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1. Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids

Author

Gerli, Mattia Francesco Maria, Calà, Giuseppe, Beesley, Max Arran, Sina, Beatrice, Tullie, Lucinda, Sun, Kylin Yunyan, Panariello, Francesco, Michielin, Federica, Davidson, Joseph R., Russo, Francesca Maria, Jones, Brendan C., Lee, Dani Do Hyang, Savvidis, Savvas, Xenakis, Theodoros, Simcock, Ian C., Straatman-Iwanowska, Anna A., Hirst, Robert A., David, Anna L., O’Callaghan, Christopher, Olivo, Alessandro, Eaton, Simon, Loukogeorgakis, Stavros P., Cacchiarelli, Davide, Deprest, Jan, Li, Vivian S. W., Giobbe, Giovanni Giuseppe, and De Coppi, Paolo

Published
2024
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3. Journal update monthly top five

Author

Prager, Gabrielle, primary, Hirst, Robert, additional, Darbyshire, Daniel, additional, Van Den Berg, Patricia, additional, Oliver, Govind, additional, Shanahan, Thomas Alexander Gerrard, additional, and Carley, Simon David, additional

Published
2024
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6. Evaluating gene-disease relationships in motile ciliopathies: an international ClinGen and BEAT-PCD ERS CRC collaboration.

Author

Crowley, Suzanne, primary, Hankey, William, additional, Elnagheeb, Marwa, additional, Mani, Rahma, additional, Benito, Maria-Ines, additional, Soliman, Rasha, additional, De Almeida Gomes, Mafalda, additional, Ing, Alexander, additional, Abdelwahab, Sabri, additional, Worley, Lindsay, additional, Mcnulty, Shannon, additional, Siew, Justine, additional, Thaxton, Courtney Lynn, additional, Loucks, Catrina M, additional, Thomas, Simon, additional, Zariwala, Maimoona, additional, Leigh, Margaret, additional, Morris-Rosendahl, Deborah, additional, Ziętkiewicz, Ewa, additional, Dell, Sharon, additional, Gaston, Ben, additional, Dworniczak, Bernd, additional, Hirst, Robert, additional, Raidt, Johanna, additional, Nykamp, Keith, additional, Hannah, William, additional, Fassad, Mahmoud, additional, Shoemark, Amelia, additional, Legendre, Marie, additional, and Mitchison, Hannah, additional

Published
2023
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7. Journal update monthly top five

Author

Akrama, Osama, primary, Armstrong, Luke, additional, Desai, Moudgalya Kumar, additional, Horner Le Riche, Alison, additional, Keating, Liza, additional, Knowles, Charlotte, additional, Perera, Yanithra, additional, Porter, Thomas, additional, and Hirst, Robert, additional

Published
2023
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8. Axonemal structures reveal mechanoregulatory and disease mechanisms

Author

Walton, Travis, primary, Gui, Miao, additional, Velkova, Simona, additional, Fassad, Mahmoud R., additional, Hirst, Robert A., additional, Haarman, Eric, additional, O’Callaghan, Christopher, additional, Bottier, Mathieu, additional, Burgoyne, Thomas, additional, Mitchison, Hannah M., additional, and Brown, Alan, additional

Published
2023
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9. Update on primary ciliary dyskinesia

Author

Robson, Evie Alexandra, Chetcuti, Philip, Hirst, Robert Anthony, Mitchison, Hannah, Moya, Eduardo, Peckham, Daniel, Robinson, Philip J., Rutman, Andrew, and O'Callaghan, Christopher

Published
2017
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10. Proceedings of the 4th BEAT-PCD Conference and 5th PCD Training School

Author

Gardner, Laura E., Horton, Katie L., Shoemark, Amelia, Lucas, Jane S., Nielsen, Kim G., Kobbernagel, Helene, Rubbo, Bruna, Hirst, Robert A., Kouis, Panayiotis, Ullmann, Nicola, Reula, Ana, Rumman, Nisreen, Mitchison, Hannah M., Pinto, Andreia, Richardson, Charlotte, Schmidt, Anne, Thompson, James, Gaupmann, René, Dabrowski, Maciej, Mill, Pleasantine, Carr, Siobhan B., Norris, Dominic P., Kuehni, Claudia E., Goutaki, Myrofora, and Hogg, Claire

Published
2020
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12. The network dependency of religious and secular belief

Author

Hirst, Robert W.

Subjects
100, Modernity, Social networks, Ego centred
Abstract

This thesis develops and tests a social network theory of religion to explain the phenomena of religious and secular beliefs in the general population in contemporary Britain. Drawing upon the writings of several historians and upon the work of Giddens (1994a, 1994b), the study is placed in the theoretical context of the debate about the nature of modernity. Due to the various processes of modernization it is argued that personal network links between church attenders and non-church attenders have gradually been severed since pre-modern times. The immediate consequences of this development are twofold. First, the transmission of church religion is greatly restricted. Second, personal overarching religious, or indeed secular, world views are now likely to be formulated, maintained, modified and transmitted by individuals within discrete and geographically dispersed social networks within the private sphere. On the basis of this argument a network dependency hypothesis was formulated, from which twenty-two testable propositions were derived. By employing ego-centred network analysis, the empirical dimension of this thesis reports the testing of each of these propositions against data obtained from a quantitative 500 questionnaire survey of a middle class suburb in the south of England, followed by 39 qualitative focused interviews with informants selected from the initial survey. The data showed that responses to the process of primary socialization had a profound effect on the initial belief formation of ego. This provided a foundation both for religious or secular belief in later life and for the future selection of network alters. With the exception of conversionists, these beliefs generally continued to be maintained by ego within ego's current network. At all stages ego demonstrated a need to reduce cognitive dissonance and to pursue cognitive consonance (Festinger, 1985). The local community did not constitute a plausibility structure and even the local church did not perform this function. Only discrete, dispersed, personal networks in the private sphere functioned to maintain the plausibility of religious and secular beliefs. The findings constituted overwhelming support for the network dependency hypothesis.

Published
1999

17. Studies on the coupling of opioid and cannabinoid receptors to adenylyl cyclase

Author

Hirst, Robert Anthony

Subjects
572
Abstract

This thesis represents a detailed study of the regulation of adenylyl cyclase (AC) by opioid and cannabinoid ligands which act at transmembrane spanning Gi-protein coupled receptors.;In SH-SY5Y human neuroblastoma cells carbachol (CCh) and K+ caused a time and dose dependent increase in cAMP formation and also increased [Ca2+]i. Ni2+ essentially abolished CCh stimulated [Ca2+]i plateau phase and blocked K+ stimulated [Ca2+]i. Preincubation with Ni2+, did not affect the initial CCh mediated rise in cAMP but significantly reduced the 5 and l0min levels. CCh in Ca2+ free buffer increased cAMP and when Ca2+ was re-introduced to the buffer there was a further increase in cAMP. These studies suggest that SH-SY5Y cells express type 1 AC.;The previously characterised SH-SY5Y ([3H]Diprenorphine (DPN) Bmax (an estimate of opioid receptor density)=98fmol/mg protein) and NG108-15 ([3H]DPN Bmax=280fmol/mg protein) cells were used as a model system for the study of endogenous mu- and delta- opioid receptors respectively. In SH-SY5Y membranes, fentanyl, DAMGO and in NG108-15 membranes, DPDPE, DADLE displaced [3H]DPN revealing high affinity binding sites. Fentanyl, DAMGO (SH-SY5Y) and DPDPE, DADLE (NG108-15) dose dependency inhibited forskolin stimulated cAMP formation with IC50 values of 18, 202nM and 0.8, 0.5nM respectively. Maximal inhibition (Imax) in both cell lines with all agonists were relatively constant, 47-65%. The ORL-1 receptor agonist, nociceptin also inhibited forskolin stimulated cAMP formation in SHSY5Y cells with IC50 and Imax values of 72nM and 47% respectively. These studies in SH-SY5Y cells, report the regulation by opioid and OR1-1 receptors of type 1 AC.;Endogenous opioid receptors in SH-SY5Y and NG108-15 cells were then compared with recombinant receptors expressed in CHO cells. Opioid receptor subtypes (mu-, delta-, and kappa-) bound [3H]DPN in a dose dependent and saturable manner, (Bmax, range=35- 561fmol/mc protein). Fentanyl and [D-Ala 2,Me-Phe4,Gly-ol]enkephalin (DAMGO) displaced [ H]DPN from CHOmu membranes with high affinity. Spiradoline displaced [ 3H]DPN from CHOkappa cells. [D-Pen2,D-pen 5]enkephalin (DPDPE) and [D-Ala2,DLeu5] enkephalin (DADLE) displaced [3H]DPN from CHOdelta cell membranes revealing the presence of a high affinity binding site. All opioid agonists used in displacement studies inhibited forskolin stimulated cAMP formation in there respective CHOmu, delta, or kappa cells.;The cannabinoid receptor is also an example of a transmembrane spanning G-protein coupled receptor. In order to study the cannabinoid receptor in detail, an assay was developed using the first central cannabinoid receptor (CB1) selective antagonist, SR141716A. In rat cerebella membranes, [ 3H]SR141716A bound with a Kd of around 0.7nM. A range of cannabinoid agonists displaced [3H]SR141716A from cerebella membranes. In addition, basal cAMP levels were inhibited by WIN55212-2 in rat cerebella membranes in an SR141716A reversible manner.;CB1 cDNA was expressed in CHO cells and the resulting CHOCB1 cells bound [3H]S R M H lbA , which was displaced dose dependently by unlabeled SR141716A yielding a Ki of 2.2nM. These receptors were functionally coupled to adenylyl cyclase. Collectively, these findings add significantly to our current understanding of opioid and cannabinoid receptor regulation of AC.

Published
1997

18. Journal update monthly top five

Author

Hirst, Robert, primary, Courtney, Hannah, additional, Grossi, Irene, additional, Hill, Catherine, additional, Maidwell-Smith, Alexander T, additional, and Stuart, Edward, additional

Published
2022
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19. TUBB4Bvariants specifically impact ciliary function, causing a ciliopathic spectrum

Author

Mechaussier, Sabrina, Dodd, Daniel O, Yeyati, Patricia L, McPhie, Fraser, Attard, Thomas, Shoemark, Amelia, Gupta, Deepesh K, Zariwala, Maimoona A, Legendre, Marie, Bracht, Diana, Wallmeier, Julia, Gui, Miao, Anderson, Jacob R, Fassad, Mahmoud R, Parry, David A, Tennant, Peter A, Meynert, Alison, Wheway, Gabrielle, Fares-Taie, Lucas, Black, Holly A, Mitri-Frangieh, Rana, Faucon, Catherine, Kaplan, Josseline, Patel, Mitali, McKie, Lisa, Megaw, Roly, Gatsogiannis, Christos, Mohamed, Mai A, Aitken, Stuart, Gautier, Philippe, Reinholt, Finn R, Hirst, Robert A, O’Callaghan, Chris, Heimdal, Ketil, Bottier, Mathieu, Escudier, Estelle, Crowley, Suzanne, Descartes, Maria, Jabs, Ethylin W, Kenia, Priti, Amiel, Jeanne, Blümlein, Ulrike, Rogers, Andrew, Wambach, Jennifer A, Wegner, Daniel J, Fulton, Anne B, Kenna, Margaret, Rosenfeld, Margaret, Holm, Ingrid A, Quigley, Alan, Cassidy, Diana M, von Kriegsheim, Alex, Papon, Jean-Francois, Pasquier, Laurent, Murris, Marlène S, Chalmers, James D, Hogg, Clare, Macleod, Kenneth, Urquhart, Don S, Unger, Stefan, Aitman, Timothy J, Amselem, Serge, Rozet, Jean-Michel, Leigh, Margaret W, Knowles, Michael R., Omran, Heymut, Mitchison, Hannah M, Brown, Alan, Marsh, Joseph A, Welburn, Julie P I, Horani, Amjad, Perrault, Isabelle, and Mill, Pleasantine

Abstract

Cilia are small microtubule-based structures found on the surface of most mammalian cells, which have key sensory and sometimes motile functions. Primary ciliary dyskinesia (PCD) is a type of ciliopathy caused by defects in motile cilia. The genetic basis of PCD is only partially understood. Studying a cohort of 11 human patients with PCD, we find thatde novomutations inTUBB4B, a beta tubulin isotype, cause three distinct classes of ciliopathic disease.In vivostudies in mice show thatTubb4bplays a specific role in cilia, building centrioles and axonemes in multiciliated cells. Examining the effects of specific TUBB4B variants in cells and in mice, we further demonstrate that distinctTUBB4Bmutations differentially affect microtubule dynamics and cilia formation in a dominant negative manner. Finally, structure-function studies reveal that different TUBB4B mutations disrupt distinct tubulin interfaces. Importantly, these molecular differences correlate with disease features. We show that tubulin heterodimer-impairing TUBB4B variants underlie nonsyndromic PCD, whilst additional renal and sensorineural ciliopathic features in a syndromic PCD subtype arise from microtubule lumenal interface-impaired TUBB4B variants. These findings suggest that specific tubulin isotypes have distinct and non-redundant subcellular functions, and demonstrate that human tubulinopathies can be drivers of ciliopathic syndromes.

Published
2022

21. Journal update monthly top five

Author

Shanahan, Thomas Alexander Gerrard, primary, Cottey, Laura, additional, Darbyshire, Daniel, additional, Hirst, Robert, additional, Naquib, Mina, additional, Oliver, Govind, additional, and Prager, Gabrielle, additional

Published
2022
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22. High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations

Author

Shoemark, Amelia, Moya, Eduardo, Hirst, Robert A, Patel, Mitali P, Robson, Evelyn A, Hayward, Jane, Scully, Juliet, Fassad, Mahmoud R, Lamb, William, Schmidts, Miriam, Dixon, Mellisa, Patel-King, Ramila S, Rogers, Andrew V, Rutman, Andrew, Jackson, Claire L, Goggin, Patricia, Rubbo, Bruna, Ollosson, Sarah, Carr, Siobhán, Walker, Woolf, Adler, Beryl, Loebinger, Michael R, Wilson, Robert, Bush, Andrew, Williams, Hywel, Boustred, Christopher, Jenkins, Lucy, Sheridan, Eamonn, Chung, Eddie M K, Watson, Christopher M, Cullup, Thomas, Lucas, Jane S, Kenia, Priti, OʼCallaghan, Christopher, King, Stephen M, Hogg, Claire, and Mitchison, Hannah M

Published
2018
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27. Proceedings of the 2nd BEAT-PCD conference and 3rd PCD training school: part 1

Author

Halbeisen, Florian, Hogg, Claire, Alanin, Mikkel C., Bukowy-Bieryllo, Zuzanna, Dasi, Francisco, Duncan, Julie, Friend, Amanda, Goutaki, Myrofora, Jackson, Claire, Keenan, Victoria, Harris, Amanda, Hirst, Robert A., Latzin, Philipp, Marsh, Gemma, Nielsen, Kim, Norris, Dominic, Pellicer, Daniel, Reula, Ana, Rubbo, Bruna, Rumman, Nisreen, Shoemark, Amelia, Walker, Woolf T., Kuehni, Claudia E., and Lucas, Jane S.

Published
2018
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28. Journal update monthly top five

Author

Saxena, Monica, primary, Altamirano, Jonathan, additional, Rose, Christian, additional, Bennett, Christopher, additional, Govindarajan, Prasha, additional, Lumba-Brown, Angela, additional, and Hirst, Robert, additional

Published
2022
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29. Journal update monthly top five

Author

Chatha, Rajesh, primary, Anderson, Rory, additional, Chatha, Hridesh, additional, Cocker, Lucyna Mabel, additional, Connelly, Michael, additional, Ward, Catherine, additional, and Hirst, Robert, additional

Published
2022
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36. The COVID-19 emergency response assessment study: a prospective longitudinal survey of frontline doctors in the UK and Ireland

Author

Roberts, Tom, Daniels, Jo, Hulme, William, Hirst, Robert, Horner, Daniel, Lyttle, Mark David, Samuel, Katie, Graham, Blair, Reynard, Charles, Barrett, Michael, Foley, James, Cronin, John, Umana, Etimbuk, Vinagre, Joao, and Carlton, Edward

Subjects
trauma, Emergency department, distress
Abstract

Objectives The psychological impact of the COVID-19 pandemic on doctors is a significant concern. Due to the emergence of multiple pandemic waves, longitudinal data on the impact of COVID-19 are vital to ensure an adequate psychological care response. The primary aim was to assess the prevalence and degree of psychological distress and trauma in frontline doctors during the acceleration, peak and deceleration of the COVID-19 first wave. Personal and professional factors associated with psychological distress are also reported.Design A prospective online three-part longitudinal survey.Setting Acute hospitals in the UK and Ireland.Participants Frontline doctors working in emergency medicine, anaesthetics and intensive care medicine during the first wave of the COVID-19 pandemic in March 2020.Primary outcome measures Psychological distress and trauma measured using the General Health Questionnaire-12 and the Impact of Events-Revised.Results The initial acceleration survey distributed across networks generated a sample of 5440 doctors. Peak and deceleration response rates from the original sample were 71.6% (n=3896) and 56.6% (n=3079), respectively. Prevalence of psychological distress was 44.7% (n=1334) during the acceleration, 36.9% (n=1098) at peak and 31.5% (n=918) at the deceleration phase. The prevalence of trauma was 23.7% (n=647) at peak and 17.7% (n=484) at deceleration. The prevalence of probable post-traumatic stress disorder was 12.6% (n=343) at peak and 10.1% (n=276) at deceleration. Worry of family infection due to clinical work was the factor most strongly associated with both distress (R2=0.06) and trauma (R2=0.10).Conclusion Findings reflect a pattern of elevated distress at acceleration and peak, with some natural recovery. It is essential that policymakers seek to prevent future adverse effects through (a) provision of vital equipment to mitigate physical and psychological harm, (b) increased awareness and recognition of signs of psychological distress and (c) the development of clear pathways to effective psychological care.

Published
2021

37. Psychological distress and trauma during the COVID-19 pandemic: survey of doctors practising anaesthesia, intensive care medicine, and emergency medicine in the United Kingdom and Republic of Ireland

Author

Kane, L., Mackenzie, L., Sharma Hajela, S., Phizacklea, J., Malik, K., Mathai, N., Sattout, A., Messahel, S., Fadden, E., McQuillan, R., O'Hare, B., Lewis, S., Bewick, D., Taylor, R., Hancock, I., Manthalapo Ramesh Babu, D., Hartshorn, S., Williams, M., Charlton, A., Somerset, L., Munday, C., Turner, A., Sainsbury, R., Williams, E., Patil, S., Stewart, R., Winstanley, M., Tambe, N., Magee, C., Raffo, D., Mawhinney, D., Taylor, B., Hussan, T., Pells, G., Barham, F., Wood, F., Szekeres, C., Greenhalgh, R., Marimuthu, S., Macfarlane, R., Alex, M., Shrestha, B., Stanley, L., Gumley, J., Thomas, K., Anderson, M., Weegenaar, C., Lockwood, J., Mohamed, T., Ramraj, S., Mackenzie, M., Robertson, A., Niven, W., Patel, M., Subramaniam, S., Holmes, C., Bongale, S., Bait, U., Nagendran, S., Rao, S., Mendes, F., Singh, P., Baron, T., Ponmani, C., Depante, M., Sneep, R., Brookes, A., Williams, S., Rainey, A., Brown, J., Marriage, N., Manou, S., Hart, S., Elsheikh, M., Cocker, L., Elwan, M.H., Vincent, K.L., Nunn, C., Sarja, N., Viegas, M., Wooffinden, E., Reynard, C., Cherian, N., Da-Costa, A., Duckitt, S., Bailey, J., How, L., Hine, T., Ihsan, F., Abdullah, H., Bader, K., Pradhan, S., Manoharan, M., Kehler, L., Muswell, R., Bonsano, M., Evans, J., Christmas, E., Knight, K., O'Rourke, L., Adeboye, K., Iftikhar, K., Evans, R., Darke, R., Freeman, R., Grocholski, E., Kaur, K., Cooper, H., Mohammad, M., Harwood, L., Lines, K., Thomas, C., Ranasinghe, D., Hall, S., Wright, J., Ali, N., Hunt, J., Ahmad, H., Ward, C., Khan, M., Holzman, K., Ritchie, J., Hormis, A., Hannah, R., Corfield, A., Maney, J., Metcalfe, D., Timmis, S., Williams, C., Newport, R., Bawden, D., Tabner, A., Malik, H., Roe, C., McConnell, D., Taylor, F., Ellis, R., Morgan, S., Barnicott, L., Foster, S., Browning, J., McCrae, L., Godden, E., Saunders, A., Lawrence-Ball, A., House, R., Muller, J., Skene, I., Lim, M., Millar, H., Rai, A., Challen, K., Currie, S., Elkanzi, M., Perry, T., Kan, W., Brown, L., Cheema, M., Clarey, A., Gulati, A., Webster, K., Howson, A., Doonan, R., Trimble, A., O’Connell, C., Wright, R., Colley, E., Rimmer, C., Pintus, S., Jarman, H., Worsnop, V., Collins, S., Colmar, M., Masood, N., McLatchie, R., Peasley, A., Rahman, S., Mullen, N., Armstrong, L., Hay, A., Mills, R., Lowe, J., Raybould, H., Ali, A., Cuthbert, P., Taylor, S., Talwar, V., Al-Janabi, Z., Leech, C., Turner, J., McKechnie, L., Mallon, B., McLaren, J., Moulds, Y., Dunlop, L., Burton, F.M., Keers, S., Robertson, L., Craver, D., Moultrie, N., Williams, O., Purvis, S., Clark, M., Davies, C., Foreman, S., Ngua, C., Morgan, J., Hoskins, N., Fryer, J., Frost, L., Ellis, P., Mackay, A., Gray, K., Jacobs, M., Musliam Veettil Asif, I., Amiri, P., Shrivastava, S., Raza, F., Wilson, S., Riyat, M., Knott, H., Ramazany, M., Langston, S., Abela, N., Robinson, L., Maasdorp, D., Murphy, H., Edmundson, H., Das, R., Orjioke, C., Worley, D., Collier, W., Everson, J., Maleki, N., Stafford, A., Gokani, S., Charalambos, M., Olajide, A., Bi, C., Ng, J., Naeem, S., Hill, A., Boulind, C., O'Sullivan, R., Gilmartin, S., Uí Bhroin, S., Fitzpatrick, P., Patton, A., Jee Poh Hock, M., Graham, S., Kukaswadia, S., Prendergast, C., Ahmed, A., Dalla Vecchia, C., Lynch, J., Grummell, M., Grossi, I., MacManus, B., Turton, P., Battle, C., Samuel, K., Boyle, A., Waite, A., George, D., Johnston, B., Anandarajah, J., Vinagre, J., Roberts, Tom, Hirst, Robert, Sammut-Powell, Camilla, Reynard, Charles, Daniels, Jo, Horner, Daniel, Lyttle, Mark D., Samuel, Katie, Graham, Blair, Barrett, Michael J., Foley, James, Cronin, John, Umana, Etimbuk, Vinagre, Joao, and Carlton, Edward

Published
2021
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42. Dysfunctional Bronchial Cilia Are a Feature of Chronic Obstructive Pulmonary Disease (COPD)

Author

Thomas, Biju, primary, Koh, Mariko Siyue, additional, O’Callaghan, Christopher, additional, Allen, John Carson, additional, Rutman, Andrew, additional, Hirst, Robert Anthony, additional, Connolly, John, additional, Low, Su Ying, additional, Thun How, Ong, additional, Chian Min, Loo, additional, Lim, Wan Teck, additional, Lin Ean Oon, Lynette, additional, He, Qixian, additional, Teoh, Oon Hoe, additional, and Lapperre, Therese Sophie, additional

Published
2021
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43. Psychological distress and trauma during the COVID-19 pandemic: survey of doctors practising anaesthesia, intensive care medicine, and emergency medicine in the United Kingdom and Republic of Ireland

Author

Roberts, Tom, primary, Hirst, Robert, additional, Sammut-Powell, Camilla, additional, Reynard, Charles, additional, Daniels, Jo, additional, Horner, Daniel, additional, Lyttle, Mark D., additional, Samuel, Katie, additional, Graham, Blair, additional, Barrett, Michael J., additional, Foley, James, additional, Cronin, John, additional, Umana, Etimbuk, additional, Vinagre, Joao, additional, Carlton, Edward, additional, Kane, L., additional, Mackenzie, L., additional, Sharma Hajela, S., additional, Phizacklea, J., additional, Malik, K., additional, Mathai, N., additional, Sattout, A., additional, Messahel, S., additional, Fadden, E., additional, McQuillan, R., additional, O'Hare, B., additional, Lewis, S., additional, Bewick, D., additional, Taylor, R., additional, Hancock, I., additional, Manthalapo Ramesh Babu, D., additional, Hartshorn, S., additional, Williams, M., additional, Charlton, A., additional, Somerset, L., additional, Munday, C., additional, Turner, A., additional, Sainsbury, R., additional, Williams, E., additional, Patil, S., additional, Stewart, R., additional, Winstanley, M., additional, Tambe, N., additional, Magee, C., additional, Raffo, D., additional, Mawhinney, D., additional, Taylor, B., additional, Hussan, T., additional, Pells, G., additional, Barham, F., additional, Wood, F., additional, Szekeres, C., additional, Greenhalgh, R., additional, Marimuthu, S., additional, Macfarlane, R., additional, Alex, M., additional, Shrestha, B., additional, Stanley, L., additional, Gumley, J., additional, Thomas, K., additional, Anderson, M., additional, Weegenaar, C., additional, Lockwood, J., additional, Mohamed, T., additional, Ramraj, S., additional, Mackenzie, M., additional, Robertson, A., additional, Niven, W., additional, Patel, M., additional, Subramaniam, S., additional, Holmes, C., additional, Bongale, S., additional, Bait, U., additional, Nagendran, S., additional, Rao, S., additional, Mendes, F., additional, Singh, P., additional, Baron, T., additional, Ponmani, C., additional, Depante, M., additional, Sneep, R., additional, Brookes, A., additional, Williams, S., additional, Rainey, A., additional, Brown, J., additional, Marriage, N., additional, Manou, S., additional, Hart, S., additional, Elsheikh, M., additional, Cocker, L., additional, Elwan, M.H., additional, Vincent, K.L., additional, Nunn, C., additional, Sarja, N., additional, Viegas, M., additional, Wooffinden, E., additional, Reynard, C., additional, Cherian, N., additional, Da-Costa, A., additional, Duckitt, S., additional, Bailey, J., additional, How, L., additional, Hine, T., additional, Ihsan, F., additional, Abdullah, H., additional, Bader, K., additional, Pradhan, S., additional, Manoharan, M., additional, Kehler, L., additional, Muswell, R., additional, Bonsano, M., additional, Evans, J., additional, Christmas, E., additional, Knight, K., additional, O'Rourke, L., additional, Adeboye, K., additional, Iftikhar, K., additional, Evans, R., additional, Darke, R., additional, Freeman, R., additional, Grocholski, E., additional, Kaur, K., additional, Cooper, H., additional, Mohammad, M., additional, Harwood, L., additional, Lines, K., additional, Thomas, C., additional, Ranasinghe, D., additional, Hall, S., additional, Wright, J., additional, Ali, N., additional, Hunt, J., additional, Ahmad, H., additional, Ward, C., additional, Khan, M., additional, Holzman, K., additional, Ritchie, J., additional, Hormis, A., additional, Hannah, R., additional, Corfield, A., additional, Maney, J., additional, Metcalfe, D., additional, Timmis, S., additional, Williams, C., additional, Newport, R., additional, Bawden, D., additional, Tabner, A., additional, Malik, H., additional, Roe, C., additional, McConnell, D., additional, Taylor, F., additional, Ellis, R., additional, Morgan, S., additional, Barnicott, L., additional, Foster, S., additional, Browning, J., additional, McCrae, L., additional, Godden, E., additional, Saunders, A., additional, Lawrence-Ball, A., additional, House, R., additional, Muller, J., additional, Skene, I., additional, Lim, M., additional, Millar, H., additional, Rai, A., additional, Challen, K., additional, Currie, S., additional, Elkanzi, M., additional, Perry, T., additional, Kan, W., additional, Brown, L., additional, Cheema, M., additional, Clarey, A., additional, Gulati, A., additional, Webster, K., additional, Howson, A., additional, Doonan, R., additional, Trimble, A., additional, O’Connell, C., additional, Wright, R., additional, Colley, E., additional, Rimmer, C., additional, Pintus, S., additional, Jarman, H., additional, Worsnop, V., additional, Collins, S., additional, Colmar, M., additional, Masood, N., additional, McLatchie, R., additional, Peasley, A., additional, Rahman, S., additional, Mullen, N., additional, Armstrong, L., additional, Hay, A., additional, Mills, R., additional, Lowe, J., additional, Raybould, H., additional, Ali, A., additional, Cuthbert, P., additional, 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J., additional, and Vinagre, J., additional

Published
2021
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47. Psychological distress during the acceleration phase of the COVID-19 pandemic: a survey of doctors practising in emergency medicine, anaesthesia and intensive care medicine in the UK and Ireland

Author

Roberts, Tom, primary, Daniels, Jo, additional, Hulme, William, additional, Hirst, Robert, additional, Horner, Daniel, additional, Lyttle, Mark D, additional, Samuel, Katie, additional, Graham, Blair, additional, Reynard, Charlie, additional, Barrett, Michael, additional, Foley, James, additional, Cronin, John, additional, Umana, Etimbuk, additional, Vinagre, Joao, additional, and Carlton, Edward, additional

Published
2021
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48. Higher throughput drug screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

Author

Lee, Dani Do Hyang, primary, Cardinale, Daniela, additional, Nigro, Ersilia, additional, Butler, Colin R., additional, Rutman, Andrew, additional, Fassad, Mahmoud R., additional, Hirst, Robert A., additional, Moulding, Dale, additional, Agrotis, Alexander, additional, Forsythe, Elisabeth, additional, Peckham, Daniel, additional, Robson, Evie, additional, Smith, Claire M., additional, Somavarapu, Satyanarayana, additional, Beales, Philip L., additional, Hart, Stephen L., additional, Janes, Sam M., additional, Mitchison, Hannah M., additional, Ketteler, Robin, additional, Hynds, Robert E., additional, and O'Callaghan, Christopher, additional

Published
2021
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50. Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects

Author

Onoufriadis, Alexandros, Shoemark, Amelia, Schmidts, Miriam, Patel, Mitali, Jimenez, Gina, Liu, Hui, Thomas, Biju, Dixon, Mellisa, Hirst, Robert A., Rutman, Andrew, Burgoyne, Thomas, Williams, Christopher, Scully, Juliet, Bolard, Florence, Lafitte, Jean-Jacques, Beales, Philip L., Hogg, Claire, Yang, Pinfen, Chung, Eddie M.K., Emes, Richard D., OʼCallaghan, Christopher, Bouvagnet, Patrice, and Mitchison, Hannah M.

Published
2014
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