévot, Sébastien, Aliot, Etienne, Andronache, Marius, Brembillat Perrot, Béatrice, de Chillou, Christian, Sadoul, Nicolas, Badenco, Nicolas, Chastre, Thomas, Duthoit, Guillaume, Frank, Robert, Gandjbakhch, Estelle, Gartenlaub, Olivier, Hidden-Lucet, Françoise, Himbert, Caroline, Waintraub, Xavier, Zerah, Thierry, Bauley, Karine, Chabert, Jean-Pierre, Deschildre, Alain, Lesaffre, François, Martin, Angéline, Rio, Colette, Daubert, Jean-Claude, Leclercq, Christophe, Mabo, Philippe, Pavin, Dominique, Anselme, Fréderic, Godin, Bénédicte, Savouré, Arnaud, Bisch, Laurence, Da Costa, Antoine, Romeyer, Cécile, Bakou Boula, Babe, Bronner, François, Chauvin, Michel, Douchet, Marie-Pierre, Jesel, Laurence, Marzak, Halim, Schatz, Alexandre, Cardin, Christelle, Chilon, Talia, Delay, Marc, Duparc, Alexandre, Garderes-Rollin, Anne, Maury, Philippe, Mondoly, Pierre, Somody, Elisabeth, Thomson, Emile, Chevalier, Philippe, Dulac, Arnaud, Mlotek, Marcin, Nonin-Babary, Emilie, Jouven, Xavier, Lavergne, Thomas, Le Heuzey, Jean-Yves, Marijon, Eloi, Otmani, Akli, Burban, Marc, Cebron, Jean-Pierre, Gras, Daniel, Barraud, Pascal, Langlade, Stéphane, Lipiecki, Janusz, Philippot, François, Richard, Alain, Robin, Isabelle, Schandrin, Christian, Vacher, Dominique, Cardin, Christelle, Reza Rezaei, Mohammed, Rumeau, Philippe, Fouché, Renaud, Fromentin, Stéphane, Khattar, Pierre, Le Potier, Jacques, Mouhid, Jamal, Palud, Laurent, Andres, Henri, Boureux, Christian, Chopat, Patrick, Nadji, Georges, Sultan, Pierre, Targosz, Frédéric, Doazan, Jean-Philippe, El Hajjaji, Nourédine, Hannachi, Sofiene, Noblemaire, Romain, Somody, Elisabeth, Copie, Xavier, Lascault, Gilles, Paziaud, Olivier, Piot, Olivier, Billon, Olivier, Gully, Claude, Haddad, Georges, Lipp, Damien, Mouhoub, Driss, Bru, Paul, Duplantier-Duchêne, Cécile, Milhem, Antoine, Bertrand, Julien, Boursier, Michel, Khalife, Khalifé, Zannad, Noura, Zanutto, Aude, Cuvelier, Estelle, Donfafk, Cécile, Graux, Pierre, Guiot, Aurélie, Guyomar, Yves, Heuls, Sébastien, Kallumannil, John, Semichon, Marc, Gal, Benjamin, Lopez, Michel, Pineau, Julien, Dreyfus, Xavier, Hammer, Laure, Petit, Luc, Harle, Xavier, Laborderie, Julien, Albenque, Jean-Paul, Boveda, Serge, Combes, Nicolas, Combes, Stéphane, Goutner, Christophe, Césari, Olivier, Chenevez, Patrick, Loose, Christophe, Peycher, Patrick, Durand, Cyril, Durand-Dubief, Alexis, Poty, Hervé, Alonso, Christine, Cazeau, Serge, Grimard, Caroline, Jauvert, Gael, and Lazarus, Arnaud

Published
2015
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42. Impact of the COVID-19 pandemic on exercise habits among cancer patients

Author

Himbert, Caroline, primary, Hathaway, Cassandra A., additional, Daniels, Bailee, additional, Salas, Karen, additional, Ashworth, Anjelica, additional, Gigic, Biljana, additional, Lin, Tengda, additional, Viskochil, Richard, additional, Kirchhoff, Anne C., additional, Grossman, Douglas, additional, Ose, Jennifer, additional, Tward, Jonathan, additional, Scaife, Courtney, additional, Figueiredo, Jane C., additional, Toriola, Adetunji T., additional, Beck, Anna, additional, Shibata, David, additional, Gonzalez, Brian D., additional, Matsen, Cindy, additional, Christenson, Cristina, additional, Ma, Debra S., additional, Colman, Howard, additional, Hunt, Jason P., additional, Jones, Kevin B., additional, Lee, Catherine J., additional, Larson, Mikaela, additional, Onega, Tracy, additional, Akerley, Wallace L., additional, Li, Christopher I., additional, Schneider, Martin, additional, Penedo, Frank J., additional, Siegel, Erin M., additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, and Peoples, Anita R., additional

Published
2021
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44. Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients

Author

Stewart, Kelly L., primary, Gigic, Biljana, additional, Himbert, Caroline, additional, Warby, Christy A., additional, Ose, Jennifer, additional, Lin, Tengda, additional, Schrotz-King, Petra, additional, Boehm, Jürgen, additional, Jordan, Kristine C., additional, Metos, Julie, additional, Schneider, Martin, additional, Figueiredo, Jane C., additional, Li, Christopher I., additional, Shibata, David, additional, Siegel, Erin, additional, Toriola, Adetunji T., additional, Hardikar, Sheetal, additional, and Ulrich, Cornelia M., additional

Published
2021
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45. Multi-omics Analysis Reveals Adipose–tumor Crosstalk in Patients with Colorectal Cancer

Author

Holowatyj, Andreana N., primary, Haffa, Mariam, additional, Lin, Tengda, additional, Scherer, Dominique, additional, Gigic, Biljana, additional, Ose, Jennifer, additional, Warby, Christy A., additional, Himbert, Caroline, additional, Abbenhardt-Martin, Clare, additional, Achaintre, David, additional, Boehm, Juergen, additional, Boucher, Kenneth M., additional, Gicquiau, Audrey, additional, Gsur, Andrea, additional, Habermann, Nina, additional, Herpel, Esther, additional, Kauczor, Hans-Ulrich, additional, Keski-Rahkonen, Pekka, additional, Kloor, Matthias, additional, von Knebel-Doeberitz, Magnus, additional, Kok, Dieuwertje E., additional, Nattenmüller, Johanna, additional, Schirmacher, Peter, additional, Schneider, Martin, additional, Schrotz-King, Petra, additional, Simon, Thomas, additional, Ueland, Per M., additional, Viskochil, Richard, additional, Weijenberg, Matty P., additional, Scalbert, Augustin, additional, Ulrich, Alexis, additional, Bowers, Laura W., additional, Hursting, Stephen D., additional, and Ulrich, Cornelia M., additional

Published
2020
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46. Abstract 2364: Clinical characteristics and outcomes of colorectal cancer in the ColoCare Study: Differences by age of onset

Author

Himbert, Caroline, primary, Figueiredo, Jane, additional, Huang, Lyen, additional, Gigic, Biljana, additional, Scaife, Courtney L., additional, Pickron, Bartley, additional, Lambert, Laura, additional, Cohan, Jessica, additional, Bronner, Mary, additional, Jedrzkiewicz, Jolanta, additional, Herpel, Esther, additional, Kloor, Matthias, additional, Nattenmueller, Johanna, additional, Kauczor, Hans-Ulrich, additional, Ulrich, Alexis, additional, Felder, Seth, additional, Sanchez, Julian, additional, Dessureault, Sophie, additional, Hinkle, Nathan, additional, Monroe, Justin, additional, Mutch, Matthew, additional, Bernadt, Cory, additional, Chatterjee, Deyali, additional, Sinanan, Mika, additional, Cohen, Stacey, additional, Wallin, Ulrik, additional, Reddi, Deepti, additional, Krane, Mukta, additional, Gabayan, Afshin E., additional, Hoffman, David M., additional, Nasseri, Yosef Y., additional, Decker, Robert W., additional, Zaghiyan, Karen, additional, Murrell, Zuri A., additional, Hendifar, Andrew E., additional, Gong, Jun, additional, Firoozmand, Eiman, additional, Gangi, Alexandra, additional, Moore, Beth A., additional, Cologne, Kyle G., additional, El-Masry, Maryliza, additional, Grady, William, additional, Schneider, Martin, additional, Schmit, Stephanie L., additional, Siegel, Erin, additional, Shibata, David, additional, Toriola, Adetunji, additional, Li, Christopher, additional, Ulrich, Cornelia, additional, and Hardikar, Sheetal, additional

Published
2020
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47. Abstract 5745: Physical activity is associated with lymphocytic reaction to colorectal cancer: A pilot study

Author

Holowatyj, Andreana N., primary, Viskochil, Richard, additional, Himbert, Caroline, additional, Lin, Tengda, additional, Ose, Jennifer, additional, Peoples, Anita R., additional, Huang, Lyen C., additional, Pickron, Bartley, additional, Scaife, Courtney, additional, Boehm, Juergen, additional, Hardikar, Sheetal, additional, Bronner, Mary, additional, Figueiredo, Jane C., additional, Li, Christopher, additional, Schneider, Martin, additional, Shibata, David, additional, Siegel, Erin, additional, Toriola, Adetunji T., additional, Pletneva, Maria, additional, Swanson, Eric A., additional, and Ulrich, Cornelia M., additional

Published
2020
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49. Association of Sugar Intake with Inflammation- and Angiogenesis-Related Biomarkers in Newly Diagnosed Colorectal Cancer Patients.

Author

Stewart, Kelly L., Gigic, Biljana, Himbert, Caroline, Warby, Christy A., Ose, Jennifer, Lin, Tengda, Schrotz-King, Petra, Boehm, Jürgen, Jordan, Kristine C., Metos, Julie, Schneider, Martin, Figueiredo, Jane C., Li, Christopher I., Shibata, David, Siegel, Erin, Toriola, Adetunji T., Hardikar, Sheetal, and Ulrich, Cornelia M.

Subjects
OBESITY complications, INTERLEUKINS, C-reactive protein, INFLAMMATION, ACUTE phase proteins, MULTIPLE regression analysis, DIETARY sucrose, COLORECTAL cancer, CANCER patients, TUMOR classification, PEARSON correlation (Statistics), PATHOLOGIC neovascularization, TUMOR necrosis factors, DESCRIPTIVE statistics, QUESTIONNAIRES, TUMOR markers, INFLAMMATORY mediators, VASCULAR endothelial growth factors, ANTIGENS, DISEASE complications
Abstract

Evidence suggests a positive association between sugar intake and colorectal cancer (CRC) outcomes. We sought to investigate inflammation and angiogenesis as underlying mechanisms behind increased sugar intake and worse CRC outcomes. Pre-surgery serum samples were obtained from 191 patients diagnosed with primary invasive stage I-IV CRC. Biomarkers of inflammation (CRP, SAA, IL-6, IL-8, MCP-1, TNFα) and angiogenesis (VEGFA, VEGFD, sICAM-1 and sVCAM-1) were analyzed (Meso-Scale-Discovery). Fructose, glucose, sucrose, and total sugar intake (calories/day, % total calories) were assessed by FFQ. Pearson's correlation and multiple linear regression analyses were performed. Patients were on average 64 years old, 64% were male, the majority was diagnosed with stage II-III (58%) cancers, and 67% were either overweight or obese. Among normal-weight individuals (BMI <25 kg/m2), we observed a significant inverse association between VEGFD and any type of sugar intake in cal/day (sucrose: p = 0.01, glucose and fructose: p < 0.001) and MCP-1 and fructose intake (p = 0.05). The magnitude of reduction in VEGF ranged between −1.24 for sucrose to 4.49 for glucose intake, and −2.64 for fructose intake for MCP-1 levels. Sugar intake was associated with some inflammation or angiogenesis biomarkers, among CRC patients; differences were observed by adiposity that warrant further investigation. Supplemental data for this article is available online at at 10.1080/01635581.2021.1957133. [ABSTRACT FROM AUTHOR]

Published
2022
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50. One-carbon metabolites, B vitamins and associations with systemic inflammation and angiogenesis biomarkers among colorectal cancer patients: results from the ColoCare Study

Author

Kiblawi, Rama, Kiblawi, Rama, Holowatyj, Andreana N., Gigic, Biljana, Brezina, Stefanie, Geijsen, Anne J. M. R., Ose, Jennifer, Lin, Tengda, Hardikar, Sheetal, Himbert, Caroline, Warby, Christy A., Boehm, Juergen, Bourse, Martijn J. L., van Duijnhoven, Fraenzel J. B., Gumpenberger, Tanja, Kok, Dieuwertje E., Koole, Janna L., van Roekel, Eline H., Schrotz-King, Petra, Ulvikl, Arve, Gsur, Andrea, Habermann, Nina, Weijenberg, Matty P., Ueland, Per Magne, Schneiders, Martin, Ulrich, Alexis, Ulrich, Cornelia M., Playdon, Mary, Kiblawi, Rama, Kiblawi, Rama, Holowatyj, Andreana N., Gigic, Biljana, Brezina, Stefanie, Geijsen, Anne J. M. R., Ose, Jennifer, Lin, Tengda, Hardikar, Sheetal, Himbert, Caroline, Warby, Christy A., Boehm, Juergen, Bourse, Martijn J. L., van Duijnhoven, Fraenzel J. B., Gumpenberger, Tanja, Kok, Dieuwertje E., Koole, Janna L., van Roekel, Eline H., Schrotz-King, Petra, Ulvikl, Arve, Gsur, Andrea, Habermann, Nina, Weijenberg, Matty P., Ueland, Per Magne, Schneiders, Martin, Ulrich, Alexis, Ulrich, Cornelia M., and Playdon, Mary

Abstract

B vitamins involved in one-carbon metabolism have been implicated in the development of inflammation- and angiogenesis-related chronic diseases, such as colorectal cancer (CRC). Yet, the role of one-carbon metabolism in inflammation and angiogenesis among CRC patients remains unclear. The objective of this study was to investigate associations of components of one-carbon metabolism with inflammation and angiogenesis biomarkers among newly diagnosed CRC patients (n 238) in the prospective ColoCare Study, Heidelberg. We cross-sectionally analysed associations between twelve B vitamins and one-carbon metabolites and ten inflammation and angiogenesis biomarkers from pre-surgery serum samples using multivariable linear regression models. We further explored associations among novel biomarkers in these pathways with Spearman partial correlation analyses. We hypothesised that pyridoxal-5'-phosphate (PLP) is inversely associated with inflammatory biomarkers. We observed that PLP was inversely associated with C-reactive protein (CRP) (r -0 center dot 33, P-linear <0 center dot 0001), serum amyloid A (SAA) (r -0 center dot 23, P-linear = 0 center dot 003), IL-6 (r -0 center dot 39, P-linear <0 center dot 0001), IL-8 (r -0 center dot 20, P-linear = 0 center dot 02) and TNF alpha (r -0 center dot 12, P-linear = 0 center dot 045). Similar findings were observed for 5-methyl-tetrahydrofolate and CRP (r -0 center dot 14), SAA (r -0 center dot 14) and TNF alpha (r -0 center dot 15) among CRC patients. Folate catabolite acetyl-para-aminobenzoylglutamic acid (pABG) was positively correlated with IL-6 (r 0 center dot 27, P-linear <0 center dot 0001), and pABG was positively correlated with IL-8 (r 0 center dot 21, P-linear <0 center dot 0001), indicating higher folate utilisation during inflammation. Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among CRC patients. A better understanding of the role and inter-relation of

Published
2020

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