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2. Serum mature and furin-cleaved proprotein convertase subtilisin/kexin type 9 levels and their association with cardiovascular events in statin-treated patients with cardiovascular disease

Author

Hibi, Kiyoshi, Gohbara, Masaomi, Uemura, Kohei, Iwahashi, Noriaki, Okada, Kozo, Iwata, Hiroshi, Fukumoto, Yoshihiro, Hiro, Takafumi, Ozaki, Yukio, Iimuro, Satoshi, Sakuma, Ichiro, Hokimoto, Seiji, Miyauchi, Katsumi, Matsuyama, Yutaka, Nakagawa, Yoshihisa, Ogawa, Hisao, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Kimura, Takeshi, Matsuzaki, Masunori, Kimura, Kazuo, and Nagai, Ryozo

Published
2024
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3. Differential prediction of high-sensitivity cardiac troponin-I, but not N-terminal pro-brain natriuretic peptide, in different pitavastatin doses on cardiovascular events in stable coronary artery disease

Author

Mitsutake, Yoshiaki, Ishii, Junnichi, Fukumoto, Yoshihiro, Ito, Sohei, Kashiwabara, Kosuke, Uemura, Kouhei, Matsuyama, Yutaka, Sugiyama, Yoichi, Ozaki, Yukio, Iimuro, Satoshi, Iwata, Hiroshi, Sakuma, Ichiro, Nakagawa, Yoshihisa, Hibi, Kiyoshi, Hiro, Takafumi, Hokimoto, Seiji, Miyauchi, Katsumi, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Kimura, Takeshi, Matsuzaki, Masunori, and Nagai, Ryozo

Published
2023
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4. Plasma ANGPTL8 Levels and Risk for Secondary Cardiovascular Events in Japanese Patients With Stable Coronary Artery Disease Receiving Statin Therapy

Author

Morinaga, Jun, Kashiwabara, Kosuke, Torigoe, Daisuke, Okadome, Yusuke, Aizawa, Kenichi, Uemura, Kohei, Kurashima, Ai, Matsunaga, Eiji, Fukami, Hirotaka, Horiguchi, Haruki, Sato, Michio, Sugizaki, Taichi, Miyata, Keishi, Kadomatsu, Tsuyoshi, Mukoyama, Masashi, Miyauchi, Katsumi, Hokimoto, Seiji, Fukumoto, Yoshihiro, Hiro, Takafumi, Hibi, Kiyoshi, Nakagawa, Yoshihisa, Sakuma, Ichiro, Ozaki, Yukio, Iwata, Hiroshi, Iimuro, Satoshi, Daida, Hiroyuki, Shimokawa, Hiroaki, Kimura, Takeshi, Matsuzaki, Masunori, Saito, Yasushi, Matsuyama, Yutaka, Nagai, Ryozo, and Oike, Yuichi

Published
2023
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5. Rivaroxaban Monotherapy in Patients With Atrial Fibrillation After Coronary Stenting: Insights From the AFIRE Trial

Author

Yasuda, Satoshi, Ogawa, Hisao, Kimura, Kazuo, Hagiwara, Nobuhisa, Hirayama, Atsushi, Nakamura, Masato, Miyauchi, Katsumi, Ako, Junya, Akao, Masaharu, Kaikita, Koichi, Matoba, Tetsuya, Koretsune, Yukihiro, Hiro, Takafumi, Sumiyoshi, Tetsuya, Kimura, Kazumi, Hashimoto, Yoichiro, Hirano, Teruyuki, Daida, Hiroyuki, Okada, Yasushi, Yamazaki, Tsutomu, Matsui, Kunihiko, Nakamura, A., Tamiya, E., Yamamoto, T., Suetake, S., Noguchi, T., Nakamura, S., Matsumura, A., Kojima, J., Suwa, S., Yamaguchi, H., Kaikita, K., Yasu, T., Nakajima, A., Yamada, T., Arai, H., Hata, Y., Sakanashi, T., Tateishi, H., Nakayama, T., Nozaki, Y., Akao, M., Okumura, Y., Tokue, M., Kuroki, N., Maruyama, Y., Matoba, T., Hagiwara, N., Suzuki, H., Nishida, Y., Ajioka, M., Yumoto, K., Shimizu, S., Aoyama, T., Shimomura, H., Takeda, T., Oshiro, K., Sugishita, N., Shibata, Y., Otonari, T., Kihara, H., Ogawa, H., Ohno, A., Hazama, M., Shimizu, M., Tsukahara, K., Haruta, S., Wakeyama, T., Haruna, T., Ito, M., Fujii, K., Atsuchi, N., Sata, M., Kimura, K., Hasebe, N., Kobayasi, Y., Ohsato, K., Hironaga, K., Naganuma, Y., Anzaki, K., Oiwa, K., Okazaki, S., Nakagawa, Y., Tokuhiro, K., Tanaka, K., Momose, T., Fukushima, Y., Kametani, R., Kawamitsu, K., Saito, Y., Akashi, S., Kumagai, K., Eshima, K., Tobaru, T., Seo, T., Okuhara, K., Kozuma, K., Ikari, Y., Takahashi, T., Michishita, I., Fujikura, H., Momomura, S., Yamamoto, Y., Otomo, K., Matsubara, T., Tashiro, H., Inoue, T., Ishihara, M., Shiojima, I., Tachibana, E., Ako, J., Sumii, K., Yamamoto, N., Ohmura, N., Nakamura, T., Morita, Y., Takahashi, N., Watanabe, K., Fujinaga, H., Maruyama, M., Oka, T., Shirayama, T., Amano, T., Fukui, K., Ando, K., Oshima, S., Kagiyama, S., Teragawa, H., Yuge, M., Ono, S., Koga, T., Fujiu, K., Kuwabara, M., Ohya, Y., Yumoto, Y., Kuji, N., Ikemura, M., Kario, K., Chatani, K., Sato, K., Miyagi, H., Murakami, M., Saito, K., Hoshiga, M., Sato, S., Kubo, N., Sakamoto, Y., Ashida, K., Sakamoto, H., Murasaki, S., Uehara, H., Akasaka, T., Ooba, Y., Nakahara, S., Hanaoka, Y., Nishimiya, T., Tsunoda, R., Onuma, Y., Higuchi, S., Tani, A., Wada, A., Kato, M., Obata, H., Higuchi, Y., Endo, T., Katou, R., Matsunaga, T., Matsuoka, T., Noguchi, H., Usui, M., Hayashi, T., Otsuji, Y., Osaki, T., Zaizen, H., Yoshihara, H., Kadota, K., Hirose, T., Miyazawa, T., Mori, A., Takano, M., Shimizu, W., Wake, M., Oriso, S., Yoshiyama, M., Kakinoki, S., Nishioka, T., Ozaki, T., Nomoto, K., Seki, K., Kawai, K., Ozaki, Y., Miura, S., Kawasaki, M., Funada, R., Dote, K., Nagano, T., Okamoto, S., Kubo, T., Murozono, Y., Owada, T., Doke, T., Matsumura, T., Horiuchi, M., Takaishi, A., Yamamoto, M., Nakashima, H., Munemasa, M., Sakata, Y., Inoue, N., Ota, T., Hamano, Y., Abe, N., Tsubokura, T., Goto, M., Kubota, I., Yano, M., Umetani, K., Date, T., Morimoto, H., Noda, T., Goto, S., Hibi, K., Nakano, A., Hiramitsu, S., Kihara, Y., Sugi, M., Shiba, N., Izumi, D., Sato, T., Tayama, S., Matsui, T., Suzuki, A., Ajiki, K., Oishi, M., Kiryu, M., Ko, T., Ando, H., Miyazaki, S., Kinugawa, T., Otake, H., Kitaoka, H., Hirata, Y., Honda, S., Manita, M., Ishii, Y., Oka, H., Nanba, Y., Nishino, M., Sakamoto, T., Saito, T., Sakai, H., Ichikawa, M., Namiuchi, S., Inoue, K., Komiyama, N., Akashi, Y., Nakamura, Y., Komaru, T., Hosokawa, T., Chikamori, T., Tanaka, H., Arasaki, O., Aonuma, K., Wakasa, Y., Yoshizawa, T., Sugano, T., Yokota, N., Kakutani, A., Suzuki, T., Abe, Y., Kataoka, T., Okayama, H., Yokoi, H., Chin, K., Hasegawa, K., Tomita, H., Honzyo, H., Kawai, H., Yamamoto, K., Morino, Y., Tsujiyama, S., Hamasaki, S., Niijima, Y., Mizuno, Y., Maki, A., Tanabe, K., Murohara, T., Naomi, S., Arikawa, M., Kato, T., Matsumoto, N., Minamino, T., Sairenji, H., Miyamoto, N., Ito, H., Matsuura, Y., Hata, S., Nakatsu, Y., Onodera, T., Yoshimura, M., Amano, H., Tokutake, E., Kasao, M., Moriguchi, M., Tsuji, M., Yamamoto, H., Yanbe, Y., Iwasawa, T., Suzuki, M., and Mori, H.

Published
2021
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6. Relation of renal function to mid-term prognosis of stable angina patients with high- or low-dose pitavastatin treatment: REAL-CAD substudy

Author

Abe, Mitsuru, Ozaki, Yukio, Takahashi, Hiroshi, Ishii, Mitsuru, Masunaga, Nobutoyo, Ismail, Tevfik F., Iimuro, Satoshi, Fujita, Retsu, Iwata, Hiroshi, Sakuma, Ichiro, Nakagawa, Yoshihisa, Hibi, Kiyoshi, Hiro, Takafumi, Fukumoto, Yoshihiro, Hokimoto, Seiji, Miyauchi, Katsumi, Ogawa, Hisao, Daida, Hiroyuki, Shimokawa, Hiroaki, Saito, Yasushi, Matsuzaki, Masunori, Akao, Masaharu, Kimura, Takeshi, and Nagai, Ryozo

Published
2021
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12. Effect of drug-coated balloon angioplasty on in-stent restenotic coronary lesions analyzed with optical coherence tomography and serial coronary artery angioscopy

Author

Akutsu, Naotaka, Ogaku, Akihito, Koyama, Yutaka, Fujito, Hidesato, Ebuchi, Yasunari, Migita, Suguru, Morikawa, Tomoyuki, Tamaki, Takehiro, Mineki, Takashi, Kougo, Takaaki, Kojima, Keisuke, Iida, Korehito, Murata, Nobuhiro, Nishida, Toshihiko, Oshima, Toru, Sudo, Mitsumasa, Kitano, Daisuke, Haruta, Hironori, Fukamachi, Daisuke, Takayama, Tadateru, Hiro, Takafumi, Hirayama, Atsushi, and Okumura, Yasuo

Published
2019
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13. High shear stress on the coronary arterial wall is related to computed tomography-derived high-risk plaque: a three-dimensional computed tomography and color-coded tissue-characterizing intravascular ultrasonography study

Author

Murata, Nobuhiro, Hiro, Takafumi, Takayama, Tadateru, Migita, Suguru, Morikawa, Tomoyuki, Tamaki, Takehiro, Mineki, Takashi, Kojima, Keisuke, Akutsu, Naotaka, Sudo, Mitsumasa, Kitano, Daisuke, Fukamachi, Daisuke, Hirayama, Atsushi, and Okumura, Yasuo

Published
2019
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19. Angle dependence of intravascular ultrasound imaging and its feasibility in tissue characterization of human atherosclerotic tissue

Author

Hiro, Takafumi, Leung, Cyril Y, Karimi, Houshang, Farvid, Ali R, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Biomedical Imaging, Atherosclerosis, Cardiovascular, Adipose Tissue, Analysis of Variance, Anatomy, Cross-Sectional, Arteriosclerosis, Cholesterol, Collagen, Connective Tissue, Feasibility Studies, Fibrosis, Fixatives, Foam Cells, Formaldehyde, Humans, Iliac Artery, Image Processing, Computer-Assisted, Lipids, Regression Analysis, Scattering, Radiation, Surface Properties, Tissue Fixation, Transducers, Ultrasonography, Interventional, Vacuoles, Videotape Recording, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundIntravascular ultrasound (IVUS) images vary in intensity because of the angle of the transducer relative to the plaque. The purpose of this study was to determine the angle dependence of ultrasound backscatter when the IVUS transducer is aligned coaxially in atherosclerotic arteries and to examine its feasibility in tissue characterization of human atherosclerotic tissue.Methods and resultsThirty-nine noncalcified regions of interest (ROI, 0.4 to 0. 6 mm in diameter) within cross sections of formalin-fixed human iliac arterial plaque were imaged with a 3.9F, 25-MHz IVUS catheter in saline at room temperature. The catheter was moved coaxially from 8 to 16 positions and spanned 50 to 122 degrees relative to the ROI and the lumen center. Echo intensity for each ROI was defined as the videointensity relative to a standard reflector. The angle dependence of echo intensity was defined as the slope of the regression line between the angle of incidence and echo intensity. Each ROI was histologically classified into 4 groups: fibro-acellular (fibrous cap, n=7), fibro-cellular (n=9), fibro-fatty (n=13), or fatty tissue (n=10). The echo intensity of the majority (72%) of plaque components in IVUS images are significantly affected by the angle of incidence of the transducer. The angle dependence of fibro-acellular samples was significantly greater than that of the other 3 groups (4.69 +/- 3.29 x 10(-3) x echo intensity/degree vs 1.06 +/- 1.10 in fibro-cellular area, 2.09 +/- 1.75 in fibro-fatty area, and 2.16 +/- 1.92 in fatty area, P

Published
1999

20. Current and future perspective of IVUS tissue characterization of atherosclerotic plaque

Author

Hiro, Takafumi, Fujii, Takashi, Tobis, Jonathan M, and Matsuzaki, Masunori

Abstract

血管内エコー法(IVUS)では,以前より病理学的分類としての線維性hard plaqueと脂肪性soft plaqueに対応させるかのように,プラークのエコー輝度に応じて高輝度のものをhard plaque,低輝度度のものをs o f t p l a q u e とする分類が用いられる.しかし,著者らの検討によれば,プラークの線維領域および脂肪領域が,それぞれ必ず高輝度,低輝度に描出されるわけではなく,かなりの割合で逆に描出されうることが判明した。また,IVUSの機種によって画像が有意に違うことや,プラークの物理的硬度と比較しても低輝度ほど"soft"であるわけではないこともわかった.この限界を克服するため,これまでにRF信号を直接スペクトル解析する方法などが注目されているが,著者らはFractal解析やプラークのエコー輝度が超音波入射角度に依存性であることを利用して,組織性状を推定する方法を提唱してきた.その中で画像のFractal次元が線維領域で有意に低いことや,エコー輝度の超音波入射角度依存性がfibrous capに特に強く認められることが判明した.これらの画像処理法は,今後プラークの不安定性の定量評価に応用できる可能性を示唆していると考えられた.その他,三次元や長軸再構築像などを含めてIVUS技術は年々革新しており,動脈硬化プラークの組織性状診断の分野におけるIVUSの新たなる未来が期待される.

Published
1999

23. Clinical feasibility of 0.018-inch intravascular ultrasound imaging device

Author

Hiro, Takafumi, Hall, Patrick, Maiello, Luigi, Itoh, Akira, Colombo, Antonio, Jang, Yue-Teh, Salmon, Stephen M, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Bioengineering, Clinical Research, Biomedical Imaging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Cardiac Catheterization, Equipment Design, Feasibility Studies, Humans, Transducers, Ultrasonography, Interventional, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

OBJECTIVES:Intravascular ultrasound imaging (IVUS) is limited by the size of the imaging catheter. To facilitate imaging before and during interventions, a 30-MHz ultrasonic imaging device was developed that is the same dimension as a 0.018-inch guide wire. The purpose of this study was to evaluate the clinical feasibility of this device. METHODS AND RESULTS:The imaging core was tested in 8 patients with the use of a monorail guiding sheath that was advanced through a 7F catheter. In addition, after coronary interventions, the standard guide wire was removed, the imaging core was placed inside a compatible balloon, and imaging was performed. In 4 patients, imaging was also performed with a standard 3.2F IVUS catheter. The lumen-plaque interface and the media-plaque interface were clearly visualized in all patients. There was no detectable loss in image quality between the new imaging device and the larger IVUS catheter, and measurements of lumen cross-sectional area were not statistically different. CONCLUSIONS:Improvements in manufacturing technology have permitted the development of a mechanically rotating ultrasound imaging core 0.018 inches in diameter. It is compatible with current balloon catheters without degradation of image quality.

Published
1998

24. Are soft echoes really soft? Intravascular ultrasound assessment of mechanical properties in human atherosclerotic tissue

Author

Hiro, Takafumi, Leung, Cyril Y, De Guzman, Sarah, Caiozzo, Vincent J, Farvid, Ali R, Karimi, Houshang, Helfant, Richard H, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Biomedical Imaging, Bioengineering, Cardiovascular, Atherosclerosis, Adult, Aged, Aged, 80 and over, Analysis of Variance, Arteriosclerosis, Cadaver, Humans, Iliac Artery, Middle Aged, Predictive Value of Tests, Sensitivity and Specificity, Ultrasonography, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

To examine the accuracy of intravascular ultrasound (IVUS) in assessing the biophysical properties of atherosclerotic plaque, 33 human iliac arteries were imaged with a 25 MHz IVUS transducer and classified into four groups on the basis of IVUS appearance: minimally diseased arterial wall, bright echogenic plaque with acoustic shadowing, bright echogenic plaque without shadowing, and hypoechogenic plaque (so-called "soft echoes"). The hardness of each plaque was assessed with an ultrasensitive compression ergonometer. The radial static stress-strain relations fit well (r > 0.98) to exponential curves, providing a compression stiffness constant (K) defined as the coefficient of the exponential power. K for bright echogenic plaque with shadowing was significantly greater than that of the other tissues. However, K among minimally diseased entire arterial wall, hypoechogenic plaque, and bright echogenic plaque without shadowing was not significantly different, but these tissues are not physically soft compared with adipose tissue. Therefore, tissue characterization by IVUS distinguishes calcified from noncalcified plaque and accurately predicts its biomechanical hardness. However, soft echoes, although less firm than calcium, do not necessarily correspond to soft tissue.

Published
1997

25. Intravascular ultrasound identification of stent entrapment in vivo with in vitro confirmation

Author

Hiro, Takafumi, Leung, Cyril Y, Russo, Robert J, Teirstein, Paul, Yeatman, Lawrence A, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Assistive Technology, Biomedical Imaging, Cardiovascular, Bioengineering, Angioplasty, Balloon, Coronary Angiography, Coronary Disease, Equipment Safety, Foreign-Body Migration, Humans, In Vitro Techniques, Male, Middle Aged, Stents, Ultrasonography, Interventional, stent jail, coronary artery, Palmaz-Schatz stent, Gianturco-Roubin stent, Cardiovascular System & Hematology
Abstract

ObjectivesOne potential complication of stenting is "stent jail" due to placement of a stent across a side branch, which may impede additional interventions. Another form of stent entrapment may occur if the guidewire is accidentally withdrawn and then unknowingly passes through a stent loop during reentry with subsequent high pressure expansion. The purpose of this study was to evaluate this form of stent entrapment in vitro by intravascular ultrasound (IVUS).MethodsA guidewire was passed through the end or middle diamonds of Palmaz-Schatz and Palmaz stents or the middle of Gianturco-Roubin stents. A 3.5 mm balloon was inflated over the guidewire through the various side holes of the stents.ResultsIVUS images presented three distinct patterns depending on the type of stent and position of balloon entry: 1) external compression and loss of wall continuity in the Palmaz-Schatz and Palmaz stents, 2) displacement of the side diamond across the lumen, and 3) external compression of the Gianturco-Roubin stent. The first and second patterns but not the third one were associated with impairment of lumen access.ConclusionsBased upon this in vitro verification, IVUS imaging can be used to identify the presence of stent entrapment in vivo.

Published
1997

26. In vitro atherosclerotic plaque and calcium quantitation by intravascular ultrasound and electron-beam computed tomography

Author

Gutfinger, Dan E, Leung, Cyril Y, Hiro, Takafumi, Maheswaran, Bavani, Nakamura, Shigeru, Detrano, Robert, Kang, Xingping, Tang, Weiyi, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Clinical Research, Biomedical Imaging, Adolescent, Adult, Aged, Aged, 80 and over, Arteriosclerosis, Cadaver, Calcium, Female, Humans, Iliac Artery, In Vitro Techniques, Male, Microscopy, Electron, Scanning, Middle Aged, Models, Theoretical, Tomography, Emission-Computed, Ultrasonography, Interventional, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

The purpose of this investigation was to compare the accuracy of intravascular ultrasound (IVUS) and electron-beam computed tomography (EBCT) in quantitating human atherosclerotic plaque and calcium. In experiment 1, 12 human atherosclerotic arterial segments were obtained at autopsy and imaged by using IVUS and EBCT. The plaque from each arterial segment was dissected and a volume measurement of the dissected plaque was obtained by water displacement. The plaque from each arterial segment was ashed at 700 degrees F, and the weight of the remaining ashes was used as an estimate of the calcium mass. In experiment II, 11 calcified arterial segments were obtained at autopsy and imaged by using IVUS at one site along the artery. A corresponding histologic cross section stained with Masson's trichrome was prepared. In experiment I, the mean plaque volume measured by water displacement was 165.3 +/- 118.4 microliters. The mean plaque volume calculated by IVUS was 166.1 +/- 114.4 microliters and correlated closely with that by water displacement (r = 0.98, p < 0.0001). The mean calcium mass measured by ashing was 19.4 +/- 15.8 mg. The mean calculated calcium mass by EBCT was 19.9 mg and correlated closely with that by ashing (r=0.98, p

Published
1996

27. Effect of Saxagliptin on Endothelial Function in Patients with Type 2 Diabetes: A Prospective Multicenter Study

Author

Kajikawa, Masato, Maruhashi, Tatsuya, Hidaka, Takayuki, Matsui, Shogo, Hashimoto, Haruki, Takaeko, Yuji, Nakano, Yukiko, Kurisu, Satoshi, Kihara, Yasuki, Yusoff, Farina Mohamad, Kishimoto, Shinji, Chayama, Kazuaki, Goto, Chikara, Noma, Kensuke, Nakashima, Ayumu, Hiro, Takafumi, Hirayama, Atsushi, Shiina, Kazuki, Tomiyama, Hirofumi, Yagi, Shusuke, Amano, Rie, Yamada, Hirotsugu, Sata, Masataka, and Higashi, Yukihito

Published
2019
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28. Fractal geometry of coronary plaque images within optical coherence tomography: A novel approach of plaque vulnerability in patients with acute coronary syndrome versus stable angina pectoris

Author

Morikawa, Tomoyuki, primary, Hiro, Takafumi, additional, Mineki, Takashi, additional, Kojima, Keisuke, additional, Kogo, Takaaki, additional, Iida, Korehito, additional, Akutsu, Naotaka, additional, Murata, Nobuhiro, additional, Sudo, Mitsumasa, additional, Kitano, Daisuke, additional, Fukamachi, Daisuke, additional, and Okumura, Yasuo, additional

Published
2023
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29. Intravascular ultrasound appearance of normal and mildly diseased coronary arteries: Correlation with histologic specimens

Author

Maheswaran, Bavani, Leung, Cyril Y, Gutfinger, Dan E, Nakamura, Shigeru, Russo, Robert J, Hiro, Takafumi, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Biomedical Imaging, Cardiovascular, Adolescent, Adult, Aged, Aged, 80 and over, Coronary Artery Disease, Coronary Disease, Coronary Vessels, Female, Humans, Hyperplasia, Male, Middle Aged, Tunica Intima, Ultrasonography, Interventional, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

Intravascular ultrasound imaging was performed in vitro on six histologically normal and 104 minimally diseased arteries in patients aged 13 to 83 years. This study tested the hypothesis that normal coronary arteries produce a three-layer image that corresponds to the histologic layers of intima, media, and adventitia. The results showed a very good correlation between area of the echolucent ultrasound layer with the media and the inner echogenic layer with intimal area. In addition, a three-layer appearance was consistently seen when the internal elastic membrane was present with or without intimal hyperplasia. If the internal elastic membrane was absent, a three-layer appearance was still seen if the collagen content of the media was low. However, a two-layer appearance was observed when there was absence of the internal elastic membrane as well as a high collagen content of the media.

Published
1995

30. 1004-54 Correlation of Intravascular Ultrasound Imaging with Histology of Normal and Diseased Pulmonary Arteries

Author

Leung, Cyril Y, Hiro, Takafumi, de Guzman, Sarah, Farvid, Ali R, Karimi, Houshang, Sylora, John, and Tobis, Jonathan M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Biomedical Imaging, Cardiovascular, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Published
1995

31. Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study

Author

Okumura, Yasuo, primary, Nagashima, Koichi, additional, Watanabe, Ryuta, additional, Yokoyama, Katsuaki, additional, Kato, Takeshi, additional, Fukaya, Hidehira, additional, Hayashi, Hidemori, additional, Nakahara, Shiro, additional, Shimizu, Wataru, additional, Iwasaki, Yu-ki, additional, Fujimoto, Yuhi, additional, Mukai, Yasushi, additional, Ejima, Koichiro, additional, Otsuka, Takayuki, additional, Suzuki, Shinya, additional, Murakami, Masato, additional, Kimura, Masaomi, additional, Harada, Masahide, additional, Koyama, Junjiroh, additional, Okamatsu, Hideharu, additional, Yamane, Teiichi, additional, Yamashita, Seigo, additional, Tokuda, Michifumi, additional, Narui, Ryohsuke, additional, Takami, Mitsuru, additional, Shoda, Morio, additional, Harada, Tomoo, additional, Nakajima, Ikutaro, additional, Fujiu, Katsuhito, additional, Hiroshima, Kenichi, additional, Tanimoto, Kojiro, additional, Fujino, Tadashi, additional, Nakamura, Keijiro, additional, Kumagai, Koji, additional, Okada, Ayako, additional, Kobayashi, Hideki, additional, Hayashi, Tatsuya, additional, Watari, Yuji, additional, Hatsuno, Mina, additional, Tachibana, Eizo, additional, Iso, Kazuki, additional, Sonoda, Kazumasa, additional, Aizawa, Yoshiyasu, additional, Chikata, Akio, additional, Sakagami, Satoru, additional, Inoue, Masaru, additional, Minamiguchi, Hitoshi, additional, Makino, Nobuhiko, additional, Satomi, Kazuhiro, additional, Yazaki, Yoshinao, additional, Aoyagi, Hideshi, additional, Ichikawa, Makoto, additional, Haruta, Hironori, additional, Hiro, Takafumi, additional, Okubo, Kimie, additional, Arima, Ken, additional, Tojo, Taiki, additional, Kihara, Hajime, additional, Miyanaga, Satoru, additional, Fukuda, Yoshiaki, additional, Oiwa, Koji, additional, Fujiishi, Tamami, additional, Akabane, Masashi, additional, Ishikawa, Norikazu, additional, Kusano, Kengo, additional, Miyamoto, Koji, additional, Tabuchi, Haruna, additional, Shiozawa, Tomoyuki, additional, Miyamoto, Kenjiro, additional, Mase, Hiroshi, additional, and Murotani, Kenta, additional

Published
2023
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35. Automatic Plaque Boundary Extraction in Intravascular Ultrasound Image by Fuzzy Inference with Adaptively Allocated Membership Functions

Author

Uchino, Eiji, Suetake, Noriaki, Koga, Takanori, Ichiyama, Shohei, Hashimoto, Genta, Hiro, Takafumi, Matsuzaki, Masunori, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Köppen, Mario, editor, Kasabov, Nikola, editor, and Coghill, George, editor

Published
2009
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36. Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Risk in Statin-Treated Patients with Coronary Artery Disease

Author

Ishii, Junnichi, primary, Kashiwabara, Kosuke, additional, Ozaki, Yukio, additional, Takahashi, Hiroshi, additional, Kitagawa, Fumihiko, additional, Nishimura, Hideto, additional, Ishii, Hideki, additional, Iimuro, Satoshi, additional, Kawai, Hideki, additional, Muramatsu, Takashi, additional, Naruse, Hiroyuki, additional, Iwata, Hiroshi, additional, Tanizawa-Motoyama, Sadako, additional, Ito, Hiroyasu, additional, Watanabe, Eiichi, additional, Matsuyama, Yutaka, additional, Fukumoto, Yoshihiro, additional, Sakuma, Ichiro, additional, Nakagawa, Yoshihisa, additional, Hibi, Kiyoshi, additional, Hiro, Takafumi, additional, Hokimoto, Seiji, additional, Miyauchi, Katsumi, additional, Ohtsu, Hiroshi, additional, Izawa, Hideo, additional, Ogawa, Hisao, additional, Daida, Hiroyuki, additional, Shimokawa, Hiroaki, additional, Saito, Yasushi, additional, Kimura, Takeshi, additional, Matsuzaki, Masunori, additional, and Nagai, Ryozo, additional

Published
2022
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40. A case of giant saphenous vein graft aneurysm followed serially after coronary artery bypass surgery

Author

Takayama Tadateru, Akutsu Naotaka, Hiro Takafumi, Oya Toshiyuki, Fukamachi Daisuke, Haruta Hironori, Iida Korehito, Kougo Takaaki, Mineki Takashi, Nishida Toshihiko, Murata Nobuhiro, Oshima Toru, Hata Hiroaki, Shiono Motomi, and Hirayama Atsushi

Subjects
Vein graft aneurysm, CABG, off-pump surgery, Medicine
Abstract

Saphenous vein graft aneurysm (SVGA) is one of the chronic complications after coronary aorta bypass grafting (CABG) and may be caused by atherosclerosis-like phenomena of the vein graft, weakness around the vein valve, rupturing of the suture of the graft anastomosis, or perioperative graft injury. We describe a case of a large, growing saphenous vein graft aneurysm that was followed serially by chest radiography and computed tomography. Eighteen years after CABG, an SVGA (23 × 24 mm) was incidentally detected. The patient was asymptomatic and was followed conservatively. Four years later, coronary computed tomographic angiography showed that the giant aneurysm had grown to 52.1 by 63.8 mm and revealed a second, smaller aneurysm. Finally, the SVG was ultimately resected without bypass via off-pump surgery. Therefore, this case suggested that aggressive treatment that includes surgical intervention should be considered before the aneurysm becomes larger, even if it is asymptomatic.

Published
2016
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46. High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins : An Observation from the REAL-CAD Study

Author

Omote, Kazunori, Yokota, Isao, Nagai, Toshiyuki, Sakuma, Ichiro, Nakagawa, Yoshihisa, Kamiya, Kiwamu, Iwata, Hiroshi, Miyauchi, Katsumi, Ozaki, Yukio, Hibi, Kiyoshi, Hiro, Takafumi, Fukumoto, Yoshihiro, Mori, Hiroyoshi, Hokimoto, Seiji, Ohashi, Yasuo, Ohtsu, Hiroshi, Ogawa, Hisao, Daida, Hiroyuki, Iimuro, Satoshi, Shimokawa, Hiroaki, Saito, Yasushi, Kimura, Takeshi, Matsuzaki, Masunori, Nagai, Ryozo, Anzai, Toshihisa, Omote, Kazunori, Yokota, Isao, Nagai, Toshiyuki, Sakuma, Ichiro, Nakagawa, Yoshihisa, Kamiya, Kiwamu, Iwata, Hiroshi, Miyauchi, Katsumi, Ozaki, Yukio, Hibi, Kiyoshi, Hiro, Takafumi, Fukumoto, Yoshihiro, Mori, Hiroyoshi, Hokimoto, Seiji, Ohashi, Yasuo, Ohtsu, Hiroshi, Ogawa, Hisao, Daida, Hiroyuki, Iimuro, Satoshi, Shimokawa, Hiroaki, Saito, Yasushi, Kimura, Takeshi, Matsuzaki, Masunori, Nagai, Ryozo, and Anzai, Toshihisa

Abstract

Aim: The association between high-density lipoprotein cholesterol (HDL-C) level after statin therapy and cardiovascular events in patients with stable coronary artery disease (CAD) remains unclear. Thus, in this study, we sought to determine how HDL-C level after statin therapy is associated with cardiovascular events in stable CAD patients. Methods: From the REAL-CAD study which had shown the favorable prognostic effect of high-dose pitavastatin in stable CAD patients with low-density lipoprotein cholesterol (LDL-C) <120 mg/dL, 9,221 patients with HDL-C data at baseline and 6 months, no occurrence of primary outcome at 6 months, and reported non-adherence for pitavastatin, were examined. The primary outcome was a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, or unstable angina requiring emergent admission after 6 months of randomization. Absolute difference and ratio of HDL-C levels were defined as (those at 6 months-at baseline) and (absolute difference/baseline) x 100, respectively. Results: During a median follow-up period of 4.0 (IQR 3.2-4.7) years, the primary outcome occurred in 417 (4.5%) patients. The adjusted risk of all HDL-C-related variables (baseline value, 6-month value, absolute, and relative changes) for the primary outcome was not significant (hazard ratio [HR] 0.99, 95% confidence interval [CI] 0.91-1.08, HR 1.03, 95% CI 0.94-1.12, HR 1.05, 95% CI 0.98-1.12, and HR 1.08, 95% CI 0.94-1.24, respectively). Furthermore, adjusted HRs of all HDL-C-related variables remained non-significant for the primary outcome regardless of on-treatment LDL-C level at 6 months. Conclusions: After statin therapy with modestly controlled LDL-C, HDL-C level has little prognostic value in patients with stable CAD.

Published
2022

47. Clinically evident polyvascular disease and regression of coronary atherosclerosis after intensive statin therapy in patients with acute coronary syndrome: Serial intravascular ultrasound from the Japanese assessment of pitavastatin and atorvastatin in acute coronary syndrome (JAPAN-ACS) trial

Author

Hibi, Kiyoshi, Kimura, Takeshi, Kimura, Kazuo, Morimoto, Takeshi, Hiro, Takafumi, Miyauchi, Katsumi, Nakagawa, Yoshihisa, Yamagishi, Masakazu, Ozaki, Yukio, Saito, Satoshi, Yamaguchi, Tetsu, Daida, Hiroyuki, and Matsuzaki, Masunori

Published
2011
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49. Correlation between circulating adiponectin levels and coronary plaque regression during aggressive lipid-lowering therapy in patients with acute coronary syndrome: Subgroup analysis of JAPAN-ACS study

Author

Ohashi, Taiki, Shibata, Rei, Morimoto, Takeshi, Kanashiro, Masaaki, Ishii, Hideki, Ichimiya, Satoshi, Hiro, Takafumi, Miyauchi, Katsumi, Nakagawa, Yoshihisa, Yamagishi, Masakazu, Ozaki, Yukio, Kimura, Takeshi, Daida, Hiroyuki, Murohara, Toyoaki, and Matsuzaki, Masunori

Published
2010
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50. High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins: An Observation from the REAL-CAD Study

Author

Omote, Kazunori, primary, Yokota, Isao, additional, Nagai, Toshiyuki, additional, Sakuma, Ichiro, additional, Nakagawa, Yoshihisa, additional, Kamiya, Kiwamu, additional, Iwata, Hiroshi, additional, Miyauchi, Katsumi, additional, Ozaki, Yukio, additional, Hibi, Kiyoshi, additional, Hiro, Takafumi, additional, Fukumoto, Yoshihiro, additional, Mori, Hiroyoshi, additional, Hokimoto, Seiji, additional, Ohashi, Yasuo, additional, Ohtsu, Hiroshi, additional, Ogawa, Hisao, additional, Daida, Hiroyuki, additional, Iimuro, Satoshi, additional, Shimokawa, Hiroaki, additional, Saito, Yasushi, additional, Kimura, Takeshi, additional, Matsuzaki, Masunori, additional, Nagai, Ryozo, additional, and Anzai, Toshihisa, additional

Published
2022
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