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149 results on '"Hipwell, John H."'

1. Numerical Methods for Coupled Reconstruction and Registration in Digital Breast Tomosynthesis

Author

Yang, Guang, Hipwell, John H., Hawkes, David J., and Arridge, Simon R.

Subjects
Computer Science - Computer Vision and Pattern Recognition, Physics - Medical Physics
Abstract

Digital Breast Tomosynthesis (DBT) provides an insight into the fine details of normal fibroglandular tissues and abnormal lesions by reconstructing a pseudo-3D image of the breast. In this respect, DBT overcomes a major limitation of conventional X-ray mammography by reducing the confounding effects caused by the superposition of breast tissue. In a breast cancer screening or diagnostic context, a radiologist is interested in detecting change, which might be indicative of malignant disease. To help automate this task image registration is required to establish spatial correspondence between time points. Typically, images, such as MRI or CT, are first reconstructed and then registered. This approach can be effective if reconstructing using a complete set of data. However, for ill-posed, limited-angle problems such as DBT, estimating the deformation is complicated by the significant artefacts associated with the reconstruction, leading to severe inaccuracies in the registration. This paper presents a mathematical framework, which couples the two tasks and jointly estimates both image intensities and the parameters of a transformation. We evaluate our methods using various computational digital phantoms, uncompressed breast MR images, and in-vivo DBT simulations. Firstly, we compare both iterative and simultaneous methods to the conventional, sequential method using an affine transformation model. We show that jointly estimating image intensities and parametric transformations gives superior results with respect to reconstruction fidelity and registration accuracy. Also, we incorporate a non-rigid B-spline transformation model into our simultaneous method. The results demonstrate a visually plausible recovery of the deformation with preservation of the reconstruction fidelity., Comment: 29 pages, 22 figures; The Annals of the British Machine Vision Association and Society for Pattern Recognition (BMVA) 2013

Published
2013

2. A Comparative Study of Breast Surface Reconstruction for Aesthetic Outcome Assessment

Author

Lacher, René M., Vasconcelos, Francisco, Bishop, David C., Williams, Norman R., Keshtgar, Mohammed, Hawkes, David J., Hipwell, John H., Stoyanov, Danail, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Descoteaux, Maxime, editor, Maier-Hein, Lena, editor, Franz, Alfred, editor, Jannin, Pierre, editor, Collins, D. Louis, editor, and Duchesne, Simon, editor

Published
2017
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3. Whole Mastectomy Volume Reconstruction from 2D Radiographs and Its Mapping to Histology

Author

Mertzanidou, Thomy, Hipwell, John H., Reis, Sara, Bejnordi, Babak Ehteshami, Hermsen, Meyke, Dalmis, Mehmet, Vreemann, Suzan, Platel, Bram, van der Laak, Jeroen, Karssemeijer, Nico, Mann, Ritse, Bult, Peter, Hawkes, David J., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tingberg, Anders, editor, Lång, Kristina, editor, and Timberg, Pontus, editor

Published
2016
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4. Breast Conserving Surgery Outcome Prediction: A Patient-Specific, Integrated Multi-modal Imaging and Mechano-Biological Modelling Framework

Author

Eiben, Björn, Lacher, Rene, Vavourakis, Vasileios, Hipwell, John H., Stoyanov, Danail, Williams, Norman R., Sabczynski, Jörg, Bülow, Thomas, Kutra, Dominik, Meetz, Kirsten, Young, Stewart, Barschdorf, Hans, Oliveira, Hélder P., Cardoso, Jaime S., Monteiro, João P., Zolfagharnasab, Hooshiar, Sinkus, Ralph, Gouveia, Pedro, Liefers, Gerrit-Jan, Molenkamp, Barbara, van de Velde, Cornelis J. H., Hawkes, David J., Cardoso, Maria João, Keshtgar, Mohammed, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tingberg, Anders, editor, Lång, Kristina, editor, and Timberg, Pontus, editor

Published
2016
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5. 2D-3D Registration Accuracy Estimation for Optimised Planning of Image-Guided Pancreatobiliary Interventions

Author

Hu, Yipeng, Bonmati, Ester, Gibson, Eli, Hipwell, John H., Hawkes, David J., Bandula, Steven, Pereira, Stephen P., Barratt, Dean C., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ourselin, Sebastien, editor, Joskowicz, Leo, editor, Sabuncu, Mert R., editor, Unal, Gozde, editor, and Wells, William, editor

Published
2016
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6. International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries

Author

McCormack, Valerie A., Burton, Anya, dos-Santos-Silva, Isabel, Hipwell, John H., Dickens, Caroline, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Lee, Charmaine Pei Ling, Chia, Kee-Seng, Ozmen, Vahit, Aribal, Mustafa Erkin, Flugelman, Anath Arzee, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, van Gils, Carla H., Wanders, Johanna O.P., Vinayak, Sudhir, Ndumia, Rose, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Won Lee, Jong, Kim, Jisun, Pereira, Ana, Garmendia, Maria Luisa, Sirous, Reza, Sirous, Mehri, Peplonska, Beata, Bukowska, Agnieszka, Tamimi, Rulla M., Bertrand, Kimberly, Nagata, Chisato, Kwong, Ava, Vachon, Celine, Scott, Christopher, Perez-Gomez, Beatriz, Pollan, Marina, Maskarinec, Gertraud, Giles, Graham, Hopper, John, Stone, Jennifer, Rajaram, Nadia, Teo, Soo-Hwang, Mariapun, Shivaani, Yaffe, Martin J., Schüz, Joachim, Chiarelli, Anna M., Linton, Linda, and Boyd, Norman F.

Published
2016
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7. Modelling Vascularity in Breast Cancer and Surrounding Stroma Using Diffusion MRI and Intravoxel Incoherent Motion

Author

Bailey, Colleen, Vinnicombe, Sarah, Panagiotaki, Eleftheria, Waugh, Shelley A., Hipwell, John H., Alexander, Daniel C., Kitching, Kathryn, Whelehan, Patsy, Pinder, Sarah E., Evans, Andrew, Hawkes, David J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Fujita, Hiroshi, editor, Hara, Takeshi, editor, and Muramatsu, Chisako, editor

Published
2014
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8. Characterizing Breast Phenotype with a Novel Measure of Fibroglandular Structure

Author

Hipwell, John H., Griffin, Lewis D., Whelehan, Patsy J., Song, Wenlong, Zhang, Xiying, Lesniak, Jan M., Vinnicombe, Sarah, Evans, Andy, Berg, Jonathan, Hawkes, David J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Maidment, Andrew D. A., editor, Bakic, Predrag R., editor, and Gavenonis, Sara, editor

Published
2012
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9. Intensity-Based MRI to X-ray Mammography Registration with an Integrated Fast Biomechanical Transformation

Author

Mertzanidou, Thomy, Hipwell, John H., Han, Lianghao, Taylor, Zeike, Huisman, Henkjan, Bick, Ulrich, Karssemeijer, Nico, Hawkes, David J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Maidment, Andrew D. A., editor, Bakic, Predrag R., editor, and Gavenonis, Sara, editor

Published
2012
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10. Joint Registration and Limited-Angle Reconstruction of Digital Breast Tomosynthesis

Author

Yang, Guang, Hipwell, John H., Tanner, Christine, Hawkes, David J., Arridge, Simon R., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Maidment, Andrew D. A., editor, Bakic, Predrag R., editor, and Gavenonis, Sara, editor

Published
2012
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11. Breast Shapes on Real and Simulated Mammograms

Author

Tanner, Christine, Hipwell, John H., Hawkes, David J., Székely, Gábor, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Martí, Joan, editor, Oliver, Arnau, editor, Freixenet, Jordi, editor, and Martí, Robert, editor

Published
2010
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12. Combined Reconstruction and Registration of Digital Breast Tomosynthesis

Author

Yang, Guang, Hipwell, John H., Clarkson, Matthew J., Tanner, Christine, Mertzanidou, Thomy, Gunn, Spencer, Ourselin, Sebastien, Hawkes, David J., Arridge, Simon R., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Martí, Joan, editor, Oliver, Arnau, editor, Freixenet, Jordi, editor, and Martí, Robert, editor

Published
2010
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13. The Effect of Motion Correction on Pharmacokinetic Parameter Estimation

Author

Melbourne, Andrew, Hipwell, John H., Hawkes, David J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Martí, Joan, editor, Oliver, Arnau, editor, Freixenet, Jordi, editor, and Martí, Robert, editor

Published
2010
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14. X-ray Mammography – MRI Registration Using a Volume-Preserving Affine Transformation and an EM-MRF for Breast Tissue Classification

Author

Mertzanidou, Thomy, Hipwell, John H., Cardoso, M. Jorge, Tanner, Christine, Ourselin, Sebastien, Hawkes, David J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Martí, Joan, editor, Oliver, Arnau, editor, Freixenet, Jordi, editor, and Martí, Robert, editor

Published
2010
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15. X-Ray Mammogram Registration: A Novel Validation Method

Author

Hipwell, John H., Tanner, Christine, Crum, William R., Hawkes, David J., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Astley, Susan M., editor, Brady, Michael, editor, Rose, Chris, editor, and Zwiggelaar, Reyer, editor

Published
2006
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23. Breast Conserving Surgery Outcome Prediction: A Patient-Specific, Integrated Multi-modal Imaging and Mechano-Biological Modelling Framework

Author

Eiben, Björn, primary, Lacher, Rene, additional, Vavourakis, Vasileios, additional, Hipwell, John H., additional, Stoyanov, Danail, additional, Williams, Norman R., additional, Sabczynski, Jörg, additional, Bülow, Thomas, additional, Kutra, Dominik, additional, Meetz, Kirsten, additional, Young, Stewart, additional, Barschdorf, Hans, additional, Oliveira, Hélder P., additional, Cardoso, Jaime S., additional, Monteiro, João P., additional, Zolfagharnasab, Hooshiar, additional, Sinkus, Ralph, additional, Gouveia, Pedro, additional, Liefers, Gerrit-Jan, additional, Molenkamp, Barbara, additional, van de Velde, Cornelis J. H., additional, Hawkes, David J., additional, Cardoso, Maria João, additional, and Keshtgar, Mohammed, additional

Published
2016
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24. Whole Mastectomy Volume Reconstruction from 2D Radiographs and Its Mapping to Histology

Author

Mertzanidou, Thomy, primary, Hipwell, John H., additional, Reis, Sara, additional, Bejnordi, Babak Ehteshami, additional, Hermsen, Meyke, additional, Dalmis, Mehmet, additional, Vreemann, Suzan, additional, Platel, Bram, additional, van der Laak, Jeroen, additional, Karssemeijer, Nico, additional, Mann, Ritse, additional, Bult, Peter, additional, and Hawkes, David J., additional

Published
2016
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25. Modelling Vascularity in Breast Cancer and Surrounding Stroma Using Diffusion MRI and Intravoxel Incoherent Motion

Author

Bailey, Colleen, primary, Vinnicombe, Sarah, additional, Panagiotaki, Eleftheria, additional, Waugh, Shelley A., additional, Hipwell, John H., additional, Alexander, Daniel C., additional, Kitching, Kathryn, additional, Whelehan, Patsy, additional, Pinder, Sarah E., additional, Evans, Andrew, additional, and Hawkes, David J., additional

Published
2014
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26. A new validation method for X-ray mammogram registration algorithms using a projection model of breast X-ray compression

Author

Hipwell, John H., Tanner, Christine, Crum, William R., Schnabel, Julia A., and Hawkes, David J.

Subjects
Mammography -- Equipment and supplies, Image processing -- Methods, Diagnostic imaging -- Research, Business, Electronics, Electronics and electrical industries, Health care industry
Abstract

Establishing spatial correspondence between features visible in X-ray mammograms obtained at different times has great potential to aid assessment and quantitation of change in the breast indicative of malignancy. The literature contains numerous nonrigid registration algorithms developed for this purpose, but existing approaches are flawed by the assumption of inappropriate 2-D transformation models and quantitative estimation of registration accuracy is limited. In this paper, we describe a novel validation method which simulates plausible mammographic compressions of the breast using a magnetic resonance imaging (MRI) derived finite element model. By projecting the resulting known 3-D displacements into 2-D and generating pseudo-mammograms from these same compressed magnetic resonance (MR) volumes, we can generate convincing images with known 2-D displacements with which to validate a registration algorithm. We illustrate this approach by computing the accuracy for two conventional nonrigid 2-D registration algorithms applied to mammographic test images generated from three patient MR datasets. We show that the accuracy of these algorithms is close to the best achievable using a 2-D one-to-one correspondence model but that new algorithms incorporating more representative transformation models are required to achieve sufficiently accurate registrations for this application. Index Terms--Biomedical X-ray imaging, image registration, mammography, modeling, validation.

Published
2007

27. Postoperative calculation of acetabular cup position using 2-D-3-D registration

Author

Penney, Graeme P., Edwards, Philip J., Hipwell, John H., Slomczykowski, Mike, Revie, Ian, and Hawkes, David J.

Subjects
Bones -- Medical examination, Pelvis -- Medical examination, Artificial bones -- Usage, Tomography -- Usage, Biological sciences, Business, Computers, Health care industry
Abstract

A method to accurately measure the position and orientation of an acetabular cup implant from postoperative X-rays has been designed and validated. The method uses 2-D-3-D registration to align both the prosthesis and the preoperative computed tomography (CT) volume to the X-ray image. This allows the position of the implant to be calculated with respect to a CT-based surgical plan. Experiments have been carried out using ten sets of patient data. A conventional plain-film measurement technique was also investigated. A gold standard implant position and orientation was calculated using postoperative CT. Results show our method to be significantly more accurate than the plain-film method for calculating cup anteversion. Cup orientation and position could be measured to within a mean absolute error of 1.4 mm or degrees. Index Terms--Cup anteversion, implant position, 2-D-3-D registration.

Published
2007

31. Intensity-based 2-D--3-D registration of cerebral angiograms

Author

Hipwell, John H., Penney, Graeme P., McLaughlin, Robert A., Rhode, Kawal, Summers, Paul, Cox, Tim C., Byrne, James V., Noble, J. Alison, and Hawkes, David J.

Subjects
Angiography -- Research, Business, Electronics, Electronics and electrical industries, Health care industry
Abstract

We propose a new method for aligning three-dimensional (3-D) magnetic resonance angiography (MRA) with 2-D X-ray digital subtraction angiograms (DSA). Our method is developed from our algorithm to register computed tomography volumes to X-ray images based on intensity matching of digitally reconstructed radiographs (DRRs). To make the DSA and DRR more similar, we transform the MRA images to images of the vasculature and set to zero the contralateral side of the MRA to that imaged with DSA. We initialize the search for a match on a user defined circular region of interest. We have tested six similarity measures using both unsegmented MRA and three segmentation variants of the MRA. Registrations were carried out on images of a physical neuro-vascular phantom and images obtained during four neuro-vascular interventions. The most accurate and robust registrations were obtained using the pattern intensity, gradient difference, and gradient correlation similarity measures, when used in conjunction with the most sophisticated MRA segmentations. Using these measures, 95 % of the phantom start positions and 82 % of the clinical start positions were successfully registered. The lowest root mean square reprojection errors were 1.3 mm (standard deviation 0.6) for the phantom and 1.5 mm (standard deviation 0.9) for the clinical data sets. Finally, we present a novel method for the comparison of similarity measure performance using a technique borrowed from receiver operator characteristic analysis. Index Terms--2-D--3-D registration, digital subtraction angiography, magnetic resonance angiography, neuro-interventions, similarity measures.

Published
2003

39. Microstructural models for diffusion MRI in breast cancer and surrounding stroma:an ex vivo study

Author

Bailey, Colleen, Siow, Bernard, Panagiotaki, Eleftheria, Hipwell, John H., Mertzanidou, Thomy, Owen, Julie, Gazinska, Patrycja, Pinder, Sarah E., Alexander, Daniel C., and Hawkes, David J.

Subjects
diffusion, Reproducibility of Results, Breast Neoplasms, restriction, anisotropy, Magnetic Resonance Imaging, Models, Biological, Sensitivity and Specificity, Diffusion Tensor Imaging, breast cancer, Connective Tissue, DTI, Image Interpretation, Computer-Assisted, Tumor Cells, Cultured, ex vivo, Humans, Computer Simulation, Female, Research Articles, Research Article, MRI
Abstract

The diffusion signal in breast tissue has primarily been modelled using apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and diffusion tensor (DT) models, which may be too simplistic to describe the underlying tissue microstructure. Formalin-fixed breast cancer samples were scanned using a wide range of gradient strengths, durations, separations and orientations. A variety of one- and two-compartment models were tested to determine which best described the data. Models with restricted diffusion components and anisotropy were selected in most cancerous regions and there were no regions in which conventional ADC or DT models were selected. Maps of ADC generally related to cellularity on histology, but maps of parameters from more complex models suggest that both overall cell volume fraction and individual cell size can contribute to the diffusion signal, affecting the specificity of ADC to the tissue microstructure. The areas of coherence in diffusion anisotropy images were small, approximately 1 mm, but the orientation corresponded to stromal orientation patterns on histology.

Published
2017
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40. Multiscale Mechano-Biological Finite Element Modelling of Oncoplastic Breast Surgery-Numerical Study towards Surgical Planning and Cosmetic Outcome Prediction

Author

Vavourakis, Vasileios, Eiben, Bjoern, Hipwell, John H., Williams, Norman R., Keshtgar, Mo, and Hawkes, David J.

Subjects
Biophysical Simulations, Physiology, Imaging Techniques, Finite Element Analysis, Biophysics, lcsh:Medicine, Surgical and Invasive Medical Procedures, Breast Neoplasms, Research and Analysis Methods, Cardiovascular Physiology, Mastectomy, Segmental, Patient Care Planning, Diagnostic Radiology, Mathematical and Statistical Techniques, Diagnostic Medicine, Tissue Repair, Medicine and Health Sciences, Humans, lcsh:Science, Wound Healing, Damage Mechanics, Neovascularization, Pathologic, Mathematical Models, Radiology and Imaging, Physics, lcsh:R, Reproductive System, Biology and Life Sciences, Classical Mechanics, Computational Biology, Magnetic Resonance Imaging, Deformation, Biomechanical Phenomena, Treatment Outcome, Physical Sciences, Female, lcsh:Q, Angiogenesis, Anatomy, Physiological Processes, Breast Tissue, Research Article, Developmental Biology
Abstract

Surgical treatment for early-stage breast carcinoma primarily necessitates breast conserving therapy (BCT), where the tumour is removed while preserving the breast shape. To date, there have been very few attempts to develop accurate and efficient computational tools that could be used in the clinical environment for pre-operative planning and oncoplastic breast surgery assessment. Moreover, from the breast cancer research perspective, there has been very little effort to model complex mechano-biological processes involved in wound healing. We address this by providing an integrated numerical framework that can simulate the therapeutic effects of BCT over the extended period of treatment and recovery. A validated, three-dimensional, multiscale finite element procedure that simulates breast tissue deformations and physiological wound healing is presented. In the proposed methodology, a partitioned, continuum-based mathematical model for tissue recovery and angiogenesis, and breast tissue deformation is considered. The effectiveness and accuracy of the proposed numerical scheme is illustrated through patient-specific representative examples. Wound repair and contraction numerical analyses of real MRI-derived breast geometries are investigated, and the final predictions of the breast shape are validated against post-operative follow-up optical surface scans from four patients. Mean (standard deviation) breast surface distance errors in millimetres of 3.1 (±3.1), 3.2 (±2.4), 2.8 (±2.7) and 4.1 (±3.3) were obtained, demonstrating the ability of the surgical simulation tool to predict, pre-operatively, the outcome of BCT to clinically useful accuracy.

Published
2016

44. Mammographic density and ageing : A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Author

Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M, Bertrand, Kimberly A, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham G., Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H, Wanders, Johanna Olga Pauline, Sirous, Reza, Sirous, Mehri, Hipwell, John H, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee Seng, Scott, Christopher, Chiarelli, Anna M, Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie, Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M, Bertrand, Kimberly A, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham G., Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H, Wanders, Johanna Olga Pauline, Sirous, Reza, Sirous, Mehri, Hipwell, John H, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee Seng, Scott, Christopher, Chiarelli, Anna M, Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie

Published
2017

45. Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M, Bertrand, Kimberly A, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham G., Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H, Wanders, Johanna Olga Pauline, Sirous, Reza, Sirous, Mehri, Hipwell, John H, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee Seng, Scott, Christopher, Chiarelli, Anna M, Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M, Bertrand, Kimberly A, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham G., Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H, Wanders, Johanna Olga Pauline, Sirous, Reza, Sirous, Mehri, Hipwell, John H, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee Seng, Scott, Christopher, Chiarelli, Anna M, Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie

Published
2017

46. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

Author

Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie A, Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie A

Published
2016

47. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie A, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie A

Published
2016

49. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

Author

Burton, Anya, primary, Byrnes, Graham, additional, Stone, Jennifer, additional, Tamimi, Rulla M., additional, Heine, John, additional, Vachon, Celine, additional, Ozmen, Vahit, additional, Pereira, Ana, additional, Garmendia, Maria Luisa, additional, Scott, Christopher, additional, Hipwell, John H., additional, Dickens, Caroline, additional, Schüz, Joachim, additional, Aribal, Mustafa Erkin, additional, Bertrand, Kimberly, additional, Kwong, Ava, additional, Giles, Graham G., additional, Hopper, John, additional, Pérez Gómez, Beatriz, additional, Pollán, Marina, additional, Teo, Soo-Hwang, additional, Mariapun, Shivaani, additional, Taib, Nur Aishah Mohd, additional, Lajous, Martín, additional, Lopez-Riduara, Ruy, additional, Rice, Megan, additional, Romieu, Isabelle, additional, Flugelman, Anath Arzee, additional, Ursin, Giske, additional, Qureshi, Samera, additional, Ma, Huiyan, additional, Lee, Eunjung, additional, Sirous, Reza, additional, Sirous, Mehri, additional, Lee, Jong Won, additional, Kim, Jisun, additional, Salem, Dorria, additional, Kamal, Rasha, additional, Hartman, Mikael, additional, Miao, Hui, additional, Chia, Kee-Seng, additional, Nagata, Chisato, additional, Vinayak, Sudhir, additional, Ndumia, Rose, additional, van Gils, Carla H., additional, Wanders, Johanna O. P., additional, Peplonska, Beata, additional, Bukowska, Agnieszka, additional, Allen, Steve, additional, Vinnicombe, Sarah, additional, Moss, Sue, additional, Chiarelli, Anna M., additional, Linton, Linda, additional, Maskarinec, Gertraud, additional, Yaffe, Martin J., additional, Boyd, Norman F., additional, dos-Santos-Silva, Isabel, additional, and McCormack, Valerie A., additional

Published
2016
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