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159 results on '"Hiram, Roddy"'

14. Alterations of Myocardial Mitochondrial Morphology and Function in a Canine Model of Premature Ventricular Contractions-Induced Cardiomyopathy

Author

Liu, Tao, primary, Yang, Manqi, primary, Cui, Bo, primary, Ju, Hao, primary, Wu, Jinchun, primary, Ren, Zongli, primary, Cao, Sheng, primary, Yan, Min, primary, Zhang, Fan, primary, Liu, Zheyu, primary, He, Shuijing, primary, Zhang, Jiajun, primary, Hiram, Roddy, primary, Xiong, Feng, primary, Cheng, Mian, primary, and Wu, Gang, primary

Published
2024
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15. The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology

Author

Mehdizadeh, Mozhdeh, Naud, Patrice, Abu-Taha, Issam H., Hiram, Roddy, Xiong, Feng, Xiao, Jiening, Saljic, Arnela, Kamler, Markus, Vuong-Robillard, Nhung, Thorin, Eric, Ferbeyre, Gerardo, Tardif, Jean Claude, Sirois, Martin G., Tanguay, Jean Francois, Dobrev, Dobromir, Nattel, Stanley, Mehdizadeh, Mozhdeh, Naud, Patrice, Abu-Taha, Issam H., Hiram, Roddy, Xiong, Feng, Xiao, Jiening, Saljic, Arnela, Kamler, Markus, Vuong-Robillard, Nhung, Thorin, Eric, Ferbeyre, Gerardo, Tardif, Jean Claude, Sirois, Martin G., Tanguay, Jean Francois, Dobrev, Dobromir, and Nattel, Stanley

Abstract

AIMS: Cellular senescence is a stress-related or aging response believed to contribute to many cardiac conditions; however, its role in atrial fibrillation (AF) is unknown. Age is the single most important determinant of the risk of AF. The present study was designed to (i) evaluate AF susceptibility and senescence marker expression in rat models of aging and myocardial infarction (MI), (ii) study the effect of reducing senescent-cell burden with senolytic therapy on the atrial substrate in MI rats, and (iii) assess senescence markers in human atrial tissue as a function of age and the presence of AF. METHODS AND RESULTS: AF susceptibility was studied with programmed electrical stimulation. Gene and protein expression was evaluated by immunoblot or immunofluorescence (protein) and digital polymerase chain reaction (PCR) or reverse transcriptase quantitative PCR (messenger RNA). A previously validated senolytic combination, dasatinib and quercetin, (D+Q; or corresponding vehicle) was administered from the time of sham or MI surgery through 28 days later. Experiments were performed blinded to treatment assignment. Burst pacing-induced AF was seen in 100% of aged (18-month old) rats, 87.5% of young MI rats, and 10% of young control (3-month old) rats (P ≤ 0.001 vs. each). Conduction velocity was slower in aged [both left atrium (LA) and right atrium (RA)] and young MI (LA) rats vs. young control rats (P ≤ 0.001 vs. each). Atrial fibrosis was greater in aged (LA and RA) and young MI (LA) vs. young control rats (P < 0.05 for each). Senolytic therapy reduced AF inducibility in MI rats (from 8/9 rats, 89% in MI vehicle, to 0/9 rats, 0% in MI D + Q, P < 0.001) and attenuated LA fibrosis. Double staining suggested that D + Q acts by clearing senescent myofibroblasts and endothelial cells. In human atria, senescence markers were upregulated in older (≥70 years) and long-standing AF patients vs. individuals ≤60 and sinus rhythm controls, respectively. CONCLUSION: Our

Published
2024

16. An inflammation resolution–promoting intervention prevents atrial fibrillation caused by left ventricular dysfunction

Author

Hiram, Roddy, Xiong, Feng, Naud, Patrice, Xiao, Jiening, Sosnowski, Deanna K., Le Quilliec, Ewen, Saljic, Arnela, Abu-Taha, Issam H., Kamler, Markus, LeBlanc, Charles Alexandre, Al-UDatt, Doaa G.F., Sirois, Martin G., Hebert, Terence E., Tanguay, Jean François, Tardif, Jean Claude, Dobrev, Dobromir, Nattel, Stanley, Hiram, Roddy, Xiong, Feng, Naud, Patrice, Xiao, Jiening, Sosnowski, Deanna K., Le Quilliec, Ewen, Saljic, Arnela, Abu-Taha, Issam H., Kamler, Markus, LeBlanc, Charles Alexandre, Al-UDatt, Doaa G.F., Sirois, Martin G., Hebert, Terence E., Tanguay, Jean François, Tardif, Jean Claude, Dobrev, Dobromir, and Nattel, Stanley

Abstract

Aims Recent studies suggest that bioactive mediators called resolvins promote an active resolution of inflammation. Inflammatory signalling is involved in the development of the substrate for atrial fibrillation (AF). The aim of this study is to evaluate the effects of resolvin-D1 on atrial arrhythmogenic remodelling resulting from left ventricular (LV) dysfunction induced by myocardial infarction (MI) in rats. ......................................................................................................................................................................................................Methods MI was produced by left anterior descending coronary artery ligation. Intervention groups received daily intraperitoneal resolvin- and results D1, beginning before MI surgery (early-RvD1) or Day 7 post-MI (late-RvD1) and continued until Day 21 post-MI. AF vulnerability was evaluated by performing an electrophysiological study. Atrial conduction was analysed by using optical mapping. Fibrosis was quantified by Masson’s trichrome staining and gene expression by quantitative polymerase chain reaction and RNA sequencing. Investigators were blinded to group identity. Early-RvD1 significantly reduced MI size (17 ± 6%, vs. 39 ± 6% in vehicle-MI) and preserved LV ejection fraction; these were unaffected by late-RvD1. Transoesophageal pacing induced atrial tachyarrhythmia in 2/18 (11%) sham-operated rats, vs. 18/18 (100%) MI-only rats, in 5/18 (28%, P < 0.001 vs. MI) early-RvD1 MI rats, and in 7/12 (58%, P < 0.01) late-RvD1 MI rats. Atrial conduction velocity significantly decreased post-MI, an effect suppressed by RvD1 treatment. Both early-RvD1 and late-RvD1 limited MI-induced atrial fibrosis and prevented MI-induced increases in the atrial expression of inflammation-related and fibrosis-related biomarkers and pathways. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Published
2024

17. Atrial Cardiomyocytes contribute to the Inflammatory Status associated with Atrial Fibrillation in Right Heart Disease

Author

Le Quilliec, Ewen, primary, LeBlanc, Charles-Alexandre, additional, Neuilly, Orlane, additional, Xiao, Jiening, additional, Younes, Rim, additional, Altuntas, Yasemin, additional, Xiong, Feng, additional, Naud, Patrice, additional, Villeneuve, Louis, additional, Sirois, Martin G, additional, Tanguay, Jean-François, additional, Tardif, Jean-Claude, additional, and Hiram, Roddy, additional

Published
2024
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18. The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology

Author

Mehdizadeh, Mozhdeh, primary, Naud, Patrice, additional, Abu-Taha, Issam H, additional, Hiram, Roddy, additional, Xiong, Feng, additional, Xiao, Jiening, additional, Saljic, Arnela, additional, Kamler, Markus, additional, Vuong-Robillard, Nhung, additional, Thorin, Eric, additional, Ferbeyre, Gerardo, additional, Tardif, Jean-Claude, additional, Sirois, Martin G, additional, Tanguay, Jean Francois, additional, Dobrev, Dobromir, additional, and Nattel, Stanley, additional

Published
2024
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19. An inflammation resolution–promoting intervention prevents atrial fibrillation caused by left ventricular dysfunction

Author

Hiram, Roddy, primary, Xiong, Feng, additional, Naud, Patrice, additional, Xiao, Jiening, additional, Sosnowski, Deanna K, additional, Le Quilliec, Ewen, additional, Saljic, Arnela, additional, Abu-Taha, Issam H, additional, Kamler, Markus, additional, LeBlanc, Charles-Alexandre, additional, Al-U’Datt, Doa’a G F, additional, Sirois, Martin G, additional, Hebert, Terence E, additional, Tanguay, Jean-François, additional, Tardif, Jean-Claude, additional, Dobrev, Dobromir, additional, and Nattel, Stanley, additional

Published
2023
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20. Atrial cardiomyocytes contribute to the inflammatory status associated with atrial fibrillation in right heart disease.

Author

Quilliec, Ewen Le, LeBlanc, Charles-Alexandre, Neuilly, Orlane, Xiao, Jiening, Younes, Rim, Altuntas, Yasemin, Xiong, Feng, Naud, Patrice, Villeneuve, Louis, Sirois, Martin G, Tanguay, Jean-François, Tardif, Jean-Claude, and Hiram, Roddy

Abstract

Aims Right heart disease (RHD), characterized by right ventricular (RV) and atrial (RA) hypertrophy, and cardiomyocytes' (CM) dysfunctions have been described to be associated with the incidence of atrial fibrillation (AF). Right heart disease and AF have in common, an inflammatory status, but the mechanisms relating RHD, inflammation, and AF remain unclear. We hypothesized that right heart disease generates electrophysiological and morphological remodelling affecting the CM, leading to atrial inflammation and increased AF susceptibility. Methods and results Pulmonary artery banding (PAB) was surgically performed (except for sham) on male Wistar rats (225–275 g) to provoke an RHD. Twenty-one days (D21) post-surgery, all rats underwent echocardiography and electrophysiological studies (EPS). Optical mapping was performed in situ , on Langendorff-perfused hearts. The contractility of freshly isolated CM was evaluated and recorded during 1 Hz pacing in vitro. Histological analyses were performed on formalin-fixed RA to assess myocardial fibrosis, connexin-43 levels, and CM morphology. Right atrial levels of selected genes and proteins were obtained by qPCR and Western blot, respectively. Pulmonary artery banding induced severe RHD identified by RV and RA hypertrophy. Pulmonary artery banding rats were significantly more susceptible to AF than sham. Compared to sham RA CM from PAB rats were significantly elongated and hypercontractile. Right atrial CM from PAB animals showed significant augmentation of mRNA and protein levels of pro-inflammatory interleukin (IL)-6 and IL1β. Sarcoplasmic–endoplasmic reticulum Ca2+-ATPase-2a (SERCA2a) and junctophilin-2 were decreased in RA CM from PAB compared to sham rats. Conclusions Right heart disease-induced arrhythmogenicity may occur due to dysfunctional SERCA2a and inflammatory signalling generated from injured RA CM, which leads to an increased risk of AF. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Resolving Unchecked Inflammation in Atrial Fibrillation

Author

Sosnowski, Deanna, primary, Hiram, Roddy, additional, Qi, Xiao Yan, additional, Bourque, Kyla, additional, Naud, Patrice, additional, Ninni, Sandro, additional, Pétrin, Darlaine, additional, Hebert, Terry, additional, and Nattel, Stanley, additional

Published
2023
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23. PO-02-243 IMPACT OF PARTIAL CONSTRICTION OF THE ARTERIAL PULMONARY TRUNK ON THE DEVELOPMENT OF SUSCEPTIBILITY TO ATRIAL FIBRILLATION IN RATS

Author

LeBlanc, Charles-Alexandre, primary, Le Quilliec, Ewen, additional, Altuntas, Yasemin, additional, Xiong, Feng, additional, Younes, RIm, additional, Naud, Patrice, additional, Higgins, Marie-Ève, additional, Shi, Yan F., additional, Sirois, Martin G., additional, Tanguay, Jean-François, additional, Tardif, Jean-Claude, additional, and Hiram, Roddy, additional

Published
2023
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24. Evolution of atrial remodeling and atrial arrhythmogenicity in a rat model of chronic pulmonary artery constriction: A “trialogue” between right heart disease, cardiac inflammation, and atrial fibrillation inducibility

Author

LeBlanc, Charles-Alexandre, primary, Le Quilliec, Ewen, additional, Altuntas, Yasemin, additional, Xiong, Feng, additional, Younes, Rim, additional, Fundere, Alexia, additional, Naud, Patrice, additional, Higgins, Marie-Ève, additional, Roy, Colombe, additional, Shi, Yan Fen, additional, Martin, Sirois, additional, Tanguay, Jean-François, additional, Tardif, Jean-Claude, additional, and Hiram, Roddy, additional

Published
2023
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25. Atrial cardiomyocytes orchestrate the development of profibrotic inflammatory profile associated with atrial fibrillation vulnerability

Author

Le Quilliec, Ewen, primary, LeBlanc, Charles-Alexandre, additional, Younes, Rim, additional, Xiong, Feng, additional, Naud, Patrice, additional, Villeneuve, Louis, additional, Roy, Colombe, additional, Shi, Yan Fen, additional, Sirois, Martin, additional, Tanguay, Jean-François, additional, Tardif, Jean-Claude, additional, and Hiram, Roddy, additional

Published
2023
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26. PO-01-155 THE ELECTROPHYSIOLOGICAL AND MORPHOLOGICAL REMODELING AFFECTING ATRIAL CARDIOMYOCYTES IN RIGHT HEART DISEASE ARE ASSOCIATED WITH A PARTICULAR INFLAMMATORY PROFILE LEADING TO THE DEVELOPMENT OF AF SUBSTRATE

Author

Le Quilliec, Ewen, primary, LeBlanc, Charles-Alexandre, additional, Younes, Rim, additional, Xiong, Feng, additional, Roy, Colombe, additional, Shi, Yan-Fen, additional, Sirois, Martin G., additional, Tanguay, Jean-François, additional, Tardif, Jean-Claude, additional, and Hiram, Roddy, additional

Published
2023
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27. Involvement and possible role of transglutaminases 1 and 2 in mediating fibrotic signalling, collagen cross-linking and cell proliferation in neonatal rat ventricular fibroblasts

Author

Al-U’datt, Doa’a G. F., primary, Tranchant, Carole C., additional, Al-Husein, Belal, additional, Hiram, Roddy, additional, Al-Dwairi, Ahmed, additional, AlQudah, Mohammad, additional, Al-shboul, Othman, additional, Jaradat, Saied, additional, Alqbelat, Jenan, additional, and Almajwal, Ali, additional

Published
2023
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34. PO-616-07 THE ROLE OF CELLULAR SENESCENCE IN ATRIAL FIBRILLATION

Author

Mehdizadeh, Mozhdeh, primary, Naud, Patrice, additional, Hiram, Roddy, additional, Xiong, Feng, additional, Ferbeyre, Gerardo, additional, Tanguay, Jean-François, additional, Sirois, Martin G., additional, Thorin, Eric, additional, Tardif, Jean-Claude, additional, and Nattel, Stanley, additional

Published
2022
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35. Additional file 6 of Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling

Author

Wu, Jinchun, Liu, Tao, Shi, Shaobo, Fan, Zhixing, Hiram, Roddy, Xiong, Feng, Cui, Bo, Su, Xiaoling, Chang, Rong, Zhang, Wei, Yan, Min, Tang, Yanhong, Huang, He, Wu, Gang, and Huang, Congxin

Abstract

Additional file 6: Table S1. Animal and organ characteristics in the four groups of rats.

Published
2022
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36. Additional file 7 of Dapagliflozin reduces the vulnerability of rats with pulmonary arterial hypertension-induced right heart failure to ventricular arrhythmia by restoring calcium handling

Author

Wu, Jinchun, Liu, Tao, Shi, Shaobo, Fan, Zhixing, Hiram, Roddy, Xiong, Feng, Cui, Bo, Su, Xiaoling, Chang, Rong, Zhang, Wei, Yan, Min, Tang, Yanhong, Huang, He, Wu, Gang, and Huang, Congxin

Abstract

Additional file 7: Table S2. Echocardiographic parameters of the four groups of rats.

Published
2022
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45. Ultrasonically Enhanced Cardioprotective Effects of Royal Jelly Targeting Molecular and Cellular Signaling in Cardiac Fibroblasts

Author

Al-u&apos;datt, Doa&apos;a, primary, Alu&apos;datt, Muhammad H., additional, Tranchant, Carole C. C., additional, Hiram, Roddy, additional, Al-Dwairi, Ahmed, additional, AlQudah, Mohammad, additional, Al-shboul, Othman, additional, Elsalem, Lina, additional, Jaradat, Saied, additional, and Alqbelat, Jenan, additional

Published
2022
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