Search

Your search keyword '"Hirota, Masato"' showing total 35 results
Start Over Author "Hirota, Masato"
35 results on '"Hirota, Masato"'

2. Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

Author

Hirota, Masato, Tamai, Miho, Yukawa, Sachie, Taira, Naoyuki, Matthews, Melissa M., Toma, Takeshi, Seto, Yu, Yoshida, Makiko, Toguchi, Sakura, Miyagi, Mio, Mori, Tomoari, Tomori, Hiroaki, Tamai, Osamu, Kina, Mitsuo, Sakihara, Eishin, Yamashiro, Chiaki, Miyagi, Masatake, Tamaki, Kentaro, Wolf, Matthias, Collins, Mary K., Kitano, Hiroaki, and Ishikawa, Hiroki

Published
2023
Full Text
View/download PDF

6. Human immune and gut microbial parameters associated with inter-individual variations in COVID-19 mRNA vaccine-induced immunity

Author

Hirota, Masato, primary, Tamai, Miho, additional, Yukawa, Sachie, additional, Taira, Naoyuki, additional, Matthews, Melissa M., additional, Toma, Takeshi, additional, Seto, Yu, additional, Yoshida, Makiko, additional, Toguchi, Sakura, additional, Miyagi, Mio, additional, Mori, Tomoari, additional, Tomori, Hiroaki, additional, Tamai, Osamu, additional, Kina, Mitsuo, additional, Sakihara, Eishin, additional, Yamashiro, Chiaki, additional, Miyagi, Masatake, additional, Tamaki, Kentaro, additional, Wolf, Matthias, additional, Collins, Mary K., additional, Kitano, Hiroaki, additional, and Ishikawa, Hiroki, additional

Published
2022
Full Text
View/download PDF

15. Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis

Author

Yamada, Takahiro, primary, Hino, Shingo, additional, Iijima, Hideki, additional, Genda, Tomomi, additional, Aoki, Ryo, additional, Nagata, Ryuji, additional, Han, Kyu-Ho, additional, Hirota, Masato, additional, Kinashi, Yusuke, additional, Oguchi, Hiroyuki, additional, Suda, Wataru, additional, Furusawa, Yukihiro, additional, Fujimura, Yumiko, additional, Kunisawa, Jun, additional, Hattori, Masahira, additional, Fukushima, Michihiro, additional, Morita, Tatsuya, additional, and Hase, Koji, additional

Published
2019
Full Text
View/download PDF

16. Regulation of inflammatory response of macrophages and induction of regulatory T cells by using retinoic acid-loaded nanostructured lipid carrier

Author

Zai, Khadijah, Ishihara, Narumi, Oguchi, Hiroyuki, Hirota, Masato, Kishimura, Akihiro, Mori, Takeshi, Hase, Koji, and Katayama, Yoshiki

Subjects
organic chemicals, neoplasms
Abstract

Immunomodulatory function of all-trans retinoic acid (ATRA) has been gathering much attention for the therapy of autoimmune diseases. ATRA is a chemically unstable molecule which requires proper formulation for targeted delivery. Here we examined nanostructured lipid carrier (NLC) for the formulation of ATRA. NLC is a representative nanoparticle formulation especially suited for oral delivery. We established the preparation procedures of ATRA-containing NLC (NLC-RA) which minimizes the degradation of ATRA during the preparation process. NLC-RA thus obtained was taken up by macrophages and induced anti-inflammatory response via suppressing NF-κB signaling as well as via enhancing the production of anti-inflammatory cytokines. Moreover, NLC-RA enhanced differentiation of naïve T cells to regulatory T cells in the co-culture system with dendritic cells. These results suggest that NLC-RA is a promising alternative therapy for the autoimmune diseases especially intestinal bowel disease.

Published
2019
Full Text
View/download PDF

17. A partial agonist for retinoid X receptor mitigates experimental colitis

Author

Fujihara Michiko, Makishima Makoto, Takahashi Daisuke, Kakuta Hiroki, Suzuki Koichiro, Shibahara Osamu, Furusawa Yukihiro, Onuki Masayoshi, Nishii Midori, Watanabe Masaki, Egawa Aiko, Hase Koji, Ishihara Narumi, Hirota Masato, Takizawa Kei, and Yamada Takahiro

Subjects
0301 basic medicine, Agonist, Lipopolysaccharides, Male, Nerve growth factor IB, Docosahexaenoic Acids, Tetrahydronaphthalenes, medicine.drug_class, Immunology, Retinoid X receptor, Pharmacology, Inflammatory bowel disease, Partial agonist, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Nuclear Receptor Subfamily 4, Group A, Member 1, Immunology and Allergy, Animals, Humans, PPAR delta, Colitis, Receptor, Cells, Cultured, business.industry, Macrophages, Dextran Sulfate, General Medicine, Triazoles, medicine.disease, Inflammatory Bowel Diseases, Ulcerative colitis, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Retinoid X Receptors, Cytokines, Inflammation Mediators, business, 030215 immunology, Protein Binding
Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is an intractable disease of the gastrointestinal tract. Multiple environmental factors, including food ingredients, have been implicated in the development of these diseases. For example, animal fat-rich diets are predisposing factors for ulcerative colitis, whereas n-3 unsaturated fatty acids such as docosahexaenoic acid (DHA) show protective effects in experimental colitis and are negatively correlated with the incidence of ulcerative colitis and Crohn's disease. Given that DHA exhibits agonistic activity on retinoid X receptor (RXR), activation of RXR could be a therapeutic strategy for IBD. However, conventional full RXR agonists are known to show considerable adverse effects. We therefore took advantage of a partial RXR agonist, CBt-PMN, to minimize the adverse effects, and evaluated its efficacy in dextran sodium sulfate-induced colitis. Administration of CBt-PMN efficiently ameliorated the symptoms of colitis. This effect was attributed to the down-regulation of pro-inflammatory cytokines such as Tnf and Il6 in colon-infiltrating monocytes. Down-regulation of pro-inflammatory cytokines by CBt-PMN was also evident in lipopolysaccharide-stimulated bone marrow-derived macrophages (BMDMs). Among many RXR-associated nuclear receptors, activation of peroxisome proliferator-activated receptor δ (PPARδ) and nuclear hormone receptor 77 (Nur77) suppressed cytokine production by BMDMs. These observations suggest that the activation of PPARδ/RXR and Nur77/RXR heterodimers by CBt-PMN through the permissive mechanism is responsible for diminishing the monocyte-mediated inflammatory response in the gut. Our data highlight the importance of RXR activation in the regulation of colitis.

Published
2018

18. Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Author

Nagai, Motoyoshi, primary, Noguchi, Ryotaro, additional, Takahashi, Daisuke, additional, Morikawa, Takayuki, additional, Koshida, Kouhei, additional, Komiyama, Seiga, additional, Ishihara, Narumi, additional, Yamada, Takahiro, additional, Kawamura, Yuki I., additional, Muroi, Kisara, additional, Hattori, Kouya, additional, Kobayashi, Nobuhide, additional, Fujimura, Yumiko, additional, Hirota, Masato, additional, Matsumoto, Ryohtaroh, additional, Aoki, Ryo, additional, Tamura-Nakano, Miwa, additional, Sugiyama, Machiko, additional, Katakai, Tomoya, additional, Sato, Shintaro, additional, Takubo, Keiyo, additional, Dohi, Taeko, additional, and Hase, Koji, additional

Published
2019
Full Text
View/download PDF

24. A partial agonist for retinoid X receptor mitigates experimental colitis

Author

Onuki, Masayoshi, primary, Watanabe, Masaki, additional, Ishihara, Narumi, additional, Suzuki, Koichiro, additional, Takizawa, Kei, additional, Hirota, Masato, additional, Yamada, Takahiro, additional, Egawa, Aiko, additional, Shibahara, Osamu, additional, Nishii, Midori, additional, Fujihara, Michiko, additional, Makishima, Makoto, additional, Takahashi, Daisuke, additional, Furusawa, Yukihiro, additional, Kakuta, Hiroki, additional, and Hase, Koji, additional

Published
2018
Full Text
View/download PDF

26. An Experimental Study of Fibre SuspensionFlows in Pipes using Nuclear MagneticResonance Imaging

Author

Hirota, Masato

Subjects
Fibre suspension, Teknik och teknologier, Multi-phase flow, Engineering and Technology, Nuclear magnetic resonance
Abstract

This study deals with fibre suspension flows through cylindrical pipes. Thepresent work aims at measurements of opaque flows, which are common inindustries. Nuclear magnetic resonance imaging (NMRI) and ultrasound velocimetryprofiling (UVP) were employed as non-invasive and optic-independenttools to measure the velocity profiles. As a first experiment, a paper-pulp suspensionflow through a sudden contraction and expansion was investigated.The results show the NMRI technique can be used to measure the stronglyunsteady flow such as separated regions though the MR signal is attenuateddue to the turbulence in the flow. The flow loop had however an insufficientinlet length which caused asymmetric profiles at the test section. As a secondexperiment, a flow loop which provided fully developed flows at the test sectionwas designed. After that, the velocity profiles of rayon-fibre and micro-spheresuspension flows were measured by the NMRI and the UVP independently.In principle, these two techniques measure the different velocities of the fibresuspensionflows, i.e. the velocity of the water and the fibre. In dilute suspensionflows, where the velocities of the two phases were assumed to be thesame, the velocity profiles were in good agreement. This shows the validityof the two measurement techniques. However, it should be pointed out thatthere is a limitation of the current UVP method for highly concentrated flows.The velocity profiles obtained by the UVP at high concentrations seems notto represent physics while the NMRI is not affected by the concentrations. Itis argued that the advances of the NMRI for the measurement of the highlyconcentrated flows.

Published
2013

34. Negative Electrode Properties of Sn and Si Leaf Powder for Li-ion Batteries

Author

Saito, Morihiro, Nakai, Kenta, Hagiwara, Makoto, Tasaka, Akimasa, Takenaka, Toshio, Hirota, Masato, Kamei, Akika, and Inaba, Minoru

Abstract

Two kinds of metal thin platelets (Leaf Powder, Oike Co., Ltd.) based on Sn and Si were prepared, and their charge/discharge properties were investigated as alternative negative electrode materials to graphite for Li-ion batteries. One was simple metal platelets (M-LP, thickness: 100 nm) and the other was laminated platelets with an inactive Ni layer (M/Ni/M-LP, thickness: 30/30/30 nm). For both Sn and Si platelets, the shape of thin platelets effectively relieved the stress by volume expansion and shrinkage during the alloying and de-alloying processes, and improved their charge/discharge cycleabilities. Particularly, the Si platelets suppressed their agglomeration and pulverization, and much more remained the shapes than the Sn platelets. The lamination with the inactive Ni layer further improved the cycleability, though the specific capacity decreased by its presence. The alloying and de-alloying reaction with Li+ ion was substantially smooth, which was due to a decrease in the diffusion distance of Li+ ion by using the thin platelets. As a result, the Si/Ni/Si-LP exhibited a good capability over ca. 400 mAh g-1 up to 3C rate.

Published
2010

35. A partial agonist for retinoid X receptor mitigates experimental colitis.

Author

Onuki M, Watanabe M, Ishihara N, Suzuki K, Takizawa K, Hirota M, Yamada T, Egawa A, Shibahara O, Nishii M, Fujihara M, Makishima M, Takahashi D, Furusawa Y, Kakuta H, and Hase K

Subjects
Animals, Cells, Cultured, Cytokines metabolism, Dextran Sulfate, Disease Models, Animal, Docosahexaenoic Acids metabolism, Humans, Inflammation Mediators metabolism, Lipopolysaccharides immunology, Male, Mice, Mice, Inbred C57BL, Nuclear Receptor Subfamily 4, Group A, Member 1 metabolism, PPAR delta metabolism, Protein Binding, Retinoid X Receptors agonists, Tetrahydronaphthalenes pharmacology, Triazoles pharmacology, Colitis metabolism, Inflammatory Bowel Diseases metabolism, Macrophages immunology, Retinoid X Receptors metabolism, Tetrahydronaphthalenes therapeutic use, Triazoles therapeutic use
Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is an intractable disease of the gastrointestinal tract. Multiple environmental factors, including food ingredients, have been implicated in the development of these diseases. For example, animal fat-rich diets are predisposing factors for ulcerative colitis, whereas n-3 unsaturated fatty acids such as docosahexaenoic acid (DHA) show protective effects in experimental colitis and are negatively correlated with the incidence of ulcerative colitis and Crohn's disease. Given that DHA exhibits agonistic activity on retinoid X receptor (RXR), activation of RXR could be a therapeutic strategy for IBD. However, conventional full RXR agonists are known to show considerable adverse effects. We therefore took advantage of a partial RXR agonist, CBt-PMN, to minimize the adverse effects, and evaluated its efficacy in dextran sodium sulfate-induced colitis. Administration of CBt-PMN efficiently ameliorated the symptoms of colitis. This effect was attributed to the down-regulation of pro-inflammatory cytokines such as Tnf and Il6 in colon-infiltrating monocytes. Down-regulation of pro-inflammatory cytokines by CBt-PMN was also evident in lipopolysaccharide-stimulated bone marrow-derived macrophages (BMDMs). Among many RXR-associated nuclear receptors, activation of peroxisome proliferator-activated receptor δ (PPARδ) and nuclear hormone receptor 77 (Nur77) suppressed cytokine production by BMDMs. These observations suggest that the activation of PPARδ/RXR and Nur77/RXR heterodimers by CBt-PMN through the permissive mechanism is responsible for diminishing the monocyte-mediated inflammatory response in the gut. Our data highlight the importance of RXR activation in the regulation of colitis., (© The Japanese Society for Immunology. 2018. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results