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1. CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses

Author

Bawden, Emma G., primary, Wagner, Teagan, additional, Schröder, Jan, additional, Effern, Maike, additional, Hinze, Daniel, additional, Newland, Lewis, additional, Attrill, Grace H., additional, Lee, Ariane R., additional, Engel, Sven, additional, Freestone, David, additional, de Lima Moreira, Marcela, additional, Gressier, Elise, additional, McBain, Nathan, additional, Bachem, Annabell, additional, Haque, Ashraful, additional, Dong, Ruining, additional, Ferguson, Angela L., additional, Edwards, Jarem J., additional, Ferguson, Peter M., additional, Scolyer, Richard A., additional, Wilmott, James S., additional, Jewell, Christopher M., additional, Brooks, Andrew G., additional, Gyorki, David E., additional, Palendira, Umaimainthan, additional, Bedoui, Sammy, additional, Waithman, Jason, additional, Hochheiser, Katharina, additional, Hölzel, Michael, additional, and Gebhardt, Thomas, additional

Published
2024
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2. CD4+ T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses.

Author

Bawden, Emma G., Wagner, Teagan, Schröder, Jan, Effern, Maike, Hinze, Daniel, Newland, Lewis, Attrill, Grace H., Lee, Ariane R., Engel, Sven, Freestone, David, de Lima Moreira, Marcela, Gressier, Elise, McBain, Nathan, Bachem, Annabell, Haque, Ashraful, Dong, Ruining, Ferguson, Angela L., Edwards, Jarem J., Ferguson, Peter M., and Scolyer, Richard A.

Subjects
T cells, CYTOTOXIC T cells, NITRIC-oxide synthases, MYELOID cells, MAJOR histocompatibility complex, HUMORAL immunity, GRAFT versus host reaction
Abstract

Whereas CD4+ T cells conventionally mediate antitumor immunity by providing help to CD8+ T cells, recent clinical studies have implied an important role for cytotoxic CD4+ T cells in cancer immunity. Using an orthotopic melanoma model, we provide a detailed account of antitumoral CD4+ T cell responses and their regulation by major histocompatibility complex class II (MHC II) in the skin. Intravital imaging revealed prominent interactions of CD4+ T cells with tumor debris-laden MHC II+ host antigen-presenting cells that accumulated around tumor cell nests, although direct recognition of MHC II+ melanoma cells alone could also promote CD4+ T cell control. CD4+ T cells stably suppressed or eradicated tumors even in the absence of other lymphocytes by using tumor necrosis factor–α and Fas ligand (FasL) but not perforin-mediated cytotoxicity. Interferon-γ was critical for protection, acting both directly on melanoma cells and via induction of nitric oxide synthase in myeloid cells. Our results illustrate multifaceted and context-specific aspects of MHC II–dependent CD4+ T cell immunity against cutaneous melanoma, emphasizing modulation of this axis as a potential avenue for immunotherapies. Editor's summary: CD4+ T cells have been primarily appreciated for their helper functions in antitumor immune responses, but the extent to which they directly contribute to tumor killing remains unclear. Using a mouse model of cutaneous melanoma, Bawden et al. characterized the effector functions of CD4+ T cells in generating protective antitumor immunity. Melanoma-specific CD4+ T cells infiltrated tumors, adopted diverse effector states, and could provide tumor protection independent of other lymphocytes. Whereas MHC II expression by melanoma cells was sufficient to activate protective CD4+ T cell–mediated immunity, host antigen-presenting cells could also drive protection. CD4+ T cells provided protection through multiple partially redundant cytotoxicity pathways, including TNF and Fas ligand, but also by activating IFN-γ–dependent nitric oxide production in myeloid cells. Together, these results demonstrate that tumor-infiltrating CD4+ T cells are equipped to contribute to tumor control through multiple helper and effector modes. —Claire Olingy [ABSTRACT FROM AUTHOR]

Published
2024
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3. Nick Potts and Andrew Kliman: Is Marx's Theory of Profit Right? The Simultaneish-Temporalist Debate

Author

Hinze, Daniel

Subjects
Is Marx's Theory of Profit Right? The Simultaneist-temporalist Debate (Nonfiction work) -- Potts, Nick -- Kliman, Andrew -- Book reviews, Economics
Abstract

Nick Potts and Andrew KlimanIs Marx's Theory of Profit Right? The SimultaneishTemporalist Debate, Lanham, MD: Lexington Books, 2015; 180 pp.: ISBN 978-0-7391-9631-1, 60 [pounds sterling] (hb)This book brings together scholarly [...]

Published
2018

4. Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Author

Karreman, Matthia A., primary, Bauer, Alexander T., primary, Solecki, Gergely, primary, Berghoff, Anna S., primary, Mayer, Chanté D., primary, Frey, Katharina, primary, Hebach, Nils, primary, Feinauer, Manuel J., primary, Schieber, Nicole L., primary, Tehranian, Cedric, primary, Mercier, Luc, primary, Singhal, Mahak, primary, Venkataramani, Varun, primary, Schubert, Marc C., primary, Hinze, Daniel, primary, Hölzel, Michael, primary, Helfrich, Iris, primary, Schadendorf, Dirk, primary, Schneider, Stefan W., primary, Westphal, Dana, primary, Augustin, Hellmut G., primary, Goetz, Jacky G., primary, Schwab, Yannick, primary, Wick, Wolfgang, primary, and Winkler, Frank, primary

Published
2023
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5. Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Author

Karreman, Matthia A., primary, Bauer, Alexander T., primary, Solecki, Gergely, primary, Berghoff, Anna S., primary, Mayer, Chanté D., primary, Frey, Katharina, primary, Hebach, Nils, primary, Feinauer, Manuel J., primary, Schieber, Nicole L., primary, Tehranian, Cedric, primary, Mercier, Luc, primary, Singhal, Mahak, primary, Venkataramani, Varun, primary, Schubert, Marc C., primary, Hinze, Daniel, primary, Hölzel, Michael, primary, Helfrich, Iris, primary, Schadendorf, Dirk, primary, Schneider, Stefan W., primary, Westphal, Dana, primary, Augustin, Hellmut G., primary, Goetz, Jacky G., primary, Schwab, Yannick, primary, Wick, Wolfgang, primary, and Winkler, Frank, primary

Published
2023
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6. Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

Author

Martins Nascentes Melo, Luiza, primary, Herrera-Rios, Dayana, additional, Hinze, Daniel, additional, Löffek, Stefanie, additional, Oezel, Irem, additional, Turiello, Roberta, additional, Klein, Juliane, additional, Leonardelli, Sonia, additional, Westedt, Isa-Vanessa, additional, Al-Matary, Yahya, additional, Egea-Rodriguez, Sara, additional, Brenzel, Alexandra, additional, Bau, Maja, additional, Sucker, Antje, additional, Hadaschik, Eva, additional, Wirsdörfer, Florian, additional, Hanenberg, Helmut, additional, Uhlenbrock, Niklas, additional, Rauh, Daniel, additional, Poźniak, Joanna, additional, Rambow, Florian, additional, Marine, Jean-Christophe, additional, Effern, Maike, additional, Glodde, Nicole, additional, Schadendorf, Dirk, additional, Jablonska, Jadwiga, additional, Hölzel, Michael, additional, and Helfrich, Iris, additional

Published
2023
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7. Samezo Kuruma: Marx's Theory of the Genesis of Money--How, Why, and Through What Is a Commodity Money?

Author

Hinze, Daniel

Subjects
Marx's Theory of the Genesis of Money: How, Why, and Through What Is a Commodity Money? (Nonfiction work) -- Kuruma, Samezo -- Book reviews, Books -- Book reviews, Economics
Abstract

Samezo Kuruma Marx's Theory of the Genesis of Money--How, Why, and Through What Is a Commodity Money? Leiden: Brill, 2017; 194 pp.: ISBN 9789004322387, 87 [pounds sterling] This is a [...]

Published
2019
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9. Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Author

Karreman, Matthia A., primary, Bauer, Alexander T., additional, Solecki, Gergely, additional, Berghoff, Anna S., additional, Mayer, Chanté D., additional, Frey, Katharina, additional, Hebach, Nils, additional, Feinauer, Manuel J., additional, Schieber, Nicole L., additional, Tehranian, Cedric, additional, Mercier, Luc, additional, Singhal, Mahak, additional, Venkataramani, Varun, additional, Schubert, Marc C., additional, Hinze, Daniel, additional, Hölzel, Michael, additional, Helfrich, Iris, additional, Schadendorf, Dirk, additional, Schneider, Stefan W., additional, Westphal, Dana, additional, Augustin, Hellmut G., additional, Goetz, Jacky G., additional, Schwab, Yannick, additional, Wick, Wolfgang, additional, and Winkler, Frank, additional

Published
2023
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11. Robert Kurz: The Substance of Capital

Author

Hinze, Daniel

Subjects
The Substance of Capital (Nonfiction work) -- Kurz, Robert -- Book reviews, Economics
Abstract

Robert Kurz The Substance of Capital, London: Chronos Publications, 2016; 230 pp.: ISBN 9780995609501, 9.99 [pounds sterling] The Substance of Capital is part of The Life and Death of Capitalism [...]

Published
2018
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12. Abstract 2487: Distinct venous brain vessels provide structures for T lymphocyte recruitment to brain tumors in mouse models of intracranial melanoma

Author

Messmer, Julia M., primary, Piechutta, Manuel, additional, Venkataramani, Varun, additional, Mayer, Chanté, additional, Berghoff, Anna S., additional, Hinze, Daniel, additional, Hölzel, Michael, additional, Helfrich, Iris, additional, Schadendorf, Dirk, additional, Wick, Wolfgang, additional, Karreman, Matthia A., additional, and Winkler, Frank, additional

Published
2022
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16. Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

Author

Glodde, Nicole, Bald, Tobias, van den Boorn-Konijnenberg, Debby, Nakamura, Kyohei, OʼDonnell, Jake S., Szczepanski, Sabrina, Brandes, Maria, Eickhoff, Sarah, Das, Indrajit, Shridhar, Naveen, Hinze, Daniel, Rogava, Meri, van der Sluis, Tetje C., Ruotsalainen, Janne J., Gaffal, Evelyn, Landsberg, Jennifer, Ludwig, Kerstin U., Wilhelm, Christoph, Riek-Burchardt, Monika, Müller, Andreas J., Gebhardt, Christoffer, Scolyer, Richard A., Long, Georgina V., Janzen, Viktor, Teng, Michele W.L., Kastenmüller, Wolfgang, Mazzone, Massimiliano, Smyth, Mark J., Tüting, Thomas, and Hölzel, Michael

Published
2017
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17. Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Author

Effern, Maike, Glodde, Nicole, Braun, Matthias, Liebing, Jana, Boll, Helena N., Yong, Michelle, Bawden, Emma, Hinze, Daniel, Van den Boorn-Konijnenberg, Debby, Daoud, Mila, Aymans, Pia, Landsberg, Jennifer, Smyth, Mark J., Flatz, Lukas, Tueting, Thomas, Bald, Tobias, Gebhardt, Thomas, Hoelzel, Michael, Effern, Maike, Glodde, Nicole, Braun, Matthias, Liebing, Jana, Boll, Helena N., Yong, Michelle, Bawden, Emma, Hinze, Daniel, Van den Boorn-Konijnenberg, Debby, Daoud, Mila, Aymans, Pia, Landsberg, Jennifer, Smyth, Mark J., Flatz, Lukas, Tueting, Thomas, Bald, Tobias, Gebhardt, Thomas, and Hoelzel, Michael

Abstract

Tumor immune escape limits durable responses to T cell therapy. Here, we examined how regulation and function of gene products that provide the target epitopes for CD8(+) T cell anti-tumor immunity influence therapeutic efficacy and resistance. We used a CRISPR-Cas9-based method (CRISPitope) in syngeneic melanoma models to fuse the same model CD8(+) T cell epitope to the C-termini of different endogenous gene products. Targeting melanosomal proteins or oncogenic CDK4(R24C )(Cyclin-dependent kinase 4) by adoptive cell transfer (ACT) of the same epitope-specific CD8(+) T cells revealed diverse genetic and non-genetic immune escape mechanisms. ACT directed against melanosomal proteins, but not CDK4(R24C), promoted melanoma dedifferentiation, and increased myeloid cell infiltration. CDK4(R24C) antigen persistence was associated with an interferon-high and T-cell-rich tumor microenvironment, allowing for immune checkpoint inhibition as salvage therapy. Thus, the choice of target antigen determines the phenotype and immune contexture of recurrent melanomas, with implications to the design of cancer immunotherapies.

Published
2020

20. Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Author

Effern, Maike, primary, Glodde, Nicole, additional, Braun, Matthias, additional, Liebing, Jana, additional, Boll, Helena N., additional, Yong, Michelle, additional, Bawden, Emma, additional, Hinze, Daniel, additional, van den Boorn-Konijnenberg, Debby, additional, Daoud, Mila, additional, Aymans, Pia, additional, Landsberg, Jennifer, additional, Smyth, Mark J., additional, Flatz, Lukas, additional, Tüting, Thomas, additional, Bald, Tobias, additional, Gebhardt, Thomas, additional, and Hölzel, Michael, additional

Published
2020
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23. A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation

Author

Jobin, Katarzyna, primary, Stumpf, Natascha E., additional, Schwab, Sebastian, additional, Eichler, Melanie, additional, Neubert, Patrick, additional, Rauh, Manfred, additional, Adamowski, Marek, additional, Babyak, Olena, additional, Hinze, Daniel, additional, Sivalingam, Sugirthan, additional, Weisheit, Christina, additional, Hochheiser, Katharina, additional, Schmidt, Susanne V., additional, Meissner, Mirjam, additional, Garbi, Natalio, additional, Abdullah, Zeinab, additional, Wenzel, Ulrich, additional, Hölzel, Michael, additional, Jantsch, Jonathan, additional, and Kurts, Christian, additional

Published
2020
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31. Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

Author

Layer, Julian P., Kronmueller, Marie T., Quast, Thomas, van den Boorn-Konijnenberg, Debby, Effern, Maike, Hinze, Daniel, Althoff, Kristina, Schramm, Alexander, Westermann, Frank, Peifer, Martin, Hartmann, Gunther, Tueting, Thomas, Kolanus, Waldemar, Fischer, Matthias, Schulte, Johannes, Hoelzel, Michael, Layer, Julian P., Kronmueller, Marie T., Quast, Thomas, van den Boorn-Konijnenberg, Debby, Effern, Maike, Hinze, Daniel, Althoff, Kristina, Schramm, Alexander, Westermann, Frank, Peifer, Martin, Hartmann, Gunther, Tueting, Thomas, Kolanus, Waldemar, Fischer, Matthias, Schulte, Johannes, and Hoelzel, Michael

Abstract

Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load. Accordingly, checkpoint immunotherapy is thought to be less effective in tumors with low mutation frequencies such as neuroblastoma, a neuroendocrine tumor of early childhood with poor outcome of the high-risk disease group. However, spontaneous regressions and paraneoplastic syndromes seen in neuroblastoma patients suggest substantial immunogenicity. Using an integrative transcriptomic approach, we investigated the molecular characteristics of T-cell infiltration in primary neuroblastomas as an indicator of pre-existing immune responses and potential responsiveness to checkpoint inhibition. Here, we report that a T-cell-poor microenvironment in primary metastatic neuroblastomas is associated with genomic amplification of the MYCN (N-Myc) proto-oncogene. These tumors exhibited lower interferon pathway activity and chemokine expression in line with reduced immune cell infiltration. Importantly, we identified a global role for N-Myc in the suppression of interferon and pro-inflammatory pathways in human and murine neuroblastoma cell lines. N-Myc depletion potently enhanced targeted interferon pathway activation by a small molecule agonist of the cGAS-STING innate immune pathway. This promoted chemokine expression including Cxcl10 and T-cell recruitment in microfluidics migration assays. Hence, our data suggest N-Myc inhibition plus targeted IFN activation as adjuvant strategy to enforce cytotoxic T-cell recruitment in MYCN-amplified neuroblastomas.

Published
2017

32. Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

Author

Layer, Julian P., primary, Kronmüller, Marie T., additional, Quast, Thomas, additional, Boorn-Konijnenberg, Debby van den, additional, Effern, Maike, additional, Hinze, Daniel, additional, Althoff, Kristina, additional, Schramm, Alexander, additional, Westermann, Frank, additional, Peifer, Martin, additional, Hartmann, Gunther, additional, Tüting, Thomas, additional, Kolanus, Waldemar, additional, Fischer, Matthias, additional, Schulte, Johannes, additional, and Hölzel, Michael, additional

Published
2017
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33. Re-designing a more circular Scottish economy

Author

Mearns, Ewan and Hinze, Daniel

Subjects
HB
Abstract

Policies to develop a more circular economy can unlock opportunities that change how businesses, supply chains and economies could operate in the 21st Century. Such approaches build on the application of earlier concepts of industrial ecology (Frosch and Gallopoulos, 1989), cradle-to-cradle (Braungart and MacDonough, 2002) and the performance economy (Stahel, 2010). This article explores the nature, benefits, barriers and enablers of the shift towards a more circular Scottish economy, drawing on the global evidence and the programme of research undertaken by the Scottish Government and its public sector partners. In particular, it assesses the nature and scale of the opportunities in two of Scotland’s growth sectors – oil & gas and the bioeconomy – and highlights the policy and evidence issues that will be important to support the transition to a more circular – and sustainable – Scottish economy.

Published
2015

34. Ordered Media in Chemical Separations

Author

WILLIE L. HINZE, DANIEL W. ARMSTRONG, Willie L. Hinze, Janos H. Fendler, John G. Dorsey, Frank G. P. Mullins, Alain Berthod, Ines Girard, Colette Gonnet, M. J. Sepaniak, D. E. Burton, M. P. Maskarinec, E. Pramauro, C. Minero, E. Pelizzetti, P. L. Dubin, T. D. Ross, I. Sharma, B. E. Yegerlehner, T. A

Published
1987

35. Book Review: Accounting for Value in Marx's Capital.

Author

Hinze, Daniel

Subjects
*MARXIAN economics, *ACCOUNT books, *BUSINESS success, *COST accounting, *FINANCIAL statements, *WORKING capital
Abstract

Accounting for Value in Marx's Capital Bryer, Rob. However, the correspondence between accounting practice and Marx's theory applies only when values are decreasing, as upward accounting adjustments - which Marx would admit - are ruled out by prudential accounting guidelines. [Extracted from the article]

Published
2021
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36. Book Review: The Routledge Handbook of Heterodox Economics.

Author

Hinze, Daniel

Subjects
*HETERODOX economics, *NEOCLASSICAL school of economics, *BUSINESS cycles, *BUSINESS enterprises, *ECONOMIC research
Abstract

Unfortunately, we are not told how the current drivers of accumulation would be overcome or why the "transformation" of capitalism has to result in capitalism. The author flies the flag for "state capitalism" as a new form of modern capitalism and brings Russia into the discussion, which fatally undermines the case. The problem with making "provisioning" the central question of economic analysis is that it takes a pre-analytical position that assigns an inherent purpose to the economy and skips over the analysis of capitalism on its own terms. [Extracted from the article]

Published
2020
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38. CRISPitope: A generic platform to model target antigens for adoptive T cell transfer therapy in mouse tumor models

Author

Effern, Maike, Glodde, Nicole, Bawden, Emma, Liebing, Jana, Hinze, Daniel, Tüting, Thomas, Gebhardt, Thomas, and Hölzel, Michael

Abstract

This protocol details the procedure for CRISPR-assisted insertion of epitopes (CRISPitope), a flexible approach for generating tumor cells expressing model CD8+T cell epitopes fused to endogenously encoded gene products of choice. CRISPitope-engineered tumor cells can be recognized by T cell receptor-transgenic (TCRtg) CD8+T cells widely used in immunology research. Using mice inoculated with CRISPitope-engineered tumor cells, researchers can investigate how the choice of the target antigen for T cell immunotherapies influences treatment efficacy and resistance mechanisms.

Published
2021
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41. T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels.

Author

Messmer JM, Thommek C, Piechutta M, Venkataramani V, Wehner R, Westphal D, Schubert M, Mayer CD, Effern M, Berghoff AS, Hinze D, Helfrich I, Schadendorf D, Wick W, Hölzel M, Karreman MA, and Winkler F

Abstract

To improve immunotherapy for brain tumors, it is important to determine the principal intracranial site of T cell recruitment from the bloodstream and their intracranial route to brain tumors. Using intravital microscopy in mouse models of intracranial melanoma, we discovered that circulating T cells preferably adhered and extravasated at a distinct type of venous blood vessel in the tumor vicinity, peritumoral venous vessels (PVVs). Other vascular structures were excluded as alternative T cell routes to intracranial melanomas. Anti-PD-1/CTLA-4 immune checkpoint inhibitors increased intracranial T cell motility, facilitating migration from PVVs to the tumor and subsequently inhibiting intracranial tumor growth. The endothelial adhesion molecule ICAM-1 was particularly expressed on PVVs, and, in samples of human brain metastases, ICAM-1 positivity of PVV-like vessels correlated with intratumoral T cell infiltration. These findings uncover a distinct mechanism by which the immune system can access and control brain tumors and potentially influence other brain pathologies., Competing Interests: Declaration of interests F.W. reports receiving research grants from Boehringer, Genentech, Roche, and Divide and Conquer Ltd., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2024
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