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5 results on '"Hiroko Bamba"'

1. Polymorphisms of the TNF gene and the TNF receptor superfamily member 1B gene are associated with susceptibility to ulcerative colitis and Crohn's disease, respectively

Author

Koji Sawada, K. Tamura, Masamichi Satomi, Kazuo Tamura, Tadashi Kosaka, Hiroko Bamba, Hiroko Sashio, Yoshihiro Fukuda, Takashi Shimoyama, Yoshihiro Yamamoto, Reiko Ito, Shin Fukui, and Jun-ichi Furuyama

Subjects
Adult, Male, Adolescent, Immunology, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Inflammatory bowel disease, Receptors, Tumor Necrosis Factor, Exon, Crohn Disease, Gene Frequency, Antigens, CD, Genetics, medicine, Humans, Receptors, Tumor Necrosis Factor, Type II, Child, Gene, Alleles, Aged, Crohn's disease, Tumor Necrosis Factor-alpha, Haplotype, Middle Aged, medicine.disease, Ulcerative colitis, Haplotypes, Receptors, Tumor Necrosis Factor, Type I, Case-Control Studies, Colitis, Ulcerative, Female, Tumor necrosis factor alpha
Abstract

The importance of tumor necrosis factor (TNF)-alpha and the TNF receptor gene polymorphisms in the etipathogenesis of inflammatory bowel disease (IBD) has not been elucidated. DNA from peripheral blood samples was obtained from 124 patients with Crohn's disease (CD), 106 patients with ulcerative colitis (UC), and 111 unrelated healthy controls. We examined two single nucleotide polymorphisms (SNPs) of the TNF-alpha gene, TNF (–308 G/A and –238 G/A), an SNP of the TNF receptor superfamily member 1A gene, TNFRSF1A(also known as TNFR1), at codon 12 in exon 1 (CCA/CCG), and two SNPs of the 1B gene, TNFRSF1B (also known as TNFR2), (1466 A/G and 1493 C/T). There was a difference in the carrier frequency for haplotype AG (–308 A, –238 G) between UC patients and the controls (OR=4.76, 95% CI=1.53–14.74, P

Published
2002
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2. Title Page / Contents / Members of the Symposium / Preface / Introductory Remarks

Author

Masataka Kojima, Masanori Okui, Hiroshi Kiyono, Hironobu Sasano, Kazunori Tashiro, Hitoshi Asakura, Keiichi Mitsuyama, Toshiro Sato, Haruo Otani, Zhang-xu Liu, Kisei Ishizuka, Toshifumi Hibi, Mitsunori Noguchi, Hiroshi Serizawa, Osamu Kanauchi, Ken Toshina, Atsushi Toyonaga, Takayoshi Toyota, Yuji Naito, Hiroshi Nagura, Nobuo Okabe, Ryota Hokari, Hidekazu Suzuki, Michio Sata, Asuka Suzuki, Kazuhito Sugimura, Masaaki Adachi, Yuji Hinoda, Tomoyuki Tsujikawa, Nobuhide Oshitani, Hiroko Bamba, Taiji Yamaguchi, Soichiro Miura, Shiro Nakamura, Ken-ichi Katsu, Yoshihiro Fukuda, Yoh Ishiguro, Yoshihide Fujiyama, Tsutomu Mochizuki, Masatoshi Nitta, Toshio Kimura, Yoshikazu Tsuzuki, Jun-ichi Hara, Akira Andoh, Terasu Homma, Kouji Suzuki, Yuriko Hara, Mi-Na Kweon, Hiroyoshi Utsumi, Tetsuo Arakawa, Tohru Takahashi, Takanori Kanai, Akihiro Munakata, Nobuo Tomiyasu, Hiroyuki Sakata, Haruo Ohtani, Yoshinori Sawa, Toshihiko Iwanaga, Masamichi Satomi, Yoshio Araki, Tadao Bamba, Fumio Itoh, Satoshi Motoya, Kosuke Takaki, Kazufumi Yamagata, Mitsuyuki Murano, Ichiro Takahashi, Bin Wu, Kohzoh Imai, Ichiro Hirata, Kazuaki Otsuka, Kazuma Fujimoto, Hirotake Sakuraba, Kentaro Maemura, Noritoshi Tanida, Hiromasa Ishii, Akira Okazawa, Takayuki Matsumoto, Osamu Yamaguchi, Toshikazu Yoshikawa, Shin-ichi Sasaki, Takashi Nishigami, Hiroshi Kanazawa, Yasunari Nakamura, Jun Matsuzawa, Takahiro Noda, Mamoru Watanabe, Norimasa Yoshida, Yoshio Jinno, Toshiaki Hayashi, Shunsuke Komoto, Shuji Nakagawa, Takashi Shimoyama, Masaaki Kobayashi, Ryuichi Iwakiri, Seiichiro Koseki, Tadao Ishida, Kazutami Tamura, Hitoshi Fujimori, Sadatoshi Ishibashi, and Nobuo Hiwatashi

Subjects
media_common.quotation_subject, Gastroenterology, Art, Title page, Classics, media_common
Published
2001
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3. Helicobacter pylori Infection Increases Mucosal Permeability of the Stomach and Intestine

Author

Noritoshi Tanida, Masanori Okui, Takashi Shimoyama, Takashi Nishigami, Masamichi Satomi, Kazutami Tamura, Hiroko Bamba, and Yoshihiro Fukuda

Subjects
Sucrose, biology, Spirillaceae, Stomach, Gastroenterology, Biological activity, Helicobacter pylori, biology.organism_classification, Microbiology, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Antigen, Intestinal mucosa, Immunology, medicine, Gastritis, medicine.symptom
Abstract

It is important to study the effect of Helicobacter pylori infection on the permeability of the intestine. Permeability was evaluated by oral sucrose tolerance test using sucrose 25 g in 200 ml of water. Existence of H. pylori itself was associated with increased permeability of sucrose. Also, the permeability of sucrose increased as polymorphonuclear and lymphocyte infiltration increased. The increase of mucosal permeability suggests that antigens like protein penetrate into the body and result in systemic reactions. Thus, it is important to study the implication of increased permeability in relation not only to gastric diseases but also certain systemic diseases.

Published
2001
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4. IL18 polymorphism is associated with an increased risk of Crohn's disease

Author

Yoshihiro Yamamoto, Takehira Yamamura, Kazuo Tamura, Shin Fukui, Takashi Shimoyama, Masamichi Satomi, Koji Sawada, Hiroko Bamba, Haruki Okamura, Takahiro Yamada, Tadashi Kosaka, Hiroko Sashio, Yoshihiro Fukuda, Naohisa Takeda, K. Tamura, and Jun-ichi Furuyama

Subjects
Adult, Male, Adolescent, Genotype, Molecular Sequence Data, Single-nucleotide polymorphism, Disease, Inflammatory bowel disease, Polymerase Chain Reaction, Risk Assessment, Sensitivity and Specificity, Sampling Studies, Proinflammatory cytokine, Pathogenesis, Age Distribution, Crohn Disease, Reference Values, medicine, Genetic predisposition, Confidence Intervals, Odds Ratio, Humans, Genetic Predisposition to Disease, Sex Distribution, Aged, Probability, Crohn's disease, Polymorphism, Genetic, Base Sequence, business.industry, Incidence, Gastroenterology, Interleukin-18, Middle Aged, medicine.disease, Ulcerative colitis, digestive system diseases, Case-Control Studies, Immunology, Colitis, Ulcerative, Female, business
Abstract

Background. The etiology of inflammatory bowel disease, which includes ulcerative colitis and Crohn’s disease, has not yet been made clear. However, inflammatory bowel disease is recognized as a multifactorial disease, and innate genetic factors might contribute to the pathogenesis. Cytokine genes are thought to be important in inflammatory bowel disease. Recently, interleukin 18, cloned as a novel proinflammatory cytokine, has been implicated in inflammatory bowel disease, especially Crohn’s disease. Methods. To identify germline mutations in patients with inflammatory bowel disease, the entire coding region of IL18 was examined using a DNA sequencing procedure. Results. No functional mutations were found, but a novel single nucleotide polymorphism (SNP) was identified as TCA/ TCC at codon 35. In patients with Crohn’s disease, the frequency of TCC allele carriers was significantly higher than in healthy controls (χ2 = 9.35, P = 0.002229, OR = 2.58, 95% CI = 1.39–4.80). Also, the magnitude of the association was more remarkable in females (χ 2 = 16.36, P = 0.000052, OR = 8.17, 95% CI = 2.73–24.41). The TCC allele at codon 35 of IL18 may increase the risk for Crohn’s disease, especially in females. Conclusions. IL18 is probably one of several genes that determine susceptibility to Crohn’s disease.

Published
2003

5. Author and Subject Index

Author

Kisei Ishizuka, Mi-Na Kweon, Masaaki Adachi, Akihiro Munakata, Ryota Hokari, Terasu Homma, Yoshio Jinno, Zhang-xu Liu, Masamichi Satomi, Akira Andoh, Kosuke Takaki, Nobuo Hiwatashi, Haruo Otani, Masataka Kojima, Hiroyuki Sakata, Tetsuo Arakawa, Satoshi Motoya, Atsushi Toyonaga, Kazufumi Yamagata, Nobuo Tomiyasu, Toshiaki Hayashi, Ichiro Takahashi, Yoshinori Sawa, Kazuaki Otsuka, Osamu Kanauchi, Ken Toshina, Takayuki Matsumoto, Nobuhide Oshitani, Noritoshi Tanida, Shunsuke Komoto, Michio Sata, Asuka Suzuki, Toshikazu Yoshikawa, Mitsuyuki Murano, Hiroshi Kiyono, Takashi Shimoyama, Hiroko Bamba, Mamoru Watanabe, Yoshihiro Fukuda, Toshio Kimura, Yoshihide Fujiyama, Yoshikazu Tsuzuki, Hirotake Sakuraba, Tadao Bamba, Toshifumi Hibi, Kentaro Maemura, Shuji Nakagawa, Hitoshi Asakura, Soichiro Miura, Shiro Nakamura, Yoh Ishiguro, Sadatoshi Ishibashi, Ryuichi Iwakiri, Yasunari Nakamura, Taiji Yamaguchi, Tsutomu Mochizuki, Keiichi Mitsuyama, Haruo Ohtani, Mitsunori Noguchi, Kouji Suzuki, Toshiro Sato, Takanori Kanai, Kazuma Fujimoto, Kazuhito Sugimura, Hidekazu Suzuki, Seiichiro Koseki, Masatoshi Nitta, Kohzoh Imai, Tadao Ishida, Kazutami Tamura, Yoshio Araki, Hiromasa Ishii, Hitoshi Fujimori, Jun-ichi Hara, Toshihiko Iwanaga, Tohru Takahashi, Akira Okazawa, Hironobu Sasano, Yuriko Hara, Takayoshi Toyota, Fumio Itoh, Hiroyoshi Utsumi, Norimasa Yoshida, Bin Wu, Masaaki Kobayashi, Hiroshi Serizawa, Shin-ichi Sasaki, Tomoyuki Tsujikawa, Hiroshi Kanazawa, Masanori Okui, Nobuo Okabe, Osamu Yamaguchi, Jun Matsuzawa, Takahiro Noda, Yuji Hinoda, Kazunori Tashiro, Ichiro Hirata, Yuji Naito, Hiroshi Nagura, Ken-ichi Katsu, and Takashi Nishigami

Subjects
medicine.medical_specialty, Index (economics), business.industry, Gastroenterology, Medicine, Subject (documents), Medical physics, business, Surgery
Published
2001
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