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1. ImmunoPET imaging of TIGIT in the glioma microenvironment

Author

Vincze, Sarah R., Jaswal, Ambika P., Frederico, Stephen C., Nisnboym, Michal, Li, Bo, Xiong, Zujian, Sever, ReidAnn E., Sneiderman, Chaim T., Rodgers, Mikayla, Day, Kathryn E., Latoche, Joseph D., Foley, Lesley M., Hitchens, T. Kevin, Frederick, Robin, Patel, Ravi B., Hadjipanayis, Costas G., Raphael, Itay, Nedrow, Jessie R., Edwards, W. Barry, and Kohanbash, Gary

Published
2024
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10. SPAK inhibitor ZT‐1a attenuates reactive astrogliosis and oligodendrocyte degeneration in a mouse model of vascular dementia

Author

Bhuiyan, Mohammad Iqbal H., primary, Habib, Khadija, additional, Sultan, Md Tipu, additional, Chen, Fenghua, additional, Jahan, Israt, additional, Weng, Zhongfang, additional, Rahman, Md Shamim, additional, Islam, Rabia, additional, Foley, Lesley M., additional, Hitchens, T. Kevin, additional, Deng, Xianming, additional, Canna, Scott W., additional, Sun, Dandan, additional, and Cao, Guodong, additional

Published
2024
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12. Amide proton transfer MRI at 9.4 T for differentiating tissue acidosis in a rodent model of ischemic stroke.

Author

Jin, Tao, Wang, Jicheng, Chung, Julius, Hitchens, T. Kevin, Sun, Dandan, Mettenburg, Joseph, and Wang, Ping

Subjects
ISCHEMIC stroke, LABORATORY rats, MAGNETIC resonance imaging, BRAIN damage, ACIDOSIS
Abstract

Purpose: Differentiating ischemic brain damage is critical for decision making in acute stroke treatment for better outcomes. We examined the sensitivity of amide proton transfer (APT) MRI, a pH‐weighted imaging technique, to achieve this differentiation. Methods: In a rat stroke model, the ischemic core, oligemia, and the infarct‐growth region (IGR) were identified by tracking the progression of the lesions. APT MRI signals were measured alongside ADC, T1, and T2 maps to evaluate their sensitivity in distinguishing ischemic tissues. Additionally, stroke under hyperglycemic conditions was studied. Results: The APT signal in the IGR decreased by about 10% shortly after stroke onset, and further decreased to 35% at 5 h, indicating a progression from mild to severe acidosis as the lesion evolved into infarction. Although ADC, T1, and T2 contrasts can only detect significant differences between the IGR and oligemia for a portion of the stroke duration, APT contrast consistently differentiates between them at all time points. However, the contrast to variation ratio at 1 h is only about 20% of the contrast to variation ratio between the core and normal tissues, indicating limited sensitivity. In the ischemic core, the APT signal decreases to about 45% and 33% of normal tissue level at 1 h for the normoglycemic and hyperglycemic groups, respectively, confirming more severe acidosis under hyperglycemia. Conclusion: The sensitivity of APT MRI is high in detecting severe acidosis of the ischemic core but is much lower in detecting mild acidosis, which may affect the accuracy of differentiation between the IGR and oligemia. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice

Author

Cai, Wei, Shi, Ligen, Zhao, Jingyan, Xu, Fei, Dufort, Connor, Ye, Qing, Yang, Tuo, Dai, Xuejiao, Lyu, Junxuan, Jin, Chenghao, Pu, Hongjian, Yu, Fang, Hassan, Sulaiman, Sun, Zeyu, Zhang, Wenting, Hitchens, T. Kevin, Shi, Yejie, Thomson, Angus W., Leak, Rehana K., Hu, Xiaoming, and Chen, Jun

Subjects
Stroke (Disease) -- Models -- Development and progression -- Care and treatment, CD8 lymphocytes -- Physiological aspects -- Health aspects, Health care industry
Abstract

Immunomodulation holds therapeutic promise against brain injuries, but leveraging this approach requires a precise understanding of mechanisms. We report that [CD8.sup.+][CD122.sup.+][CD49d.sup.lo] T regulatory-like cells ([CD8.sup.+] TRLs) are among the earliest lymphocytes to infiltrate mouse brains after ischemic stroke and temper inflammation; they also confer neuroprotection. TRL depletion worsened stroke outcomes, an effect reversed by [CD8.sup.+] TRL reconstitution. The CXCR3/CXCL10 axis served as the brain-homing mechanism for [CD8.sup.+] TRLs. Upon brain entry, [CD8.sup.+] TRLs were reprogrammed to upregulate leukemia inhibitory factor (LIF) receptor, epidermal growth factor-like transforming growth factor (ETGF), and interleukin 10 (IL-10). LIF/LIF receptor interactions induced ETGF and IL-10 production in [CD8.sup.+] TRLs. While IL-10 induction was important for the Anti-inflammatory effects of [CD8.sup.+] TRLs, ETGF provided direct neuroprotection. Poststroke intravenous transfer of [CD8.sup.+] TRLs reduced infarction, promoting long-term neurological recovery in young males or aged mice of both sexes. Thus, these unique [CD8.sup.+] TRLs serve as early responders to rally defenses against stroke, offering fresh perspectives for clinical translation., Introduction Immune responses play diverse roles in brain injury and repair after stroke. The sudden occlusion of a cerebral vessel leads to acute ischemic damage, followed by immediate activation of [...]

Published
2022
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18. Improved Subspace Estimation for Low-Rank Model-Based Accelerated Cardiac Imaging

Author

Christodoulou, Anthony G, Hitchens, T Kevin, Wu, Yijen L, Ho, Chien, and Liang, Zhi-Pei

Subjects
Information and Computing Sciences, Communications Engineering, Engineering, Computer Vision and Multimedia Computation, Biomedical Imaging, Cardiovascular, Heart Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Animals, Cardiac Imaging Techniques, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Mice, Models, Cardiovascular, Phantoms, Imaging, Rats, Reperfusion Injury, Cardiovascular magnetic resonance imaging, low-rank imaging, MRI pulse sequences, partial separability, subspace estimation, Artificial Intelligence and Image Processing, Biomedical Engineering, Electrical and Electronic Engineering, Biomedical engineering, Electronics, sensors and digital hardware, Computer vision and multimedia computation
Abstract

Sparse sampling methods have emerged as effective tools to accelerate cardiac magnetic resonance imaging (MRI).Low-rank model-based cardiac imaging uses a predetermined temporal subspace for image reconstruction from highly undersampled (k, t)-space data and has been demonstrated effective for high-speed cardiac MRI. The accuracy of the temporal subspace isa key factor in these methods, yet little work has been published on data acquisition strategies to improve subspace estimation. This paper investigates the use of non-Cartesian k-space trajectories to replace the Cartesian trajectories that are omnipresent but are highly sensitive to readout direction. We also propose "self-navigated" pulse sequences that collect both navigator data (for determining the temporal subspace) and imaging data after every RF pulse, allowing for even greater acceleration. We investigate subspace estimation strategies through analysis of phantom images and demonstrate in vivo cardiac imaging in rats and mice without the use of ECG or respiratory gating. The proposed methods achieved 3-D imaging of wall motion, first-pass myocardial perfusion, and late gadolinium enhancement in rats at 74 frames/s,as well as 2-D imaging of wall motion in mice at 97 frames/s.

Published
2014

19. Dual contrast CEST MRI for pH‐weighted imaging in stroke.

Author

Chung, Julius, Sun, Dandan, Hitchens, T. Kevin, Modo, Michel, Bandos, Andriy, Mettenburg, Joseph, Wang, Ping, and Jin, Tao

Subjects
STROKE, MAGNETIC resonance imaging, DIFFUSION magnetic resonance imaging, TISSUE viability, BRAIN injuries
Abstract

Purpose: pH enhanced (pHenh) CEST imaging combines the pH sensitivity from amide and guanidino signals, but the saturation parameters have not been optimized. We propose pHdual as a variant of pHenh that suppresses background signal variations, while enhancing pH sensitivity and potential for imaging ischemic brain injury of stroke. Methods: Simulation and in vivo rodent stroke experiments of pHenh MRI were performed with varied RF saturation powers for both amide and guanidino protons to optimize the contrast between lesion/normal tissues, while simultaneously minimizing signal variations across different types of normal tissues. In acute stroke, contrast and volume ratio measured by pHdual imaging were compared with an amide‐CEST approach, and perfusion and diffusion MRI. Results: Simulation experiments indicated that amide and guanidino CEST signals exhibit unique sensitivities across different pH ranges, with pHenh producing greater sensitivity over a broader pH regime. The pHenh data of rodent stroke brain demonstrated that the lesion/normal tissue contrast was maximized for an RF saturation power pair of 0.5 μT at 2.0 ppm and 1.0 μT at 3.6 ppm, whereas an optimal contrast‐to‐variation ratio (CVR) was obtained with a 0.7 μT saturation at 2.0 ppm and 0.8 μT at 3.6 ppm. In acute stroke, CVR optimized pHenh (i.e., pHdual) achieved a higher sensitivity than the three‐point amide‐CEST approach, and distinct patterns of lesion tissue compared to diffusion and perfusion MRI. Conclusion: pHdual MRI improves the sensitivity of pH‐weighted imaging and will be a valuable tool for assessing tissue viability in stroke. [ABSTRACT FROM AUTHOR]

Published
2024
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20. A novel needle mouse model of vascular cognitive impairment and dementia

Author

Weng, Zhongfang, primary, Cao, Catherine, additional, Stepicheva, Nadezda A., additional, Chen, Fenghua, additional, Foley, Lesley M., additional, Cao, Sarah, additional, Bhuiyan, Mohammad Iqbal H., additional, Wang, Qingde, additional, Wang, Yuan, additional, Hitchens, T Kevin, additional, Sun, Dandan, additional, and Cao, Guodong, additional

Published
2023
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21. Supplementary Figure 9 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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22. Supplementary Figure 8 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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23. FIGURE 4 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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24. Supplementary Figure 2 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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25. Supplementary Figure 3 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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26. FIGURE 2 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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27. FIGURE 3 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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28. Supplementary Figure 4 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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29. Data from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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30. FIGURE 5 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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31. Supplementary Figure 7 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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32. Supplementary Figure 1 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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33. FIGURE 1 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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34. Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., additional, Xiong, Zujian, additional, Sneiderman, Chaim T., additional, Raphael, Rebecca A., additional, Li, Bo, additional, Jaswal, Ambika P., additional, Sever, ReidAnn E., additional, Day, Kathryn E., additional, LaToche, Joseph D., additional, Foley, Lesley M., additional, Karimi, Hanieh, additional, Hitchens, T. Kevin, additional, Agnihotri, Sameer, additional, Hu, Baoli, additional, Rajasundaram, Dhivyaa, additional, Anderson, Carolyn J., additional, Blumenthal, Deborah T., additional, Pearce, Thomas M., additional, Uttam, Shikhar, additional, Nedrow, Jessie R., additional, Panigrahy, Ashok, additional, Pollack, Ian F., additional, Lieberman, Frank S., additional, Drappatz, Jan, additional, Raphael, Itay, additional, Edwards, Wilson B., additional, and Kohanbash, Gary, additional

Published
2023
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35. Supplementary Figure 6 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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36. Supplementary Figure 5 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma

Author

Nisnboym, Michal, primary, Vincze, Sarah R., primary, Xiong, Zujian, primary, Sneiderman, Chaim T., primary, Raphael, Rebecca A., primary, Li, Bo, primary, Jaswal, Ambika P., primary, Sever, ReidAnn E., primary, Day, Kathryn E., primary, LaToche, Joseph D., primary, Foley, Lesley M., primary, Karimi, Hanieh, primary, Hitchens, T. Kevin, primary, Agnihotri, Sameer, primary, Hu, Baoli, primary, Rajasundaram, Dhivyaa, primary, Anderson, Carolyn J., primary, Blumenthal, Deborah T., primary, Pearce, Thomas M., primary, Uttam, Shikhar, primary, Nedrow, Jessie R., primary, Panigrahy, Ashok, primary, Pollack, Ian F., primary, Lieberman, Frank S., primary, Drappatz, Jan, primary, Raphael, Itay, primary, Edwards, Wilson B., primary, and Kohanbash, Gary, primary

Published
2023
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38. High-Resolution Cardiovascular MRI by Integrating Parallel Imaging With Low-Rank and Sparse Modeling

Author

Christodoulou, Anthony G, Zhang, Haosen, Zhao, Bo, Hitchens, T Kevin, Ho, Chien, and Liang, Zhi-Pei

Subjects
Information and Computing Sciences, Engineering, Computer Vision and Multimedia Computation, Biomedical Engineering, Cardiovascular, Bioengineering, Heart Disease, Biomedical Imaging, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Algorithms, Animals, Heart, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Phantoms, Imaging, Rats, Cardiovascular MRI, group sparsity, inverse problems, low-rank modeling, partial separability, Artificial Intelligence and Image Processing, Electrical and Electronic Engineering, Biomedical engineering, Electronics, sensors and digital hardware, Computer vision and multimedia computation
Abstract

Magnetic resonance imaging (MRI) has long been recognized as a powerful tool for cardiovascular imaging because of its unique potential to measure blood flow, cardiac wall motion, and tissue properties jointly. However, many clinical applications of cardiac MRI have been limited by low imaging speed. In this paper, we present a novel method to accelerate cardiovascular MRI through the integration of parallel imaging, low-rank modeling, and sparse modeling. This method consists of a novel image model and specialized data acquisition. Of particular novelty is the proposed low-rank model component, which is specially adapted to the particular low-rank structure of cardiovascular signals. Simulations and in vivo experiments were performed to evaluate the method, as well as an analysis of the low-rank structure of a numerical cardiovascular phantom. Cardiac imaging experiments were carried out on both human and rat subjects without the use of ECG or respiratory gating and without breath holds. The proposed method reconstructed 2-D human cardiac images up to 22 fps and 1.0 mm × 1.0 mm spatial resolution and 3-D rat cardiac images at 67 fps and 0.65 mm × 0.65 mm × 0.31 mm spatial resolution. These capabilities will enhance the practical utility of cardiovascular MRI.

Published
2013

41. Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival following Immunotherapy in Murine GBM. (S17.009)

Author

Ziv, Michal Nisnboym, primary, Vincze, Sarah R., additional, Raphael, Itay, additional, Xiong, Zujian, additional, Sneiderman, Chaim T., additional, Raphael, Rebecca A., additional, Li, Bo, additional, Jaswal, Ambika P., additional, Sever, ReidAnn, additional, Day, Kathryn E., additional, LaToche, Joseph D., additional, Foley, Lesley M., additional, Hitchens, T. Kevin, additional, Agnihotri, Sameer, additional, Hu, Baoli, additional, Rajasundaram, Dhivyaa, additional, Anderson, Carolyn J., additional, Blumenthal, Deborah T., additional, Pearce, Thomas M., additional, Uttam, Shikhar, additional, Nedrow, Jessie R., additional, Panigrahy, Ashok, additional, Pollack, Ian F., additional, Lieberman, Frank S., additional, Drappatz, Jan, additional, Edwards, Wilson B., additional, and Kohanbash, Gary, additional

Published
2023
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44. Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

Author

Zhang, Jinwei, Bhuiyan, Mohammad Iqbal H., Zhang, Ting, Karimy, Jason K., Wu, Zhijuan, Fiesler, Victoria M., Zhang, Jingfang, Huang, Huachen, Hasan, Md Nabiul, Skrzypiec, Anna E., Mucha, Mariusz, Duran, Daniel, Huang, Wei, Pawlak, Robert, Foley, Lesley M., Hitchens, T. Kevin, Minnigh, Margaret B., Poloyac, Samuel M., Alper, Seth L., Molyneaux, Bradley J., Trevelyan, Andrew J., Kahle, Kristopher T., Sun, Dandan, and Deng, Xianming

Published
2020
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45. A Novel Needle Mouse Model of Vascular Cognitive Impairment and Dementia.

Author

Zhongfang Weng, Cao, Catherine, Stepicheva, Nadezda A., Fenghua Chen, Foley, Lesley M., Cao, Sarah, Bhuiyan, Mohammad Iqbal H., Qingde Wang, Yuan Wang, Hitchens, T. Kevin, Sun, Dandan, and Guodong Cao

Subjects
CEREBRAL circulation, MICE, COGNITION disorders, DEMENTIA, LABORATORY mice, ANIMAL disease models, BLOOD flow
Abstract

Bilateral common carotid artery (CCA) stenosis (BCAS) is a useful model to mimic vascular cognitive impairment and dementia (VCID). However, current BCAS models have the disadvantages of high cost and incompatibility with magnetic resonance imaging (MRI) scanning because of metal implantation. We have established a new low-cost VCID model that better mimics human VCID and is compatible with live-animal MRI. The right and the left CCAs were temporarily ligated to 32- and 34-gauge needles with three ligations, respectively. After needle removal, CCA blood flow, cerebral blood flow, white matter injury (WMI) and cognitive function were measured. In male mice, needle removal led to ∼49.8% and ∼28.2% blood flow recovery in the right and left CCA, respectively. This model caused persistent and long-term cerebral hypoperfusion in both hemispheres (more severe in the left hemisphere), and WMI and cognitive dysfunction in ∼90% of mice, which is more reliable compared with other models. Importantly, these pathologic changes and cognitive impairments lasted for up to 24 weeks after surgery. The survival rate over 24 weeks was 81.6%. Female mice showed similar cognitive dysfunction, but a higher survival rate (91.6%) and relatively milder white matter injury. A novel, low-cost VCID model compatible with live-animal MRI with long-term outcomes was established. [ABSTRACT FROM AUTHOR]

Published
2023
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48. TARGETED DEEP BRAIN STIMULATION OF THE MOTOR THALAMUS FACILITATES VOLUNTARY MOTOR CONTROL AFTER CORTICO-SPINAL TRACT LESIONS

Author

Ho, Jonathan C., primary, Grigsby, Erinn M., additional, Damiani, Arianna, additional, Liang, Lucy, additional, Balaguer, Josep-Maria, additional, Kallakuri, Sridula, additional, Barrios-Martinez, Jessica, additional, Karapetyan, Vahagn, additional, Fields, Daryl, additional, Gerszten, Peter C., additional, Hitchens, T. Kevin, additional, Constantine, Theodora, additional, Adams, Gregory M., additional, Crammond, Donald, additional, Capogrosso, Marco, additional, Gonzalez-Martinez, Jorge A., additional, and Pirondini, Elvira, additional

Published
2023
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49. Efficacy of novel SPAK inhibitor ZT-1a derivatives (1c, 1d, 1g & 1h) on improving post-stroke neurological outcome and brain lesion in mice

Author

Bhuiyan, Mohammad Iqbal H., primary, Fischer, Sydney, additional, Patel, Shivani M., additional, Oft, Helena, additional, Zhang, Ting, additional, Foley, Lesley M., additional, Zhang, Jinwei, additional, Hitchens, T. Kevin, additional, Molyneaux, Bradley J., additional, Deng, Xianming, additional, and Sun, Dandan, additional

Published
2023
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