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Your search keyword '"Hirai, Ryoji"' showing total 102 results
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102 results on '"Hirai, Ryoji"'

5. OK-432 injection therapy for cystadenocarcinoma of the parotid gland: a case report

Author

Makiyama, Kiyoshi, Hirai, Ryoji, Iikuni, Fusako, Ikeda, Atsuo, and Tomomatsu, Hirotaka

Subjects
Adenocarcinoma -- Research -- Care and treatment -- Complications and side effects, Deglutition disorders -- Research -- Risk factors, Immunity -- Research -- Influence, Health
Abstract

Abstract OK-432 is an immunomodulator that has been reported to be efficacious as an injection therapy for cervical lymphomas and ranulas. We performed OK-432 injection therapy to treat a cystadenocarcinoma [...]

Published
2016

18. Efficacy of a silicone plug for patulous eustachian tube: A prospective, multicenter case series.

Author

Ikeda, Ryoukichi, Oshima, Takeshi, Mizuta, Kunihiro, Arai, Maki, Endo, Shiori, Hirai, Ryoji, Ikeda, Koji, Kadota, Satoki, Otsuka, Yuki, Yamaguchi, Takuhiro, Kawase, Tetsuaki, and Kobayashi, Toshimitsu

Abstract

Objectives/hypothesis: To report the efficacy and safety of transtympanic plugging of the eustachian tube (ET) using a silicone plug (Kobayashi plug) for chronic patulous ET (PET).Study Design: Prospective and multicenter trial conducted in which 30 PET patients were resistant to at least 6 months of conservative treatment.Methods: The efficacy and safety of 28 and 27 patients, respectively, were analyzed. All patients fulfilled inclusion and exclusion criteria. The primary end point used the patulous eustachian tube handicap inventory-10 (PHI-10), and the secondary end point used ET function tests such as sonotubometry, tubo-tympano-aerodynamic-graphy, and respiratory movement of the tympanic membrane and auscultation of voice sounds transmitted from the nose through the ET to the external auditory canal at 3months after surgery.Results: PHI-10 scores were 34.4 ± 4.2, 6.4 ± 9, and 5.7 ± 8.6 at screening, and 3 and 6 months after surgery. Twenty-three cases (82.1%, 95% confidence interval: 63.1%-93.9%) were judged as successes. There were five cases (17.2%) of middle ear effusion, four cases (13.8%) of tympanic membrane perforation, and one case of tinnitus due to surgery to remove the plug. No severe or life-threatening complications were found.Conclusions: This study revealed the efficacy and safety of silicone plug insertion for severe PET patients.Level Of Evidence: 2 Laryngoscope, 130:1304-1309, 2020. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Multi-Year Effect of Human Papillomavirus Vaccination on Recurrent Respiratory Papillomatosis.

Author

Matsuzaki, Hiroumi, Makiyama, Kiyoshi, Hirai, Ryoji, Suzuki, Hirotaka, Asai, Ryohei, and Oshima, Takeshi

Abstract

Objective: To examine whether human papilloma virus (HPV) vaccination in combination with surgical resection could suppress recurrence for an extended period of time in patients with recurrent respiratory papillomatosis (RRP).Methods: In a prospective case series, data of patients who received combination therapy comprising surgery and quadrivalent HPV vaccination (Gardasil; Merck & Co., West Point, PA) were collected. Patients were followed up for RRP from March 2012 to July 2018 in an academic tertiary care center. The patients comprised 16 adults with RRP who were observed for >12 months after HPV vaccination, and whose HPV-DNA status was tested before and for >12 months after completion of combination therapy. The outcomes of this study were the severity score of larynx disease, tumor incidence rate, and relationship between this rate and HPV-DNA negative conversion after therapy.Results: The severity score of laryngeal disease significantly decreased from before combination therapy to the time of final examination (P = 0.00045). The tumor incidence rate decreased to approximately 20% during the period from 12 to 47 months after HPV vaccination. Regarding HPV-DNA status in the final test results of each patient, 12 of 16 (75%) patients showed negative conversion; these 12 were significantly less likely to experience recurrence than patients who persistently tested positive for HPV-DNA during the period between 12 and 47 months after vaccination.Conclusion: HPV vaccination prevented recurrence associated with RRP surgery for 4 years in 80% of patients. This may be an effective adjuvant therapy, and HPV-DNA negative conversion after HPV vaccination might predict prevention of recurrence.Level Of Evidence: 2 Laryngoscope, 130:442-447, 2020. [ABSTRACT FROM AUTHOR]

Published
2020
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41. A Case of Multiple Sclerosis in which Vertigo was the Chief Complaint

Author

Toi, Teruo, primary, Nomura, Yasuyuki, additional, Asakawa, Takeshi, additional, Shigihara, Shuntaro, additional, Masuda, Takeshi, additional, Hirai, Ryoji, additional, Ikeda, Atsuo, additional, Kishi, Hiroyuki, additional, Shiba, Kazutaka, additional, Matsuyama, Kazuo, additional, Ikeda, Minoru, additional, and Mizutani, Tomohiko, additional

Published
2009
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43. Moving Towards a Better Hospital and Workplace

Author

Nomura, Yasuyuki, primary, Hamada, Naoko, additional, Matsuyama, Kazuo, additional, Kudo, Itsuhiro, additional, Matsuzaki, Hiroumi, additional, Sekine, Hiroki, additional, Hirai, Ryoji, additional, Asakawa, Takeshi, additional, Noguchi, Yugo, additional, Tsuji, Kenzo, additional, Shigihara, Shuntaro, additional, and Ikeda, Minoru, additional

Published
2008
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