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3. Clinical significance of subepithelial growth patterns in non-muscle invasive bladder cancer

Author

Miyake Makito, Hirao Shuya, Mibu Hisakazu, Tanaka Masahiro, Takashima Kenji, Shimada Keiji, and Hirao Kazuya

Subjects
bladder cancer, endophytic growth pattern, prognostic factor, infiltrative pattern, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background We evaluated the clinical significance and prognostic value of histopathological features of bladder cancer, such as subepithelial growth patterns and tumor growth pattern at the invasion front. Methods In total, 130 patients newly diagnosed with non-muscle invasive bladder cancer and underwent transurethral resection between 1998 and 2009 were enrolled. Subepithelial growth patterns consisting of endophytic growth pattern (EGP) and von Brunn's nest involvement (VBNI) were investigated using hematoxylin and eosin-stained slides, and their frequency of occurrence, prognostic value, and correlation with other clinicopathological features was evaluated. Results EGP and VBNI were found in 40 (30.8%) and 5 (3.9%) of the 130 cases, respectively. Of the 26 pT1 tumors, the growth pattern at the invasion front was trabecular in 17 (65.4%) and infiltrative in 9 (34.6%). Although 8 (47.1%) of 17 trabecular tumors coexisted with EGP, no cases with infiltrative tumors had EGP (p = 0.023). VBNI correlated with high tumor grades (p = 0.006) and lymphovascular involvement (p = 0.026). The multivariate Cox proportional hazards analysis revealed that tumor diameter less than 3 cm (p = 0.04) and intravesical bacillus Calmette-Guérin therapy (p = 0.004) were independent favorable prognostic factors for recurrence-free survival, whereas tumor stage was an independent poor prognostic factor for disease progression (p = 0.006). Conclusions Subepithelial growth patterns were not a significant prognostic factor in this study. Additionally, no tumors with an infiltrative growth pattern coexisted with EGP, suggesting that determining the presence of EGP might be helpful for managing non-muscle invasive bladder cancers.

Published
2011
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5. A case of renal cell carcinoma producing alpha-fetoprotein

Author

AOKI, Katsuya, NAKANOU, Isamu, TAKASHIMA, Kenji, HIRAO, Kazuya, HIRAMATSU, Tadashi, FUJIMOTO, Kiyohide, KAGEBAYASHI, Yoriaki, OZONO, Seiichiro, and HIRAO, Yoshihiko

Subjects
494.9, α-Fetoprotein, Renal cell carcinoma
Abstract

69歳男.慢性肝炎の治療で近医に通院中であった.血中α-Fetoprotein(AFP)値が高値を示した為, 腹部超音波断層検査及びCTを施行した.右腎下極に腫瘍を指摘され, 精査加療目的で著者の病院に入院した.画像所見などから右腎細胞癌と診断して根治的右腎摘出術を施行した.病理組織学的所見からAFP産生腎細胞癌と診断した.術後AFP値は漸減し, 術後7週目には正常範囲まで下降した.術後38ヵ月後の現時点において, 画像上は局所再発, 転移を認めず, 肝原発腫瘍や慢性肝炎の増悪も認めていない.AFPの推移と再発・転移に関して外来で経過観察を行っている, Renal cell carcinoma (RCC) producing alpha-fetoprotein (AFP) is a rare condition with only 11 cases reported in Japan to our knowledge. A 69-year-old man was admitted to our hospital for further examination of an incidental right renal tumor. Laboratory tests showed markedly increased serum level of AFP whereas both HBs antigen and anti-HCV antibody were negative. Computed tomography and magnetic resonance imaging imagings showed a right renal tumor but no tumor in liver, testis or lymph node. We performed right radical nephrectomy. Serum level of AFP declined within the normal range 7 weeks after nephrectomy according to its half-life curve. The tumor specimen was composed mainly of granular cells. Immunohistochemical examination of the tumor cells proved the presence of AFP in the cytoplasm. The possibility of AFP as a tumor marker of renal cell carcinoma in this case was presented.

Published
2001

6. 膀胱結石に合併した膀胱扁平上皮癌の1例

Author

Hirata, Naoya, Maruyama, Yoshio, Tanaka, Nobumichi, Hirayama, Aakihide, Samma, Shoji, Ozono, Seiichiro, Hirao, Yoshihiko, Okajima, Eigoro, Hiramatsu, Tadashi, and Hirao, Kazuya

Subjects
Adult, Male, Urinary Bladder Neoplasms/complications/pathology, stomatognathic diseases, Humans, 494.9, urologic and male genital diseases, Urinary Bladder Calculi/complications/pathology, Carcinoma, Squamous Cell/complications/pathology
Abstract

A case of squamous cell carcinoma of the urinary bladder associated with a bladder stone in a 43-year-old man is reported. Because a 1 cm x 1 cm sized mass was found in the right lateral side of the dome at the time of vesicolithotomy, partial cystectomy was performed. The weight of the stone was 285 g and the tumor was histologically diagnosed as squamous cell carcinoma, grade 2, pT2. Radical cystectomy with ileal conduit was sandwiched by a total of 6 cycles of chemotherapy with PVB. Twelve cases of squamous cell carcinoma of the urinary bladder associated with a bladder stone(s) from the Japanese literature are reviewed, and the relationship between bladder stone, leukoplakia and squamous cell carcinoma discussed.

Published
1991

8. A case of penile cavernitis following a penile prosthesis implantation

Author

Kagebayashi, Yoriaki, Hayashi, Yoshiki, Hirao, Kazuya, Tanaka, Nobumichi, Yoneda, Tatuo, and Hirao, Yoshihiko

Subjects
Penile prosthesis, 494.9, Cavernitis
Abstract

A 25-year old man, who had an inferiority of having a small penis and normal potency, underwent intracavernous implantation of hand-made silicone rods by a cosmetic surgeon in order to enlarge his penis. He had pyrexia and swelling of the penis 2 days after the implantation, and penile cavernitis developed. The penile symptoms improved by drainage and strict chemotherapy, and then the silicone rods were removed from his penis. Histopathological findings of the corpus cavernosum showed marked inflammatory and granulomatous changes. The patient lost his potency due to poor blood flow into the cavernous.

Published
1991

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Author

AOKI, Katsuya, NAKANOU, Isamu, TAKASHIMA, Kenji, HIRAO, Kazuya, HIRAMATSU, Tadashi, FUJIMOTO, Kiyohide, KAGEBAYASHI, Yoriaki, OZONO, Seiichiro, HIRAO, Yoshihiko, AOKI, Katsuya, NAKANOU, Isamu, TAKASHIMA, Kenji, HIRAO, Kazuya, HIRAMATSU, Tadashi, FUJIMOTO, Kiyohide, KAGEBAYASHI, Yoriaki, OZONO, Seiichiro, and HIRAO, Yoshihiko

Abstract

Renal cell carcinoma (RCC) producing alpha-fetoprotein (AFP) is a rare condition with only 11 cases reported in Japan to our knowledge. A 69-year-old man was admitted to our hospital for further examination of an incidental right renal tumor. Laboratory tests showed markedly increased serum level of AFP whereas both HBs antigen and anti-HCV antibody were negative. Computed tomography and magnetic resonance imaging imagings showed a right renal tumor but no tumor in liver, testis or lymph node. We performed right radical nephrectomy. Serum level of AFP declined within the normal range 7 weeks after nephrectomy according to its half-life curve. The tumor specimen was composed mainly of granular cells. Immunohistochemical examination of the tumor cells proved the presence of AFP in the cytoplasm. The possibility of AFP as a tumor marker of renal cell carcinoma in this case was presented.

Published
2001

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Author

Kagebayashi, Yoriaki, Hayashi, Yoshiki, Hirao, Kazuya, Tanaka, Nobumichi, Yoneda, Tatuo, Hirao, Yoshihiko, Kagebayashi, Yoriaki, Hayashi, Yoshiki, Hirao, Kazuya, Tanaka, Nobumichi, Yoneda, Tatuo, and Hirao, Yoshihiko

Abstract

A 25-year old man, who had an inferiority of having a small penis and normal potency, underwent intracavernous implantation of hand-made silicone rods by a cosmetic surgeon in order to enlarge his penis. He had pyrexia and swelling of the penis 2 days after the implantation, and penile cavernitis developed. The penile symptoms improved by drainage and strict chemotherapy, and then the silicone rods were removed from his penis. Histopathological findings of the corpus cavernosum showed marked inflammatory and granulomatous changes. The patient lost his potency due to poor blood flow into the cavernous.

Published
1991

17. This title is unavailable for guests, please login to see more information.

Author

Hirata, Naoya, Maruyama, Yoshio, Tanaka, Nobumichi, Hirayama, Aakihide, Samma, Shoji, Ozono, Seiichiro, Hirao, Yoshihiko, Okajima, Eigoro, Hiramatsu, Tadashi, Hirao, Kazuya, Hirata, Naoya, Maruyama, Yoshio, Tanaka, Nobumichi, Hirayama, Aakihide, Samma, Shoji, Ozono, Seiichiro, Hirao, Yoshihiko, Okajima, Eigoro, Hiramatsu, Tadashi, and Hirao, Kazuya

Abstract

A case of squamous cell carcinoma of the urinary bladder associated with a bladder stone in a 43-year-old man is reported. Because a 1 cm x 1 cm sized mass was found in the right lateral side of the dome at the time of vesicolithotomy, partial cystectomy was performed. The weight of the stone was 285 g and the tumor was histologically diagnosed as squamous cell carcinoma, grade 2, pT2. Radical cystectomy with ileal conduit was sandwiched by a total of 6 cycles of chemotherapy with PVB. Twelve cases of squamous cell carcinoma of the urinary bladder associated with a bladder stone(s) from the Japanese literature are reviewed, and the relationship between bladder stone, leukoplakia and squamous cell carcinoma discussed.

Published
1991

18. Experimental Model of Renal Tumors in Polycystic Kidneys: Effects of Long-Term 2-Amino-4,5-Diphenylthiazole Administration in Rats Treated with N-Ethyl-N-Hydroxyethylnitrosamine

Author

Tsumatani, Kenichi, primary, Nakagawa, Yoshinori, additional, Kitahori, Yoshiteru, additional, Konishi, Noboru, additional, Uemura, Hirotsugu, additional, Ozono, Sechiro, additional, Hirao, Yoshihiko, additional, Okajima, Eigoro, additional, Hirao, Kazuya, additional, and Hiasa, Yoshio, additional

Published
1997
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20. 奈良県立医科大学泌尿器科学教室における1978年の臨床統計

Author

Okajima, Eigoro, Hiramatsu, Tadashi, Hirao, Kazuya, Motomiya, Yoshihiro, Ijuin, Masumi, Hijioka, Takashi, Babaya, Katsuhiro, Shiomi, Tsutomu, Kubota, Kazuo, Komada, Sadao, Sasaki, Kenji, Sanma, Shoji, and Suemori, Tsuyoshi

Subjects
494.9, humanities
Abstract

The following tables show statistics on the inpatients, diseases and operations in our department during the period from January to December of 1978.

Published
1981

21. 奈良県立医科大学泌尿器科教室における1977年の臨床統計

Author

Okajima, Eigoro, Hirao, Kazuya, Hiramatsu, Tadashi, Yoshida, Kohjiro, Motomiya, Yoshihiro, Ijuin, Masumi, Hirao, Yoshihiko, Ikuma, Shoichiro, Hijioka, Takashi, Babaya, Katsuhiro, Ohzono, Seiichiro, Tanaka, Masaki, Hashimoto, Masayoshi, Maruyama, Yoshio, and Watanabe, Shuji

Subjects
494.9, humanities
Abstract

The following table show statistics on the inpatients, diseases and operations in our department during the period from January to December of 1977.

Published
1979

22. 奈良県立医科大学泌尿器科学教室における1976年の臨床統計

Author

Okajima, Eigoro, Hirao, Kazuya, Hiramatsu, Tadashi, Motomiya, Yoshihiro, Ijuin, Masumi, Shiomi, Tsutomu, Babaya, Katsuhiro, Hijioka, Takashi, Ohzono, Seiichiro, Tanaka, Masaki, Hashimoto, Masayoshi, Maruyama, Yoshio, Watanabe, Shuji, Kubota, Kazuo, and Sanma, Shoji

Subjects
494.9, humanities
Abstract

The following tables show statistics on inpatients, diseases and operations in our department during the period from January to December of 1976.

Published
1978

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Author

Okajima, Eigoro, Hiramatsu, Tadashi, Hirao, Kazuya, Motomiya, Yoshihiro, Ijuin, Masumi, Hijioka, Takashi, Babaya, Katsuhiro, Shiomi, Tsutomu, Kubota, Kazuo, Komada, Sadao, Sasaki, Kenji, Sanma, Shoji, Suemori, Tsuyoshi, Okajima, Eigoro, Hiramatsu, Tadashi, Hirao, Kazuya, Motomiya, Yoshihiro, Ijuin, Masumi, Hijioka, Takashi, Babaya, Katsuhiro, Shiomi, Tsutomu, Kubota, Kazuo, Komada, Sadao, Sasaki, Kenji, Sanma, Shoji, and Suemori, Tsuyoshi

Abstract

The following tables show statistics on the inpatients, diseases and operations in our department during the period from January to December of 1978.

Published
1981

24. This title is unavailable for guests, please login to see more information.

Author

Hiramatsu, Tadashi, Hirao, Kazuya, Ijuin, Masumi, ohara, Soichi, Shiomi, Tsutomu, Babaya, Katsuhiro, Hijioka, Takashi, Kubota, Kazuo, Komada, Sadao, Sasaki, Kenji, Sanma, Shoji, Suemori, Tsuyoshi, Yoshida, Kohjiro, Watanabe, Shuji, Ikuma, Shoichiro, Matsushima, Susumu, Aoyama, Hideo, Hiramatsu, Tadashi, Hirao, Kazuya, Ijuin, Masumi, ohara, Soichi, Shiomi, Tsutomu, Babaya, Katsuhiro, Hijioka, Takashi, Kubota, Kazuo, Komada, Sadao, Sasaki, Kenji, Sanma, Shoji, Suemori, Tsuyoshi, Yoshida, Kohjiro, Watanabe, Shuji, Ikuma, Shoichiro, Matsushima, Susumu, and Aoyama, Hideo

Abstract

The effect of Pivmecillinam in acute simple cystitis was studied. The results of this study were as follows. 1. Miction pain and urinary frequency were resolved in 96.5% of the patients. 2. Pyuria and bacteriuria were eradicated in 92.2% and 96.2%, respectively. 3. The causative organisms detected were mostly E. coli (76.3%) and these organisms were eradicated in 93.8%. 4. Pivmecillinam was remarkably effective for the resistant strains against AB-PC, cepharexin and nabidixic acid. 5. No noteworthy side effects were observed, except slight gastrointestinal disturbances in 3 cases. Chemical analysis of the peripheral blood demonstrated no abnormal findings after administration of this drug. 6. Pivmecillinam showed a remarkable efficacy against simple acute cystitis (97.3%). The results indicate that pivmecillinam is a useful drug for therapy of simple acute cystitis.

Published
1979

25. This title is unavailable for guests, please login to see more information.

Author

Okajima, Eigoro, Hirao, Kazuya, Hiramatsu, Tadashi, Yoshida, Kohjiro, Motomiya, Yoshihiro, Ijuin, Masumi, Hirao, Yoshihiko, Ikuma, Shoichiro, Hijioka, Takashi, Babaya, Katsuhiro, Ohzono, Seiichiro, Tanaka, Masaki, Hashimoto, Masayoshi, Maruyama, Yoshio, Watanabe, Shuji, Okajima, Eigoro, Hirao, Kazuya, Hiramatsu, Tadashi, Yoshida, Kohjiro, Motomiya, Yoshihiro, Ijuin, Masumi, Hirao, Yoshihiko, Ikuma, Shoichiro, Hijioka, Takashi, Babaya, Katsuhiro, Ohzono, Seiichiro, Tanaka, Masaki, Hashimoto, Masayoshi, Maruyama, Yoshio, and Watanabe, Shuji

Abstract

The following table show statistics on the inpatients, diseases and operations in our department during the period from January to December of 1977.

Published
1979

26. This title is unavailable for guests, please login to see more information.

Author

Okajima, Eigoro, Hirao, Kazuya, Hiramatsu, Tadashi, Motomiya, Yoshihiro, Ijuin, Masumi, Shiomi, Tsutomu, Babaya, Katsuhiro, Hijioka, Takashi, Ohzono, Seiichiro, Tanaka, Masaki, Hashimoto, Masayoshi, Maruyama, Yoshio, Watanabe, Shuji, Kubota, Kazuo, Sanma, Shoji, Okajima, Eigoro, Hirao, Kazuya, Hiramatsu, Tadashi, Motomiya, Yoshihiro, Ijuin, Masumi, Shiomi, Tsutomu, Babaya, Katsuhiro, Hijioka, Takashi, Ohzono, Seiichiro, Tanaka, Masaki, Hashimoto, Masayoshi, Maruyama, Yoshio, Watanabe, Shuji, Kubota, Kazuo, and Sanma, Shoji

Abstract

The following tables show statistics on inpatients, diseases and operations in our department during the period from January to December of 1976.

Published
1978

28. TWO CASES OF CONGENITAL MESOBLASTIC NEPHROMA

Author

Babaya, Katsuhiro, primary, Shiomi, Tsutomu, additional, Hirao, Yoshihiko, additional, Hirao, Kazuya, additional, Hiramatsu, Tadashi, additional, Okajima, Eigoro, additional, Aoyama, Hideo, additional, Kin, Tetsushu, additional, Hashimoto, Kenji, additional, and Ogawa, Hiroshi, additional

Published
1980
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29. Clinical and experimental Studies on cavernous hemangioma of the liver

Author

YOSHIDA, Hideaki, primary, ENOMOTO, Yasuhisa, additional, HIRAO, Kazuya, additional, IMAGAWA, Atsushi, additional, MATSUMURA, Kazutaka, additional, HAYASHI, Yoshiro, additional, OZAWA, Toshihiro, additional, YOSHIKAWA, Takashi, additional, SHIRATORI, Tsuneo, additional, OOISHI, Hajime, additional, HOSOKI, Yasuhiro, additional, and KANI, Toshimi, additional

Published
1979
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33. [Paravesical suture abscess diagnosed 4 years after transvaginal uterectomy].

Author

Miyake M, Takashima K, Hiramatsu T, and Hirao K

Subjects
Female, Humans, Middle Aged, Urinary Bladder surgery, Abscess diagnosis, Granuloma, Foreign-Body diagnosis, Hysterectomy, Vaginal, Postoperative Complications diagnosis, Sutures, Urinary Bladder Diseases diagnosis
Abstract

A 47-year-old woman with previous history of transvaginal uterectomy 4 years before, presented to another hospital complaining of pollakisuria and pain during micturition. She was treated with antibiotics, but symptoms failed to resolve. So she referred to our department for investigations and treatments. On cystoscopy, there was a large mass with edematous mucosa in the anterior wall of bladder. Magnetic resonance image demonstrated an 8 cm irregularly-formed cystic mass which occupied dome of bladder. Resection of the mass including partial cystectomy was performed. This cystic mass contained retained 3 silk sutures surrounded by green color pus. Microscopic examination revealed inflammatory granulations without any malignancy. Because of the previous history, she was diagnosed as paravesical suture abscess due to infected silk materials at transvaginal uterectomy. Paravesical suture abscess is very rare complication of inguinal herniorrhaphy and mimics bladder or urachal neoplasm. In review of previously reported cases, the symotoms were predominantly urological. For avoiding unnecessary examinations and treatments, it is important to consider paravesical suture abscess in cases with histories of inguinal herniorrhaphy or other intra-pelvic operations. To our knowledge, there is no case report of paravesical abscess formation associated with transvaginal uterectomy and the present case is the first one for report.

Published
2006
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34. [Analysis of sports hematuria after running in summer].

Author

Ota M, Ozono S, Ikeda T, Nakanou I, Hirao Y, Watanabe S, Takashima K, and Hirao K

Subjects
Adult, Erythrocyte Count, Female, Flow Cytometry, Humans, Male, Urinalysis, Hematuria etiology, Running physiology
Abstract

Background: The recent sport promotion and healthy boom brought increasing the sport population. Running especially is the most popular activity. Various urinary abnormalities are induced by strenunous exercise. Hematuria has been found after various sports activities and noted as sports hematuria by some studies. We evaluated relation between hematuria and running as the most popular sport in summer., Material and Methods: Urine samples were obtained from 109 healthy volunteers participated in 5 km run, at rest before and immediately after running. We could evaluate 90 of all and investigate counts and morphpology of urinary red cells by microscopic finding of urine sediments and analysis of flowcytometry for urinary cells., Results: Eighty-three subjects had increased counts of urinary red cells after running. Of these, 32 had counts above the normal range, microscopic hematuria (RBC above 3/hpf). In analysis of these 32 had dysmorphic pattern mostly., Conclusion: This study confirms that exercise induces hematuria easily and sports hematuria has a glomerular source chiefly.

Published
2004
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