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2. Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Cheung, A, Chang, T, Cushman, W, Furth, S, Ix, J, Pecoits-Filho, R, Perkovic, V, Sarnak, M, Tobe, S, Tomson, C, Cheung, M, Wheeler, D, Winkelmayer, W, Mann, J, Bakris, G, Damasceno, A, Dwyer, J, Fried, L, Haynes, R, Hirawa, N, Holdaas, H, Ibrahim, H, Ingelfinger, J, Iseki, K, Khwaja, A, Kimmel, P, Kovesdy, C, Ku, E, Lerma, E, Luft, F, Lv, J, Mcfadden, C, Muntner, P, Myers, M, Navaneethan, S, Parati, G, Peixoto, A, Prasad, R, Rahman, M, Rocco, M, Rodrigues, C, Roger, S, Stergiou, G, Tomlinson, L, Tonelli, M, Toto, R, Tsukamoto, Y, Walker, R, Wang, A, Wang, J, Warady, B, Whelton, P, Williamson, J, Cheung A. K., Chang T. I., Cushman W. C., Furth S. L., Ix J. H., Pecoits-Filho R., Perkovic V., Sarnak M. J., Tobe S. W., Tomson C. R. V., Cheung M., Wheeler D. C., Winkelmayer W. C., Mann J. F. E., Bakris G. L., Damasceno A., Dwyer J. P., Fried L. F., Haynes R., Hirawa N., Holdaas H., Ibrahim H. N., Ingelfinger J. R., Iseki K., Khwaja A., Kimmel P. L., Kovesdy C. P., Ku E., Lerma E. V., Luft F. C., Lv J., McFadden C. B., Muntner P., Myers M. G., Navaneethan S. D., Parati G., Peixoto A. J., Prasad R., Rahman M., Rocco M. V., Rodrigues C. I. S., Roger S. D., Stergiou G. S., Tomlinson L. A., Tonelli M., Toto R. D., Tsukamoto Y., Walker R., Wang A. Y. -M., Wang J., Warady B. A., Whelton P. K., Williamson J. D., Cheung, A, Chang, T, Cushman, W, Furth, S, Ix, J, Pecoits-Filho, R, Perkovic, V, Sarnak, M, Tobe, S, Tomson, C, Cheung, M, Wheeler, D, Winkelmayer, W, Mann, J, Bakris, G, Damasceno, A, Dwyer, J, Fried, L, Haynes, R, Hirawa, N, Holdaas, H, Ibrahim, H, Ingelfinger, J, Iseki, K, Khwaja, A, Kimmel, P, Kovesdy, C, Ku, E, Lerma, E, Luft, F, Lv, J, Mcfadden, C, Muntner, P, Myers, M, Navaneethan, S, Parati, G, Peixoto, A, Prasad, R, Rahman, M, Rocco, M, Rodrigues, C, Roger, S, Stergiou, G, Tomlinson, L, Tonelli, M, Toto, R, Tsukamoto, Y, Walker, R, Wang, A, Wang, J, Warady, B, Whelton, P, Williamson, J, Cheung A. K., Chang T. I., Cushman W. C., Furth S. L., Ix J. H., Pecoits-Filho R., Perkovic V., Sarnak M. J., Tobe S. W., Tomson C. R. V., Cheung M., Wheeler D. C., Winkelmayer W. C., Mann J. F. E., Bakris G. L., Damasceno A., Dwyer J. P., Fried L. F., Haynes R., Hirawa N., Holdaas H., Ibrahim H. N., Ingelfinger J. R., Iseki K., Khwaja A., Kimmel P. L., Kovesdy C. P., Ku E., Lerma E. V., Luft F. C., Lv J., McFadden C. B., Muntner P., Myers M. G., Navaneethan S. D., Parati G., Peixoto A. J., Prasad R., Rahman M., Rocco M. V., Rodrigues C. I. S., Roger S. D., Stergiou G. S., Tomlinson L. A., Tonelli M., Toto R. D., Tsukamoto Y., Walker R., Wang A. Y. -M., Wang J., Warady B. A., Whelton P. K., and Williamson J. D.

Abstract

In September 2017, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference titled Blood Pressure in Chronic Kidney Disease (CKD). The purpose of the meeting was to consider which recommendations from the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD should be reevaluated based on new evidence from clinical trials. Participants included a multidisciplinary panel of clinical and scientific experts. Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients. Consistent with the 2012 Guideline, the conference did not address BP management in patients on maintenance dialysis.

Published
2019

9. Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension

Author

Tabara, Y, Kohara, K, Kita, Y, Hirawa, N, Katsuya, T, Ohkubo, T, Hiura, Y, Tajima, A, Morisaki, T, Miyata, T, Nakayama, T, Takashima, N, Nakura, J, Kawamoto, R, Takahashi, N, Hata, A, Soma, M, Imai, Y, Kokubo, Y, Okamura, T, Tomoike, H, Iwai, N, Ogihara, T, Inoue, I, Tokunaga, K, Johnson, T, Caulfield, M, Munroe, P, Global Blood Pressure Genetics Consortium, Umemura, S, Ueshima, H, Collaborators: Newton Cheh C, Miki T., Gateva, V, Tobin, Md, Bochud, M, Coin, L, Najjar, Ss, Zhao, Jh, Heath, Sc, Eyheramendy, S, Papadakis, K, Voight, Bf, Scott, Lj, Zhang, F, Farrall, M, Tanaka, T, Wallace, C, Chambers, Jc, Khaw, Kt, Nilsson, P, van der Harst, P, Polidoro, Silvia, Grobbee, De, Onland Moret NC, Bots, Ml, Wain, Lv, Elliott, Ks, Teumer, A, Luan, J, Lucas, G, Kuusisto, J, Burton, Pr, Hadley, D, Mcardle, Wl, Brown, M, Dominiczak, A, Newhouse, Sj, Samani, Nj, Webster, J, Zeggini, E, Beckmann, Js, Bergmann, S, Lim, N, Song, K, Vollenweider, P, Waeber, G, Waterworth, Dm, Yuan, X, Groop, L, Orho Melander, M, Allione, A, DI GREGORIO, Alessandra, Guarrera, Simonetta, Panico, S, Ricceri, Fulvio, Romanazzi, Valeria, Sacerdote, Carlotta, Vineis, Paolo, Barroso, I, Sandhu, Ms, Luben, Rn, Crawford, Gj, Jousilahti, P, Perola, M, Boehnke, M, Bonnycastle, Ll, Collins, Fs, Jackson, Au, Mohlke, Kl, Stringham, Hm, Valle, Tt, Willer, Cj, Bergman, Rn, Morken, Ma, Döring, A, Gieger, C, Illig, T, Meitinger, T, Org, E, Pfeufer, A, Wichmann, He, Kathiresan, S, Marrugat, J, O'Donnell, Cj, Schwartz, Sm, Siscovick, Ds, Subirana, I, Freimer, Nb, Hartikainen, Al, Mccarthy, Mi, O'Reilly, Pf, Peltonen, L, Pouta, A, de Jong PE, Snieder, H, van Gilst WH, Clarke, R, Goel, A, Hamsten, A, Peden, Jf, Seedorf, U, Syvänen, Ac, Tognoni, G, Lakatta, Eg, Sanna, S, Scheet, P, Schlessinger, D, Scuteri, A, Dörr, M, Ernst, F, Felix, Sb, Homuth, G, Lorbeer, R, Reffelmann, T, Rettig, R, Völker, U, Galan, P, Gut, Ig, Hercberg, S, Lathrop, Gm, Zeleneka, D, Deloukas, P, Soranzo, N, Williams, Fm, Zhai, G, Salomaa, V, Laakso, M, Elosua, R, Forouhi, Ng, Völzke, H, Uiterwaal, Cs, van der Schouw YT, Numans, Me, Matullo, Giuseppe, Navis, G, Berglund, G, Bingham, Sa, Kooner, Js, Connell, Jm, Bandinelli, S, Ferrucci, L, Watkins, H, Spector, Td, Tuomilehto, J, Altshuler, D, Strachan, Dp, Laan, M, Meneton, P, Wareham, Nj, Uda, M, Jarvelin, Mr, Mooser, V, Melander, O, Loos, Rj, Elliott, P, Abecasis, Gr, and Munroe, Pb

Subjects
medicine.medical_specialty, hypertension, Genotype, Single-nucleotide polymorphism, ATP2B1, Biology, Lower risk, Polymorphism, Single Nucleotide, Article, Plasma Membrane Calcium-Transporting ATPases, Asian People, Gene Frequency, Polymorphism (computer science), Internal medicine, genetic variation, Millenium Genome Project, Global BPgen, Genetic variation, Odds Ratio, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Allele, Alleles, Genetic association, Genetics, Analysis of Variance, Odds ratio, Blood pressure, Haplotypes, Case-Control Studies, Hypertension, Millennium genome project, Global Bpgen, Regression Analysis, Genome-Wide Association Study
Abstract

Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association with hypertension in Japanese individuals. In this study we extend our previous findings by analyzing a large sample of Japanese individuals (n=14 105) for the most associated SNPs. We also conducted replication analyses in Japanese of susceptibility loci for hypertension identified recently from genome-wide association studies of European ancestries. Association analysis revealed significant association of the ATP2B1 rs2070759 polymorphism with hypertension ( P =5.3×10 −5 ; allelic odds ratio: 1.17 [95% CI: 1.09 to 1.26]). Additional SNPs in ATP2B1 were subsequently genotyped, and the most significant association was with rs11105378 (odds ratio: 1.31 [95% CI: 1.21 to 1.42]; P =4.1×10 −11 ). Association of rs11105378 with hypertension was cross-validated by replication analysis with the Global Blood Pressure Genetics consortium data set (odds ratio: 1.13 [95% CI: 1.05 to 1.21]; P =5.9×10 −4 ). Mean adjusted systolic blood pressure was highly significantly associated with the same SNP in a meta-analysis with individuals of European descent ( P =1.4×10 −18 ). ATP2B1 mRNA expression levels in umbilical artery smooth muscle cells were found to be significantly different among rs11105378 genotypes. Seven SNPs discovered in published genome-wide association studies were also genotyped in the Japanese population. In the combined analysis with replicated 3 genes, FGF5 rs1458038, CYP17A1 , rs1004467, and CSK rs1378942, odds ratio of the highest risk group was 2.27 (95% CI: 1.65 to 3.12; P =4.6×10 −7 ) compared with the lower risk group. In summary, this study confirmed common genetic variation in ATP2B1 , as well as FGF5 , CYP17A1 , and CSK , to be associated with blood pressure levels and risk of hypertension.

Published
2010
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10. Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium GenomeProject

Author

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P, Newton Cheh C, Gateva V, Tobin MD, Bochud M, Coin L, Najjar S, Zhao JH, Heath SC, Eyheramendy S, Wallace C, Chambers JC, Khaw KT, Polidoro S, Grobbee DE, Onland Moret NC, Allione A, Di Gregorio A, Guarrera S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder P, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Galan P, Gut IV, Hercberg S, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bandinelli S, Ferrucci L, Watkins H, Tuomilehto J, Altshuler D, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RFJ, Elliott P, Abecasis GR, Munroe PB, Umemura S, Ueshima H, Miki T., PANICO, SALVATORE, Tabara, Y, Kohara, K, Kita, Y, Hirawa, N, Katsuya, T, Ohkubo, T, Hiura, Y, Tajima, A, Morisaki, T, Miyata, T, Nakayama, T, Takashima, N, Nakura, J, Kawamoto, R, Takahashi, N, Hata, A, Soma, M, Imai, Y, Kokubo, Y, Okamura, T, Tomoike, H, Iwai, N, Ogihara, T, Inoue, I, Tokunaga, K, Johnson, T, Caulfield, M, Munroe, P, Newton Cheh, C, Gateva, V, Tobin, Md, Bochud, M, Coin, L, Najjar, S, Zhao, Jh, Heath, Sc, Eyheramendy, S, Wallace, C, Chambers, Jc, Khaw, Kt, Polidoro, S, Grobbee, De, Onland Moret, Nc, Allione, A, Di Gregorio, A, Guarrera, S, Panico, Salvatore, Ricceri, F, Romanazzi, V, Sacerdote, C, Vineis, P, Barroso, I, O'Reilly, Pf, Peltonen, L, Pouta, A, de Jong, Pe, Snieder, P, Tognoni, G, Lakatta, Eg, Sanna, S, Scheet, P, Schlessinger, D, Scuteri, A, Galan, P, Gut, Iv, Hercberg, S, van der Schouw, Yt, Numans, Me, Matullo, G, Navis, G, Berglund, G, Bandinelli, S, Ferrucci, L, Watkins, H, Tuomilehto, J, Altshuler, D, Wareham, Nj, Uda, M, Jarvelin, Mr, Mooser, V, Melander, O, Loos, Rfj, Elliott, P, Abecasis, Gr, Munroe, Pb, Umemura, S, Ueshima, H, and Miki, T.

Published
2010

14. PP.07.14

Author

Yasuda, G., primary, Saka, S., additional, Yamamoto, Y., additional, and Hirawa, N., additional

Published
2015
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16. DIALYSIS ANAEMIA

Author

Locatelli, F., primary, Choukroun, G., additional, Fliser, D., additional, Moecks, J., additional, Wiggenhauser, A., additional, Gupta, A., additional, Swinkels, D. W., additional, Lin, V., additional, Guss, C., additional, Pratt, R., additional, Carrilho, P., additional, Martins, A. R., additional, Alves, M., additional, Mateus, A., additional, Gusmao, L., additional, Parreira, L., additional, Assuncao, J., additional, Rodrigues, I., additional, Stamopoulos, D., additional, Mpakirtzi, N., additional, Afentakis, N., additional, Grapsa, E., additional, Zitt, E., additional, Sturm, G., additional, Kronenberg, F., additional, Neyer, U., additional, Knoll, F., additional, Lhotta, K., additional, Weiss, G., additional, Robinson, B. M., additional, Larkina, M., additional, Bieber, B., additional, Kleophas, W., additional, Li, Y., additional, Locatelli, F., additional, McCullough, K., additional, Nolen, J. G., additional, Port, F. K., additional, Pisoni, R. L., additional, Kalicki, R. M., additional, Uehlinger, D. E., additional, Ogawa, C., additional, Kanda, F., additional, Tomosugi, N., additional, Maeda, T., additional, Kuji, T., additional, Fujikawa, T., additional, Shino, M., additional, Shibata, K., additional, Kaneda, T., additional, Nishihara, M., additional, Satta, H., additional, Kawata, S.-I., additional, Koguchi, N., additional, Tamura, K., additional, Hirawa, N., additional, Toya, Y., additional, Umemura, S., additional, Chanliau, J., additional, Martin, H., additional, Stamatelou, K., additional, Gonzalez-Tabares, L., additional, Manamley, N., additional, Farouk, M., additional, Addison, J., additional, Donck, J., additional, Schneider, A., additional, Gutjahr-Lengsfeld, L., additional, Ritz, E., additional, Scharnagl, H., additional, Gelbrich, G., additional, Pilz, S., additional, Macdougall, I. C., additional, Wanner, C., additional, Drechsler, C., additional, Kuntsevich, V., additional, Charen, E., additional, Kobena, D., additional, Sheth, N., additional, Siktel, H., additional, Levin, N. W., additional, Winchester, J. F., additional, Kotanko, P., additional, Kaysen, G., additional, Kuragano, T., additional, Kida, A., additional, Yahiro, M., additional, Nanami, M., additional, Nagasawa, Y., additional, Hasuike, Y., additional, Nakanishi, T., additional, Dimitratou, V., additional, Griveas, I., additional, Lianos, E., additional, Sasaki, Y., additional, Yamazaki, S., additional, Fujita, K., additional, Kurasawa, M., additional, Yorozu, K., additional, Shimonaka, Y., additional, Suzuki, N., additional, Yamamoto, M., additional, Zwiech, R., additional, Szczepa ska, J., additional, Bruzda-Zwiech, A., additional, Rao, A., additional, Gilg, J., additional, Caskey, F., additional, Kirkpantur, A., additional, Balci, M. M., additional, Turkvatan, A., additional, Afsar, B., additional, Alkis, M., additional, Mandiroglu, F., additional, Kim, Y. O., additional, Yoon, S. A., additional, Kim, Y. S., additional, Choi, S. J., additional, Min, J. W., additional, Cheong, M. A., additional, Oue, M., additional, Yamamoto, K., additional, Kimura, T., additional, Fukao, W., additional, Kaibe, S., additional, Djuric, P. S., additional, Ikonomovski, J., additional, Tosic, J., additional, Jankovic, A., additional, Majster, Z., additional, Stankovic Popovic, V., additional, Dimkovic, N., additional, Aicardi Spalloni, V., additional, Del Vecchio, L., additional, Longhi, S., additional, Violo, L., additional, La Milia, V., additional, Pontoriero, G., additional, Macdougall, I., additional, Rumjon, A., additional, Mangahis, E., additional, Goldstein, L., additional, Ryzlewicz, T., additional, Becker, F., additional, Kilgallon, W., additional, Fukasawa, M., additional, Otake, Y., additional, Yamagishi, T., additional, Kamiyama, M., additional, Kobayashi, H., additional, Takeda, M., additional, Toida, T., additional, Sato, Y., additional, and Fujimoto, S., additional

Published
2014
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17. HYPERTENSION: EXPERIMENTAL

Author

Yasuda, G., primary, Kinguchi, S., additional, Katsumata, M., additional, Hirawa, N., additional, Shibata, K., additional, Van Roeyen, C. R. C., additional, Drescher, A., additional, Hess, K., additional, Boor, P., additional, Martin, I. V., additional, Zok, S., additional, Braun, G., additional, Kuppe, C., additional, Liehn, E., additional, Weiskirchen, R., additional, Eriksson, U., additional, Gross, O., additional, Floege, J., additional, Eitner, F., additional, Ostendorf, T., additional, Mose, F. H., additional, Jensen, J. M., additional, Therwani, S., additional, Mortensen, J., additional, Hansen, A. B., additional, Bech, J. N., additional, Pedersen, E. B., additional, Vink, E. E., additional, De Boer, A., additional, Hoogduin, J. M., additional, Leiner, T., additional, Bots, M. L., additional, Blankestijn, P. J., additional, Silva Sousa, H., additional, Branco, P., additional, Dores, H., additional, Carvalho, M. S., additional, Goncalves, P., additional, Almeida, M. S., additional, Andrade, M. J., additional, Pereira, M., additional, Gaspar, M. A., additional, Mendes, M., additional, and Barata, J. D., additional

Published
2014
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19. Hypertension - experimental models

Author

Clotet, S., primary, Soler, M. J., additional, Rebull, M., additional, Pascual, J., additional, Riera, M., additional, Kucher, A. G., additional, Parastaeva, M. M., additional, Beresneva, O. N., additional, Ivanova, G. T., additional, Zaraysky, M. I., additional, Artemeva, A. V., additional, Kaukov, I. G., additional, Smirnov, A. V., additional, Roszkowska-Chojecka, M., additional, Walkowska, A., additional, Gawrys, O., additional, Olszynski, K., additional, Kompanowska-Jezierska, E., additional, Baranowska, I., additional, Kompanowska-Jezierska, E. M., additional, Roszkowska-Chojecka, M. M., additional, Dobrowolski, L., additional, Badzynska, B., additional, Olszynski, K. H., additional, Lipkowski, A. W., additional, Sadowski, J., additional, Kobayashi, Y., additional, Hirawa, N., additional, Okuyama, Y., additional, Fujita, M., additional, Fujiwara, A., additional, Saka, S., additional, Yatsu, K., additional, Toya, Y., additional, Yasuda, G., additional, Umemura, S., additional, Oliveira-Sales, E. B., additional, Maquigussa, E., additional, Semedo, P., additional, Pereira, L. G., additional, Camara, N. O. S., additional, Bergamaschi, C. T., additional, Campos, R. R., additional, Boim, M. A., additional, Potenza, M. A., additional, Sirolli, V., additional, Addabbo, F., additional, Di Pietro, N., additional, Amoroso, L., additional, Pipino, C., additional, Pandolfi, A., additional, Montagnani, M., additional, Bonomini, M., additional, Quiroz, Y. J., additional, Rivero, M., additional, Yaguas, K., additional, Moran, L., additional, Rodriguez-Iturbe, B., additional, Lee, J., additional, Heo, N. J., additional, Kim, S., additional, Joo, K. W., additional, Han, J. S., additional, Rapp, W., additional, Raab, S., additional, Sprecher, U., additional, Funk, J., additional, Apfel, C. M., additional, Conde-Knape, K., additional, Qin, Y., additional, Mou, L., additional, Li, X., additional, Ilatovskaya, M. E., additional, Andreev-Andrievsky, A. A., additional, Pozdnev, V. F., additional, Iliyn, A. V., additional, Medvedeva, N. A., additional, Malyszko, J., additional, Koc-Zorawska, E., additional, Zbroch, E., additional, Malyszko, J. S., additional, Zorawski, M., additional, Mysliwiec, M., additional, Wakui, H., additional, Tamura, K., additional, Masuda, S.-i., additional, Tsurumi-Ikeya, Y., additional, Kanaoka, T., additional, Fujikawa, T., additional, Suzuki, S., additional, Yabana, M., additional, Iimuro, S., additional, Imai, E., additional, Matsuo, S., additional, Watanabe, T., additional, Nitta, K., additional, Akizawa, T., additional, Makino, H., additional, Ohashi, Y., additional, and Hishida, A., additional

Published
2013
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20. High-Resolution Mapping for Essential Hypertension Using Microsatellite Markers

Author

Yatsu, K., Mizuki, N., Hirawa, N., Oka, A., Itoh, N., Yamane, T., Ogawa, M., Shiwa, T., Tabara, Y., Ohno, S., Soma, M., Hata, A., Nakao, K., Ueshima, H., Ogihara, T., Tomoike, H., Miki, T., Kimura, A., Mano, S., Kulski, J.K., Umemura, S., Inoko, H., Yatsu, K., Mizuki, N., Hirawa, N., Oka, A., Itoh, N., Yamane, T., Ogawa, M., Shiwa, T., Tabara, Y., Ohno, S., Soma, M., Hata, A., Nakao, K., Ueshima, H., Ogihara, T., Tomoike, H., Miki, T., Kimura, A., Mano, S., Kulski, J.K., Umemura, S., and Inoko, H.

Abstract

During the past decade, considerable efforts and resources have been devoted to elucidating the multiple genetic and environmental determinants responsible for hypertension and its associated cardiovascular diseases. The success of positional cloning, fine mapping, and linkage analysis based on whole-genome screening, however, has been limited in identifying multiple genetic determinants affecting diseases, suggesting that new research strategies for genome-wide typing may be helpful. Disease association (case-control) studies using microsatellite markers, distributed every 150 kb across the human genome, may have some advantages over linkage, candidate, and single nucleotide polymorphism typing methods in terms of statistical power and linkage disequilibrium for finding genomic regions harboring candidate disease genes, although it is not proven. We have carried out genome-wide mapping using 18 977 microsatellite markers in a Japanese population composed of 385 hypertensive patients and 385 normotensive control subjects. Pooled sample analysis was conducted in a 3-stage genomic screen of 3 independent case-control populations, and 54 markers were extracted from the original 18 977 microsatellite markers. As a final step, each single positive marker was confirmed by individual typing, and only 19 markers passed this test. We identified 19 allelic loci that were significantly different between the cases of essential hypertension and the controls.

Published
2007

22. MICE LACKING ATP2B1 GENE, THE NEW HYPERTENSION CANDIDATE GENE, IN VASCULAR SMOOTH MUSCLE SHOWS BLOOD PRESSURE ELEVATION

Author

Kobayashi, Y., primary, Hirawa, N., additional, Fujita, M., additional, Miyazaki, N., additional, Fujiwara, A., additional, Yamamoto, Y., additional, Yoshida, S., additional, Saka, S., additional, Wakui, H., additional, Yatsu, K., additional, Toya, Y., additional, Yasuda, G., additional, Ueshima, H., additional, Miki, T., additional, and Umemura, S., additional

Published
2011
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25. Reply

Author

Kobayashi, M., primary, Hirawa, N., additional, and Umemura, S., additional

Published
2009
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27. Association Between Fatty Acid Binding Protein 3 Gene Variants and Essential Hypertension in Humans

Author

Ueno, T., primary, Soma, M., additional, Tabara, Y., additional, Tokunaga, K., additional, Tahira, K., additional, Fukuda, N., additional, Matsumoto, K., additional, Nakayama, T., additional, Katsuya, T., additional, Ogihara, T., additional, Makita, Y., additional, Hata, A., additional, Yamada, M., additional, Takahashi, N., additional, Hirawa, N., additional, Umemura, S., additional, and Miki, T., additional

Published
2008
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32. TROGLITAZONE TREATMENT IMPROVES BLOOD PRESSURE, RENAL INJURY AND URINARY EXCRETIONS OF UPOCAUN-TYPE PROSTAGLANDIN D SYNTHASE IN OLETF RATS

Author

Hirawa, N, primary, Uehara, Y, additional, Kawabata, Y, additional, Ogawa, M, additional, Taguchi, R, additional, Negoro, H, additional, Eguchi, N, additional, Nagata, N, additional, Tsuchida, T, additional, Seiki, K, additional, Satoh, N, additional, Endoh, T, additional, Matsushita, K, additional, Tamura, K, additional, Yatsu, K, additional, Kihara, M, additional, Toya, Y, additional, Urade, Y, additional, and Umemura, S, additional

Published
2004
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33. THE ROLE OF TISSUE KALLIKREIN GENE POLYMORPHISMS IN ESSENTIAL HYPERTENSION

Author

Hirawa, N, primary, Ishigami, T, additional, Ogawa, M, additional, Yatsu, K, additional, Okano, Y, additional, Sakai, S, additional, Ono, S, additional, Tsurumi, Y, additional, Endoh, T, additional, Matsushita, K, additional, Tamura, K, additional, Kihara, M, additional, Toya, Y, additional, Yasuda, G, additional, and Umemura, S, additional

Published
2004
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