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11 results on '"Hirano, Touko"'

2. Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases

Author

Blomme, Arnaud, Van Simaeys, Gaetan, Doumont, Gilles, Costanza, Brunella, Bellier, Justine, Otaka, Yukihiro, Sherer, Félicie, Lovinfosse, Pierre, Boutry, Sébastien, Palacios, Ana Perez, De Pauw, Edwin, Hirano, Touko, Yokobori, Takehiko, Hustinx, Roland, Bellahcène, Akeila, Delvenne, Philippe, Detry, Olivier, Goldman, Serge, Nishiyama, Masahiko, Castronovo, Vincent, and Turtoi, Andrei

Published
2018
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3. Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats

Author

Jiang, Weiru, primary, Kakizaki, Toshikazu, additional, Fujihara, Kazuyuki, additional, Miyata, Shigeo, additional, Zhang, Yue, additional, Suto, Takashi, additional, Kato, Daiki, additional, Saito, Shigeru, additional, Shibasaki, Koji, additional, Ishizaki, Yasuki, additional, Isoda, Koji, additional, Yokoo, Hideaki, additional, Obinata, Hideru, additional, Hirano, Touko, additional, Miyasaka, Yoshiki, additional, Mashimo, Tomoji, additional, and Yanagawa, Yuchio, additional

Published
2021
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4. Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice

Author

Wada, Eri, primary, Kobayashi, Masaki, additional, Kohno, Daisuke, additional, Kikuchi, Osamu, additional, Suga, Takayoshi, additional, Matsui, Sho, additional, Yokota-Hashimoto, Hiromi, additional, Honzawa, Norikiyo, additional, Ikeuchi, Yuichi, additional, Tsuneoka, Haruka, additional, Hirano, Touko, additional, Obinata, Hideru, additional, Sasaki, Tsutomu, additional, and Kitamura, Tadahiro, additional

Published
2021
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5. Loss of function in mouse GAD67 leads to emotional impairments

Author

Miyata, Shigeo, primary, Kakizaki, Toshikazu, additional, Fujihara, Kazuyuki, additional, Obinata, Hideru, additional, Hirano, Touko, additional, Nakai, Junichi, additional, Tanaka, Mika, additional, Itohara, Shigeyoshi, additional, Tanaka, Kenji, additional, Watanabe, Masahiko, additional, Abe, Manabu, additional, Sakimura, Kenji, additional, and Yanagawa, Yuchio, additional

Published
2021
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6. Global Knockdown of Glutamate Decarboxylase 67 Elicits Emotional and Auditory Abnormalities in Mice

Author

Miyata, Shigeo, primary, Kakizaki, Toshikazu, additional, Fujihara, Kazuyuki, additional, Obinata, Hideru, additional, Hirano, Touko, additional, Nakai, Junichi, additional, Tanaka, Mika, additional, Itohara, Shigeyoshi, additional, Watanabe, Masahiko, additional, Tanaka, Kenji F, additional, Abe, Manabu, additional, Sakimura, Kenji, additional, and Yanagawa, Yuchio, additional

Published
2020
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8. Innovative methodology for the identification of soluble biomarkers in fresh tissues

Author

Costanza, Brunella, Turtoi, Andrei, Bellahcene, Akeila, Hirano, Touko, Peulen, Olivier, Blomme, Arnaud, Hennequière, Vincent, Mutijima, Eugene, Boniver, Jacques, Meuwis, Marie-Alice, Josse, Claire, Koopmansch, Benjamin, Segers, Karin, Yokobori, Takehiko, Fahmy, Karim, Thiry, Marc, Coimbra, Carla, Garbacki, Nancy, Colige, Alain, Baiwir, Dominique, Bours, Vincent, Louis, Edouard, Detry, Olivier, Delvenne, Philippe, Nishiyama, Masahiko, Castronovo, Vincent, Université de Liège, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Liège (CHU-Liège), and Herrada, Anthony

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.CAN] Life Sciences [q-bio]/Cancer, miRNAs, biomarkers, [SDV.CAN]Life Sciences [q-bio]/Cancer, tDNA, proteomic, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Paper, metabolomic
Abstract

International audience; The identification of diagnostic and prognostic biomarkers from early lesions, measurable in liquid biopsies remains a major challenge, particularly in oncology. Fresh human material of high quality is required for biomarker discovery but is often not available when it is totally required for clinical pathology investigation. Hence, all OMICs studies are done on residual and less clinically relevant biological samples. Here after, we present an innovative, simple, and non-destructive, procedure named EXPEL that uses rapid, pressure-assisted, interstitial fluid extrusion, preserving the specimen for full routine clinical pathology investigation. In the meantime, the technique allows a comprehensive OMICs analysis (proteins, metabolites, miRNAs and DNA). As proof of concept, we have applied EXPEL on freshly collected human colorectal cancer and liver metastases tissues. We demonstrate that the procedure efficiently allows the extraction, within a few minutes, of a wide variety of biomolecules holding diagnostic and prognostic potential while keeping both tissue morphology and antigenicity unaltered. Our method enables, for the first time, both clinicians and scientists to explore identical clinical material regardless of its origin and size, which has a major positive impact on translation to the clinic.

Published
2018

9. Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases

Author

Blomme, Arnaud, primary, Van Simaeys, Gaetan, additional, Doumont, Gilles, additional, Costanza, Brunella, additional, Bellier, Justine, additional, Otaka, Yukihiro, additional, Sherer, Félicie, additional, Lovinfosse, Pierre, additional, Boutry, Sébastien, additional, Palacios, Ana Perez, additional, De Pauw, Edwin, additional, Hirano, Touko, additional, Yokobori, Takehiko, additional, Hustinx, Roland, additional, Bellahcène, Akeila, additional, Delvenne, Philippe, additional, Detry, Olivier, additional, Goldman, Serge, additional, Nishiyama, Masahiko, additional, Castronovo, Vincent, additional, and Turtoi, Andrei, additional

Published
2017
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11. Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats.

Author

Jiang W, Kakizaki T, Fujihara K, Miyata S, Zhang Y, Suto T, Kato D, Saito S, Shibasaki K, Ishizaki Y, Isoda K, Yokoo H, Obinata H, Hirano T, Miyasaka Y, Mashimo T, and Yanagawa Y

Subjects
Animals, Glutamate Decarboxylase metabolism, Rats, Rats, Mutant Strains, Glutamate Decarboxylase deficiency, Palate embryology, Prosencephalon embryology, Retina embryology
Abstract

GABA is a major neurotransmitter in the mammalian central nervous system. Glutamate decarboxylase (GAD) synthesizes GABA from glutamate, and two isoforms of GAD, GAD65, and GAD67, are separately encoded by the Gad2 and Gad1 genes, respectively. The phenotypes differ in severity between GAD single isoform-deficient mice and rats. For example, GAD67 deficiency causes cleft palate and/or omphalocele in mice but not in rats. In this study, to further investigate the functional roles of GAD65 and/or GAD67 and to determine the contribution of these isoforms to GABA synthesis during development, we generated various kinds of GAD isoform(s)-deficient rats and characterized their phenotypes. The age of death was different among Gad mutant rat genotypes. In particular, all Gad1 -/- ; Gad2 -/- rats died at postnatal day 0 and showed little alveolar space in their lungs, suggesting that the cause of their death was respiratory failure. All Gad1 -/- ; Gad2 -/- rats and 18% of Gad1 -/- ; Gad2 +/- rats showed cleft palate. In contrast, none of the Gad mutant rats including Gad1 -/- ; Gad2 -/- rats, showed omphalocele. These results suggest that both rat GAD65 and GAD67 are involved in palate formation, while neither isoform is critical for abdominal wall formation. The GABA content in Gad1 -/- ; Gad2 -/- rat forebrains and retinas at embryonic day 20 was extremely low, indicating that almost all GABA was synthesized from glutamate by GADs in the perinatal period. The present study shows that Gad mutant rats are a good model for further defining the role of GABA during development., (© 2021 Federation of American Societies for Experimental Biology.)

Published
2022
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