Search

Your search keyword '"Hiwatashi, N."' showing total 267 results
Start Over Author "Hiwatashi, N."
267 results on '"Hiwatashi, N."'

4. Abstracts of selected papers presented at the 78th general meeting of the Japanese Society of Gastroenterology

Author

Kusano, Motoyasu, Sekiguchi, Toshikazu, Hanyu, Nobuyoshi, Aoki, Teruaki, Matsushima, Yasuhiro, Okamoto, Eizo, Takeda, Yasuo, Takeda, Ryoyu, Miyachi, Masahiko, Nimura, Yuji, Arai, Taidoh, Masuda, Jun, Tanaka, Masao, Ogawa, Yoshiaki, Ura, Kazuhide, Matsumoto, Teiji, Taniyama, K., Kurosawa, Susumu, Owyang, Chung, Baba, Hiroshi, Fujimura, Masaki, Hamada, Eiji, Shimada, Tadahito, Kabemura, Teppei, Chijiiwa, Yoshiharu, Sato, T., Koito, K., Matsuda, Hiroko, Kawasaki, Tsunehisa, Obara, Katsutoshi, Kasukawa, Reiji, Miyoshi, Hirofumi, Matsumoto, Akio, Yamamoto, Manabu, Ohmasa, Ryouji, Kokubu, Shigehiro, Shibata, Hisao, Tajiri, Takashi, Onda, Masahiko, Hashizume, Makoto, Sugimachi, Keizo, Kobayashi, Kenji, Shiozaki, Hitoshi, Fujisaki, Junko, Shimoda, Tadakazu, Hase, Satoshi, Tsukamoto, Yoshihisa, Atsumi, M., Konishi, H., Nakajo, Shinobu, Fujiyama, Yoshihide, Taruishi, Masaki, Ayabe, Tokiyoshi, Morise, Kimitomo, Yamaguchi, Takeo, Makiyama, Kazuya, Itsuno, Minoru, Matsui, T., Okabe, N., Okabe, Nobuo, Matsui, Toshiyuki, Sakatani, Arata, Koizumi, Koichi, Imai, Yutaka, Sugino, Yoshinori, Masaki, Tadahiko, Sawada, Toshio, Nishigami, Takashi, Satomi, Masamichi, Hatada, Yasumasa, Saito, Hiroshi, Kobayshi, Kiyonori, Katsumata, Tomoe, Sugimoto, Kenji, Itabashi, Tsukasa, Kitagawa, Motoji, Hayakawa, Tetsuo, Okazaki, Kazuichi, Yamamoto, Yasuro, Funakoshi, Akihiro, Miyasaka, Kyoko, Soejima, Kazuhiko, Kanda, Mikio, Sugiyama, Masanori, Kuroda, Akira, Inoue, Hisayuki, Bamba, Tadao, Hamanaka, Y., Suzuki, T., Suzuki, Mamoru, Hanyu, Fujio, Tamura, Katsuhiro, Nakase, Akira, Noguchi, M., Hiwatashi, N., Murata, Yuhji, Suzuki, Kazuo, Ohtani, Haruo, Watanabe, Yoshihisa, Zeniya, Mikio, Aizawa, Yoshio, Masumoto, T., Onji, M., Hamasaki, Keisuke, Nakata, Keisuke, Fukui, Hiroshi, Tsujii, Tadasu, Yamashiki, Masayoshi, Nishimura, Akira, Tsutsui, Hiroko, Mizoguchi, Yasuhiro, Kimura, Fumio, Miyazaki, Masaru, Kiyota, Keisuke, Inokuchi, Hideto, Yamamoto, Yoshihiro, Oka, Hiroshi, Horikoshi, Tsutomu, Sekiguchi, Toshikazu, Takayasu, H., Shirai, T., Hongo, Michio, Okuno, Yo, Okano, H., Aoyama, N., Ohsuki, Masao, Maeda, Kenji, Haruma, Ken, Sumii, Koji, Nakai, Yoshihide, Fukunaga, Mikihiko, Kaneko, Hiroshi, Morise, Kimitomo, Okumura, Toshikatsu, Uehara, Akira, Fukuda, Yoshihiro, Satomi, Masamichi, Joh, Takashi, Itoh, Makoto, Kitagawa, Yuko, Kitajima, Masaki, Iwao, Tadashi, Toyonaga, Atsushi, Nakamura, Masahiko, Oda, Masaya, Kawamura, Yukimitsu, Dohden, Kenji, Kamiyama, Yasuhiko, Matsuno, Seiki, Hirano, Morihisa, Otsuka, Sachio, Ito, Masahiro, Sekine, Ichiro, Ogihara, Tatsuo, Sato, Nobuhiro, Uehara, Akira, Namiki, Masayoshi, Sugiura, Nobuyuki, Ebara, Masaaki, Matsuo, Naoki, Uchida, Hideo, Okada, Shuichi, Okazaki, Nobuo, Tsujii, Hirohiko, Ohsuga, Toshiaki, Abe, M., Nagata, Y., Yamasaki, Susumu, Kosuge, Tomoo, Kitamoto, Mikiya, Nakanishi, Toshio, Ichikawa, Yuzo, Mizoguchi, Yasuhiro, Ohtake, Yoshio, Hirasawa, Hiroyuki, Sugihara, Junichi, Muto, Yasutoshi, Yasunaga, Mitsuru, Okita, Kiwamu, Ukida, Minoru, Tsuji, Takao, Isai, Hideya, Uchino, Junichi, Suzuki, Katsuhiko, Komatsu, Kanji, Ohtomo, Yumiko, Idezuki, Yasuo, Sakuramachi, Shunji, Kimura, Taizo, Kitano, Seigo, Sugimachi, Keizo, Moriyama, Masaaki, Yazaki, Yasuyuki, and Saito, Takashige

Published
1993
Full Text
View/download PDF

5. Abstracts of selected papers presented at the 77th General Meeting of the Japanese Society of Gastroenterology: March 28–30, 1991, Tokyo, Japan

Author

Kijima, Hiroshi, Watanabe, Hidenobu, Tomatsu, Sei, Oi, Itaru, Nagaiwa, Jiro, Ariyama, Jo, Mitake, Masahiro, Naitoh, Yasuo, Ono, Yoshiki, Yokomizo, Seiji, Nakayama, Toshimichi, Sugimura, Fumiaki, Matsuo, Yutaka, Murayama, Isao, Tanaka, Takashi, Hanyu, Nobuyoshi, Aoki, Teruaki, Shiraha, Sei, Shiraha, Sei, Hiura, Akihito, Satake, Katsusuke, Suda, Koichi, Sakamoto, Yoshiya, Okazaki, Kazuichi, Kondo, Takaharu, Hayakawa, Tetsuo, Kanoh, Makoto, Kohashi, Etsu, Kataoka, Keisho, Kashima, Kei, Yokotani, Kunihiko, Yamada, Tadataka, Mieno, Hiroshi, Shirakawa, Toshio, Komatsu, Hirokazu, Oda, Masaya, Nakamura, Keiya, Aoike, Akira, Takagi, Yoji, Inoue, Yoshifumi, Kasahara, Hiroshi, Saitoh, Yoichi, Tashiro, T., Mashima, Y., Sasaki, Fumiaki, Uchino, Junichi, Haraguchi, Yoshikura, Kirita, Manabu, Iwasa, Masato, Ogoshi, Shohei, Sato, Nobuaki, Matsubara, Youichi, Kinouchi, Y., Hiwatashi, N., Chikamochi, Nobuo, Nakajo, Shinobu, Yoshida, Takashi, Muto, Yasutoshi, Suzuki, Kazutomo, Arakawa, Yasuyuki, Takahashi, Hiroaki, Noguchi, Takashi, Suzuki, Hiroshi, Okabe, Kazuhiko, Azuma, Megumu, Koizumi, Masaru, Kawaguchi, Shinya, Matsuno, Seiki, Tsuji, Shingo, Kawano, Sunao, Oda, Masaya, Nakamura, Masahiko, Nakamura, Hajime, Kobayashi, Kenzo, Kashiwagi, Hideyuki, Aoki, Teruaki, Nishikawa, Masahiro, and Suzuki, Takashi

Published
1992
Full Text
View/download PDF

14. Proceedings of the international session of the 26th annual meeting October 18–20, 1984—Chiba, Japan

Author

Kato, Y., Miyamori, H., Unoura, M., Ohmizo, N., Tanaka, N., Kobayashi, K., Hattori, N., Arakawa, Y., Amaki, S., Shikata, T., Liu, Bang-Hyun, Kanai, K., Morioka, S., Nishida, M., Noto, H., Takahashi, K., Matsushita, K., Beasley, R. Palmer, Hwang, Lu-Yu, Yano, M., Shima, M., Tsunoda, E., Koga, M., Minamino, T., Tsuji, T., Kagawa, K., Okuno, T., Takino, T., Kurihara, Takeshi, Obata, Hiroshi, Beasley, R. Palmer, Okita, K., Konishi, T., Kado, Y., Yokosuka, O., Omata, M., Imazeki, F., Ryuu, M., Okuda, K., Mitamura, Keiji, Chen, D. S., Sung, J. L., Lai, M. Y., Sheu, J. C., Hsu, H. C., Nakamura, T., Morizane, T., Tsuchiya, M., Kobayashi, K., Unoura, M., Okawa, K., Kobayashi, K., Kitano, A., Kuwajima, S., Hashimura, H., Matsumoto, T., Hiki, M., Yamamoto, S., Kinoshita, Y., Nagura, H., Shioda, Y., Tsutsumi, Y., Hasegawa, H., Watanabe, K., Kanoh, T., Nishida, O., Uchino, H., Miyake, T., Hishitani, Y., Bhargava, D. K., Shriniwas, B. N. Tandon, Kapur, B. M. L., Chawla, T. C., Kiran, Usha, Gupta, J. P., Jain, A. K., Agrawal, B. K., Gupta, Saroj, Chiba, M., Sasaki, M., Konn, M., Yamanaka, Y., Morita, T., Hashizume, T., Nara, K., Odagiri, H., Fujii, M., Ono, K., Nio, Y., Tsuchitani, T., Inamoto, T., Kodama, H., Tobe, T., Shi, Z. R., Kim, Y. S., Yamaoka, H., Nishiyama, K., Tajima, S., Fukushima, T., Tsuchiya, S., Kuroe, K., Kimura, A., Suwa, Y., Furukawa, H., Miyake, T., Watanabe, M., Yoshida, T., Aiso, S., Asakura, H., Tsuchiya, M., Miura, M., Hiwatashi, N., Fujiyama, Y., Kobayashi, K., Bamba, T., Hosoda, S., Benno, Y., Wakashin, Y., Wakashin, M., Mori, T., Ueda, S., Yoshida, H., Mori, Y., Okuda, K., You, Li, Wei-Fa, Ye, Yang, Guang-Xao, Ye, Wei-Fa, Nelwan, R. H. H., Gandhi, B. M., Gupta, H., Irshad, M., Chawla, T. C., Tandon, B. N., Cho, Mong, Liu, Bang-Hyun, Wu, Xie-ning, Tandon, Rakesh K., Srivastava, A. K., Kapur, B. M. L., Misra, R. K., Jiang, Shi-hu, Lin, Yan-zun, Liu, Bang-Hyun, Abdurachman, S. A., Hadi, Sujono, Bhargava, D. K., Agrawal, B. K., Bhat, K. R., Baoen, Wang, Madanagopalan, N., Solomon, V., Jayanthi, V., Raghuram, K., Kandasamy, I., Annapoorani, S., Gajarai, A., Panchanadam, M., Joshi, Y. K., Gandhi, B. M., Tandon, B. N., Hassan, A., Guntur, H., Soemarto, R., Rahardja, S. H., Soemarto, W., Baoen, Wang, Park, Keun-Soo, Liu, Bang-Hyun, Yao, G. B., Zhang, L. M., Wu, M. F., Tong, S. T., Tian, Y. F., Iwai, N., Kaneda, H., Tsuto, T., Yanagihara, J., Takahashi, T., Jinkun, Zhang, Jinkun, Zhang, Durrani, Hamid A., Gupta, J. P., Jain, A. K., Govil, A. K., Tripathi, V. N. P., Baoen, Wang, Shi, Z. R., Yin, D. Y., Wen, F. Q., Zhang, Jinkun, Panchanadam, M., Balasubramania, V. C., Are, P. S., Thyagarajan, S. P., Mahadevan, S., Dravidamani, S., Nigam, Pranesh, Agrawal, A. K., Kapoor, K. K., Lesmana, L., Sidharta, H., Marwoto, W., Akbar, N., Sulaiman, A., Sjaifoellah Noer, H. M., Gupta, J. P., Tantry, B. V., Jain, A. K., Sheu, J. C., Chen, D. S., Sung, J. L., Chuang, C. N., Yang, P. M., Lin, J. T., Hsu, H. C., Sheu, J. C., Lin, Y. H., Chen, D. S., Lee, C. S., Beasley, R. P., Hwang, L. Y., Nigam, Pranesh, Kapoor, K. K., and Gupta, A. K.

Published
1985
Full Text
View/download PDF

15. Peripheral granulocytes of patients with Crohn's disease express increased numbers of functional IgG Fc receptor I

Author

Kayaba Y, Hiwatashi N, Ryoichi Nagatomi, Toyota T, and Majima T

Subjects
Adult, Male, Adolescent, Neutrophils, Prednisolone, Receptors, IgG, Antibodies, Monoclonal, Flow Cytometry, Neutrophil Activation, Immunoenzyme Techniques, Aminosalicylic Acids, Crohn Disease, Superoxides, Luminescent Measurements, Humans, Female, Intestinal Mucosa, Mesalamine
Abstract

Activated phagocytes are involved in the pathogenesis of Crohn's disease (CD). To clarify the activation of polymorphonuclear leukocytes (PMN) from CD patients in relationship with the clinical status, we investigated not only the expression of Fc receptor for IgG (huFc gamma R) but also the ability of the PMN to produce free oxygen radicals on stimulation of these receptors by using chemiluminescent techniques. The PMN obtained from the patients with active disease showed an enhanced chemiluminescence (CL) in response to huFc gamma RI stimulation, and an increased expression of huFc gamma RI. Moreover, PMN with huFc gamma RI were recognized in the colonic inflammatory lesions. After a successful treatment, however, we could hardly detect both the CL production and the expression of huFc gamma RI. Thus, it is suggested that the measurement of CL production through huFc gamma RI and the evaluation of the expression of huFc gamma RI are useful to evaluate the clinical status of the CD patients in a more accurate manner. The involvement of huFc gamma RI positive PMN in tissue destruction has been discussed.

Published
1993

20. A Case of Pregnancy and Delivery Managed by Ileostomy for Rectovaginal Fistula Associated with Crohn's Disease.

Author

Ueno, T., primary, Sasaki, I., additional, Naitoh, H., additional, Funayama, Y., additional, Fukushima, K., additional, Shibata, C., additional, Ohtani, N., additional, Koyama, K., additional, Masuko, T., additional, Takahashi, K., additional, Ogawa, H., additional, Satoh, S., additional, Hashimoto, A., additional, Kitayama, T., additional, Matsuno, S., additional, and Hiwatashi, N., additional

Published
1999
Full Text
View/download PDF

38. Development of consensus statements for the diagnosis and management of intestinal Behçet's disease using a modified Delphi approach.

Author

Kobayashi K, Ueno F, Bito S, Iwao Y, Fukushima T, Hiwatashi N, Igarashi M, Iizuka B, Matsuda T, Matsui T, Matsumoto T, Sugita A, Takeno M, Hibi T, Kobayashi, Kenji, Ueno, Fumiaki, Bito, Seiji, Iwao, Yasushi, Fukushima, Tsuneo, and Hiwatashi, Nobuo

Abstract

Background: Although intestinal Behçet's disease has been treated anecdotally with various therapeutic modalities, clinical evidence regarding management of intestinal Behçet's disease is lacking. The objective of this study was to develop consensus-based practice guidelines for diagnosis and treatment of intestinal Behçet's disease by using a modified Delphi approach.Methods: Three groups of Japanese gastroenterology specialists were involved in the study: moderators, an expert panel, and a professional group. Clinical statements for ratings were extracted from relevant literature, a survey of the professional group, and by discussion among the expert panel. The expert panel rated the clinical statements according to a nine point scale. After the first round of ratings, a panelist meeting was held to discuss areas of disagreement and to clarify areas of uncertainty. The list of clinical statements was revised after the panelist meeting, and a second round of rating was conducted.Results: Thirty-two relevant articles were selected in a literature search, and 35 clinical statements were extracted. An additional 209 clinical statements were developed from the survey and discussion among gastroenterology specialists. In the first and second rounds, 56% and 60% of statements, respectively, received median scores > or =7. The range of scores decreased considerably from the first to the second round.Conclusions: 5-Aminosalycylic acid, corticosteroids, immunosuppressants, enteral nutrition, total parenteral nutrition, and surgical therapy were considered standard therapy for intestinal Behçet's disease. Infliximab, colchicines, thalidomide, other pharmacological therapy, endoscopic therapy, and leukocytapheresis were deemed experimental therapy. Based on a two-round modified Delphi approach, practice guidelines for diagnosis and treatment of intestinal Behçet's disease were developed. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

40. Clinical course and longterm prognosis of Japanese patients with Crohn's disease: predictive factors, rates of operation, and mortality.

Author

Oriuchi T, Hiwatashi N, Kinouchi Y, Takahashi S, Takagi S, Negoro K, and Shimosegawa T

Abstract

BACKGROUND: The purpose of this study was to clarify the long-term course of Crohn's disease (CD) and predictors of its prognosis in Japan. METHODS: This was a historical cohort study of 276 patients with CD who had been diagnosed between 1965 and 1998. The clinical course was evaluated by the course of the CD score (CCDS) according to the required treatments. The predictive factors were examined by stepwise regression test. The cumulative rates of operation and survival were calculated by the Kaplan-Meier method. RESULTS: Patients with colitis-type CD had significantly lower annual and cumulative operation rates than those with other types, and showed significantly better progress, estimated by the CCDS, than patients with ileocolitis type. Reliable predictors for the 2- to 5-year clinical course after starting treatment were the CCDS, the presence of laparotomy during the initial year, and onset at age 30 years or more. The predictors for the 6- to 10-year clinical course were the duration of symptoms at diagnosis and onset at age 16 years or less. The predictors for the 11- to 15-year clinical course were the CCDS, the maximum International Organization of the Study of Inflammatory Bowel Disease (IOIBD) assessment score during the first year after starting treatment, and the effectiveness of the initial treatment. Relative survival rates at 5, 10, 15, and 20 years after the onset were 98.9%, 98.1%, 97.7%, and 94.9%, respectively. CONCLUSIONS: CD patients with colitis type showed a better clinical course and had significantly different clinical features compared with the patients with ileitis and ileocolitis type. Prediction of the longterm course of CD is possible by using clinical factors during the first year after starting treatment. The relative survival rates in Japanese patients with CD are not different from those seen in Western countries. The purpose of this study was to clarify the long-term course of Crohn's disease (CD) and predictors of its prognosis in Japan. [ABSTRACT FROM AUTHOR]

Published
2003
Full Text
View/download PDF

43. Telomere shortening in the colonic mucosa of patients with ulcerative colitis.

Author

Kinouchi, Yoshitaka, Hiwatashi, Nobuo, Chida, Masaki, Nagashima, Fumio, Takagi, Sho, Maekawa, Hiroki, Toyota, Takayoshi, Kinouchi, Y, Hiwatashi, N, Chida, M, Nagashima, F, Takagi, S, Maekawa, H, and Toyota, T

Subjects
TELOMERES, ULCERATIVE colitis, DYSPLASIA, ANEUPLOIDY
Abstract

Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Mucosal cells of the affected colon show rapid turnover in individuals with active ulcerative colitis (UC). Telomere length was determined by Southern blot analysis of terminal restriction fragments (TRFs) from the colonic mucosa of 17 patients with UC in remission, two of whom showed dysplasia, and 17 control subjects without colitis. For each individual, mean TRF length was compared between rectal mucosa and unaffected cecal mucosa. The mean TRF length of the rectal mucosa was significantly less than that of cecal mucosa in UC patients (7.87 +/- 0.36kb versus 8.77 +/- 0.21 kb; P = 0.0015, Wilcoxon signed rank test), whereas no significant difference was detected in the control subjects. The extent of telomere shortening was 10.6 +/- 3.35% in UC patients, compared with 0.8 +/- 0.64% in noncolitis controls (P = 0.0024, Mann-Whitney U-test). Four UC patients, two of whom had dysplasia, showed telomere shortening of more than 20% in the rectal mucosa. These observations suggest that telomere shortening in the colonic mucosa of individuals with UC may represent the history of mucosal inflammation during disease of long duration, and that it may contribute to aneuploidy in UC. [ABSTRACT FROM AUTHOR]

Published
1998
Full Text
View/download PDF

44. Crohn's disease is associated with novel polymorphisms in the 5'-flanking region of the tumor necrosis factor gene

Author

Negoro, K., Kinouchi, Y., Hiwatashi, N., Takahashi, S., Takagi, S., Satoh, J., Shimosegawa, T., and Toyota, T.

Abstract

Background & Aims: Tumor necrosis factor (TNF) is considered to play an important role in the pathogenesis of Crohn's disease (CD). Recently, 3 polymorphisms in the 5'-flanking region of the TNF gene at positions -1031, -863, and -857, which are related to high transcriptional promoter activity, have been identified in the Japanese population. In an effort to understand potential genetic association with CD, we evaluated patients diagnosed with CD and ulcerative colitis (UC) in the presence of other novel polymorphisms. Methods: Blood samples were obtained from 103 patients with CD and 76 patients with UC. Polymorphisms in the TNF gene at their respective positions were analyzed by direct sequencing, and the allele frequencies were compared with those determined previously in a healthy Japanese population. Results: Allele frequencies of -1031C, -863A, and -857T in normal controls were 16.0%, 14.0%, and 17.7%, respectively. Polymorphic allele frequencies at positions -1031, -863, and -857 were 24.3%, 21.8%, and 27.2% in CD and 11.8%, 11.2%, and 11.8% in UC, respectively. The frequencies at all 3 positions were significantly higher in CD patients than in UC patients or healthy controls. Among the subgroups of CD, small bowel disease showed the highest frequencies. Conclusions: Although the findings need to be confirmed in other populations with larger numbers of patients, TNF gene polymorphisms -1031C, -863A, and -857T are positively associated with CD; they may influence not only the susceptibility to CD but also the disease location. GASTROENTEROLOGY 1999;117:1062-1068

Published
1999
Full Text
View/download PDF

45. Altered Leukotriene B4 Metabolism in Colonic Mucosa with Inflammatory Bowel Disease

Author

Ikehata, A., Hiwatashi, N., Kinouchi, Y., Yamazaki, H., Ito, K., and Toyota, T.

Abstract

Background: ω-Oxidation is regarded as the major pathway for leukotriene B4 (LTB4) metabolism. Very little is known about it in colonic mucosa with inflammatory bowel disease (IBD). Methods: We investigated the metabolic ratio of ω-oxidation to LTB4 biosynthesis in colonic mucosa from patients with IBD and control subjects. After incubation of colonic mucosa with 14C-arachidonic acid and ionophore A23187, we separated LTB4 and its ω-oxidative metabolites by high-performance liquid chromatography. Results: The rate of LTB4 ω-oxidation was comparable to the rate of its biosynthesis. The metabolic ratio was significantly decreased in inflamed mucosa with ulcerative colitis. Conclusions: LTB4 ω-hydroxylase activity is an important factor in regulating LTB4 level in colonic mucosa, and the increased LTB4 level in inflamed mucosa with IBD, especially ulcerative colitis, is caused by decreased LTB4 ω-hydroxylase activity and increased 5-lipoxygenase activity.

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results