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Rayan Nikkilä,1– 4 Elli Hirvonen,1 Janne Pitkäniemi,1,5,6 Jari V Räsänen,7 Nea K Malila,1 Antti Mäkitie2,3,8 1Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; 2Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 3Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; 4Päijät-Häme Joint Authority for Health and Wellbeing, Department of Oral and Maxillofacial Surgery, Lahti Central Hospital, Lahti, 15850, Finland; 5Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; 6Department of Public Health, University of Helsinki, Helsinki, Finland; 7Department of General Thoracic and Oesophageal Surgery, Heart and Lung Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 8Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, SwedenCorrespondence: Antti Mäkitie, Helsinki University Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, P.O.Box 263, FI-00029 HUS, Helsinki, Finland, Tel +358-50-428 6847, Email antti.makitie@helsinki.fiPurpose: The occurrence of a second primary cancer (SPC) after primary esophageal carcinoma (EC) or gastric cardia carcinoma(GCC) is well acknowledged. However, previous research on the risk of SPC among these patients has been predominantly conducted in Asian countries. Yet, notable population-dependent variation in histological types and risk profiles exists. This register-based study assesses the histology-specific risk of SPC among individuals initially diagnosed with a first primary EC or GCC.Patients and Methods: We obtained data on 7197 patients diagnosed with EC/GCC in Finland between 1980 and 2022 from the Finnish Cancer Registry. Standardized incidence ratios (SIR) of SPC were subsequently calculated relatively to the cancer risk of the general population.Results: The average and median follow-up times were 2.8 years and 10.5 months. Adenocarcinomas and squamous cell carcinomas comprised 57.8% (n = 4165) and 36.6% (n = 2631) of all cases, respectively. An increased SIR was noted among EC/GCC patients after 15– 20 years of follow-up (SIR 1.49, 95% CI: 1.01– 2.11). Among adenocarcinoma patients, an increased SIR for SPCs of the digestive organs was seen in the 40– 54-year-old group (SIR 9.86, 95% CI: 3.62– 21.45). Squamous cell carcinoma patients displayed increased SIRs for cancer of the mouth/pharynx (SIR 3.20, 95% CI: 1.17– 6.95) and respiratory organs (1.77, 1.07– 2.76).Conclusion: Healthcare professionals should be aware of the increased risk of SPCs occurring in the mouth/pharynx, respiratory and digestive organs in survivors of EC/GCC. Patients should be advised about this risk and remain alert for symptoms, even beyond the standard 5-year follow-up period.Keywords: esophageal squamous cell carcinoma, adenocarcinoma, gastric cardia carcinoma, tumor, second primary cancer

The notion that modern buildings should strive to be net-zero energy buildings (NZEBs) is widely accepted. In order to improve window’s insulation in existing buildings, structured-core transparent vacuum insulation panels (TVIPs) are proposed. TVIPs mainly consist of the structured core material, the low-emissivity film, and the transparent gas barrier envelope. TVIPs have high insulation performance and are inexpensive to manufacture and can be easily installed. However, it is necessary to overcome the issue of preventing the pressure rise inside TVIP after vacuum sealing. The authors constructed an experimental setup by applying the pressure-rate-of-rise-method to establish the fabrication process for TVIPs that prevents the pressure rise. In this experiment, a gas barrier film with a straw was used as the vacuum chamber. This could reproduce the pressure increase in the TVIP after sealing and the gas flow rate in the TVIP is evaluated. The experimental results showed that the internal pressure of TVIP could be reduced to about 1 Pa after vacuuming while heating for 8 hours, coating the core material, and sealing the getter material.

The conversion of existing buildings to ZEH and ZEB requires increased thermal insulation, in which the insulation of window surfaces is particularly important. This study focused on measuring and comparing the changes in thermal conductivity of transparent vacuum insulation panels (TVIP), which could be used as simple and easy to install insulation to building windows. These changes were later compared with the results obtained from previous studies conducted by other research group members. The measured thermal conductivity values ranged between 0.017 W/(m*K) of the best performing frame-type with the thickness of 5.1 mm, and 0.011 W/(m*K) of the best performing double-layered peak-type core with the thickness of 7.8 mm. The calculated U-values of the samples ranged between 4.1 W/(m2*K) and 1.4 W/(m2*K). From the experimental results it could be seen that changing the core composition had a larger effect on the overall thermal conductivity of the sample than the added parameters of coating, getter agent, and heating had. These parameters, however, have had a substantial effect on the longevity of the vacuum inside the sample envelopes, and will thus be experimented further.