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172 results on '"Hirotsu, Takaaki"'

4. Advancing Veterinary Oncology: Next-Generation Diagnostics for Early Cancer Detection and Clinical Implementation.

Author

Alshammari, Aya Hasan, Oshiro, Takuya, Ungkulpasvich, Umbhorn, Yamaguchi, Junichi, Morishita, Masayo, Khdair, Sura Abbas, Hatakeyama, Hideyuki, Hirotsu, Takaaki, and di Luccio, Eric

Subjects
CIRCULATING tumor DNA, TUMOR genetics, VETERINARY medicine, EARLY detection of cancer, TUMOR markers, PETS, CAENORHABDITIS elegans
Abstract

Simple Summary: Cancer is a serious problem for dogs and cats, often diagnosed when it is already advanced and more difficult to treat. This article reviews new ways to find cancer earlier in pets, so they have a better chance of successful treatment. These methods include special scanning techniques powered by computer-based image analysis, blood tests that look for cancer markers without surgery, new ways to examine DNA or other molecules from tumors, and even a simple worm-based test to detect changes linked to cancer. By catching the disease sooner, veterinarians can suggest treatments that are more targeted and less invasive, helping pets live longer and with a higher quality of life. Because cancers in animals and humans share many features, these discoveries can guide research for both species. The goal is to make advanced cancer testing available and affordable in more clinics, leading to earlier detection and better outcomes. Ultimately, this work benefits families, pets, and the broader scientific community. Cancer is a leading cause of death among companion animals, with many cases diagnosed at advanced stages when clinical signs have appeared, and prognosis is poor. Emerging diagnostic technologies, including Artificial Intelligence (AI)-enhanced imaging, liquid biopsies, molecular diagnostics, and nematode-based screening, can improve early detection capabilities in veterinary medicine. These tools offer non-invasive or minimally invasive methods to facilitate earlier detection and treatment planning, addressing the limitations of traditional diagnostics, such as radiography and tissue biopsies. Recent advancements in comparative oncology, which leverage the biological similarities between human and companion animal cancers, underscore their translational value in improving outcomes across species. Technological advances in genomics, bioinformatics, and machine learning are driving a shift toward precision medicine, enabling earlier detection, personalized treatments, and monitoring of disease progression. Liquid biopsy testing detects circulating tumor DNA and tumor cells, providing actionable insights into tumor genetics without invasive procedures. Imaging systems enhance diagnostic precision, offering consistent and accurate tumor identification across veterinary practices, while portable innovations like Caenorhabditis elegans-based screening provide accessible options for underserved regions. As these technologies migrate from human medicine to veterinary applications, they are poised to redefine cancer care for companion animals. This review highlights key advancements in diagnostic technologies and their application in veterinary oncology, with a focus on enhancing early detection, accessibility, and precision in cancer care. By fostering the adoption of these innovations, veterinary oncology can achieve a new standard of care, improving outcomes for both animals and humans through the lens of comparative oncology. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Non-Invasive Detection of Tumors by Volatile Organic Compounds in Urine.

Author

Hara, Tomoaki, Meng, Sikun, Arao, Yasuko, Saito, Yoshiko, Inoue, Kana, Alshammari, Aya Hasan, Hatakeyama, Hideyuki, di Luccio, Eric, Vecchione, Andrea, Hirotsu, Takaaki, and Ishii, Hideshi

Subjects
OLFACTORY receptors, VOLATILE organic compounds, TUMOR markers, BLOOD testing, CAUSES of death
Abstract

Cancer is one of the major causes of death, and as it becomes more malignant, it becomes an intractable disease that is difficult to cure completely. Therefore, early detection is important to increase the survival rate. For this reason, testing with blood biomarkers is currently common. However, in order to accurately diagnose early-stage cancer, new biomarkers and diagnostic methods that enable highly accurate diagnosis are needed. This review summarizes recent studies on cancer biomarker detection. In particular, we focus on the analysis of volatile organic compounds (VOCs) in urine and the development of diagnostic methods using olfactory receptors in living organisms. Urinary samples from cancer patients contain a wide variety of VOCs, and the identification of cancer specific compounds is underway. It has also been found that the olfactory sense of organisms can distinguish cancer-specific odors, which may be applicable to cancer diagnosis. We explore the possibility of novel cancer biomarker candidates and novel diagnostic methods. [ABSTRACT FROM AUTHOR]

Published
2025
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6. Overcoming Challenges in Cancer Care: A Focus on Emerging Technologies.

Author

Alshammari, Aya Hasan, Hirotsu, Takaaki, and di Luccio, Eric

Subjects
MOLECULAR biology, COMPUTATIONAL biology, T-cell exhaustion, MYELOID-derived suppressor cells, LIFE sciences
Abstract

The editorial from the journal "Biomedicines" discusses the advancements in cancer research, focusing on emerging technologies to address challenges in cancer care. It highlights innovative therapeutic strategies, diagnostic tools, immune modulation, and precision oncology. The text emphasizes the importance of interdisciplinary collaboration, global health policy reforms, and patient-centered solutions to improve cancer outcomes worldwide. The document underscores the transformative potential of these technologies but acknowledges the need to overcome barriers such as resistance mechanisms, accessibility, and affordability to ensure equitable access to advanced treatments. [Extracted from the article]

Published
2024
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8. Tissue-Resident Memory T Cells in Gastrointestinal Cancers: Prognostic Significance and Therapeutic Implications.

Author

Sato, Hiromichi, Meng, Sikun, Hara, Tomoaki, Tsuji, Yoshiko, Arao, Yasuko, Sasaki, Kazuki, Kobayashi, Shogo, di Luccio, Eric, Hirotsu, Takaaki, Satoh, Taroh, Doki, Yuichiro, Eguchi, Hidetoshi, and Ishii, Hideshi

Subjects
IMMUNOLOGIC memory, GASTROINTESTINAL cancer, PROGNOSIS, IMMUNE checkpoint inhibitors, TREATMENT effectiveness
Abstract

Gastrointestinal cancers, which include a variety of esophageal and colorectal malignancies, present a global health challenge and require effective treatment strategies. In the evolving field of cancer immunotherapy, tissue-resident memory T cells (Trm cells) have emerged as important players in the immune response within nonlymphoid tissues. In this review, we summarize the characteristics and functions of Trm cells and discuss their profound implications for patient outcomes in gastrointestinal cancers. Positioned strategically in peripheral tissues, Trm cells have functions beyond immune surveillance, affecting tumor progression, prognosis, and response to immunotherapy. Studies indicate that Trm cells are prognostic markers and correlate positively with enhanced survival. Their presence in the tumor microenvironment has sparked interest in their therapeutic potential, particularly with respect to immune checkpoint inhibitors, which may improve cancer treatment. Understanding how Trm cells work will not only help to prevent cancer spread through effective treatment but will also contribute to disease prevention at early stages as well as vaccine development. The role of Trm cells goes beyond just cancer, and they have potential applications in infectious and autoimmune diseases. This review provides a thorough analysis of Trm cells in gastrointestinal cancers, which may lead to personalized and effective cancer therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Contributors

Author

Asai, Ayumu, primary, Gao, Lingyue, additional, Hirotsu, Takaaki, additional, Ishii, Hideshi, additional, Konno, Masamitsu, additional, Liu, Shini, additional, Lu, Sixiao, additional, Shan, Changliang, additional, Shen, Ao, additional, Song, Jiaqi, additional, Sun, Huanran, additional, Sun, Mingming, additional, Tan, Jing, additional, Wang, Haiwen, additional, Wang, Lihui, additional, Wen, Shijun, additional, Wu, Chunfu, additional, Yang, Cheng, additional, Yu, Xi-Yong, additional, and Zhang, Jiayu, additional

Published
2021
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14. Clinical Possibility of Caenorhabditis elegans as a Novel Evaluation Tool for Esophageal Cancer Patients Receiving Chemotherapy: A Prospective Study

Author

Sato, Yuta, primary, Futamura, Manabu, additional, Tanaka, Yoshihiro, additional, Tsuchiya, Hiroshi, additional, Fukada, Masahiro, additional, Higashi, Toshiya, additional, Yasufuku, Itaru, additional, Asai, Ryuichi, additional, Tajima, Jesse Yu, additional, Kiyama, Shigeru, additional, Hatakeyama, Hideyuki, additional, Morishita, Masayo, additional, Hirotsu, Takaaki, additional, Luccio, Eric di, additional, Ishihara, Takuma, additional, Matsuhashi, Nobuhisa, additional, and Yoshida, Kazuhiro, additional

Published
2023
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16. m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection

Author

Sato, Hiromichi, primary, Hara, Tomoaki, additional, Otsuka, Chihiro, additional, Arao, Yasuko, additional, Tsuji, Yoshiko, additional, Hamano, Yumiko, additional, Ogita, Mirei, additional, di Luccio, Eric, additional, Hirotsu, Takaaki, additional, Vecchione, Andrea, additional, and Ishii, Hideshi, additional

Published
2023
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17. Pancreatic Cancer Research beyond DNA Mutations

Author

Sato, Hiromichi, primary, Sasaki, Kazuki, additional, Hara, Tomoaki, additional, Tsuji, Yoshiko, additional, Arao, Yasuko, additional, Otsuka, Chihiro, additional, Hamano, Yumiko, additional, Ogita, Mirei, additional, Kobayashi, Shogo, additional, di Luccio, Eric, additional, Hirotsu, Takaaki, additional, Doki, Yuichiro, additional, Eguchi, Hidetoshi, additional, Satoh, Taroh, additional, Uchida, Shizuka, additional, and Ishii, Hideshi, additional

Published
2022
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28. MO23-1 Detection of hematological malignancies using N-NOSE (Nematode-NOSE)

Author

Nakamura, Shingen, primary, Ueno, Yoshihisa, additional, Yoshida, Sumiko, additional, Nakamura, Masafumi, additional, Mizuguchi, Makiko, additional, Sumitani, Ryohei, additional, Oura, Masahiro, additional, Sogabe, Kimiko, additional, Takahashi, Mamiko, additional, Maruhashi, Tomoko, additional, Harada, Takeshi, additional, Fujii, Shiro, additional, Miki, Hirokazu, additional, Kagawa, Kumiko, additional, Hirotsu, Takaaki, additional, and Abe, Masahiro, additional

Published
2021
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30. Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes

Author

Takeda, Yu, primary, Kobayashi, Shogo, additional, Kitakaze, Masatoshi, additional, Yamada, Daisaku, additional, Akita, Hirofumi, additional, Asai, Ayumu, additional, Konno, Masamitsu, additional, Arai, Takahiro, additional, Kitagawa, Toru, additional, Ofusa, Ken, additional, Yabumoto, Masami, additional, Hirotsu, Takaaki, additional, Vecchione, Andrea, additional, Taniguchi, Masateru, additional, Doki, Yuichiro, additional, Eguchi, Hidetoshi, additional, and Ishii, Hideshi, additional

Published
2020
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32. COVID-19 Drug Discovery Using Intensive Approaches

Author

Asai, Ayumu, primary, Konno, Masamitsu, additional, Ozaki, Miyuki, additional, Otsuka, Chihiro, additional, Vecchione, Andrea, additional, Arai, Takahiro, additional, Kitagawa, Toru, additional, Ofusa, Ken, additional, Yabumoto, Masami, additional, Hirotsu, Takaaki, additional, Taniguchi, Masateru, additional, Eguchi, Hidetoshi, additional, Doki, Yuichiro, additional, and Ishii, Hideshi, additional

Published
2020
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33. The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans

Author

Hirotsu, Takaaki, Saeki, Satoshi, Yamamoto, Masayuki, and Iino, Yuichi

Abstract

Author(s): Takaaki Hirotsu; Satoshi Saeki [1, 2]; Masayuki Yamamoto [1]; Yuichi Iino (corresponding author) The Ras-MAPK (mitogen-activated protein kinase) signal transduction pathway is well known to control cellular proliferation and [...]

Published
2000
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35. A non-invasive screening method using Caenorhabditis elegansfor early detection of multiple cancer types: A prospective clinical study

Author

Hatakeyama, Hideyuki, Morishita, Masayo, Alshammari, Aya Hasan, Ungkulpasvich, Umbhorn, Yamaguchi, Junichi, Hirotsu, Takaaki, and di Luccio, Eric

Abstract

Cancer is the second leading cause of death worldwide, according to the World Health Organization, surpassed only by cardiovascular diseases. Early identification and intervention can significantly improve outcomes. However, finding a universal, non-invasive, economical, and precise method for early cancer detection remains a significant challenge. This study explores the efficacy of an innovative cancer detection test, N-NOSE, leveraging a Caenorhabditis elegansolfactory assay on urine samples across a diverse patient group exceeding 1600 individuals diagnosed with various cancers, with samples from the Shikoku Cancer Center (Ehime, Japan) under approved ethical standards. Current cancer screening techniques often require invasive procedures, can be painful or complex, with poor performance, and might be prohibitively costly, limiting accessibility for many. N-NOSE addresses these challenges head-on by offering a test based on urine analysis, eliminating the need for invasive methods, and being more affordable with higher performance at early stages than extensive blood tests or comprehensive body scans for cancer detection. In this study, N-NOSE demonstrated a capability to accurately identify upwards of 20 cancer types, achieving detection sensitivities between 60 and 90 %, including initial-stage cancers. The findings robustly advocate for N-NOSE's potential as a revolutionary, cost-effective, and minimally invasive strategy for broad-spectrum early cancer detection. It is also particularly significant in low- and middle-income countries with limited access to advanced cancer diagnostic methods, which may contribute to the improved outcome of affected individuals.

Published
2024
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36. Revised_SupplementaryInformation_4_xyz2778816687648 – Supplemental material for Behavioural Response Alteration in Caenorhabditis elegans to Urine After Surgical Removal of Cancer: Nematode-NOSE (N-NOSE) for Postoperative Evaluation

Author

Hirotake Kusumoto, Tashiro, Kotaro, Syunji Shimaoka, Tsukasa, Koichiro, Baba, Yukiko, Furukawa, Saori, Furukawa, Junichiro, Toyokuni Suenaga, Kitazono, Masaki, Tanaka, Sadao, Niihara, Toru, Hirotsu, Takaaki, and Uozumi, Takayuki

Subjects
Cell Biology
Abstract

Supplemental material, Revised_SupplementaryInformation_4_xyz2778816687648 for Behavioural Response Alteration in Caenorhabditis elegans to Urine After Surgical Removal of Cancer: Nematode-NOSE (N-NOSE) for Postoperative Evaluation by Hirotake Kusumoto, Kotaro Tashiro, Syunji Shimaoka, Koichiro Tsukasa, Yukiko Baba, Saori Furukawa, Junichiro Furukawa, Toyokuni Suenaga, Masaki Kitazono, Sadao Tanaka, Toru Niihara, Takaaki Hirotsu and Takayuki Uozumi in Biomarkers in Cancer

Published
2019
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41. Rehabilitation Risk Management Strategies in Relation to Prescribed Medications

Author

NANBA, Yoshifumi, primary, HIROTSU, Takaaki, additional, HIDANI, Arisa, additional, TANAKA, Minoru, additional, FUJIE, Ryousuke, additional, INATA, Natsumi, additional, MATSUURA, Akihiro, additional, NAKASO, Naoyuki, additional, KONDO, Yoshihiro, additional, MATSUURA, Yuji, additional, ITAGAKI, Yousuke, additional, NAGASE, Takahiro, additional, and MIZUTA, Yuki, additional

Published
2019
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42. Behavioural Response Alteration inCaenorhabditis elegansto Urine After Surgical Removal of Cancer: Nematode-NOSE (N-NOSE) for Postoperative Evaluation

Author

Kusumoto, Hirotake, primary, Tashiro, Kotaro, additional, Shimaoka, Syunji, additional, Tsukasa, Koichiro, additional, Baba, Yukiko, additional, Furukawa, Saori, additional, Furukawa, Junichiro, additional, Suenaga, Toyokuni, additional, Kitazono, Masaki, additional, Tanaka, Sadao, additional, Niihara, Toru, additional, Hirotsu, Takaaki, additional, and Uozumi, Takayuki, additional

Published
2019
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50. Retraction: Effect of exercise at light loads with manipulative resistance on infraspinatus, trapezius (upper fiber) and deltoid (middle fiber) muscle activities in shoulder joint elevation

Author

Nanba, Yoshifumi, primary, Miyamoto, Shigenori, additional, Takemasa, Seiichi, additional, Uesugi, Masayuki, additional, Inoue, Yuri, additional, Ootani, Yoshitaka, additional, Fujii, Shun, additional, Hirotsu, Takaaki, additional, and Tanaka, Hideki, additional

Published
2015
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