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29 results on '"Hinkle, Kelly M"'

1. Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease

Author

Kouri, Naomi, primary, Frankenhauser, Isabelle, additional, Peng, Zhongwei, additional, Labuzan, Sydney A., additional, Boon, Baayla D. C., additional, Moloney, Christina M., additional, Pottier, Cyril, additional, Wickland, Daniel P., additional, Caetano-Anolles, Kelsey, additional, Corriveau-Lecavalier, Nick, additional, Tranovich, Jessica F., additional, Wood, Ashley C., additional, Hinkle, Kelly M., additional, Lincoln, Sarah J., additional, Spychalla, A. J., additional, Senjem, Matthew L., additional, Przybelski, Scott A., additional, Engelberg-Cook, Erica, additional, Schwarz, Christopher G., additional, Kwan, Rain S., additional, Lesser, Elizabeth R., additional, Crook, Julia E., additional, Carter, Rickey E., additional, Ross, Owen A., additional, Lachner, Christian, additional, Ertekin-Taner, Nilüfer, additional, Ferman, Tanis J., additional, Fields, Julie A., additional, Machulda, Mary M., additional, Ramanan, Vijay K., additional, Nguyen, Aivi T., additional, Reichard, R. Ross, additional, Jones, David T., additional, Graff-Radford, Jonathan, additional, Boeve, Bradley F., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, Kantarci, Kejal, additional, Day, Gregory S., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Lowe, Val J., additional, Vemuri, Prashanthi, additional, and Murray, Melissa E., additional

Published
2024
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3. Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease

Author

Crist, Angela M., Hinkle, Kelly M., Wang, Xue, Moloney, Christina M., Matchett, Billie J., Labuzan, Sydney A., Frankenhauser, Isabelle, Azu, Nkem O., Liesinger, Amanda M., Lesser, Elizabeth R., Serie, Daniel J., Quicksall, Zachary S., Patel, Tulsi A., Carnwath, Troy P., DeTure, Michael, Tang, Xiaojia, Petersen, Ronald C., Duara, Ranjan, Graff-Radford, Neill R., Allen, Mariet, Carrasquillo, Minerva M., Li, Hu, Ross, Owen A., Ertekin-Taner, Nilüfer, Dickson, Dennis W., Asmann, Yan W., Carter, Rickey E., and Murray, Melissa E.

Published
2021
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4. Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort

Author

Santos, Octavio A., Pedraza, Otto, Lucas, John A., Duara, Ranjan, Greig-Custo, Maria T., Hanna Al-Shaikh, Fadi S., Liesinger, Amanda M., Bieniek, Kevin F., Hinkle, Kelly M., Lesser, Elizabeth R., Crook, Julia E., Carrasquillo, Minerva M., Ross, Owen A., Ertekin-Taner, Nilüfer, Graff-Radford, Neill R., Dickson, Dennis W., and Murray, Melissa E.

Published
2019
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5. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Author

Hinkle, Kelly M, Yue, Mei, Behrouz, Bahareh, Dächsel, Justus C, Lincoln, Sarah J, Bowles, Erin E, Beevers, Joel E, Dugger, Brittany, Winner, Beate, Prots, Iryna, Kent, Caroline B, Nishioka, Kenya, Lin, Wen-Lang, Dickson, Dennis W, Janus, Christopher J, Farrer, Matthew J, and Melrose, Heather L

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Neurosciences, Biological Sciences, Brain Disorders, Parkinson's Disease, Behavioral and Social Science, Aging, Neurodegenerative, Genetics, Aetiology, 2.1 Biological and endogenous factors, Neurological, Animals, Autophagy, Behavior, Animal, Dopamine, Kidney, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Neurons, Parkinson Disease, Protein Serine-Threonine Kinases, Parkinson's disease, Knockout, Microdialysis, Neuropathology, Open-field, Motor coordination, Protein-Serine-Threonine Kinases, Clinical Sciences, Neurology & Neurosurgery, Biochemistry and cell biology
Abstract

Mutations in the LRRK2 gene are the most common cause of genetic Parkinson's disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2. We have performed a comprehensive analysis of these mice up to 20 months of age, including evaluation of dopamine storage, release, uptake and synthesis, behavioral testing, dendritic spine and proliferation/neurogenesis analysis.Our results show that the dopaminergic system was not functionally comprised in LRRK2 knockout mice. However, LRRK2 knockout mice displayed abnormal exploratory activity in the open-field test. Moreover, LRRK2 knockout mice stayed longer than their wild type littermates on the accelerated rod during rotarod testing. Finally, we confirm that loss of LRRK2 caused degeneration in the kidney, accompanied by a progressive enhancement of autophagic activity and accumulation of autofluorescent material, but without evidence of biphasic changes.

Published
2012

6. Retrospective Evaluation of Neuropathologic Proxies of the Minimal Atrophy Subtype Compared With Corticolimbic Alzheimer Disease Subtypes

Author

Boon, Baayla D.C., primary, Labuzan, Sydney A., additional, Peng, Zhongwei, additional, Matchett, Billie J., additional, Kouri, Naomi, additional, Hinkle, Kelly M., additional, Lachner, Christian, additional, Ross, Owen A., additional, Ertekin-Taner, Nilufer, additional, Carter, Rickey E., additional, Ferman, Tanis J., additional, Duara, Ranjan, additional, Dickson, Dennis W., additional, Graff-Radford, Neill R., additional, and Murray, Melissa E., additional

Published
2023
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9. Clinicoradiologic Correlates of Corticolimbic Index (CLix) and Glial Activation Differences Among Neuropathologic Subtypes of Alzheimer's Disease: A Retrospective Study

Author

Kouri, Naomi, primary, Frankenhauser, Isabelle, additional, Peng, Zhongwei, additional, Labuzan, Sydney A., additional, Boon, Baayla D.C., additional, Moloney, Christina M., additional, Pottier, Cyril, additional, Wickland, Daniel P., additional, Caetano-Anolles, Kelsey, additional, Corriveau-Lecavalier, Nick, additional, Tranovich, Jessica F., additional, Wood, Ashley C., additional, Hinkle, Kelly M., additional, Lincoln, Sarah J., additional, Spychalla, Anthony J., additional, Senjem, Matthew L., additional, Przybelski, Scott A., additional, Engelberg-Cook, Erica, additional, Schwarz, Christopher G., additional, Kwan, Rain S., additional, Lesser, Elizabeth R., additional, Crook, Julia E., additional, Carter, Rickey, additional, Ross, Owen A., additional, Lachner, Christian, additional, Ertekin-Taner, Nilüfer, additional, Ferman, Tanis J., additional, Machulda, Mary M., additional, Ramanan, Vijay K., additional, Nguyen, Aivi T., additional, Reichard, R. Ross, additional, Jones, David T., additional, Graff-Radford, Jonathan, additional, Boeve, Bradley F., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Jack Jr., Clifford R., additional, Kantarci, Kejal, additional, Day, Gregory S., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Lowe, Val J., additional, Vemuri, Prashanthi, additional, and Murray, Melissa E., additional

Published
2023
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10. Digital Pathology Investigation of SERPINA5‐Tau Protein Interaction in Alzheimer’s Disease and Primary Tauopathies

Author

Sirmans, Tiffany N. Hicks, primary, Kouri, Naomi, additional, Tamvaka, Nicole, additional, Labuzan, Sydney A, additional, Matchett, Billie J, additional, Lincoln, Sarah J., additional, Hinkle, Kelly M, additional, Moloney, Christina M., additional, Peng, Zhongwei, additional, Carter, Rickey E, additional, Ross, Owen A., additional, Ertekin‐Taner, Nilufer, additional, Duara, Ranjan, additional, Graff‐Radford, Neill R., additional, Dickson, Dennis W., additional, and Murray, Melissa E., additional

Published
2022
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13. A novel tau mutation, p.K317N, causes globular glial tauopathy

Author

Tacik, Pawel, DeTure, Michael, Lin, Wen-Lang, Sanchez Contreras, Monica, Wojtas, Aleksandra, Hinkle, Kelly M., Fujioka, Shinsuke, Baker, Matthew C., Walton, Ronald L., Carlomagno, Yari, Brown, Patricia H., Strongosky, Audrey J., Kouri, Naomi, Murray, Melissa E., Petrucelli, Leonard, Josephs, Keith A., Rademakers, Rosa, Ross, Owen A., Wszolek, Zbigniew K., and Dickson, Dennis W.

Published
2015
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16. Genetic analyses of SERPINA5 in Alzheimer’s disease

Author

Matchett, Billie J., primary, Lincoln, Sarah J., additional, Baker, Matt, additional, Tamvaka, Nikoleta, additional, Cabrera-Rodriguez, Janisse, additional, Labuzan, Sydney A., additional, Helminger, Jacqueline, additional, Hinkle, Kelly M., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Ertekin-Taner, Nilüfer, additional, Ross, Owen A., additional, Rademakers, Rosa, additional, Dickson, Dennis W., additional, and Murray, Melissa, additional

Published
2021
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20. Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5

Author

Crist, Angela M., primary, Hinkle, Kelly M., additional, Wang, Xue, additional, Moloney, Christina M., additional, Matchett, Billie J., additional, Labuzan, Sydney A., additional, Frankenhauser, Isabelle, additional, Azu, Nkem O., additional, Liesinger, Amanda M., additional, Lesser, Elizabeth R., additional, Serie, Daniel J., additional, Quicksall, Zachary S., additional, Patel, Tulsi A., additional, Carnwath, Troy P., additional, DeTure, Michael, additional, Tang, Xiaojia, additional, Petersen, Ronald C., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Allen, Mariet, additional, Carrasquillo, Minerva M., additional, Li, Hu, additional, Ross, Owen A., additional, Ertekin-Taner, Nilufer, additional, Dickson, Dennis W., additional, Asmann, Yan W., additional, Carter, Rickey E., additional, and Murray, Melissa E., additional

Published
2020
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21. Investigating gene expression changes underlying selective hippocampal vulnerability in Alzheimer’s disease using a translational neuropathology approach

Author

Crist, Angela M., primary, Hinkle, Kelly M., additional, Wang, Xue, additional, Lesser, Elizabeth R., additional, Azu, Nkem O., additional, Moloney, Christina M., additional, Frankenhauser, Isabelle, additional, Labuzan, Sydney A., additional, Matchett, Billie J., additional, Liesinger, Amanda M., additional, Serie, Daniel, additional, DeTure, Michael, additional, Cook, Casey, additional, Petrucelli, Leonard, additional, Petersen, Ronald C., additional, Duara, Ranjan, additional, Graff‐Radford, Neill R., additional, Allen, Mariet, additional, Carrasquillo, Minerva M., additional, Li, Hu, additional, Ross, Owen A., additional, Ertekin‐Taner, Nilufer, additional, Dickson, Dennis W., additional, Asmann, Yan W., additional, Carter, Rickey E, additional, and Murray, Melissa E, additional

Published
2020
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22. Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

Author

Hanna Al-Shaikh, Fadi S., primary, Duara, Ranjan, additional, Crook, Julia E., additional, Lesser, Elizabeth R., additional, Schaeverbeke, Jolien, additional, Hinkle, Kelly M., additional, Ross, Owen A., additional, Ertekin-Taner, Nilufer, additional, Pedraza, Otto, additional, Dickson, Dennis W., additional, Graff-Radford, Neill R., additional, and Murray, Melissa E., additional

Published
2020
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24. The SERPINA5 coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer's disease: A cross-sectional study.

Author

Matchett, Billie J., Lincoln, Sarah J., Baker, Matt, Tamvaka, Nikoleta, Labuzan, Sydney A., Hicks Sirmans, Tiffany N., Moloney, Christina M., Helminger, Jacqueline, Hinkle, Kelly M., Cabrera-Rodriguez, Janisse, Wickland, Daniel P., Johnson, Patrick W., Heckman, Michael G., Reddy, Joseph S., Younkin, Steven G., Carrasquillo, Minerva M., Duara, Ranjan, Graff-Radford, Neill R., Pottier, Cyril, and Ertekin-Taner, Nilüfer

Published
2023
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26. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Author

Davies, Paul, primary, Hinkle, Kelly M., additional, Sukar, Nour N., additional, Sepulveda, Bryan, additional, Mesias, Roxana, additional, Serrano, Geidy, additional, Alessi, Dario R., additional, Beach, Thomas G., additional, Benson, Deanna L., additional, White, Charles L., additional, Cowell, Rita M., additional, Das, Sonal S., additional, West, Andrew B., additional, and Melrose, Heather L., additional

Published
2013
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27. The SERPINA5coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer’s disease: A cross-sectional study

Author

Matchett, Billie J., Lincoln, Sarah J., Baker, Matt, Tamvaka, Nikoleta, Labuzan, Sydney A., Hicks Sirmans, Tiffany N., Moloney, Christina M., Helminger, Jacqueline, Hinkle, Kelly M., Cabrera-Rodriguez, Janisse, Wickland, Daniel P., Johnson, Patrick W., Heckman, Michael G., Reddy, Joseph S., Younkin, Steven G., Carrasquillo, Minerva M., Duara, Ranjan, Graff-Radford, Neill R., Pottier, Cyril, Ertekin-Taner, Nilüfer, Ross, Owen A., Rademakers, Rosa, Dickson, Dennis W., and Murray, Melissa E.

Abstract

We previously demonstrated that increased expression of the SERPINA5gene is associated with hippocampal vulnerability in Alzheimer’s disease (AD) brains. SERPINA5was further demonstrated to be a novel tau-binding partner that colocalizes within neurofibrillary tangles. Our goal was to determine whether genetic variants in the SERPINA5gene contributed to clinicopathologic phenotypes in AD. To screen for SERPINA5variants, we sequenced 103 autopsy-confirmed young-onset AD cases with a positive family history of cognitive decline. To further assess the frequency of a rare missense variant, SERPINA5p.E228Q, we screened an additional 1114 neuropathologically diagnosed AD cases. To provide neuropathologic context in AD, we immunohistochemically evaluated SERPINA5and tau in a SERPINA5p.E228Q variant carrier and a matched noncarrier. In the initial SERPINA5screen, we observed 1 individual with a rare missense variant (rs140138746) that resulted in an amino acid change (p.E228Q). In our AD validation cohort, we identified an additional 5 carriers of this variant, resulting in an allelic frequency of 0.0021. There was no significant difference between SERPINA5p.E228Q carriers and noncarriers in terms of demographic or clinicopathologic characteristics. Although not significant, on average SERPINA5p.E228Q carriers were 5 years younger at age of disease onset than noncarriers (median: 66 [60–73] vs 71 [63–77] years, P= .351). In addition, SERPINA5p.E228Q carriers exhibited a longer disease duration than noncarriers that approached significance (median: 12 [10–15]) vs 9 [6–12] years, P= .079). More severe neuronal loss was observed in the locus coeruleus, hippocampus, and amygdala of the SERPINA5p.E228Q carrier compared to noncarrier, although no significant difference in SERPINA5-immunopositive lesions was observed. Throughout the AD brain in either carrier or noncarrier, areas with early pretangle pathology or burnt-out ghost tangle accumulation did not reveal SERPINA5-immunopositive neurons. Mature tangles and newly formed ghost tangles appeared to correspond well with SERPINA5-immunopositive tangle-bearing neurons. SERPINA5gene expression was previously associated with disease phenotype; however, our findings suggest that SERPINA5genetic variants may not be a contributing factor to clinicopathologic differences in AD. SERPINA5-immunopositive neurons appear to undergo a pathologic process that corresponded with specific levels of tangle maturity.

Published
2023
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29. Pick's Disease with Clinical Manifestation of Corticobasal Syndrome

Author

Tacik, Pawel, Contreras, Monica Sanchez, Wojtas, Aleksandra, Perkerson, Ralph B., Baker, Matthew C., Brown, Patricia, Strongosky, Audrey J., Hinkle, Kelly M., Fujioka, Shinsuke, Takuya Konno, Deture, Michael, Kouri, Naomi, Murray, Melissa E., Graff-Radford, Neill R., Rademakers, Rosa, Ross, Owen A., Wszolek, Zbigniew K., and Dickson, Dennis W.

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